Scientists in Cologne identify important lysine-acetylation regulatory mechanisms for Ran protein

The team of scientists led by Dr. Michael Lammers at CECAD, the Cluster of Excellence at the University of Cologne, has discovered that the essential cellular protein Ran is fundamentally regulated by lysine acetylation. Ran belongs to the family of Ras proteins, which regulate fundamental cellular processes such as cell differentiation, cell division, and intracellular transport. Mutations in Ras-related proteins are involved in the development of various types of cancer including colorectal cancer, lung cancer, and lymphomas. Mechanisms that can switch off the functions of Ran protein are therefore of particular therapeutic interest.

For more information, please see the press release.