03.11.2021 | TopNews Prof. Dr. Thomas Benzing Prof. Dr. Roman-Ulrich Müller
Research on the interaction between proteins is a focus of many groups both in basic and medical science. Much less is known about the contribution of RNA-protein interactions to human disease. RNA-binding proteins (RBPs) are involved in every step of the life cycle of an RNA. However, RNA can also regulate protein function vice-versa. With the number of known RBPs exceeding over 1000 in the human genome, these proteins, have a major impact on cellular biology clearly indicating their importance for human disease.
“We have worked the past years on identifying novel RBPs in kidney cells as well as their modulation by pathways important to kidney health and disease. Our findings and also the lack of an overview was the motivation to prepare our paper“, said Lisa Seufert, the first author of the study.
“Our review provides the first concise and exhaustive overview of the role of RBPs in kidney disease. We point out how the growing knowledge on RNA-protein interactions may have an important contribution to novel therapeutic strategies which are often lacking regarding pathologies of the kidney”, said Müller.
RBPs in the kidney