CECAD

Publications 2020

Adam Antebi

  • A Coch R, Geisler F, Annibal A, Antebi A, E Leube R (2020). Identification of A Novel Link between the Intermediate Filament Organizer IFO-1 and Cholesterol Metabolism in the Caenorhabditis elegans Intestine. Int J Mol Sci. 2020 Nov 3;21(21):E8219. doi: 10.3390/ijms21218219. PMID: 33153048

Thomas Benzing

  • Schermer B, Fabretti F, Damagnez M, Di Cristanziano V, Heger E, Arjune S, Tanner NA, Imhof T, Koch M, Ladha A, Joung J, Gootenberg JS, Abudayyeh OO, Burst V, Zhang F, Klein F, Benzing T, Müller RU (2020). Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay. PLoS One. 2020 Nov 2;15(11):e0238612. doi: 10.1371/journal.pone.0238612. eCollection 2020. PMID: 33137122 Free PMC article
  • Rarek MP, Meyer AM, Pickert L, Pilotto A, Benzing T, Burst V, Polidori MC (2020). The prognostic signature of health-related quality of life in older patients admitted to the emergency department: a 6-month follow-up study. Aging Clin Exp Res. 2020 Nov 1. doi: 10.1007/s40520-020-01732-8. Online ahead of print. PMID: 33135133 
  • Koehler S, Kuczkowski A, Kuehne L, Jüngst C, Hoehne M, Grahammer F, Eddy S, Kretzler M, Beck BB, Höhfeld J, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM (2020). Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis. J Am Soc Nephrol. 2020 Mar;31(3):544-559. doi: 10.1681/ASN.2019030312. Epub 2020 Feb 11. PMID: 32047005  
  • Binz-Lotter J, Jüngst C, Rinschen MM, Koehler S, Zentis P, Schauss A, Schermer B, Benzing T, Hackl MJ (2020). Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling. J Am Soc Nephrol. 2020 Mar;31(3):532-542. doi: 10.1681/ASN.2019020109. Epub 2020 Jan 10. PMID: 31924670 
  • Noetzel N, Meyer AM, Siri G, Pickert L, Heeß A, Verleysdonk J, Benzing T, Pilotto A, Barbe AG, Polidori MC (2020). The impact of oral health on prognosis of older multimorbid inpatients: the 6-month follow up MPI oral health study (MPIOH). Eur Geriatr Med. 2020 Nov 18. doi: 10.1007/s41999-020-00427-7. Online ahead of print. PMID: 33206351 
  • Bruno T, De Nicola F, Corleone G, Catena V, Goeman F, Pallocca M, Sorino C, Bossi G, Amadio B, Cigliana G, Ricciardi MR, Petrucci MT, Spugnini EP, Baldi A, Cioce M, Cortese G, Mattei E, Merola R, Gianelli U, Baldini L, Pisani F, Gumenyuk S, Mengarelli A, Höpker K, Benzing T, Vincenzi B, Floridi A, Passananti C, Blandino G, Iezzi S, Fanciulli M (2020). Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma. Blood Adv. 2020 Nov 24;4(22):5616-5630. doi: 10.1182/bloodadvances.2020002566. PMID: 33186461

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Matteo Bergami

  • Gӧbel J, Engelhardt E, Pelzer P, Sakthivelu V, Jahn HM, Jevtic M, Folz-Donahue K, Kukat C, Schauss A, Frese CK, Giavalisco P, Ghanem A, Conzelmann KK, Motori E, Bergami M (2020). Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. Cell Metab. 2020 Apr 7; 31(4): 791–808.e8.doi: 10.1016/j.cmet.2020.03.005   
  • Ricke KM, Paß T, Kimoloi S, Fährmann K, Jüngst C, Schauss A, Baris OR, Aradjanski M, Trifunovic A, Eriksson Faelker TM, Bergami M, Wiesner RJ (2020). Mitochondrial dysfunction combined with high calcium load leads to impaired antioxidant defense underlying the selective loss of nigral dopaminergic neurons. J Neurosci. 2020 Jan 29. pii: 1345-19. doi: 10.1523/JNEUROSCI.1345-19.2019. [Epub ahead of print] 
  • Bergami M, Motori E (2020). Reweaving the Fabric of Mitochondrial Contact Sites in Astrocytes. Front Cell Dev Biol. 2020 Oct 23;8:592651. doi: 10.3389/fcell.2020.592651. eCollection 2020. PMID: 33195262 Free PMC article.

