CECAD

Publications 2018

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Adam Antebi

  • Tiku V, Kew C, Mehrotra P, Ganesan R, Robinson N, Antebi A (2018). Nucleolar Fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance. Nat Commun. 9, 3607                  
  • Tiku V, Antebi A (2018). Nucleolar function in life span regulation. Trends Cell Biol. S0962-8924(18) 30063-1. doi: 10.1016/j.tcb.2018.03.007                                                                       
  • Annibal A, Karalay O, Latza C, Antebi A (2018). A novel EI-GC/MS method for the accurate quantification of anti-aging compound oleoylethanolamine in C. elegans. Anal Methods-UK 10, 2551-59

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Hisham Bazzi

  • Xiao C, Nitsche F, Bazzi H (2018). Visualizing the node and notochordal plate in gastrulating mouse embryos using scanning electron microscopy and whole mount immunofluorescence. J Vis Exp. 2018 Nov 6;(141). doi: 10.3791/58321

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Thomas Benzing

  • Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC (2018). Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Exp. Mol. Med. 2018 Jun 28;50(6):75. doi:10.1038/s12276-018-0108-z                                                                                                                                                                         
  • Grundmann F, Müller RU, Reppenhorst A, Hülswitt L, Späth MR, Kubacki T, Scherner M, Faust M, Becker I, Wahlers T, Schermer B, Benzing T, Burst V (2018). Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial. J Am Heart Assoc. 2018 Mar13;7(6).pii:e008181. doi: 10.1161/ JAHA.117.008181                                                                                                                                                                                        
  • Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT (2018). Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. FASEB J. 2018 Jan;32(1):208-219. doi: 10.1096/fj.201700309R. Epub 2017 Sep 6        
  • Höhne M, Frese CK, Grahammer F; Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM (2018). Single-nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int. 2018 Jun;93(6):1308-1319. doi: 10.1016/j.kint.2017.12.012. Epub 2018 Mar 9     
  • Karaiskos N, Rahmatollahi M, Boltengagen A, Liu H, Hoehne M, Rinschen M, Schermer B, Benzing T, Rajewsky N, Kocks C, Kann M, Müller RU (2018). A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. J Am Soc Nephrol. 2018 Aug;29(8):2060-2068. doi: 10.1681/ASN.2018030238. Epub 2018 May 24            
  • Meyer AM, Becker I, Siri G, Brinkkötter PT, Benzing T, Pilotto A, Polidori MC (2018). New associations of the Multidimensional Prognostic Index. Z Gerontol Geriatr. 2018 Nov 7. doi: 10.1007/s00391-018-01471-6. [Epub ahead of print]  
  • Müller RU, Benzing T (2018). Cystic Kidney Diseases From the Adult Nephrologist’s Point of View. Front Pediatr. 2018 Mar 22;6:65. doi: 10.3389/fped.2018.00065. eCollection 2018        
  • Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB (2018). A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Cell Rep. 2018 May 22;23(8):2495-2508. doi: 10.1016/j.celrep.2018.04.059 
  • Röhrig G, Polidori MC, Rascher K, Schaller M, Benzing T, Gersdorff G von (2018). Burden of multimorbidity and outcome in ambulatory geriatric hemodialysis patients : Report from the QiN registry in Germany. Z Gerontol Geriatr. 2018 Jan;51(1):60-66. doi: 10.1007/s00391-016-1149-3. Epub 2016 Nov 10            
  • Schroeter CB, Koehler S, Kann M, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM (2018). Protein half-life determines expression of proteostatic networks in podocyte differentiation. FASEB J. 2018 Sep;32(9):4696-4713. doi: 10.1096/fj.201701307R. Epub 2018 Apr 25                     
  • Siedek F, Persigehl T, Mueller RU, Burst V, Benzing T, Maintz D, Haneder S (2018). Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T. MAGMA 2018 Jun;31(3):367-374. doi: 10.1007/s10334-017-0658-4. Epub 2017 Oct 23                         
  • Slaats GG, Braun F, Hoehne M, Frech LE, Blomberg L, Benzing T, Schermer B, Rinschen MM, Kurschat CE (2018). Urine-derived cells: a promising diagnostic tool in Fabry disease patients. Sci Rep. 2018 Jul 23;8(1):11042. doi: 10.1038/s41598-018-29240-w             
  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter, CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM (2018). The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. 2018 Nov 29. pii: S0085-2538(18)30644-6. doi: 10.1016/j.kint.2018.08.037. [Epub ahead of print]           
  • Völker LA, Maar BA, Pulido Guevara BA, Bilkei-Gorzo A, Zimmer A, Brönneke H, Dafinger C, Bertsch S, Wagener JR, Schweizer H, Schermer B, Benzing T, Hoehne M (2018). Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents. Genes Brain Behav. 2018 Nov;17(8):e12516. doi: 10.1111/gbb.12516. Epub 2018 Sep 14         
  • Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A; Frommolt P, Niessen CM, Spiro J, Persigehl T, Witterheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K (2018). AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6. Epub 2018 Jan 11                
  • Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT (2018). Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. FASEB J. 2018 Jan;32(1):208-219. doi: 10.1096/fj.201700309R. Epub 2017 Sep 6

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Matteo Bergami

  • Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T (2018). Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2018 Nov 2. pii: e9288. doi: 10.15252/emmm.201809288             
  • Schmidt E, Dhaouadi I, Gaziano I, Oliverio M, Klemm P, Awazawa M, Mitterer G, Fernandez-Rebollo E, Pradas-Juni M, Wagner W, Hammerschmidt P, Loureiro R, Kiefer C, Hansmeier NR, Khani S, Bergami M, Heine M, Ntini E, Frommolt P, Zentis P, Ørom UA, Heeren J, Blüher M, Bilban M, Kornfeld JW (2018). LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat. Nat Commun. 2018 Sep 6;9(1):3622. doi: 10.1038/s41467-018-05933-8 

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Andreas Beyer

  • Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM. (2018) Single nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int. 2018 Jun;93(6):1308-1319. doi: 10.1016/j.kint.2017.12.012. Epub 2018 Mar 9                 
  • Guo T, Li L, Zhong Q. Rupp NJ, Charmpi K, Wong CE, Wagner U, Rueschoff JH, Jochum W, Fankhauser CD, Saba K, Poyet C, Wild PJ, Aebersold R, Beyer A (2018). Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers. Life Sci Alliance. 2018 May 29;1(2). pii: e201800042. doi: 10.26508/lsa.201800042                  
  • Hahn O, Stubbs TM, Reik W, Grönke S, Beyer A, Partridge L (2018). Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity. PLoS Genet. 2018 Nov 21;14(11):e1007766. doi: 10.1371/journal.pgen.1007766. eCollection 2018 Nov
  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU#, Rinschen MM#. (2018) The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. 95(2):333-349. doi: 10.1016/j.kint.2018.08.037.        

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Jens Brüning

  • Mittenbühler MJ, Sprenger HG, Gruber S, Wunderlich CM, Kern L, Brüning JC, Wunderlich FT (2018). Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma. Mol Metab. Nov;17: 122-133.
  • Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC (2018). Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep. Oct 9; 25(2):382-397
  • Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT Munder AC, Simonds SE, Brüning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T (2018). Insulin regulates POMC neuronal plasticity to control glucose metabolism. Elife. Sept 19;7.
  • Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, Garcia-Caderes C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevilla ME, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg, P, Sabio G, Nogueiras R (2018). p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nat Commun. Aug 24; 9(1):3432.
  • Jiang H, Brüning JC (2018). Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters. Cell Metab. 2018 Jul 3;28(1):7-8.
  • Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC (2018). Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Exp Mol Med. Jun 28;50(6):75.
  • Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Brüning JC, Hammerschmidt M (2018). Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit. Cell Rep. May 8;23(6):1728-1741.
  • Dodd GT, Lee-Young RS, Brüning JC, Tiganis T (2018). TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding. Diabetes Jul;67(7):1246-1257.
  • Zhou J, WanJ, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Quian SB (2018). N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response. Mol Cell. Feb 15;69(4):636-647
  • Schüler R, Seebeck N, Osterhoff MA, Witte V, Flöel A, Busjahn A, Jais A, Brüning JC, Frahnow T, Kabisch S, Pivovarova O, Hornemann S, Kruse M, Pfeiffer AFH (2018). VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans. Mol Metab. 2018 May;11:129-136. doi: 10.1016/j.molmet.2018.02.004. Epub 2018 Feb 12            
  • Brandt C, Nolte H, Henschke S, Engström Ruud L, Awazawa M, Morgan DA, Gabel P, Sprenger HG, Hess ME, Günther S, Langer T, Rahmouni K, Fenselau H, Krüger M, Brüning JC (2018). Food Perception Primes Hepatic ER-Homeostasis via Melanocortin-Dependent Control of mTOR-Activation. Cell. Nov 15; 175(5):1321-1335          

