Session I: Stem cells, senescence and regeneration
Chair: David Vilchez
14.00 – 14.15 Welcome Björn Schumacher
14.15 – 14.20 Introduction to session David Vilchez
14.20 – 14.50 Aziz Aboobaker University of Oxford, Department of Zoology,
Oxford, UK
"The molecular and cellular basis of stem cell underpinning
of an immortal life history"
14.50 – 15.20 Jan van Deursen Mayo Clinic, Rochester, MN, US
“How senescent cells drive aging and disease”
15.20 – 15.32 Marco Demaria ERIBA, Groningen, NL
"Cellular senescence promotes adverse reactions to chemotherapy“
15.32 – 15.44 Laura Greaves Newcastle University,Newcastle, UK
„Age-associated mitochondrial dysfunction promotes intestinal
tumor development“
15.44 – 15.56 Lida Katsimpardi, Harvard University, Cambridge, MA, US;
Institut Pasteur, Paris, France
"Young blood as a therapy for age-related neurodegenerative
diseases“
15.56 – 16.30 Coffee break
Chair: Elena Rugarli
16.30 – 17.00 Joan Mannick Novartis Institutes for BioMedical Research, Cambridge,
MA, US
„mTOR inhibition improves immune function in elderly humans“
17.00 – 17.30 Thomas A. Rando Stanford Dep. of Neurology, Stanford University,
Stanford, CA, US
„Epigenetic mechanisms of stem cell aging and rejuvenation“
17.30 – 17.42 Olena Kucheryavenko Institute for Ageing and Institute for Cell and
Molecular Biosciences, Newcastle, UK
„Interventions to limit senescence-induced bystander effect“
17.42 – 17.54 Helen Tauc Institut für Biochemie & Molekulare Biologie,
Universität Ulm, DE
"Nipped-A/TRRAP maintains midgut homeostasis during aging in
Drosophila by regulating intestinal stem cell proliferation“
17.54 – 18.06 Yosef Reut Weizmann Institute of Science, Rehovot, IL
„Directed elimination of senescent cells by inhibition of BCL-W
and BCL-XL“
18.06 – 21.00 Poster session I / Kölsch, Snacks
Session II: Protein homeostasis and proteotoxic diseases
Chair: Thorsten Hoppe
09.00 – 09.05 Introduction to session Thorsten Hoppe
09.05 – 09.35 Anne Bertolotti MRC Laboratory of Molecular Biology, Cambridge,
Biomedical Campus Cambridge, UK
“Preventing protein quality control failure and neurodegenerative
diseases“
09.35 – 10.05 Monique Breteler German Center for Neurodegenerative diseases
(DZNE), Bonn, DE; Harvard T.H. Chan School of Public Health
Department of Epidemiology, Boston, MA, US
"Common mechanisms and disease-specific pathways in age-related
diseases"
10.05 – 10.17 Jonathan Byrne Institute of Molecular Biology (IMB), Mainz, DE
„Antagonistic Pleiotropy in the autophagic machinery modulates
lifespan conversely over age in C. elegans“
10.17 – 10.29 Ilias Gkikas Institute of Molecular Biology and Biotechnology,
Heraklion, GR
„An alternative hypoxia response mechanism independent of
HIF-1 involves mitochondrial metabolic adaptation“
10.29 – 10.41 Michael Lammers CECAD, Cologne, DE
“Lysine-acetylation in cellular regulation, ageing and disease“
10.41 – 11.10 Coffee break
Chair: Adam Antebi
11.10 – 11.40 Ivan Dikic IBC II, Goethe University, Frankfurt, DE
“Ubiquitin networks in regulation of proteostasis and autophagy”
11.40 – 12.10 Stefan Jentsch Max Planck Institute of Biochemistry, Dept. of
Molecular Cell Biology, Martinsried, DE
“Splicing fidelity controlled by the ubiquitin relative hub1“
12.10 – 12.22 Marie Lechler DZNE, Tübingen, DE
„Investigating stress granule insolubility with age“
