CECAD

Publications 2019

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Adam Antebi

  • Annibal A, Tam H, Latza C, Antebi A. (2019) Comparison of ESI-MS/MS and APCI-MS methods for the quantification of folic acid analogs in C. elegans. Journal of Mass Spectrometry 10.1002/jms.4337 (in press) 

Susanne Brodesser

  • Yu H, Dilbaz S, Coßmann J, Hoang AC, Diedrich V, Herwig A, Harauma A, Hoshi Y, Moriguchi T, Landgraf K, Körner A, Lucas C, Brodesser S, Balogh L, Thuróczy J, Karemore G, Kuefner MS, Park EA, Rapp C, Travers JB, Röszer T. (2019) Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. J Clin Invest 130:2485-99
  • Braun F, Blomberg L, Brodesser S, Liebau MC, Schermer B, Benzing T, Kurschat CE. (2019) Enzyme Replacement Therapy Clears Gb3 Deposits from a Podocyte Cell Culture Model of Fabry Disease but Fails to Restore Altered Cellular Signaling. Cell Physiol Biochem 52(5):1139-50
  • Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI. (2019) Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia [Epub ahead of print]
  • Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L (2019) Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep 20(4):e47407
  • Farowski F, Solbach P, Tsakmaklis A, Brodesser S, Cruz Aguilar MR, Cornely OA, Dettmer K, Higgins PG, Suerbaum S, Jazmati N, Oefner PJ, Vehreschild MJGT. (2019) Potential biomarkers to predict outcome of faecal microbiota transfer for recurrent Clostridioides difficile infection. Dig Liver Dis [Epub ahead of print]
  • Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC. (2019) CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. Cell Rep 26(1):1-10
  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM. (2019) The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int 95(2):333-49
  • Rashid T, Nemazanyy I, Paolini C, Tatsuta T, Crespin P, de Villeneuve D, Brodesser S, Benit P, Rustin P, Baraibar MA, Agbulut O, Olivier A, Protasi F, Langer T, Chrast R, de Lonlay P, de Foucauld H, Blaauw B, Pende M. (2019) Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. EMBO J 38(1):e99576

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Oliver Cornely

  • Seidel D, Meissner A, Lackner M, Piepenbrock E, Salmanton-Garcia J, Stecher M, Mellinghoff S, Hamprecht A, Duran Graeff L, Kohler P, Cheng MP, Denis J, Chedotal I, Chander J, Pakstis DL, Los-Arcos I, Slavin M, Montagna MT, Caggiano G, Mares M, Trauth J, Aurbach U, Vehreschild M, Vehreschild JJ, Duarte RF, Herbrecht R, Wisplinghoff H, Cornely OA. Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope((R)). Crit Rev Microbiol 2019: 1-21.
  • Mellinghoff SC, Vehreschild JJ, Liss BJ, Cornely OA. Metadata Correction: Epidemiology of Surgical Site Infections With Staphylococcus aureus in Europe: Protocol for a Retrospective, Multicenter Study. JMIR Res Protoc 2019; 8(1): e10712.
  • Koehler P, Mellinghoff SC, Lagrou K, Alanio A, Arenz D, Hoenigl M, Koehler FC, Lass-Florl C, Meis JF, Richardson M, Cornely OA. Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology. J Antimicrob Chemother 2019.
  • Koehler P, Jung N, Cornely OA, Rybniker J, Fatkenheuer G. Combination Antimicrobial Therapy for Enterococcus faecalis Infective Endocarditis. Clin Infect Dis 2019.
  • Gerding DN, Cornely OA, Grill S, Kracker H, Marrast AC, Nord CE, Talbot GH, Buitrago M, Gheorghe Diaconescu I, Murta de Oliveira C, Preotescu L, Pullman J, Louie TJ, Wilcox MH. Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials. Lancet Infect Dis 2019.
  • Farowski F, Solbach P, Tsakmaklis A, Brodesser S, Cruz Aguilar MR, Cornely OA, Dettmer K, Higgins PG, Suerbaum S, Jazmati N, Oefner PJ, Vehreschild M. Potential biomarkers to predict outcome of faecal microbiota transfer for recurrent Clostridioides difficile infection. Dig Liver Dis 2019
  • Oladele RO, Osaigbovo, II, Ayanlowo OO, Otu AA, Hoenigl M, Cornely OA, Chakrabarti A, Denning DW (2019). The role of medical mycology societies in combating invasive fungal infections in low- and middle-income countries: A Nigerian model. Mycoses 2019 Jan;62(1):16-21. doi: 10.1111/myc.12845. Epub 2018 Oct 8       
  • Mellinghoff SC, von Bergwelt-Baildon M, Schosser HA, Cornely OA (2019). A novel approach to candidemia? The potential role of checkpoint inhibition. Med Mycol. 2019 Feb 1;57(2):151-154. doi: 10.1093/mmy/myy089

