CECAD

Cell autonomous control of homeostatic mechanisms and cellular stress responses in aging and age-associated diseases

Aging is characterized by the decline of physiological integrity, which culminates in functional defects and increased risk for age-associated diseases. Cell autonomous deficits include disturbances in cellular proteostasis, organellar homeostasis, and genome integrity, which in turn can elicit multiple adaptive signaling pathways and cellular stress responses. Work of CECAD PIs has begun to unravel the underlying cell autonomous mechanisms contributing to the decline of cellular functions during aging. The concerted analysis of key lifespan determinants by CECAD PIs has revealed a strong interdependence of different cell autonomous deficits that now need to be considered to provide an integrated and detailed overview on the decline of cellular activities during aging and their relationship to the onset and development of age-associated diseases. The key objectives of RA-1 are to investigate:

  1. cell autonomous mechanisms underlying aging focusing on proteostasis, mitochondrial function, organellar homeostasis, DNA damage responses (DDRs), and nutrient sensing mechanisms,
  2. the crosstalk between different cell autonomous mechanisms to obtain an integrated overview of the deterioration of cellular function with aging,
  3. how disturbances of cell autonomous mechanisms cause neurodegeneration and other age-associated diseases,
  4. the relevance of these lifespan determinants in populations of elderly humans.

 

Prof. Dr. Thomas Langer
Head of Research Area 1, Principal Investigator, Director of the MPI for Biology of Ageing
 +49 (0)221 37970 0
Langer[at]age.mpg.de

Max-Planck-Institut für Biologie des Alterns
Joseph-Stelzmann-Str. 9b
50931 Köln
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Prof. Dr. Aleksandra Trifunovic
Head of Research Area 1, Principal Investigator, Institute for Genetics
 +49 221 478 842 91
aleksandra.trifunovic[at]uk-koeln.de

CECAD Research Center
Universität zu Köln
Joseph-Stelzmann-Str. 26
50931 Köln
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Figures

Figure 1: Purkinje nerve cells link the granular to the molecular layer of the cerebellar cortex. This brain region controls balance and muscle coordination.

Figure 2: View of the network of nerve cells in the brain.

Figure 3 and 6: Absence of mitochondrial fusion leads to mitochondrial fragmentation and respiratory incompetence. Fzo1 is essential for the presence of tubular mitochondria. Mitochondrial morphology of (a) wild-type and (b) Δfzo1 yeast cells expressing a mitochondrial-targeted GFP protein. Cellular (Nomarsky) and mitochondrial (GFP) morphology were visualized by fluorescence microscopy.

Figure 4: An example of a model organism used for research: the threadworm C. elegans.

Figure 5: Mitochondria are dynamic parts of the cell.