Publications 2016

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Adam Antebi

  • Greer EL, Becker B, Antebi A, Shi Y (2016). Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. Cell Res. 26(2): 229-38
  • Johnsen M, Späth MR, Denzel MS, Göbel H, Kubacki T, Hoyer KJ, Hinze Y, Benzing T, Schermer B, Antebi A, Burst V, Müller RU (2106). Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage. PLoS One. 24;11(8):e0161315
  • Nakamura S, Karalay Ö, Jäger PS, Horikawa M, Klein C, Nakamura K, Latza C, Templer SE, Dieterich C, Antebi A (2016). Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. Nat Commun. 7:10944
  • Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE (2016). Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell. doi: 10.1111/acel.12496        
  • Wang D, Hou L, Nakamura S, Su M, Li F, Chen W, Yan Y, Green CD, Chen D, Zhang H, Antebi A, Han JJ (2016). LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis. Aging Cell. doi: 10.1111/acel.12539

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Thomas Benzing

  • Bartram MP, Habbig S, Pahmeyer C, Hohne M, Weber LT, Thiele H, Altmuller J, Kottoor N, Wenzel A, Krueger M, Schermer B, Benzing T, Rinschen MM, Beck BB (2016). Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS. Hum Mol Genet. 25: 1152–1164
  • Bartram MP, Amendola E, Benzing T, Schermer B, de Vita G, Muller RU (2016). Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure. BMC Mol Biol. 17: 11
  • Benzing T (2016). Hypertension: Testing for pre-eclampsia: paving the way to early diagnosis. Nat Rev Nephrol. 12: 200–202
  • Borgal L, Rinschen MM, Dafinger C, Liebrecht VI, Abken H, Benzing T, Schermer B (2016). Jade-1S phosphorylation induced by CK1alpha contributes to cell cycle progression. Cell Cycle. 15: 1034–1045
  • Braun F, Rinschen MM, Bartels V, Frommolt P, Habermann B, Hoeijmakers JHJ, Schumacher B, Dolle MET, Muller R-U, Benzing T, Schermer B, Kurschat CE (2016). Altered lipid metabolism in the aging kidney identified by three layered omic analysis. Aging. Albany NY, 8: 441–457
  • Gandhirajan RK, Jain M, Walla B, Johnsen M, Bartram MP, Huynh Anh M, Rinschen MM, Benzing T, Schermer B (2016). Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ). J Biol Chem. 291: 11596–11607
  • Gansevoort RT, Arici M, Benzing T, Birn H, Capasso G, Covic A, Devuyst O, Drechsler C, Eckardt K-U, Emma F, Knebelmann B, Le Meur Y, Massy ZA, Ong ACM, Ortiz A, Schaefer F, Torra R, Vanholder R, Wiecek A, Zoccali C, Van Biesen W (2016). Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney  disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice. Nephrol Dial Transplant. 31: 337–348
  • Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Brauniger R, Rinschen MM, Volker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB (2016). A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight
  • Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kuhne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F (2016). mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells. J Am Soc Nephrol
  • Ising C, Bharill P, Brinkkoetter S, Brahler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Hohne M, Muller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT (2016). Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier. Am J Pathol. 186: 1128–1139
  • Johnsen M, Späth M, Denzel M, Göbel H, Kubacki T, Hoyer K, Hinze Y, Benzing T, Schermer B, Antebi A, Burst V, Müller R (2016). Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage. PLoS ONE. 11: e0161315
  • Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT (2016). Par3A is dispensable for the function of the glomerular filtration barrier of the kidney. Am J Physiol Renal Physiol. 311: F112-119
  • Koehler S, Brähler S, Kuczkowski A, Binz J, Hackl M, Hagmann H, Höhne M, Vogt M, Wunderlich C, Wunderlich F, Schweda F, Schermer B, Benzing T, Brinkkoetter P (2016). Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion. Sci Rep. 6: 35400
  • Laghmani K, Beck BB, Yang S-S, Seaayfan E, Wenzel A, Reusch B, Vitzthum H, Priem D, Demaretz S, Bergmann K, Duin LK, Gobel H, Mache C, Thiele H, Bartram MP, Dombret C, Altmuller J, Nurnberg P, Benzing T, Levtchenko E, Seyberth HW, Klaus G, Yigit G, Lin S-H, Timmer A, de Koning TJ, Scherjon SA, Schlingmann KP, Bertrand MJM, Rinschen MM, de Backer O, Konrad M, Komhoff M (2016). Polyhydramnios, Transient Antenatal Bartter’s Syndrome, and MAGED2 Mutations. N Engl J Med. 374: 1853–1863
  • Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT (2016). Quantitative deep-mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation. Am J Physiol Cell Physiol. ajpcell.00121.2016
  • Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Hohne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Muller R-U, Kruger M, Benzing T (2016). The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet. 25: 1328–1344
  • Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engstrom Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkotter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Bruning JC (2016). AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell. 165: 125–138
  • Thadhani R, Hagmann H, Schaarschmidt W, Roth B, Cingoez T, Karumanchi SA, Wenger J, Lucchesi KJ, Tamez H, Lindner T, Fridman A, Thome U, Kribs A, Danner M, Hamacher S, Mallmann P, Stepan H, Benzing T (2016). Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia. J Am Soc Nephrol. 27: 903–913
  • Schermer B, Benzing T (2016). Endothelial cilia protect against atherosclerosis. EMBO Rep. 17: 125–126
  • Scholz P, Auler M, Brachvogel B, Benzing T, Mallman P, Streichert T, Klatt AR (2016). Detection of multiple annexin autoantibodies in a patient with recurrent miscarriages, fulminant stroke and seronegative antiphospholipid syndrome. Biochem Med. Zagreb, 26: 272–278

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Matteo Bergami

  • Bergami M (2016). Experience-dependent plasticity of adult-born neuron connectivity. Commun Intreg Biol. 8, e1038444
  • Klionsky DJ, et al (2016). Guidelines for the use and interpretation assays for monitoring autophagy (3rd edition). Autophagy.DOI:10.1080/15548627.2015.1100356
  • McAvoy KM, Scobie KN, Berger S, Russo C, Nannan G, Decharatanachart P, Vega-Ramirez H, Miake-Lye S, Whalen M, Nelson M, Bergami M, Bartsch D, Hen R, Berninger B, Sahay A (2016). Modulating neuronal competition dynamics in the dentate gyrus to rejuvenate aging memory circuits. Neuron. 91, 1-18

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Andreas Beyer

  • Liu Y, Beyer A, Aebersold R (2016). On the dependency of cellular protein levels on mRNA abundance. Cell. 165(3):535-50
  • Seifert M, Friedrich B, Beyer A (2016). Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis. Genome Biol. 3;17(1):204

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Susanne Brodesser

  • Stoffel W, Hammels I, Jenke B, Binczek E, Schmidt-Soltau I, Brodesser S, Schauss A, Etich J, Heilig J, Zaucke F. (2016) Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition. Cell Death Dis 7(11):e2488
  • Ali NJ, Dias Gomes M, Bauer R, Brodesser S, Niemann C, Iden S. (2016) Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance. J Invest Dermatol 136(12):2406-16
  • Oliverio M, Schmidt E, Mauer J, Baitzel C, Hansmeier N, Khani S, Konieczka S, Pradas-Juni M, Brodesser S, Van T-M, Bartsch D, Brönneke HS, Heine M, Hilpert H, Tarcitano E, Garinis GA, Frommolt P, Heeren J, Mori MA, Brüning JC, Kornfeld J-W. (2016) Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function. Nat Cell Biol 18(3):328-36

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Jens Brüning

  • Burnett CJ, Li C, Webber E, Tsaousidou E, Xue SY, Brüning JC, Krashes MJ (2016). Hunger-Driven Motivational State Competition. Neuron. 2016 Oct 5;92(1):187-201. doi: 10.1016/j.neuron.2016.08.032
  • Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R (2016). Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue. Cell Rep. 2016 Oct 18;17(4):1008-1021. doi: 10.1016/j.celrep.2016.09.053
  • Hausen AC, Ruud J, Jiang H, Hess S, Varbanov H, Kloppenburg P, Brüning JC (2016). Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity. Cell Rep. 2016 Dec 6;17(10):2512-2521. doi: 10.1016/j.celrep.2016.11.030
  • Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC (2016). Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 Aug 25;166(5):1338-1340. doi: 10.1016/j.cell.2016.08.010. No abstract available
  • Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC (2016). Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell. May 5; 165(4):882-895
  • Kühn AB, Feis D-L, Schilbach L, Kracht LW, Hess ME, Mauer J, Brüning JC, Tittgemeyer M (2016). FTO gene variant modulates the neural correlates of visual food perception. Neuroimage. Mar;128: 21-31
  • Oliverio M, Schmidt E, Mauer J, Baitzel C, Hansmeier H, Khani S, Konieczka S, Pradas-Juni M, Brodesser S, Van TM, Bartsch D, Brönneke HS, Heine M, Hilpert H, Tarcitano E, Garinis GA, Frommolt P, Heeren J, Mori MA, Brüning JC, Kornfeld JW (2016). Dicer1-miR-328-Bace1 signaling controls brown adipose tissue differentiation and function. Nat Cell Biol. Mar; 18(3):328-336
  • Ruud J, Brüning JC (2016). Neuroendocrinology: Electromagnetogenetic Control over Feeding and Glucose Metabolism. Curr Biol. Jun 6; 11:R470-R473
  • Schmitz J, Evers N, Awazawa M, Nicholls HT, Brönneke HS, Dietrich A, Mauer J, Blüher M, Brüning JC (2016). Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss. Mol Met. Jan 11;5(5):328-339
  • Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess M, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Benzing T, Rahmouni K, Wunderlich T, Kloppenburg P, Brüning JC (2016). AgRP-neurons control systemic insulin sensitivity via myostatin-expression in brown-adipose tissue. * Equal contributions. Cell. Mar 24;165(1):125-138
  • Steculorum SM, Brüning JC (2016). Sweet mitochondrial dynamics in VMH neurons. Cell Metab. Apr 12; 23(4): 577-579
  • Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, Gerhardt H, Carmeliet P, Potente M (2016). FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. Jan 14, 529(7):216-220

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Oliver Cornely

  • Biehl LM, Schmidt-Hieber M, Liss B, Cornely OA, Vehreschild MJ (2016). Colonization and infection with extended spectrum beta-lactamase producing Enterobacteriaceae in high-risk patients - Review of the literature from a clinical perspective. Crit Rev Microbiol. 42(1):1-16
  • Boch T, Spiess B, Cornely OA, Vehreschild JJ, Rath PM, Steinmann J, Heinz WJ, Hahn J, Krause SW, Kiehl MG, Egerer G, Liebregts T, Koldehoff M, Klein M, Nolte F, Mueller MC, Merker N, Will S, Mossner M, Popp H, Hofmann WK, Reinwald M, Buchheidt D (2016). Diagnosis of invasive fungal infections in haematological patients by combined use of galactomannan, 1,3-β-D-glucan, Aspergillus PCR, multifungal DNA-microarray, and Aspergillus azole resistance PCRs in blood and bronchoalveolar lavage samples: results of a prospective multicentre study. Clin Microbiol Infect. 2016 Oct;22(10):862-868. doi: 10.1016/j.cmi.2016.06.021
  • Cornely OA, Vehreschild MJ (2016). Where to Place the New Treatments for Clostridium difficile Infection? Clin Infect Dis. 2016 Sep 15;63(6):735-6. doi: 10.1093/cid/ciw366. Epub 2016 Jun 30
  • Cornely OA, Maher RM, Marty FM, Lee M, Vehreschild JJ, Vehreschild MJ (2016). The VITAL study: case control studies are hypothesis-generating - Authors' reply. Lancet Infect Dis. 16(8):886-7
  • Cornely OA, Duarte RF, Haider S, Chandrasekar P, Helfgott D, Jimenez JL, et al (2016). Phase 3 pharmacokinetics and safety study of a posaconazole tablet formulation in patients at risk for invasive fungal disease. J Antimicrob Chemother. 71(3):718-26
  • Cornely OA, Duarte RF, Haider S, Chandrasekar P, Helfgott D, Jimenez JL, et al (2016). Phase 3 pharmacokinetics and safety study of a posaconazole tablet formulation in patients at risk for invasive fungal disease. J Antimicrob Chemother. 71(6):1747
  • Farowski F, Cornely OA, Hartmann P (2016). High Intracellular Concentrations of Posaconazole Do Not Impact on Functional Capacities of Human Polymorphonuclear Neutrophils and Monocyte-Derived Macrophages In Vitro. Antimicrob Agents Chemother. 60(6):3533-9
  • Fischer J, Hamacher L, Fries J, Hallek M, Cornely OA, Kochanek M, et al (2016). Rhodotorula mucilaginosa as a cause of recurrent pulmonary infection and liver infiltration in a patient with CLL. Ann Hematol. 95(9):1569-70
  • Gerding DN, Hecht DW, Louie T, Nord CE, Talbot GH, Cornely OA, et al (2016). Susceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection. J Antimicrob Chemother. 71(1):213-9
  • Hagel S, Fischer A, Ehlermann P, Frank T, Tueffers K, Sturm A, Link A, Demir M, Siebenhaar A, Storr M, Glueck T, Siegel E, Solbach P, Goeser F, Koelbel CB, Lohse A, Luebbert C, Kandzi U, Maier M, Schuerle S, Lerch MM, Tacke D, Cornely OA, Stallmach A, Vehreschild M, German Clinical Microbiome Study Group (GCMSG) (2016). Fecal Microbiota Transplant in Patients With Recurrent Clostridium Difficile Infection. Dtsch Arztebl Int. 2016 Sep 5;113(35-36):583-9. doi: 10.3238/arztebl.2016.0583
  • Higgins PG, Koehler D, Chan JZ, Cornely OA, Fätkenheuer G, Gillis M, Pallen MJ, Tien J, Seifert H, Vehreschild MJ, Millard AD (2016). Draft Genome Sequences of Nine Clinical Isolates of Vancomycin-Resistant Enterococci. Genome Announc. 2016 Aug 18;4(4). pii: e00803-16. doi: 10.1128/genomeA.00803-16
  • Hurraß J, Heinzow B, Aurbach U, Bergmann KC, Bufe A, Buzina W, Cornely OA, Engelhart S, Fischer G, Gabrio T, Heinz W, Herr CE, Kleine-Tebbe J, Klimek L, Köberle M, Lichtnecker H, Lob-Corzilius T, Merget R, Mülleneisen N, Nowak D, Rabe U, Raulf M, Seidl HP, Steiß JO, Szewszyk R, Thomas P, Valtanen K, Wiesmüller GA (2016). Medical diagnostics for indoor mold exposure. Int J Hyg Environ Health. 2016 Dec 5. pii: S1438-4639(16)30561-2. doi: 10.1016/j.ijheh.2016.11.012. Epub 2016 Dec 5. Review
  • Koehler P, Tacke D, Cornely OA (2016). Bone and joint infections by Mucorales, Scedosporium, Fusarium and even rarer fungi. Crit Rev Microbiol. 42(1):158-71
  • Koehler P, Cornely OA (2016). Contemporary Strategies in the Prevention and Management of Fungal Infections. Infect Dis Clin North Am. 30(1):265-75
  • Liss B, Cornely OA, Hoffmann D, Dimitriou V, Wisplinghoff H (2016). 1,3-beta-d-Glucan contamination of common antimicrobials. J Antimicrob Chemother. 71(4):913-5
  • Liss B, Cornely OA, Hoffmann D, Dimitriou V, Wisplinghoff H (2016). 1,3-ss-D-glucan concentrations in blood products predict false positive post-transfusion results. Mycoses. 59(1):39-42
  • Liss B, Cornely OA (2016). Burden and benefit of antibiotic prophylaxis in cancer chemotherapy. Lancet Infect Dis. 16(6):640
  • Maertens JA, Raad, II, Marr KA, Patterson TF, Kontoyiannis DP, Cornely OA, et al (2016). Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial. Lancet. 387(10020):760-9
  • Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR, 3rd, et al (2016). Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis. Lancet Infect Dis. 16(7):828-37
  • Pana ZD, Seidel D, Skiada A, Groll AH, Petrikkos G, Cornely OA, Roilides E, Collaborators of Zygomyco.net and/or FungiScope™ Registries (2016). Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries. BMC Infect Dis. 2016 Nov 10;16(1):667
  • Pflug N, Kluth S, Vehreschild JJ, Bahlo J, Tacke D, Biehl L, et al (2016). Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota. Oncoimmunology. 5(6):e1150399
  • Schweer KE, Jakob B, Liss B, Christ H, Fischer G, Vehreschild M, et al (2016). Domestic mould exposure and invasive aspergillosis-air sampling of Aspergillus spp. spores in homes of hematological patients, a pilot study. Med Mycol. 54(6):576-83
  • Simon ST, Kloke M, Alt-Epping B, Gärtner J, Hellmich M, Hein R, Piel M, Cornely OA, Nauck F, Voltz R (2016). EffenDys-Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Patients With Advanced Cancer: A Multicenter, Open-Label, Randomized, Morphine-Controlled, Crossover, Phase II Trial. J Pain Symptom Manage. 2016 Nov;52(5):617-625. doi: 10.1016/j.jpainsymman.2016.05.023
  • Thompson GR, 3rd, Rendon A, Ribeiro Dos Santos R, Queiroz-Telles F, Ostrosky-Zeichner L, Azie N, et al (2016). Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses. Clin Infekt Dis. 63(3):356-62 
  • Vehreschild MJ, Cornely OA (2016). Fecal Microbiota Transfer 2.0. J Infect Dis. 214(2):169-70
  • Wiesmüller GA, Heinzow B, Aurbach U, Bergmann KC, Bufe A, Buzina W, Cornely OA, Engelhart S, Fischer G, Gabrio T, Heinz W, Herr CE, Kleine-Tebbe J, Klimek L, Köberle M, Lichtnecker H, Lob-Corzilius T, Merget R, Mülleneisen N, Nowak D, Rabe U, Raulf M, Seidl HP, Steiß JO, Szewszyk R, Thomas P, Valtanen K, Hurraß J (2016). Medical Diagnostics for Mold Exposure Indoors. Pneumologie. 2016 Nov;70(11):699-741. German. No abstract available.

