CECAD

Publications 2019

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Adam Antebi

  • Annibal A, Tam H, Latza C, Antebi A (2019). Comparison of ESI-MS/MS and APCI-MS methods for the quantification of folic acid analogs in C. elegans. J Mass Spectrom. 2019 Apr;54(4):316-327. doi: 10.1002/jms.4337
  • Dolfi L, Ripa R, Antebi A, Valenzano DR, Cellerino A (2019). Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology. Evodevo. 2019 Nov 8;10:29. doi: 10.1186/s13227-019-0142-5. eCollection 2019  
  • Guerra BA, Brandão BB, Pinto SS, Salgueiro WG, De-Souza EA, Reis FCG, Batista TM, Cavalcante-Silva V, D'Almeida V, Castilho BA, Carneiro EM, Antebi A, Festuccia WT, Mori MA (2019). Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects. Mol Metab. 2019 Nov;29:124-135. doi:10.1016/j.molmet.2019.08.017. Epub 2019 Aug 28
  • Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G (2019). To help aging populations, classify organismal senescence. Science. 2019 Nov 1;366(6465):576-578. doi: 10.1126/science.aay7319    
  • Zhou Y, Wang X, Song M, He Z, Cui G, Peng G, Dieterich C, Antebi A, Jing N, Shen Y (2019). A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing. Nat Commun. 2019 Oct 23;10(1):4827. doi: 10.1038/s41467-019-12821-2     
  • Lesanpezeshki L, Hewitt JE, Laranjeiro R, Antebi A, Driscoll M, Szewczyk NJ, Blawzdziewicz J, Lacerda CMR, Vanapalli SA (2019). Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans. Sci Rep. 2019 Oct 23;9(1):15246. doi: 10.1038/s41598-019-51608-9    
  • Fischer J, Gutièrrez S, Ganesan R, Calabrese C, Ranjan R, Cildir G, Hos NJ, Rybniker J, Wolke M, Fries JWU, Tergaonkar V, Plum G, Antebi A, Robinson N (2019). Leptin signaling impairs macrophage defenses against Salmonella Typhimurium. Proc Natl Acad Sci USA. 2019 Aug 13;116(33):16551-16560. doi: 10.1073/pnas.1904885116. Epub 2019 Jul 26     
  • Antebi A (2019).Developmental Timing: Honey, I Reprogrammed the Kids. Curr Biol. 2019 Jun 3;29(11):R420-R422. doi: 10.1016/j.cub.2019.04.054 
  • De-Souza EA, Camara H, Salgueiro WG, Moro RP, Knittel TL, Tonon G, Pinto S, Pinca APF, Antebi A, Pasquinelli AE, Massirer KB, Mori MA (2019). RNA interference may result in unexpected phenotypes in Caenorhabditis elegans. Nucleic Acids Res. 2019 May 7;47(8):3957-3969. doi: 10.1093/nar/gkz154      
  • Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T (2019). Suppression of autophagic activity by Rubicon is a signature of aging. Nat Commun. 2019 Feb 19;10(1):847. doi: 10.1038/s41467-019-08729-6

Thomas Benzing

  • Braun F, Blomberg L, Brodesser S, Liebau MC, Schermer B, Benzing T, Kurschat CE (2019). Enzyme Replacement Therapy Clears Gb3 Deposits from a Podocyte Cell Culture Model of Fabry Disease but Fails to Restore Altered Cellular Signaling. Cell Physiol Biochem. 2019;52(5):1139-1150. doi: 10.33594/000000077  
  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM (2019). The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3    
  • Ignarski M, Rill C, Kaiser RWJ, Kaldirim M, Neuhaus R, Esmaillie R, Li X, Klein C, Bohl K, Petersen M, Frese CK, Höhne M, Atanassov I, Rinschen MM, Höpker K, Schermer B, Benzing T, Dietrich C, Fabretti F, Müller RU (2019). The RNA-protein interactome of differentiated kidney tubular epithelial cells. J Am Soc Nephrol. 2019 Apr;30(4):564-576. doi: 10.1681/ASN.2018090914. Epub 2019 Mar 13
  • Jain M, Kaiser RWJ, Bohl K, Hoehne M, Göbel H, Bartram MP, Habbig S, Müller RU, Fogo AB, Benzing T, Schermer B, Höpker K, Slaats GG (2019). Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis. Kidney Int. 2019 Apr;95(4):846-858. doi: 10.1016/j.kint.2018.10.034. Epub 2019 Feb 13  
  • Braun F, Suarez V, Dinter J, Haneder S, Quaas A, Benzing T, Nierhoff D, Müller RU (2019). Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura. BMJ Open Gastroenterol. 2019 Feb 8;6(1):e000252. doi: 10.1136/bmjgast-2018-000252. eCollection 2019  
  • Assady S, Benzing T, Kretzler M, Skorecki KL (2019). Glomerular podocytes in kidney health and disease. Lancet. 2019 Mar 2;393(10174):856-858. doi: 10.1016/S0140-6736(18)33000-9   
  • Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S. Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB (2019). Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012
  • Burgmaier K, Kilian S, Bammens B, Benzing T, Billing H, Buscher A, Galiano M, Grundmann F, Klaus G, Mekahli D, Michel-Calemard L, Milosevski-Lomic G, Ranchin B, Sauerstein K, Schaefer S, Shroff R, Sterenborg R, Verbeeck S, Weber LT, Wicher D, Wühl E, Dötsch J, Schaefer F, Liebau MC (2019). Clinical courses and complications of young adults with Autosomal Recessive Polycystic Kidney Disease (ARPKD). Sci Rep. 2019 May 28;9(1):7919. doi: 10.1038/s41598-019-43488-w    
  • Kaiser RWJ, Ignarski M, Nostrand ELV, Frese CK, Jain M, Cukoski S, Heinen H, Schaechter M, Seufert L, Bunte K, Frommolt P, Keller P, Helm M, Bohl K, Höhne M, Schermer B, Benzing T, Höpker K, Dietrich C, Yeo GW, Müller RU, Fabretti F (2019). A protein-RNA interaction atlas of the ribosome biogenesis factor AATF. Sci Rep. 2019 Jul 30;9(1):11071. doi: 10.1038/s41598-019-47552-3     
  • Meyer AM, Siri G, Becker I, Betz T, Bodecker AW, Robertz JW, Krause O, Benzing T, Pilotto A, Polidori MC (2019). The Multidimensional Prognostic Index in general practice: One-year follow-up study. Int J Clin Pract. 2019 Aug 13:e13403. doi: 10.1111/ijcp.13403. [Epub ahead of print]     
  • Meyer AM, Becker I, Siri G, Brinkkötter PT, Benzing T, Pilotto A, Polidori MC (2019). New associations of the Multidimensional Prognostic Index. Z Gerontol Geriatr. 2019 Aug;52(5):460-467. doi: 10.1007/s00391-018-01471-6. Epub 2018 Nov 7    
  • Meyer AM, Becker I, Siri G, Brinkkötter PT, Benzing T, Pilotto A, Polidori MC (2019). New associations of the Multidimensional Prognostic Index. Z Gerontol Geriatr. 2019 Aug;52(5):460-467. doi: 10.1007/s00391-018-01471-6. Epub 2018 Nov 7   
  • Phipps EA, Thadhani R, Benzing T, Karumanchi SA (2019). Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019 May;15(5):275-289. doi: 10.1038/s41581-019-0119-6     
  • Schermer B, Benzing T (2019). [Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine?]. Dtsch Med Wochenschr. 2019 Feb;144(4):276-281. doi: 10.1055/a-0759-7180. Epub 2019 Feb 13 
  • Völker LA, Burkert K, Scholten N, Grundmann F, Kurschat C, Benzing T, Hampl J, Becker JU, Müller RU (2019). A case report of recurrent membranoproliferative glomerulonephritis after kidney  transplantation due to ventriculoatrial shunt infection. BMC Nephrol. 2019 Aug 5;20(1):296. doi: 10.1186/s12882-019-1472-1  
  • Völker LA, Ehren R, Grundmann F, Benzing T, Weber LT, Brinkkötter PT (2019). A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany. Nephrol Dial Transplant. 2019 Dec 1;34(12):1983-1986. doi: 10.1093/ndt/gfz046     
  • Wöstmann F, Müller RU, Göbel H, Benzing T, Becker JU, Bartram MP (2019). Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome. BMC Nephrol. 2019 Aug 22;20(1):326. doi: 10.1186/s12882-019-1478-8

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Matteo Bergami

  • Sprenger HS, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T (2019). Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2019 Jan;11(1). pii: e9288. doi: 10.15252/emmm.201809288  
  • Riedemann S, Sutor B, Bergami M, Riedemann T (2019). Gad1-promotor-driven GFP expression in non-GABAergic neurons of the nucleus endopiriformis in a transgenic mouse line. J Comp Neurol. 2019 Oct 1;527(14):2215-2232. doi: 10.1002/cne.24673. Epub 2019 Mar 20  
  • Ren SQ, Li Z, Lin S, Bergami M, Shi SH (2019). Precise Long-Range Microcircuit-to-Microcircuit Communication Connects the Frontal and Sensory Cortices in the Mammalian Brain. Neuron. 2019 Oct 23;104(2):385-401.e3. doi: 10.1016/j.neuron.2019.06.028. Epub 2019 Jul 29  
  • Rangaraju V, Lewis TL Jr, Hirabayashi Y, Bergami M, Motori E, Cartoni R, Kwon SK, Courchet J (2019). Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease. J Neurosci. 2019 Oct 16;39(42):8200-8208. doi: 10.1523/JNEUROSCI.1157-19.2019   

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Andreas Beyer

  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM (2019). The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3 
  • Soste M, Charmpi K, Lampert F, Gerez JA, van Oostrum M, Malinovska L, 
    Boersema PJ, Prymaczok NC, Riek R, Peter M, Vanni S, Beyer A, Picotti 
    P (2019). Proteomics-based monitoring of pathway activity reveals that 
    blocking diacylglycerol biosynthesis rescues from alpha-synuclein 
    toxicity. Cell Syst. 2019 Sep 25;9(3):309-320.e8. doi: 10.1016/j.cels.2019.07.010. Epub 2019 Sep 11  
  • Lapin D, Kovacova V, Sun X, Dongus JA, Bhandari D, von Born P, Bautor J, Guarneri N, Rzemieniewski J, Stuttmann J, Beyer A, Parker JE (2019). A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors. Plant Cell. 2019 Oct;31(10):2430-2455. doi: 10.1105/tpc.19.00118. Epub 2019 Jul 16  
  • Shao W, Guo T, Toussaint NC, Xue P, Wagner U, Li L, Charmpi K, Zhu Y, Wu J, Buljan M, Sun R, Rutishauser D, Hermanns T, Fankhauser CD, Poyet C, Ljubicic J, Rupp N, Rüschoff JH, Zhong Q, Beyer A, Ji J, Collins BC, Liu Y, Rätsch G, Wild PJ, Aebersold R (2019). Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins. Nat Commun. 2019 Jun 7;10(1):2524. doi: 10.1038/s41467-019-10513-5  
  • Debès C, Leote AC, Beyer A (2019). Computational approaches for the systematic analysis of ageing-associated molecular alterations (Review). Drug Discov Tod. Disease Mod. 27:51-59; https://doi.org/10.1016/j.ddmod.2019.03.003  
  • Hahn O, Drews LF, Nguyen A, Tatsuta T, Gkioni L, Hendrich O, Zhang Q, Langer T, Pletcher S, Wakelam MJO, Beyer A, Grönke S, Partridge L (2019). A nutritional memory effect counteracts the benefits of dietary restriction in old mice. Nat Metab. 1059–1073

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Susanne Brodesser

  • Yu H, Dilbaz S, Coßmann J, Hoang AC, Diedrich V, Herwig A, Harauma A, Hoshi Y, Moriguchi T, Landgraf K, Körner A, Lucas C, Brodesser S, Balogh L, Thuróczy J, Karemore G, Kuefner MS, Park EA, Rapp C, Travers JB, Röszer T (2019). Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. J Clin Invest. 2019 May 13;130:2485-2499. doi: 10.1172/JCI125646. eCollection 2019 May 13
  • Braun F, Blomberg L, Brodesser S, Liebau MC, Schermer B, Benzing T, Kurschat CE (2019). Enzyme Replacement Therapy Clears Gb3 Deposits from a Podocyte Cell Culture Model of Fabry Disease but Fails to Restore Altered Cellular Signaling. Cell Physiol Biochem. 2019;52(5):1139-1150. doi: 10.33594/000000077
  • Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI (2019). Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. 2019 Aug;67(8):1526-1541. doi: 10.1002/glia.23626. Epub 2019 Apr 16
  • Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L (2019). Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep. 2019 Apr;20(4). pii: e47407. doi: 10.15252/embr.201847407. Epub 2019 Mar 18
  • Farowski F, Solbach P, Tsakmaklis A, Brodesser S, Cruz Aguilar MR, Cornely OA, Dettmer K, Higgins PG, Suerbaum S, Jazmati N, Oefner PJ, Vehreschild MJGT (2019). Potential biomarkers to predict outcome of faecal microbiota transfer for recurrent Clostridioides difficile infection. Dig Liver Dis. 2019 Jul;51(7):944-951. doi: 10.1016/j.dld.2019.01.012. Epub 2019 Jan 26
  • Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC (2019). CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031
  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM (2019). The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3
  • Rashid T, Nemazanyy I, Paolini C, Tatsuta T, Crespin P, de Villeneuve D, Brodesser S, Benit P, Rustin P, Baraibar MA, Agbulut O, Olivier A, Protasi F, Langer T, Chrast R, de Lonlay P, de Foucauld H, Blaauw B, Pende M (2019). Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. EMBO J. 2019 Jan 3;38(1). pii: e99576. doi: 10.15252/embj.201899576. Epub 2018 Nov 12

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Jens Brüning  

  • Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC (2019). CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031 
  • Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Bruning JC, Tittgemeyer M (2019). Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metab. 2019 Mar 5;29(3):695-706.e4. doi: 10.1016/j.cmet.2018.12.006. Epub 2018 Dec 27  
  • Raichur S, Brunner B, Bielohuby M, Hansen G, Pfenninger A, Wang B, Bruning JC, Larsen PJ, Tennagels N (2019). The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach. Mol Metab. 2019 Mar;21:36-50. doi: 10.1016/j.molmet.2018.12.008. Epub 2019 Jan 2  
  • Lippert RN, Cremer AL, Edwin Thanarajah S, Korn C, Jahans-Price T, Burgeno LM, Tittgemeyer M, Brüning JC, Walton ME, Backes H (2019). Time-dependent assessment of stimulus-evoked regional dopamine release. Nat Commun. 2019 Jan 18;10(1):336. doi: 10.1038/s41467-018-08143-4
  • Wang L, De Solis AJ, Goffer Y, Birkenbach KE, Engle SE, Tanis R, Levenson JM, Li X, Rausch R, Purohit M, Lee JY, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G (2019). Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight. 2019 Feb 7;4(3). pii: 123337. doi: 10.1172/jci.insight.123337. [Epub ahead of print]  
  • Edwin Thanarajah S, Iglesias S, Kuzmanovic B, Rigoux L, Stephan KE, Brüning JC, Tittgemeyer M (2019). Modulation of midbrain neurocircuitry by intranasal insulin. Neuroimage. 2019 Jul 1;194:120-127. doi: 10.1016/j.neuroimage.2019.03.050. Epub 2019 Mar 23  
  • Ip CK, Zhang L, Farzi A, Qi Y, Clarke I, Reed F, Shi YC, Enriquez R, Dayas C, Graham B, Begg D, Brüning JC, Lee NJ, Hernandez-Sanchez D, Gopalasingam G, Koller J, Tasan R, Sperk G, Herzog H (2019). Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. Cell Metab. 2019 Jul 2;30(1):111-128.e6. doi: 10.1016/j.cmet.2019.04.001. Epub 2019 Apr 25  
  • Edwin Thanarajah S, Hoffstall V, Rigoux L, Hanssen R, Brüning JC, Tittgemeyer M (2019). The role of insulin sensitivity and intranasally applied insulin on olfactory perception. Sci Rep. 2019 May 10;9(1):7222. doi: 10.1038/s41598-019-43693-7  
  • Hammerschmidt P, Ostkotte D, Nolte H, Gerl MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC (2019). CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell. 2019 May 30;177(6):1536-1552.e23. doi: 10.1016/j.cell.2019.05.008  
  • Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning JC (2019). The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. Cell Rep. 2019 Jun 11;27(11):3182-3198.e9. doi: 10.1016/j.celrep.2019.05.037 
  • Cheng Y, Luo H, Izzo F, Pickering BF, Nguyen D, Myers R, Schurer A, Gourkanti S, Brüning JC, Vu LP, Jaffrey SR, Landau DA, Kharas MG (2019). m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell Rep. 2019 Aug 13;28(7):1703-1716.e6. doi: 10.1016/j.celrep.2019.07.032  
  • MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Krüger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Brüning JC, Zamboni N, Langer T (2019). Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature. 2019 Nov;575(7782):361-365. doi: 10.1038/s41586-019-1738-6. Epub 2019 Nov 6    