Martin Denzel

  • Sawarkar R, Scherz-Shouval R, Denzel MS, Saarikangas J (2019). Chaperoning junior faculty: Institutional support and guidance can relieve challenges for early-career group leaders and improve academic performance. EMBO Rep. 2019 Jan;20(1). pii: e47163. doi: 10.15252/embr.201847163. Epub 2018 Nov 23    

Sabine Eming

  • Kiesewetter A, Cursiefen C, Eming SA, Hos D (2019). Phase-specific functions of macropahges determine injury-medoated coneal hem- and lymphangiogenesis. Sci Rep 9:308.

Mafalda Escobar-Henriques

  • Escobar-Henriques M, Joaquim M. (2019) Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases. Front Physiol. 2019 May 9;10:517. doi: 10.3389/fphys.2019.00517. eCollection 2019. Review. PMID: 31156446

Martin Graef

  • Medeiros TC, and Graef M (2019). Autophagy determines mtDNA copy number dynamics during starvation. Autophagy15, 178-179

Thorsten Hoppe       

  • Finger F, Ottens F,Springhorn A, Drexel T, Proksch L, Metz S, Cochella L, Hoppe T (2019). Olfaction regulates organismal proteostasis and longevity via miRNA-dependent signaling. Nat. Metab. (in press)          
  • Springhorn A, Hoppe T (2019). Western blot analysis of the autophagosomal membrane protein LGG-1/LC3 in Caenorhabditis elegans. Method Enzymol. (accepted)

Tamas Horvath      

  • Stutz B, Nasrallah C, Nigro M, Curry D, Liu ZW, Gao XB, Elsworth JD, Mintz L, Horvath TL: Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Mol Metab. 2019 Feb 21; 2019 Feb 21. PMID: 30833218
  • Seli E, Wang T, Horvath TL: Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertil Steril. 2019 Feb. PMID: 30691623