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Constantinos Demetriades 

  • Tsokanos F, Albert MA, Demetriades C, Spirohn K, Boutros M, Teleman AA (2016). eIF4A inactivates TORC1 in response to amino acid starvation. EMBO J.2016 Mar 17;35(10):1058-76  
  • Demetriades C, Plescher M, Teleman AA (2016). Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016 Feb 12;7:10662

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Martin Denzel

  • Johnsen M, Späth MR, Denzel MS, Göbel H, Kubacki T, Hoyer KJR, Hinze Y, Benzing T, Schermer B, Antebi A, Burst V, Müller RU (2016). Oral supplementation of glucosamine fails to alleviate acute kidney injury in renal ischemia-reperfusion damage. PLoS ONE. 2016 Aug 24;11(8):e0161315. doi: 10.1371/journal.pone.0161315. eCollection 2016
  • Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Marinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE (2016). Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16

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Sabine Eming

  • Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA (2016). mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 27;7:13226
  • Do N, Eming SA (2016). Skin fibrosis: mechanisms and models. Current Research in Translational Medicine. In Press
  • Eckes B, Eming SA (2016). Tissue fibrosis: a pathomechanistically unresolved challenge and scary clinical problem. Exp Dermatol. In Press
  • Eming SA, Wlaschek M, Scharffetter-Kochanek K (2016). Wound healing in the elderly. Der Hautarzt. 67:112-6
  • Hos D, Bucher F, Regenfuss B, Dreisow M, Bock F, Heindl LM, Eming SA, Cursiefen C (2016). Interleukin-10 indirectly regulates corneal lymphangiogenesis and resolution of inflammation via macrophages. Am J Pathol. 186:159-71
  • Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich A, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster  CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC (2016). Myeloid cell-derived VEGF is required to maintain brain glucose uptake and to limit cognitive impairment in obesity. Cell. 165:882-895
  • Kakanj P, Moussian B, Grönke S, Bustos V, Eming SA, Partridge L, Leptin M (2016). Role of insulin and TOR signalling in wound healing. Nat Commun. 7;7:12972
  • Kirsner RS, Vanscheidt W, Keast DH, Lantis JC 2nd, Dove CR, Cazzell SM, Vartivarian M, Augustin M, Marston WA, McCoy ND, Cargill DI, Lee TD, Dickerson JE Jr, Slade HB; HP802-247 Study Group (2016). Phase 3 Evaluation of HP802-247 in the Treatment of Chronic Venous Leg Ulcers. Wound Rep Regen
  • Kreft S, Klatt A, Straßburger J, Pöschl E, Flowers R, Eming SA, Reutelingsperger C, Brisson A, Brachvogel B (2016). Skin wound repair is not altered in the absence of endogenous AnxA1 or AnxA5 but pharmacological concentrations of AnxA4 and AnxA5 inhibit wound hemostasis. Cells Tissues Organs. 201:287-298
  • ManiuC, KobeC, SchlaakM, MauchC, EmingSA (2016). Polymyalgia rheumatica occurring during treatment with ipilimumab. Eur J Dermatol. In Press
  • Peters F, Batinica M, Plum G, Eming SA, Fabri M (2016). Bug or no bug: challenges in diagnosing cutaneous mycobacterial infections. J Dtsch Dermatol Ges. 2016 Dec;14(12):1227-1235. doi: 10.1111/ddg.13001. Epub 2016 Jul 22

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Lukas P. Frenzel

  • Faitschuk E, Hombach AA, Frenzel LP, Wendtner CM, Abken H (2016). Chimeric antigen receptor T cells targeting Fc μ receptor selectively eliminate CLL cells while sparing healthy B cells. Blood. 2016 Sep 29;128(13):1711-22. doi: 10.1182/blood-2016-01-692046
  • Frenzel LP, Reinhardt HC, Pallasch CP (2016). Concepts of Chronic Lymphocytic Leukemia Pathogenesis: DNA Damage Response and Tumor Microenvironment. Oncol Res Treat. 2016;39(1-2):9-16. doi: 10.1159/000443820. Review
  • Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L; German International Cancer Genome Consortium Molecular Mechanisms in Malignant Lymphoma by Sequencing Project Consortium., Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC (2016). B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice. Blood. 2016 Jun 2;127(22):2732-41. doi: 10.1182/blood-2015-11-684183

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Martin Graef

  • Graef M (2016). A dividing matter: Drp1/Dnm1-independent mitophagy. J Cell Biol. DOI: 10.1083/jcb.201611079
  • Klionsky DJ, et al., Graef M, et al. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12, 1-222
  • Velázquez AP, Graef M (2016). Autophagy regulation depends on ER homeostasis controlled by lipid droplets. Autophagy. 12, 1409-1410
  • Velázquez AP, Tatsuta T, Ghillebert R, Drescher I, Graef M (2016). Lipid droplet-mediated ER homeostasis regulates autophagy and cell survival during starvation. J Cell Biol. 212, 621-631