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Oliver Cornely

  • Seidel D, Meissner A, Lackner M, Piepenbrock E, Salmanton-Garcia J, Stecher M, Mellinghoff S, Hamprecht A, Duran Graeff L, Kohler P, Cheng MP, Denis J, Chedotal I, Chander J, Pakstis DL, Los-Arcos I, Slavin M, Montagna MT, Caggiano G, Mares M, Trauth J, Aurbach U, Vehreschild M, Vehreschild JJ, Duarte RF, Herbrecht R, Wisplinghoff H, Cornely OA (2019). Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope((R)). Crit Rev Microbiol. 2019 Feb;45(1):1-21. doi: 10.1080/1040841X.2018.1514366. Epub 2019 Jan 10
  • Mellinghoff SC, Vehreschild JJ, Liss BJ, Cornely OA (2019). Metadata Correction: Epidemiology of Surgical Site Infections With Staphylococcus aureus in Europe: Protocol for a Retrospective, Multicenter Study. JMIR Res Protoc. 2019 Jan 7;8(1):e10712. doi: 10.2196/10712
  • Koehler P, Mellinghoff SC, Lagrou K, Alanio A, Arenz D, Hoenigl M, Koehler FC, Lass-Florl C, Meis JF, Richardson M, Cornely OA (2019). Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology. J Antimicrob Chemother. 2019 Jun 1;74(6):1704-1712. doi: 10.1093/jac/dkz051
  • Koehler P, Jung N, Cornely OA, Rybniker J, Fatkenheuer G (2019). Combination Antimicrobial Therapy for Enterococcus faecalis Infective Endocarditis. Clin Infect Dis. 2019 Feb 1. doi: 10.1093/cid/ciz054. [Epub ahead of print
  • Gerding DN, Cornely OA, Grill S, Kracker H, Marrast AC, Nord CE, Talbot GH, Buitrago M, Gheorghe Diaconescu I, Murta de Oliveira C, Preotescu L, Pullman J, Louie TJ, Wilcox MH (2019). Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials. Lancet Infect Dis. 2019 Mar;19(3):265-274. doi: 10.1016/S1473-3099(18)30614-5. Epub 2019 Jan 29
  • Farowski F, Solbach P, Tsakmaklis A, Brodesser S, Cruz Aguilar MR, Cornely OA, Dettmer K, Higgins PG, Suerbaum S, Jazmati N, Oefner PJ, Vehreschild MJGT (2019). Potential biomarkers to predict outcome of faecal microbiota transfer for recurrent Clostridioides difficile infection. Dig Liver Dis. 2019 Jul;51(7):944-951. doi: 10.1016/j.dld.2019.01.012. Epub 2019 Jan 26
  • Oladele RO, Osaigbovo, II, Ayanlowo OO, Otu AA, Hoenigl M, Cornely OA, Chakrabarti A, Denning DW (2019). The role of medical mycology societies in combating invasive fungal infections in low- and middle-income countries: A Nigerian model. Mycoses 2019 Jan;62(1):16-21. doi: 10.1111/myc.12845. Epub 2018 Oct 8       
  • Mellinghoff SC, von Bergwelt-Baildon M, Schosser HA, Cornely OA (2019). A novel approach to candidemia? The potential role of checkpoint inhibition. Med Mycol. 2019 Feb 1;57(2):151-154. doi: 10.1093/mmy/myy089  
  • Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Bruning JC, Tittgemeyer M (2019). Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metab. 2019 Mar 5;29(3):695-706.e4. doi: 10.1016/j.cmet.2018.12.006. Epub 2018 Dec 27 
  • Wilcox MH, Cornely OA, Guery B, Longshaw C, Georgopali A, Karas A, Kazeem G, Palacios-Fabrega JA, Vehreschild M (2019). Microbiological Characterization and Clinical Outcomes After Extended-Pulsed Fidaxomicin Treatment for Clostridioides difficile Infection in the EXTEND Study. Open Forum Infect Dis. 2019 Nov 6;6(11):ofz436. doi: 10.1093/ofid/ofz436. eCollection 2019 Nov  
  • Lilienfeld-Toal M von, Wagener J, Einsele H, Cornely OA, Kurzai O (2019). Invasive Fungal Infection. Dtsch Arztebl Int. 2019; 116(16): 271-8    
  • Steinbach A, Cornely OA, Wisplinghoff H, Schauss AC, Vehreschild JJ, Rybniker J, Hamprecht A, Richter A, Bacher P, Scheffold A, Koehler P (2019). Mould-reactive T cells for the diagnosis of invasive mould infection-A prospective study. Mycoses. 2019 Jul;62(7):562-569. doi: 10.1111/myc.12919. Epub 2019 May 23 
  • Schwarz P, Cornely OA, Dannaoui E (2019). Antifungal combinations in Mucorales: a microbiological perspective. Mycoses. 2019 Sep;62(9):746-760. doi: 10.1111/myc.12909. Epub 2019 Jul 19    
  • Schwartz S, Cornely OA, Hamed K, Marty FM, Maertens J, Rahav G, Herbrecht R, Heinz WJ (2019). Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system. Med Mycol. 2019 Oct 15. pii: myz103. doi: 10.1093/mmy/myz103. [Epub ahead of print]      
  • Salmanton-Garcia J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N, Racil Z, Falces-Romero I, Ingram P, Benitez-Penuela MA, Rodriguez JY, Desoubeaux G, Barac A, Garcia-Vidal C, Hoenigl M, Mehta SR, Cheng MP, Klyasova G, Heinz WJ, Iqbal N, Krause R, Ostermann H, Penack O, Schalk E, Sheppard DC, Willinger B, Wisplinghoff H, Vehreschild JJ, Cornely OA, Vehreschild M (2019). Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn). J Antimicrob Chemother. 2019 Nov 1;74(11):3315-3327. doi: 10.1093/jac/dkz344     
  • Rammaert B, Puyade M, Cornely OA, Seidel D, Grossi P, Husain S, Picard C, Lass-Florl C, Manuel O, Le Pavec J, Lortholary O (2019). Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology. Transpl Infect Dis.2019: 2019 Oct;21(5):e13141. doi: 10.1111/tid.13141. Epub 2019 Jul 22   
  • Mellinghoff SC, Otto C, Cornely OA (2019). Surgical site infections: current management and role of new antibiotics. Curr Opin Infect Dis. 2019 Oct;32(5):517-522. doi: 10.1097/QCO.0000000000000589    
  • Maschmeyer G, Ostermann H, Von Lilienfeld-Toal M, Rieger C, Vehreschild M, Cornely OA, Buchheidt D (2019). Pitfalls in der antimikrobiellen Therapie – Hinweise der Arbeitsgemeinschaft Infektionen in der Hämatologie und Onkologie (AGIHO). DGHO Mitgliederrundschreiben 2019; (1/2019)   
  • Koehler P, Stecher M, Cornely OA, Koehler D, Vehreschild M, Bohlius J, Wisplinghoff H, Vehreschild JJ (2019). Morbidity and mortality of candidaemia in Europe: an epidemiologic meta-analysis. Clin Microbiol Infect. 2019 Oct;25(10):1200-1212. doi: 10.1016/j.cmi.2019.04.024. Epub 2019 Apr 27    
  • Koehler P, Salmanton-Garcia J, Grafe SK, Koehler FC, Mellinghoff SC, Seidel D, Steinbach A, Cornely OA (2019). Baseline predictors influencing the prognosis of invasive aspergillosis in adults. Mycoses. 2019 Aug;62(8):651-658. doi: 10.1111/myc.12926. Epub 2019 May 23   
  • Koehler P, Reimer R, Wahlba R, Schomig-Markiefka B, Cornely OA (2019). Transdiaphragmatic Mucormycosis. Clin Infect Dis. 2019 Jun 19. pii: ciz533. doi: 10.1093/cid/ciz533. [Epub ahead of print]    
  • Koehler P, Bassetti M, Kochanek M, Shimabukuro-Vornhagen A, Cornely OA (2019). Intensive Care management of influenza-associated pulmonary aspergillosis. Clin Microbiol Infect. 2019 Dec;25(12):1501-1509. doi: 10.1016/j.cmi.2019.04.031. Epub 2019 May 16    
  • Koehler P, Arendrup MC, Arikan-Akdagli S, Bassetti M, Bretagne S, Klingspor L, Lagrou K, Meis JF, Rautemaa-Richardson R, Schelenz S, Hamprecht A, Koehler FC, Kurzai O, Salmanton-Garcia J, Vehreschild JJ, Alanio A, Alastruey-Izquierdo A, Arsic Arsenijevic V, Gangneux JP, Gow NAR, Hadina S, Hamal P, Johnson E, Klimko N, Lass-Florl C, Mares M, Ozenci V, Papp T, Roilides E, Sabino R, Segal E, Talento AF, Tortorano AM, Verweij PE, Hoenigl M, Cornely OA (2019). ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies. Mycoses. 2019 Oct;62(10):920-927. doi: 10.1111/myc.12963. Epub 2019 Aug 1   
  • Jakob CEM, Stecher M, Classen AY, Hamprecht A, Cornely OA, Vehreschild JJ (2019). Association Between Prescribed Opioids and Infections in Patients Neutropenia and Cancer. JAMA Intern Med. 2019 Nov 4. doi: 10.1001/jamainternmed.2019.4714. [Epub ahead of print]    
  • Hamprecht A, Barber AE, Mellinghoff SC, Thelen P, Walther G, Yu Y, Neurgaonkar P, Dandekar T, Cornely OA, Martin R, Kurzai O (2019). Candida auris in Germany and Previous Exposure to Foreign Healthcare. Emerg Infect Dis. 2019 Sep;25(9):1763-1765. doi: 10.3201/eid2509.190262. Epub 2019 Sep 17    
  • Gangneux JP, Lortholary O, Cornely OA, Pagano L (2019). 9th Trends in Medical Mycology Held on 11-14 October 2019, Nice, France, Organized under the Auspices of EORTC-IDG and ECMM. J Fungi (Basel) 2019 Oct 8;5(4). pii: E95. doi: 10.3390/jof5040095    
  • Cornely OA, Vehreschild M, Adomakoh N, Georgopali A, Karas A, Kazeem G, Guery B (2019). Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection: EXTEND study subgroup analyses. Eur J Clin Microbiol Infect Dis. 2019 Jun;38(6):1187-1194. doi: 10.1007/s10096-019-03525-y. Epub 2019 Mar 25    
  • Cornely OA, Hoenigl M, Lass-Florl C, Chen SC, Kontoyiannis DP, Morrissey CO, Thompson GR 3rd (2019). Defining breakthrough invasive fungal infection-Position paper of the mycoses study group education and research consortium and the European Confederation of Medical Mycology. Mycoses. 2019 Sep;62(9):716-729. doi: 10.1111/myc.12960. Epub 2019 Jul 19   
  • Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, Hoenigl M, Jensen HE, Lagrou K, Lewis RE, Mellinghoff SC, Mer M, Pana ZD, Seidel D, Sheppard DC, Wahba R, Akova M, Alanio A, Al-Hatmi AMS, Arikan-Akdagli S, Badali H, Ben-Ami R, Bonifaz A, Bretagne S, Castagnola E, Chayakulkeeree M, Colombo AL, Corzo-Leon DE, Drgona L, Groll AH, Guinea J, Heussel CP, Ibrahim AS, Kanj SS, Klimko N, Lackner M, Lamoth F, Lanternier F, Lass-Floerl C, Lee DG, Lehrnbecher T, Lmimouni BE, Mares M, Maschmeyer G, Meis JF, Meletiadis J, Morrissey CO, Nucci M, Oladele R, Pagano L, Pasqualotto A, Patel A, Racil Z, Richardson M, Roilides E, Ruhnke M, Seyedmousavi S, Sidharthan N, Singh N, Sinko J, Skiada A, Slavin M, Soman R, Spellberg B, Steinbach W, Tan BH, Ullmann AJ, Vehreschild JJ, Vehreschild M, Walsh TJ, White PL, Wiederhold NP, Zaoutis T, Chakrabarti A (2019). Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis. 2019 Dec;19(12):e405-e421. doi: 10.1016/S1473-3099(19)30312-3. Epub 2019 Nov 5   
  • Cheng MP, Lawandi A, Lee TC, Dufresne PJ, Seidel D, Verweij PE, Cornely OA, Sheppard DC (2019). Triazole Antifungal Susceptibility Patterns among Aspergillus Species in Quebec, Canada. J Clin Microbiol. 2019; 57(6)   
  • Buchta V, Bolehovska R, Hovorkova E, Cornely OA, Seidel D, Zak P (2019). Saprochaete clavata Invasive Infections - A New Threat to Hematological-Oncological Patients. Front Microbiol. 2019; 10: 2196    
  • Boch T, Spiess B, Heinz W, Cornely OA, Schwerdtfeger R, Hahn J, Krause SW, Duerken M, Bertz H, Reuter S, Kiehl M, Claus B, Deckert PM, Hofmann WK, Buchheidt D, Reinwald M (2019). Aspergillus specific nested PCR from the site of infection is superior to testing concurrent blood samples in immunocompromised patients with suspected invasive aspergillosis. Mycoses. 2019 Nov;62(11):1035-1042. doi: 10.1111/myc.12983  
  • Bassetti M, Giacobbe DR, Vena A, Trucchi C, Ansaldi F, Antonelli M, Adamkova V, Alicino C, Almyroudi MP, Atchade E, Azzini AM, Carannante N, Carnelutti A, Corcione S, Cortegiani A, Dimopoulos G, Dubler S, Garcia-Garmendia JL, Girardis M, Cornely OA, Ianniruberto S, Kullberg BJ, Lagrou K, Le Bihan C, Luzzati R, Malbrain M, Merelli M, Marques AJ, Martin-Loeches I, Mesini A, Paiva JA, Peghin M, Raineri SM, Rautemaa-Richardson R, Schouten J, Brugnaro P, Spapen H, Tasioudis P, Timsit JF, Tisa V, Tumbarello M, van den Berg C, Veber B, Venditti M, Voiriot G, Wauters J, Montravers P (2019). Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project. Crit Care. 2019 Jun 14;23(1):219. doi: 10.1186/s13054-019-2497-3  
  • Bacher P, Hohnstein T, Beerbaum E, Rocker M, Blango MG, Kaufmann S, Rohmel J, Eschenhagen P, Grehn C, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glosenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A (2019). Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans. Cell 2019 Mar 7;176(6):1340-1355.e15. doi: 10.1016/j.cell.2019.01.041. Epub 2019 Feb 21

Martin Denzel

  • Sawarkar R, Scherz-Shouval R, Denzel MS, Saarikangas J (2019). Chaperoning junior faculty: Institutional support and guidance can relieve challenges for early-career group leaders and improve academic performance. EMBO Rep. 2019 Jan;20(1). pii: e47163. doi: 10.15252/embr.201847163. Epub 2018 Nov 23  
  • Saez I, Gerbracht JV, Koyuncu S, Lee HJ, Horn M, Kroef V, Denzel MS, Dieterich C, Gehring NH, Vilchez D (2019). The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Lett. 2020 Jan;594(1):175-188. doi: 10.1002/1873-3468.13559. Epub 2019 Aug 8  
  • Horn M, Metge F, Denzel MS (2019). Unbiased Forward Genetic Screening with Chemical Mutagenesis to Uncover Drug-Target Interactions. Methods Mol Biol. 2019;1953:23-31. doi: 10.1007/978-1-4939-9145-7_2    

Sabine Eming

  • Kiesewetter A, Cursiefen C, Eming SA, Hos D (2019). Phase-specific functions of macropahges determine injury-medoated coneal hem- and lymphangiogenesis. Sci Rep 9:308  
  • Rongisch R, Haese S, Eming SA (2019). [38-year-old female with a treatment-resistant ulcer : Preparation for the specialist examination: part 48]. Hautarzt. 2019 Apr;70(Suppl 1):81-84. doi: 10.1007/s00105-019-4364-1  
  • Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA (2019). Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol. 2020 Jan;145(1):283-300.e8. doi: 10.1016/j.jaci.2019.07.033. Epub 2019 Aug 8  
  • Knipper JA, Ding X, Eming SA (2019). Diabetes Impedes the Epigenetic Switch of Macrophages into Repair Mode. Immunity. 2019 Aug 20;51(2):199-201. doi: 10.1016/j.immuni.2019.07.009

Mafalda Escobar-Henriques

  • Escobar-Henriques M, Joaquim M (2019). Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases. Front Physiol. 2019 May 9;10:517. doi: 10.3389/fphys.2019.00517. eCollection 2019 
  • Escobar-Henriques M, Altin S, Brave FD (2019). Interplay between the Ubiquitin Proteasome System and Mitochondria for Protein Homeostasis. Curr Issues Mol Biol. 2019 Aug 18;35:35-58. doi: 10.21775/cimb.035.035. [Epub ahead of print] 
  • Anton V, Buntenbroich I, Schuster R, Babatz F, Simões T, Altin S, Calabrese G, Riemer J, Schauss A, Escobar-Henriques M (2019). Plasticity in salt bridge allows fusion-competent ubiquitylation of  mitofusins and Cdc48 recognition. Life Sci Alliance. 2019 Nov 18;2(6). pii: e201900491. doi: 10.26508/lsa.201900491. Print 2019 Dec. PMID: 31740565

Ana J. Garcia-Saez  

  • Flores-Romero H, García-Sáez AJ (2019). The Incomplete Puzzle of the BCL2 Proteins. Cells. 2019 Sep 29;8(10). pii: E1176. doi: 10.3390/cells8101176. PMID: 31569576 
  • Teucher M, Zhang H, Bader V, Winklhofer KF, García-Sáez AJ, Rajca A, Bleicken S, Bordignon E (2019). A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labels. Sci Rep. 2019 Sep 10;9(1):13013. doi: 10.1038/s41598-019-49370-z. PMID: 31506457
  • Dimou E, Cosentino K, Platonova E, Ros U, Sadeghi M, Kashyap P, Katsinelos T, Wegehingel S, Noé F, García-Sáez AJ, Ewers H, Nickel W (2019). Single event visualization of unconventional secretion of FGF2. J Cell Biol. 2019 Feb 4;218(2):683-699. doi: 10.1083/jcb.201802008. PMID: 30470711
  • Flores-Romero H, Landeta O, Ugarte-Uribe B, Cosentino K, García-Porras M, García-Sáez AJ, Basañez G (2019). BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL. Cell Death Differ. 2019 Oct;26(10):1880-1894. doi: 10.1038/s41418-018-0258-5. PMID: 30560933
  • Danial JSH, Garcia-Saez AJ (2019). Quantitative analysis of super-resolved structures using ASAP. Nat Methods. 2019 Aug;16(8):711-714. doi: 10.1038/s41592-019-0472-1. PMID: 31263253
  • Singh PK, Roukounakis A, Weber A, Das KK, Sohm B, Villunger A, Garcia-Saez AJ, Häcker G (2019). Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim. Cell Death Differ. 2019 Jun 12. doi: 10.1038/s41418-019-0365-y. PMID: 31189926
  • Flores-Romero H, García-Sáez AJ (2019). MAVS-induced mitochondrial membrane remodeling. FEBS J. 2019 Apr;286(8):1540-1542. doi: 10.1111/febs.14822. PMID: 30957952
  • Dimou E, Cosentino K, Platonova E, Ros U, Sadeghi M, Kashyap P, Katsinelos T, Wegehingel S, Noé F, García-Sáez AJ, Ewers H, Nickel W (2019). Single event visualization of unconventional secretion of FGF2. J Cell Biol. 2019 Feb 4;218(2):683-699. doi: 10.1083/jcb.201802008. PMID: 30470711
  • Murad F, Garcia-Saez AJ (2019). Quantification of the Interactions Between BCL-2 Proteins by Fluorescence Correlation Spectroscopy. Methods Mol Biol. 2019;1877:337-350. doi: 10.1007/978-1-4939-8861-7_20. PMID: 30536014
  • Unsay JD, García-Sáez AJ (2019). AFM to Study Pore-Forming Proteins. Methods Mol Biol. 2019;1886:191-202. doi: 10.1007/978-1-4939-8894-5_10. PMID: 30374868