Frank Jessen

  • Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L,  Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT Jr, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall  DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Caltagirone C, Bossù P, Orfei MD, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Slifer S, Seeley WW, Smith AG,  Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Saba Y; Alzheimer Disease Genetics Consortium (ADGC),; European Alzheimer’s Disease Initiative (EADI),; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),; Genetic and Environmental Risk inAD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),, Pilotto A, Bullido MJ, Peters O, Crane PK, BennettD, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL,Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM,Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG, Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, C O'Donovan M, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019 Mar;51(3):414-430. doi:10.1038/s41588-019-0358-2. Epub 2019 Feb 28. PubMed PMID: 30820047.
  • Escher CM, Sannemann L, Jessen F. Stress and Alzheimer's disease. J Neural Transm (Vienna). 2019 Feb 20. doi: 10.1007/s00702-019-01988-z. [Epub ahead of print] Review. PubMed PMID: 30788601.
  • Dalmasso MC, Brusco LI, Olivar N, Muchnik C, Hanses C, Milz E, Becker J, Heilmann-Heimbach S, Hoffmann P, Prestia FA, Galeano P, Avalos MSS, Martinez LE, Carulla ME, Azurmendi PJ, Liberczuk C, Fezza C, Sampaño M, Fierens M, Jemar G, Solis P, Medel N, Lisso J, Sevillano Z, Bosco P, Bossù P, Spalletta G, Galimberti D, Mancuso M, Nacmias B, Sorbi S, Mecocci P, Pilotto A, Caffarra P, Panza F, Bullido M, Clarimon J, Sánchez-Juan P, Coto E, Sanchez-Garcia F, Graff C, Ingelsson M, Bellenguez C, Castaño EM, Kairiyama C, Politis DG, Kochen S, Scaro H, Maier W, Jessen F, Mangone CA, Lambert JC, Morelli L, Ramirez A. Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease. Transl Psychiatry. 2019 Jan 31;9(1):55. doi: 10.1038/s41398-019-0394-9. PubMed PMID: 30705288; PubMed Central PMCID: PMC6355764.
  • Haidl TK, Seves M, Eggers S, Rostamzadeh A, Genske A, Jünger S, Woopen C, Jessen F, Ruhrmann S, Vogeley K. Health literacy in clinical-high-risk individuals for psychosis: A systematic mixed-methods review. Early Interv Psychiatry. 2019 Jan 27. doi: 10.1111/eip.12776. [Epub ahead of print] Review. PubMed PMID: 30688012.
  • Jessen F. Early detection of Alzheimer's disease and approaches for prevention. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Jan 24. doi: 10.1007/s00103-019-02877-2. [Epub ahead of print] Review. German. PubMed PMID: 30680409.
  • Wolfsgruber S, Molinuevo JL, Wagner M, Teunissen CE, Rami L, Coll-Padrós N, Bouwman FH, Slot RER, Wesselman LMP, Peters O, Luther K, Buerger K, Priller J, Laske C, Teipel S, Spottke A, Heneka MT, Düzel E, Drzezga A, Wiltfang J, Sikkes SAM, van der Flier WM, Jessen F, Euro-SCD working group. Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples. Alzheimers Res Ther. 2019 Jan 17;11(1):8. doi: 10.1186/s13195-018-0463-y. PubMed PMID: 30654834; PubMed Central PMCID: PMC6337830.
  • Jagust W, Jack CR Jr, Bennett DA, Blennow K, Haeberlein SB, Holtzman DM, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Sperling R. "Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia". Alzheimers Dement. 2019 Jan;15(1):153-157. doi: 10.1016/j.jalz.2018.11.002. PubMed PMID: 30642435.
  • Meiberth D, Rapp MA, Jessen F. Memory Clinics in Germany - Results of a Hospital Survey. Psychiatr Prax. 2019 Jan 14. doi: 10.1055/a-0825-9049. [Epub ahead of print] German. PubMed PMID: 30641612.
  • Schüller CB, Kuhn J, Jessen F, Hu X. Neuronal correlates of delay discounting in healthy subjects and its implication for addiction: an ALE meta-analysis study. Am J Drug Alcohol Abuse. 2019;45(1):51-66. doi:10.1080/00952990.2018.1557675. Epub 2019 Jan 11. PubMed PMID: 30632802.

Peter Kloppenburg

  • Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI. Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. 2019 Apr 16. doi: 10.1002/glia.23626. [Epub ahead of print] PMID: 30989755 [PubMed - as supplied by publisher]

 

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Natalia Kononenko

  • Bera S, Calleja E, Wittich C, Negrete-Hurtado A, Racho J, Ellrich N, Martins S, Adjaye J, Kononenko NL. Endocytic adaptor AP-2 prevents amyloidogenic processing of APP via endocytosis-independent regulation of BACE1 trafficking in neurons (eLife, submitted 2019).
  • Upadhyay A, Hosseinibarkooie M, Schneider S, Kaczmarek A, Torres-Benito L, Natalia Mendoza-Ferreira N, Overhoff M, Rombo R, Grysko V, Kye MJ, Kononenko NL*, Wirth B*. Neurocalcin delta knockout impairs adult neurogenesis whereas half reduction is a safe therapeutic option for spinal muscular atrophy. Front. Mol. Neurosci. Feb 12;19:1-15 (2019). *-shared corresponding author
  • Kononenko NL, Hartfil S, Willer J, Ferch J, Wolfenberg H, Pflueger HJ. A population of descending tyraminergic/octopaminergic projection neurons of the insect. J Comp Neurol. Apr 15;527:1027-1038 (2019).