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Michael Hallek

  • Brown JR, Hallek MJ, Pagel, JM (2016). Chemoimmunotherapy Versus Targeted Treatment in Chronic Lymphocytic Leukemia: When, How Long, How Much, and in Which Combination? Am Soc Clin Oncol. 35, e387-398
  • Buhler A, Wendtner CM, Kipps TJ, Rassenti L, Fraser GA, Michallet AS, Hillmen P, Durig J, Gregory SA, Kalaycio M, Aurran-Schleinitz T, Trentin L, Gribben JG, Chanan-Khan A, Purse B, Zhang J, De Bedout S, Mei J, Hallek M, Stilgenbauer S (2016). Lenalidomide treatment and prognostic markers in relapsed or refractory chronic lymphocytic leukemia: data from the prospective, multicenter phase-II CLL-009 trial. Blood Cancer Journal. 6, e404
  • Chanan-Khan A, Cramer P, Demirkan F, Fraser G, Silva RS, Grosicki S, Pristupa A, Janssens A, Mayer J, Bartlett NL, Dilhuydy MS, Pylypenko H, Loscertales J, Avigdor A, Rule S, Villa D, Samoilova O, Panagiotidis P, Goy A, Mato A, Pavlovsky MA, Karlsson C, Mahler M, Salman M, Sun S, Phelps C, Balasubramanian S, Howes A, Hallek M, investigators H (2016). Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study. Lancet Oncol. 17, 200-211
  • Craddock C, Labopin M, Robin M, Finke J, Chevallier P, Yakoub-Agha I, Bourhis JH, Sengelov H, Blaise D, Luft T, Hallek M, Kroger N, Nagler A, Mohty M (2016). Clinical activity of azacitidine in patients who relapse after allogeneic stem cell transplantation for acute myeloid leukemia. Haematologica. 101, 879-883
  • Cramer P, Hallek M, Eichhorst B (2016). State-of-the-Art Treatment and Novel Agents in Chronic Lymphocytic Leukemia. Oncol Res Treat. 39, 25-32
  • Cramer P, Langerbeins P, Hallek M (2016). Combination of Targeted Drugs to Control Chronic Lymphocytic Leukemia: Harnessing the Power of New Monoclonal Antibodies in Combination With Ibrutinib. Cancer Journal. 22, 62-66
  • Cramer P, Langerbeins P, Eichhorst B, Hallek M (2016). Advances in first-line treatment of chronic lymphocytic leukemia: current recommendations on management and first-line treatment by the German CLL Study Group (GCLLSG). Eur J Haematol. 96, 9-18
  • Cramer P, Langerbeins P, Fischer K, Eichhorst B, Hallek M, Goede V (2016). Dose-reduced fludarabine, cyclophosphamide and rituximab (FCR) in older patients with chronic lymphocytic leukemia: does one size fit all? Leuk Lymphoma. 57, 987-990
  • Dietrich S, Pircher A, Endris V, Peyrade F, Wendtner CM, Follows GA, Hullein J, Jethwa A, Ellert E, Walther T, Liu X, Dyer MJ, Elter T, Brummer T, Zeiser R, Hermann M, Herold M, Weichert W, Dearden C, Haferlach T, Seiffert M, Hallek M, von Kalle C, Ho AD, Gaehler A, Andrulis M, Steurer M, Zenz T (2016). BRAF inhibition in hairy cell leukemia with low-dose vemurafenib. Blood. 127, 2847-2855
  • Eichhorst B, Cramer P, Hallek M (2016). Initial therapy of chronic lymphocytic leukemia. Semin Oncol. 43, 241-250
  • Eichhorst B, Fink AM, Bahlo J, Busch R, Kovacs G, Maurer C, Lange E, Koppler H, Kiehl M, Sokler M, Schlag R, Vehling-Kaiser U, Kochling G, Ploger C, Gregor M, Plesner T, Trneny M, Fischer K, Dohner H, Kneba M, Wendtner CM, Klapper W, Kreuzer KA, Stilgenbauer S, Bottcher S, Hallek M, International group of i, German CLLSG (2016). First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): an international, open-label, randomised, phase 3, non-inferiority trial. Lancet Oncol. 17, 928-942
  • Eichhorst B, Hallek M, Goede V (2016). New treatment approaches in CLL: Challenges and opportunities in the elderly. J Geriatr Oncol
  • Fischer K, Bahlo J, Fink AM, Goede V, Herling CD, Cramer P, Langerbeins P, von Tresckow J, Engelke A, Maurer C, Kovacs G, Herling M, Tausch E, Kreuzer KA, Eichhorst B, Bottcher S, Seymour JF, Ghia P, Marlton P, Kneba M, Wendtner CM, Dohner H, Stilgenbauer S, Hallek M (2016). Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial. Blood. 127, 208-215
  • Freeman CL, Dixon M, Houghton R, Kreuzer KA, Fingerle-Rowson G, Herling M, Humphrey K, Bottcher S, de Costa CS, Iglesias V, Stilgenbauer S, Gribben J, Hallek M, Goede V (2016). Role of CD20 expression and other pre-treatment risk factors in the development of infusion-related reactions in patients with CLL treated with obinutuzumab. Leukemia. 30, 1763-1766
  • Goede V, Bahlo J, Chataline V, Eichhorst B, Durig J, Stilgenbauer S, Kolb G, Honecker F, Wedding U, Hallek M (2016). Evaluation of geriatric assessment in patients with chronic lymphocytic leukemia: Results of the CLL9 trial of the German CLL study group. Leuk Lymphoma. 57, 789-796
  • Hansen HP, Trad A, Dams M, Zigrino P, Moss M, Tator M, Schon G, Grenzi PC, Bachurski D, Aquino B, Durkop H, Reiners KS, von Bergwelt-Baildon M, Hallek M, Grotzinger J, Engert A, Paes Leme AF, Pogge von Strandmann E (2016). CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin, in vitro. Oncotarget. 7, 30523-30535
  • Herling CD, Klaumunzer M, Rocha CK, Altmuller J, Thiele H, Bahlo J, Kluth S, Crispatzu G, Herling M, Schiller J, Engelke A, Tausch E, Dohner H, Fischer K, Goede V, Nurnberg P, Reinhardt HC, Stilgenbauer S, Hallek M, Kreuzer KA (2016). Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy. Blood. 128, 395-404
  • Hermine O, Hoster E, Walewski J, Bosly A, Stilgenbauer S, Thieblemont C, Szymczyk M, Bouabdallah R, Kneba M, Hallek M, Salles G, Feugier P, Ribrag V, Birkmann J, Forstpointner R, Haioun C, Hanel M, Casasnovas RO, Finke J, Peter N, Bouabdallah K, Sebban C, Fischer T, Duhrsen U, Metzner B, Maschmeyer G, Kanz L, Schmidt C, Delarue R, Brousse N, Klapper W, Macintyre E, Delfau-Larue MH, Pott C, Hiddemann W, Unterhalt M, Dreyling M, European Mantle Cell Lymphoma N (2016). Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network. Lancet. 388, 565-575
  • Holtick U, Chemnitz JM, Shimabukuro-Vornhagen A, Theurich S, Chakupurakal G, Krause A, Fiedler A, Luznik L, Hellmich M, Wolf D, Hallek M, von Bergwelt-Baildon M, Scheid C (2016). OCTET-CY: a phase II study to investigate the efficacy of post-transplant cyclophosphamide as sole graft-versus-host prophylaxis after allogeneic peripheral blood stem cell transplantation. Eur J Haematol. 96, 27-35
  • Holtick U, Shimabukuro-Vornhagen A, Chakupurakal G, Theurich S, Leitzke S, Burst A, Hallek M, von Bergwelt-Baildon M, Scheid C, Chemnitz JM (2016). FLAMSA reduced-intensity conditioning is equally effective in AML patients with primary induction failure as well as in first or second complete remission. Eur J Haematol. 96, 475-482
  • Holtick U, Shimabukuro-Vornhagen A, Chakupurakal G, Theurich S, Leitzke S, Burst A, Hoster E, Rosenwald A, Berger F, Bernd HW, Hartmann S, Loddenkemper C, Barth TF, Brousse N, Pileri S, Rymkiewicz G, Kodet R, Stilgenbauer S, Forstpointner R, Thieblemont C, Hallek M, Coiffier B, Vehling-Kaiser U, Bouabdallah R, Kanz L, Pfreundschuh M, Schmidt C, Ribrag V, Hiddemann W, Unterhalt M, Kluin-Nelemans JC, Hermine O, Dreyling MH, Klapper W (2016). Prognostic Value of Ki-67 Index, Cytology, and Growth Pattern in Mantle-Cell Lymphoma: Results From Randomized Trials of the European Mantle Cell Lymphoma Network. J Clin Oncol. 34, 1386-1394
  • Kovacs G, Robrecht S, Fink AM, Bahlo J, Cramer P, von Tresckow J, Maurer C, Langerbeins P, Fingerle-Rowson G, Ritgen M, Kneba M, Dohner H, Stilgenbauer S, Klapper W, Wendtner CM, Fischer K, Hallek M, Eichhorst B, Bottcher S (2016). Minimal Residual Disease Assessment Improves Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia (CLL) Who Achieve Partial Response: Comprehensive Analysis of Two Phase III Studies of the German CLL Study Group. J Clin Oncol. In press
  • Kutsch N, Busch R, Bahlo J, Mayer J, Hensel M, Hopfinger G, Hess G, von Grunhagen U, Wendtner CM, Maria Fink A, Fischer K, Hallek M, Eichhorst B (2016). FCR front-line therapy and quality of life in patients with chronic lymphocytic leukemia. Leuk Lymphoma. 1-9
  • Lilienthal N, Lohmann G, Crispatzu G, Vasyutina E, Zittrich S, Mayer P, Herling CD, Tur MK, Hallek M, Pfitzer G, Barth S, Herling M (2016). A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells. Mol Cancer Ther. 2016 May;15(5):971-84. doi: 10.1158/1535-7163.MCT-15-0685. Epub 2016 Jan 29
  • Maurer C, Langerbeins P, Bahlo J, Cramer P, Fink AM, Pflug N, Engelke A, von Tresckow J, Kovacs G, Stilgenbauer S, Wendtner CM, Muller L, Ritgen M, Seiler T, Fischer K, Hallek M, Eichhorst B (2016). Effect of first-line treatment on second primary malignancies and Richter's transformation in patients with CLL. Leukemia. 2016 Oct;30(10):2019-2025. doi: 10.1038/leu.2016.113. Epub 2016 May 2
  • Muller D, Fischer K, Kaiser P, Eichhorst B, Walshe R, Reiser M, Kellermann L, Borsi L, Civello D, Mensch A, Bahlo J, Hallek M, Stock S, Fingerle-Rowson G (2016). Cost-effectiveness of rituximab in addition to fludarabine and cyclophosphamide (R-FC) for the first-line treatment of chronic lymphocytic leukemia. Leuk Lymphoma. 57, 1130-1139
  • Nguyen PH, Fedorchenko O, Rosen N, Koch M, Barthel R, Winarski T, Florin A, Wunderlich FT, Reinart N, Hallek M (2016). LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia. Cancer Cell. 2016 Oct 10;30(4):610-622. doi: 10.1016/j.ccell.2016.09.007
  • O'Brien S, Jones JA, Coutre SE, Mato AR, Hillmen P, Tam C, Osterborg A, Siddiqi T, Thirman MJ, Furman RR, Ilhan O, Keating MJ, Call TG, Brown JR, Stevens-Brogan M, Li Y, Clow F, James DF, Chu AD, Hallek M, Stilgenbauer S (2016). Ibrutinib for patients with relapsed or refractory chronic lymphocytic leukaemia with 17p deletion (RESONATE-17): a phase 2, open-label, multicentre study. Lancet Oncol
  • Pflug N, Kluth S, Vehreschild JJ, Bahlo J, Tacke D, Biehl L, Eichhorst B, Fischer K, Cramer P, Fink AM, von Bergwelt-Baildon M, Stilgenbauer S, Hallek M, Cornely OA, Vehreschild MJ (2016). Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota. Oncoimmunology. 5, e1150399
  • Pohlen M, Thoennissen NH, Braess J, Thudium J, Schmid C, Kochanek M, Kreuzer KA, Lebiedz P, Gorlich D, Gerth HU, Rohde C, Kessler T, Muller-Tidow C, Stelljes M, Buchner T, Schlimok G, Hallek M, Waltenberger J, Hiddemann W, Berdel WE, Heilmeier B, Krug U (2016). Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction. PLoS One. 11, e0160871
  • Rawstron AC, Fazi C, Agathangelidis A, Villamor N, Letestu R, Nomdedeu J, Palacio C, Stehlikova O, Kreuzer KA, Liptrot S, O'Brien D, de Tute RM, Marinov I, Hauwel M, Spacek M, Dobber J, Kater AP, Gambell P, Soosapilla A, Lozanski G, Brachtl G, Lin K, Boysen J, Hanson C, Jorgensen JL, Stetler-Stevenson M, Yuan C, Broome HE, Rassenti L, Craig F, Delgado J, Moreno C, Bosch F, Egle A, Doubek M, Pospisilova S, Mulligan S, Westerman D, Sanders CM, Emerson R, Robins HS, Kirsch I, Shanafelt T, Pettitt A, Kipps TJ, Wierda WG, Cymbalista F, Hallek M, Hillmen P, Montserrat E, Ghia P (2016). A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study. Leukemia. 30, 929-936
  • Rubio MT, Savani BN, Labopin M, Polge E, Niederwieser D, Ganser A, Schwerdtfeger R, Ehninger G, Finke J, Renate A, Craddock C, Kroger N, Hallek M, Jindra P, Mohty M, Nagler A (2016). The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years-a report from the EBMT acute leukemia working party. J Hematol Oncol. 9, 65
  • Sauer M, Schuldner M, Hoffmann N, Cetintas A, Reiners KS, Shatnyeva O, Hallek M, Hansen HP, Gasser S, von Strandmann EP (2016). CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells. Oncogene. 2017 Feb 16;36(7):933-941. doi: 10.1038/onc.2016.259. Epub 2016 Aug 1
  • Savani BN, Labopin M, Blaise D, Niederwieser D, Ciceri F, Ganser A, Arnold R, Afanasyev B, Vigouroux S, Milpied N, Hallek M, Cornelissen JJ, Schwerdtfeger R, Polge E, Baron F, Esteve J, Gorin NC, Schmid C, Giebel S, Mohty M, Nagler A (2016). Peripheral blood stem cell graft compared to bone marrow after reduced intensity conditioning regimens for acute leukemia: a report from the ALWP of the EBMT. Haematologica. 101, 256-262
  • Scheffold A, Jebaraj BM, Jaramillo S, Tausch E, Steinbrecher D, Hahn M, Bottcher S, Ritgen M, Bunjes D, Zeis M, Stadler M, Uharek L, Scheid C, Hegenbart U, Hallek M, Kneba M, Schmitz N, Dohner H, Dreger P, Stilgenbauer S (2016). Impact of telomere length on the outcome of allogeneic stem cell transplantation for poor-risk chronic lymphocytic leukaemia: results from the GCLLSG CLL3X trial. Br J Haematol.  2016 Jul 8. doi: 10.1111/bjh.14219. [Epub ahead of print]
  • Schlosser HA, Drebber U, Kloth M, Thelen M, Rothschild SI, Haase S, Garcia-Marquez M, Wennhold K, Berlth F, Urbanski A, Alakus H, Schauss A, Shimabukuro-Vornhagen A, Theurich S, Warnecke-Ebertz U, Stippel DL, Zippelius A, Buttner R, Hallek M, Holscher AH, Zander T, Monig SP, von Bergwelt-Baildon M (2016). Immune checkpoints programmed death 1 ligand 1 and cytotoxic T lymphocyte associated molecule 4 in gastric adenocarcinoma. Oncoimmunology. 5, e1100789
  • Shimabukuro-Vornhagen A, Garcia-Marquez M, Fischer RN, Iltgen-Breburda J, Fiedler A, Wennhold K, Rappl G, Abken H, Lehmann C, Herling M, Wolf D, Fatkenheuer G, Rubbert-Roth A, Hallek M, Theurich S, von Bergwelt-Baildon M (2016). Antigen-presenting human B cells are expanded in inflammatory conditions. J Leukoc Biol. 2017 Feb;101(2):577-587. doi: 10.1189/jlb.5A0416-182R. Epub 2016 Aug 17
  • Stilgenbauer S, Eichhorst B, Schetelig J, Coutre S, Seymour JF, Munir T, Puvvada SD, Wendtner CM, Roberts AW, Jurczak W, Mulligan SP, Bottcher S, Mobasher M, Zhu M, Desai M, Chyla B, Verdugo M, Enschede SH, Cerri E, Humerickhouse R, Gordon G, Hallek M, Wierda WG (2016). Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study. Lancet Oncol. 17, 768-778
  • Tahmaz V, Gehlsen U, Sauerbier L, Holtick U, Engel L, Radojska S, Petrescu-Jipa VM, Scheid C, Hallek M, Gathof B, Cursiefen C, Steven P (2016). Treatment of severe chronic ocular graft-versus-host disease using 100% autologous serum eye drops from a sealed manufacturing system: a retrospective cohort study. BR J Ophthalmology. 2016 Jun 6. pii: bjophthalmol-2015-307666. doi: 10.1136/bjophthalmol-2015-307666. [Epub ahead of print]
  • Theurich S, Schlaak M, Steguweit H, Heukamp LC, Wennhold K, Kurschat P, Rabenhorst A, Hartmann K, Schlosser H, Shimabukuro-Vornhagen A, Holtick U, Hallek M, Stadler R, von Bergwelt-Baildon M (2016). Targeting Tumor-Infiltrating B Cells in Cutaneous T-Cell Lymphoma. J Clin Oncol. 34, e110-116
  • Thijssen R, Ter Burg J, Garrick B, van Bochove GG, Brown JR, Fernandes SM, Rodriguez MS, Michot JM, Hallek M, Eichhorst B, Reinhardt HC, Bendell J, Derks IA, van Kampen RJ, Hege K, Kersten MJ, Trowe T, Filvaroff EH, Eldering E, Kater AP (2016). Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. Blood. 128, 574-583
  • Weinhold M, Shimabukuro-Vornhagen A, Franke A, Theurich S, Wahl P, Hallek M, Schmidt A, Schinkothe T, Mester J, von Bergwelt-Baildon M, Bloch W (2016). Physical exercise modulates the homeostasis of human regulatory T cells. J Allergy Clin Immun. 137, 1607-1610 e1608
  • Wendtner CM, Hallek M, Fraser GA, Michallet AS, Hillmen P, Durig J, Kalaycio M, Gribben JG, Stilgenbauer S, Buhler A, Kipps TJ, Purse B, Zhang J, De Bedout S, Mei J, Chanan-Khan A (2016). Safety and efficacy of different lenalidomide starting doses in patients with relapsed or refractory chronic lymphocytic leukemia: results of an international multicenter double-blinded randomized phase II trial. Leuk Lymphoma. 57, 1291-1299

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Matthias Hammerschmidt

  • Hatzold J, Beleggia F, Herzig H, Altmüller J, Nürnberg P, Bloch W, Wollnik B, Hammerschmidt M (2016). Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. eLife. 5, e14277
  • Hosseinibarkooie S, Peters M, Torres-Benito L, Rastetter RH, Hupperich K, Hoffmann A, Mendoza-Ferreira N, Kaczmarek A, Janzen E, Milbradt J, Lamkemeyer T, Rigo F, Bennett CF, Guschlbauer C, Büschges A, Hammerschmidt M, Riessland M, Kye MJ, Clemen CS, Wirth B (2016). The power of human protective modifiers: PLS3 and CORO1C unravel impaired endocytosis in spinal muscular atrophy and rescue SMA phenotype. Am J Hum Genet. 99, 647-665
  • Jeradi S, Hammerschmidt M (2016). Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development. Development. 143, 1205-1216
  • Richardson R, Metzger M, Knyphausen P, Ramezani T, Kraus C, Schmelzer E, Hammerschmidt M (2016). Re-epithelialisation of cutaneous wounds in adult zebrafish uses a combination of mechanisms at play during wound closure in embryonic and adult mammals. Development. 143, 2077-208
  • Richardson R, Hammerschmidt M (2016). The role of Rho kinase (Rock) in re-epthelialization of adult zebrafish skin wounds. Small GTPases. [Epub ahead of print]

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Hans-Christian Hennies

  • Ammann S, Schulz A, Krägeloh-Mann I, Dieckmann N, Niethammer K, Fuchs S, Eckl KM, Plank R, Werner R, Altmüller J, Thiele H, Nürnberg P, Bank J, Strauß A, von Bernuth H, zur Stadt U, Grieve S, Griffiths G, Lehmberg K, Hennies HC, Ehl S (2016). A new type of Hermansky-Pudlak syndrome with immunodeficiency caused by mutations in AP3D1. Blood. 127:997-1006
  • Becker K, Siegert S, Reza Toliat M, Du J, Casper R, Dolmans GH, Werker PM, Tinschert S, Franke A, Gieger C, Strauch K, Nothnagel M, Nürnberg P, Hennies HC (2016). Meta-analysis of genome-wide association studies and network analysis-based integration with gene expression data identify new suggestive loci and unravel a wnt-centric network associated with Dupuytren’s disease. PLoS One.  11:e0158101 
  • Gruber R, Rainer G, Weiss A, Udvardi A, Thiele H, Eckl KM, Schupart R, Nürnberg P, Zschocke J, Schmuth M, Volc-Platzer B, Hennies HC (2016). Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations. Br J Dermatol. In press
  • Kapferer-Seebacher I, Pepin M, Werner R, Aitman T, Nordgren A, Stoiber H, Thielens N, Gaboriaud C, Amberger A, Schossig A, Gruber R, Giunta C, Bamshad M, Björck E, Chen C, Chitayat D, Dorschner M, Schmitt-Egenolf M, Hale CJ, Hanna D, Hennies HC, Heiss-Kisielewsky I, Lindstrand A, Lundberg P, Mitchell AL, Nickerson D, Reinstein E, Rohrbach M, Romani N, Schmuth M, Silver R, Taylan F, Vandersteen A, Vandrovcova J, Weerakkody R, Yang M, Pope FM, the Consortium “Molecular Basis of Periodontal EDS”, Byers PH, Schocke J (2016). Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement. Am J Hum Genet. 99:1005-1014 

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Marco Herling

  • Bachy E, Urb M, Chandra S, Robinot R, Bricard G, de Bernard S, Traverse-Glehen A, Gazzo S, Blond O, Khurana A, Baseggio L, Heavican T, Ffrench M, Crispatzu G, Mondière P, Schrader A, Taillardet M, Thaunat O, Martin N, Dalle S, Le Garff-Tavernier M, Salles G, Lachuer J, Hermine O, Asnafi V, Roussel M, Lamy T, Herling M, Iqbal J, Buffat L, Marche PN, Gaulard P, Kronenberg M, Defrance T, Genestier L (2016). CD1d-restricted peripheral T-cell lymphoma in mice and humans. J Exp Med. 2016 May 2;213(5):841-57
  • Crispatzu G, Schrader A, Nothnagel M, Herling M, Herling CD (2016). A critical evaluation of analytic aspects of gene expression profiling in lymphoid leukemias with broad applications to cancer genomics. AIMS Medical Science. 2016, 3(3): 248-271
  • Fischer K, Bahlo J, Fink AM, Goede V, Herling CD, Cramer P, Langerbeins P, von Tresckow J, Engelke A, Maurer C, Kovacs G, Herling M, Tausch E, Kreuzer KA, Eichhorst B, Böttcher S, Seymour JF, Ghia P, Marlton P, Kneba M, Wendtner CM, Döhner H, Stilgenbauer S, Hallek M (2016). Long term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial. Blood. 2016 Jan 14;127(2):208-15
  • Freeman C, Dixon M, Houghton R, Kreuzer KA, Fingerle-Rowson G, Herling M, Humphrey K, Böttcher S, Souza-Costa D, Iglesias VA, Stilgenbauer S, Gribben J, Hallek M, Goede V (2016). Role of CD20 expression and other pre-treatment risk factors in the development of infusion related reactions in patients with CLL treated with obinutuzumab. Leukemia. 2016 Aug;30(8):1763-6
  • Herling M, Schröder L, Awerkiew S, Chakupurakal G,Holtick U, Kaiser R, Pfister H, Scheid C, Di Cristanziano V (2016). Persistent CMV infection after allogeneic stem cell transplantation in a CMV-seronegative donor-to-positive recipient constellation: development of multidrug resistance in the absence of anti-viral cellular immunity. J Clin Virol. 2016 Jan;74:57-60
  • Herling CD, Klaumünzer M, Krings Rocha C, Altmüller J, Thiele H, Bahlo J, Kluth S, Crispatzu G, Herling M, Schiller J, Engelke A, Tausch E, Döhner H, Fischer K, Goede V, Nürnberg P, Reinhardt HC, Stilgenbauer S, Hallek M, Kreuzer KA (2016). Complex karyotypes, KRAS and POT1 mutations impact outcome in CLL after chlorambucil based chemo- or chemoimmunotherapy. Blood. 2016 Jul 21;128(3):395-404
  • LilienthalN, LohmannG, CrispatzuG, VasyutinaE, ZittrichS, MayerP, HerlingCD, Tur MK, HallekM, PfitzerG, BarthS, Herling M (2016). A novel recombinant anti-CD22 immunokinase delivers pro-apoptotic activity of death-associated protein kinase (DAPK) and mediates cytotoxicity in neoplastic B-cells. Mol Cancer Ther. 2016 May;15(5):971-84
  • Lohmann G, Vasyutina E, Bloehdorn J, Reinart N, Schneider J, Babu V, Knittel G, Crispatzu G, Mayer P, Prinz C‎, Biersack B, Efremov D, Chessa L, Herling CD, Stilgenbauer S, Hallek M, Schobert R, Reinhardt HC, Schumacher B‎, Herling M (2016). Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia. Leukemia. 2016 Oct 24. doi: 10.1038/leu.2016.294
  • Reiners KS, Shatnyeva O, Vasyutina E, Bösl T, Hansen HP, Hallek M, Herling M, Pogge von Strandmann (2016). Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNAs to bystander cells. Haematologica. 2016 Nov 17. pii: haematol.2016.153197. [Epub ahead of print]
  • Shimabukuro-Vornhagen A, García-Márquez M, Fischer RN, Iltgen-Breburda J, Fiedler A, Wennhold K, Rappl G, Abken H, Lehmann C, Herling M, Wolf D, Fätkenheuer G, Rubbert-Roth A, Hallek M, Theurich S, von Bergwelt-Baildon M (2016). Antigen-presenting human B cells are expanded in inflammatory conditions. J Leukoc Biol. 2016 Aug 17. pii: jlb.5A0416-182R. Epub 2016 Aug 17
  • Spinner S, Crispatzu G, Yi JH, Munkhbaatar E, Mayer P, Höckendorf U, Müller N, Li Z, Schader T, Bendz H, Hartmann S, Yabal M, Pechloff K, Heikenwalder M, Kelly GL, Strasser A, Peschel C, Hansmann ML, Ruland J, Keller U, Newrzela S, Herling M, Jost PJ (2016). Re-activation of mitochondrial apoptosis inhibits T cell lymphoma survival and treatment resistance. Leukemia. 2016 Jul;30(7):1520-30
  • Stiefelhagen M, Gigel C, Vasyutina E, Möllmann M, Breuer A, Mayer P, Dürig J, Herling M (2016). Activity of the CD40 antagonistic antibody lucatumumab - insights from CLL-niche mimicking xenografts and fludarabine combinations. Leuk Lymphoma. 2016 Jan 12:1-4