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Oliver Cornely

  • Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Bruning JC, Tittgemeyer M. Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metab 2018.
  • Oladele RO, Osaigbovo, II, Ayanlowo OO, Otu AA, Hoenigl M, Cornely OA, Chakrabarti A, Denning DW. The role of medical mycology societies in combating invasive fungal infections in low- and middle-income countries: A Nigerian model. Mycoses 2018.
  • Mellinghoff SC, von Bergwelt-Baildon M, Schosser HA, Cornely OA. A novel approach to candidemia? The potential role of checkpoint inhibition. Med Mycol 2018.
  • Bassetti M, Righi E, Montravers P, Cornely OA (2018). What has changed in the treatment of invasive candidiasis? A look at the past 10 years and ahead. Mycoses. 2018;73(suppl_1):i14-i25 
  • Gavino C, Mellinghoff S, Cornely OA (2018). Novel bi-allelic splice mutations in CARD9 causing adult-onset Candida endophthalmitis. Mycoses. 2018;61(1):61-5    
  • Mellinghoff SC, Vehreschild JJ, Liss B, Cornely OA (2018). Epidemiology of Surgical Site Infections With Staphylococcus aureus in Europe: Protocol for a Retrospective, Multicenter Study. JMIR Res Protoc. 2018 Mar 12;7(3):e63
  • Mellinghoff SC, Panse J, Alakel N, Behre G, Buchheidt D, Christopeit M, Hasenkamp J, Kiehl M, Koldehoff M, Krause SW, Lehners N, von Lilienfeld-Toal M, Lohnert AY, Maschmeyer G, Teschner D, Ullmann AJ, Penack O, Ruhnke M, Mayer K, Ostermann H, Wolf HH, Cornely OA (2018). Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO). Ann Hematol. 2018;97(2):197-207
  • Mellinghoff SC, Hoenigl M, Koehler P, Kumar A, Lagrou K, Lass-Flörl C, Meis JF, Menon V, Rautemaa-Richardson R1, Cornely OA (2018). EQUAL Candida Score: An ECMM score derived from current guidelines to measure QUAlity of Clinical Candidaemia Management. Mycoses. 2018 Jan 11. [Epub ahead of print]
  • Mellinghoff SC, Bassetti M, Dorfel D, Hagel S, Lehners N, Plis A, Schalk E, Vena A, Cornely OA (2018). Isavuconazole shortens the QTc interval. Mycoses. 2018;61(4):256-60
  • Springer J, White PL, Kessel J, Wieters I, Teschner D, Korczynski D, Liebregts T, Cornely OA, Schwartz S, Elgeti T, Meintker L, Krause SW, Posso RB, Heinz WJ, Fuhrmann S, Vehreschild JJ, Einsele H, Rickerts V, Loeffler JA (2018). Comparison of Aspergillus and Mucorales PCR Testing of Different Bronchoalveolar Lavage Fluid Fractions from Patients with Suspected Invasive Pulmonary Fungal Disease. J Clin Microbiol. 2018 Jan 24;56(2)                    
  • Baldin C, Soliman SSM, Jeon HH, Alkhazraji S, Gebremariam T, Gu Y, Bruno VM, Cornely OA, Leather HL, Sugrue MW, Wingard JR, Stevens DA, Edwards JE, Jr., Ibrahim AS (2018). PCR-based approach targeting Mucorales specific gene family for the diagnosis of mucormycosis. J Clin Microbiol. 2018 Sep 25;56(10). pii: e00746-18. doi: 10.1128/JCM.00746-18. Print 2018 Oct       
  • Basu A, Prabhu VS, Dorr MB, Golan Y, Dubberke ER, Cornely OA, Heimann SM, Pedley A, Xu R, Hanson ME, Marcella S (2018). Bezlotoxumab Is Associated With a Reduction in Cumulative Inpatient-Days: Analysis of the Hospitalization Data From the MODIFY I and II Clinical Trials. Open Forum Infect Dis. 2018 Nov 15;5(11):ofy218. doi: 10.1093/ofid/ofy218. eCollection 2018 Nov   
  • Bloos F, Held J, Schlattmann P, Brillinger N, Kurzai O, Cornely OA, Thomas-Ruddel D (2018). (1,3)-beta-D-glucan-based diagnosis of invasive Candida infection versus culture-based diagnosis in patients with sepsis and with an increased risk of invasive Candida infection (CandiSep): study protocol for a randomized controlled trial. Trials 2018 Sep 4;19(1):472. doi: 10.1186/s13063-018-2868-0         
  • Cornely OA, Koehler P, Arenz D, Mellinghof SC (2018). EQUAL Aspergillosis Score 2018: An ECMM score derived from current guidelines to measure QUALity of the clinical management of invasive pulmonary aspergillosis. Mycoses  2018 Nov;61(11):833-836. doi: 10.1111/myc.12820. Epub 2018 Jul 13                   
  • Cornely OA, Kontoyiannis DP (2018). How to prophylax against invasive fungal infections in adult ALL? An unmet need. Mycoses 2018 Apr 25. doi: 10.1111/myc.12786. [Epub ahead of print]                      
  • Cornely OA, Mullane KM, Ostrosky-Zeichner L, Maher RM, Croos-Dabrera R, Lu QY, Lademacher C, Perfect JR, Oren I, Schmitt-Hoffmann AH, Giladi M, Marty FM, Rahav G (2018). Isavuconazole for treatment of rare invasive fungal diseases. Mycoses 2018 Aug;61(8):518-533. doi: 10.1111/myc.12778                        
  • Cornely OA, Watt M, McCrea C, Goldenberg SD, De Nigris E (2018). Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients aged >/=60 years (EXTEND): analysis of cost-effectiveness. J Antimicrob Chemother. 2018 Sep 1;73(9):2529-2539. doi: 10.1093/jac/dky184                           
  • Farowski F, Bucker V, Vehreschild JJ, Biehl L, Cruz-Aguilar R, Scheid C, Holtick U, Jazmati N, Wisplinghoff H, Cornely OA, Vehreschild M (2018). Impact of choice, timing, sequence and combination of broad-spectrum antibiotics on the outcome of allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant.2018 Jan;53(1):52-57. doi: 10.1038/bmt.2017.203. Epub 2017 Nov 13                  
  • Gastine S, Lehrnbecher T, Muller C, Farowski F, Bader P, Ullmann-Moskovits J, Cornely OA, Groll AH, Hempel G (2018). Pharmacokinetic Modeling of Voriconazole To Develop an Alternative Dosing Regimen in Children. Antimicrob Agents Ch. 2018.; 62(1): 13               
  • Guery B, Menichetti F, Anttila VJ, Adomakoh N, Aguado JM, Bisnauthsing K, Georgopali A, Goldenberg SD, Karas A, Kazeem G, Longshaw C, Palacios-Fabrega JA, Cornely OA, Vehreschild M, Grp ECS (2018). Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial. Lancet Infect Dis. 2018 Mar;18(3):296-307. doi: 10.1016/S1473-3099(17)30751-X. Epub 2017 Dec 19                      
  • Hamprecht AG, Martin R, Mellinghoff SC, Walther G, Cornely OA, Kurzai O (2018). Candida auris in Germany - report of the first clinical cases of an emerging nosocomial pathogen. Med Mycol. 2018; 56: S32-S                
  • Heimann SM, Biehl LM, Vehreschild JJ, Franke B, Cornely OA, Vehreschild M (2018). Chlorhexidine-containing dressings in the prevention of central venous catheter-related bloodstream infections: A cost and resource utilization analysis. Am J Infect Control. 2018 Sep;46(9):992-997. doi: 10.1016/j.ajic.2018.03.006. Epub 2018 Apr 13                    
  • Heimann SM, Vehreschild M, Cornely OA, Heinz WJ, Gruner B, Silling G, Kessel J, Seidel D, Vehreschild JJ (2018). Healthcare Burden of Probable and Proven Invasive Mucormycosis: A Multicenter Cost-of-Illness Analysis of Patients Treated in Tertiary Care Hospitals between 2003 - 2016. J Hosp Infect. 2018 Nov 10. pii: S0195-6701(18)30589-9. doi: 10.1016/j.jhin.2018.11.003. [Epub ahead of print]                      
  • Hoenigl M, Gangneux JP, Segal E, Alanio A, Chakrabarti A, Chen SC, Govender N, Hagen F, Klimko N, Meis JF, Pasqualotto AC, Seidel D, Walsh TJ, Lagrou K, Lass-Florl C, Cornely OA (2018). Global Guidelines and Initiatives from the European Confederation of Medical Mycology to improve Patient Care and Research Worldwide: New Leadership is about Working Together. Mycoses 2018 Nov;61(11):885-894. doi: 10.1111/myc.12836. Epub 2018 Aug 28                       
  • Jenks JD, Reed SL, Seidel D, Koehler P, Cornely OA, Mehta SR, Hoenigl M (2018). Rare Mold Infections Caused by Mucorales, Lomentospora Prolificans and Fusarium, San Diego: The Role of Antifungal Combination Therapy. Int J Antimicrob Agents. 2018 Nov;52(5):706-712. doi: 10.1016/j.ijantimicag.2018.08.005. Epub 2018 Aug 9                         
  • Koehler FC, Cornely OA, Wisplinghoff H, Chang DH, Richter A, Koehler P (2018). Candida-reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine. Mycoses 2018 Jan;61(1):48-52. doi: 10.1111/myc.12696. Epub 2017 Sep 26                        
  • Koehler FC, Cornely OA, Wisplinghoff H, Schauss AC, Salmanton-Garcia J, Ostermann H, Ziegler M, Bacher P, Scheffold A, Alex R, Richter A, Koehler P (2018). Candida-Reactive T Cells for the Diagnosis of Invasive Candida Infection-A Prospective Pilot Study. Front Microbiol. 2018 Jun 22;9:1381. doi: 10.3389/fmicb.2018.01381. eCollection 2018      
  • Kontoyiannis DP, Selleslag D, Mullane K, Cornely OA, Hope W, Lortholary O, Croos-Dabrera R, Lademacher C, Engelhardt M, Patterson TF (2018). Impact of unresolved neutropenia in patients with neutropenia and invasive aspergillosis: a post hoc analysis of the SECURE trial. J Antimicrob Chemother. 2018; 73(3): 757-63                      
  • Maertens J, Selleslag D, Heinz WJ, Saulay M, Rahav G, Giladi M, Aoun M, Kovanda L, Kaufhold A, Engelhardt M, Cornely OA, Herbrecht R, Ullmann AJ (2018). Treatment outcomes in patients with proven/probable vs possible invasive mould disease in a phase III trial comparing isavuconazole vs voriconazole. Mycoses 2018 Nov;61(11):868-876. doi: 10.1111/myc.12831. Epub 2018 Aug 13                      
  • Maertens JA, Girmenia C, Bruggemann RJ, Duarte RF, Kibbler CC, Ljungman P, Racil Z, Ribaud P, Slavin MA, Cornely OA, Peter Donnelly J, Cordonnier C (2018). European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia. J Antimicrob Chemother. 2018 Dec  1;73(12):3221-3230. doi: 10.1093/jac/dky286                 
  • Marty FM, Cornely OA, Mullane KM, Ostrosky-Zeichner L, Maher RM, Croos-Dabrera R, Lu QY, Lademacher C, Oren I, Schmitt-Hoffmann AH, Giladi M, Rahav G, Perfect JR (2018). Isavuconazole for treatment of invasive fungal diseases caused by more than one fungal species. Mycoses 2018 Jul;61(7):485-497. doi: 10.1111/myc.12777. Epub 2018 Apr 26                
  • Mellinghoff SC, Hartmann P, Cornely FB, Knauth L, Kohler F, Kohler P, Krause C, Kronenberg C, Kranz SL, Menon V, Muller H, Naendrup JH, Putzfeld S, Ronge A, Rutz J, Seidel D, Wisplinghoff H, Cornely OA (2018). Analyzing candidemia guideline adherence identifies opportunities for antifungal stewardship. Eur J Clin Microbiol Infect Dis. 2018 Aug;37(8):1563-1571. doi: 10.1007/s10096-018-3285-8. Epub 2018 Jun 13                          
  • Mellinghoff SC, Kohler P, Seidel D, Cornely OA (2018). Mucormycosis in patients with diabetes mellitus. Diabetologe 2018; 14(3): 153-9            
  • Perfect JR, Cornely OA, Heep M, Ostrosky-Zeichner L, Mullane KM, Maher R, Croos-Dabrera R, Lademacher C, Engelhardt M, Chen C, Marty FM (2018). Isavuconazole treatment for rare fungal diseases and for invasive aspergillosis in patients with renal impairment: Challenges and lessons of the VITAL trial. Mycoses  2018; 61(7): 420-9                
  • Postina P, Skladny J, Boch T, Cornely OA, Hamprecht A, Rath PM, Steinmann J, Bader O, Miethke T, Dietz A, Merker N, Hofmann WK, Buchheidt D, Spiess B (2018). Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients. Front Microbiol. 2018 Mar 27;9:555. doi: 10.3389/fmicb.2018.00555. eCollection 2018                  
  • Rieger CT, Liss B, Mellinghoff S, Buchheidt D, Cornely OA, Egerer G, Heinz WJ, Hentrich M, Maschmeyer G, Mayer K, Sandherr M, Silling G, Ullmann A, Vehreschild M, von Lilienfeld-Toal M, Wolf HH, Lehners N (2018). Anti-infective Vaccination Strategies in Patients with Hematologic Malignancies or Solid Tumors - Guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO). Ann Oncol. 2018 Jun 1;29(6):1354-1365. doi: 10.1093/annonc/mdy117                 
  • Salzer HJF, Burchard G, Cornely OA, Lange C, Rolling T, Schmiedel S, Libman M, Capone D, Le T, Dalcolmo MP, Heyckendorf J (2018). Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease. Respiration 2018;96(3):283-301. doi: 10.1159/000489501. Epub 2018 Jun 28       
  • Schmidt-Hieber M, Bierwirth J, Buchheidt D, Cornely OA, Hentrich M, Maschmeyer G, Schalk E, Vehreschild JJ, Vehreschild M, Grp AW (2018). Diagnosis and management of gastrointestinal complications in adult cancer patients: 2017 updated evidence-based guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol. 2018 Jan;97(1):31-49. doi: 10.1007/s00277-017-3183-7. Epub 2017 Nov 24              
  • Spec A, Mejia-Chew C, Powderly WG, Cornely OA (2018). EQUAL Cryptococcus Score 2018: A European Confederation of Medical Mycology Score Derived From Current Guidelines to Measure QUALity of Clinical Cryptococcosis Management. Open Forum Infect Dis. 2018 Nov 12;5(11):ofy299. doi: 10.1093/ofid/ofy299. eCollection 2018 Nov             
  • Springer J, McCormick Smith I, Hartmann S, Winkelmann R, Wilmes D, Cornely OA, Kessel J, Loffler J, Rickerts V (2018). Identification of Aspergillus and Mucorales in formalin-fixed, paraffin-embedded tissue samples: Comparison of specific and broad-range fungal qPCR assays. Med Mycol. 2018 Jun 19. doi: 10.1093/mmy/myy041. [Epub ahead of print]         
  • Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Florl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Bruggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Loffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinko J, Skiada A, Vehreschild M, Viscoli C, Cornely OA (2018). Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect. 2018 May;24 Suppl 1:e1-e38. doi: 10.1016/j.cmi.2018.01.002. Epub 2018 Mar 12               
  • Winston DJ, Mullane KM, Cornely OA, Boeckh MJ, Brown JW, Pergam SA, Trociukas I, Zak P, Craig MD, Papanicolaou GA, Velez JD, Panse J, Hurtado K, Fernsler DA, Stek JE, Pang L, Su SC, Zhao YL, Chan ISF, Kaplan SS, Parrino J, Lee I, Popmihajlov Z, Annunziato PW, Arvin A, Team VPT (2018). Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2018 May 26;391(10135):2116-2127. doi: 10.1016/S0140-6736(18)30631-7. Epub 2018 May 24                  
  • Wunderink RG, Giamarellos-Bourboulis EJ, Rahav G, Mathers AJ, Bassetti M, Vazquez J, Cornely OA, Solomkin J, Bhowmick T, Bishara J, Daikos GL, Felton T, Furst MJL, Kwak EJ, Menichetti F, Oren I, Alexander EL, Griffith D, Lomovskaya O, Loutit J, Zhang S, Dudley MN, Kaye KS (2018). Effect and Safety of Meropenem-Vaborbactam versus Best-Available Therapy in Patients with Carbapenem-Resistant Enterobacteriaceae Infections: The TANGO II Randomized Clinical Trial. Infect Dis Ther.2018 Dec;7(4):439-455. doi: 10.1007/s40121-018-0214-1. Epub 2018 Oct 1   
  • Zoran T, Sartori B, Sappl L, Aigner M, Sanchez-Reus F, Rezusta A, Chowdhary A, Taj-Aldeen SJ, Arendrup MC, Oliveri S, Kontoyiannis DP, Alastruey-Izquierdo A, Lagrou K, Lo Cascio G, Meis JF, Buzina W, Farina C, Drogari-Apiranthitou M, Grancini A, Tortorano AM, Willinger B, Hamprecht A, Johnson E, Klingspor L, Arsic-Arsenijevic V, Cornely OA, Meletiadis J, Prammer W, Tullio V, Vehreschild JJ, Trovato L, Lewis RE, Segal E, Rath PM, Hamal P, Rodriguez-Iglesias M, Roilides E, Arikan-Akdagli S, Chakrabarti A, Colombo AL, Fernandez MS, Martin-Gomez MT, Badali H, Petrikkos G, Klimko N, Heimann SM, Uzun O, Roudbary M, de la Fuente S, Houbraken J, Risslegger B, Lass-Florl C, Lackner M (2018). Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon? Front Microbiol. 2018 Mar 28;9:516. doi: 10.3389/fmicb.2018.00516. eCollection 2018            

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Martin Denzel

  • Horn M, Kroef V, Allmeroth K, Schuller N, Miethe S, Peifer M, Penninger JM, Elling U, Denzel MS (2018).Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells. Oncotarget. 2018 Jan 23;9(11): 98389851. doi:10.18632/oncotarget.24305. eCollection 2018 Feb 9      
  • Pichlo C, Toelzer C, Chojnacki K, Öcal S, Uthoff M, Ruegenberg S, Hermanns T, Schacherl M, Denzel MS, Hofmann K, Niefind K, Baumann U (2018). Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer. Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):307-314. doi: 10.1107/S2053230X18005253. Epub 2018 Apr 24         
  • Sawarkar R, Scherz-Shouval R, Denzel M, Saarikangas J (2018). Preparing junior faculty for success. Science. 2018 Jul 20;361(6399):238. doi: 10.1126/science.aau4531 
  • Denzel MS, Lapierre LR, Mack HID (2018). Emerging topics in C. elegans aging research: Transcriptional regulation, stress response, and epigenetics. Mech Ageing Dev. 2018 Aug 19. pii: S0047-6374(18)30083-6. doi: 10.1016/j.mad.2018.08.001. [Epub ahead of print]

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Sabine Eming

  • Willenborg S, Eming SA (2018). Cellular networks in wound healing. Science. Nov 23;362(6417): 891-892.
  • Mikosiński J, Kotala M, Stücker M, Twardowska-Saucha K, Bonnekoh B, Pańczak K, Aleksiejew-Kleszczyński T, Dissemond J, Eming SA, Kaspar D, Rousseau A, Bewert J, Schröder W, Smola H (2018). Clinical assessment of a foam dressing containing growth factor-enhancing hydrated polyurethanes. J Wound Care. Sep 2;27(9):608-618.
  • Eming SA (2018). Current pathophysiological developments in fibrosing diseases: insights into novel treatment concepts. Hautarzt. Nov; 69(11): 885-891.
  • Do NN, Willenborg S, Eckes B, Jüngst C, Sengle G, Zaucke F, Eming SA (2018). Myeloid Cell-Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program. J Immunol. Jul 15;201(2):663-674.
  • Ghouse SM, Polikarpova A, Muhandes L, Dudeck J, Tantcheva-Poór I, Hartmann K, Lesche M, Dahl A, Eming SA, Müller W, Behrendt R, Roers A (2018). Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors. Cell Rep. Jan 2; 22(1):27-35.
  • Nürnberg C, Kociok N, Brockmann C, Lischke T, Crespo-Garcia S, Reichhart N, Wolf S, Baumgrass R, Eming SA, Beer-Hammer S, Joussen AM (2018). Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells. Exp Eye Res. Jan;166:56-69.

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Mafalda Escobar-Henriques

  • N Shai, Yifrach E , van Roermund CWT , Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M, Zalckvar E (2018). Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact, Nat commun.  9(1) 1761.
  • Simões T, Schuster R, den Brave F, Escobar-Henriques M (2018). “Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion”,Elife. Jan 8 e30015.

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Henning Fenselau

  • Brandt C, Nolte H, Henschke S, Engström Ruud L, Awazawa M, Morgan DA, Gabel P, Sprenger HG, Hess ME, Günther S, Langer T, Rahmouni K, Fenselau H, Krüger M, Brüning JC. Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation. Cell. 2018 Nov 15;175(5):1321-1335.e20. doi: 10.1016/j.cell.2018.10.015. PMID: 30445039
  • Todd WD, Fenselau H, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB. A hypothalamic circuit for the circadian control of aggression. Nat Neurosci. 2018 May;21(5):717-724. doi: 10.1038/s41593-018-0126-0. Epub 2018 Apr 9. PMID: 29632359

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Martin Graef

  • Medeiros TC, Thomas RL, Ghillebert R, Graef M (2018). Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation.
    J Cell Biol. 2018 Mar 8. pii: jcb.201801168. doi: 10.1083/jcb.201801168. [Epub ahead of print] 
  • Graef M (2018). Lipid droplet-mediated lipid and protein homeostasis in budding yeast.(Review) FEBS Lett. 2018 Feb 3. doi: 10.1002/1873-3468.12996. [Epub ahead of print]
  • Graef M (2018). Membrane tethering by the autophagy ATG2A-WIPI4 complex. Proc. Natl. Acad. Sci.115, 10540-10541

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Matthias Hammerschmidt

  • Pogoda HM, Riedl-Quinkertz I, Löhr H, Waxman JS, Dale RM, Topczewski J, Schulte-Merker S, Hammerschmidt M (2018). Direct activation of chordoblasts by retinoic acid is required for segmented centra formation during zebrafish spine development. Development. 2018 May 8;145(9). pii: dev159418. doi: 10.1242/dev.159418    
  • Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold L, Schenkel C, Wunderlich CM, Kloppenburg P, Brüning JC, Hammerschmidt M (2018). Diet-induced growth is regulated via acquired leptin resistance and engages a Pomc-Somatostatin-Growth hormone circuitry. Cell Rep. 23,1728-1741          
  • McMillan SC, Zhang J, Phan HE, Jeradi S, Probst L, Hammerschmidt M, Akimenko MA (2018). A regulatory pathway involving retinoic acid and demarcates and maintains joint cells and osteoblasts in the fin regenerate. Development 145, dev.161158             
  • Janzen E, Mendoza-Ferreira N, Hosseinibarkooie S, Schneider S, Hupperich K, Tschanz T, Grysko V, Riessland M, Hammerschmidt M, Rigo F, Bennett CF, Kye MJ, Torres-Benito L, Wirth B (2018). CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity and endocytosis. Brain 141(8):2343-2361     
  • van der Ven AT, Kobbe B, Kohl S, Shril S, Pogoda HM, Imhof T, Ityel H, Vivante A, Chen J, Hwang DY, Connaughton DM, Mann N, Widmeier E, Taglienti M, Schmidt JM, Nakayama M, Senguttuvan P, Kumar S, Tasic V, Kehinde EO, Mane SM, Lifton RP, Soliman N, Lu W, Bauer SB, Hammerschmidt M, Wagener R, Hildebrandt FA (2018). Homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux. PLoS One. 13, e0191224           
  • Mendoza-Ferreira N, Coutelier M, Janzen E, Hosseinibarkooie S, Löhr H, Schneider S, Milbradt J, Karakaya M, Riessland M, Pichlo C, Torres-Benito L, Singleton A, Zuchner S, Brice A, Durr A, Hammerschmidt M, Stevanin G, Wirth B (2018). Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function. Neurol Genet. 4, e209

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Marco Herling

  • Andersson EI, Pützer S, Yadav B, Dufva O, Khan S, He L, Sellner L, Schrader A, Crispatzu G, Oleś M, Zhang H, Adnan S, Lagström S, Bellanger D, Mpindi JP, Eldfors S, Pemovska T, Pietarinen P, Lauhio A, Tomska K, Cuesta-Mateos C, Faber E, Koschmieder S, Brümmendorf TH, Kytölä S, Savolainen ER, Siitonen T, Ellonen P, Kallioniemi O, Wennerberg K, Ding W, Stern MH, Huber W, Anders S, Tang J, Aittokallio T, Zenz T, Herling M, Mustjoki S (2018). Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling. Leukemia 2018 Mar;32(3):774-787; IF 2016/17: 11.702
  • Dietrich S, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T (2018). Drug-perturbation-based stratification of blood cancer.J Clin Invest. 2018 Jan 2;128(1):427-445; IF 2016/17: 12.784
  • Schrader A, Crispatzu G, Oberbeck S, Mayer P, Pützer S, von Jan J, Vasyutina E, Warner K, Weit N, Pflug N, Braun T, Andersson EI, Yadav B, Riabinska A, Maurer B, Ventura Ferreira MS, Beier F, Altmüller J, Lanasa M, Herling CD, Haferlach T, Stilgenbauer S, Hopfinger G, Peifer M, Brümmendorf TH, Nürnberg P, Elenitoba-Johnson KSJ, Zha S, Hallek M, Moriggl R, Reinhardt HC, Stern MH, Mustjoki S, Newrzela S, Frommolt P, Herling M (2018). Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL. Nat Commun 2018 Feb 15;9(1):697. doi: 10.1038/s41467-017-02688-6; IF 2016/17: 12.124                                   
  • Pflug N, Cramer P, Robrecht S, Bahlo J, Westermann A, Fink AM, Schrader A, Mayer P, Oberbeck S, Seiler T, Zenz T, Dürig J, Kreuzer KA, Stilgenbauer S, Eichhorst B, Hallek M, Herling M, Hopfinger G (2018). New lessons learned in T-PLL - results from a prospective phase-II trial with fludarabine-mitoxantrone-cyclophosphamide-alemtuzumab induction followed by alemtuzumab maintenance. Leukemia Lymphoma. 2018 Sep 20:1-9, doi: 10.1080/10428194.2018.1488253. [Epub ahead of print]                          
  • Kotrova M, Novakova M, Oberbeck S, Mayer P, Schrader S, Knecht H, Hrusak O, Herling M, Brüggemann M (2018). Next-generation amplicon TRB locus sequencing can overcome limitations of flow-cytometric Vβ expression analysis and confirms clonality in all T-cell prolymphocytic leukemia cases. Cytometry A. 2018 Nov 10, doi: 10.1002/cyto.a.23604. Epub 2018 Nov 10