Marcus Krüger

  • Jachimowicz RD, Bhavana VB, Beleggia F, Isensee J, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, and Shiloh Y(2018) UBQLN4 regulates double-strand break repair by repressing homologous recombination and is overexpressed in aggressive tumors, Cell. 2019 Jan 24; 176 (3):505-519

Thomas Langer

  • Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI. Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. 2019 Apr 16. doi: 10.1002/glia.23626. [Epub ahead of print] PMID: 30989755 [PubMed - as supplied by publisher]
  • Tatsuta T, Langer T (2019). Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins. Nature Communications. (accepted)
  • Sprenger HS, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T (2019). Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2019 Jan;11(1). pii: e9288. doi: 10.15252/emmm.201809288                  
  • Rashid T, Nemazanyy I, Paolini C, Tatsuta T, Crespin P, de Villeneuve D, Brodesser S, Benit P, Rustin PA, Baraibar M, Agbulut O, Olivier A, Protasi F, Langer T, Chrast R, de Lonlay P, de Foucauld H, Blaauw B, Pende M (2019). Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. Embo J. 2019 Jan 3;38(1). pii: e99576. doi: 10.15252/embj.201899576. Epub 2018 Nov12               
  • Richter F, Dennerlein S, Nikolov M, Jans D, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P (2019). ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. J Cell Biol. 4;218(2):598-614. doi: 10.1083/jcb.201806093-

Maria Leptin

  • Wollrab V, Belmonte JM, Baldauf L, Leptin M, Nédeléc F, Koenderink GH. Polarity sorting drives remodeling of actin-myosin networks (2019). J Cell Sci. 132: jcs219717 

Roman-Ulrich Müller

  • Ignarski M, (…) Fabretti F, Müller R-U. The RNA-protein interactome of differentiated kidney tubular epithelial cells. J. Am. Soc. Nephrol.  (2019) (JASN-2018-09-0914.R3; accepted for publication 20.01.2019)
  • Jain M, Kaiser RWJ, Bohl K, Hoehne M, Göbel H, Bartram MP, Habbig S, Müller R-U, Fogo AB, Benzing T, Schermer B, Höpker K, Slaats GG. Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis. Kidney Int. (2019) doi: 10.1016/j.kint.2018.10.034
  • Rinschen MM, Müller RU (2019). A knowledge-guided kidney cell census-reconciling bulk omics with cellular heterogeneity? Kidney Int. 2019 Apr;95(4):733-735. doi: 10.1016/j.kint.2018.12.016
  • Braun F, Suarez V, Dinter J, Haneder S, Quaas A, Benzing T, Nierhoff D, Müller RU (2019). Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura. BMJ Open Gastroenterol. 2019 Feb 8;6(1):e000252. doi: 10.1136/bmjgast-2018-000252. eCollection 2019

Carien Niessen

  • Persa OD, Niessen CM. Epithelial polarity limits EMT. Nat Cell Biol. 2019 Mar;21(3):299-300. doi: 10.1038/s41556-019-0284-7. No abstract available. PMID: 30824839

Peter Nürnberg

  • Prasetyanti PR, Hooff SR van, van Herwaarden T, de Vries N, Kalloe K, Rodermond H, van Leersum R, de Jong JH, Franitza M, Nurnberg P, Todaro M, Stassi G, Medema JP (2019). Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models. Int J Cancer 2019 Jan 15;144(2):366-371. doi: 10.1002/ijc.31767. Epub 2018 Oct 22

Linda Partridge

  • Weigelt CM, Hahn O, Arlt K, Gruhn M, Jahn AJ, Esser J, Werner JA, Klein C, Buschges A, Gronke S, Partridge L (2019). Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster. Life Sci Alliance. 2, e201800149.
  • Fuentealba M, Dönertaş HM, Williams R, Labbadia J, Thornton JM, Partridge L (2019). Using the drug-protein interactome to identify anti-ageing compounds for humans. PLoS Comput Biol. 15, e1006639.
  • Moens TG, Niccoli T, Wilson KM, Atilano ML, Birsa N, Gittings LM, Holbling BV, Dyson MC, Thoeng A, Neeves J, Glaria I, Yu L, Bussmann J, Storkebaum E, Pardo M, Choudhary JS, Fratt, P, Partridge L, Isaacs AM (2019). C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathol.In press