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Thorsten Hoppe

  • Ackermann L, Schell M, Pokrzywa W, Kevei E, Gartner A, Schumacher B, Hoppe T (2016).E4 ligase specific ubiquitylation hubs coordinate DNA double strand break repair and apoptosis. Nat Struct Mol Biol. 23, 995-1002
  • Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Ramadan K, Hoppe T (2016). Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun.7: 10612
  • Franz A, Ackermann L, Hoppe T (2016). Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Front Genet. 3; 7:73
  • Klionsky DJ, et al., (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12, 1-222
  • Liebl MP, Hoppe T (2016). It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin. Am J Physiol Cell Physiol. 311(2):C166-78

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Sandra Iden 

  • Ali NJ, Dias Gomes M, Bauer R, Brodesser S, Niemann C, Iden S (2016). Essential role of polarity protein Par3 for epidermal homeostasis through regulation of barrier function, keratinocyte differentiation and stem cell maintenance. J Invest Dermatol. 2016 Dec;136(12):2406-2416. doi: 10.1016/j.jid.2016.07.011. Epub 2016 Jul 21
  • Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA (2016). mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 2016 Oct 27;7:13226. doi: 10.1038/ncomms13226
  • Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D (2016). Epithelial barriers in murine skin during Herpes simplex virus 1 infection: the role of tight junction formation. J Invest Dermatol. Dec 6. pii: S0022-202X(16)32775-0. doi: 10.1016/j.jid.2016.11.027

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Hamid Kashkar

  • Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H, Ramadan K, Hoppe T (2016). Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 7:10612
  • Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L, Consortium IM, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC (2016). B cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B cell lymphoma in mice. Blood. 127(22):2732-41

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Peter Kloppenburg

  • Bradler C, Warren B, Bardos V, Schleicher S, Klein A, Kloppenburg P (2016). Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons. J Neurophysiol. 2016 May 1;115(5):2330-40. doi: 10.1152/jn.00840.2015
  • Hausen AC, Ruud J, Jiang H, Hess S, Varbanov H, Kloppenburg P, Brüning JC (2016). Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity. Cell Rep. 2016 Dec 6;17(10):2512-2521. doi: 10.1016/j.celrep.2016.11.030
  • Kumar A, Paeger L, Kosmas K, Kloppenburg P, Noegel AA, Peche VS (2016). Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2. Front Cell Neurosci. 2016 Jul 26;10:180. doi: 10.3389/fncel.2016.00180
  • Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC (2016). AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell. 2016 Mar 24;165(1):125-38. doi: 10.1016/j.cell.2016.02.044

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Jan-Wilhelm Kornfeld

  • Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R (2016). Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.Cell Rep. 2016 Oct 18;17(4):1008-1021. doi: 10.1016/j.celrep.2016.09.053
  • Oliverio M, Schmidt E, Mauer J, Baitzel C, Hansmeier NR, Khani S, Konieczka, Pradas-Juni M, Brodesser S, Van T, Bartsch DM, Brönneke HS, Heine M, Hilpert H, Tarcitano E, Garinis GA, Frommolt P, Heeren J, Mori MA, Brüning  JC, Kornfeld JW (2016). Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.Nat Cell Biol. 2016 Mar;18(3):328-36. doi: 10.1038/ncb3316
  • Schmidt E, Kornfeld JW (2016). Decoding Lamarck-transgenerational control of metabolism by noncoding RNAs. Pflugers Arch. 2016 Jun;468(6):959-69. doi: 10.1007/s00424-016-1807-8

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Thomas Krieg

  • Allanore Y, Denton CP, Krieg T, Cornelisse P, Rosenberg D, Schwierin B, Matucci-Cerinic M, DUO Investigators (2016). Clinical characteristics and predictors of gangrene in patients with systemic sclerosis and digital ulcers in the Digital Ulcer Outcome Registry: a prospective, observational cohort. Ann Rheum Dis. 75, 1736-1740
  • Fleger-Weckmann A, Ostun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R (2016). Deletion of the epidermis derived laminin ϒ1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol. May 25. pii: S0945-053X(16)30082-8. doi: 10.1016/j.matbio.2016.05.002. Epub 2016 May 25
  • Ghatak S, Niland S, Schulz JN, Wang F, Eble JA, Leitges M, Mauch C, Krieg T, Zigrino P, Eckes B (2016). Role of integrins α1β1 and α2β1 in wound and tumor angiogenesis in mice. Am J Pathol. 2016, 2016 Nov;186(11):3011-3027. doi: 10.1016/j.ajpath.2016.06.021. Epub 2016 Sep 14
  • Hunzelmann N, Riemekasten G, Becker MO, Moinzadeh P, Kreuter A, Melchers I, Mueller-Ladner U, Meier F, Worm M, Lee H, Herrgott I, Pfeiffer C, Fierlbeck G, Henes J, Juche A, Zeidler G, Mensing H, Gunther C, Sardy M, Burkhardt H, Koehm M, Kuhr K, Krieg T, Sunderkotter C (2016). The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase-1 antibodies. Br J Dermatol. Jun;174(6):1384-7
  • Khanna D, Denton CP, Merkel PA, Krieg T, LeBrun FO, MarrA, Papadakis K, Pope J, Matucci-Cerinic M, Furst DE; DUAL-1 Investigators; DUAL-2 Investigators (2016). Effect of macitentan on the development of new ischemic digital ulcers in patients with systemic sclerosis: DUAL-1 and DUAL-2 randomized clinical trials. J Am Med Assoc. 315, 1975-1988
  • Kreuter A, Krieg T, Worm M, Wenzel J, Moinzadeh P, Kuhn A, Aberer E, Scharffetter-Kochanek K, Horneff G, Reil E, Weberschock T, Hunzelmann N (2016). German guidelines for the diagnosis and therapy of localized scleroderma. J Dtsch Dermatol Ges. 14, 199-216
  • Moinzadeh P, Riemekasten G, Siegert E, Fierlbeck G, Henes J, Blank N, Melchers I, Mueller-Ladner U, Frerix M, Kreuter A, Tigges C, Lahner N, Susok L, Guenther C, Zeidler G, Pfeiffer C, Worm M, Karrer S, Aberer E, Bretterklieber A, Genth E, Simon JC, Distler JH, Hein R, Schneider M, Seitz CS, Herink C, Steinbrink K, Sardy M, Varga R, Mensing H, Mensing C, Lehmann P, Neeck G, Fiehn C, Weber M, Goebeler M, Burkhardt H, Buslau M, Ahmadi-Simab K, Himsel A, Juche A, Koetter I, Kuhn A, Sticherling M, Hellmich M, Kuhr K, Krieg T, Ehrchen J, Sunderkoetter C, Hunzelmann N (2016). German Network for Systemic Scleroderma. Vasoactive therapy in systemic sclerosis: real-life therapeutic practice in more than 3000 patients. J Rheumatol. 43, 66-74
  • Schulz JN, Nuchel J, Niehoff A, Bloch W, Schonborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B (2016). COMP-assisted collagen secretion--a novel intracellular function required for fibrosis. J Cell Sci. 129, 706-716
  • Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L (2016). Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol. May 24. pii: S0945-053X(16)30081-6. doi: 10.1016/j.matbio.2016.05.001 Epub 2016 May 24

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Martin Krönke

  • Meijles DN, Fan LM, Ghazaly MM, Howlin B, Krönke M, Brooks G, Li JM (2016). p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels. Circulation. 2391-403 

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Marcus Krüger

  • Ali T, Krüger M, Bhuju S, Jarek M, Bartkuhn M, Renkawitz R (2016). Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190. Nucleic Acids Res. 2016 Nov 29. pii: gkw1178. [Epub ahead of print] PubMed PMID: 27903907
  • Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP (2016). The Failing Heart Relies on Ketone Bodies as a Fuel. Circulation. 23;133 (8):698-705
  • Boeckel JN, Derlet A, Glaser SF, Luczak A, Lucas T, Heumüller AW, Krüger M, Zehendner CM, Kaluza D, Doddaballapur A, Ohtani K, Treguer K, Dimmeler S (2016). JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells. Arterioscler Thromb Vasc Biol. May 19
  • Gerl MJ, Bittl V, Kirchner S, Sachsenheimer T, Brunner HL, Lüchtenborg C, Özbalci C, Wiedemann H, Wegehingel S, Nickel W, Haberkant P, Schultz C, Krüger M, Brügger B (2016). Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLoS One. 21;11(4)
  • Horn S, Kirkegaard JS, Hoelper S, Seymour PA, Rescan C, Nielsen JH, Madsen OD, Jensen JN, Krüger M, Grønborg M, Ahnfelt-Rønne J (2016). Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo. Mol Endocrinol. 2016 Jan;30(1):133-43. doi: 10.1210/me.2015-1208. Epub 2015 Dec 9
  • Housley MP, Njaine B, Ricciardi F, Stone OA, Hölper S, Krüger M, Kostin S, Stainier DY (2016). Cavin4b/Murcb Is Required for Skeletal Muscle Development and Function in Zebrafish. PLoS Genet. Jun 13;12(6):e1006099
  • Islam S, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M (2016). Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum Mol Genet. 2016 Oct 29
  • Marabita M, Baraldo M, Solagna F, Ceelen J, Sartori R, Nolte H, Nemazanyy I, Pyronnet S, Krüger M, Pende M, Blaauw B (2016). S6K1 is required for increasing skeletal muscle force during Hypertrophy. Cell Reports
  • Martire A, Bedada FB, Uchida S, Pöling J, Krüger M, Warnecke H, Richter M, Kubin T, Herold S, Braun T (2016). Mesenchymal stem cells attenuate inflammatory processes in the heart and lung via inhibition of TNF signaling. Basic Res Cardiol. 2016 Sep;111(5):54
  • Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Martinez IS, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T (2016). The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet. 2016 Jan 19
  • Rodriguez-Gil A, Ritter O, Hornung J, Stekman H, Krüger M, Braun T, Kremmer E, Kracht M, Schmitz ML (2016). HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell. pii: mbc.E15-09-0629
  • Shin J, Watanabe S, Hoelper S, Krüger M, Kostin S, Pöling J, Kubin T, Braun T (2016). BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. Elife. 2016 Dec 1;5. pii: e18351. doi: 10.7554/eLife.18351. PubMed PMID: 27906130; PubMed Central PMCID: PMC5148607
  • Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016). CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J. 2016 Oct 20
  • Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T (2016). The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 2016 Oct 13

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Leo Kurian

  • Frank S, Aguirre A, Hescheler J, Kurian L (2016). A lncRNA Perspective into (Re)Building the Heart. Front Cell Dev Biol. 2016 Nov 9;4:128. PMID: 27882316

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Michael Lammers

  • Bhattacharya K, Swaminathan K, Clemen C, Peche V, Knyphausen P, Lammers M, Noegel A, Rastetter R (2016). Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology. Scientific Reports. 6: 25411
  • Knyphausen P, de Boor S, Scislowski L, Extra A, Baldus L, Kuhlmann N, Schacherl M, Baumann U, Neundorf I, Lammers M (2016). Mechanistic insights into lysine-deacetylation of natively folded substrate proteins by sirtuins. J Biol Chem. 291, 14677-14694
  • Knyphausen P, Lang F, Baldus L, Extra A, Lammers M (2016). Insights into K-Ras 4B regulation by post-translational lysine acetylation. Biological Chemistry. 397: 1071-1085
  • Kuhlmann N, Wroblowski S, Scislowski L, Lammers M (2016). RhoGDIa acetylation at K127 and K141 affects binding toward nonprenylated RhoA. Biochemistry. 2, 304-312
  • Kuhlmann N, Wroblowski S, Knyphausen P, de Boor S, Brenig J, Baldus L, Scislowski L, Meyer-Teschendorf K, Zienert AY, Praefcke GJK, Nolte H, Krüger M, Schacherl M, Baumann U,  James LC, Chin JW, Lammers M (2016).Structural and mechanistic insights into the regulation of the Rho-regulator RhoGDIa by lysine acetylation. J Biol Chem. 291, 5484-5499

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Thomas Langer

  • Aaltonen MJ, Friedman JR, Osman C, Salin B, di Rago JP, Nunnari J, Langer T, Tatsuta T (2016). MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria. J Cell Biol. 213, 525-534. doi: 10.1083/jcb.201602007
  • Hartmann B, Wai T, Hu H, MacVicar T, Musante L, Fischer-Zirnsak B, Stenzel W, Gräf R, van den Heuvel L, Ropers HH, Wienker TF, Hübner C, Langer T, Kaindl AM (2016). Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation. eLife. 5. doi: 10.7554/eLife.16078
  • König T, Tröder SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, Mühlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, Langer T (2016). The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria. Mol Cell. 64, 148-162. doi: 10.1016/j.molcel.2016.08.020
  • Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quiros PM, López-Otín C, Rugarli EI, Langer T (2016). Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 212, 157-166. doi: 10.1083/jcb.201507022
  • MacVicar T, Langer T (2016). OPA1 processing in cell death and disease: the long and short of it. J Cell Sci. 129, 2297-2306. doi:10.1242/jcs.159186
  • Mandel H, Saita S, Edvardson S, Jalas C, Shaag A, Goldsher D, Vlodavsky E, Langer T, Elpeleg O (2016). Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria. J Med Genet. 0, 1-7. doi: 10.1136/jmedgenet-2016-103922
  • Wai T, Langer T (2016). Mitochondrial dynamics and metabolic regulation. Trends Endocrinol Metab. 2, 105-117. doi: 10.1016/j.tem.2015.12.001
  • Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T (2016). The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 17, 1844-1856. doi: 10.15252/embr.201642698
  • Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen C, Rugarli EI (2016). The mitochondrial m-AAA protease prevents demyelination and hair greying. PLOS Genet. 12, e1006463. doi: 10.1371/journal.pgen.1006463

