Mitochondria produce antioxidants to protect our cells from dying

19.01.2023 | TopNews Prof. Dr. Thomas Langer

The enzyme STARD7 (green) helps mitochondria (red) to transport Coenzyme Q to protect cells from cell death. Copyright: S. Deshwal/ Max Planck Institute for Biology of Ageing, 2022

Coenzyme Q distribution within the cell is regulated by mitochondria

Antioxidants are often advertised as a cure-all in nutrition and offered as dietary supplements. However, our body also produces such radical scavengers itself, one of which is coenzyme Q. Now researchers from the Max Planck Institute for Biology of Ageing and CECAD have discovered how the substance, which is produced in our mitochondria, reaches the cell surface and protects our cells from dying.

Coenzyme Q is an antioxidant that is essential for our body. A deficiency of coenzyme Q leads to serious diseases such as Leigh syndrome - a hereditary disease in which certain brain regions become affected and, among other things, muscle weakness can occur. A deficiency of coenzyme Q is also one of the first signs of ageing and can occur as early as the early 20s. But why can't we simply take this substance in with our food?

Highly hydrophobic

"Coenzyme Q is a highly hydrophobic molecule that our bodies absorb very little from food," explains Soni Deshwal, scientist at the Max Planck Institute for Biology of Aging and lead author of the study. But it is also a problem in our cells that coenzyme Q is not water soluble. The antioxidant is formed in mitochondria and must pass through the watery cell interior called cytoplasm to the surface of the cells in order to neutralize oxidized lipid species.

“With our research, we have now been able to identify the proteins involved in coenzyme Q transport from the mitochondria to the cell surface”, explains Deshwal. The researchers found that an enzyme called STARD7 helps transport the coenzyme. This protein is not only localized in the mitochondria, but also inside the cytoplasm.

Band-aids for the cell surface

“The mitochondria actively transport coenzyme Q to the cell surface to protect cells from cell death. It is as if the mitochondria deliver band-aids to the surface to protect the cell”, says Deshwal. "This again shows that mitochondria are not only important as an energy supplier for our cells, but also play crucial regulatory roles."

In the long term, the researchers hope that a precise understanding of this transport process will enable Coenzyme Q to be delivered into the cells of affected patients and thus provide a new therapeutic approach for diseases such as Leigh syndrome.

The research for this study was conducted at the Max Planck Institute for Biology of Ageing and was funded by the CECAD Cluster of Excellence for Aging Research.

Original publication:

Soni Deshwal, Mashun Onishi, Takashi Tatsuta, Tim Bartsch, Eileen Cors, Katharina Ried, Kathrin Lemke, Hendrik Nolte, Patrick Giavalisco, Thomas Langer
Mitochondria regulate intracellular coenzyme Q transport and

ferroptotic resistance via STARD7
Nature Cell Biology, December 1st, 2022
LINK

Contact:

Scientific Contact: Soni Deshwal, PhD

Max Planck Institute for Biology of Aging, Cologne

E-mail: Soni.Deshwal[at]age.mpg.de

Press and public relations: Dr. Maren Berghoff

Max Planck Institute for Biology of Aging, Cologne

Tel.: +49 (0)221 379 70 207

E-mail: maren.berghoff[at]age.mpg.de