12.22 – 12.34 Hyun Kate Lee Max Planck Institute of Molecular Cell Biology
and Genetics, Dresden, DE
„Age-dependent aberrant transition of membraneless organelles
into pathological aggregates“
12.34 – 12.46 Michal SchweigerUniversity Hospital of Cologne, Functional
Epigenomics, CCG, Cologne, DE
„Splicing during heat shock is regulated by the bromodomain
protein BRD4 and the heat shock transcription factor 1“
12.46 – 14.50 Poster session II, Lunch
Session III: Nuclear Organization and Genome Stability
Chair: Björn Schumacher
14.50 – 14.55 Introduction to session Björn Schumacher
14.55 – 15.25 Eric Gilson IRCAN, Nice, FR
"The double life of telomeric proteins“
15.25 – 15.55 Jacqueline Jacobs NKI, Amsterdam, NL
“Mechanisms underlying genome instability upon DNA
repair at telomeres“
15.55 – 16.07 Niels de Wind 1Dep. of Human Genetics, Leiden University
Medical Center, Leiden, NL
“Endogenous DNA damage, replication stress, and ageing”
16.07 – 16.19 Nard Kubben National Cancer Insitute (NCI), Bethesda, MD, US
„Repression of the antioxidant NRF2 pathway in premature aging“
16.19 – 16.50 Coffee break
Chair: Nils-Göran Larsson
16.50 – 17.20 Andrei Seluanov University of Rochester, Department of Biology,
Rochester, NY, US
“SIRT6 is the new guardian of the genome“
17.20 – 17.50 Manuel Serrano Centro Nacional de Investigaciones Oncológicas,
Madrid, ES
“Tissue repair: an integrated view of senescence and
reprogramming“
17.50 – 18.02 Argyris Papantonis CMMC, Cologne, DE
“Common determinants of global 3D chromatin
reorganization upon senescence of different primary human
cells: a link to the SASP”
18.02 – 18.14 Lene Rasmussen Center for Healthy Aging, Copenhagen, DK
„Rev1-deficiency induces age-related disorders via PARP1
activation and impaired mitochondrial homeostasis“
18.14 – 18.26 Gisela Slaats CECAD, Cologne, DE
“DNA replication sress underlies renal phenotypes in
CEP290-associated joubert syndrome”
19.00 Dinner (only invited guests)
Session IV: Metabolism
Chair: Jens Brüning
09.00 – 09.05 Introduction to session Jens Brüning
09.05 – 09.35 Michael Hall Biozentrum University of Basel, Basel, CH
“mTOR signaling in growth and metabolism“
09.35 – 10.05 Brian Luke Institute for Molecular Biology, Mainz, DE
“The regulation of TORC1 activity has important influences
on the DNA damage checkpoint response“
10.05 – 10.17 Cornelis Calkhoven ERIBA, Groningen, NL
"mTORC1-C/EBPβ regulation of healthspan and lifespan”
10.17 – 10.29 Alessandro CellerinoScuola Normale Superiore,
BIO@SNS, Pisa, IT
„MicroRNA-29 controls a compensatory response to limit
neuronal iron accumulation during aging“
10.29 – 10.41 Collin Ewald ETH Zürich, Zürich, CH
“Reduced insulin/IGF-1-signalling implicates extracellular
matrix remodelling in longevity”
10.41 – 11.10 Coffee break
Chair: Linda Partridge
11.10 – 11.40 David Sabatini Whitehead Institute for Biomedical Research,
MIT, Bosten, MA, US
“Control of growth and metabolism by mTOR“
11.40 – 12.10 Aurelio Teleman DKFZ Heidelberg, DE
“Physiological regulation by stearic acid”
12.10 – 12.40 Marian Walhout University of Massachusetts, MA, US
“Nutritional regulatory networks“
12.40 – 12.52 Dario Valenzano MPI Biology of Ageing, Cologne, DE
“Changes in the intestinal microbiota affect ageing in the
short-lived African turquoise killifish”
12.52 – 13.15 Poster prize
13.15 – 14.00 Lunch