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Nils-Göran Larsson

  • Gustafsson CM, Falkenberg M, Larsson NG (2016). Maintenance and expression of mammalian mtDNA. Annu Rev Biochem. 2016 Jun 2;85:133-60
  • Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB (2016). A phenotype-driven approach to generate mouse models with pathogenic mtDNA mutations causing mitochondrial disease. Cell Rep. 2016 Sep 13;16(11):2980-90
  • Kühl I, Miranda M, Posse V, Milenkovic D, Mourier A, Siira S, Bonekamp NA, Neumann U, Filipovska A, Loguercio Polosa P, Gustafsson CM, Larsson NG (2016). POLRMT regulates the switch between replication-primer formation and gene expression of mammalian mtDNA.Science Adv. 2016 Aug 05. e1600963
  • Oliver Rackham O, Busch JD, Matic S, Siira S, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AMJ, Richman TR, Stewart J, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016). Hierarchical RNA processing is required for mitochondrial ribosomeassembly.Cell Reports. 2016 Aug 16;16(7):1874-90
  • Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, Mourier A, Bratic A, García-Bartolomé A, Fernández-Vizarra E, Cadenas S, Delmiro A, García-Consuegra I, Arenas J, Martín MA, Larsson NG, Ugalde C (2016). COX7A2L preferentially interacts with mitochondrial complex III to stabilize the III2+IV supercomplex without affecting respirasome formation.Cell Rep. 2016 Aug 30;16(9):2387-98
  • RichmanTA, Spåhr H, Ermer JA, Davies SMK., Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A (2016). Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nature Comm. 2016:7:11884. doi: 10.1038/ncomms11884
  • Silva Ramos E, Larsson NG, Mourier A (2016). Bioenergetic role of mitochondrial fusion. Biochem Biophys Acta. 2016:1857(8):1277-1283
  • Spåhr H, Rozanska A, Li X, Atanassov I,Lightowlers RN, Chrzanowska-Lightowlers ZMA, Rackham O, Larsson NG(2016). SLIRP stabilizes LRPPRC via an RRM-PPR protein interface.Nucl Acids Res. 2016 Aug 19;44(14):6868-82

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Ivan Matic

  • Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I (2016). Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination, Impairs Conventional Ubiquitination. Cell. 167, 6, 1636-1649 e13
  • Leidecker O, Bonfiglio JJ, Colby T, Zhang Q, Atanassov I, Zaja R, Palazzo L, Stockum A, Ahel I, Matic I (2016). Serine is a new target residue for endogenous ADP-ribosylation on histones. Nat Chem Biol. 12, 12, 998-1000

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Roman-Ulrich Müller

  • Bartram MP, Amendola E, Benzing T, Schermer B, de Vita G, Müller RU (2016).Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure. BMC Mol Biol. May 2016
  • Braun F, Rinschen MM, Bartels V, Frommolt P, Habermann B, Hoeijmakers JHJ, Schumacher B, Dollé MET, Müller RU, Benzing T, Schermer B, Kurschat CE (2016). Altered lipid metabolism in the aging kidney identified by three layered omic analysis. Aging. (Albany NY), Jan 2016
  • Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT (2016). Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier. Am J Pathol. May 2016
  • Johnsen M, Späth MR, Denzel MS, Göbel H, Kubacki T, Hoyer KJR, Hinze Y, Benzing T, Schermer B, Antebi A, Burst V, Müller RU (2016). Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage. PLoS ONE. Aug 2016
  • Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Martinez IS, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T (2016). The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet. Jan 2016
  • Völker L, Johnsen M, Burst V, Müller RU (2016). Hypoxia signaling and renal failure – a double-edged sword. Nieren- und Hochdruckkrankheiten. Mar 2016

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Carien Niessen

  • Green KJ, Niessen CM (2016). Degrees of Freedom: Your Future in Biomedical Research. J Invest Dermatol. 136:1073-1076
  • Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT (2016). Par3A is dispensable for the function of the glomerular filtration barrier of the kidney. Am J Physiol Renal Physiol. Apr 27:ajprenal.00171.2016. doi: 10.1152/ajprenal.00171.2016. Epub 2016 Apr 27
  • Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA (2016). Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol. 2016 Aug;18(8):864-75. doi: 10.1038/ncb3387
  • Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D (2016). Epithelial barriers in murine skin during herpes simplex virus 1 infection: The role of tight junction formation. J Invest Dermatol. 2016 Dec 6. pii: S0022-202X(16)32775-0. doi: 10.1016/j.jid.2016.11.027. Epub 2016 Dec 6
  • Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M (2016). Growth retardation, loss of desmosomal adhesion and impaired tight junction function identify a unique role of plakophilin in vivo. J Invest Derm. Mar 28. pii: S0022-202X(16)30984-8. doi: 10.1016/j.jid.2016.03.021. Epub 2016 Mar 28
  • Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli EI (2016). The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying. PLoS Genet. 2016 Dec 2;12(12):e1006463. doi: 10.1371/journal.pgen.1006463

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Angelika Noegel

  • Behrens J, Ziemann A, Solga R, Rastetter RH, Berwanger C, Herrmann H, Noegel AA, Clemen CS (2016). Knock-out of CRN2 (coronin 1C) causes multiple cytoskeletal alterations and mitochondrial dysfunction. Eur J Cell Biol. 95, 239-251
  • Bhattacharya K, Swaminathan K, Clemen CS, Peche V, Knyphausen P, Lammers M, Noegel AA, Rastetter RH (2016). Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology. Scientific Reports. 6, 25411
  • Burgute BD, Peche VS, Müller R, Matthias J, Gaßen B, Eichinger L, Glöckner G, Noegel AA (2016). The C-terminal SynMuv/DdDUF 926 domain regulates the function of the N-terminal domain of DdNKAP. PLoS ONE. 11:e0168617
  • Klionsky DJ, et al. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy. (3rd edition). Autophagy. 12, 1-122
  • Kumar A, Paeger L, Kosmas K, Kloppenburg P, Noegel AA, Peche VS (2016). Neuronal actin dynamics, spine density and neuronal dendritic complexity are regulated by CAP2. Frontiers in Cellular Neuroscience. 10, 180
  • Schilde C, Lawal H, Noegel AA, Eichinger L, Schaap P, Glöckner G (2016). A set of genes conserved in sequence and expression traces back the establishment of multicellularity in social amoebae. BMC Genomics. 17, 871
  • Stöckigt F, Peche VS, Linhart M, Nickenig G, Noegel AA, Schrickel JW (2016). Deficiency of cyclase-associated protein 2 promotes arrhythmias associated with connexin43 maldistribution and fibrosis. Arch Med Sci. 12, 188-198
  • Szczepanski S, Hussain MS, Sur I, Altmüller J, Thiele H, Abdullah U, Waseem SS, Moawia A, Nürnberg G, Noegel AA, Baig SM, Nürnberg P (2016). A novel homozygous splicing mutation of CASC5 causes primary microcephaly in a large Pakistani family. Hum Genet. 135, 157-170