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Jan H.J. Hoeijmakers

  • Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD. Nuclear Genomic Instability and Aging. Annu Rev Biochem. 2018 Jun 20;87:295-322. doi: 10.1146/annurev-biochem-062917-012239. PMID: 29925262
  • Milanese C, Cerri S, Ulusoy A, Gornati SV, Plat A, Gabriels S, Blandini F, Di Monte DA, Hoeijmakers JH, Mastroberardino PG. Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease. Cell Death Dis. 2018 Jul 26;9(8):818. doi: 10.1038/s41419-018-0848-7. PMID: 30050065
  • Mandemaker IK, Geijer ME, Kik I, Bezstarosti K, Rijkers E, Raams A, Janssens RC, Lans H, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA. DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones. EMBO Rep. 2018 Aug 13. pii: e45566. doi: 10.15252/embr.201745566. [Epub ahead of print] PMID: 30104204
  • Ribeiro-Silva C, Aydin ÖZ, Mesquita-Ribeiro R, Slyskova J, Helfricht A, Marteijn JA, Hoeijmakers JHJ, Lans H, Vermeulen W. DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1. Nat Commun. 2018 Oct 4;9(1):4067. doi: 10.1038/s41467-018-06402-y. PMID: 30287812

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Thorsten Hoppe

  • Balaji V, Pokrzywa W, Hoppe T (2018). Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis. Bioessays.2018 May;40(5):e1700223. doi: 10.1002/bies.201700223. Epub 2018 Apr 3
  • Franz A, Hoppe T (2018). Stressed Out: Mitohormesis Is Crossing Borders. Trends Endocrinol Metab. 2018 Aug;29(8):525-527. doi: 10.1016/j.tem.2018.03.007. Epub 2018 Mar 28
  • Höhfeld J, Hoppe T (2018). Ub and Down: Ubiquitin Exercise for the Elderly. Trends Cell Biol. 2018 Jul;28(7):512-522. doi: 10.1016/j.tcb.2018.03.002. Epub 2018 Apr 25                      
  • Dreher LS, Hoppe T (2018). ERADicate Tumor Progression with Metformin. Mol Cell. 2018 Aug 16;71(4):481-482. doi: 10.1016/j.molcel.2018.08.001             
  • Koyuncu S, Saez I, Lee HJ, Gutierrez-Garcia R, Pokrzywa W, Fatima A, Hoppe T, Vilchez D (2018). The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat Commun. 2018 Jul 23;9(1):2886. doi: 10.1038/s41467-018-05320-3
  • Dreher LS, Hoppe T (2018). Hepatic ERAD takes control of the organism. EMBO J. 2018 Nov 15;37(22). pii: e100676. doi: 10.15252/embj.2018100676. Epub 2018 Nov 2

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Tamas Horvath

  • Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, Arque G, Tasan RO, Sperk G, Malenczyk K, Máté Z, Erdélyi F, Szabó G, Lubec G, Palkovits M, Giordano A, Hökfelt TG, Romanov RA, Horvath TL, Harkany T: Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress. EMBO J. 2018 Nov 2; 2018 Sep 12. PMID: 30209240
  • Tebbenkamp ATN, Varela L, Choi J, Paredes MI, Giani AM, Song JE, Sestan-Pesa M, Franjic D, Sousa AMM, Liu ZW, Li M, Bichsel C, Koch M, Szigeti-Buck K, Liu F, Li Z, Kawasawa YI, Paspalas CD, Mineur YS, Prontera P, Merla G, Picciotto MR, Arnsten AFT, Horvath TL, Sestan N: The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell. 2018 Nov 1. PMID: 30318146
  • Diano S, Horvath TL, Mor G, Register T, Adams M, Harada N, Naftolin F: Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. Menopause. 2018 Nov. PMID: 30358714
  • Stoiljkovic M, Kelley C, Horvath TL, Hajós M: Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats. Alzheimers Res Ther. 2018 Oct 10; 2018 Oct 10. PMID: 30301466
  • Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC: Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep. 2018 Oct 9. PMID: 30304679
  • Rash BG, Micali N, Huttner AJ, Morozov YM, Horvath TL, Rakic P: Metabolic regulation and glucose sensitivity of cortical radial glial cells. Proc Natl Acad Sci U S A. 2018 Oct 2; 2018 Sep 17. PMID: 30224493
  • Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Brüning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T: Insulin regulates POMC neuronal plasticity to control glucose metabolism. Elife. 2018 Sep 19; 2018 Sep 19. PMID: 30230471
  • Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD: Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Rep. 2018 Jul 31. PMID: 30067966
  • Stoiljkovic M, Kelley C, Stutz B, Horvath TL, Hajós M: Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer's Disease Pathology. Cereb Cortex. 2018 Jun 16; 2018 Jun 16. PMID: 29920597
  • Mancini G, Horvath TL: Viral Vectors for Studying Brain Mechanisms that Control Energy Homeostasis. Cell Metab. 2018 Jun 5. PMID: 29874565
  • Kim KE, Jeong EA, Lee JY, Yi CO, Park KA, Jin Z, Lee JE, Horvath TL, Roh GS: Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochem Biophys Res Commun. 2018 May 23; 2018 Apr 10. PMID: 29634925
  • Kiss DS, Ioja E, Toth I, Barany Z, Jocsak G, Bartha T, Horvath TL, Zsarnovszky A: Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TRα) and Beta (TRβ) Expression in Rat Primary Cerebellar Cell Cultures. Int J Mol Sci. 2018 May 11; 2018 May 11. PMID: 29751674
  • Miletta MC, Horvath TL: Patient-Derived iPSC-Hypothamic Neurons: The Ultimate Protocol. Cell Stem Cell. 2018 May 3. PMID: 29727675
  • Singh AK, Aryal B, Chaube B, Rotllan N, Varela L, Horvath TL, Suárez Y, Fernández-Hernando C: Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis. Mol Metab. 2018 May; 2018 Mar 29. PMID: 29627378
  • Miletta MC, Horvath TL: From white to beige: a new hypothalamic pathway. EMBO Rep. 2018 Apr; 2018 Mar 26. PMID: 29581171
  • Varela L, Horvath TL: Neuronal Cilia: Another Player in the Melanocortin System. Trends Mol Med. 2018 Apr; 2018 Feb 28. PMID: 29501261
  • Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C: Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. JCI Insight. 2018 Mar 22; 2018 Mar 22. PMID: 29563332
  • Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A: Type I interferons instigate fetal demise after Zika virus infection. Sci Immunol. 2018 Jan 5. PMID: 29305462
  • Ralevski E, Shanabrough M, Newcomb J, Gandelman E, Hayden R, Horvath TL, Petrakis I: Ghrelin is Related to Personality Differences in Reward Sensitivity and Impulsivity. Alcohol Alcohol. 2018 Jan 1. PMID: 29136100

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Sandra Iden

  • Vorhagen S, Kleefisch D, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM, Iden S (2018). Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis. Oncogene. 2018 Sep;37(37):5136-5146. doi: 10.1038/s41388-018-0313-1. Epub 2018 May 23

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Frank Jessen

  • Rhodius-Meester HFM, Liedes H, Koikkalainen J, Wolfsgruber S, Coll-Padros N, Kornhuber J, Peters O, Jessen F, Kleineidam L, Molinuevo JL, Rami L, TeunissenCE, Barkhof F, Sikkes SAM, Wesselman LMP, Slot RER, Verfaillie SCJ, Scheltens P, Tijms BM, Lötjönen J, van der Flier WM. Computer-assisted prediction of clinical progression in the earliest stages of AD. Alzheimers Dement(Amst). 2018 Oct8;10:726-736. doi: 10.1016/j.dadm.2018.09.001. eCollection 2018. PubMed PMID:30619929; PubMed Central PMCID: PMC6310913.
  • Marchant NL, Barnhofer T, Klimecki OM, Poisnel G, Lutz A, Arenaza-Urquijo E, Collette F, Wirth M, Schild AK, Coll-Padrós N, Reyrolle L, Horney D, Krolak-Salmon P, Molinuevo JL, Walker Z, Maillard A, Frison E, Jessen F, ChételatG; SCD-WELL Medit-Ageing Research Group. The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education onmental health in patients with subjective cognitive decline (SCD). Alzheimers Dement (NY). 2018 Dec 14;4:737-745. doi: 10.1016/j.trci.2018.10.010. eCollection2018. PubMed PMID: 30581979; PubMed Central PMCID: PMC6296291.
  • Düzel E, Berron D, Schütze H, Cardenas-Blanco A, Metzger C, Betts M, Ziegler G, Chen Y, Dobisch L, Bittner D, Glanz W, Reuter M, Spottke A, Rudolph J,Brosseron F, Buerger K, Janowitz D, Fliessbach K, Heneka M, Laske C, Buchmann M, Nestor P, Peters O, Diesing D, Li S, Priller J, Spruth EJ, Altenstein S, Ramirez A, Schneider A, Kofler B, Speck O, Teipel S, Kilimann I, Dyrba M, Wiltfang J,Bartels C, Wolfsgruber S, Wagner M, Jessen F. CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. Alzheimers Dement (Amst). 2018 Nov 2;10:782-790. doi: 10.1016/j.dadm.2018.10.003. eCollection 2018. PubMed PMID: 30555890; PubMed Central PMCID: PMC6280588.
  • Slot RER, Sikkes SAM, Berkhof J, Brodaty H, Buckley R, Cavedo E, Dardiotis E,Guillo-Benarous F, Hampel H, Kochan NA, Lista S, Luck T, Maruff P, Molinuevo JL, Kornhuber J, Reisberg B, Riedel-Heller SG, Risacher SL, Roehr S, Sachdev PS, Scarmeas N, Scheltens P, Shulman MB, Saykin AJ, Verfaillie SCJ, Visser PJ, VosSJB, Wagner M, Wolfsgruber S, Jessen F. Alzheimer's Disease Neuroimaging Initiative, the DESCRIPA working group, the INSIGHT-preAD study group, on behalf of the SCD-I working group, van der Flier WM. Subjective cognitive decline andrates of incident Alzheimer's disease and non-Alzheimer's disease dementia. Alzheimers Dement. 2018 Dec 13. pii: S1552-5260(18)33563-5. doi:10.1016/j.jalz.2018.10.003. [Epub ahead of print] PubMed PMID: 30555032.
  • Scheef L, Grothe MJ, Koppara A, Daamen M, Boecker H, Biersack H, Schild HH, Wagner M, Teipel S, Jessen F. Subregional volume reduction of the cholinergic forebrain in subjective cognitive decline (SCD). Neuroimage Clin. 2018 Nov 27:101612. doi: 10.1016/j.nicl.2018.101612. [Epub ahead of print] PubMed PMID: 30555006.
  • Espinosa A, Hernández-Olasagarre B, Moreno-Grau S, Kleineidam L, Heilmann-Heimbach S, Hernández I, Wolfsgruber S, Wagner H, Rosende-Roca M, Mauleón A, Vargas L, Lafuente A, Rodríguez-Gómez O, Abdelnour C, Gil S, Marquié M, Santos-Santos MA, Sanabria Á, Ortega G, Monté-Rubio G, Pérez A, Ibarria M, Ruiz S, Kornhuber J, Peters O, Frölich L, Hüll M, Wiltfang J, Luck T, Riedel-Heller S, Montrreal L, Cañabate P, Moreno M, Preckler S, Aguilera N, de Rojas I, Orellana A, Alegret M, Valero S, Nöthen MM, Wagner M, Jessen F, Tárraga L, Boada M, Ramírez A, Ruiz A. Exploring Genetic Associations of Alzheimer's Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes. Front Aging Neurosci. 2018 Oct 30;10:340. doi: 10.3389/fnagi.2018.00340. eCollection 2018. PubMed PMID: 30425636; PubMed Central PMCID: PMC6218590.
  • Peloso GM, van der Lee SJ; International Genomics of Alzheimer's Project (IGAP), Destefano AL, Seshardi S. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. Alzheimers Dement (Amst). 2018 Sep 22;10:595-598. doi: 10.1016/j.dadm.2018.08.008. eCollection 2018. PubMed PMID: 30422133; PubMed Central PMCID: PMC6215982.
  • Roehr S, Riedel-Heller SG, Kaduszkiewicz H, Wagner M, Fuchs A, van der Leeden C, Wiese B, Werle J, Bickel H, König HH, Wolfsgruber S, Pentzek M, Weeg D, Mamone S, Weyerer S, Brettschneider C, Maier W, Scherer M, Jessen F, Luck T. Is function in instrumental activities of daily living a useful feature in predicting Alzheimer's disease dementia in subjective cognitive decline? Int J Geriatr Psychiatry. 2019 Jan;34(1):193-203. doi: 10.1002/gps.5010. Epub 2018 Nov 9. PubMed PMID: 30353573.
  • Frisoni GB, Barkhof F, Altomare D, Berkhof J, Boccardi M, Canzoneri E, Collij L, Drzezga A, Farrar G, Garibotto V, Gismondi R, Gispert JD, Jessen F, Kivipelto M, Lopes Alves I, Molinuevo JL, Nordberg A, Payoux P, Ritchie C, Savicheva I, Scheltens P, Schmidt ME, Schott JM, Stephens A, van Berckel B, Vellas B, Walker Z, Raffa N. AMYPAD Diagnostic and Patient Management Study: Rationale and design. Alzheimers Dement. 2018 Oct 16. pii: S1552-5260(18)33528-3. doi: 10.1016/j.jalz.2018.09.003. [Epub ahead of print] PubMed PMID: 30339801.
  • Hu X, Teunissen CE, Spottke A, Heneka MT, Düzel E, Peters O, Li S, Priller J, Buerger K, Teipel S, Laske C, Verfaillie SCJ, Barkhof F, Coll-Padrós N, Rami L, Molinuevo JL, van der Flier WM, Jessen F. Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies. Alzheimers Dement. 2019 Feb;15(2):185-193. doi: 10.1016/j.jalz.2018.09.002. Epub 2018 Oct 12. PubMed PMID: 30321506.
  • Heser K, Pohontsch NJ, Scherer M, Löffler A, Luck T, Riedel-Heller SG, Maier  W, Parker D, Haenisch B, Jessen F. Perspective of elderly patients on chronic use of potentially inappropriate medication - Results of the qualitative CIM-TRIAD study. PLoS One. 2018 Sep 19;13(9):e0202068. doi: 10.1371/journal.pone.0202068. eCollection 2018. PubMed PMID: 30231027; PubMed Central PMCID: PMC6145513.
  • Pohontsch NJ, Löffler A, Luck T, Heser K, Parker D, Haenisch B, Riedel-Heller SG, Jessen F, Scherer M. Informal caregivers' perspectives on health of and (potentially inappropriate) medication for (relatively) independent oldest-old people - a qualitative interview study. BMC Geriatr. 2018 Jul 25;18(1):169. doi:  10.1186/s12877-018-0849-5. PubMed PMID: 30045689; PubMed Central PMCID: PMC6060533.
  • Fischer K, Melo van Lent D, Wolfsgruber S, Weinhold L, Kleineidam L, Bickel H, Scherer M, Eisele M, van den Bussche H, Wiese B, König HH, Weyerer S, Pentzek  M, Röhr S, Maier W, Jessen F, Schmid M, Riedel-Heller SG, Wagner M. Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly. Nutrients. 2018 Jun 29;10(7). pii: E852. doi: 10.3390/nu10070852. PubMed PMID: 29966314; PubMed Central PMCID: PMC6073331.
  • Jessen F, Rodriguez Née Then FS. Not all, but specific types of cognitive complaints predict decline to MCI. Neurology. 2018 Jul 24;91(4):153-154. doi: 10.1212/WNL.0000000000005872. Epub 2018 Jun 29. PubMed PMID: 29959258.
  • Wesselman LMP, Schild AK, Coll-Padros N, van der Borg WE, Meurs JHP, Hooghiemstra AM, Slot RER, Sannemann L, Rami L, Molinuevo JL, Bouwman FH, Jessen F, van der Flier WM, Sikkes SAM; Euro-SCD working group. Wishes and preferences for an online lifestyle program for brain health-A mixed methods study. Alzheimers Dement (NY). 2018 Apr 9;4:141-149. doi: 10.1016/j.trci.2018.03.003. eCollection 2018. PubMed PMID: 29955658; PubMed Central PMCID: PMC6021582.
  • Tscheuschler M, Gebest M, Jessen F, Drzezga A. The importance of molecular imaging (PET) in the diagnostics of dementia. Nervenarzt. 2018 Jul;89(7):843-856. doi: 10.1007/s00115-018-0533-1. German. PubMed PMID: 29916030.
  • Teipel SJ, Metzger CD, Brosseron F, Buerger K, Brueggen K, Catak C, Diesing D, Dobisch L, Fliebach K, Franke C, Heneka MT, Kilimann I, Kofler B, Menne F, Peters O, Polcher A, Priller J, Schneider A, Spottke A, Spruth EJ, Thelen M, Thyrian RJ, Wagner M, Düzel E, Jessen F, Dyrba M; DELCODE study group. Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease. J Alzheimers Dis. 2018;64(3):801-813. doi: 10.3233/JAD-180106. PubMed PMID: 29914027.
  • Mallon T, Ernst A, Brettschneider C, König HH, Luck T, Röhr S, Weyerer S, Werle J, Mösch E, Weeg D, Fuchs A, Pentzek M, Kleineidam L, Heser K, Riedel-Heller S, Maier W, Wiese B, Scherer M; AgeCoDe & AgeQualiDe study group. Prevalence of pain and its associated factors among the oldest-olds in different care settings - results of the AgeQualiDe study. BMC Fam Pract. 2018 Jun 9;19(1):85. doi: 10.1186/s12875-018-0768-8. PubMed PMID: 29885656; PubMed Central PMCID: PMC5994256.
  • Gaebel W, Jessen F, Kanba S. Neurocognitive disorders in ICD-11: the debate and its outcome. World Psychiatry. 2018 Jun;17(2):229-230. doi: 10.1002/wps.20534. PubMed PMID: 29856541; PubMed Central PMCID: PMC5980293.
  • Volhard T, Jessen F, Kleineidam L, Wolfsgruber S, Lanzerath D, Wagner M, Maier W. Advance directives for future dementia can be modified by a brief video  presentation on dementia care: An experimental study. PLoS One. 2018 May 24;13(5):e0197229. doi: 10.1371/journal.pone.0197229. eCollection 2018. PubMed PMID: 29795605; PubMed Central PMCID: PMC5967707.
  • Dafsari FS, Jessen F. Late life depression - Diagnosis, pathophysiology and therapeutic strategies. Fortschr Neurol Psychiatr. 2018 Apr;86(4):242-255. doi:  10.1055/s-0043-119799. Epub 2018 Apr 24. Review. German. PubMed PMID: 29689582.
  • Strupp J, Hanke G, Schippel N, Pfaff H, Karbach U, Rietz C, Voltz R, CoRe-Net. Last Year of Life Study Cologne (LYOL-C): protocol for a cross-sectional mixed methods study to examine care trajectories and transitions in the last year of life until death. BMJ Open. 2018 Apr 17;8(4):e021211. doi:10.1136/bmjopen-2017-021211. PubMed PMID: 29666139; PubMed Central PMCID:PMC5905737.
  • Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R, Contributors. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018. Review. PubMed PMID: 29653606; PubMed Central PMCID: PMC5958625.
  • Jessen F, Frölich L. ICD-11: Neurocognitive Disorders. Fortschr Neurol Psychiatr. 2018 Mar;86(3):172-177. doi: 10.1055/s-0044-101607. Epub 2018 Apr 5. Review. German. PubMed PMID: 29621819.
  • Frisoni GB, Jessen F. One step towards dementia prevention. Lancet Neurol. 2018 Apr;17(4):294-295. doi: 10.1016/S1474-4422(18)30086-3. Epub 2018 Feb 27. PubMed PMID: 29500155.
  • Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, MacCabe JH, McCarroll SA, Baune BT, Breen G, Byrne EM, Dannlowski U, Eley TC, Hayward C, Martin NG, McIntosh AM, Plomin R, Porteous DJ,  Wray NR, Caballero A, Geschwind DH, Huckins LM, Ruderfer DM, Santiago E, Sklar P, Stahl EA, Won H, Agerbo E, Als TD, Andreassen OA, Bækvad-Hansen M, Mortensen PB,  Pedersen CB, Børglum AD, Bybjerg-Grauholm J, Djurovic S, Durmishi N, Pedersen MG, Golimbet V, Grove J, Hougaard DM, Mattheisen M, Molden E, Mors O, Nordentoft M, Pejovic-Milovancevic M, Sigurdsson E, Silagadze T, Hansen CS, Stefansson K, Stefansson H, Steinberg S, Tosato S, Werge T; GERAD1 Consortium:; CRESTAR Consortium:, Collier DA, Rujescu D, Kirov G, Owen MJ, O'Donovan MC, Walters JTR;  GERAD1 Consortium; CRESTAR Consortium; GERAD1 Consortium; CRESTAR Consortium. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet. 2018 Mar;50(3):381-389. doi: 10.1038/s41588-018-0059-2. Epub 2018 Feb 26. PubMed PMID: 29483656; PubMed Central PMCID: PMC5918692.
  • Brosseron F, Traschütz A, Widmann CN, Kummer MP, Tacik P, Santarelli F, Jessen F, Heneka MT. Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease. Alzheimers Res Ther.  2018 Feb 26;10(1):25. doi: 10.1186/s13195-018-0353-3. PubMed PMID: 29482610; PubMed Central PMCID: PMC5828084.
  • Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain. 2018 Apr 1;141(4):1186-1200. doi: 10.1093/brain/awy008. PubMed PMID: 29462334; PubMed Central PMCID: PMC5888938.
  • Berron D, Neumann K, Maass A, Schütze H, Fliessbach K, Kiven V, Jessen F, Sauvage M, Kumaran D, Düzel E. Age-related functional changes in domain-specific  medial temporal lobe pathways. Neurobiol Aging. 2018 May;65:86-97. doi: 10.1016/j.neurobiolaging.2017.12.030. Epub 2018 Jan 31. PubMed PMID: 29454154.
  • Schroeter ML, Pawelke S, Bisenius S, Kynast J, Schuemberg K, Polyakova M, Anderl-Straub S, Danek A, Fassbender K, Jahn H, Jessen F, Kornhuber J, Lauer M, Prudlo J, Schneider A, Uttner I, Thöne-Otto A, Otto M, Diehl-Schmid J. A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests. Front Aging Neurosci. 2018 Jan 30;10:11. doi: 10.3389/fnagi.2018.00011. eCollection 2018. PubMed PMID: 29441012; PubMed Central PMCID: PMC5797534.
  • Jessen F, Spottke A, Boecker H, Brosseron F, Buerger K, Catak C, Fliessbach K, Franke C, Fuentes M, Heneka MT, Janowitz D, Kilimann I, Laske C, Menne F, Nestor P, Peters O, Priller J, Pross V, Ramirez A, Schneider A, Speck O, Spruth EJ, Teipel S, Vukovich R, Westerteicher C, Wiltfang J, Wolfsgruber S, Wagner M, Düzel E. Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE). Alzheimers Res Ther. 2018 Feb 7;10(1):15. doi: 10.1186/s13195-017-0314-2. PubMed PMID: 29415768; PubMed Central PMCID: PMC5802096.
  • Miebach L, Wolfsgruber S, Frommann I, Fließbach K, Jessen F, Buckley R, Wagner M. Cognitive Complaints in Memory Clinic Patients and in Depressive Patients: An Interpretative Phenomenological Analysis. Gerontologist. 2018 Jan 8. doi: 10.1093/geront/gnx208. [Epub ahead of print] PubMed PMID: 29325011.
  • Hoenig MC, Bischof GN, Seemiller J, Hammes J, Kukolja J, Onur ÖA, Jessen F, Fliessbach K, Neumaier B, Fink GR, van Eimeren T, Drzezga A. Networks of tau distribution in Alzheimer's disease. Brain. 2018 Feb 1;141(2):568-581. doi: 10.1093/brain/awx353. PubMed PMID: 29315361.
  • Karbach U, Ansmann L, Scholten N, Pfaff H; für die CoRe-Net Antragssteller, Albus C, Jessen F, Kuntz L, Rietz C, Schubert I, Schulz-Nieswandt F, Stock S, Strupp J, Voltz R. Report from an ongoing research project: The Cologne Research and Development Network (CoRe-Net) and the value-based approach to healthcare. Z Evid Fortbild Qual Gesundhwes. 2018 Feb;130:21-26. doi: 10.1016/j.zefq.2017.11.005. Epub 2017 Dec 19. German. PubMed PMID: 29269171.
  • Lewczuk P, Riederer P, O'Bryant SE, Verbeek MM, Dubois B, Visser PJ, Jellinger KA, Engelborghs S, Ramirez A, Parnetti L, Jack CR Jr, Teunissen CE, Hampel H, Lleó A, Jessen F, Glodzik L, de Leon MJ, Fagan AM, Molinuevo JL, Jansen WJ, Winblad B, Shaw LM, Andreasson U, Otto M, Mollenhauer B, Wiltfang J, Turner MR, Zerr I, Handels R, Thompson AG, Johansson G, Ermann N, Trojanowski JQ, Karaca I, Wagner H, Oeckl P, van Waalwijk van Doorn L, Bjerke M, Kapogiannis D, Kuiperij HB, Farotti L, Li Y, Gordon BA, Epelbaum S, Vos SJB, Klijn CJM, Van Nostrand WE,  Minguillon C, Schmitz M, Gallo C, Lopez Mato A, Thibaut F, Lista S, Alcolea D, Zetterberg H, Blennow K, Kornhuber J; Members of the WFSBP Task Force Working on  this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut. Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. World J Biol Psychiatry. 2018 Jun;19(4):244-328. doi: 10.1080/15622975.2017.1375556. Epub 2017 Oct 27. Review. PubMed PMID: 29076399; PubMed Central PMCID: PMC5916324.