Martin Graef

  • Medeiros TC, Graef M (2019). Autophagy determines mtDNA copy number dynamics during starvation. Autophagy. 2019 Jan;15(1):178-179. doi: 10.1080/15548627.2018.1532263. Epub 2018 Oct 13  
  • Cui R, Medeiros T, Willemsen D, Isai LNM, Collier GE, Graef M, Reichard M, Valenzano DR (2019). Relaxed selection limits lifespan by increasing mutation load. Cell. 2019 Jul 11;178(2):385-399.e20. doi: 10.1016/j.cell.2019.06.004. Epub 2019 Jun 27

Michael Hallek

  • Al-Sawaf O, Bazeos A, Robrecht S, Bahlo J, Gower C, Fink AM, Tresckow J, Cramer P, Langerbeins P, Kutsch N, Humphrey K, Fingerle-Rowson G, Stilgenbauer S, Wendtner CM, Fischer K, Eichhorst B, Hallek M, Goede V (2019). Mode of progression after first line treatment correlates with outcome of chronic lymphocytic leukemia (CLL). Am J Hematol. 2019 Jun 20. doi: 10.1002/ajh.25561. [Epub ahead of print]  
  • Al-Sawaf O, Herling CD, Holtick U, Scheid C, Cramer P, Sasse S, von Tresckow B, Tuchscherer A, Fischer K, Eichhorst B, Hallek M, Frenzel LP (2019). Venetoclax plus rituximab or obinutuzumab after allogeneic hematopoietic stem cell transplantation in chronic lymphocytic leukemia. Haematologica. 2019 May;104(5):e224-e226. doi: 10.3324/haematol.2018.212837. Epub 2019 Feb 21  
  • Bachurski D, Schuldner M, Nguyen PH, Malz A, Reiners KS, Grenzi PC, Babatz F, Schauss AC, Hansen HP, Hallek M, Pogge von Strandmann E (2019). Extracellular vesicle measurements with nanoparticle tracking analysis - An accuracy and repeatability comparison between NanoSight NS300 and ZetaView. J Extracell Vesicles. 2019 Apr 1;8(1):1596016. doi: 10.1080/20013078.2019.1596016. eCollection 2019   
  • Baltin C, Kron F, Urbanski A, Zander T, Kron A, Berlth F, Kleinert R, Hallek M, Hoelscher AH, Chon SH (2019). The economic burden of endoscopic treatment for anastomotic leaks following oncological Ivor Lewis esophagectomy. PLoS One. 2019 Aug 28;14(8):e0221406. doi: 10.1371/journal.pone.0221406. eCollection 2019  
  • Bühl L, Abel T, Wolf F, Oberste M, Bloch W, Hallek M, Elter T, Zimmer P (2019). Feasibility and Potential Benefits of an Exercise Intervention in a Male With Down Syndrome Undergoing High-Dose Chemotherapy for Acute Lymphoblastic Leukemia: A Case Report. Integr Cancer Ther. 2019 Jan-Dec;18:1534735419832358. doi: 10.1177/1534735419832358  
  • Chmielewski M, Kuehle J, Chrobok D, Riet N, Hallek M, Abken H (2019). FimH-based display of functional eukaryotic proteins on bacteria surfaces. Sci Rep. 2019 Jun 10;9(1):8410. doi: 10.1038/s41598-019-44883-z  
  • Drößler L, Lehmann C, Töpelt K, Nierhoff D, Vehreschild JJ, Rybniker J, Hallek M, Fischer J, Stormberg V, Fätkenheuer G, Wieland U, Jung N (2019). HBsAg-negative/anti-HBc-positive patients treated with rituximab: prophylaxis or monitoring to prevent hepatitis B reactivation? Infection. 2019 Apr;47(2):293-300. doi: 10.1007/s15010-019-01271-z. Epub 2019 Jan 28   
  • Edelmann J, Holzmann K, Tausch E, Saunderson EA, Jebaraj BMC, Steinbrecher D, Dolnik A, Blätte TJ, Landau DA, Saub J, Estenfelder S, Ibach S, Cymbalista F, Leblond V, Delmer A, Bahlo J, Robrecht S, Fischer K, Goede V, Bullinger L, Wu CJ, Mertens D, Ficz G, Gribben JG, Hallek M, Döhner H, Stilgenbauer S (2019). Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1 regulated transcription. Haematologica. 2019 Aug 29. pii: haematol.2019.217307. doi: 10.3324/haematol.2019.217307. [Epub ahead of print]  
  • Eichenauer DA, Golla H, Thielen I, Hallek M, Voltz R, Perrar KM (2019). Characteristics and course of patients with advanced hematologic malignancies receiving specialized inpatient palliative care at a German university hospital. Ann Hematol. 2019 Nov;98(11):2605-2607. doi: 10.1007/s00277-019-03748-1. Epub 2019 Jun 28  
  • Fischer K, Al-Sawaf O, Bahlo J, Fink AM, Tandon M, Dixon M, Robrecht S, Warburton S, Humphrey K, Samoylova O, Liberati AM, Pinilla-Ibarz J, Opat S, Sivcheva L, Le Dû K, Fogliatto LM, Niemann CU, Weinkove R, Robinson S, Kipps TJ, Boettcher S, Tausch E, Humerickhouse R, Eichhorst B, Wendtner CM, Langerak AW, Kreuzer KA, Ritgen M, Goede V, Stilgenbauer S, Mobasher M, Hallek M (2019). Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions. N Engl J Med. 2019 Jun 6;380(23):2225-2236. doi: 10.1056/NEJMoa1815281. Epub 2019 Jun 4   
  • Fischer K, Ritgen M, Al-Sawaf O, Robrecht S, Tandon M, Fink AM, Schilhabel A, Stübig T, Brüggemann M, Jiang Y, Schary W, Eichhorst BF, Wendtner CM, Tausch E, Kreuzer KA, Langerak AW, Goede V, Böttcher S, Stilgenbauer S, Kneba M, Hallek M (2019). Quantitative Analysis of Minimal Residual Disease (MRD) Shows High Rates of Undetectable MRD after Fixed-Duration Chemotherapy-Free Treatment and Serves As Surrogate Marker for Progression-Free Survival: A Prospective Analysis of the Randomized CLL14 Trial. Blood. 2019 Nov 13;134(Supplement_1):36. doi: 10.1182/blood-2019-125825   
  • Fraser G, Cramer P, Demirkan F, Silva RS, Grosicki S, Pristupa A, Janssens A, Mayer J, Bartlett NL, Dilhuydy MS, Pylypenko H, Loscertales J, Avigdor A, Rule S, Villa D, Samoilova O, Panagiotidis P, Goy A, Pavlovsky MA, Karlsson C, Hallek M, Mahler M, Salman M, Sun S, Phelps C, Balasubramanian S, Howes A, Chanan-Khan A (2019). Updated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma. Leukemia. 2019 Apr;33(4):969-980. doi: 10.1038/s41375-018-0276-9. Epub 2018 Oct 12  
  • Fürstenau M, Bahlo J, Fink AM, Lange E, Dreger P, Dreyling M, Hess G, Ritgen M, Kneba M, Döhner H, Stilgenbauer S, Wendtner CM, Goede V, Fischer K, Böttcher S, Hallek M, Eichhorst B (2019). Residual abdominal lymphadenopathy after intensive frontline chemoimmunotherapy is associated with inferior outcome independently of minimal residual disease status in chronic lymphocytic leukemia. Leukemia. 2019 Oct 14. doi: 10.1038/s41375-019-0597-3. [Epub ahead of print]   
  • Fürstenau M, Hopfinger G, Robrecht S, Fink AM, Al-Sawaf O, Langerbeins P, Cramer P, Tresckow JV, Maurer C, Kutsch N, Hoechstetter M, Dreyling M, Lange E, Kneba M, Stilgenbauer S, Döhner H, Hensel M, Kiehl MG, Jaeger U, Wendtner CM, Goede V, Fischer K, Bergwelt MV, Eichhorst B, Hallek M, Theurich S (2019). Influence of obesity and gender on treatment outcomes in patients with chronic lymphocytic leukemia (CLL) undergoing rituximab-based chemoimmunotherapy. Leukemia. 2019 Nov 14. doi: 10.1038/s41375-019-0630-6. [Epub ahead of print]  
  • Hallek M (2019).Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment. Am J Hematol. 2019 Nov;94(11):1266-1287. doi: 10.1002/ajh.25595. Epub 2019 Oct 4  
  • Hallek M, Haller H (2019). [Multiple myeloma]. Internist (Berl). 2019 Jan;60(1):1-2. doi: 10.1007/s00108-018-0553-8. German  
  • Herling CD, Coombes KR, Benner A, Bloehdorn J, Barron LL, Abrams ZB, Majewski T, Bondaruk JE, Bahlo J, Fischer K, Hallek M, Stilgenbauer S, Czerniak BA, Oakes CC, Ferrajoli A, Keating MJ, Abruzzo LV (2019). Sequential and combination treatments with novel agents in chronic lymphocytic leukemia. Time-to-progression after front-line fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy for chronic lymphocytic leukaemia: a retrospective, multicohort study. Lancet Oncol. 2019 Nov;20(11):1576-1586. doi: 10.1016/S1470-2045(19)30503-0. Epub 2019 Sep 30  
  • Jebaraj BMC, Tausch E, Landau DA, Bahlo J, Robrecht S, Taylor-Weiner AN, Bloehdorn J, Scheffold A, Mertens D, Böttcher S, Kneba M, Jäger U, Zenz T, Wenger MK, Fingerle-Rowson G, Wendtner C, Fink AM, Wu CJ, Eichhorst B, Fischer K, Hallek M, Döhner H, Stilgenbauer S (2019). Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia. Leukemia. 2019 Sep;33(9):2183-2194. doi: 10.1038/s41375-019-0446-4. Epub 2019 Mar 25   
  • Kipps TJ, Fraser G, Coutre SE, Brown JR, Barrientos JC, Barr PM, Byrd JC, O'Brien SM, Dilhuydy MS, Hillmen P, Jaeger U, Moreno C, Cramer P, Stilgenbauer S, Chanan-Khan AA, Mahler M, Salman M, Eckert K, Solman IG, Balasubramanian S, Cheng M, Londhe A, Ninomoto J, Howes A, James DF, Hallek M (2019). Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia. Clin Lymphoma Myeloma Leuk. 2019 Jul 15. pii: S2152-2650(19)30398-2. doi: 10.1016/j.clml.2019.07.004. [Epub ahead of print]  
  • Kreuzer KA, Furman RR, Stilgenbauer S, Dubowy RL, Kim Y, Munugalavadla V, Lilienweiss E, Reinhardt HC, Cramer P, Eichhorst B, Hillmen P, O'Brien SM, Pettitt AR, Hallek M (2019). The impact of complex karyotype on the overall survival of patients with relapsed chronic lymphocytic leukemia treated with idelalisib plus rituximab. Leukemia. 2019 Aug 19. doi: 10.1038/s41375-019-0533-6. [Epub ahead of print]  
  • Kurtz DM, Esfahani MS, Scherer F, Soo J, Jin MC, Liu CL, Newman AM, Dührsen U, Hüttmann A, Casasnovas O, Westin JR, Ritgen M, Böttcher S, Langerak AW, Roschewski M, Wilson WH, Gaidano G, Rossi D, Bahlo J, Hallek M, Tibshirani R, Diehn M, Alizadeh AA (2019). Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction. Cell. 2019 Jul 25;178(3):699-713.e19. doi: 10.1016/j.cell.2019.06.011. Epub 2019 Jul 4  
  • Langerak AW, Ritgen M, Goede V, Robrecht S, Bahlo J, Fischer K, Steurer M, Trněný M, Mulligan SP, Mey UJM, Trunzer K, Fingerle-Rowson G, Humphrey K, Stilgenbauer S, Böttcher S, Brüggemann M, Hallek M, Kneba M, van Dongen JJM (2019). Prognostic value of MRD in CLL patients with comorbidities receiving chlorambucil plus obinutuzumab or rituximab. Blood. 2019 Jan 31;133(5):494-497. doi: 10.1182/blood-2018-03-839688. Epub 2018 Nov 19  
  • Pflug N, Cramer P, Robrecht S, Bahlo J, Westermann A, Fink AM, Schrader A, Mayer P, Oberbeck S, Seiler T, Zenz T, Dürig J, Kreuzer KA, Stilgenbauer S, Eichhorst B, Hallek M, Herling M, Hopfinger G (2019). New lessons learned in T-PLL: results from a prospective phase-II trial with fludarabine-mitoxantrone-cyclophosphamide-alemtuzumab induction followed by alemtuzumab maintenance. Leuk Lymphoma. 2019 Mar;60(3):649-657. doi: 10.1080/10428194.2018.1488253. Epub 2018 Sep 20  
  • Ram R, Scheid C, Amit O, Chemnitz JM, Moshe Y, Hallek M, Wolf D, Avivi I, Holtick U (2019). Sequential therapy for patients with primary refractory acute myeloid leukemia: a historical prospective analysis of the German and Israeli experience. Haematologica. 2019 Sep;104(9):1798-1803. doi: 10.3324/haematol.2018.203869. Epub 2019 Feb 7   
  • Rice C, Eikema DJ, Marsh JCW, Knol C, Hebert K, Putter H, Peterson E, Deeg HJ, Halkes S, Pidala J, Anderlini P, Tischer J, Kroger N, McDonald A, Antin JH, Schaap NP, Hallek M, Einsele H, Mathews V, Kapoor N, Boelens JJ, Mufti GJ, Potter V, Pefault de la Tour R, Eapen M, Dufour C (2019). Allogeneic Hematopoietic Cell Transplantation in Patients Aged 50Years or Older with Severe Aplastic Anemia. Biol Blood Marrow Transplant. 2019 Mar;25(3):488-495. doi: 10.1016/j.bbmt.2018.08.029. Epub 2018 Sep 5  
  • Roberts AW, Ma S, Kipps TJ, Coutre SE, Davids MS, Eichhorst B, Hallek M, Byrd JC, Humphrey K, Zhou L, Chyla B, Nielsen J, Potluri J, Kim SY, Verdugo M, Stilgenbauer S, Wierda WG, Seymour JF (2019). Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables. Blood. 2019 Jul 11;134(2):111-122. doi: 10.1182/blood.2018882555. Epub 2019 Apr 25  
  • Rossi A, Dupaty L, Aillot L, Zhang L, Gallien C, Hallek M, Odenthal M, Adriouch S, Salvetti A, Büning H (2019). Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity.Sci Rep. 2019 Mar 6;9(1):3631. doi: 10.1038/s41598-019-40071-1  
  • Sachanas S, Pangalis GA, Fink AM, Bahlo J, Fischer K, Levidou G, Kyrtsonis MC, Bartzi V, Vassilakopoulos TP, Kalpadakis C, Koulieris E, Moschogiannis M, Yiakoumis X, Tsirkinidis P, Angelopoulou MK, Eichhorst B, Hallek M (2019). Small Lymphocytic Lymphoma: Analysis of Two Cohorts Including Patients in Clinical Trials of the German Chronic Lymphocytic Leukemia Study Group (GCLLSG) or in "Real-Life" Outside of Clinical Trials. Anticancer Res. 2019 May;39(5):2591-2598. doi: 10.21873/anticanres.13382   
  • Schetelig J, Link CS, Stuhler G, Wagner EM, Hänel M, Kobbe G, Böttcher S, Kreuzer KA, Middeke JM, Sockel K, Teipel R, von Bonin M, Stölzel F, Kramer M, Stilgenbauer S, Hallek M, Bornhäuser M; Deutsche CLL Studiengruppe and the German Cooperative Transplant Study Group (2019). Anti-CD20 immunotherapy as a bridge to tolerance, after allogeneic stem cell transplantation for patients with chronic lymphocytic leukaemia: results of the CLLX4 trial. Br J Haematol. 2019 Mar;184(5):833-836. doi: 10.1111/bjh.15181. Epub 2018 Mar 12   
  • Schuldner M, Dörsam B, Shatnyeva O, Reiners KS, Kubarenko A, Hansen HP, Finkernagel F, Roth K, Theurich S, Nist A, Stiewe T, Paschen A, Knittel G, Reinhardt HC, Müller R, Hallek M, von Strandmann EP (2019). Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53. Theranostics. 2019 Aug 14;9(21):6047-6062. doi: 10.7150/thno.36378. eCollection 2019   
  • Sharman JP, Coutre SE, Furman RR, Cheson BD, Pagel JM, Hillmen P, Barrientos JC, Zelenetz AD, Kipps TJ, Flinn IW, Ghia P, Eradat H, Ervin T, Lamanna N, Coiffier B, Pettitt AR, Ma S, Tausch E, Cramer P, Huang J, Mitra S, Hallek M, O'Brien SM, Stilgenbauer S (2019). Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia. J Clin Oncol. 2019 Jun 1;37(16):1391-1402. doi: 10.1200/JCO.18.01460. Epub 2019 Apr 17   
  • Soumerai JD, Ni A, Xing G, Huang J, Furman RR, Jones J, Sharman JP, Hallek M, Adewoye AH, Dubowy R, Dreiling L, Zelenetz AD (2019). Evaluation of the CLL-IPI in relapsed and refractory chronic lymphocytic leukemia in idelalisib phase-3 trials. Leuk Lymphoma. 2019 Jun;60(6):1438-1446. doi: 10.1080/10428194.2018.1540782. Epub 2018 Nov 8   
  • von Tresckow J, Cramer P, Bahlo J, Robrecht S, Langerbeins P, Fink AM, Al-Sawaf O, Illmer T, Klaproth H, Estenfelder S, Ritgen M, Fischer K, Wendtner CM, Kreuzer KA, Stilgenbauer S, Böttcher S, Eichhorst BF, Hallek M (2019). CLL2-BIG: sequential treatment with bendamustine, ibrutinib and obinutuzumab (GA101) in chronic lymphocytic leukemia. Leukemia. 2019 May;33(5):1161-1172. doi: 10.1038/s41375-018-0313-8. Epub 2018 Dec 19