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Peter Nürnberg

  • Acuna M, Martinez P, Moraga C, He X, Moraga M, Hunter B, Nürnberg P, Gutierrez RA, Gonzalez M, Schuchman EH, Santos JL, Miquel JF, Mabe P, Zanlungo S (2016). Epidemiological, clinical and biochemical characterization of the p.(Ala359Asp) SMPD1 variant causing Niemann-Pick disease type B. Eur J Hum Genet. 24, 208-213
  • Ahmad I, Baig SM, Abdulkareem AR, Hussain MS, Sur I, Toliat MR, Nurnberg G, Dalibor N, Moawia A, Waseem SS, Asif M, Nagra H, Sher M, Ali Khan MM, Hassan I, Ur Rehman S, Thiele H, Altmuller J, Noegel AA, Nürnberg P (2016). Genetic heterogeneity in Pakistani microcephaly families revisited. Clin Genet. doi:10.1111/cge.12955
  • Altmuller J, Motameny S, Becker C, Thiele H, Chatterjee S, Wollnik B, Nürnberg P (2016). A systematic comparison of two new releases of exome sequencing products: the aim of use determines the choice of product. Biological Chemistry. 397, 791-801
  • Ammann S, Schulz A, Krageloh-Mann I, Dieckmann NM, Niethammer K, Fuchs S, Eckl KM, Plank R, Werner R, Altmuller J, Thiele H, Nürnberg P, Bank J, Strauss A, von Bernuth H, Zur Stadt U, Grieve S, Griffiths GM, Lehmberg K, Hennies HC, Ehl S (2016). Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome. Blood. 127, 997-1006
  • Basmanav FB, Cau L, Tafazzoli A, Mechin MC, Wolf S, Romano MT, Valentin F, Wiegmann H, Huchenq A, Kandil R, Garcia Bartels N, Kilic A, George S, Ralser DJ, Bergner S, Ferguson DJ, Oprisoreanu AM, Wehner M, Thiele H, Altmuller J, Nürnberg P, Swan D, Houniet D, Buchner A, Weibel L, Wagner N, Grimalt R, Bygum A, Serre G, Blume-Peytavi U, Sprecher E, Schoch S, Oji V, Hamm H, Farrant P, Simon M, Betz RC (2016). Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome. Am J Hum Genet. 99, 1292-1304
  • Becker K, Siegert S, Toliat MR, Du J, Casper R, Dolmans GH, Werker PM, Tinschert S, Franke A, Gieger C, Strauch K, Nothnagel M, Nürnberg P, Hennies HC (2016). Meta-Analysis of Genome-Wide Association Studies and Network Analysis-Based Integration with Gene Expression Data Identify New Suggestive Loci and Unravel a Wnt-Centric Network Associated with Dupuytren's Disease. PLoS ONE. 11, e0158101
  • Bey K, Lennertz L, Markett S, Petrovsky N, Gallinat J, Grunder G, Spreckelmeyer KN, Wienker TF, Mobascher A, Dahmen N, Thuerauf N, Kornhuber J, Kiefer F, Toliat MR, Nürnberg P, Winterer G, Wagner M (2016). Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample. Eur Neuropsychopharm. 26, 150-155
  • Bogershausen N, Altunoglu U, Beleggia F, Yigit G, Kayserili H, Nürnberg P, Li Y, Altmuller J, Wollnik B (2016). An Unusual Presentation of Kabuki Syndrome with Orbital Cysts, Microphthalmia, and Cholestasis with Bile Duct Paucity. Am J Med GenetPart A. 170, 3282-3288
  • Bogershausen N, Gatinois V, Riehmer V, Kayserili H, Becker J, Thoenes M, Simsek-Kiper PO, Barat-Houari M, Elcioglu NH, Wieczorek D, Tinschert S, Sarrabay G, Strom TM, Fabre A, Baynam G, Sanchez E, Nurnberg G, Altunoglu U, Capri Y, Isidor B, Lacombe D, Corsini C, Cormier-Daire V, Sanlaville D, Giuliano F, Le Quan Sang KH, Kayirangwa H, Nürnberg P, Meitinger T, Boduroglu K, Zoll B, Lyonnet S, Tzschach A, Verloes A, Di Donato N, Touitou I, Netzer C, Li Y, Genevieve D, Yigit G, Wollnik B (2016). Mutation Update for Kabuki Syndrome Genes KMT2D and KDM6A and Further Delineation of X-Linked Kabuki Syndrome Subtype 2. Human Mutation. 37, 847-864
  • Claushuis TA, van Vught LA, Scicluna BP, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Ong DS, Cremer OL, Horn J, Franitza M, Toliat MR, Nürnberg P, Zwinderman AH, Bonten MJ, Schultz MJ, van der Poll T (2016). Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood. 127, 3062-3072
  • Daud S, Kakar N, Goebel I, Hashmi AS, Yaqub T, Nurnberg G, Nürnberg P, Morris-Rosendahl DJ, Wasim M, Volk AE, Kubisch C, Ahmad J, Borck G (2016). Identification of two novel ALS2 mutations in infantile-onset ascending hereditary spastic paraplegia. Amyotroph Lat Scl Fr.17, 260-265
  • Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, Melo FDSE, Prasetyanti PR, Ijspeert JEG, Franitza M, Nürnberg P, van Noesel CJM, Dekker E, Vermeulen L, Clevers H, Medema JP (2016). TGF beta signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Molecular Medicine. 8, 745-760
  • Gardella E, Becker F, Moller RS, Schubert J, Lemke JR, Larsen LH, Eiberg H, Nothnagel M, Thiele H, Altmuller J, Syrbe S, Merkenschlager A, Bast T, Steinhoff B, Nürnberg P, Mang Y, Bakke Moller L, Gellert P, Heron SE, Dibbens LM, Weckhuysen S, Dahl HA, Biskup S, Tommerup N, Hjalgrim H, Lerche H, Beniczky S, Weber YG (2016). Benign infantile seizures and paroxysmal dyskinesia caused by an SCN8A mutation. Ann Neurol. 79, 428-436
  • Gardella E, Beniczky S, Moller RS, Becker F, Lemke JR, Syrbe S, Eiberg H, Bast T, Steinhoff B, Nürnberg P, Gellert P, Dahl HA, Weckhuysen S, Heron SE, Dibbens LM, Hjalgrim H, Lerche H, Weber YG (2016). PKD or Not PKD: That Is the Question Reply. Annals of Neurology. 80, 168-169
  • Geisel MH, Coassin S, Hessler N, Bauer M, Eisele L, Erbel R, Haun M, Hennig F, Moskau-Hartmann S, Hoffmann B, Jockel KH, Kedenko L, Kiechl S, Kollerits B, Mahabadi AA, Moebus S, Nurnberg G, Nürnberg P, Paulweber B, Vens M, Willeit J, Willeit K, Klockgether T, Ziegler A, Scherag A, Kronenberg F (2016). Update of the effect estimates for common variants associated with carotid intima media thickness within four independent samples: The Bonn IMT Family Study, the Heinz Nixdorf Recall Study, the SAPHIR Study and the Bruneck Study. Atherosclerosis. 249, 83-87
  • Gruber R, Rainer G, Weiss A, Udvardi A, Thiele H, Eckl KM, Schupart R, Nürnberg P, Zschocke J, Schmuth M, Volc-Platzer B, Hennies HC (2016). Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations. Br J Dermatol. doi: 10.1111/bjd.14860
  • Haliloglu G, Becker K, Temucin C, Talim B, Kucuksahin N, Pergande M, Motameny S, Nürnberg P, Aydingoz U, Topaloglu H, Cirak S (2016). Recessive PIEZO2 stop mutation causes distal arthrogryposis with distal muscle weakness, scoliosis and proprioception defects. J Hum Genet. doi: 10.1038/jhg.2016.153
  • Hallmann K, Kudin AP, Zsurka G, Kornblum C, Reimann J, Stuve B, Waltz S, Hattingen E, Thiele H, Nürnberg P, Rub C, Voos W, Kopatz J, Neumann H, Kunz WS (2016). Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy. Brain. 139, 338-345
  • Harley ME, Murina O, Leitch A, Higgs MR, Bicknell LS, Yigit G, Blackford AN, Zlatanou A, Mackenzie KJ, Reddy K, Halachev M, McGlasson S, Reijns MA, Fluteau A, Martin CA, Sabbioneda S, Elcioglu NH, Altmuller J, Thiele H, Greenhalgh L, Chessa L, Maghnie M, Salim M, Bober MB, Nürnberg P, Jackson SP, Hurles ME, Wollnik B, Stewart GS, Jackson AP (2016). TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet. 48, 36-43
  • Hatzold J, Beleggia F, Herzig H, Altmuller J, Nürnberg P, Bloch W, Wollnik B, Hammerschmidt M (2016). Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. eLife. 5
  • Heimbach A, Hauke J, Richters L, Krober S, Altmuller J, Becker C, Thiele H, Nürnberg P, Blumcke B, Neidhardt G, Riehm K, Schmutzler R, Hahnen E (2016). TruRisk (R) based next-generation sequencing reveals a high prevalence of deleterious ATM mutations in BRCA1/2-negative breast and ovarian cancer families. Oncol Res Treat. 39, 52-52
  • Herling CD, Klaumunzer M, Rocha CK, Altmuller J, Thiele H, Bahlo J, Kluth S, Crispatzu G, Herling M, Schiller J, Engelke A, Tausch E, Dohner H, Fischer K, Goede V, Nürnberg P, Reinhardt HC, Stilgenbauer S, Hallek M, Kreuzer KA (2016). Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy. Blood. 128, 395-404
  • Hessler N, Geisel MH, Coassin S, Erbel R, Heilmann S, Hennig F, Hoffmann B, Jockel KH, Moebus S, Moskau-Hartmann S, Nurnberg G, Nürnberg P, Vens M, Klockgether T, Kronenberg F, Scherag A, Ziegler A (2016). Linkage and Association Analysis Identifies TRAF1 Influencing Common Carotid Intima-Media Thickness. Stroke. 47, 2904-2909
  • Huson MA, Scicluna BP, van Vught LA, Wiewel MA, Hoogendijk AJ, Cremer OL, Bonten MJ, Schultz MJ, Franitza M, Toliat MR, Nürnberg P, Grobusch MP, van der Poll T (2016). The Impact of HIV Co-Infection on the Genomic Response to Sepsis. PLoS ONE. 11, e0148955
  • Ikram F, Ackermann S, Kahlert Y, Volland R, Roels F, Engesser A, Hertwig F, Kocak H, Hero B, Dreidax D, Henrich KO, Berthold F, Nürnberg P, Westermann F, Fischer M (2016). Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma. Molecular Oncology. 10, 344-359
  • Jabbari K, Nürnberg P (2016). A genomic view on epilepsy and autism candidate genes. Genomics. 108, 31-36
  • Karakaya M, Heller R, Kunde V, Zimmer KP, Chao CM, Nürnberg P, Cirak S (2016). Novel Mutations in the Nonselective Sodium Leak Channel (NALCN) Lead to Distal Arthrogryposis with Increased Muscle Tone. Neuropediatrics. 47, 273-277
  • Korenke GC, Eggert M, Thiele H, Nürnberg P, Sander T, Steinlein OK (2016). Nocturnal frontal lobe epilepsy caused by a mutation in the GATOR1 complex gene NPRL3. Epilepsia. 57, E60-E63
  • Kropatsch R, Akkad DA, Frank M, Rosenhagen C, Altmuller J, Nürnberg P, Epplen JT, Dekomien G (2016). A large deletion in RPGR causes XLPRA in Weimaraner dogs. Canine Genetics and Epidemiology. 3, 7
  • Laghmani K, Beck BB, Yang SS, Seaayfan E, Wenzel A, Reusch B, Vitzthum H, Priem D, Demaretz S, Bergmann K, Duin LK, Gobel H, Mache C, Thiele H, Bartram MP, Dombret C, Altmuller J, Nürnberg P, Benzing T, Levtchenko E, Seyberth HW, Klaus G, Yigit G, Lin SH, Timmer A, de Koning TJ, Scherjon SA, Schlingmann KP, Bertrand MJM, Rinschen MM, de Backer O, Konrad M, Komhoff M (2016). Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. New Engl J Med. 374, 1853-1863
  • Lal D, Neubauer BA, Toliat MR, Altmuller J, Thiele H, Nürnberg P, Kamrath C, Schanzer A, Sander T, Hahn A, Nothnagel M (2016). Increased Probability of Co-Occurrence of Two Rare Diseases in Consanguineous Families and Resolution of a Complex Phenotype by Next Generation Sequencing. PLoS ONE. 11, e0146040
  • Lal D, Reinthaler EM, Dejanovic B, May P, Thiele H, Lehesjoki AE, Schwarz G, Riesch E, Ikram MA, van Duijn CM, Uitterlinden AG, Hofman A, Steinbock H, Gruber-Sedlmayr U, Neophytou B, Zara F, Hahn A, Gormley P, Becker F, Weber YG, Cilio MR, Kunz WS, Krause R, Zimprich F, Lemke JR, Nürnberg P, Sander T, Lerche H, Neubauer BA (2016). Evaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes. PLoS ONE. 11, e0150426
  • Lemke JR, Geider K, Helbig KL, Heyne HO, Schutz H, Hentschel J, Courage C, Depienne C, Nava C, Heron D, Moller RS, Hjalgrim H, Lal D, Neubauer BA, Nürnberg P, Thiele H, Kurlemann G, Arnold GL, Bhambhani V, Bartholdi D, Pedurupillay CR, Misceo D, Frengen E, Stromme P, Dlugos DJ, Doherty ES, Bijlsma EK, Ruivenkamp CA, Hoffer MJ, Goldstein A, Rajan DS, Narayanan V, Ramsey K, Belnap N, Schrauwen I, Richholt R, Koeleman BP, Sa J, Mendonca C, de Kovel CG, Weckhuysen S, Hardies K, De Jonghe P, De Meirleir L, Milh M, Badens C, Lebrun M, Busa T, Francannet C, Piton A, Riesch E, Biskup S, Vogt H, Dorn T, Helbig I, Michaud JL, Laube B, Syrbe S (2016). Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy. Neurology. 86, 2171-2178
  • Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C, Gorski M, Lyytikainen LP, Nutile T, Sedaghat S, Sorice R, Tin A, Yang Q, Ahluwalia TS, Arking DE, Bihlmeyer NA, Boger CA, Carroll RJ, Chasman DI, Cornelis MC, Dehghan A, Faul JD, Feitosa MF, Gambaro G, Gasparini P, Giulianini F, Heid I, Huang J, Imboden M, Jackson AU, Jeff J, Jhun MA, Katz R, Kifley A, Kilpelainen TO, Kumar A, Laakso M, Li-Gao R, Lohman K, Lu Y, Magi R, Malerba G, Mihailov E, Mohlke KL, Mook-Kanamori DO, Robino A, Ruderfer D, Salvi E, Schick UM, Schulz CA, Smith AV, Smith JA, Traglia M, Yerges-Armstrong LM, Zhao W, Goodarzi MO, Kraja AT, Liu C, Wessel J, Boerwinkle E, Borecki IB, Bork-Jensen J, Bottinger EP, Braga D, Brandslund I, Brody JA, Campbell A, Carey DJ, Christensen C, Coresh J, Crook E, Curhan GC, Cusi D, de Boer IH, de Vries AP, Denny JC, Devuyst O, Dreisbach AW, Endlich K, Esko T, Franco OH, Fulop T, Gerhard GS, Glumer C, Gottesman O, Grarup N, Gudnason V, Harris TB, Hayward C, Hocking L, Hofman A, Hu FB, Husemoen LL, Jackson RD, Jorgensen T, Jorgensen ME, Kahonen M, Kardia SL, Konig W, Kooperberg C, Kriebel J, Launer LJ, Lauritzen T, Lehtimaki T, Levy D, Linksted P, Linneberg A, Liu Y, Loos RJ, Lupo A, Meisinger C, Melander O, Metspalu A, Mitchell P, Nauck M, Nürnberg P, Orho-Melander M, Parsa A, Pedersen O, Peters A, Peters U, Polasek O, Porteous D, Probst-Hensch NM, Psaty BM, Qi L, Raitakari OT, Reiner AP, Rettig R, Ridker PM, Rivadeneira F, Rossouw JE, Schmidt F, Siscovick D, Soranzo N, Strauch K, Toniolo D, Turner ST, Uitterlinden AG, Ulivi S, Velayutham D, Volker U, Volzke H, Waldenberger M, Wang JJ, Weir DR, Witte D, Kuivaniemi H, Fox CS, Franceschini N, Goessling W, Kottgen A, Chu AY (2016). SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. Doi: 10.1681/ASN.2016020131
  • Mobascher A, Diaz-Lacava A, Wagner M, Gallinat J, Wienker TF, Drichel D, Becker T, Steffens M, Dahmen N, Grunder G, Thurauf N, Kiefer F, Kornhuber J, Toliat MR, Thiele H, Nürnberg P, Steinlein O, Winterer G (2016). Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large Population-Based Sample. PLoS ONE. 11. e0152984
  • Moinzadeh P, Frommolt P, Franitza M, Toliat MR, Becker K, Nürnberg P, Nihtyanova SI, Ahrazoglu M, Belz D, Hunzelmann N, Abraham D, Ong VH, Mouthon L, Hesselstrand R, Denton CP, Krieg T (2016). Identification of an expression-based set of genes to predict the subset of patients with systemic scleroderma (SSc). Experimental Dermatology. 25, 10-10
  • Moosa S, Chung BHY, Tung JYL, Altmuller J, Thiele H, Nürnberg P, Netzer C, Nishimura G, Wollnik B (2016). Mutations in SEC24D cause autosomal recessive osteogenesis imperfecta. Clinical Genetics. 89, 517-519
  • Moosa S, Fano V, Obregon MG, Altmuller J, Thiele H, Nürnberg P, Nishimura G, Wollnik B (2016). A Novel Homozygous PAM16 Mutation in a Patient with a Milder Phenotype and Longer Survival. Am J Med Genet A. 170, 2436-2439
  • Moosa S, Obregon MG, Altmuller J, Thiele H, Nürnberg P, Fano V, Wollnik B (2016). Novel IFT122 Mutations in Three Argentinian Patients with Cranioectodermal Dysplasia: Expanding the Mutational Spectrum. Am J Med Genet A. 170, 1295-1301
  • Murray JE, Bicknell LS, Yigit G, Duker AL, van Kogelenberg M, Haghayegh S, Wieczorek D, Kayserili H, Albert MH, Wise CA, Brandon J, Kleefstra T, Warris A, van der Flier M, Bamforth JS, Doonanco K, Ades L, Ma A, Field M, Johnson D, Shackley F, Firth H, Woods CG, Nürnberg P, Gatti RA, Hurles M, Bober MB, Wollnik B, Jackson AP (2016). Extreme Growth Failure is a Common Presentation of Ligase IV Deficiency (vol 35, pg 76, 2014). Human Mutation. 37, 983-983
  • Neidhardt G, Hauke J, Heilmann S, Hellebrand H, Surowy HM, Klaschik K, Honisch E, Gehrig A, Sutter C, Rump A, Bogdanova-Markov N, Bugert P, Mangold E, Steinemann D, Ramirez A, Ditsch N, Arnold N, Niederacher D, Burwinkel B, Thiele H, Altmuller I, Nürnberg P, Engel C, Wappenschmidt B, Rhiem K, Meindl A, Schmutzler RK, Hahnen E (2016). Compelling evidence for FANCM as a breast cancer susceptibility gene. Oncol Res Treat. 39, 54-54
  • Neidhardt G, Hauke J, Ramser J, Groß E, Gehrig A, Müller CR, Kahlert AK, Hackmann K, Honisch E, Niederacher D, Heilmann-Heimbach S, Franke A, Lieb W, Thiele H, Altmüller J,Nürnberg P, Klaschik K, Ernst C, Ditsch N, Jessen F, Ramirez A, Wappenschmidt B, Engel C, Rhiem K, Meindl A, Schmutzler RK, Hahnen E (2016). Association Between Loss-of-Function Mutations Within the FANCM Gene and Early-Onset Familial Breast Cancer. JAMA Oncology. doi: 10.1001/jamaoncol.2016.5592
  • Nieuwenhuis MA, Siedlinski M, van den Berge M, Granell R, Li X, Niens M, van der Vlies P, Altmuller J, Nürnberg P, Kerkhof M, van Schayck OC, Riemersma RA, van der Molen T, de Monchy JG, Bosse Y, Sandford A, Bruijnzeel-Koomen CA, Gerth van Wijk R, ten Hacken NH, Timens W, Boezen HM, Henderson J, Kabesch M, Vonk JM, Postma DS, Koppelman GH (2016). Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma. Allergy. 71, 1712-1720
  • Ortiz-Cuaran S, Scheffler M, Plenker D, Dahmen L, Scheel AH, Fernandez-Cuesta L, Meder L, Lovly CM, Persigehl T, Merkelbach-Bruse S, Bos M, Michels S, Fischer R, Albus K, Konig K, Schildhaus HU, Fassunke J, Ihle MA, Pasternack H, Heydt C, Becker C, Altmuller J, Ji H, Muller C, Florin A, Heuckmann JM, Nürnberg P, Ansen S, Heukamp LC, Berg J, Pao W, Peifer M, Buettner R, Wolf J, Thomas RK, Sos ML (2016). Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors. Clinical Cancer Research : an official journal of the American Association for Cancer Research. 22, 4837-4847
  • Rahner N, Nuernberg G, Finis D, Nürnberg P, Royer-Pokora B (2016). A novel C8orf37 splice mutation and genotype-phenotype correlation for cone-rod dystrophy. Ophthalmic Genetics. 37, 294-300
  • Reiff C, Owczarek-Lipska M, Spital G, Roger C, Hinz H, Juschke C, Thiele H, Altmuller J, Nürnberg P, Da Costa R, Neidhardt J (2016). The mutation p. E113K in the Schiff base counterion of rhodopsin is associated with two distinct retinal phenotypes within the same family. Scientific Reports. 6. Doi: 10.1038/Srep36208
  • Seifert W, Posor Y, Schu P, Stenbeck G, Mundlos S, Klaassen S, Nürnberg P, Haucke V, Kornak U, Kuhnisch J (2016). The progressive ankylosis protein ANK facilitates clathrin- and adaptor-mediated membrane traffic at the trans-Golgi network-to-endosome interface. Hum Mol Genet. 25, 3836-3848
  • Spielmann M, Kakar N, Tayebi N, Leettola C, Nurnberg G, Sowada N, Lupianez DG, Harabula I, Flottmann R, Horn D, Chan WL, Wittler L, Yilmaz R, Altmuller J, Thiele H, van Bokhoven H, Schwartz CE, Nürnberg P, Bowie JU, Ahmad J, Kubisch C, Mundlos S, Borck G (2016). Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. Genome Research. 26, 183-191
  • Sukumaran SK, Stumpf M, Salamon S, Ahmad I, Bhattacharya K, Fischer S, Muller R, Altmuller J, Budde B, Thiele H, Tariq M, Malik NA, Nürnberg P, Baig SM, Hussain MS, Noegel AA (2016). CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly. Molecular Genetics and Genomics. doi: 10.1007/s00438-016-1277-x
  • Szczepanski S, Hussain MS, Sur I, Altmuller J, Thiele H, Abdullah U, Waseem SS, Moawia A, Nurnberg G, Noegel AA, Baig SM, Nürnberg P (2016). A novel homozygous splicing mutation of CASC5 causes primary microcephaly in a large Pakistani family. Human Genetics. 135, 157-170
  • Tiwari A, Lemke J, Altmueller J, Thiele H, Glaus E, Fleischhauer J, Nürnberg P, Neidhardt J, Berger W (2016). Identification of Novel and Recurrent Disease-Causing Mutations in Retinal Dystrophies Using Whole Exome Sequencing (WES): Benefits and Limitations. PLoS ONE. 11. e0158692
  • van Vught LA, Klein Klouwenberg PM, Spitoni C, Scicluna BP, Wiewel MA, Horn J, Schultz MJ, Nürnberg P, Bonten MJ, Cremer OL, van der Poll T (2016). Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis. Jama. 315, 1469-1479
  • van Vught LA, Scicluna BP, Hoogendijk AJ, Wiewel MA, Klein Klouwenberg PM, Cremer OL, Horn J, Nürnberg P, Bonten MM, Schultz MJ, van der Poll T (2016). Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients. Crit Care. 20, 252
  • van Vught LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, Klein Klouwenberg PM, Franitza M, Toliat MR, Nürnberg P, Cremer OL, Horn J, Schultz MJ, Bonten MM, van der Poll T (2016). Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients. Am J Respir Crit Care Med. 194, 1366-1374
  • Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Lieb K, Tuscher O, Binder H, Ferreiros N, Tegeder I, Morris AJ, Gropa S, Nürnberg P, Toliat MR, Winterer G, Luhmann HJ, Huai J, Nitsch R (2016). Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO Molecular Medicine. 8, 25-38
  • Volmering E, Niehusmann P, Peeva V, Grote A, Zsurka G, Altmuller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS (2016). Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy. Acta Neuropathologica. 132, 277-288
  • Widdig A, Kessler MJ, Bercovitch FB, Berard JD, Duggleby C, Nürnberg P, Rawlins RG, Sauermann U, Wang Q, Krawczak M, Schmidtke J (2016). Genetic Studies on the Cayo Santiago Rhesus Macaques: A Review of 40 Years Of Research. Am J Primatol. 78, 44-62
  • Yigit G, Wieczorek D, Bogershausen N, Beleggia F, Moller-Hartmann C, Altmuller J, Thiele H, Nürnberg P, Wollnik B (2016). A Syndrome of Microcephaly, Short Stature, Polysyndactyly, and Dental Anomalies Caused by a Homozygous KATNB1 Mutation. Am J Med Genet Part A. 170, 728-733
  • Zaki MS, Heller R, Thoenes M, Nurnberg G, Stern-Schneider G, Nürnberg P, Karnati S, Swan D, Fateen E, Nagel-Wolfrum K, Mostafa MI, Thiele H, Wolfrum U, Baumgart-Vogt E, Bolz HJ (2016). PEX6 is Expressed in Photoreceptor Cilia and Mutated in Deafblindness with Enamel Dysplasia and Microcephaly. Human Mutation. 37, 170-174
  • Zhang R, Thiele H, Bartmann P, Hilger AC, Berg C, Herberg U, Klingmuller D, Nürnberg P, Ludwig M, Reutter H (2016). Whole-Exome Sequencing in Nine Monozygotic Discordant Twins. Twin Res Hum Genet. 19, 60-65