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Hamid Kashkar

  • Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V (2018). BAX/BAK induced apoptosis results in caspase-8 dependent IL-1b maturation in primary macrophages. Cell Rep. 2018 Nov 27;25(9):2354-2368.e5. doi: 10.1016/j.celrep.2018.10.087             
  • Schiffmann LM, Fritsch M, Gebauer F, Günther SD, Stair NR, Seeger JM, Thangarajah F, Dieplinger G, Bludau M, Alakus H, Göbel H, Quaas A, Zander T, Hilberg F, Bruns CJ, Kashkar H, Coutelle O (2018). Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer. Br J Cancer. 2019 Jan;120(1):69-78. doi: 10.1038/s41416-018-0198-3. Epub 2018 Oct 31          
  • Habich M, Salscheider S, Murschall L, Hoehne M, Fischer M, Schorn F, Petrungaro C, Ali M, Erdogan A, Abou-Eid S, Kashkar H, Dengjel J, Riemer J (2018). Vectorial import via a metastable disulphide-linked complex allows for a quality control step and efficient import by the mitochondrial disulphide relay Cell Rep. [accepted]

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Peter Kloppenburg

  • Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik J.A, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC (2018). Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep. Oct 9; 25(2):383-397       
  • Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-ebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R (2018). p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nat Commun. 2018 Aug 24;9(1):3432. doi: 10.1038/s41467-018-05711-6                 
  • Neupert S, Fusca D, Kloppenburg P, Predel R (2018). Analysis of single neurons by perforated patch clamp recordings and MALDI-TOF mass spectrometry. ACS Chem Neurosci. 2018 Aug 15;9(8):2089-2096. doi: 10.1021/acschemneuro.8b00163. Epub 2018 Jul 3     
  • Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Brüning JC, Hammerschmidt M (2018). Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit. Cell Rep. 2018 May 8;23(6):1728-1741. doi: 10.1016/j.celrep.2018.04.018                     
  • Nawrot MP, Kloppenburg P, Deger M (2018). Foreword for the special issue on Neural Coding. Biol Cybern. 112(1), 11

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Natalia Kononenko

  • Gonçalves IdCG, Brecht J, Thelen MP, Rehorst WA, Peters M, Lee HJ, Motameny S, Torres-Benito L, Ebrahimi-Fakhari D, Kononenko NL, Altmüller J, Vilchez D, Sahin M, Wirth B, Kye MJ. Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Sci Rep. May 21;8(1):7907 (2018).
  • Yan X, Kononenko NL, Brüel A, Skovhus Thomsen J, Poy MN. Neuronal cell adhesion molecule 1 regulates leptin sensitivity and bone mass. Calcif Tissue Int. Mar;102:329-336 (2018).

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Tatiana Korotkova

  • Ponomarenko A, Korotkova T. Hunger is a gatekeeper of pain in the brain. News and views for Alhadeff et, Cell 2018. Nature, 556(7702):445-446.
  • Bender F,  Korotkova, T,  Ponomarenko, A. Optogenetic control of hippocampal theta oscillations in behaving mice (2018).  J Vis Exp.29 (136). doi: 10.3791/57349.
  • Carus-Cadavieco M, Gorbati M, Ye L, Bender F, van der Veldt S, Kosse C, Börgers C, Lee SY, Ramakrishnan C, Hu Y, Denisova N, Ramm F, Volitaki E, Burdakov D, Deisseroth K, Ponomarenko A, Korotkova T (2017). Gamma oscillations organize top-down signaling to hypothalamus and enable food seeking. Nature, 542(7640):232-236. IF 40.1; 15 cit.
  • Korotkova T*, Ponomarenko A, Monaghan CK, Poulter SL, Cacucci F, Wills T, Hasselmo ME, Lever C*(2018). Reconciling the different faces of hippocampal theta: the role of theta oscillations in cognitive, emotional and innate behaviors. Neuroscience & Biobehavioral Reviews, 85: 65-80. (* - corresponding author). IF 8.3; 3 cit.

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Martin Krönke

  • Blissenbach B, Nakas CT, Krönke M, Geiser T, Merz TM, Pichler Hefti J (2018). Hypoxia-induced changes in plasma micro-RNAs correlate with pulmonary artery pressure at high altitude. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L157-L164
  • Gluschko A, Herb M, Wiegmann K, Krut O, Neiss WF, Utermöhlen O, Krönke M, Schramm M (2018). The β2 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes. Cell Host Microbe. 2018 Mar 14;23(3):324-337.e5. doi: 10.1016/j.chom.2018.01.018                         
  • Herb M, Gluschko A, Wiegmann K, Farid A, Wolf A, Utermöhlen O, Krut O, Krönke M, Schramm M (2018). Mitochondrial reactive oxygen species regulate pro-inflammatory signaling vie disulfide linkage of NEMO. Sci Signal. in press

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Marcus Krüger

  • Neumann P, Jaé N, Knau A, Glaser SF, Fouani Y, Rossbach O, Krüger M, John D, Bindereif A, Grote P, Boon RA, Dimmeler S (2018). The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2. Nat Commun. 9(1), 237.
  • Rabiee A, Krüger M, Ardenkjær-Larsen J, Kahn CR, Emanuelli B (2018). Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. Cell Signal. 47, 1-15.
  • Wiederstein JL, Nolte H, Günther S, Piller T, Baraldo M, Kostin S, Bloch W, Schindler N, Sandri M, Blaauw B, Braun T, Hölper S, Krüger M (2018). Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Reports 23(5), 1342-56.
  • Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M (2018). Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. BBA-MOL BASIS DIS. 1864(5 Pt A), 1816-27.
  • Lang F, Khaghani S, Türk C, Wiederstein JL, Hölper S, Piller T, Nogara L, Blaauw B, Günther S, Müller S, Braun T, Krüger M (2018). Single muscle fiber proteomics reveals distinct protein changes in slow and fast fibers during muscle atrophy. JPR 17(10):3333-3347.
  • Brandt C, Nolte H, Henschke S,Engtröm Ruud L, Awazawa M, Morgan DA,Gabel P, Sprenger HG, Hess M, Günter S,  Langer T, Rahmouni, Krüger M, Brüning JC (2018). Sensory Food Perception Rapidly Primes Postprandial ER-Homeostasis through Melanorcortin-Dependent Control of Liver mTOR Activation. Cell 175(5):1321-1335
  • Nolte H, MacVicar TD, Tellkamp F, Krüger M (2018). Instant Clue: A Software Suite for Interactive Data Visualization and Analysis. Sci Rep. 8(1), 12648

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Leo Kurian

  • Bartsch D, Zirkel A, Kurian L (2018). Characterization of Circular RNAs (circRNA) Associated with the Translation Machinery. Methods Mol Biol. 2018;1724:159-166. doi: 10.1007/978-1-4939-7562-4_13
  • Mondal T, Juvvuna PK, Kirkeby A, Mitra S, Kosalai ST, Traxler L, Hertwig F, Wernig-Zorc S, Miranda C, Deland L, Volland R, Bartenhagen C, Bartsch D, Bandaru S, Engesser A, Subhash S, Martinsson T, Carén H, Akyürek LM, Kurian L, Kanduri M, Huarte M, Kogner P, Fischer M, Kanduri C (2018) Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis. Cancer Cell. 2018 Mar 12;33(3):417-434.e7. doi: 10.1016/j.ccell.2018.01.020
  • Palanimurugan R, Gödderz D, Kurian L, Dohmen J (2018). Analysis of Cotranslational Polyamine Sensing During Decoding of ODC Antizyme mRNA. Methods Mol Biol. 2018;1694:309-323. doi: 10.1007/978-1-4939-7398-9_26          
  • Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling J, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L (2018). yylncT defines a class of divergently-transcribed lncRNAs and safeguards the T-mediated mesodermal commitment of human PSCs. Cell Stem Cell (Publication ahead of print)

Michael Lammers

  • Hansen BK, Gupta R, Baldus L, Lyon D, Narita T, Lammers M, Choudhary C, Weinert BT (2019). Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation. Nat. Commun. 2019 Mar 5;10(1):1055. doi: 10.1038/s41467-019-09024-0.
  • Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C (2018). DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor sensitivity. Cell. Doi: 10.1016/j.cell.2018.03.050. In press
  • Kremer M, Kuhlmann N, Lechner M, Baldus L, Lammers M (2018). Comment on ‘YcgC represents a new protein deacetylase family in prokaryotes'. eLife. 25;7. pii: e37798. doi: 10.7554/eLife.37798
  • Lammers M (2018). Expression and Purification of Site-Specifically Lysine-Acetylated  and Natively-Folded Proteins for Biophysical Investigations. Methods Mol Biol. 1728:169-190.