Manolis Pasparakis  

  • Krishna-Subramanian S, Singer S, Armaka M, Banales JM, Holzer K, Schirmacher P, Walczak H, Kollias G, Pasparakis M, Kondylis V. RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death Differ. 2019 Apr 15. doi: 10.1038/s41418-019-0330-9. [Epub ahead of print] PMID: 30988397 [PubMed - as supplied by publisher]
  • Kondylis V, Pasparakis M (2019). RIP Kinases in Liver Cell Death, Inflammation and Cancer. Trends Mol Med. 2019 Jan;25(1):47-63. doi: 10.1016/j.molmed.2018.10.007. Epub 2018 Nov 16      
  • Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke H, Fava LL, Haschka MD, Glatter T, Nesvizhskii A, Schmidt A, Harris PA, Bertin J, Gough PJ, Villunger A, Silke J, Pasparakis M, Bianchi K, Meier P (2019). RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell. 2019 Feb 7;73(3):413-428.e7. doi: 10.1016/j.molcel.2018.11.010. Epub 2018 Dec 28               
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Elena Rugarli

  • Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G. The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα. Nat Commun. 2019 Apr 5;10(1):1566. doi: 10.1038/s41467-019-09598-9. PMID: 30952952
  • Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI. Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. 2019 Apr 16. doi: 10.1002/glia.23626. [Epub ahead of print] PMID: 30989755 [PubMed - as supplied by publisher]
  • Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola A, Wai T, Barth E, Rugarli EI, Bergami M, and Langer T. (2019) Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 11, pii: e9288. doi 10.15252/emmm. 201809288

Björn Schumacher

  • Jachimowicz RD, Beleggia F, Isensee J, Bhavana VB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Pfeifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y (2019). UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors. Cell, 2019 Jan 24;176, 1-15. doi: 10.1016/j.cell.2018.11.024     

Eline Slagboom

  • van den Berg N, Rodríguez-Girondo M, van Dijk IK, Mourits RJ, Mandemakers K, Janssens AAPO, Beekman M, Smith KR, Slagboom PE. Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait. Nat Commun. 2019 Jan 7;10(1):35. doi: 10.1038/s41467-018-07925-0
  • De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9.
  • Meessen JMTA, Fiocco M, Leichtenberg CS, Vliet Vlieland TPM, Slagboom PE, Nelissen RGHH. Frailty Questionnaire Is Not a Strong Prognostic Factor for Functional Outcomes in Hip or Knee Arthroplasty Patients.Geriatr Orthop Surg Rehabil. 2019 Feb 4;10:2151459318808164. doi: 10.1177/2151459318808164.

Marc Tittgemeyer

  • Baldermann JC, Melzer C, Zapf A, Kohl S, Timmermann L, Tittgemeyer M, Huys D, Visser-Vandewalle V, Kühn AA, Horn A and Kuhn J (2019). Connectivity profile predictive of effective deep brain stimulation in obsessive compulsive disorder. Biol Psychiatry, ePub ahead of print
  • Glaab E, Trezzi JP, Greuel A, Jaeger C, Hodak Z, Drzezga A, Timmermann L, Tittgemeyer M, Diederich NJ, Eggers C (2019). Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson’s disease. Neurobiology of Disease 124, 555-562
  • Hammes J, Theis H, Giehl K, Hoenig MC, Greuel A, Tittgemeyer M, Timmermann L, Fink GR, Drzezga A, Eggers C and van Eimeren T (2019). Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control. Brain, ePub ahead of print
  • Lippert RN, Cremer AL, Edwin Thanarajah S, Korn C, Jajans-Price T, Burgeno LM, Tittgemeyer M, Bruening JC, Walton ME, Backes H (2019). Time-dependent assessment of stimulus-evoked regional dopamine release. Nature Communications 10, 336

Mirka Uhlirova

  • Mundorf J, Donohoe CD, McClure CD, Southall TD, Uhlirova M (2019). Ets21c governs tissue renewal, stress tolerance, and aging in the Drosophila intestine. Cell Reports 27, 3019-3033.e5.
  • Cosolo A, Jaiswal J, Csordás G, Grass I, Uhlirova M, Classen A (2019). JNK-dependent cell 1 cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress. ELife, 8:e41036. DOI: 10.7554/eLife.41036

Dario Valenzano

  • Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lehmann K, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L (2019). Loss of genomic integrity by lysosphingolipid imbalance drives ageing in the heart. Embo Rep. (In Press).
  • Keesey I, Grabe V, Gruber L, Koerte S, Obiero G, Bolton G, Khallaf M, Kunert G, Lavista-Llanos S, Valenzano DR, Rybak J, Barrett B, Knaden M, Hansson B (2019).Inverse resource allocation between vision and olfaction across the genus Drosophila.Nat Commun.(In Press).