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Linda Partridge

  • Afschar S, Toivonen JM, Hoffmann JM, Tain LS, Wieser D, Finlayson AJ, Driege Y, Alic N, Emran S, Stinn J, Froehlich J, Piper MD, Partridge L (2016). Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proc Natl Acad Sci U S A. 113, 1321-1326
  • Burnouf S, Grönke S, Augustin H, Dols J, Gorsky MK, Werner J, Kerr F, Alic N, Martinez P, Partridge L(2016). Deletion of endogenous Tau proteins is not detrimental in Drosophila. Sci Rep. 6, 23102
  • Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L(2016). Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Rep. 15, 638-650
  • Ding X, Bloch W, Iden S, Ruegg MA, Hall MN, Leptin M, Partridge L, Eming SA (2016). mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 7, 13226
  • Essers P, Tain LS, Nespital T, Goncalves J, Froehlich J, Partridge L (2016). Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice. Sci Rep. 6, 30290
  • Gorsky MK, Burnouf S, Dols J, Mandelkow E, Partridge L(2016). Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Sci Rep. 6, 22685
  • Iyer J, Wang Q, Le T, Pizzo L, Gronke S, Ambegaokar S, Imai Y, Srivastava A, Llamusi Troisi B, Mardon G, Artero R, Jackson GR, Isaacs AM, Partridge L, Kumar JP, Girirajan S (2016). Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster. G3-GenesGenomes Genet (Bethesda). 6, 1427-1437
  • Kakanj P, Moussian B, Grönke S, Bustos V, Eming SA, Partridge L, Leptin M (2016). Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nat Commun. 7, 12972
  • Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L (2016). A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. J Neurosci. 36, 11654-11670
  • Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L (2016). Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications. Brain. In press. DOI: 10.1093/brain/aww185
  • Logan A, Pell VR, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM, Porteous CM, Partridge L, Krieg T, Smith RA, Murphy MP (2016). Assessing the mitochondrial membrane potential in cells and in vivo using targeted click chemistry and mass spectrometry. Cell Metab. 23, 1-7
  • Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L (2016). Increased Glucose Transport intoNeurons Rescues Abeta Toxicity in Drosophila. Curr Biol. 26, 2291-2300
  • Partridge L (2016). Gerontology: Extending the healthspan. Nature. 529, 154-154
  • Partridge L (2016). Comments from the departing Editor. Philos T R Soc B. 371, 20150471
  • Piper MD, Partridge L (2016). Protocols to Study Aging in Drosophila. In (ed) Dahmann, C. Drosophila Methods and Protocols, 2nd ed. Series: Methods Mol Biol 1478, Walker, J.M. (series ed.). pp 291-302. Methods Mol Biol. New York
  • Regan JC, Khericha M, Dobson AJ, Bolukbasi E, Rattanavirotkul N, Partridge L(2016). Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction. eLife. 5, e10956
  • Slack C, Alic N, Partridge L(2016). Could cancer drugs provide ammunition against aging? Cell Cycle. 15, 153-155
  • Sofola-Adesakin O, Khericha M, Snoeren I, Tsuda L, Partridge L (2016). pGluAbeta increases accumulation of Abeta in vivo and exacerbates its toxicity. Acta Neuropathol Commun. 4, 109
  • Soultoukis GA, Partridge L (2016). Dietary Protein, Metabolism, and Aging. Annu Rev Biochem. 85, 5-34
  • Tiku V, Jain C, Raz Y, Nakamura S, Heestand B, Liu W, Spath M, Suchiman HED, Muller RU, Slagboom PE, Partridge L, Antebi A (2016). Small nucleoli are a cellular hallmark of longevity. Nat Commun. 8, 16083

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Manolis Pasparakis

  • Fernandez-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Buttner R, Thomas RK, Schumacher B, Pasparakis M (2016). The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 7: 12508
  • Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J (2016). RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. 353: 603-8
  • Klemann C, Pannicke U, Morris-Rosendahl DJ, Vlantis K, Rizzi M, Uhlig H, Vraetz T, Speckmann C, Strahm B, Pasparakis M, Schwarz K, Ehl S, Rohr JC (2016). Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency. Clin Immunol. 164: 52-6
  • Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Moller P, Lopez C, Schlesner M, Lohneis P, Weber AN, Trumper L, German International Cancer Genome Consortium Molecular Mechanisms in Malignant Lymphoma by Sequencing Project C, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC (2016). B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice. Blood. 127: 2732-41
  • Köhler UA, Bohm F, Rolfs F, Egger M, Hornemann T, Pasparakis M, Weber A, Werner S (2016). NF-kappaB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. J Hepatol. 64: 94-102
  • Körbelin J, Dogbevia G, Michelfelder S, Ridder DA, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt JA, Schwaninger M, Trepel M (2016). A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. EMBO Mol Med. 8: 609-25
  • Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016 Dec 1;540(7631):124-128. doi: 10.1038/nature20558.
  • Najjar M, Saleh D, Zelic M, Nogusa S, Shah S, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen MJ, Pasparakis M, Balachandran S, Kelliher M, Poltorak A, Degterev A (2016). RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. Immunity. 45: 46-59
  • Piaggio F, Kondylis V, Pastorino F, Di Paolo D, Perri P, Cossu I, Schorn F, Marinaccio C, Murgia D, Daga A, Raggi F, Loi M, Emionite L, Ognio E, Pasparakis M, Ribatti D, Ponzoni M, Brignole C (2016). A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects. J Control Release. 223: 165-77
  • Reale C, Iervolino A, Scudiero I, Ferravante A, D'Andrea LE, Mazzone P, Zotti T, Leonardi A, Roberto L, Zannini M, de Cristofaro T, Shanmugakonar M, Capasso G, Pasparakis M, Vito P, Stilo R (2016). NF-kappaB Essential Modulator (NEMO) Is Critical for Thyroid Function. J Biol Chem. 291: 5765-73
  • Strilic B, Yang L, Albarran-Juarez J, Wachsmuth L, Han K, Muller UC, Pasparakis M, Offermanns S (2016). Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 536: 215-8
  • Vlantis K, Polykratis A, Welz PS, van Loo G, Pasparakis M, Wullaert A (2016). TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice. Gut. 65: 935-43
  • Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, Pasparakis M (2016). NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions. Immunity. 44: 553-67
  • Wroblewski R, Armaka M, Kondylis V, Pasparakis M, Walczak H, Mittrucker HW, Schramm C, Lohse AW, Kollias G, Ehlken H (2016). Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice. Hepatology. 64: 508-21

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Mats Paulsson

  • Gebauer JM, Kobbe B, Paulsson M, Wagener R (2016). Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Matrix Biol. 49, 106-119
  • Heilig J, Paulsson M, Zaucke F (2016). Insulin-like growth factor 1 receptor (IGF1R) signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification. Bone. 83, 48-57
  • Kamper M, Hamman N, Prein C, Clausen-Schumann H, Farkas Z, Aszodi A, Niehoff A, Paulsson M, Zaucke F (2016). Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX -/- mice. Matrix Biol. 49, 132-143
  • Kamper M, Paulsson M, Zaucke F (2016). Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the IHH-PTHrP feedback loop. Cell Tissue Res. in press
  • Maaß T, Bayley CP, Mörgelin M, Lettmann S, Bonaldo P, Paulsson M, Baldock C, Wagener R (2016). Heterogeneity of collagen VI microfibrils: Structural analysis of non-collagenous regions. J Biol Chem. 291, 5247-5258
  • Pitzler L, Auler M, Probst K, Frie C, Bergmeier V, Holzer T, Belluoccio D, Van den Bergen J, Etich J, Ehlen H, Zhou Z, Bielke W, Pöschl E, Paulsson M, Brachvogel B (2016). miR-126-3p promotes matrix-dependent perivascular cell attachment, migration and intercellular interaction. Stem Cells. 34, 1297-1309
  • Schiavinato A, Keene DR. Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G (2016). Targeting of EMILIN-1 and EMILIN-2 to fibrillin microfibrils facilitates their incorporation into the extracellular matrix. J Invest Dermatol. 136, 1150-1160
  • Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B (2016). COMP-assisted collagen secretion – a novel intracellular function required for fibrosis. J Cell Sci. 129, 706-716

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Alvaro Rada-Iglesias

  • Nikolić M, Papantonis A, Rada-Iglesias A (2016). GARLIC: A Bioinformatic Toolkit for Etiologically Connecting Diseases and Cell Type-Specific Regulatory Maps. Hum Mol Genet. 2016 Dec 22. pii: ddw423. doi: 10.1093/hmg/ddw423. [Epub ahead of print]
  • Rehimi R, Nikolic M, Cruz-Molina S, Tebartz C, Frommolt P, Mahabir E, Clément-Ziza M, Rada-Iglesias A (2016). Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations. Cell Rep. 2016 Dec 13;17(11):3062-3076
  • Respuela P, Rada-Iglesias A (2016). Enhancer Remodeling During Early Mammalian Embryogenesis:Lessons for Somatic Reprogramming, Rejuvenation, and Aging. Curr Stem Cell Rep. 2016 May 2:263–272
  • Respuela P, Nikolic P, Tan M, Frommolt P, Zhao Y, Wysocka J, Rada-Iglesias A (2016). Foxd3 promotes exit from naïve pluripotency through enhancer decommissioning and inhibits germline specification. Cell Stem Cell. 2016 Jan 7;18(1):118-133. PMID:26748758

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Hans Christian Reinhardt

  • Cramer P, Eichhorst B, Reinhardt HC, Hallek M (2016). Current strategies to create tailored and risk-adapted therapies for CLL patients. Best Pract Res Clin Haematol. 2016 Mar;29(1):111-121. doi: 10.1016/j.beha.2016.08.010. Epub 2016 Aug 12
  • Frenzel LP, Reinhardt HC, Pallasch CP (2016). Concepts of Chronic Lymphocytic Leukemia Pathogenesis: DNA Damage Response and Tumor Microenvironment. Oncol Res Treat. doi:10.1159/000443820, published online Jan 22 2016
  • Herling CD, Klaumünzer M, Krings Rocha C, Altmüller J, Thiele H, Bahlo J, Kluth S, Crispatzu G, Herling M, Schiller J, Engelke A, Tausch E, Döhner H, Fischer K, Goede V, Nürnberg P, Reinhardt HC, Stilgenbauer S, Hallek M, Kreuzer K (2016). Complex karyotypes, KRAS and POT1 mutations impact outcome in CLL after chlorambucil based chemo- or chemoimmunotherapy. Blood. 2016 Jul 21;128(3):395-404. doi: 10.1182/blood-2016-01-691550. Epub 2016 May 25
  • Jokić M, Vlašić I, Rinneburger M, Klümper N, Spiro J, Vogel W, Offermann A, Kümpers C, Fritz C, Schmitt A, Riabinska, Wittersheim M, Michels S, Ozretić L, Florin A, Welcker D, Akyuz MD, Nowak M, Erkel M, Wolf J, Büttner R, Schumacher B, Thomale J, Persigehl T, Maintz D, Perner S, Reinhardt HC (2016). Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a TP53 Context-specific Manner. Molecular Cancer Research. 2016 Aug 11. pii: molcanres.0094.2016. Epub 2016 Aug 11
  • Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber ANR, Trümper L, ICGC MMML-Seq Consortium, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC (2016). B cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B cell lymphoma in mice. Blood. 2016 Jun 2;127(22):2732-41. doi: 10.1182/blood-2015-11-684183. Epub 2016 Apr 5
  • Knittel G, Liedgens P, Korovkina D, Pallasch CP, Reinhardt HC (2016). Rewired NFκB signaling as an actionable feature of activated B cell-like DLBCL. Eur J Haematol. 2016 Aug 16. doi: 10.1111/ejh.12792. Epub 2016 Sep 8
  • Lohmann G, Vasyutina E, Bloehdorn J, Reinart N, Schneider JI, Babu V, Knittel G, Crispatzu G, Mayer P, Prinz C, Biersack B, Efremov DG, Chessa L, Herling CD, Stilgenbauer S, Hallek M, Schobert R, Reinhardt HC, Schumacher B, Herling M (2016). Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia. Leukemia. 2016 Dec 2. doi: 10.1038/leu.2016.294. Epub 2016 Oct 24
  • Thijssen R, ter Burg J, Garrick B, van Bochove GGW, Brown JR, Fernendes SM, Rodriguez M, Michot JM, Hallek M, Eichhorst BF, Reinhardt HC, Bendell J, Derks IAM, van Kampen R, Hege K, Kersten MJ, Trowe T, Filvaroff E, Eldering E, Kater A (2016). Dual TORK/DNA-PK inhibition blocks critical signalling pathways in chronic lymphocytic leukemia. Blood. 2016 Jul 28;128(4):574-83. doi: 10.1182/blood-2016-02-700328. Epub 2016 May 27

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Elena Rugarli

  • König T, Tröder SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, Mühlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli E, De Stefani D, Langer T (2016). The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria. Mol Cell. doi: 10.1016/j.molcel.2016.08.020
  • Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger H-G, Quirós PM, López-Otín C, Rugarli E, Langer T (2016).Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol.  212:157-166. doi:10.1083/jcb.201507022
  • Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli E (2016). The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying. PLoS Genet. 12(12): e1006463. doi:10.1371/journal.pgen.1006463