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Matthias Hammerschmidt

  • Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC (2019). CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031

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Robert Hansel-Hertsch  

  • Krafcikova M, Dzatko S, Caron C, Granzhan A, Fiala R, Loja T, Teulade-Fichou MP, Fessl T, Hänsel-Hertsch R, Mergny JL, Foldynova-Trantirkova S, Trantirek L (2019). Monitoring DNA-Ligand Interactions in Living Human Cells Using NMR Spectroscopy. J Am Chem Soc. (2019), 34: 13281-13285
  • Krafcikova M, Hänsel-Hertsch R, Trantirek L, Foldynova-Trantirkova S (2019). In Cell NMR Spectroscopy: Investigation of G-Quadruplex Structures Inside Living Xenopus laevis Oocytes. Methods Mol Biol. 2019;2035:397-405. doi: 10.1007/978-1-4939-9666-7_25

Jan Hoeijmakers 

  • Alyodawi K, Vermeij WP, Omairi S, Kretz O, Hopkinson M, Solagna F, Joch B, Brandt RMC, Barnhoorn S, van Vliet N, Ridwan Y, Essers J, Mitchell R, Morash T, Pasternack A, Ritvos O, Matsakas A, Collins-Hooper H, Huber TB, Hoeijmakers JHJ, Patel K (2019). Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling. J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):662-686. doi: 10.1002/jcsm.12404. Epub 2019 Mar 27. PMID: 30916493
  • Jager M, Blokzijl F, Kuijk E, Bertl J, Vougioukalaki M, Janssen R, Besselink N, Boymans S, de Ligt J, Pedersen JS, Hoeijmakers J, Pothof J, van Boxtel R, Cuppen E (2019). Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer. Genome Res. 2019 Jul;29(7):1067-1077. doi: 10.1101/gr.246223.118. Epub 2019 Jun 20  
  • Theil AF, Botta E, Raams A, Smith DEC, Mendes MI, Caligiuri G, Giachetti S, Bione S, Carriero R, Liberi G, Zardoni L, Swagemakers SMA, Salomons GS, Sarasin A, Lehmann A, van der Spek PJ, Ogi T, Hoeijmakers JHJ, Vermeulen W, Orioli D (2019). Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype. Am J Hum Genet. 2019 Aug 1;105(2):434-440. doi: 10.1016/j.ajhg.2019.06.017. PMID: 31374204  
  • Lans H, Hoeijmakers JHJ, Vermeulen W, Marteijn JA (2019). The DNA damage response to transcription stress. Nat Rev Mol Cell Biol. 2019 Sep 26. doi: 10.1038/s41580-019-0169-4. [Epub ahead of print] PMID: 31558824  
  • Milanese C, Bombardieri CR, Sepe S, Barnhoorn S, Payán-Goméz C, Caruso D, Audano M, Pedretti S, Vermeij WP, Brandt RMC, Gyenis A, Wamelink MM, de Wit AS, Janssens RC, Leen R, van Kuilenburg ABP, Mitro N, Hoeijmakers JHJ, Mastroberardino PG (2019). DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering. Nat Commun. 2019 Oct 25;10(1):4887. doi: 10.1038/s41467-019-12640-5. PMID: 31653834  
  • Kim DE, Dollé MET, Vermeij WP, Gyenis A, Vogel K, Hoeijmakers JHJ, Wiley CD, Davalos AR, Hasty P, Desprez PY, Campisi J (2019). Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. Aging Cell. 2019 Nov 18:e13072. doi: 10.1111/acel.13072. [Epub ahead of print] PMID: 31737985

Thorsten Hoppe       

  • Finger F, Ottens F, Springhorn A, Drexel T, Proksch L, Metz S, Cochella L, Hoppe T (2019). Olfaction regulates organismal proteostasis and longevity via miRNA-dependent signaling. Nat. Metab. (in press)          
  • Springhorn A, Hoppe T (2019). Western blot analysis of the autophagosomal membrane protein LGG-1/LC3 in Caenorhabditis elegans. Method Enzymol. 2019;619:319-336. doi: 10.1016/bs.mie.2018.12.034. Epub 2019 Feb 4     
  • Herzog LK, Kevei É, Marchante R, Böttcher C, Bindesbøll C, Lystad AH, Pfeiffer A, Gierisch ME, Salomons FA, Simonsen A, Hoppe T, Dantuma NP (2019). The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy. Aging Cell. 2019 Oct 17:e13051. doi: 10.1111/acel.13051. [Epub ahead of print]    
  • Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB. Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, Hoppe T, Kaeberlein M, Katajisto P, Kennedy BK, Lal U, Martin-Villalba A, Moskalev AA, Ozerov I, Petr MA, Reason, Rubinsztein DC, Tyshkovskiy A, Vanhaelen Q, Zhavoronkov A, Scheibye-Knudsen M (2019). Latest advances in aging research and drug discovery. Aging-US. 2019 Nov 21;11. doi: 10.18632/aging.102487. [Epub ahead of print]     
  • Ottens F, Finger F, Hoppe T (2019). Wie der Geruch von Nahrung Stoffwechsel und Altern beeinflusst. Nutrition News 3, 3-5.

Tamas Horvath      

  • Stutz B, Nasrallah C, Nigro M, Curry D, Liu ZW, Gao XB, Elsworth JD, Mintz L, Horvath TL (2019). Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Mol Metab. 2019 Jun;24:120-138. doi: 10.1016/j.molmet.2019.02.005. Epub 2019 Feb 21
  • Seli E, Wang T, Horvath TL (2019). Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertil Steril. 2019 Feb;111(2):197-204. doi: 10.1016/j.fertnstert.2018.11.048

Pitter Huesgen  

  • Niedermaier S, Huesgen PF (2019). Positional proteomics for identification of secreted proteoforms released by site-specific membrane protein processing. Biochim Biophys Acta Proteins Proteom, 2019 Dec;1867(12):140138. doi: 10.1016/j.bbapap.2018.09.004. Epub 2018 Sep 20  
  • Weng SSH, Demir F, Ergin EK, Dirnberger S, Uzozie A, Tuscher D, Nierves L, Tsui J, Huesgen PF, Lange PF (2019). Sensitive determination of proteolytic proteoforms in limited microscale proteome samples. Mol Cell Proteomics. 2019 Nov;18(11):2335-2347. doi: 10.1074/mcp.TIR119.001560. Epub 2019 Aug 30  
  • Huber CV, Jakobs B, Mishra LS, Niedermaier S, Stift M, Winter G, Adamska I, Funk C, Huesgen PF, Funck D (2019). DEG10 is important for mitochondrial proteostasis, root growth and seed yield in Arabidopsis. J Exp Bot. 2019 Oct 15;70(19):5423-5436. doi: 10.1093/jxb/erz294  
  • Misas-Villamil J, Mueller AN, Demir F, Meyer U, Breuer M, Dauben H, Win J, Huesgen PF, Doehlemann G (2019). The fungal effector Pit2 acts as molecular mimicry to suppress plant immunity via an inter-kingdom conserved motif. Nat Commun.10:1576  
  • Krichel C, Möckel C, Schillinger O, Huesgen PF, Sticht H, Strodel B, Weiergräber OH, Willbold D, Neudecker P (2019). Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site. Sci Rep. 9:14167  
  • Zelanis A, Oliveira AK, Prudova A, Huesgen PF, Tashima AK, Kizhakkedathu JN, Overall CM, de Toledo Serrano SM (2019). Deep profiling of the cleavage specificity and human substrates of snake venom metalloprotease HF3 by PICS using proteome derived peptide libraries and TAILS N-terminomics. J Proteome Res. 18:3419-28  
  • Drescher HK, Weiskirchen R, Fülöp A, Hopf C, de San Román EG, Huesgen PF, de Bruin A, Bongiovanni L, Christ A, Tolba R, Trautwein C, Kroy DC (2019). The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH). Front Physiol. 10:770  
  • Elfgen A, Hupert M, Bochinsky K, Tusche M, González de San Román Martin E, Gering I, Sacchi S, Pollegioni L, Huesgen PF, Hartmann R, Santiago-Schübel B, Kutzsche J, Willbold D (2019). Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers. Sci Rep. 9:5715  
  • Perrar A, Dissmeyer N, Huesgen PF (2019). New beginnings and new ends – Methods for large-scale characterization of protein termini and their use in plant biology. J Exp Bot. 70:2021-38  
  • Soares A, Niedermaier S, Faro R, Loos A, Manadas B, Faro C, Huesgen PF, Cheung AY, Simões I (2019). An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana. J Exp Bot. 70:2157-71  
  • Dahms SO, Demir F, Huesgen PF, Thorn K, Brandstetter H (2019). Sirtilins - the new old members of the vitamin K-dependent coagulation factor family. J Thromb Haemost, 17:470-81  
  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM (2019). The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. 95:333-49  
  • Demir F, Perrar A, Huesgen PF (2019) Das maßgeschneiderte Proteom: Proteinmodifikation durch Proteolyse. BIOspektrum. 25:41-44

Sandra Iden

  • Dias Gomes M, Letzian S, Saynisch M, Iden S (2019). Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity. Nat Commun. 2019; 10: 3362. Published online 2019 Jul 29. doi: 10.1038/s41467-019-11325-3

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Frank Jessen

  • Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L,  Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT Jr, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall  DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Caltagirone C, Bossù P, Orfei MD, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Slifer S, Seeley WW, Smith AG,  Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Saba Y; Alzheimer Disease Genetics Consortium (ADGC),; European Alzheimer’s Disease Initiative (EADI),; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),; Genetic and Environmental Risk inAD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),, Pilotto A, Bullido MJ, Peters O, Crane PK, BennettD, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL,Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM,Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG, Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, C O'Donovan M, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA (2019). Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019 Mar;51(3):414-430. doi:10.1038/s41588-019-0358-2. Epub 2019 Feb 28. PubMed PMID: 30820047
  • Escher CM, Sannemann L, Jessen F (2019). Stress and Alzheimer's disease. J Neural Transm (Vienna). 2019 Feb 20. doi: 10.1007/s00702-019-01988-z. [Epub ahead of print]
  • Dalmasso MC, Brusco LI, Olivar N, Muchnik C, Hanses C, Milz E, Becker J, Heilmann-Heimbach S, Hoffmann P, Prestia FA, Galeano P, Avalos MSS, Martinez LE, Carulla ME, Azurmendi PJ, Liberczuk C, Fezza C, Sampaño M, Fierens M, Jemar G, Solis P, Medel N, Lisso J, Sevillano Z, Bosco P, Bossù P, Spalletta G, Galimberti D, Mancuso M, Nacmias B, Sorbi S, Mecocci P, Pilotto A, Caffarra P, Panza F, Bullido M, Clarimon J, Sánchez-Juan P, Coto E, Sanchez-Garcia F, Graff C, Ingelsson M, Bellenguez C, Castaño EM, Kairiyama C, Politis DG, Kochen S, Scaro H, Maier W, Jessen F, Mangone CA, Lambert JC, Morelli L, Ramirez A (2019). Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease. Transl Psychiatry. 2019 Jan 31;9(1):55. doi: 10.1038/s41398-019-0394-9. PubMed PMID: 30705288; PubMed Central PMCID: PMC6355764
  • Haidl TK, Seves M, Eggers S, Rostamzadeh A, Genske A, Jünger S, Woopen C, Jessen F, Ruhrmann S, Vogeley K (2019). Health literacy in clinical-high-risk individuals for psychosis: A systematic mixed-methods review. Early Interv Psychiatry. 2019 Jan 27. doi: 10.1111/eip.12776. [Epub ahead of print] Review. PubMed PMID: 30688012
  • Jessen F (2019). Early detection of Alzheimer's disease and approaches for prevention. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Jan 24. doi: 10.1007/s00103-019-02877-2. [Epub ahead of print] Review. German. PubMed PMID: 30680409
  • Wolfsgruber S, Molinuevo JL, Wagner M, Teunissen CE, Rami L, Coll-Padrós N, Bouwman FH, Slot RER, Wesselman LMP, Peters O, Luther K, Buerger K, Priller J, Laske C, Teipel S, Spottke A, Heneka MT, Düzel E, Drzezga A, Wiltfang J, Sikkes SAM, van der Flier WM, Jessen F, Euro-SCD working group (2019). Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples. Alzheimers Res Ther. 2019 Jan 17;11(1):8. doi: 10.1186/s13195-018-0463-y. PubMed PMID: 30654834; PubMed Central PMCID: PMC6337830
  • Jagust W, Jack CR Jr, Bennett DA, Blennow K, Haeberlein SB, Holtzman DM, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Sperling R (2019). "Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia". Alzheimers Dement. 2019 Jan;15(1):153-157. doi: 10.1016/j.jalz.2018.11.002. PubMed PMID: 30642435
  • Meiberth D, Rapp MA, Jessen F (2019). Memory Clinics in Germany - Results of a Hospital Survey. Psychiatr Prax. 2019 Jan 14. doi: 10.1055/a-0825-9049. [Epub ahead of print] German. PubMed PMID: 30641612
  • Schüller CB, Kuhn J, Jessen F, Hu X (2019). Neuronal correlates of delay discounting in healthy subjects and its implication for addiction: an ALE meta-analysis study. Am J Drug Alcohol Abuse. 2019;45(1):51-66. doi:10.1080/00952990.2018.1557675. Epub 2019 Jan 11. PubMed PMID: 30632802

Hamid Kashkar

  • Habich M, Salscheider S, Murschall L, Hoehne M, Fischer M, Schorn F, Petrungaro C, Ali M, Erdogan A, Abou-Eid S, Kashkar H, Dengjel J, Riemer J (2019). Vectorial import via a metastable disulphide-linked complex allows for a quality control step and efficient import by the mitochondrial disulphide relay Cell Rep. 2019 Jan 15;26(3):759-774.e5. doi: 10.1016/j.celrep.2018.12.092 
  • Schiffmann LM, Fritsch M, Gebauer F, Günther SD, Stair NR, Seeger JM, Thangarajah F, Dieplinger G, Bludau M, Alakus H, Göbel H, Quaas A, Zander T, Hilberg F, Bruns CJ, Kashkar H, Coutelle O (2019). Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer. Br J Cancer. 2019 Jan;120(1):69-78. doi: 10.1038/s41416-018-0198-3. Epub 2018 Oct 31  
  • Gräb J, Suarez I, van Gumpel E, Winter S, Schreiber F, Esser A, Hölscher C, Fritsch M, Herb M, Schramm M, Wachsmuth L, Pallasch C, Pasparakis M, Kashkar H, Rybniker J (2019). Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition. Nat Commun. 10:688   
  • Ayachi O, Barlin M, Broxtermann PN, Kashkar H, Mauch C, Zigrino P (2019). The X-linked inhibitor of apoptosis protein (XIAP) is involved in melanoma invasion by regulating cell migration and survival. Cell Oncol. 42:319-329   
  • Holzer T, Probst K, Etich J, Auler M, Georgieva V, Bluhm B, Frie C, Heilig J, Niehoff A, Nüchel J, Plomann M, Seeger JM, Kashkar H, Baris OR, Wiesner RJ, Brachvogel B (2019). Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases. J Cell Biol. 218(6):1853-1870   
  • Schiffmann LM, Göbel H, Löser H, Schorn F, Werthenbach JP, Fuchs HF, Plum PS, Bludau M, Zander T, Schröder W, Bruns CJ, Kashkar H, Quaas A, Gebauer F. (2019). Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma. BMC Cancer. 2019, 19(1):531   
  • Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H (2019). Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature. 2019, 575:683-687

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Peter Kloppenburg

  • Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI (2019). Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. 2019 Aug;67(8):1526-1541. doi: 10.1002/glia.23626. Epub 2019 Apr 16
  • Benkert J, Hess S, Roy S, Beccano-Kelly D, Wiederspohn N, Duda J, Simons C, Patil K, Gaifullina A, Mannal N, Dragicevic E, Spaich D, Müller S, Nemeth J, Hollmann H, Deuter N, Mousba Y, Kubisch C, Poetschke C, Striessnig J, Pongs O, Schneider T, Wade-Martins R, Patel S, Parlato R, Frank T, Kloppenburg P, Liss B (2019). Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease. Nat Commun. 2019 Nov 8;10(1):5094. doi: 10.1038/s41467-019-12834-x. PMID: 31704946  
  • Vogel S, Schäfer C, Hess S, Folz-Donahue K, Nelles M, Minassian A, Schwarz MK, Kukat C, Ehrlich M, Zaehres H, Kloppenburg P, Hoehn M, Aswendt M (2019). The in vivo timeline of differentiation of engrafted human neural progenitor cells. Stem Cell Res. 2019 May;37:101429. doi: 10.1016/j.scr.2019.101429. Epub 2019 Mar 25. PMID: 30933718   