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Thomas Langer

  • Rashid T, Nemazanyy I, Paolini C, Tatsuta T, Crespin P, de Villeneuve D, Brodesser S, Benit P, Rustin P, A Baraibar M, Agbulut O, Olivier A, Protasi F, Langer T, Chrast R, de Lonlay P, de Foucauld H, Blaauw B, Pende M (2018). Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. Embo J. e99576, doi:10.15252#7embj.201899576.
  • Sprenger HS, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T (2018). Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol. Medicine, doi:10.15252/emmm. 201809288. Manuscript highlighted in EMBO Mol. Medicine.
  • Patron M, Sprenger HG, Langer T (2018). m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration. Cell Research 28:296-306.
  • Saita S, Tatsuta T, Lampe PA, König T, Ohba Y, Langer T (2018). PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria. EMBOJ (2018) 37: e97909       
  • Brandt C, Nolte H, Henschke S, Engtröm Ruud L, Awazawa M, Morgan DA, Gabel P, Sprenger HG, Hess M, Günter S, Langer T, Rahmouni K, Krüger M, Brüning JC (2018). Sensory food perception rapidly primes postprandial ER-homeostasis through Melanorcortin-dependent control of liver mTOR activation. Cell 15;175(5): 1321-1335. doi: 10.1016/j.cell.2018.10.015

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Nils-Göran Larsson

  • Bonekamp NA, Larsson NG (2018). SnapShot: Mitochondrial Nucleoid. Cell 2018 Jan 11;172(1-2):388-388.e1. doi: 10.1016/j.cell.2017.12.039

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Maria Leptin

  • Beati H, Peek I, Hordowska P, Honemann-Capito M, Glashauser J, Renschler F, Kakanj P, Ramrath A, Leptin M, Luschnig S, Wiesner S, Wodarz A (2018). The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. Journal of Cell Biology, 217, doi.org/10.1083/jcb.201610098

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Ivan Matic

  • Palazzo L, Leidecker O, Prokhorova E, Dauben H, Matic I, Ahel I (2018). Serine is the major residue for ADP-ribosylation upon DNA damage. Elife. 2018 Feb 26;7. pii: e34334. doi: 10.7554/eLife.34334 
  • Bartlett E, Bonfiglio JJ, Prokhorova E, Colby T, Zobel F, Ahel I, Matic I (2018). Interplay of Histone Marks with Serine ADP-Ribosylation. Cell Rep. 2018 Sep 25;24(13):3488-3502.e5. doi: 10.1016/j.celrep.2018.08.092

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Roman-Ulrich Müller

  • Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC (2018). Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Exp. Mol. Med. 50, 75 (2018).https://doi.org/10.1038/s12276-018-0108-z                  
  • Dal Magro C, Keller P, Kotter A, Werner S, Duarte V, Marchand V, Ignarski M, Freiwald A, Müller RU, Dieterich C, Motorin Y, Butter F, Atta M, Helm M (2018). A vastly increased chemical variety of RNA modifications that includes a thioacetal structure. Angew. Chem. Int. Ed. Engl. (2018) https://doi.org/10.1002/anie.201713188
  • Grundmann F, Müller RU, Reppenhorst A, Hülswitt L, Späth MR, Kubacki T, Scherner M, Faust M, Becker I, Wahlers T, Schermer B, Benzing T, Burst V (2018). Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial. J Am Heart Assoc. (2018) https://doi.org/10.1161/JAHA.117.008181      
  • Houbois C, Haneder S, Merkt M, Morelli JN, Schmidt M, Hellmich M, Mueller RU, Wahba R, Maintz D, Puesken M (2018). Can computed tomography volumetry of the renal cortex replace MAG3-scintigraphy in all patients for determining split renal function? Eur J Radiol. 103 (2018), 105–111. https://doi.org/10.1016/j.ejrad.2018.04.016          
  • Karaiskos N, Rahmatollahi M, Boltengagen A, Liu H, Hoehne M, Rinschen M, Schermer B, Benzing T, Rajewsky N, Kocks C, Kann M, Müller RU (2018). A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. J Am Soc Nephrol. (2018),https://doi.org/10.1681/ASN.2018030238         
  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM (2018). The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. (2018, accepted for publication)       
  • Müller RU, Benzing T (2018). Cystic Kidney Diseases From the Adult Nephrologist’s Point of View. Front Pediatr. 2018 Mar 22;6:65. doi: 10.3389/fped.2018.00065. eCollection 2018

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Carien Niessen

  • Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Kamprad N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA (2018). Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Nat Cell Biol. 2018 Jan;20(1):69-80. doi: 10.1038/s41556-017-0005-z
  • Urwyler-Rösselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M, Vandenabeele P, Declercq W (2018). Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation. J Invest Dermatol. 2018 Jan 6. pii: S0022-202X(18)30006-X. doi: 10.1016/j.jid.2017.12.031
  • Wickström SA, Niessen CM (2018). Cell adhesion and mechanics as drivers of tissue organization and differentiation: a question of local symmetry breaking. Curr Opin Cell Biol. Accepted
  • Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K (2018). AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene. 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6 
  • Vorhagen S, Kleefisch D, Persa, OD, Graband, A., SchwickertA, Saynisch M., LeitgesM, Niessen CM, IdenS (2018). Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis. Oncogene. 2018 Sep;37(37):5136-5146. doi: 10.1038/s41388-018-0313-1. Epub 2018 May 23         
  • Shafraz O, Rübsam M, Stahley SN, Caldara AL, Kowalczyk AP, Niessen CM, Sivasankar S (2018). E-cadherin binds to desmoglein to facilitate desmosome formation. Elife.Jul 12;7. pii: e37629. doi: 10.7554/eLife.37629         
  • Noethel B, Ramms L, Dreissen G, Springer R, Rübsam M, Ziegler WH, Niessen CM, Merkel R, Hoffmann B (2018). Transition of responsible mechanosensitive elements from focal adhesions to adherens junctions upon epithelial differentiation. Mol Biol Cell.  2018 Sep 15;29(19):2317-2325. doi: 10.1091/mbc.E17-06-0387. Epub 2018 Jul 25           
  • Olshausen G von, QuasdorfM, Bester R, Arzberger S, Ko C, van de Klundert M, Zhang K, Odenthal M, Ringelhan M, Niessen CM, Protzer U (2018). Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion. Oncotarget.Sep 21;9(74):33947-33960. doi: 10.18632/oncotarget.26103. eCollection 2018 Sep 21       
  • Ostermann AL, WunderlichCM, Schneiders L, Vogt MC, Woeste M, Belgardt, BF, NiessenCM, MartinyB, SchaussAC, SearsRC, KochPJ, BrüningJC, Wunderlich FT (2018). Intestinal insulin resistance compromises Dsc3 expression via FoxO1 nuclear retention that impairs epithelial integrity and promotes colon cancer. In revision

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Angelika Noegel

  • Braun DA, Lovric S, Schapiro D, Schneider R, Marquez J, Asif M, Hussain MS, Daga A, Widmeier E, Rao J, Ashraf S, Tan W, Lusk CP, Kolb A, Jobst-Schwan T, Schmidt JM, Hoogstraten CA, Eddy K, Kitzler TM, Shril S, Moawia A, Schrage K, Khayyat AIA, Lawson JA, Gee HY, Warejko JK, Hermle T, Majmundar AJ, Hugo H, Budde B, Motameny S, Altmüller J, Noegel AA, Fathy HM, Gale DP, Waseem SS, Khan A, Kerecuk L, Hashmi S, Mohebbi N, Ettenger R, Serdaroğlu E, Alhasan KA, Hashem M, Goncalves S, Ariceta G, Ubetagoyena M, Antonin W, Baig SM, Alkuraya FS, Shen Q, Xu H, Antignac C, Lifton RP, Mane S, Nürnberg P, Khokha MK, Hildebrandt F (2018). Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. J Clin Invest. Oct 1;128(10):4313-4328. doi: 10.1172/JCI98688           
  • Castagnino A, Castro-Castro A, Irondelle M, Guichard A, Lodillinsky C, Fuhrmann L, Vacher S, Agüera-González S, Zagryazhskaya-Masson A, Romao M, El Kesrouani C, Noegel AA, Dubois T, Raposo G, Bear JE, Clemen CS, Vincent-Salomon A, Bièche I, Chavrier P (2018). Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function. Oncogene. Jul 31. doi: 10.1038/s41388-018-0422-x            
  • Falk N, Kessler K, Schramm SF, Boldt K, Becirovic E, Michalakis S, Regus-Leidig H, Noegel AA, Ueffing M, Thiel CT, Roepman R, Brandstätter JH, Gießl A (2018). Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis. J Cell Sci. Aug 17;131(16). pii: jcs218487. doi: 10.1242/jcs.218487                
  • Karakesisoglou I, Mroß C, Noegel AA (2018). Functional Analysis of LINC Complexes in the Skin. Methods Mol Biol. 1840:295-306. doi: 10.1007/978-1-4939-8691-0_20           
  • Mroß C, Marko M, Munck M, Glöckner G, Motameny S, Altmüller J, Noegel AA, Eichinger L, Peche VS, Neumann S (2018). Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice. Nucleus. 9(1):503-515. doi: 10.1080/19491034.2018.1523664            
  • Müller R, Stumpf M, Wehrstedt R, Sukumaran SK, Karow MA, Marko M, Noegel AA, Eichinger L (2018). The regulatory subunit phr2AB of Dictyostelium discoideum phosphatase PP2A interacts with the centrosomal protein CEP161, a CDK5RAP2 ortholog. Genes Cells. Oct;23(10):923-931. doi: 10.1111/gtc.12637