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Bernhard Schermer

  • Bartram MP, Habbig S, Pahmeyer C, Hohne M, Weber LT, Thiele H, Altmuller J, Kottoor N, Wenzel A, Krueger M, Schermer B, Benzing T, Rinschen MM, Beck BB (2016). Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS. Hum Mol Genet. 25: 1152–1164
  • Bartram MP, Amendola E, Benzing T, Schermer B, de Vita G, Muller RU (2016). Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure. BMC Mol Biol. 17: 11
  • Borgal L, Rinschen MM, Dafinger C, Liebrecht VI, Abken H, Benzing T, Schermer B (2016). Jade-1S phosphorylation induced by CK1alpha contributes to cell cycle progression. Cell Cycle. 15: 1034–1045
  • Braun F, Rinschen MM, Bartels V, Frommolt P, Habermann B, Hoeijmakers JHJ, Schumacher B, Dolle MET, Muller R-U, Benzing T, Schermer B, Kurschat CE (2016). Altered lipid metabolism in the aging kidney identified by three layered omic analysis. Aging (Albany NY). 8: 441–457
  • Gandhirajan RK, Jain M, Walla B, Johnsen M, Bartram MP, Huynh Anh M, Rinschen MM, Benzing T, Schermer B (2016). Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ). J Biol Chem. 291: 11596–11607
  • Ising C, Bharill P, Brinkkoetter S, Brahler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Hohne M, Muller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT (2016). Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier. Am J Pathol. 186: 1128–1139
  • Johnsen M, Späth M, Denzel M, Göbel H, Kubacki T, Hoyer K, Hinze Y, Benzing T, Schermer B, Antebi A, Burst V, Müller R (2016). Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage. PLoS ONE. 11: e0161315
  • Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT (2016). Par3A is dispensable for the function of the glomerular filtration barrier of the kidney. Am J Physiol Renal Physiol. 311: F112-119
  • Koehler S, Brähler S, Kuczkowski A, Binz J, Hackl M, Hagmann H, Höhne M, Vogt M, Wunderlich C, Wunderlich F, Schweda F, Schermer B, Benzing T, Brinkkoetter P (2016). Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion. Sci Rep. 6: 35400
  • Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT (2016). Quantitative deep-mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation. Am J Physiol Cell Physiol ajpcell. 00121.2016
  • Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Hohne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Muller R-U, Kruger M, Benzing T (2016). The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet. 25: 1328–1344
  • Schermer B, Benzing T (2016). Endothelial cilia protect against atherosclerosis. EMBO Rep. 17: 125–126

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Björn Schumacher

  • Ackermann L, Schell M, Pokrzywa W, Kevei E, Gartner B, Schumacher B, Hoppe T (2016). E4 Ubiquitin Ligase Specific Ubiquitylation Hubs Coordinate DNA Double Strand Break Repair and Apoptosis. Nat Struct Mol Biol. 2016 Sep 26. doi: 10.1038/nsmb.3296. Epub 2016 Sep 26
  • Babu V, Schumacher B (2016). A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. DNA Repair (Amst). 2016 Mar 25;41:8-15. doi: 10.1016/j.dnarep.2016.03.008. Epub 2016 Mar 25
  • Barzilai A, Schumacher B, Shiloh Y (2016). Genome Instability: Linking Aging and Brain Degeneration. Mech Ageing Dev. 2016 Mar 31. pii: S0047-6374(16)30039-2. doi: 10.1016/j.mad.2016.03.011. Epub 2016 Mar 31
  • Braun F, Rinschen MM, Bartels V, Frommolt P, Habermann B, Hoeijmakers JH, Schumacher B, Dollé ME, Müller RU, Benzing T, Schermer B, Kurschat CE (2016). Altered lipid metabolism in the aging kidney identified by three layered omic analysis. Aging (Albany NY). 2016 Feb 16
  • Bujarrabal A, Schumacher B (2016).
Hormesis running hot and cold. 
Cell Cycle. 2016 Sep 29:0. 2016 Dec 16;15(24):3335-3336. doi: 10.1080/15384101.2016.1235859. Epub 2016 Sep 29
  • Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M (2016). The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016 Aug 26;7:12508. doi: 10.1038/ncomms12508
  • Jokic M, Vlasic I, Rinneburger M, Klumper N, Spiro J, Vogel W, Offermann A, Kuempers C, Fritz C, Schmitt A, Riabinska A, Wittersheim M, Michels S, Ozretic L, Florin A, Welcker D, Akyuz MD, Nowak M, Erkel M, Wolf J, Buttner R, Schumacher B, Thomale J, Persigehl T, Maintz D, Perner S, Reinhardt HC (2016). Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a TP53 Context-specific Manner. Mol Cancer Res. 2016 Aug 11. pii: molcanres.0094.2016. Epub 2016 Aug 11
  • Lohmann G, Vasyutina E, Bloehdorn J, Reinart N, Schneider JI, Babu V, Knittel G, Crispatzu G, Mayer P, Prinz C, Biersack B, Efremov DG, Chessa L, Herling CD, Stilgenbauer S, Hallek M, Schobert R, Reinhardt HC, Schumacher B, Herling M (2016). 
Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia. 
Leukemia. 2016 Oct 24. doi: 10.1038/leu.2016.294.
  • Nakad R, Schumacher B (2016). DNA Damage Response and Immune Defence: Links and Mechanisms. Front Genet. 09 Aug 2016. doi: 10.3389/fgene.2016.00147
  • Ribezzo F, Shiloh Y, Schumacher B (2016). Systemic DNA damage responses in aging and diseases. Semin Cancer Biol. 2016 Jan 7. pii: S1044-579X(15)30005-5. doi: 10.1016/j.semcancer.2015.12.005 
  • Williams AB, Schumacher B (2016).
 DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity.
 Mech Ageing Dev. 2016 Sep 26. pii: S0047-6374(16)30174-9. doi: 10.1016/j.mad.2016.09.007. [Epub ahead of print]

  • Willams AB, Schumacher B (2016). p53 in the DNA-Damage-Repair Process. Cold Spring Harb Perspect Med. 2016 Apr 5. pii: a026070. doi: 10.1101/cshperspect.a026070. [Epub ahead of print]

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Günter Schwarz

  • Jakubiczka-Smorag J, Santamaria-Araujo JA, Metz I, Kumar A, Hakroush S, Brueck W, Schwarz G, Burfeind P, Reiss J, Smorag L (2016). Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients. Hum Genet. 2016 Jul;135(7):813-26. doi: 10.1007/s00439-016-1676-4
  • Lal D, Reinthaler EM, Dejanovic B, May P, Thiele H, Lehesjoki AE, Schwarz G, Riesch E, Ikram MA, van Duijn CM, Uitterlinden AG, Hofman A, Steinböck H, Gruber-Sedlmayr U, Neophytou B, Zara F, Hahn A; Genetic Commission of the Italian League against Epilepsy.; EuroEPINOMICS CoGIE Consortium., Gormley P, Becker F, Weber YG, Cilio MR, Kunz WS, Krause R, Zimprich F, Lemke JR, Nürnberg P, Sander T, Lerche H, Neubauer BA (2016). Evaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes. PLoS One. 2016 Mar 18;11(3):e0150426. doi: 10.1371/journal.pone.0150426
  • Santamaria-Araujo JA, Wray V, Schwarz G (2016). Erratum to: Structure and stability of the molybdenum cofactor intermediate cyclic pyranopterin monophosphate. J Biol Inorg Chem. 2016 Apr;21(2):293. doi: 10.1007/s00775-015-1321-z. No abstract available
  • Schwarz G (2016). Molybdenum cofactor and human disease. Curr Opin Chem Biol. 2016 Apr;31:179-87. doi: 10.1016/j.cbpa.2016.03.016. Review

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Philipp Steven

  • Khatib R, Göbel H, Kurschat C, Röcken C, Cursiefen C, Steven P, Hendl LM (2016). Refractory pseudofollicular conjunctivitis. Ophthalmologe. 2016 Jul;113(7):612-4. doi: 10.1007/s00347-015-0169-5
  • Notara M, Refaian N, Braun G, Steven P, Bock F, Cursiefen C (2016). Short-Term Ultraviolet A Irradiation Leads to Dysfunction of the Limbal Niche Cells and an Antilymphangiogenic and Anti-inflammatory Micromilieu. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):928-39. doi: 10.1167/iovs.15-18343
  • Schrittenlocher SA, Hiss S, Haneder S, Otte M, Luers JC, Steven P (2016). Unilateral Papillary Edema Due to Sinus Mucocele. Klin Monbl Augenheilkd. 2016 Dec;233(12):1378-1380. Epub 2016 Jul 6
  • Siebelmann S, Bachmann B, Lappas A, Dietlein T, Hermann M, Roters S, Cursiefen C, Steven P (2016). Intraoperative optical coherence tomography in corneal and glaucoma surgical procedures. Ophthalmologe. 2016 Aug;113(8):646-50. doi:10.1007/s00347-016-0320-y
  • Siebelmann S, Gehlsen U, Le Blanc C, Stanzel TP, Cursiefen C, Steven P (2016). Detection of graft detachments immediately following Descemet Membrane endothelial keratoplasty (DMEK) comparing time domain and spectral domain OCT. Graefes Arch Clin Exp Ophthalmol. 2016 Dec;254(12):2431-2437. Epub 2016 Aug 26
  • Siebelmann S, Bachmann B, Lappas A, Dietlein T, Steven P, Cursiefen C (2016). Intraoperative optical coherence tomography for examination of newborns and infants under general anesthesia. Ophthalmologe. 2016 Aug;113(8):651-5. doi:10.1007/s00347-016-0299-4
  • Siebelmann S, Steven P, Cursiefen C (2016). Intraoperative Optical Coherence Tomography In Deep Anterior Lamellar Keratoplasty. Klin Monbl Augenheilkd. 2016 Jun;233(6):717-21. doi: 10.1055/s-0042-108588. Epub 2016 Jun 17
  • Siebelmann S, Bucher F, Grajewski RS, Steven P (2016). Topical Anti-Inflammatory Therapy Options. Klin Monbl Augenheilkd. 2016 Feb 15. [Epub ahead of print] 
  • Siebelmann S, Steven P, Hos D, Hüttmann G, Lankenau E, Bachmann B, Cursiefena C (2016). Errata: Advantages of microscope-integrated intraoperative online optical coherence tomography: usage in Boston keratoprosthesis type I surgery. J Biomed Opt. 2016 Feb;21(2):29801. doi: 10.1117/1.JBO.21.2.029801
  • Siebelmann S, Steven P, Hos D, Hüttmann G, Lankenau E, Bachmann B, Cursiefen C (2016). Advantages of microscope-integrated intraoperative online optical coherence tomography: usage in Boston keratoprosthesis type I surgery. J Biomed Opt. 2016 Jan;21(1):16005. doi: 10.1117/1.JBO.21.1.016005. Erratum in: J Biomed Opt. 2016 Feb;21(2):29801. Hüttmann, Gereon [added]
  • Tahmaz V, Gehlsen U, Sauerbier L, Holtick U, Engel L, Radojska S, Petrescu-Jipa VM, Scheid C, Hallek M, Gathof B, Cursiefen C, Steven P (2016). Treatment of severe chronic ocular graft-versus-host disease using 100% autologous serum eye drops from a sealed manufacturing system: a retrospective cohort study. Br J Ophthalmol. 2016 Jun 6. pii: bjophthalmol-2015-307666. doi:10.1136/bjophthalmol-2015-307666. [Epub ahead of print]

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Wilhelm Stoffel

  • Stoffel W, Hammels I, Jenke B, Binczek E, Schmidt-Soltau I, Brodesser S, Schauss A, Etich J, Heilig J, Zaucke F (2016). Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition. Cell Death Dis. 2016 Nov 24;7(11):e2488. doi: 10.1038/cddis.2016.385

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Peter Tessarz

  • Maleszewska M, Mawer JSP, Tessarz P (2016). Histone modifications in Ageing and Lifespan regulation. Curr Mol Biol Rep. 2 (1), 26-35

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Aleksandra Trifunovic

  • Guarás A, Perales-Clemente E, Calvo E, Acín-Pérez R, Loureiro-Lopez M, Pujol C, Martínez-Carrascoso I, Nuñez E, García-Marqués F, Rodríguez-Hernández MA, Cortés A, Diaz F, Pérez-Martos A, Moraes CT, Fernández-Silva P, Trifunovic A, Navas P, Vazquez J, Enríquez JA (2016). The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency. Cell Rep. 2016 Apr 5;15(1):197-209. doi: 10.1016/j.celrep.2016.03.009
  • Islam S, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M (2016). Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum Mol Genet. 2016 Oct 29. pii: ddw352. [Epub ahead of print]
  • Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, Kukat A, Trifunovic A (2016).Loss of ClpP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt”. EMBO Rep. 2016 Jul;17(7):953-64. doi: 10.15252/embr.201642077
  • Szczepanowska K, Maiti P, Kukat A, Hofetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016). CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J.2016 Dec 1;35(23):2566-2583

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Mirka Uhlirova

  • Mundorf J, Uhlirova M (2016). The Drosophila imaginal disc tumor model: visualization and quantification of gene expression and tumor invasiveness using genetic mosaics. J Vis Exp. 2016 Oct 6;(116). doi: 10.3791/54585

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Dario Valenzano

  • Harel I, Valenzano DR, Brunet A (2016). Efficient genome engineering in the short-lived African turquoise killifish. Nature Protocols. Oct; 11(10):2010-2028
  • Kim Y, Nam HG, Valenzano DR (2016). The short-lived African turquoise killifish: an emerging experimental model for ageing. Dis Model Mech. 9 (2), 115-129
  • Šajina A, Valenzano DR (2016). An In Silico Model to Simulate the Evolution of Biological Aging. arXiv preprint arXiv.1602.00723

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David Vilchez

  • Lee HJ, Gutierrez-Garcia R, VilchezD (2016). Embryonic stem cells: A novel approach to study proteostasis? FEBS Journal. doi:10.1111/febs.13810
  • Noormohammadi A, Khodokarami A, Gutierrez-Garcia R, Lee HJ, Koyuncu S, König T, Schindler C, Saez I, Fatima A, Dieterich C, Vilchez D (2016). Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. NatureCommunications. 7: 13649
  • Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T (2016).The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Human Molecular Genetics. 1(3): 1328-1344

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Sara Wickström

  • Chacon-Martinez CA, Klose M, Niemann C, Glauche I, Wickström SA(2016). Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny. EMBOJ. Dec 9. pii: e201694902. Epub 2016 Dec 9
  • Krenn PW, Hofbauer SW, Pucher S, Hutterer E, Hinterseer E, Asslaber D, Sternberg C, Neureiter D, Aberger F, WickströmSA, Egle A, Greil R, Hartmann TN (2016). Integrin-linked kinase is induced by TNFα-NF-κB signals and required for centrosome clustering in chronic lymphocytic leukemia cells. Cancer Res. 76, 2186-2196
  • Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA (2016). Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol. 18, 864-875

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Rudolf J. Wiesner

  • Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GKH, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ, Hrabě de Angelis M (2016). Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ treated diabetic mice. Diabetes. 65: 2540-2552
  • Lehtonen JM, Forsström S, Isohanni P, Viscomi C, Baris OR, Isoniemi H, Höckerstedt K, Österlund P, Hurme M, Jylhävä J, Leppä S, Markkula R, Heliö T, Mombelli G, Laaksonen R, Zeviani M, Smeitink J, Wiesner RJ, Nakada K, Suomalainen A (2016). Blood FGF21 is a biomarker for mitochondrial translation defects, not for non-mitochondrial diseases. Neurology.87: 2290-2299
  • Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016). CLPP coordinates mitoribosomal assembly through regulation of ERAL1 levels. EMBO J.35: 2566-2583

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Thomas Wunderlich

  • Klebow S, Hahn M, Nikoalev A, Wunderlich FT, Hövelmeyer N, Karbach SH, Waisman A (2016). IL-6 Signaling in Myelomonocytic Cells Is Not Crucial for the Development of IMQ-Induced Psoriasis. PLoS One. 2016 Mar 21;11(3):e0151913
  • Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L; German International Cancer Genome Consortium Molecular Mechanisms in Malignant Lymphoma by Sequencing Project Consortium., Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC (2016). B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice. Blood. 2016 Jun 2;127(22):2732-41
  • Koehler S, Brähler S, Kuczkowski A, Binz J, Hackl MJ, Hagmann H, Höhne M, Vogt MC, Wunderlich CM, Wunderlich FT, Schweda F, Schermer B, Benzing T, Brinkkoetter PT (2016). Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion. Sci Rep. 2016 Oct 19;6:35400
  • Nguyen PH, Fedorchenko O, Rosen N, Koch M, Barthel R, Winarski T, Florin A, Wunderlich FT, Reinart N, Hallek M (2016). LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia. Cancer Cell. 2016 Oct 10;30(4):610-622
  • Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC (2016). AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell. 2016 Mar 24;165(1):125-38

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Branko Zevnik

  • Kaczmarczyk L, Mende Y, Zevnik B, Jackson WS (2016). Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9. PLoS One. 2016 Apr 29;11(4):e0154604. doi: 10.1371/journal.pone.0154604. eCollection 2016

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