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Natalia Kononenko

  • Upadhyay A, Hosseinibarkooie M, Schneider S, Kaczmarek A, Torres-Benito L, Natalia Mendoza-Ferreira N, Overhoff M, Rombo R, Grysko V, Kye MJ, Kononenko NL, Wirth B (2019). Neurocalcin delta knockout impairs adult neurogenesis whereas half reduction is a safe therapeutic option for spinal muscular atrophy. Front Mol Neurosci. 2019 Feb 12. doi: 10.3389/fnmol.2019.00019
  • Kononenko NL, Hartfil S, Willer J, Ferch J, Wolfenberg H, Pflueger HJ (2019). A population of descending tyraminergic/octopaminergic projection neurons of the insect. J Comp Neurol. Apr 15;527:1027-1038 (2019)  
  • Torres-Benito L, Schneider S, Rombo R, Ling KK, Grysko V, Upadhyay A, Kononenko NL, Rigo FW, Bennett CF, Wirth B (2019). NCALD antisense oligonucleotide-based therapy additionally to low-dose Nusinersen further ameliorates spinal muscular atrophy in mice. Am J Hum Genet. 2019 Jul 3;105(1):221-230. doi: 10.1016/j.ajhg.2019.05.008. Epub 2019 Jun 20

Martin Krönke

  • Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H (2019). Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature. 2019 Nov;575(7784):683-687. doi: 10.1038/s41586-019-1770-6. Epub 2019 Nov 20

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Marcus Krüger

  • Jachimowicz RD, Bhavana VB, Beleggia F, Isensee J, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y(2019). UBQLN4 regulates double-strand break repair by repressing homologous recombination and is overexpressed in aggressive tumors, Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3   
  • Steiner C, Nolte H, Azizan A, Krüger M, Denecke M, Rehorek A (2019). Quantitative proteomics for monitoring microbial dynamics in activated sludge from landfill leachate treatment. Environ Sci. : Water Res. Technol. 5(6), 1092-1101    
  • Frank D, Yusuf Rangrez A, Friedrich C, Dittmann S, Stallmeyer B, Yadav P, Bernt A, Schulze-Bahr E, Borlepawar A, Zimmermann WH, Peischard S, Seebohm G, Linke WA, Baba HA, Krüger M, Unger A, Usinger P, Frey N, Schulze-Bahr E (2019). Cardiac α-Actin (ACTC1) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy. Circ Genom Precis Med. 2019 Aug;12(8):e002491. doi: 10.1161/CIRCGEN.119.002491. Epub 2019 Aug 20   
  • Klapproth S, Bromberger T, Türk C, Krüger M, Moser M (2019). A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability. J Cell Biol. 2019 Oct 7;218(10):3436-3454. doi: 10.1083/jcb.201903109. Epub 2019 Sep 19   
  • Rehorst WA, Thelen MP, Nolte H, Türk C, Cirak S, Peterson JM, Wong GW, Wirth B, Krüger M, Winter D, Kye MJ (2019). Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy. Acta Neuropathol Commun. 2019 Oct 15;7(1):154. doi: 10.1186/s40478-019-0806-3   
  • Baraldo M, Geremia A, Pirazzini M, Nogara L, Solagna F, Türk C, Nolte H, Romanello V, Megighian A, Boncompagni S, Krüger M, Sandri M, Blaauw B (2019). Skeletal muscle mTORC1 regulates neuromuscular junction stability. J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):208-225. doi: 10.1002/jcsm.12496. Epub 2019 Oct 25
  • MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Krüger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Brüning JC, Zamboni N, Langer T (2019). Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature. 2019 Nov;575(7782):361-365. doi: 10.1038/s41586-019-1738-6. Epub 2019 Nov 6   
  • Saul VV, Seibert M, Krüger M, Jeratsch S, Kracht M, Schmitz ML (2019). ULK1/2 restricts the formation of inducible SINT-speckles, a new class of membrane-less organelles controlling the threshold of TBK1 activation. iScience. 19, 527-44   
  • Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Parkitna JR, Brüning JC (2019). The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. Cell Rep. 27(11), 3182-198   
  • Hammerschmidt P, Ostkotte D, Nolte H, Gerl MJ, Jais A, Brunner H, Sprenger HG, Awazawa M, Nicholls HAT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC (2019). CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell. 2019 May 30;177(6):1536-1552.e23. doi: 10.1016/j.cell.2019.05.008   
  • Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG Schmitz ML (2019). CDK1-mediated phosphorylation at the novel histone modification site H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi: 10.1083/jcb.201806057. Epub 2019 Feb 14   
  • Gärtner S, Hundertmark T, Nolte H, Theofel I, Eren-Ghiani Z, Tetzner C, Duchow TB, Rathke C, Krüger M, Renkawitz-Pohl R (2019). Stage-specific testes proteomics of Drosophila melanogaster identifies essential proteins for male fertility. Eur J Cell Biol. 2019 Jun;98(2-4):103-115. doi: 10.1016/j.ejcb.2019.01.001. Epub 2019 Jan 17

Leo Kurian

  • Frank S, Ahuja G, Bartsch D, Russ N, Yao W,  Kuo JC, Derks JP,  Akhade VS, Kargapolova Y, Georgomanolis T, Messling J, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L (2019). yylncT defines a class of divergently-transcribed lncRNAs and safeguards the T-mediated mesodermal commitment of human PSCs. Cell Stem Cell. 2019 Feb 7;24(2):318-327.e8. doi: 10.1016/j.stem.2018.11.005. Epub 2018 Dec 13      
  • Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling J,Dodzian J, Lehmann K, Vargas N, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano D, Kurian L (2019). Loss of genomic integrity by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep. 2019 Apr;20(4). pii: e47407. doi: 10.15252/embr.201847407. Epub 2019 Mar 18            
  • Kuo CC, Hanzelmann S, Sentürk N, Frank S, Zajzon B, Derks JP, Akhade VS, Ahuja G, Kanduri C, Grummt I, Kurian L, Costa IG (2019).  Detection of RNA–DNA binding sites in long noncoding RNAs. Nucleic Acids Res. 2019 Apr 8;47(6):e32. doi: 10.1093/nar/gkz037         
  • Bender D, Kaczmarek AT, Santamaria-Araujo JA, Stueve B, Waltz S, Bartsch D, Kurian L, Cirak S, Schwarz G (2019). Impaired mitochondrial maturation of sulfite oxidase in a patient with severe sulfite oxidase deficiency. Hum Mol Genet. 2019 Sep 1;28(17):2885-2899. doi: 10.1093/hmg/ddz109

Thomas Langer

  • Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI (2019). Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. 2019 Aug;67(8):1526-1541. doi: 10.1002/glia.23626. Epub 2019 Apr 16
  • Miliara X, Tatsuta T, Berry JL, Rouse SL, Solak K, Chorev DS, Wu D, Robinson CV, Matthews S, Langer T (2019). Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins. Nat Commun. 2019 Mar 8;10(1):1130. doi: 10.1038/s41467-019-09089-x
  • Sprenger HS, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T (2019). Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2019 Jan;11(1). pii: e9288. doi: 10.15252/emmm.201809288                  
  • Rashid T, Nemazanyy I, Paolini C, Tatsuta T, Crespin P, de Villeneuve D, Brodesser S, Benit P, Rustin PA, Baraibar M, Agbulut O, Olivier A, Protasi F, Langer T, Chrast R, de Lonlay P, de Foucauld H, Blaauw B, Pende M (2019). Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. Embo J. 2019 Jan 3;38(1). pii: e99576. doi: 10.15252/embj.201899576. Epub 2018 Nov12               
  • Richter F, Dennerlein S, Nikolov M, Jans D, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P (2019). ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. J Cell Biol. 4;218(2):598-614. doi: 10.1083/jcb.201806093    
  • Hahn O, Drews LF, Nguyen A, Tatsuta T, Gkioni L, Hendrich O, Zhang Q, Langer T, Pletcher S, Wakelam MJO, Beyer A, Grönke S, Partridge L (2019). A nutritional memory effect counteracts the benefits of dietary restriction in old mice. Nat Metab. 1059–1073

Roman-Ulrich Müller

  • Ignarski M, Rill C, Kaiser RWJ, Kaldirim M, Neuhaus R, Esmaillie R, Li X, Klein C, Bohl K, Petersen M, Frese CK, Hoehne M, Atanassov I, Rinschen MM, Höpker K, Schermer B, Benzing T, Dietrich C, Fabretti F, Müller RU (2019). The RNA-protein interactome of differentiated kidney tubular epithelial cells. J Am Soc Nephrol. 2019 Apr;30(4):564-576. doi: 10.1681/ASN.2018090914. Epub 2019 Mar 13
  • Jain M, Kaiser RWJ, Bohl K, Hoehne M, Göbel H, Bartram MP, Habbig S, Müller RU, Fogo AB, Benzing T, Schermer B, Höpker K, Slaats GG (2019). Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis. Kidney Int. 2019 Apr;95(4):846-858. doi: 10.1016/j.kint.2018.10.034. Epub 2019 Feb 13
  • Rinschen MM, Müller RU (2019). A knowledge-guided kidney cell census-reconciling bulk omics with cellular heterogeneity? Kidney Int. 2019 Apr;95(4):733-735. doi: 10.1016/j.kint.2018.12.016
  • Braun F, Suarez V, Dinter J, Haneder S, Quaas A, Benzing T, Nierhoff D, Müller RU (2019). Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura. BMJ Open Gastroenterol. 2019 Feb 8;6(1):e000252. doi: 10.1136/bmjgast-2018-000252. eCollection 2019 
  • Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM (2019). The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3   
  • Kaiser RWJ, Ignarski M, Van Nostrand EL, Frese CK, Jain M, Cukoski S, Heinen H, Schaechter M, Seufert L, Bunte K, Frommolt P, Keller P, Helm M, Bohl K, Höhne M, Schermer B, Benzing T, Höpker K, Dieterich C, Yeo GW, Müller RU, Fabretti F (2019). A protein-RNA interaction atlas of the ribosome biogenesis factor AATF. Sci Rep. 2019 Jul 30;9(1):11071. doi: 10.1038/s41598-019-47552-3   
  • Müller RU, Schermer B (2019). Hippo signaling-a central player in cystic kidney disease? Pediatr Nephrol. 2019 Jul 11. doi: 10.1007/s00467-019-04299-3. [Epub ahead of print]   
  • Völker LA, Burkert K, Scholten N, Grundmann F, Kurschat C, Benzing T, Hampl J, Becker JU, Müller RU. (2019). A case report of recurrent membranoproliferative glomerulonephritis after kidney transplantation due to ventriculoatrial shunt infection, BMC Nephrol.2019 Aug 5;20(1):296. doi: 10.1186/s12882-019-1472-1   
  • Wöstmann F, Müller RU, Göbel H, Benzing T, Becker JU, Bartram MP (2019). Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome. BMC Nephrol. 2019 Aug 22;20(1):326. doi: 10.1186/s12882-019-1478-8   
  • Ignarski M, Islam R, Müller RU (2019). Long Non-Coding RNAs in Kidney Disease. Int J Mol Sci. 2019 Jul 3;20(13). pii: E3276. doi: 10.3390/ijms20133276

Carien Niessen

  • Persa OD, Niessen CM (2019). Epithelial polarity limits EMT. Nat Cell Biol. 2019 Mar;21(3):299-300. doi: 10.1038/s41556-019-0284-7