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Peter Nürnberg

  • Alawbathani S, Kawalia A, Karakaya M, Altmuller J, Nurnberg P, Cirak S (2018). Late diagnosis of a truncating WISP3 mutation entails a severe phenotype of progressive pseudorheumatoid dysplasia. Cold Spring Harb Mol Case Stud. 4, a002139
  • Bobbili DR, Lal D, May P, Reinthaler EM, Jabbari K, Thiele H, Nothnagel M, Jurkowski W, Feucht M, Nurnberg P, Lerche H, Zimprich F, Krause R, Neubauer BA, Steinbock H, Neophytou B, Geldner J, Gruber-Sedlmayr U, Haberlandt E, Ronen GM, Altmuller J, Sander T, Balling R (2018). Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy. Eur J Hum Genet. 26, 258-264
  • Braun DA, Lovric S, Schapiro D, Schneider R, Marquez J, Asif M, Hussain MS, Daga A, Widmeier E, Rao J, Ashraf S, Tan W, Lusk CP, Kolb A, Jobst-Schwan T, Schmidt JM, Hoogstraten CA, Eddy K, Kitzler TM, Shril S, Moawia A, Schrage K, Khayyat AIA, Lawson JA, Gee HY, Warejko JK, Hermle T, Majmundar AJ, Hugo H, Budde B, Motameny S, Altmuller J, Noegel AA, Fathy HM, Gale DP, Waseem SS, Khan A, Kerecuk L, Hashmi S, Mohebbi N, Ettenger R, Serdaroglu E, Alhasan KA, Hashem M, Goncalves S, Ariceta G, Ubetagoyena M, Antonin W, Baig SM, Alkuraya FS, Shen Q, Xu H, Antignac C, Lifton RP, Mane S, Nurnberg, P, Khokha MK, Hildebrandt F (2018). Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. J Clin Invest. 128, 4313-4328
  • Broekaert IJ, Becker K, Gottschalk I, Korber F, Dotsch J, Thiele H, Altmuller J, Nurnberg P, Hunseler C, Cirak S (2018). Mutations in plasmalemma vesicle-associated protein cause severe syndromic protein-losing enteropathy. J Med Genet. 55, 637-640
  • Capecchi G, Baldassarri M, Ferranti S, Guidoni E, Cioni M, Nurnberg P, Mencarelli MA, Renieri A, Grosso S (2018). CKAP2L mutation confirms the diagnosis of Filippi syndrome. Clin Genet. 93, 1109-1110
  • Eisenberger T, Di Donato N, Decker C, Delle Vedove A, Neuhaus C, Nurnberg G, Toliat M, Nurnberg P, Murbe D, Bolz HJ (2018). A C-terminal nonsense mutation links PTPRQ with autosomal-dominant hearing loss, DFNA73. Genet Med. 20, 614-621
  • Fazeli W, Becker K, Herkenrath P, Duchting C, Korber F, Landgraf P, Nurnberg P, Altmuller J, Thiele H, Koy A, Liebau MC, Simon T, Dotsch J, Cirak S (2018). Dominant SCN2A Mutation Causes Familial Episodic Ataxia and Impairment of Speech Development. Neuropediatrics 49, 379-384
  • George J, Walter V, Peifer M, Alexandrov LB, Seidel D, Leenders F, Maas L, Muller C, Dahmen I, Delhomme TM, Ardin M, Leblay N, Byrnes G, Sun R, De Reynies A, McLeer-Florin A, Bosco G, Malchers F, Menon R, Altmuller J, Becker C, Nurnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soloway MG, Wilkerson MD, Cun Y, McKay JD, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Lemaitre N, Soltermann A, Weder W, Tischler V, Brustugun OT, Lund-Iversen M, Helland A, Solberg S, Ansen S, Wright G, Solomon B, Roz L, Pastorino U, Petersen I, Clement JH, Sanger J, Wolf J, Vingron M, Zander T, Perner S, Travis WD, Haas SA, Olivier M, Foll M, Buttner R, Hayes DN, Brambilla E, Fernandez-Cuesta L, Thomas RK (2018). Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. Nat Commun. 9, 1048
  • Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmuller J, Nurnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, Hagen JM van, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG (2018). Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet. 103, 431-439
  • Hauke J, Horvath J, Gross E, Gehrig A, Honisch E, Hackmann K, Schmidt G, Arnold N, Faust U, Sutter C, Hentschel J, Wang-Gohrke S, Smogavec M, Weber BHF, Weber-Lassalle N, Weber-Lassalle K, Borde J, Ernst C, Altmuller J, Volk AE, Thiele H, Hubbel V, Nurnberg P, Keupp K, Versmold B, Pohl E, Kubisch C, Grill S, Paul V, Herold N, Lichey N, Rhiem K, Ditsch N, Ruckert C, Wappenschmidt B, Auber B, Rump A, Niederacher D, Haaf T, Ramser J, Dworniczak B, Engel C, Meindl A, Schmutzler RK, Hahnen E (2018). Gene panel testing of 5589 BRCA1/2-negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer. Cancer Med. 7, 1349-1358
  • Herling CD, Abedpour N, Weiss J, Schmitt A, Jachimowicz RD, Merkel O, Cartolano M, Oberbeck S, Mayer P, Berg V, Thomalla D, Kutsch N, Stiefelhagen M, Cramer P, Wendtner CM, Persigehl T, Saleh A, Altmuller J, Nurnberg P, Pallasch C, Achter V, Lang U, Eichhorst B, Castiglione R, Schafer SC, Buttner R, Kreuzer KA, Reinhardt HC, Hallek M, Frenzel LP, Peifer M (2018). Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia. Nat Commun. 9, 727
  • Jabbari K, Bobbili DR, Lal D, Reinthaler EM, Schubert J,Wolking S, Sinha V, Motameny S, Thiele H, Kawalia A, Altmuller J, Toliat MR, Kraaij R, Rooij J van, Uitterlinden AG, Ikram MA, Zara F, Lehesjoki AE, Krause R, Zimprich F, Sander T, Neubauer BA, May P, Lerche H, Nurnberg P (2018). Rare gene deletions in genetic generalized and Rolandic epilepsies. PLoS ONE. 13, e0202022
  • Karakaya M, Storbeck M, Strathmann EA, Delle Vedove A, Holker I, Altmueller J, Naghiyeva, L, Schmitz-Steinkruger L, Vezyroglou K, Motameny S,Alawbathani S, Thiele H, Polat AI, Okur D, Boostani R, Karimiani EG, Wunderlich G, Ardicli D, Topaloglu H, Kirschner J, Schrank B, Maroofian R, Magnusson O, Yis U, Nurnberg P, Heller R, Wirth B (2018). Targeted sequencing with expanded gene profile enables high diagnostic yield in non-5q-spinal muscular atrophies. Hum Mutat. 39, 1284-1298
  • Khan AO, Budde BS, Nurnberg P, Kawalia A, Lenzner S, Bolz HJ (2018). Genome-wide linkage and sequence analysis challenge CCDC66 as a human retinal dystrophy candidate gene and support a distinct NMNAT1-related fundus phenotype. Clin Genet. 93, 149-154
  • Lessel D, Ozel AB, Campbell SE, Saadi A, Arlt MF, McSweeney KM, Plaiasu V, Szakszon K, Szollos A, Rusu C, Rojas AJ, Lopez-Valdez J, Thiele H, Nurnberg P, Nickerson DA, Bamshad MJ, Li JZ, Kubisch C, Glover TW, Gordon LB (2018). Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations. Hum Genet. 137, 921-939
  • Li M, Maljevic S, Phillips AM, Petrovski S, Hildebrand MS, Burgess R, Mount T, Zara F, Striano P, Schubert J, Thiele H, Nurnberg P, Wong M, Weisenberg JL, Thio LL, Lerche H, Scheffer IE, Berkovic SF, Petrou S, Reid CA (2018). Gain-of-function HCN2 variants in genetic epilepsy. Hum Mutat. 39, 202-209
  • Linnekamp JF, Hooff SRV, Prasetyanti PR, Kandimalla R, Buikhuisen JY, Fessler E, Ramesh P, Lee K, Bochove GGW, de Jong JH, Cameron K, Leersum RV, Rodermond HM, Franitza M, Nurnberg P, Mangiapane LR, Wang X, Clevers H, Vermeulen L, Stassi G, Medema JP (2018). Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models. Cell Death Differ. 25, 616-633
  • Maaser A, Forstner AJ, Strohmaier J, Hecker J, Ludwig KU, Sivalingam S, Streit F, Degenhardt F, Witt SH, Reinbold CS, Koller AC, Raff R, Heilmann-Heimbach S, Fischer SB, Herms S, Hoffmann P, Thiele H, Nurnberg P, Lohlein Fier H, Orozco-Diaz G, Carmenate-Naranjo D, Proenza-Barzaga N, Auburger GWJ, Andlauer TFM, Cichon S, Marcheco-Teruel B, Mors O, Rietschel M, Nothen MM (2018). Exome sequencing in large, multiplex bipolar disorder families from Cuba. PLoS ONE. 13, e0205895
  • Macheleidt IF, Dalvi PS, Lim SY, Meemboor S, Meder L, Kasgen O, Muller M, Kleemann K, Wang L, Nurnberg P, Russeler V, Schafer SC, Mahabir E, Buttner R, Odenthal M (2018). Preclinical studies reveal that LSD1 inhibition results in tumor growth arrest in lung adenocarcinoma independently of driver mutations. Mol Oncol. 12, 1965-1979
  • Martin CA, Sarlos K, Logan CV, Thakur RS, Parry DA, Bizard AH, Leitch A, Cleal L, Ali NS, Al-Owain MA, Allen W, Altmuller J, Aza-Carmona M, Barakat BAY, Barraza-Garcia J, Begtrup A, Bogliolo M, Cho MT, Cruz-Rojo J, Dhahrabi HAM, Elcioglu NH, Gorman GS, Jobling R, Kesterton I, Kishita Y, Kohda M, Le Quesne Stabej P, Malallah AJ, Nurnberg P, Ohtake A, Okazaki Y, Pujol R, Ramirez MJ, Revah-Politi A, Shimura M, Stevens P, Taylor RW, Turner L, Williams H, Wilson C, Yigit G, Zahavich L, Alkuraya FS, Surralles J, Iglesias A, Murayama K, Wollnik B, Dattani M, Heath KE, Hickson ID, Jackson AP (2018). Mutations in TOP3A Cause a Bloom Syndrome-like Disorder. Am J Hum Genet. 103, 221-231
  • May P, Girard S, Harrer M, Bobbili DR, Schubert J, Wolking S, Becker F, Lachance-Touchette, P, Meloche C, Gravel M, Niturad CE, Knaus J, De Kovel C, Toliat M, Polvi A, Iacomino M, Guerrero-Lopez R, Baulac S, Marini C, Thiele H, Altmuller J, Jabbari K, Ruppert AK, Jurkowski W, Lal D, Rusconi R, Cestele S, Terragni B, Coombs ID, Reid CA, Striano P, Caglayan H, Siren A, Everett K, Moller RS, Hjalgrim H, Muhle H, Helbig I, Kunz WS, Weber YG, Weckhuysen S, Jonghe P, Sisodiya SM, Nabbout R, Franceschetti S, Coppola A, Vari MS, Kasteleijn-Nolst Trenite D, Baykan B, Ozbek U, Bebek N, Klein KM, Rosenow F, Nguyen DK, Dubeau F, Carmant L, Lortie A, Desbiens R, Clement JF, Cieuta-Walti C, Sills GJ, Auce P, Francis B, Johnson MR, Marson AG, Berghuis B, Sander JW, Avbersek A, McCormack M, Cavalleri, G.L., Delanty, N., Depondt, C., Krenn, M., Zimprich, F., Peter, S., Nikanorova, M., Kraaij R, Rooij J van, Balling R, Ikram MA, Uitterlinden AG, Avanzini G, Schorge S, Petrou S,Mantegazza M, Sander T, LeGuern E, Serratosa JM, Koeleman BPC, Palotie A, Lehesjoki, AE, Nothnagel M, Nurnberg P, Maljevic S, Zara F, Cossette P, Krause R, Lerche H (2018). Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study. Lancet Neurol. 2018 Aug;17(8):699-708. doi: 10.1016/S1474-4422(18)30215-1. Epub 2018 Jul 17
  • Niestroj LM, Du J, Nothnagel M, May P, Palotie A, Daly MJ, Nurnberg P, Blumcke I, Lal D (2018). Guideline-based and bioinformatic reassessment of lesion-associated gene and variant pathogenicity in focal human epilepsies. Epilepsia 2018 Nov;59(11):2145-2152. doi: 10.1111/epi.14579. Epub 2018 Oct 20
  • Pauli S, Altmuller J, Schroder S, Ohlenbusch A, Dreha-Kulaczewski S, Bergmann C, Nurnberg P, Thiele H, Li Y, Wollnik B, Brockmann K (2018). Homozygosity for the c.428delG variant in KIAA0586 in a healthy individual: implications for molecular testing in patients with Joubert syndrome. J Med Genet. 2018;0:1–4. doi:10.1136/jmedgenet-2018-10547
  • Perez-Palma E, Saarentaus E, Ravoet M, De Ferrari GV, Nurnberg P, Isidor B, Neubauer BA, Lal D (2018). Duplications at 19q13.33 in patients with neurodevelopmental disorders. Neurol Genet. 4, e210. doi:10.1212/NXG.0000000000000210
  • Romano MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC (2018). Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex. Am J Hum Genet. 2018 Nov 1;103(5):777-785. doi: 10.1016/j.ajhg.2018.09.011. Epub 2018 Oct 25
  • Schrader A, Crispatzu G, Oberbeck S, Mayer P, Putzer S, Jan J von, Vasyutina E, Warner K, Weit N, Pflug N, Braun T, Andersson EI, Yadav B, Riabinska A, Maurer B, Ventura Ferreira MS, Beier F, Altmuller J, Lanasa M, Herling CD, Haferlach T, Stilgenbauer S, Hopfinger G, Peifer M, Brummendorf TH, Nurnberg P, Elenitoba-Johnson KSJ, Zha S, Hallek M, Moriggl R, Reinhardt HC, Stern MH, Mustjoki S, Newrzela S, Frommolt P, Herling M (2018). Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL. Nat Commun. 2018 Feb 15;9(1):697. doi: 10.1038/s41467-017-02688-6
  • Scicluna BP, Wiewel MA, Vught LA van, Hoogendijk AJ, Klarenbeek AM, Franitza M, Toliat, MR, Nurnberg P, Horn J, Bonten MJ, Schultz MJ, Cremer OL, van der Poll T (2018). Molecular Biomarker to Assist in Diagnosing Abdominal Sepsis upon ICU Admission. Am J Resp Crit Care. 2018 Apr 15;197(8):1070-1073. doi: 10.1164/rccm.201707-1339LE
  • Wagener R, Lopez C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altmuller J, Thiele H, Schneider C, Kolarova J, Park J, Hubschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, Nurnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, Wossmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, Kuppers R, Siebert R (2018). IG-MYC (+) neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas. Blood 2018 Nov 22;132(21):2280-2285. doi: 10.1182/blood-2018-03-842088. Epub 2018 Oct 3
  • Weber-Lassalle N, Hauke J, Ramser J, Richters L, Gross E, Blumcke B, Gehrig A, Kahlert AK, Muller CR, Hackmann K, Honisch E, Weber-Lassalle K, Niederacher D, Borde J, Thiele H, Ernst C, Altmuller J, Neidhardt G, Nurnberg P, Klaschik K, Schroeder C, Platzer K, Volk AE, Wang-Gohrke S, Just W, Auber B, Kubisch C, Schmidt G, Horvath J, Wappenschmidt B, Engel C; Arnold N, Dworniczak B, Rhiem K, Meindl A; Schmutzler RK, and Hahnen E (2018). BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer. Breast Cancer Res. 2018 Jan 24;20(1):7. doi: 10.1186/s13058-018-0935-9
  • Wenzel A, Altmueller J, Ekici AB, Popp B, Stueber K, Thiele H, Pannes A, Staubach S, Salido E, Nuernberg P, Reinhardt R, Reis A, Rump P, Hanisch FG, Wolf MTF, Wiesener M, Huettel, B, Beck BB (2018). Single molecule real time sequencing in ADTKD-MUC1 allows complete assembly of the VNTR and exact positioning of causative mutations. Sci Rep-UK 8, 4170.
  • Winterer G, Androsova G, Bender O, Boraschi D, Borchers F, Dschietzig TB, Feinkohl I, Fletcher P, Gallinat J, Hadzidiakos D, Haynes JD, Heppner F, Hetzer S, Hendrikse J, Ittermann B, Kant IMJ, Kraft A, Krannich A, Krause R; Kuhn S, Lachmann G, Montfort SJT van, Muller A, Nurnberg P, Ofosu K, Pietsch M, Pischon T, Preller J, Renzulli E; Scheurer K, Schneider R, Slooter AJC, Spies C, Stamatakis E; Volk HD, Weber S, Wolf A, Yurek F, Zacharias N (2018). Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project. Eur Psychiat. 2018 Apr;50:34-39. doi: 10.1016/j.eurpsy.2017.10.004. Epub 2018 Feb 3
  • Zirkel A, Nikolic M, Sofiadis K, Mallm JP, Brackley CA, Gothe H, Drechsel O, Becker C, Altmuller J, Josipovic N, Georgomanolis T, Brant L, Franzen J, Koker M,Gusmao EG, Costa IG, Ullrich RT, Wagner W, Roukos V, Nurnberg P, Marenduzzo D, Rippe K, Papantonis A (2018). HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. Mol Cell. 70, 730-744 e736

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Linda Partridge

  • Hahn O, Stubbs TM, Reik W, Grönke S, Beyer A, Partridge L (2018). Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity. PLoS Genet.2018 Nov 21;14(11):e1007766. doi: 10.1371/journal.pgen.1007766. eCollection 2018 Nov
  • Kauppila TES, Bratic A, Jensen MB, Baggio F, Partridge L, Jasper H, Grönke S,Larsson NG (2018). Mutations of mitochondrial DNA are not major contributors to aging of fruit flies. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9620-E9629. doi: 10.1073/pnas.1721683115. Epub 2018 Sep 24
  • Partridge L, Deelen J, Slagboom PE (2018). Facing up to the global challenges of ageing. Nature. 2018 Sep;561(7721):45-56. doi: 10.1038/s41586-018-0457-8. Epub 2018 Sep 5
  • Piper MDW, Partridge L (2018). Drosophila as a model for ageing. Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2707-2717. doi: 10.1016/j.bbadis.2017.09.016. Epub 2017 Sep 28
  • Flatt T, Partridge L (2018). Horizons in the evolution of aging. BMC Biol. 2018 Aug 20;16(1):93. doi: 10.1186/s12915-018-0562-z
  • Dönertas HM, Fuentealba Valenzuela M, Partridge L, Thornton JM (2018). Gene Expression-Based Drug Repurposing to Target Ageing. Aging Cell. 2018 Oct;17(5):e12819. doi: 10.1111/acel.12819. Epub 2018 Aug 9
  • Woodling NS, Partridge L (2018). Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button. Neuron.2018 Jun 27;98(6):1059-1061. doi: 10.1016/j.neuron.2018.06.025
  • Catterson JH, Khericha M, Dyson MC, Vincent AJ, Callard R, Haveron SM, Rajasingam A, Ahmad M, Partridge L (2018). Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension. Curr Biol. 2018 Jun 4;28(11):1714-1724.e4. doi: 10.1016/j.cub.2018.04.015. Epub 2018 May 17
  • Augustin H, McGourty K, Allen MJ, Adcott J, Wong CT, Boucrot E, Partridge L (2018). Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging. 2018 Jun;66:149-157. doi: 10.1016/j.neurobiolaging.2018.02.027. Epub 2018 Mar 6
  • Moens TG, Mizielinska S, Niccoli T, Mitchell JS, Thoeng A, Ridler CE, Grönke S, Esser J, Heslegrave A, Zetterberg H, Partridge L, Isaacs AM (2018). Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. Acta Neuropathol. 2018 Mar;135(3):445-457. doi: 10.1007/s00401-017-1798-3. Epub 2018 Jan 29
  • Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton El, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM (2018). G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. EMBO Mol Med. 2018 Jan;10(1):22-31. doi: 10.15252/emmm.201707850

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Manolis Pasparakis         

  • O'Donnell JA, Lehman J, Roderick JE, Martinez-Marin D, Zelic M, Doran C, Hermance N, Lyle S, Pasparakis M, Fitzgerald KA, Marshak-Rothstein A, Kelliher MA (2018). Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity. J Immunol. 2018 Jan 15;200(2):737-748. doi: 10.4049/jimmunol.1701229. Epub 2017 Dec 6   
  • Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23         
  • Armaka M, Ospelt C, Pasparakis M, Kollias G (2018). The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts. Nat Commun. 2018 Feb 12;9(1):618. doi: 10.1038/s41467-018-02935-4          
  • Androulidaki A, Wachsmuth L, Polykratis A, Pasparakis M (2018). Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes. PLoS One. 2018 Mar 9;13(3):e0194048. doi: 10.1371/journal.pone.0194048. eCollection 2018                     
  • O'Donnell JA, Lehman J, Roderick JE, Martinez-Marin D, Zelic M, Doran C, Hermance N, Lyle S, Pasparakis M, Fitzgerald KA, Marshak-Rothstein A, Kelliher MA (2018). Correction: Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity. J Immunol. 2018 Apr 15;200(8):3020-3021. doi: 10.4049/jimmunol.1800240. Epub 2018 Mar 12      
  • Vreka M, Lilis I, Papageorgopoulou M, Giotopoulou GA, Lianou M, Giopanou I, Kanellakis NI, Spella M, Agalioti T, Armenis V, Goldmann T, Marwitz S, Yull FE, Blackwell TS, Pasparakis M, Marazioti A, Stathopoulos GT (2018). IκB Kinase α Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma. Cancer Res. 2018 Jun 1;78(11):2939-2951. doi: 10.1158/0008-5472.CAN-17-1944. Epub 2018 Mar 27                  
  • Zelic M, Roderick JE, O'Donnell JA, Lehman J, Lim SE, Janardhan HP, Trivedi CM, Pasparakis M, Kelliher MA (2018). RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome. J Clin Invest. 2018 May 1;128(5):2064-2075. doi: 10.1172/JCI96147. Epub 2018 Apr 16              
  • Pasparakis M, Kelliher M (2018). Connecting immune deficiency and inflammation. Science. 2018 Aug 24;361(6404):756-757. doi: 10.1126/science.aau6962       
  • D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, Croker BA (2018). The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Sci Signal. 2018 Sep 4;11(546). pii: eaao1716. doi: 10.1126/scisignal.aao1716         
  • Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P (2018). ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25               
  • Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, Sarr A, Darding M, Draber P, Haas TL, Akarca A, Marafioti T, Pasparakis M, Bertin J, Gough PJ, Bouillet P, Strasser A, Leverkus M, Silke J, Walczak H (2018). LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L. Nat Commun. 2018 Sep 25;9(1):3910. doi: 10.1038/s41467-018-06155-8 
  • Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F, Vogel W, Klümper N, Nolte H, Wittersheim M, Tharun L, Castiglione R, Krüger M, Schauss A, Perner S, Pasparakis M, Büttner R, Persigehl T, Hucho T, Herter-Sprie GS, Schumacher B, Reinhardt HC (2018). The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Rep. 2018 Oct 23;25(4):1027-1039.e6. doi: 10.1016/j.celrep.2018.09.079

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Mats Paulsson

  • Chakkalakal S, Heilig J, Baumann U, Paulsson M, and Zaucke F (2018). Impact of arginine to cysteine mutations in collagen II on protein secretion and cell survival. Int. J. Mol. Sci., 19(2). pii: E541. doi: 10.3390/ijms 19020541
  • Lau D, Elezagic D, Hermes G, Mörgelin M, Wohl AP, Koch M, Hartmann U, Höllrieg S, Wagener R, Paulsson M, Streichert T, Klatt AR (2018). The cartilage-specific C-type lectin domain family 3 member A (CLEC3A) enhances tissue plasminogen activator-mediated plasminogen activation. J. Biol. Chem. 293, 203-214
  • Paulsson M, Wagener R (2018) Matrilins. Methods Cell Biol. 143, 329-446         
  • Karpati S, Sardy M, Nemeth K, Mayer B, Smyth N, Paulsson M, Traupe H (2018). Transglutaminases in autoimmune and inherited skin diseases: The phenomena of epitope spreading and functional compensation. Exp Dermatol. 27, 807-814

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Alvaro Rada-Iglesias

  • Fueyo R, Iacobucci S, Pappa S, Estarás C, Lois S, Vicioso-Mantis M, Navarro C, Cruz-Molina S, Reyes JC, Rada-Iglesias Á, de la Cruz X, Martínez-Balbás MA (2018). Lineage specific transcription factors and epigenetic regulators mediate TGFβ-dependent enhancer activation. Nucleic Acids Res. 2018 Apr 20;46(7):3351-3365. doi: 10.1093/nar/gky093
  • Rada-Iglesias A (2018). Is H3K4me1 at enhancers correlative or causative?. Nat Genet. 2018 Jan;50(1):4-5   
  • Rada-Iglesias A, Grosveld FG, Papantonis A (2018). Forces driving the three-dimensional folding of eukaryotic genomes. Mol Syst Biol. 2018 Jun 1;14(6):e8214. PMID: 29858282     
  • Rada-Iglesias A (2018). Pioneering of Enhancer Landscapes during Pluripotent State Transitions. Cell Stem Cell. 2018 Aug 2;23(2):149-151.PMID: 30075122          
  • Irmak D, Fatima A, Gutiérrez-Garcia R, Rinschen MM, Wagle P, Altmüller J, Arrigoni L, Hummel B, Klein C, Frese CK, Sawarkar R, Rada-Iglesias A, Vilchez D (2018). Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations. Hum Mol Genet. 2018 Dec 1;27(23):4117-4134. PMID: 30452683      
  • Laugsch M, Bartusel M, Alirzayeva H, Karaolidou A, Rehimi R, Crispatzu G, Nikolic M, Bleckwehl T, Kolovos P, van Ijcken, W.F.J., Šarić T, Köhler K, Frommolt P, Lachlan K,  Baptista J, Rada-Iglesias A (2018). Disruption of the TFAP2A Regulatory Domain Causes Branchio-Oculo-Facial Syndrome (BOFS) and Illuminates Pathomechanisms for Other Human Neurocristopathies. Preprint available at SSRN: ssrn.com/abstract=3155617. 2018. (Under Revision in Cell Stem Cell)

