Vaccelerate Webinar

22.02.2024, 13:00 Virtual Calendar

"Vaccination Hurdles: Navigating the Complexities of Immunizing the Vulnerable" a presentation by Paolo Palma (UOC di Immunologia Clinica e Vaccinologia, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, IT)

Routine vaccination is among the most effective clinical interventions to prevent diseases as it isestimated to save over 3 million lives every year. However, the full potential of globalimmunization programs is not realised because population coverage is still suboptimal.

This is also due to the inadequate immune response and paucity of informative correlates ofprotection upon immunization of vulnerable individuals such as newborns, preterm infants,pregnant women, and elderly individuals as well as those patients affected by chronic andimmune compromising medical conditions.

In addition, these groups are undervaccinated for a number of reasons, including lack ofawareness of vaccine-preventable diseases and uncertainty or misconceptions about the safetyand efficacy of vaccination by parents and healthcare providers. The presence of these non-responders/undervaccinated individuals represents a major health and economic burden tosociety, which will become particularly difficult to address in seƫngs with limited publicresources.

In this webinar, Prof. Palma describes innovative and experimental approaches that can helpidentify specific genomic profiles defining non-responder individuals for whom specificinterventions might be needed. He will provide examples that show how such information can beuseful to identify novel biomarkers of safety and immunogenicity for future vaccine trials.