Peter Nürnberg

  • Prasetyanti PR, Hooff SR van, van Herwaarden T, de Vries N, Kalloe K, Rodermond H, van Leersum R, de Jong JH, Franitza M, Nurnberg P, Todaro M, Stassi G, Medema JP (2019). Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models. Int J Cancer. 2019 Jan 15;144(2):366-371. doi: 10.1002/ijc.31767. Epub 2018 Oct 22. 
  • Breast Cancer Res. 2019 Apr 29;21(1):55. doi: 10.1186/s13058-019-1137-9    
  • Asif M, Kaygusuz E, Brancati F, Nienberg C, Nickelsen A, Jose J, Hochscherf J, Niefind K, Noegel AA, Nurnberg P, Hussain MS (2019). De novo mutation of CSNK2B encoding beta subunit of casein kinase 2 causes Filippi syndrome. Eur J Hum Genet. 27, 1504-1505   
  • Bustos BI, Perez-Palma E, Buch S, Azocar L, Riveras E, Ugarte GD, Toliat M, Nurnberg P, Lieb W, Franke A, Hinz S, Burmeister G, von Schonfels W, Schafmayer C, Volzke H, Volker U, Homuth G, Lerch MM, Santos JL, Puschel K, Bambs C, Roa JC, Gutierrez RA, Hampe J, De Ferrari GV, Miquel JF (2019). Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry. Sci Rep. 2019 Jan 28;9(1):772. doi: 10.1038/s41598-018-35852-z   
  • Coppola A, Cellini E, Stamberger H, Saarentaus E, Cetica V, Lal D, Djemie T, Bartnik-Glaska M, Ceulemans B, Cross JH, Deconinck T, De Masi S, Dorn T, Guerrini R, Hoffman-Zacharska D, Kooy F, Lagae L, Lench N, Lemke JR, Lucenteforte E, Madia F, Mefford HC, Morrogh D, Nuernberg P, Palotie A, Schoonjans AS, Striano P, Szczepanik E, Tostevin A, Vermeesch JR, Van Esch H, Van Paesschen W, Waters JJ, Weckhuysen S, Zara F, Jonghe PD, Sisodiya SM, Marini C, Lehesjioki AE, Craiu D, Talvik T, Caglayan H, Serratosa J, Sterbova K, Moller RS, Hjalgrim H, Lerche H, Weber Y, Helbig I, von Spiczak S, Barba C, Bogaerts A, Boni A, Galizia EC, Chiari S, Clementella C, Di Gacomo G, Ferrari A, Guarducci S, Giglio S, Holmgren P, Leu C, Mari F, Melani F, Novara F, Pantaleo M, Peeters E, Pisano T, Rosati A, Sander J, Schoeler N, Stankiewicz P, Striano S, Suls A, Traverso M, Vandeweyer G, Van Dijck A, Zuffardi O, Consortium ER, Consortium E (2019). Diagnostic implications of genetic copy number variation in epilepsy plus. Epilepsia. 2019 Apr;60(4):689-706. doi: 10.1111/epi.14683. Epub 2019 Mar 13    
  • Cunha DL, Alakloby OM, Gruber R, Kakar N, Ahmad J. Alawbathani S, Plank R, Eckl K, Krabichler B, Altmuller J, Nurnberg P, Zschocke J, Borck G, Schmuth M, Alabdulkareem AS, Alnutaifi KA, Hennies HC (2019). Unknown mutations and genotype/phenotype correlations of autosomal recessive congenital ichthyosis in patients from Saudi Arabia and Pakistan. Mol Genet Genomic Med. 2019 Mar;7(3):e539. doi: 10.1002/mgg3.539. Epub 2019 Jan 1    
  • Dafsari HS, Kawalia A, Sprute R, Karakaya M, Malenica A, Herkenrath P, Nuernberg P, Motameny S, Thiele H, Cirak S (2019). Novel mutations in SLC6A5 with benign course in hyperekplexia. Cold Spring Harbor Molecular Case Stud. 2019 Dec; 5(6): a004465. doi: 10.1101/mcs.a004465    
  • Dafsari HS, Sprute R, Wunderlich G, Daimaguler HS, Karaca E, Contreras A, Becker K, Schulze-Rhonhof M, Kiening K, Karakulak T, Kloss M, Horn A, Pauls A, Nurnberg P, Altmuller J, Thiele H, Assmann B, Koy A,  Cirak S (2019). Correction to: Novel mutations in KMT2B offer pathophysiological insights on childhood-onset progressive dystonia. J Hum Genet. 64, 1051–1054 (2019). doi.org/10.1038/s10038-019-0644-y     
  • Dafsari HS, Sprute, R, Wunderlich G, Daimaguler HS, Karaca E, Contreras A, Becker K, Schulze-Rhonhof M, Kiening K, Karakulak T, Kloss M, Horn A, Pauls A, Nurnberg P, Altmuller J, Thiele H, Assmann B, Koy A, Cirak S (2019). Novel mutations in KMT2B offer pathophysiological insights into childhood-onset progressive dystonia. J Hum Genet. 2019 Aug;64(8):803-813. doi: 10.1038/s10038-019-0625-1. Epub 2019 Jun 5     
  • Diegmann S, Church J, Schnur R, Krusen M, Dreha-Kulaczewski S, Kuhn-Velten W, Wolf A, Huppke B, Millan F, Begtrup A, Almusafri F, Thiele H, Altmuller J, Nurnberg P, Muller M, Gartner J, Huppke P (2019). Inborn de novo mutations in NFE2L2 cause a multisystem disorder in children and adolescents: From gene identification to therapy development. Eur J Hum Genet. 27, 851-851     
  • Ding C, Scicluna BP, Stroo I. Yang J, Roelofs JJ, de Boer OJ, de Vos AF, Nurnberg P, Revenko AS, Crosby J, Van't Veer C, van der Poll T (2019). Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice. J Pathol. 2020 Jan; 250(1): 95–106. Published online 2019 Nov 25. doi: 10.1002/path.5354   
  • Du J, Sudarsanam M, Perez-Palma E, Ganna A, Francioli L, Iqbal S, Niestroj LM, Leu C, Weisburd B, Poterba T, Nurnberg P, Daly MJ, Palotie A, May P, Lal D (2019). Variant Score Ranker-a web application for intuitive missense variant prioritization. Bioinformatics. 2019 Nov 1;35(21):4478-4479. doi: 10.1093/bioinformatics/btz252   
  • Forstner AJ, Maaser A, Strohmaier J, Ludwig KU, Degenhardt F, Streit F, Thiele H, Nurnberg P, Herms S, Hoffmann P, Cichon S, Rietschel M, Nothen MM (2019). Exome Sequencing of Multiply Affected Bipolar Disorder Families and Follow-up Resequencing Implicate Rare Variants in Neuronal Genes Contributing to Disease Etiology. Eur Neuropsychopharm. 29, S836-S837   
  • Gopel W, Muller M, Rabe H, Borgmann J, Rausch TK, Faust K, Kribs A, Dotsch J, Ellinghaus D, Hartel C, Roll C, Szabo M, Nurnberg P, Franke A, Konig IR, Turner MA, Herting E (2019). Genetic background of high blood pressure is associated with reduced mortality in premature neonates. Arch Dis Child Fetal Neonatal Ed. Published Online First: 14 June 2019. doi: 10.1136/archdischild-2019-317131   
  • Grassmann F, Harsch S, Brandl C, Kiel C, Nurnberg P, Toliat MR, Fleckenstein M, Pfau M, Schmitz-Valckenberg S, Holz FG, Chew EY, Swaroop A, Ratnapriya R, Klein ML, Mulyukov Z, Zamiri P, Weber BHF (2019). Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration. JAMA Ophthalmol. 2019 May 23. doi: 10.1001/jamaophthalmol.2019.1318. [Epub ahead of print]   
  • Hauke J, Hahnen E, Schneider S. Reuss A, Richters L, Kommoss S, Heimbach A, Marme F, Schmidt S, Prieske K, Gevensleben H, Burges A, Borde J, De Gregorio N, Nurnberg P, El-Balat A, Thiele H, Hilpert F, Altmuller J, Meier W, Dietrich D, Kimmig R, Schoemig-Markiefka B, Kast K, Braicu E, Baumann K, Jackisch C, Park-Simon TW, Ernst C, Hanker L, Pfisterer J, Schnelzer A, du Bois A, Schmutzler RK, Harter P (2019). Deleterious somatic variants in 473 consecutive individuals with ovarian cancer: results of the observational AGO-TR1 study (NCT02222883). J Med Genet. 2019 Sep;56(9):574-580. doi: 10.1136/jmedgenet-2018-105930. Epub 2019 Apr 12   
  • Huppke P, Wegener E, Gilley J, Angeletti C, Kurth I, Drenth JPH, Stadelmann C, Barrantes-Freer A, Bruck W, Thiele H, Nurnberg P, Gartner J, Orsomando G, Coleman MP (2019). Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia. Exp Neurol. 2019 Oct;320:112958. doi: 10.1016/j.expneurol.2019.112958. Epub 2019 May 24   
  • Hussain MS, Baig SM, Moawia A, Shaheen R, Ewida N, Al-Owain M, Rasool S, Budde B, Hahn A, Noegel AA, Alkuraya FS, Nurnberg P (2019). Mutations of KIF14, encoding a kinesin-3 family member of microtubule motors, cause primary microcephaly. Eur J Hum Genet. 27, 301-302   
  • Jurkute N, Leu C, Pogoda HM, Arno G, Robson AG, Nurnberg G, Altmuller J, Thiele H, Motameny S, Toliat MR, Powell K, Hohne W, Michaelides M, Webster AR, Moore AT, Hammerschmidt M, Nurnberg P, Yu-Wai-Man P, Votruba M (2019). SSBP1 mutations in dominant optic atrophy with variable retinal degeneration. Ann Neurol. 2019 Sep;86(3):368-383. doi: 10.1002/ana.25550. Epub 2019 Jul 31   
  • Karakaya M, Storbeck M, Strathmann E, Delle Vedove A, Hoelker I, Altmueller J, Motameny S, Alawbathani S, Thiele H, Polat I, Wunderlich G, Ardicli D, Topaloglu H, Kirschner J, Schrank B, Maroofian R, Magnusson O, Yis U, Nuernberg P, Heller R, Wirth B (2019). Identification and characterization of disease-causing genes in non-5q-SMA by next-generation sequencing technology: Lessons learned from NeurOmics study. Eur J Hum Genet.  27, 1483-1484    
  • Karsak M, Glebov K, Scheffold M, Bajaj T, Kawalia A. Karaca I, Rading S, Kornhuber J, Peters O, Diez-Fairen M, Frolich L, Hull M, Wiltfang J, Scherer M, Riedel-Heller S, Schneider A, Heneka MT, Fliessbach K, Sharaf A, Thiele H, Lennarz M, Jessen F, Maier W, Kubisch C, Ignatova Z, Nurnberg P, Pastor P, Walter J, Ramirez A (2019). A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2. Hum Mutat. 2020 Jan;41(1):169-181. doi: 10.1002/humu.23904. Epub 2019 Sep 15    
  • Khan HN, Perlee D, Schoenmaker L, Van Der Meer AJ, Franitza M, Toliat MR, Nuernberg P, Zwinderman AH, van Der Poll T, Scicluna BP (2019). Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia. J Leukoc Biol. 2019 Nov;106(5):1153-1160. doi: 10.1002/JLB.4A0219-050R. Epub 2019 Jul 7    
  • Khayyat AIA, Baig SM, Abdullah U, Haq EU, Ali Z, Malik NA, Tariq M, Budde B, Noegel AA, Nurnberg P, Hussain MS (2019). Mutation in C1orf131, encoding a novel nucleolar protein, causes intellectual disability in a large Pakistani family. Eur J Hum Genet. 27, 1392-1393   
  • Kinfe TM, Asif M, Chakravarthy KV, Deer TR, Kramer JM, Yearwood TL, Hurlemann R, Hussain MS, Motameny S, Wagle P, Nurnberg P, Gravius S, Randau T, Gravius N, Chaudhry SR, Muhammad S (2019). Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling. J Transl Med. 2019 Jun 19;17(1):205. doi: 10.1186/s12967-019-1952-x   
  • Lerche H, Berkovic SF, Lowenstein DH, May P, Wolking S, Musa MK, Lal D, Heyne HO, Bobbili DR, Perez-Palma E, Schubert J, Becker F, Thiele H, Altmuller J, Jabbari K, Ruppert AK, Jurkowski W, Striano P, Caglayan H, Yalcin D, Dizdarer G, Aslan K, Yapici Z, Kuscu D, Siren A, Moller RS, Hjalgrim H, Nikanorova M, Muhle H, Helbig I, Kunz W, Weber Y, Weckhuysen S, Jonghe P, Sisodiya S, Nabbout R, Balling R, Sander T, Koeleman BPC, Palotie A, Lehesjoki AE, Nothnagel M, Nurnberg P, Zara F, Krause R, Lerche H, Leu C, Peter S, Weber YG, Avbersek A, Heggeli K, Gambardella A, Langley SR, Krenn M, Klein KM, McCormack M, Borghei M, Willis J, Berghuis B, Jorgensen A, Auce P, Francis B, Srivastava P, Sonsma ACM, Sander JW, Zimprich F, Depondt C, Johnson MM, Marson AG, Sills GJ, Kunz WS, Cavalleri GL, Delanty N, Sisodiya SM, Heinzen EL, Petrovski S, Allen AS, Bellows ST, Berkovic SF, Bridgers J, Burgess R, Cavalleri G, Chung SK, Cossette P, Dlugos D, Epstein MP, Freyer C, Goldstein DB, Hildebrand MS, Johnson MR, Kuzniecky R, Lowenstein DH, Mayeux R, Mebane C, Mefford HC, O'Brien TJ, Ottman R, Petrou S, Pickrell WO, Poduri A, Radtke RA, Rees MI, Regan BM, Ren Z, Scheffer IE, Thomas RH, Wang Q, Consortium EC, Consortium E, Phenome EKCE (2019). Intestinal-Cell Kinase and Juvenile Myoclonic Epilepsy. N Engl J Med. 2019 Apr 18;380(16):e24. doi: 10.1056/NEJMc1805100    
  • Liao DS, Grossi FV, El Mehdi D, Gerber MR, Brown DM, Heier JS, Wykoff CC, Singerman LJ, Abraham P, Grassmann F, Nuernberg P, Weber BHF, Deschatelets P, Kim RY, Chung CY, Ribeiro RM, Hamdani M, Rosenfeld PJ, Boyer DS, Slakter JS, Francois CG (2019). Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial. Ophthalmology. 2020 Feb;127(2):186-195. doi: 10.1016/j.ophtha.2019.07.011. Epub 2019 Jul 16   
  • Lima Cunha D, Alakloby OM, Gruber R, Kakar N, Ahmad J, Alawbathani S, Plank R, Eckl K, Krabichler B, Altmuller J, Nurnberg P, Zschocke J, Borck G, Schmuth M, Alabdulkareem AS, Abdulaziz Alnutaifi K, Hennies HC (2019). Unknown mutations and genotype/phenotype correlations of autosomal recessive congenital ichthyosis in patients from Saudi Arabia and Pakistan. Mol Genet Genomic Med. 2019 Mar;7(3):e539. doi: 10.1002/mgg3.539. Epub 2019 Jan 1    
  • Maaser A, Strohmaier J, Ludwig KU, Henschel L, Streit F, Degenhardt F, Sivalingam S, Schenk LM, Koller AC, Fischer SB, Thiele H, Nurnberg P, Parra JG, Diaz GO, Auburger G, Albus M, Borrmann-Hassenbach M, Gonzalez MJ, Flores SG, Fabeiro FJC, Noriega FD, Perez FP, Gonzalez JH, Rivas F, Mayoral F, Herms S, Hoffmann P, Cichon S, Rietschel M, Nothen MM, Forstner AJ (2019). Exome sequencing of multiplex bipolar disorder families and follow-up resequencing implicate rare variants in neuronal genes contributing to disease etiology. Eur J Hum Genet. 27, 261-262    
  • Mehrjoo Z, Fattahi Z, Beheshtian M, Mohseni M, Poustchi H, Ardalani F, Jalalvand K, Arzhangi S, Mohammadi Z, Khoshbakht S, Najafi F, Nikuei P, Haddadi M, Zohrehvand E, Oladnabi M, Mohammadzadeh A, Jafari MH, Akhtarkhavari T, Gooshki ES, Haghdoost A, Najafipour R, Niestroj LM, Helwing B, Gossmann Y, Toliat MR, Malekzadeh R, Nurnberg P, Kahrizi K, Najmabadi H, Nothnagel M (2019). Distinct genetic variation and heterogeneity of the Iranian population. PLoS Genet. 2019 Sep 24;15(9):e1008385. doi: 10.1371/journal.pgen.1008385. eCollection 2019 Sep    
  • Moosa S, Yamamoto GL, Garbes L, Keupp K, Beleza-Meireles A, Moreno CA, Valadares ER, de Sousa SB, Maia S, Saraiva J, Honjo RS, Kim CA, Cabral de Menezes H, Lausch E, Lorini PV, Lamounier A, Jr., Carniero TCB, Giunta C, Rohrbach M, Janner M, Semler O, Beleggia F, Li Y, Yigit G, Reintjes N, Altmuller J, Nurnberg P, Cavalcanti DP, Zabel B, Warman ML, Bertola DR, Wollnik B, Netzer C (2019). Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta. Am J Hum Genet. 2019 Oct 3;105(4):836-843. doi: 10.1016/j.ajhg.2019.08.008. Epub 2019 Sep 26    
  • Niestroj LM, May P, Artomov M, Kobow K, Coras R, Perez-Palma E, Altmuller J, Thiele H, Nurnberg P, Leu C, Palotie A, Daly MJ, Klein KM, Beschorner R, Weber YG, Blumcke I, Lal D (2019). Assessment of genetic variant burden in epilepsy-associated brain lesions. Eur J Hum Genet. EJHG 27, 1738-1744
  • Ozieblo D, Sarosiak A, Leja ML, Budde BS, Tacikowska G, Di Donato N, Bolz HJ, Nurnberg P, Skarzynski H, Oldak M (2019). First confirmatory study on PTPRQ as an autosomal dominant non-syndromic hearing loss gene. J Transl Med. 2019 Oct 26;17(1):351. doi: 10.1186/s12967-019-2099-5    
  • Pauli S, Altmuller J, Schroder S, Ohlenbusch A, Dreha-Kulaczewski S, Bergmann C, Nurnberg P, Thiele H, Li Y, Wollnik B, Brockmann K (2019). Homozygosity for the c.428delG variant in KIAA0586 in a healthy individual: implications for molecular testing in patients with Joubert syndrome. J Med Genet. 2019 Apr;56(4):261-264. doi: 10.1136/jmedgenet-2018-105470. Epub 2018 Aug 17    
  • Perez-Palma E, Bustos BI, Lal D, Buch S, Azocar L, Toliat MR, Lieb W, Franke A, Hinz S, Burmeister G, von Shonfels W, Schafmayer C, Ahnert P, Volzke H, Volker U, Homuth G, Lerch MM, Puschel K, Gutierrez RA, Hampe J, Nurnberg P, Miquel JF, De Ferrari GV (2019). Copy number variants in lipid metabolism genes are associated with gallstones disease in men. Eur J Hum Genet. EJHG    
  • Perez-Palma E, Gramm M, Nurnberg P, May P, Lal D (2019). Simple ClinVar: an interactive web server to explore and retrieve gene and disease variants aggregated in ClinVar database. Nucleic Acids Res. 47, W99-W105    
  • Pergande M, Motameny S, Ozdemir O, Kreutzer M, Wang H, Daimaguler HS, Becker K, Karakaya M, Ehrhardt H, Elcioglu N, Ostojic S, Chao CM, Kawalia A, Duman O, Koy A, Hahn A, Reimann J, Schoner K, Schanzer A, Westhoff JH, Schwaibold EMC, Cossee M, Imbert-Bouteille M, von Pein H, Haliloglu G, Topaloglu H, Altmuller J, Nurnberg P, Thiele H, Heller R, Cirak S (2019). The genomic and clinical landscape of fetal akinesia. Genet Med. 2019 Nov 4. doi: 10.1038/s41436-019-0680-1. [Epub ahead of print]    
  • Perlee D, de Vos AF, Scicluna BP, Mancheno P, de la Rosa O, Dalemans W, Nurnberg P, Lombardo E, van der Poll T (2019). Human Adipose-Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae. Stem Cells Transl Med. 2019 Aug;8(8):785-796. doi: 10.1002/sctm.18-0260. Epub 2019 Apr 29     
  • Prasetyanti PR, van Hooff AR, van Herwaarden T, de Vries N, Kalloe K, Rodermond H, van Leersum R, de Jong JH, Franitza M, Nurnberg P, Todaro M, Stassi G, Medema JP (2019). Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models. Int J Cancer. 2019 Jan 15;144(2):366-371. doi: 10.1002/ijc.31767. Epub 2018 Oct 22   
  • Preising MN, Gorg B, Friedburg C, Qvartskhava N, Budde BS, Bonus M, Toliat MR, Pfleger C, Altmuller J, Herebian D, Beyer M, Zollner HJ, Wittsack HJ, Schaper J, Klee D, Zechner U, Nurnberg P, Schipper J, Schnitzler A, Gohlke H, Lorenz B, Haussinger D, Bolz HJ (2019). Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration. FASEB J. 2019 Oct;33(10):11507-11527. doi: 10.1096/fj.201900914RR. Epub 2019 Jul 25    
  • Romano M, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC (2019). Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex. Eur J Hum Genet. 27, 1282-1283    
  • Vidal EA, Moyano TC, Bustos BI, Perez-Palma E, Moraga C, Riveras E, Montecinos A, Azocar L, Soto DC, Vidal M, Di Genova A, Puschel K, Nurnberg P, Buch S, Hampe J, Allende ML, Cambiazo V, Gonzalez M, Hodar C, Montecino M, Munoz-Espinoza C, Orellana A, Reyes-Jara A, Travisany D, Vizoso P, Moraga M, Eyheramendy S, Maass A, De Ferrari GV, Miquel JF, Gutierrez RA (2019). Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans. Sci Rep. 2019 Feb 14;9(1):2132. doi: 10.1038/s41598-019-39391-z   
  • Vogelmann S, Kleinheinz K, Altmuller J, Thiele H, Nurnberg P, Schlesner M, Klapper W, Bruggemann M, Siebert R, Wagener R, Oschlies I (2019). Genetic Characterization of two Variants of the primary cutaneous Follicle Center Lymphoma. J Dtsch Dermatol. Ges 17, 1-2   
  • Wagener R, Seufert J, Raimondi F, Bens S, Kleinheinz K, Nagel I, Altmuller J, Thiele H, Hubschmann D, Kohler CW, Nurnberg P, Au-Yeung R, Burkhardt B, Horn H, Leoncini L, Jaffe ES, Ott G, Rymkiewicz G, Schlesner M, Russell RB, Klapper W, Siebert R (2019). The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Blood. 2019 Feb 28;133(9):962-966. doi: 10.1182/blood-2018-07-864025. Epub 2018 Dec 19   
  • Weber-Lassalle N, Borde J, Weber-Lassalle K, Horvath J, Niederacher D, Arnold N, Kaulfuss S, Ernst C, Paul VG, Honisch E, Klaschik K, Volk AE, Kubisch C, Rapp S, Lichey N, Altmuller J, Lepkes L, Pohl-Rescigno E, Thiele H, Nurnberg P, Larsen M, Richters L, Rhiem K, Wappenschmidt B, Engel C, Meindl A, Schmutzler RK, Hahnen E, Hauke J (2019). Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer. Breast Cancer Res. 2019 Apr 29;21(1):55. doi: 10.1186/s13058-019-1137-9