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Hans Christian Reinhardt

  • Jachimowicz RD, Beleggia F, Isensee J, Bhavana VB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y (2018). UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors. Cell. 2018 Dec 21. pii: S0092-8674(18)31516-2. doi: 10.1016/j.cell.2018.11.024
  • Castiglione R, Alidousty C, Holz B, Wagener S, Baar T, Heydt C, Binot E, Zupp S, Kron A, Wolf J, Merkelbach-Bruse S, Reinhardt HC, Büttner R, Schultheis AM (2018). Comparison of the genomic background of MET-altered carcinomas of the lung: biological differences and analogies. Modern Pathol.https://doi.org/10.1038/s41379-018-0182-8
  • Grimm C, Fischer A, Farrelly AM, Kalachand R, Castiglione R, Wasserburger E, Hussong M, Schultheis A, Altmüller J, Thiele H, Reinhardt HC, Hauschulz K, Hennessy BT, Herwig R, Lienhard M, Büttner R, Schweiger MR (2018). Combined targeted re-sequencing of cytosine DNA methylations and mutations for the determination of PARP1 inhibitor sensitivity. J Mol Diagn.accepted
  • Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N (2018). BRCA1/BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in C. elegans,EMBO Rep.2018 Oct 26. pii: e45856. doi: 10.15252/embr.201845856. [Epub ahead of print]
  • Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F, Vogel W, Klümper N, Nolte H, Wittersheim M, Tharun L, Castiglione R, Krüger M, Schauss A, Perner S, Pasparakis M, Büttner R, Persigehl T, Hucho T, Herter-Sprie GS, Schumacher B, Reinhardt HC (2018). The Cdkn1aSUPER mouse as a novel tool to study p53-mediated tumor suppression. Cell Rep. 2018 Oct 23;25(4):1027-1039.e6. doi: 10.1016/j.celrep.2018.09.079
  • Weber ANR, Gloria YC, Çınar Ö, Reinhardt HC, Pezzutto A, Wolz O-O (2018). Oncogenic MYD88 mutations in lymphoma – novel insights and therapeutic possibilities. Cancer Immunol Immunother.2018 Nov;67(11):1797-1807. doi: 10.1007/s00262-018-2242-9. Epub 2018 Sep 11
  • Schmitt A, Feldmann G, Zander T, Reinhardt HC (2018). Targeting defects in the cellular DNA damage response for the treatment of pancreatic ductal adenocarcinoma. Oncol Res Treat.2018;41(10):619-625. doi: 10.1159/000493401. Epub 2018 Sep 28
  • Fassunke J, Muller F, Keul M, Michels S, Dammert MA, Schmitt A, Plenker D, Lategahn J, Heydt C, Brägelmann J, Tumbrink HL, Alber Y, Klein S, Dahmen I, Fischer RN, Scheffler M, Ihle MA, Priesner V, Scheel AH, Wagener S, Kron A, Frank K, Garbert K, Persigehl T, Püsken M, Haneder S, Schaaf B, Rodermann E, Engel-Riedel W, Felip E, Smit EF, Merkelbach-Bruse S, Reinhardt HC, Kast SM, Wolf J, Rauh D, Büttner R, Sos ML (2018). Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors. Nat Commun.2018 Nov 7;9(1):4655. doi: 10.1038/s41467-018-07078-0
  • Yang D, Denny SK, Greenside PG, Chaikovsky AC, Brady JJ, Ouadah Y, Granja JM, Jahchan NS, Lim JS, Kwok S, Kong CS, Berghoff AS, Schmitt A, Reinhardt HC, Park K-S, Preusser M, Kundaje A, Greenleaf W, Sage J, Winslow MM (2018). Inter-tumoral heterogeneity in SCLC is influenced by the cell-type of origin. Cancer Discov.2018 Oct;8(10):1316-1331. doi: 10.1158/2159-8290.CD-17-0987. Epub 2018 Sep 18
  • Meder L, Schuldt P, Thelen M, Schmitt A, Dietlein F, Klein S, Borchmann S, Wennhold K, Vlasic I, Oberbeck S, Riedel R, Florin A, Golfmann K, Schlößer HA, Odenthal M, Büttner R, Wolf J, Hallek M, Herling M, von Bergwelt-Baildon M, Reinhardt HC, Ullrich RT (2018). Combined VEGF and PD-L1 blockade displays synergistic treatment effects in an autochthonous mouse model of small cell lung cancer. Cancer Res. 2018 May 18. pii: canres.2176.2017. doi: 10.1158/0008-5472.CAN-17-2176. [Epub ahead of print]
  • Knittel G, Rehkämper T, Nieper P, Schmitt A, Flüumann R, Reinhardt HC (2018). DNA damage pathways and B-cell lymphomagenesis. Curr Opin Hematol. 2018 Apr 26. doi: 10.1097/MOH.0000000000000433. [Epub ahead of print]
  • Herling CD, Abedpour N, Weiss J, Schmitt A, Jachimowicz RD, Merkel O, Cartolano M, Oberbeck S, Mayer P, Berg V, Thomalla D, Kutsch N, Stiefelhagen M, Cramer P, Wendtner C-M, Persigehl T, Saleh A, Altmüller J, Nürnberg P, Pallasch C, Achter V, Lang U, Eichhorst E, Castiglione R, Schäfer SC, Büttner R, Kreuzer KA, Reinhardt HC, Hallek M, Frenzel LP, Peifer M (2018). Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia. Nat Commun. 2018 Feb 20;9(1):727. doi: 10.1038/s41467-018-03170-7
  • Welcker D, Jain M, Khurshid S, Jokic M, Höhne M, Schmitt A, Frommolt P, Niessen C, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Hopker K(2018). AATF suppresses apoptosis, promotes proliferation and is critical for KRAS-driven lung cancer. Oncogene.2018 Jan 11. doi: 10.1038/s41388-017-0054-6
  • Schrader A, Crispatzu G, Oberbeck S, Mayer P, Pützer S, von Jan J, Vasyutina E, Warner K, Weit N, Pflug N, Braun T, Andersson E, Yadav B, Riabinska A, Maurer B, Ventura Ferreira M, Beier F, Altmueller J, Lanasa M, Herling CD, Haferlach T, Stilgenbauer S, Hopfinger G, Peifer M, Brümmendorf T, Nuernberg P, Elenitoba-Johnson K, Zha S, Hallek M, Moriggl R, Reinhardt HC, Stern M-H, Mustjoki S, Newrzela S, Frommolt P, Herling M (2018). Integrated genetic profiles of T-PLL implicate a TCL1/ATM-centered model of aberrant, but actionable damage responses. Nat Commun. 2018 Feb 15;9(1):697. doi: 10.1038/s41467-017-02688-6

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Nirmal Robinson

  • Robinson N (2018) Salmonella Typhimurium infection: Type I Interferons
    integrate cellular networks to disintegrate macrophages. Cell Stress, Vol.
    2, No. 2, pp. 37 - 39; DOI: 10.15698/cst2018.02.125

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Elena Rugarli

  • Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola A, Wai T, Barth E, Rugarli EI, Bergami M, Langer T (2018). Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. e9288. doi: 10.1525/emmm.201809288
  • Schatton D, Rugarli EI (2018). Post-transcriptional regulation of mitochondrial function. Curr Opin Physiol. 3, 6-15

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Bernhard Schermer

  • Grundmann F, Müller RU, Reppenhorst A, Hülswitt L, Späth MR, Kubacki T, Scherner M, Faust M, Becker I, Wahlers T, Schermer B, Benzing T, Burst V (2018). Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial. J Am Heart Assoc. 2018 Mar 13;7(6). pii: e008181.
  • Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT (2018). Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 1 4 to control channel activity through increased membrane expression. FASEB J. 2018 Jan;32(1):208-219.
  • Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM (2018). Single nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int. 2018 Mar 9. pii: S0085-2538(18)30056-5.
  • Tröder SE, Ebert LK, Butt L, Assenmacher S, Schermer B, Zevnik B (2018). An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes. PLoS ONE 13 (5): e0196891
  • Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K (2018). AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer .Oncogene. 2018 Mar;37(11):1503-1518.

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Björn Schumacher

  • Habermehl TL, Parkinson KC, Hubbard GB, Ikeno Y, Engelmeyer JI, Schumacher B, Mason JB (2018). Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice. Geroscience. 2018 Dec 13. doi: 10.1007/s11357-018-0049-4. [Epub ahead of print]
  • Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N (2018). Mitochondrial stress prevents C. elegans germline apoptosis via BRCA1/BARD1 tumor suppressor genes independently from its pro-longevity effect. EMBO Rep. 2018,e45856. doi: 10.15252/embr.201845856. Epub 2018 Oct 26.
  • Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F, Vogel W, Klümper N, Nolte H, Wittersheim M, Tharun L, Castiglione R, Krüger M, Schauss A, Perner S, Pasparakis M, Büttner R, Persigehl T, Hucho T, Herter-Sprie GS, Schumacher B, Reinhardt HC (2018). The Cdkn1aSUPER mouse as a novel tool to study p53-mediated tumor suppression. Cell Rep. 2018Oct 23;25(4), 1027-1039. doi: 10.1016/j.celrep.2018.09.079. (*co-corresponding authors)
  • Bianco J, Schumacher B (2018). MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO. Nucleic Acids Resin press
  • Notara M, Behboudifard S, Kluth MA, Maßlo C, Ganss, Frank MH, Schumacher B, Cursiefen C (2018). UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation. Sci Rep. 2018 Aug 22,8(1):12564. doi:10.1038/s41598-018-30021-8.
  • Williams AB, Schumacher B (2018). Nematoda: The Caenorhabditis elegans Model for Innate Immunity Interactions Between Worms and Pathogens, and Their Responses to Immunogenic Damage. Advances in Comparative Immunology. doi.org/10.1007/978-3-319-76768-0_5        
  • Rieckher M, Markaki M, Princz A, Schumacher B, Tavernarakis N (2018). Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans. Cell Rep. 2018 Oct 2;25(1):199-211.e6. doi: 10.1016/j.celrep.2018.09.009      

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Günter Schwarz

  • Grünewald N, Jan A, Salvatico C, Kress V, Renner M, Triller A, Specht CG, Schwarz G (2018). Sequences Flanking the Gephyrin-Binding Site of GlyRβ Tune Receptor Stabilization at Synapses. eNeuro. 2018 Feb 19;5(1). pii: ENEURO.0042-17.2018.

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Eline Slagboom

  • Bas-Hoogendam JM, Harrewijn A, Tissier RLM, van der Molen MJW, van Steenbergen H, van Vliet IM, Reichart CG, Houwing-Duistermaat JJ, SlagboomPE, van der Wee NJA, Westenberg PM. The Leiden Family Lab study on Social Anxiety Disorder: A multiplex, multigenerational family study on neurocognitive endophenotypes. Int J Methods Psychiatr Res. 2018 Jun;27(2):e1616. doi: 10.1002/mpr.1616.
  • Berg NVD, Rodriguez-Girondo M, de Craen AJM, Houwing-Duistermaat JJ, Beekman M, SlagboomPE. Longevity around the turn of the 20th century: life-long sustained survival advantage for parents of today's nonagenarians. J Gerontol A Biol Sci Med Sci. 2018 Mar 27. doi: 10.1093/gerona/gly049.
  • van den Berg N, Rodríguez-Girondo M, van Dijk IK, Mourits RJ, Mandemakers K, Janssens AAPO, Beekman M, Smith KR, SlagboomPE. Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait. Nat Commun. 2019 Jan 7;10(1):35. doi: 10.1038/s41467-018-07925-0.
  • Bos MM, Noordam R, Blauw GJ, SlagboomPE, Rensen PCN, van Heemst D. The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors? J Gerontol A Biol Sci Med Sci. 2018 Oct 13. doi: 10.1093/gerona/gly226.]
  • Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, SlagboomPE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006851. doi: 10.1212/WNL.0000000000006851.
  • Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Böhmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Hartmann AM, Hatzimanolis A, Heiss G, Holliday EG, Joshi PK, Kähönen M, Kardia SLR, Karlsson I, Kleineidam L, Knopman DS, Kochan NA, Konte B, Kwok JB, Le Hellard S, Lee T, Lehtimäki T, Li SC, Liu T, Koini M, London E, Longstreth WT Jr, Lopez OL, Loukola A, Luck T, Lundervold AJ, Lundquist A, Lyytikäinen LP, Martin NG, Montgomery GW, Murray AD, Need AC, Noordam R, Nyberg L, Ollier W, Papenberg G, Pattie A, Polasek O, Poldrack RA, Psaty BM, Reppermund S, Riedel-Heller SG, Rose RJ, Rotter JI, Roussos P, Rovio SP, Saba Y, Sabb FW, Sachdev PS, Satizabal CL, Schmid M, Scott RJ, Scult MA, Simino J, SlagboomPE, Smyrnis N, Soumaré A, Stefanis NC, Stott DJ, Straub RE, Sundet K, Taylor AM, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden A, Vitart V, Voineskos AN, Kaprio J, Wagner M, Wagner H, Weinhold L, Wen KH, Widen E, Yang Q, Zhao W, Adams HHH, Arking DE, Bilder RM, Bitsios P, Boerwinkle E, Chiba-Falek O, Corvin A, De Jager PL, Debette S, Donohoe G, Elliott P, Fitzpatrick AL, Gill M, Glahn DC, Hägg S, Hansell NK, Hariri AR, Ikram MK, Jukema JW, Vuoksimaa E, Keller MC, Kremen WS, Launer L, Lindenberger U, Palotie A, Pedersen NL, Pendleton N, Porteous DJ, Räikkönen K, Raitakari OT, Ramirez A, Reinvang I, Rudan I, Dan Rujescu, Schmidt R, Schmidt H, Schofield PW, Schofield PR, Starr JM, Steen VM, Trollor JN, Turner ST, Van Duijn CM, Villringer A, Weinberger DR, Weir DR, Wilson JF, Malhotra A, McIntosh AM, Gale CR, Seshadri S, Mosley TH Jr, Bressler J, Lencz T, Deary IJ. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2018 May 29;9(1):2098. doi: 10.1038/s41467-018-04362-x.
  • DNA methylation signatures of educational attainment. van Dongen J, Bonder MJ, Dekkers KF, Nivard MG, van Iterson M, Willemsen G, Beekman M, van der Spek A, van Meurs JBJ, Franke L, Heijmans BT, van Duijn CM, Slagboom PE, Boomsma DI; BIOS consortium. DNA methylation signatures of educational attainment. NPJ Sci Learn. 2018 Mar 23;3:7. doi: 10.1038/s41539-018-0020-2.
  • Gardiner SL, de Mutsert R, Trompet S, Boogaard MW, van Dijk KW, Jukema PJW, SlagboomPE, Roos RAC, Pijl H, Rosendaal FR, Aziz NA. Repeat length variations in polyglutamine disease-associated genes affect body mass index. Int J Obes (Lond). 2018 Aug 17. doi: 10.1038/s41366-018-0161-7.
  • de Haan HG, van Hylckama Vlieg A, Lotta LA, Gorski MM, Bucciarelli P, Martinelli I; INVENT consortium, Baglin TP, Peyvandi F, Rosendaal FR. Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes. J Thromb Haemost. 2018 Aug 31. doi: 10.1111/jth.14279.
  • Hamer MA, Pardo LM, Jacobs LC, Deelen J, Uitterlinden AG, SlagboomPE, van Heemst D, Uh HW, Beekman M, Kayser M, Liu F, Gunn DA, Nijsten T. Facial Wrinkles in Europeans: a Genome-Wide Association Study. J Invest Dermatol. 2018 Mar 16. pii: S0022-202X(18)31722-6. doi: 10.1016/j.jid.2017.12.037.
  • 't Hart LM, Vogelzangs N, Mook-Kanamori DO, Brahimaj A, Nano J, van der Heijden AAWA, Willems van Dijk K, Slieker RC, Steyerberg E, Ikram MA, Beekman M, Boomsma DI, van Duijn CM, SlagboomPE, Stehouwer CDA, Schalkwijk CG, Arts ICW, Dekker JM, Dehghan A, Muka T, van der Kallen CJH, Nijpels G, van Greevenbroek M. Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes. J Clin Endocrinol Metab. 2018 Aug 2. doi: 10.1210/jc.2018-01165.
  • den Hollander W, Pulyakhina I, Boer C, Bomer N, van der Breggen R, Arindrarto W, Couthino de Almeida R, Lakenberg N, Sentner T, Laros JFJ, Hoen PAC', SlagboomPE, Nelissen RGHH, van Meurs J, Ramos YFM, Meulenbelt I. Annotating transcriptional effects of genetic variants in disease relevant tissue: Transcriptome-wide allelic imbalance in osteoarthritic cartilage. Arthritis Rheumatol. 2018 Oct 9. doi: 10.1002/art.40748. [Epub ahead of print]
  • Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom PE, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kiel DP. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nat Commun. 2018 Jan 17;9(1):260. doi: 10.1038/s41467-017-02662-2.
  • van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, Melo van Lent D, Tynkkynen J, Fischer K, Hernesniemi J, Metspalu A, Singh-Manoux A, Verhoeven A, Willemsen G, de Leeuw FA, Wagner H, van Dongen J, Hertel J, Budde K, Willems van Dijk K, Weinhold L, Ikram MA, Pietzner M, Perola M, Wagner M, Friedrich N, SlagboomPE, Scheltens P, Yang Q, Gertzen RE, Egert S, Li S, Hankemeier T, van Beijsterveldt CEM, Ramachandran V, Maier W, Peeters CFW, Jörgen Grabe H, Ramirez A, Seshadri S, Haller T, Kivimäki M, Salomaa V, Demirkan A, Boomsma D, van der Flier WM, Amin N, van Duijn CM. Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimers Dement. 2018 Jan 6. pii: S1552-5260(17)33855-4. doi: 10.1016/j.jalz.2017.11.012.
  • Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, Zhu G, Macé A, Sidore C, Trompet S, Mangino M, Sabater-Lleal M, Kemp JP, Abbasi A, Kacprowski T, Verweij N, Smith AV, Huang T, Marzi C, Feitosa MF, Lohman KK, Kleber ME, Milaneschi Y, Mueller C, Huq M, Vlachopoulou E, Lyytikäinen LP, Oldmeadow C, Deelen J, Perola M, Zhao JH, Feenstra B; LifeLines Cohort Study, Amini M; CHARGE Inflammation Working Group, Lahti J, Schraut KE, Fornage M, Suktitipat B, Chen WM, Li X, Nutile T, Malerba G, Luan J, Bak T, Schork N, Del Greco M F, Thiering E, Mahajan A, Marioni RE, Mihailov E, Eriksson J, Ozel AB, Zhang W, Nethander M, Cheng YC, Aslibekyan S, Ang W, Gandin I, Yengo L, Portas L, Kooperberg C, Hofer E, Rajan KB, Schurmann C, den Hollander W, Ahluwalia TS, Zhao J, Draisma HHM, Ford I, Timpson N, Teumer A, Huang H, Wahl S, Liu Y, Huang J, Uh HW, Geller F, Joshi PK, Yanek LR, Trabetti E, Lehne B, Vozzi D, Verbanck M, Biino G, Saba Y, Meulenbelt I, O'Connell JR, Laakso M, Giulianini F, Magnusson PKE, Ballantyne CM, Hottenga JJ, Montgomery GW, Rivadineira F, Rueedi R, Steri M, Herzig KH, Stott DJ, Menni C, Frånberg M, St Pourcain B, Felix SB, Pers TH, Bakker SJL, Kraft P, Peters A, Vaidya D, Delgado G, Smit JH, Großmann V, Sinisalo J, Seppälä I, Williams SR, Holliday EG, Moed M, Langenberg C, Räikkönen K, Ding J, Campbell H, Sale MM, Chen YI, James AL, Ruggiero D, Soranzo N, Hartman CA, Smith EN, Berenson GS, Fuchsberger C, Hernandez D, Tiesler CMT, Giedraitis V, Liewald D, Fischer K, Mellström D, Larsson A, Wang Y, Scott WR, Lorentzon M, Beilby J, Ryan KA, Pennell CE, Vuckovic D, Balkau B, Concas MP, Schmidt R, Mendes de Leon CF, Bottinger EP, Kloppenburg M, Paternoster L, Boehnke M, Musk AW, Willemsen G, Evans DM, Madden PAF, Kähönen M, Kutalik Z, Zoledziewska M, Karhunen V, Kritchevsky SB, Sattar N, Lachance G, Clarke R, Harris TB, Raitakari OT, Attia JR, van Heemst D, Kajantie E, Sorice R, Gambaro G, Scott RA, Hicks AA, Ferrucci L, Standl M, Lindgren CM, Starr JM, Karlsson M, Lind L, Li JZ, Chambers JC, Mori TA, de Geus EJCN, Heath AC, Martin NG, Auvinen J, Buckley BM, de Craen AJM, Waldenberger M, Strauch K, Meitinger T, Scott RJ, McEvoy M, Beekman M, Bombieri C, Ridker PM, Mohlke KL, Pedersen NL, Morrison AC, Boomsma DI, Whitfield JB, Strachan DP, Hofman A, Vollenweider P, Cucca F, Jarvelin MR, Jukema JW, Spector TD, Hamsten A, Zeller T, Uitterlinden AG, Nauck M, Gudnason V, Qi L, Grallert H, Borecki IB, Rotter JI, März W, Wild PS, Lokki ML, Boyle M, Salomaa V, Melbye M, Eriksson JG, Wilson JF, Penninx BWJH, Becker DM, Worrall BB, Gibson G, Krauss RM, Ciullo M, Zaza G, Wareham NJ, Oldehinkel AJ, Palmer LJ, Murray SS, Pramstaller PP, Bandinelli S, Heinrich J, Ingelsson E, Deary IJ, Mägi R, Vandenput L, van der Harst P, Desch KC, Kooner JS, Ohlsson C, Hayward C, Lehtimäki T, Shuldiner AR, Arnett DK, Beilin LJ, Robino A, Froguel P, Pirastu M, Jess T, Koenig W, Loos RJF, Evans DA, Schmidt H, Smith GD, Slagboom PE, Eiriksdottir G, Morris AP, Psaty BM, Tracy RP, Nolte IM, Boerwinkle E, Visvikis-Siest S, Reiner AP, Gross M, Bis JC, Franke L, Franco OH, Benjamin EJ, Chasman DI, Dupuis J, Snieder H, Dehghan A, Alizadeh BZ. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. Am J Hum Genet. 2018 Nov 1;103(5):691-706. doi: 10.1016/j.ajhg.2018.09.009.
  • Luijk R, Dekkers KF, van Iterson M, Arindrarto W, Claringbould A, Hop P; BIOS (Biobank-based Integrative Omics Study) Consortium, Boomsma DI, van Duijn CM, van Greevenbroek MMJ, Veldink JH, Wijmenga C, Franke L, 't Hoen PAC, Jansen R, van Meurs J, Mei H, SlagboomPE, Heijmans BT, van Zwet EW. Genome-wide identification of directed gene networks using large-scale population genomics data. Nat Commun. 2018 Aug 6;9(1):3097. doi: 10.1038/s41467-018-05452-6.
  • Luijk R, Wu H, Ward-Caviness CK, Hannon E, Carnero-Montoro E, Min JL, Mandaviya P, Müller-Nurasyid M, Mei H, van der Maarel SM; BIOS Consortium, Relton C, Mill J, Waldenberger M, Bell JT, Jansen R, Zhernakova A, Franke L, 't Hoen PAC, Boomsma DI, van Duijn CM, van Greevenbroek MMJ, Veldink JH, Wijmenga C, van Meurs J, Daxinger L, SlagboomPE, van Zwet EW, Heijmans BT. Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nat Commun. 2018 Sep 14;9(1):3738. doi: 10.1038/s41467-018-05714-3.

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Peter Tessarz

  • Iyer-Bierhoff A, Krogh N, Tessarz P, Ruppert T, Nielsen H, Grummt I (2018). SIRT7-dependent deacetylation of fibrillarin controls H2A methylation and rRNA synthesis during the cell cycle. Cell Rep. 25 (11):2946-2954.e5.
  • Mylonas C and Tessarz P (2018): NET-prism enables RNA polymerase-dedicated transcriptional interrogation at nucleotide resolution. bioRxiv, 246827
  • Mylonas C and Tessarz P (2018): Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells. Life Science Alliance 1 (3), e201800085

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Marc Tittgemeyer

  • Edwin Thanarajah S, Backes H, DiFeliceantonio A, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Bruening JC, Tittgemeyer M. (2018) Food intake recruits orosensory and post-ingestive dopaminergic circuits to affect eating desire in humans. Cell Metabolism, ePub ahead of print
  • Kuzmanovic B, Rigoux L, Tittgemeyer M. (2018) Influence of vmPFC on dmPFC predicts valence-guided belief formation. The Journal of Neuroscience 38, 7996-8010
  • Gorbach NS, Tittgemeyer M, Buhmann JM. (2018) A Pipeline validation for connectivity-based Cortex parcellation. NeuroImage 181, 219-234.
  • Pelzer EA, Nahhas Y, Tittgemeyer M, Timmermann L, Eggers C. (2018) Altered thalamic glucose metabolism in cerebellar projections in Parkinson’s disease. Basal Ganglia 14, 1-7.
  • Tittgemeyer M, Rigoux L, Knosche TR (2018). Cortical parcellation based on structural connectivity: A case for generative models. NeuroImage173, 592-603.
  • Richter N, Beckers N, Onur OA, Dietlein M, Tittgemeyer M, Kracht L, Neumaier B, Fink GR, Kukolja J. (2018). Effect of cholinergic treatment depends on cholinergic integrity in early Alzheimer's disease. Brain141, 903-915.
  • Nettersheim FS, Loehrer PA, Weber I, Jung F, Dembek TA, Pelzer EA, Dafsari HS, Huber CA, Tittgemeyer M, Timmermann L (2018). Dopamine substitution alters effective connectivity of cortical prefrontal, premotor, and motor regions during complex bimanual finger movements in Parkinson's disease. NeuroImage04 ePub.
  • Michely J, Volz LJ, Hoffstaedter F, Tittgemeyer M, Eickhoff SB, Fink GR, and Grefkes C. (2018). Network connectivity of motor control in the ageing brain. NeuroImage Clin18, 443-455.
  • Hintzen A, Pelzer EA, Tittgemeyer M (2018). Thalamic interactions of cerebellum and basal ganglia. Brain Struct Funct223, 569-587.
  • DiFeliceantonio AG, Coppin G, Rigoux L, Edwin Thanarajah S, Dagher A, Tittgemeyer M, Small DM (2018). Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward. Cell Metab28, 33-44 e33.

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Alexandra Trifunovic

  • Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A (2018). CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep. 2018 Mar 27. pii: e45126. doi: 10.15252/embr.201745126. [Epub ahead of print]. PMID: 29588285

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Mirka Uhlirova

  • Donohoe CD, Csordás G, Correia A, Jindra M, Klein C, Habermann B, Uhlirova M (2018). Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture. PLoS Genet 14: e1007241–32, doi:10.1371/journal.pgen.1007241.
  • Martinez Carrera LA, Gabriel E, Donohoe CD, Hölker I, Mariappan A, Storbeck M, Uhlirova M, Gopalakrishnan J, Wirth B (2018). Novel insights into SMALED2: BICD2 mutations increase microtubule stability and cause defects in axonal and NMJ development. Human Molecular Genetics, 10:1772-1784, DOI:10.1093/hmg/ddy086.

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Dario Valenzano

  • Dodzian J, Kean S, Seidel J, Valenzano DR (2018). A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri). JoVE (134), e57073       
  • Muck J, Kean S, Valenzano DR (2018). The short-lived African turquoise killifish (Nothobranchius furzeri): a new model system for research on ageing. Handbook of Models of Human Aging, 2nd Ed (May 2018). ISBN: 978-0-12-811353-0               
  • Seidel J, Valenzano DR (2018). The role of the gut microbiome during host ageing. F1000Res. 2018, 7(F1000 Faculty Rev):1086. doi: 10.12688/f1000research.15121.1                  
  • Valenzano DR (2018). Host-microbiota interactions during ageing. Old Herborn University Seminar Monograph 32: Ageing and the Microbiome. Old Herborn University Foundation, Herborn, Germany: 33-41                

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David Vilchez

  • Saez I, Koyuncu S, Gutierrez-Garcia R, Dieterich C, Vilchez D (2018). Insights into the ubiquitin-proteasome system of human embryonic stem cells. Sci Rep. 2018 Mar 6;8(1):4092    
  • Noormohammadi A, Calculli G, Gutierrez-Garcia R, Khodokarami A, Koyuncu S, Vilchez D (2018). Mechanisms of protein homeostasis (proteostasis) mantain stem cell identity in mammalian pluripotent stem cells. Cell Mol LifeSci. 2018 Jan;75(2):275-290. doi: 10.1007/s00018-017-2602-1. Epub 2017 Jul 26          
  • Gonçalves I, Brecht J, Thelen M, Rehorst W, Peters M, Lee HJ, Motameny S, Torres-Benito L, Ebrahimi-Fakhari D, Kononenko N, Altmüller J, Vilchez D, Sahin M, Wirth B, Kye MJ (2018). Neuronal activity regulates DROSHA via autophagy in Spinal Muscular Atrophy. Sci Rep. 2018 May 21;8(1):7907. doi: 10.1038/s41598-018-26347-y             
  • Koyuncu S, Saez I, Lee HJ, Gutierrez-Garcia R, Pokrzywa W, Fatima A, Hoppe T, Vilchez D (2018). The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat Commun. 9: 2886            
  • Irmak D, Fatima A, Gutierrez-Garcia R, Rinschen M, Wagle P, Altmüller J, Arrigoni L, Hummel B, Klein C, Frese CK, Sawarkar R, Rada-Iglesias A, Vilchez D (2018). Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations. Hum Mol Genet. 2018 Dec 1;27(23):4117-4134. doi: 10.1093/hmg/ddy304

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Silvia von Karstedt

  • García-Reyes B, Kretz AL, Ruff JP, von Karstedt S, Hillenbrand A, Knippschild U, Henne-Bruns D, Lemke J. The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma. International journal of molecular sciences. 2018 Oct 18;19(10). pii: E3219. doi: 10.3390/ijms19103219.
  • Kretz AL, von Karstedt S, Hillenbrand A, Henne-Bruns D, Knippschild U, Trauzold A, Lemke J. Should we keep walking along the TRAIL for pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-inducing Ligand for Anticancer Therapy. Cancers 2018 Mar 18;10(3). pii: E77. doi: 10.3390/cancers10030077.
  • Von Karstedt, S; NDRG2 programs Tumor-Associated Macrophages for Tumor support. Cell Death and Disease. 2018 Feb 20;9(3):294. doi: 10.1038/s41419-018-0268-8.
  • Krishna K. Kolluri, Constantine Alifrangis, Neelam Kumar, Stacey Price, Magali Michaut, Steven Williams, Syd Barthorpe, Yuki Ishii, Howard Lightfoot, Sara Busacca, Annabel Sharkey, Zhenqiang Yuan, Elizabeth K. Sage, Sabarinath Vallath, John Le Quesne, David A. Tice, Doraid Alrifai, Silvia von Karstedt, Antonella Montinaro, Naomi Guppy, David A. Waller, Apostolos Nakas, Robert Good, Alan Holmes, Henning Walczak, Dean A. Fennell, Mathew J. Garnett, Francesco Iorio, Lodewyk F. A. Wessels, Ultan McDermott, Sam M. Janes; Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. Elife. 2018 Jan 18;7. pii: e30224. doi: 10.7554/eLife.30224.

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Rudolf J. Wiesner

  • Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR (2018). Imbalance of mitochondrial respiratory chain complexes in the epidermis induces severe skin inflammation. J Invest Dermatol 138: 132-140.

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Andreas Wodarz

  • Ripp C, Loth J, Petrova I, Linnemannstöns K, Ulepic M, Fradkin L, Noordermeer J, Wodarz A (2018). Drosophila Ror is a nervous system-specific coreceptor for Wnt ligands. Biol Open 7doi 10.1242/bio.033001.
  • Beati H, Peek I, Hordowska P, Honemann‑Capito M, Glashauser J, Renschler FA, Kakanj P, Ramrath A, Leptin M, Luschnig S, Wiesner S, Wodarz A (2018). The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. J Cell Biol. 217, 1079-1095.
  • Rust K, Tiwari M, Mishra V K, Grawe F, Wodarz A (2018). Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila. EMBO J, 37, e98659.

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Thomas Wunderlich

  • Mittenbuhler MJ, Sprenger HG, Gruber S; Wunderlich CM, Kern L, Bruning JC, Wunderlich FT (2018).Hepatic leptin receptor expression can partially compensate for IL-6Ralpha deficiency in DEN-induced hepatocellular carcinoma. Mol Metab. 2018, 17, 122-133, doi:10.1016/j.molmet.2018.08.010
  • Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Hohne M, Rauh M, Gobel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC (2018). Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Exp Mol Med. 2018, 50, 75, doi:10.1038/s12276-018-0108-z
  • Wunderlich CM, Ackermann PJ, Ostermann AL, Adams-Quack P, Vogt MC, Tran ML, Nikolajev A, Waisman A; Garbers C, Theurich S, Mauer J, Hövelmeyer N, Wunderlich FT (2018). Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nat Commun. 2018, 9, 1646, doi:10.1038/s41467-018-03773-0
  • Hahn M, Burckert JP, Luttenberger CA, Klebow S, Hess M, Al-Maarri M, Vogt M, Reissig S, Hallek M, Wienecke-Baldacchino A, Buch T, Muller CP, Pallasch CP, Wunderlich FT, Waisman A, Hövelmeyer N (2018). Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-kappaB signaling. Leukemia 2018 Jan;32(1):72-82. doi: 10.1038/leu.2017.168. Epub 2017 Jun 1

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Branko Zevnik

  • Tröder SE, Ebert LK, Butt L, Assenmacher S, Schermer B, Zevnik B (2018). An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes. PLoS ONE 13 (5): e0196891

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