Linda Partridge

  • Weigelt CM, Hahn O, Arlt K, Gruhn M, Jahn AJ, Esser J, Werner JA, Klein C, Buschges A, Gronke S, Partridge L (2019). Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster. Life Sci Alliance. 2019 Jan 22;2(1). pii: e201800149. doi: 10.26508/lsa.201800149. Print 2019 Feb
  • Fuentealba M, Dönertaş HM, Williams R, Labbadia J, Thornton JM, Partridge L (2019). Using the drug-protein interactome to identify anti-ageing compounds for humans. PLoS Comput Biol. 2019 Jan 9;15(1):e1006639. doi: 10.1371/journal.pcbi.1006639. eCollection 2019 Jan
  • Moens TG, Niccoli T, Wilson KM, Atilano ML, Birsa N, Gittings LM, Holbling BV, Dyson MC, Thoeng A, Neeves J, Glaria I, Yu L, Bussmann J, Storkebaum E, Pardo M, Choudhary JS, Fratt, P, Partridge L, Isaacs AM (2019). C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathol. 2019 Mar;137(3):487-500. doi: 10.1007/s00401-018-1946-4. Epub 2019 Jan 2  
  • Juricic P, Grönke S, Partridge L (2019). Branched-chain amino acids have equivalent effects to other essential amino acids on lifespan and ageing-related traits in Drosophila. J Gerontol A Biol Sci Med Sci. 2019 Mar 20. pii: glz080. doi: 10.1093/gerona/glz080    
  • Augustin H, Zylbertal A, Partridge L (2019). A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster. eNeuro. 6, e0423-18.2019    
  • Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, Partridge L, Ichida JK, Isaacs AM, Petrucelli L, Gitler AD (2019). RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nat Neurosci. 2019 Sep;22(9):1383-1388. doi: 10.1038/s41593-019-0455-7. Epub 2019 Jul 29   
  • Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Grönke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L (2019). A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20817-20819. doi: 10.1073/pnas.1913212116. Epub 2019 Sep 30   
  • Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ  (2019). Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nat Metab. 2019 May;1(5):532-545. doi: 10.1038/s42255-019-0059-2. Epub 2019 Apr 29             
  • Hahn O, Drews LF, Nguyen A, Tatsuta T, Gkioni L, Hendrich O, Zhang Q, Langer T, Pletcher S, Wakelam MJO, Beyer A, Grönke S, Partridge L (2019). A nutritional memory effect counteracts the benefits of dietary restriction in old mice. Nat Metab. 1059–1073

Manolis Pasparakis  

  • Krishna-Subramanian S, Singer S, Armaka M, Banales JM, Holzer K, Schirmacher P, Walczak H, Kollias G, Pasparakis M, Kondylis V (2019). RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death Differ. 2019 Apr 15. doi: 10.1038/s41418-019-0330-9. [Epub ahead of print]
  • Kondylis V, Pasparakis M (2019). RIP Kinases in Liver Cell Death, Inflammation and Cancer. Trends Mol Med. 2019 Jan;25(1):47-63. doi: 10.1016/j.molmed.2018.10.007. Epub 2018 Nov 16      
  • Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke H, Fava LL, Haschka MD, Glatter T, Nesvizhskii A, Schmidt A, Harris PA, Bertin J, Gough PJ, Villunger A, Silke J, Pasparakis M, Bianchi K, Meier P (2019). RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell. 2019 Feb 7;73(3):413-428.e7. doi: 10.1016/j.molcel.2018.11.010. Epub 2018 Dec 28               
  • Koliaraki V, Chalkidi N, Henriques A, Tzaferis C, Polykratis A, Waisman A, Muller W, Hackam DJ, Pasparakis M, Kollias G (2019). Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis. Cell Rep. 2019 Jan 15;26(3):536-545.e4. doi: 10.1016/j.celrep.2018.12.072    
  • Gräb J, Suárez I, van Gumpel E, Winter S, Schreiber F, Esser A, Hölscher C, Fritsch M, Herb M, Schramm M, Wachsmuth L, Pallasch C, Pasparakis M, Kashkar H, Rybniker J (2019). Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition. Nat Commun. 2019 Feb 8;10(1):688. doi: 10.1038/s41467-019-08405-9
  • Eftychi C, Schwarzer R, Vlantis K, Wachsmuth L, Basic M, Wagle P, Neurath MF, Becker C, Bleich A, Pasparakis M. (2019)Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment. Immunity. 2019 Aug 20;51(2):367-380.e4. doi: 10.1016/j.immuni.2019.06.008. Epub 2019 Jul 23
  • Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M. (2019). A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain. Nat Cell Biol. 2019 Jun;21(6):731-742. doi: 10.1038/s41556-019-0324-3.
  • Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M (2019). RIPK1 mediates TNF-induced intestinal crypt apoptosis during chronic NF-κB activation. Cell Mol Gastroenterol Hepatol. 2019 Oct 10. pii: S2352-345X(19)30138-9. doi: 10.1016/j.jcmgh.2019.10.002. [Epub ahead of print]
  • D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, Croker BA (2019). The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Sci Signal. 2018 Sep 4;11(546). pii: eaao1716. doi: 10.1126/scisignal.aao1716.
  • Priem D, Devos M, Druwé S, Martens A, Slowicka K, Ting AT, Pasparakis M, Declerq W, Vandenabeele P, van Loo G, Bertrand MJM (2019). A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms. Cell Death Dis. 2019 Sep 18;10(10):692. doi: 10.1038/s41419-019-1937-y.
  • Lalaoui N, Boyden SE, Oda H, Wood GM, Stone DL, Chau D, Liu L, Stoffels M, Kratina T, Lawlor KE, Zaal KJM, Hoffmann PM, Etemadi N, Shield-Artin K, Biben C, Tsai WL, Blake MD, Kuehn HS, Yang D, Anderton H, Silke N, Wachsmuth L, Zheng L, Moura NS, Beck DB, Gutierrez-Cruz G, Ombrello AK, Pinto-Patarroyo GP, Kueh AJ, Herold MJ, Hall C, Wang H, Chae JJ, Dmitrieva NI, McKenzie M, Light A, Barham BK, Jones A, Romeo TM, Zhou Q, Aksentijevich I, Mullikin JC, Gross AJ, Shum AK, Hawkins ED, Masters SL, Lenardo MJ, Boehm M, Rosenzweig SD, Pasparakis M, Voss AK, Gadina M, Kastner DL, Silke J (2019). Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature. 2019 Dec 11. doi: 10.1038/s41586-019-1828-5. [Epub ahead of print]   
  • MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Krüger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Brüning JC, Zamboni N, Langer T (2019). Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature. 2019 Nov;575(7782):361-365. doi: 10.1038/s41586-019-1738-6. Epub 2019 Nov 6    
  • Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F, Vogel W, Klümper N, Nolte H, Wittersheim M, Tharun L, Castiglione R, Krüger M, Schauss A, Perner S, Pasparakis M, Büttner R, Persigehl T, Hucho T, Herter-Sprie GS, Schumacher B, Reinhardt HC (2019). The Cdkn1a<sup>SUPER</sup> Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Rep. 2018 Oct 23;25(4):1027-1039.e6. doi: 10.1016/j.celrep.2018.09.079    
  • Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H (2019). Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature. 2019 Nov;575(7784):683-687. doi: 10.1038/s41586-019-1770-6. Epub 2019 Nov 20      

Maria de las Nieves Peltzer  

  • Peltzer N, Walczak H (2019). Cell Death and Inflammation - A Vital but Dangerous Liaison. Trends Immunol. 2019 May;40(5):387-402. doi: 10.1016/j.it.2019.03.006. Epub 2019 Apr 16

Lena Pernas   

  • Pernas L (2019). mSphere of Influence: Finding a Direction-How Do Mitochondria Know Where To Go? mSphere. 2019 Jul 3;4(4). pii: e00321-19. doi: 10.1128/mSphere.00321-19

Simon Pöpsel 

  • Kasinath V, Poepsel S, Nogales, E (2019). Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding. Biochemistry. 2019 Feb 5;58(5):346-354. doi: 10.1021/acs.biochem.8b01064. Epub 2018 Dec 3  

Alvaro Rada-Iglesias

  • Zanella M, Vitriolo A, Andirko A, Martins PT, Sturm S, O'Rourke T, Laugsch M, Malerba N, Skaros A, Trattaro S, Germain PL, Mihailovic M, Merla G, Rada-Iglesias A, Boeckx C, Testa G (2019). Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication. Sci Adv. 2019 Dec 4;5(12):eaaw7908. doi: 10.1126/sciadv.aaw7908. eCollection 2019 Dec
  • Pachano T, Crispatzu G, Rada-Iglesias A (2019). Polycomb proteins as organizers of 3D genome architecture in embryonic stem cells. Brief Funct Genomics. 2019 Nov 19;18(6):358-366. doi: 10.1093/bfgp/elz022  
  • Bleckwehl T, Rada-Iglesias A (2019). Transcriptional and epigenetic control of germline competence and specification. Curr Opin Cell Biol. 2019 Dec;61:1-8. doi: 10.1016/j.ceb.2019.05.006. Epub 2019 Jun 21  Matheus F, Rusha E, Rehimi R, Molitor L, Pertek A, Modic M, 
  • Feederle R, Flatley A, Kremmer E, Geerlof A, Rishko V, Rada-Iglesias A, Drukker M (2019). Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development. Stem Cell Reports. 2019 May 14;12(5):861-868. doi: 10.1016/j.stemcr.2019.03.006. Epub 2019 Apr 18  
  • Laugsch M, Bartusel M, Rehimi R, Alirzayeva H, Karaolidou A, Crispatzu G, Zentis P, Nikolic M, Bleckwehl T, Kolovos P, van Ijcken WFJ, Šarić T, Köhler K, Frommolt P, Lachlan K, Baptista J, Rada-Iglesias, A (2019). Modelling the pathological long-range regulatory effects of human structural variation with patient-specific hiPSCs. Cell Stem Cell. 2019 May 2;24(5):736-752.e12. doi: 10.1016/j.stem.2019.03.004. Epub 2019 Apr 11  
  • Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L (2019). yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell Stem Cell. 2018 Nov 21. pii: S1934-5909(18)30541-1. doi: 10.1016/j.stem.2018.11.005. PMID: 30554961

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Hans Christian Reinhardt

  • Jachimowicz RD, Bhavana VB, Beleggia F, Isensee J, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y(2019). UBQLN4 regulates double-strand break repair by repressing homologous recombination and is overexpressed in aggressive tumors, Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3     
  • Castiglione R, Alidousty C, Holz B, Wagener S, Baar T, Heydt C, Binot E, Zupp S, Kron A, Wolf J, Merkelbach-Bruse S, Reinhardt HC, Büttner R, Schultheis AM (2019). Comparison of the genomic background of MET-altered carcinomas of the lung: biological differences and analogies. Mod Pathol. 2019 May;32(5):627-638. doi: 10.1038/s41379-018-0182-8. Epub 2018 Nov 20
  • Grimm C, Fischer A, Farrelly AM, Kalachand R, Castiglione R, Wasserburger E, Hussong M, Schultheis A, Altmüller J, Thiele H, Reinhardt HC, Hauschulz K, Hennessy BT, Herwig R, Lienhard M, Büttner R, Schweiger MR (2019). Combined targeted re-sequencing of cytosine DNA methylations and mutations for the determination of PARP1 inhibitor sensitivity. J Mol Diagn. 2019 Mar;21(2):198-213. doi: 10.1016/j.jmoldx.2018.10.007. Epub 2018 Dec 19

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Jan Riemer  

  • Anton V, Buntenbroich I, Schuster R, Babatz F, Simões T, Altin S, Calabrese G, Riemer J, Schauss A, Escobar-Henriques M (2019). Plasticity in salt-bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition. Life Sci Alliance. 2019 Nov 18;2(6). pii: e201900491. doi: 10.26508/lsa.201900491. Print 2019 Dec  
  • Calabrese G, Peker E, Amponsah PS, Hoehne MN, Riemer T, Mai M, Bienert GP, Deponte M, Morgan B, Riemer J (2019). Hyperoxidation of mitochondrial peroxiredoxin limits H2 O2 -induced cell death in yeast. EMBO J. 2019 Sep 16;38(18):e101552. doi: 10.15252/embj.2019101552. Epub 2019 Aug 7  
  • Habich M, Salscheider S, Murschall L, Hoehne M, Fischer M, Schorn F, Petrungaro C, Ali M, Erdogan A, Abou-Eid S, Kashkar H, Dengjel J, Riemer J (2019). Vectorial import via a metastable disulfide-linked complex allows for a quality control step and efficient import by the mitochondrial disulfide relay. Cell Rep. 2019 Jan 15;26(3):759-774.e5. doi: 10.1016/j.celrep.2018.12.092  
  • MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Krüger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Brüning JC, Zamboni N, Langer T (2019). Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature. 2019 Nov;575(7782):361-365. doi: 10.1038/s41586-019-1738-6. Epub 2019 Nov 6

Elena Rugarli

  • Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G. The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα. Nat Commun. 2019 Apr 5;10(1):1566. doi: 10.1038/s41467-019-09598-9. PMID: 30952952
  • Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI (2019). Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. 2019 Aug;67(8):1526-1541. doi: 10.1002/glia.23626. Epub 2019 Apr 16
  • Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola A, Wai T, Barth E, Rugarli EI, Bergami M, and Langer T. (2019) Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 11, pii: e9288. doi 10.15252/emmm. 201809288

Björn Schumacher

  • Jachimowicz RD, Bhavana VB, Beleggia F, Isensee J, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y(2019). UBQLN4 regulates double-strand break repair by repressing homologous recombination and is overexpressed in aggressive tumors, Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3  
  • Doll MA, Soltanmohammadi N, Schumacher B (2019). ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstreamof the Core Apoptotic Machinery in Caenorhabditis elegans. Genetics. 2019 Jul 11. pii: genetics.302458.2019. doi: 10.1534/genetics.119.302458.
  • Ou HL, Kim CS, Uszkoreit S, Wickström SA, Schumacher B (2019). Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. Dev Cell. 2019 Jul 22;50(2):167-183.e8. doi: 10.1016/j.devcel.2019.06.012 
  • Williams AB, Heider F, Messling JE, Riekher M, Bloch W, Schumacher B (2019).Restorationof Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans. Genetics. 2019 Aug;212(4):1259-1278. doi: 10.1534/genetics.119.302422. Epub 2019 Jun 27 
  • Bayersdorf R, Schumacher B (2019).Recent advances in understanding the mechanisms determining longevity. F1000Res. 2019 Aug 9;8. pii: F1000 Faculty Rev-1403. doi: 10.12688/f1000research.19610.1. eCollection 2019 
  • Rive C, Reina G, Wagle P, Treossi E, Palermo V, Bianco A, Gemma-Delogu L, Rieckher M, Schumacher B(2019).Improved Biocompatibility of Amino-functionalized Graphene Oxide in Caenorhabditis elegans. Small. 2019 Nov;15(45):e1902699. doi: 10.1002/smll.201902699. Epub 2019 Oct 1  
  • Schumacher B, Vijg J (2019). Age is in the nucleus. Nat Metab. 2019. doi: 10.1038/s42255-019-0125-9. Epub 2019 Oct 7

Eline Slagboom

  • Berg N van den, Rodríguez-Girondo M, van Dijk IK, Mourits RJ, Mandemakers K, Janssens AAPO, Beekman M, Smith KR, Slagboom PE (2019). Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait. Nat Commun. 2019 Jan 7;10(1):35. doi: 10.1038/s41467-018-07925-0
  • De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM (2019). L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9
  • Meessen JMTA, Fiocco M, Leichtenberg CS, Vliet Vlieland TPM, Slagboom PE, Nelissen RGHH (2019). Frailty Questionnaire Is Not a Strong Prognostic Factor for Functional Outcomes in Hip or Knee Arthroplasty Patients. Geriatr Orthop Surg Rehabil. 2019 Feb 4;10:2151459318808164. doi: 10.1177/2151459318808164 
  • Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, SlagboomPE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (2019). Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006851. doi: 10.1212/WNL.0000000000006851. [Epub ahead of print]

Philipp Steven  

  • Osae EA, Steven P, Redfern R, Hanlon S, Smith CW, Rumbaut RE, Burns AR (2019). Dyslipidemia and Meibomian Gland Dysfunction: Utility of Lipidomics and Experimental Prospects with a Diet-Induced Obesity Mouse Model. Int J Mol Sci. 2019 Jul 17;20(14). pii: E3505. doi: 10.3390/ijms20143505. PubMed PMID: 31319467;PubMed Central PMCID: PMC6678820 
  • Eberwein P, Krösser S, Steven P (2019). Semifluorinated Alkane Eye Drops in Chronic Ocular Graft-versus-Host Disease: A Prospective, Multicenter, Noninterventional Study. Ophthalmic Res. 2020;63(1):50-58. doi: 10.1159/000499158. Epub 2019 May 22. PubMed PMID: 31117087
  • Faust C, Dietrich-Ntoukas T, Steven P (2019). [Second Survey on Patient-centred Care of Ocular Graft-versus-Host Disease in Germany]. Klin Monbl Augenheilkd. 2019 May 10. doi: 10.1055/a-0854-3984. [Epub ahead of print] German. PubMed PMID: 31075805
  • Wirta DL, Torkildsen GL, Moreira HR, Lonsdale JD, Ciolino JB, Jentsch G, Beckert M, Ousler GW, Steven P, Krösser S (2019). A Clinical Phase II Study to Assess Efficacy, Safety, and Tolerability of Waterfree Cyclosporine Formulation for Treatment of Dry Eye Disease. Ophthalmology. 2019 Jun;126(6):792-800. doi: 10.1016/j.ophtha.2019.01.024. Epub 2019 Jan 28. PubMed PMID: 30703441

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Peter Tessarz

  • Pouikli A, Parekh S, Maleszewska M, Baghdadi M, Tripodi I, Nikopoulou C, Folz-Donahue K, Hinze Y, Mesaros A, Giavalisco P, Dowell R, Partridge L, Tessarz P (2019). Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of ageing mesenchymal stem cells.bioRxiv  
  • Nikopoulou C,Parekh S, Tessarz P (2019). Ageing and sources of transcriptional heterogeneity. Biol Chem. 400(7); 867-878   
  • Mylonas C, Tessarz P (2019). NET-prism enables RNA polymerase-dedicated transcriptional interrogation at nucleotide resolution. RNA Biol. 2019 Sep;16(9):1156-1165. doi: 10.1080/15476286.2019.1621625. Epub 2019 Jun 3

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Marc Tittgemeyer

  • Baldermann JC, Melzer C, Zapf A, Kohl S, Timmermann L, Tittgemeyer M, Huys D, Visser-Vandewalle V, Kühn AA, Horn A and Kuhn J (2019). Connectivity profile predictive of effective deep brain stimulation in obsessive compulsive disorder. Biol Psychiatry. 2019 May 1;85(9):735-743. doi: 10.1016/j.biopsych.2018.12.019. Epub 2019 Jan 9
  • Glaab E, Trezzi JP, Greuel A, Jaeger C, Hodak Z, Drzezga A, Timmermann L, Tittgemeyer M, Diederich NJ, Eggers C (2019). Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson’s disease. Neurobiol Dis. 2019 Apr;124:555-562. doi: 10.1016/j.nbd.2019.01.003. Epub 2019 Jan 
  • Hammes J, Theis H, Giehl K, Hoenig MC, Greuel A, Tittgemeyer M, Timmermann L, Fink GR, Drzezga A, Eggers C, van Eimeren T (2019). Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control. Brain. 2019 Mar 1;142(3):733-743. doi: 10.1093/brain/awz007
  • Lippert RN, Cremer AL, Edwin Thanarajah S, Korn C, Jajans-Price T, Burgeno LM, Tittgemeyer M, Bruening JC, Walton ME, Backes H (2019). Time-dependent assessment of stimulus-evoked regional dopamine release. Nat Commun. 2019 Jan 18;10(1):336. doi: 10.1038/s41467-018-08143-4     
  • Edwin Thanarajah S, Backes H, DiFeliceantonio A, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Bruening JC, Tittgemeyer M (2019) Food intake recruits orosensory and post-ingestive dopaminergic circuits to affect eating desire in humans. Cell Metabolism 2019 Mar 5;29(3):695-706.e4. doi: 10.1016/j.cmet.2018.12.006. Epub 2018 Dec 27   
  • Pelzer EA, Dillenburger B, Grundmann S, Illialev V, Aschenberg S, Melzer C, Hess M, Fink GR, Eggers C, Tittgemeyer M, Timmermann L (2019). Hypomania and saccadic changes in Parkinson’s disease: influence of D2 and D3 dopaminergic signalling. NPJ Parkinsons Dis. 2020 Jan 17;6:5. doi: 10.1038/s41531-019-0107-3. eCollection 2020    
  • Sevgi M, Diacunescu AO, Henco L, Tittgemeyer M, Schilbach L (2019). Social Bayes: Using Bayesian modeling to study autistic trait-related differences in social Cognition. Biol Psychiatry. 2016 Jul 15;80(2):112-119. doi: 10.1016/j.biopsych.2015.11.025. Epub 2015 Dec 9  
  • Mosley P, Paliwal S, Robinson K, Coyne T, Silburn P, Stephan KE, Tittgemeyer M, Breakspeare M (2019). The Structural Connectivity of Discrete Networks Underlies Impulsivity and Gambling in Parkinson’s. Brain. 2019 Dec 1;142(12):3917-3935. doi: 10.1093/brain/awz327  
  • Isaacs BR, Trutti AC, Pelzer EA, Tittgemeyer M, Temel Y, Forstmann BU, Keuken MC (2019). Cortico-basal white matter alterations occurring in Parkinson's disease. PLoS One. 2019 Aug 19;14(8):e0214343. doi: 10.1371/journal.pone.0214343. eCollection 2019    
  • Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines RF, Papa M, Kiss A, Podesser B, Cassara AM, Tanghe E, Samoudi AM, Tamaud T, Joseph W, Marozas V, Lukosevicius A, Istuk N, Lechner S, Klonowski W, Varoneckas G, Szeles JC, Sarolic A (2019). Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective. Front Neurosci. 2019; 13: 772. Published online 2019 Jul 24. doi: 10.3389/fnins.2019.00772    
  • Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines RF, Papa M, Kiss A, Podesser B, Cassara AM, Tanghe E, Samoudi AM, Tamaud T, Joseph W, Marozas V, Lukosevicius A, Istuk N, Lechner S, Klonowski W, Varoneckas G, Szeles JC, Sarolic A (2019).  Current Directions in the Auricular Vagus Nerve Stimulation I - A Physiological Perspective. Front Neurosci. 2019; 13: 854. Published online 2019 Aug 9. doi: 10.3389/fnins.2019.00854   
  • Pelzer EA, Melzer C, Schönberger A, Hess M, Timmermann L, Eggers C, Tittgemeyer M (2019). Axonal degeneration in Parkinson's disease - Basal ganglia circuitry and D2 receptor availability. Neuroimage Clin. 2019;23:101906. doi: 10.1016/j.nicl.2019.101906. Epub 2019 Jun 21    
  • Edwin Thanarajah S, Iglesias S, Kuzmanovic B, Rigoux L, Stephan KE. Brüning JC, Tittgemeyer M (2019). Modulation of midbrain neurocircuitry by intranasal insulin. Neuroimage. 2019 Jul 1;194:120-127. doi: 10.1016/j.neuroimage.2019.03.050. Epub 2019 Mar 23   
  • Edwin Thanarajah S, Hoffstall V, Rigoux L, Hanssen R, Brüning JC, Tittgemeyer M (2019). The role of insulin sensitivity and intranasally applied insulin on olfactory perception. Sci Rep. 2019 May 10;9(1):7222. doi: 10.1038/s41598-019-43693-7
  • Nettersheim FS, Loehrer PA, Weber I, Jung F, Dembek TA, Pelzer EA, Dafsari HS, Huber CA, Tittgemeyer M, Timmermann L (2019). Dopamine substitution alters effective connectivity of cortical prefrontal, premotor, and motor regions during complex bimanual finger movements in Parkinson's disease. Neuroimage. 2019 Apr 15;190:118-132. doi: 10.1016/j.neuroimage.2018.04.030. Epub 2018 Apr 23  
  • Gliem C, Minnerop M, Roeske S, Gärtner H, Schoene-Bake JC, Adler S, Witt JA, Hoffstaedter F, Schneider-Gold C, Betz RC, Helmstaedter C, Tittgemeyer M, Weber B, Kornblum C (2019). Tracking the brain in myotonic dystrophies: A 5-year longitudinal follow-up study. PLoS ONE. 2019 Mar 7;14(3):e0213381. doi: 10.1371/journal.pone.0213381. eCollection 2019

Achim Tresch

  • T Buch, K Moos, FM Ferreira, H Fröhlich, C Gebhard, A Tresch (2019). Benefits of a factorial design focusing on inclusion of female and male animals in one experiment. J Mol Med (Berl). 2019 Jun;97(6):871-877. doi: 10.1007/s00109-019-01774-0. Epub 2019 Apr 13 

Alexandra Trifunovic

  • Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L (2019). Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep. 2019 Apr;20(4). pii: e47407. doi: 10.15252/embr.201847407. Epub 2019 Mar 18  
  • Herholz M, Cepeda E, Baumann L, Kukat A, Hermeling J, Maciej S, Szczepanowska K, Pavlenko V, Frommolt P, Trifunovic A (2019). KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants. Nat Commun. 2019 Jul 25;10(1):3323. doi: 10.1038/s41467-019-11275-w. PMID:31346165  
  • Lee HJ, Noormohammadi A, Koyuncu S, Calculli G, Simic MS, Herholz M, Trifunovic A, Vilchez D (2019). Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans.Nat Metab. 2019 Aug;1(8):790-810. doi: 10.1038/s42255-019-0097-9. Epub 2019 Aug 19. PMID:31485561 
  • Nemeth CL, Tomlinson SN, Rosen M, O'Brien BM, Larraza O, Jain M, Murray CF, Marx JS, Delannoy M, Fine AS, Wu D, Trifunovic A, Fatemi A (2019). Neuronal ablation of mt-AspRS in mice induces immune pathway activation prior to severe and progressive cortical and behavioral disruption. Exp Neurol. 2020 Apr;326:113164. doi: 10.1016/j.expneurol.2019.113164. Epub 2019 Dec 27. PMID:31887305

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Mirka Uhlirova

  • Mundorf J, Donohoe CD, McClure CD, Southall TD, Uhlirova M (2019). Ets21c governs tissue renewal, stress tolerance, and aging in the Drosophila intestine. Cell Rep. 27, 3019-3033.e5
  • Cosolo A, Jaiswal J, Csordás G, Grass I, Uhlirova M, Classen A (2019). JNK-dependent cell 1 cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress. ELife. 8:e41036. DOI: 10.7554/eLife.41036

Dario Valenzano

  • Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L (2019). Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep. 2019 Apr;20(4). pii: e47407. doi: 10.15252/embr.201847407. Epub 2019 Mar 18
  • Keesey I, Grabe V, Gruber L, Koerte S, Obiero G, Bolton G, Khallaf M, Kunert G, Lavista-Llanos S, Valenzano DR, Rybak J, Barrett B, Knaden M, Hansson B (2019).Inverse resource allocation between vision and olfaction across the genus Drosophila.Nat Commun.2019 Mar 11;10(1):1162. doi: 10.1038/s41467-019-09087-z   
  • Willemsen D, Cui R, Reichard M, Valenzano DR (2019). Intra-species differences in population size shape life history and genome evolution. bioRxiv.  https://doi.org/10.1101/852368 
  • Dolfi L, Ripa R, Antebi A, Valenzano DR, Cellerino A (2019). Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology. EvoDevo. 2019 Nov 8;10:29. doi: 10.1186/s13227-019-0142-5. eCollection 2019  
  • Bradshaw WJ, Valenzano DR (2019). Extreme genomic volatility characterises the evolution of the immunoglobulin heavy chain locus in teleost fishes. bioRxiv.  https://doi.org/10.1101/752063  
  • Aleman FDD, Valenzano DR (2019). Microbiome evolution during host aging. PLoS Pathog. 2019 Jul 25;15(7):e1007727. doi: 10.1371/journal.ppat.1007727. eCollection 2019 Jul   
  • Metge F, Kim Y, Boucas J, Dieterich C, Valenzano DR (2019). Circular RNAs in the ageing African turquoise killifish. bioRxiv. https://doi.org/10.1101/699694 
  • Cui R, Medeiros T, Willemsen D, Iasi LNM, Collier GE, Graef M, Reichard M, Valenzano DR (2019). Relaxed Selection Limits Lifespan by Increasing Mutation Load. Cell. 2019 Jul 11;178(2):385-399.e20. doi: 10.1016/j.cell.2019.06.004. Epub 2019 Jun 27  
  • Bradshaw WJ, Šajina A, Valenzano DR (2019). AEGIS: An In Silico Tool to model Genome Evolution in Age-Structured Populations. bioRxiv. doi.org/10.1101/646877&nbsp;
  • Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Emilse Vargas N, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L (2019). Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart . EMBO Rep. 2019 Apr;20(4). pii: e47407. doi: 10.15252/embr.201847407. Epub 2019 Mar 18   
  • Keesey IW, Grabe V, Gruber L, Koerte S, Obiero GF, Bolton G, Khallaf MA, Kunert G, Lavista-Llanos S, Valenzano DR, Rybak J, Barrett BA, Knaden M, Hansson BS (2019). Inverse resource allocation between vision and olfaction across the genus Drosophila. Nat Commun. 2019 Mar 11;10(1):1162. doi: 10.1038/s41467-019-09087-z             

David Vilchez 

  • Lee HJ, Noormohammadi A, Koyuncu S, Calculli G, Simic M, Herholz M, Trifunovic A,  Vilchez D (2019). Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans.  Nat Metab. 2019 Aug;1(8):790-810. doi: 10.1038/s42255-019-0097-9. Epub 2019 Aug 19  
  • Saez I, Gerbracht J, Koyuncu S, Lee HJ, Horn M, Kroef V, Denzel M, Dieterich C, Gehring N, Vilchez D (2019). The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Lett. 2020 Jan;594(1):175-188. doi: 10.1002/1873-3468.13559. Epub 2019 Aug 8   
  • Fatima A, Gutierrez-Garcia R, Vilchez D (2019). Induced pluripotent stem cells from Huntington's disease patients: a promising approach to define and correct disease-related alterations. Neural Regen Res. 14:769-770

Silvia von Karstedt

  • Mert U, Adawy A, Scharff E, Teichmann P, Willms A, Haselmann V, Colmorgen C, Lemke J, von Karstedt S, Fritsch J, Trauzold A (2019). TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors. Cancers (BASEL). 2019 Aug 14;11(8). pii: E1167. doi: 10.3390/cancers11081167
  • Heilmann T, Vondung F, Borzikowsky C, Szymczak S, Krüger S, Alkatout I, Wenners A, Bauer M, Klapper W, Röcken C, Maass N, von Karstedt S, Schem C, Trauzold A (2019). Heterogeneous intracellular TRAIL-receptor distribution predicts poor outcome in breast cancer patients. J Mol Med (Berl). 2019 Aug;97(8):1155-1167. doi:10.1007/s00109-019-01805-w. Epub 2019 Jun 10         
  • Lim JKM, Delaidelli A, Minaker SW, Zhang HF, Colovic M, Yang H, Negri GL, von Karstedt S, Lockwood WW, Schaffer P, Leprivier G, Sorensen PH (2019). Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9433-9442. doi:10.1073/pnas.1821323116. Epub 2019 Apr 18           
  • Kretz AL, Trauzold A, Hillenbrand A, Knippschild U, Henne-Bruns D, von Karstedt S, Lemke J (2019). TRAILblazing Strategies for Cancer Treatment. Cancers (Basel). 2019 Mar 30;11(4). pii: E456. doi:10.3390/cancers11040456. Review.

Henning Walczak

  • Aalto AL, Mohan AK, Schwintzer L, Kupka S, Kietz C, Walczak H, Broemer M, Meinander A (2019). M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila. Cell Death Differ. 26, pages860–876, 2019  
  • Krishna-Subramanian S, Singer S, Armaka M, Banales JM, Holzer K, Schirmacher P, Walczak H, Kollias G, Pasparakis M, Kondylis V (2019). RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death Differ. 26(12):2710-2726, Epub 2019  
  • Spit M, Rieser E, Walczak H (2019). Linear ubiquitination at a glance. J Cell Sci. 2019 Jan 18;132(2)  Peltzer N, Walczak H (2019). Cell Death and Inflammation - A Vital but Dangerous Liaison. Trends Immunol. 2019 May; 40(5):387-402. doi: 10.1016/j.it.2019.03.006. Epub 2019 Apr 16. Review. PMID: 31003931 
  • Peltzer N, Walczak H (2019). Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy. Dev Cell. Jan 28;48(2):127-128. doi: 10.1016/j.devcel.2019.01.011., 2019

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Sara Wickström 

  • Ou HL, Kim CS, Uszkoreit S, Wickström SA, Schumacher B (2019). Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. Dev Cell. 2019 Jul 22;50(2):167-183.e8. doi: 10.1016/j.devcel.2019.06.012  
  • Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA (2019). Epidermal mTORC2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol. 2020 Jan;145(1):283-300.e8. doi: 10.1016/j.jaci.2019.07.033. Epub 2019 Aug 8  
  • Biggs LC, Kim CS, Miroshnikova YA, Wickström SA (2019). Mechanical forces in the skin: roles in tissue architecture, stability, and function. J Invest Dermatol. 2020 Feb;140(2):284-290. doi: 10.1016/j.jid.2019.06.137. Epub 2019 Jul 18   
  • Miroshnikova YA, Cohen I, Ezhkova E, Wickström SA (2019). Epigenetic gene regulation, chromatin structure and force-induced chromatin remodelling in epidermal development and homeostasis, Curr Opin Genet Dev. 2019 Apr;55:46-51. doi: 10.1016/j.gde.2019.04.014. Epub 2019 May 18   
  • Miroshnikova YA, Hammesfahr T, Wickström SA (2019). Cell biology and mechanopathology of laminopathic cardiomyopathies. J Cell Biol. 218, 393-394

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Rudolf J. Wiesner  

  • Lubomirov LT, Gagov H, Schroeter MM, Wiesner RJ,Franko A (2019). Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1. Physiol Reports. 7:e13975  
  • Aatsinki SM, Elkhwanky MS, Kummu O, Karpale M, Buler M, Viitala P, Rinne V, Mutikainen M, Tavi P, Franko A, Wiesner RJ, Chambers KT, Finck BN, Hakkola J (2019). Fasting-induced transcription factors repress vitamin D bioactivation, a mechanism for vitamin D deficiency in diabetes. Diabetes. 68: 918-93  
  • Holzer T, Probst K, Etich J, Auler M, Georgieva VS,Bluhm B, Frie C, Heilig J, Niehoff A, Nüchel N, Plomann M, Seeger JM, Kashkar H, Baris OR, Wiesner RJ, Brachvogel B (2019). ­­­Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases. J Cell Biol. 218: 1853-1870  
  • Pla-Martin D, Wiesner RJ (2019). Reshaping membranes to build mitochondrial DNA. PLOS Genetics. 15: e1008140  
  • Bugiardini E, Mitchell A, Dalla Rosa I, Hornig-Do HT, Pittman A, Poole O, Holton J, Shah S, Woodward C, Hargreaves I, Quinlivan R, Amunts A, Wiesner RJ, Houlden H, Holt I, Hanna M, Pitceathly R, Spinazzola A (2019). MRP25 mutations impair mitochondrial translation and cause encephalomyopathy. Hum Mol Genet. 28: 2711-2719

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Andreas Wodarz

  • Tiwari MD, Zeitler DM, Meister G, Wodarz A (2019). Molecular profiling of stem cell-like female germ line cells in Drosophila delineates networks important for stemness and differentiation. Biol Open. 2019 Nov 12;8(11). pii: bio046789. doi: 10.1242/bio.046789

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