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Susanne Brodesser

  • Schütter M, Giavalisco P, Brodesser S, Graef M (2020). Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy. Cell. 2020 Jan 9;180(1):135-149.e14. doi: 10.1016/j.cell.2019.12.005 . Epub 2019 Dec 26

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Jens Brüning  

  • Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA (2020). Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol. 2020 Jan;145(1):283-300.e8. doi: 10.1016/j.jaci.2019.07.033. Epub 2019 Aug 8  
  • Engström Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC (2020). NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons. Nat Commun. 2020 Jan 23;11(1):442. doi: 10.1038/s41467-020-14291-3  
  • Turpin-Nolan SM, Brüning JC (2020). The role of ceramides in metabolic disorders: when size and localization matters. Nat Rev Endocrinol. 2020 Feb 14. doi: 10.1038/s41574-020-0320-5. [Epub ahead of print] Review 
  • Mittenbühler MJ, Saedler K, Nolte H, Kern L, Zhou J, Qian SB, Meder L, Ullrich RT, Brüning JC, Wunderlich FT (2020). Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Mol Metab. 2020 Sep 18:101085. doi: 10.1016/j.molmet.2020.101085. Online ahead of print. PMID: 32956847 
  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532 Free PMC article 
  • DiToro D, Harbour SN, Bando JK, Benavides G, Witte S, Laufer VA, Moseley C, Singer JR, Frey B, Turner H, Brüning J, Darley-Usmar V, Gao M, Conover C, Hatton RD, Frank S, Colonna M, Weaver CT (2020). Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity. Immunity. 2020 Apr 14;52(4):650-667.e10. doi: 10.1016/j.immuni.2020.03.013. PMID: 32294406  
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hoevelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling CD, Hartmann E, Rosenwald A, Klapper W, Buettner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt C, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2020). Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood. 2020 Nov 2:blood.2020005734. doi: 10.1182/blood.2020005734. Online ahead of print. PMID: 33140819  
  • Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC (2020). MCH Neurons Regulate Permeability of the Median Eminence Barrier. Neuron. 2020 Jul 22;107(2):306-319.e9. doi: 10.1016/j.neuron.2020.04.020. Epub 2020 May 13. PMID: 32407670 Free PMC article

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Oliver Cornely

  • Koehler P, Mellinghoff SC, Stemler J, Otte F, Berkhoff A, Beste N, Budin S, Cornely FB, Evans JM, Fuchs F, Pesch L, Rebholz AW, Reiner O, Schmitt M, Schuckelt J, Spiertz A, Salmanton-García J, Kron F, Cornely OA (2020). Quantifying guideline adherence in mucormycosis management using the EQUAL score. Mycoses. 2020 Apr;63(4):343-351. doi: 10.1111/myc.13047. Epub 2020 Jan 20. PMID: 31876327  
  • Salmanton-García J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N, Ráčil Z, Falces-Romero I, Ingram P, Benítez-Peñuela MÁ, Rodríguez JY, Desoubeaux G, Barać A, García-Vidal C, Hoenigl M, Mehta SR, Cheng MP, Klyasova G, Heinz WJ, Iqbal N, Krause R, Ostermann H, Penack O, Schalk E, Sheppard DC, Willinger B, Wisplinghoff H, Vehreschild JJ, Cornely OA, Vehreschild MJGT; FungiScope® ECMM/ISHAM Working Group. Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn). J Antimicrob Chemother. 2019 Nov 1;74(11):3315-3327. doi: 10.1093/jac/dkz344. PMID: 31393591 Clinical Trial 
  • Aguilar RC, Salmanton-García J, Carney J, Böll B, Kochanek M, Jazmati N, Cornely OA, Vehreschild MJGT (2020). Clostridioides difficile infections in the intensive care unit: a monocentric cohort study. Infection. 2020 Jun;48(3):421-427. doi: 10.1007/s15010-020-01413-8. Epub 2020 Mar 24. PMID: 32212102 Free PMC article 
  • Kron F, Wingen-Heimann SM, Jeck J, Lazzaro C, Cornely OA, Thielscher C (2020). Principal-agent theory-based cost and reimbursement structures of isavuconazole treatment in German hospitals. Mycoses. 2020 Oct 9. doi: 10.1111/myc.13192. Online ahead of print. PMID: 33034927 
  • Steenwyk JL, Mead ME, de Castro PA, Valero C, Damasio A, Dos Santos RAC, Labella AL, Li Y, Knowles SL, Raja HA, Oberlies NH, Zhou X, Cornely OA, Fuchs F, Koehler P, Goldman GH, Rokas A (2020). Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus. bioRxiv. 2020 Nov 6:2020.11.06.371971. doi: 10.1101/2020.11.06.371971. Preprint. PMID: 33173866 Free PMC article 
  • Lanternier F, Seidel D, Pagano L, Styczynski J, Mikulska M, Pulcini C, Maertens J, Munoz P, Garcia-Vidal C, Rijnders B, Arendrup MC, Sabino R, Verissimo C, Gaustad P, Klimko N, Arikan-Akdagli S, Arsic V, Barac A, Skiada A, Klingspor L, Herbrecht R, Donnelly P, Cornely OA, Lass-Flörl C, Lortholary O (2020). Invasive pulmonary aspergillosis treatment duration in haematology patients in Europe: An EFISG, IDWP-EBMT, EORTC-IDG and SEIFEM survey. Mycoses. 2020 May;63(5):420-429. doi: 10.1111/myc.13056. Epub 2020 Mar 4. PMID: 32009262 
  • Jenks JD, Seidel D, Cornely OA, Chen S, van Hal S, Kauffman C, Miceli MH, Heinemann M, Christner M, Jover Sáenz A, Burchardt A, Kemmerling B, Herbrecht R, Steinmann J, Shoham S, Gräber S, Pagano L, Deeren D, Slavin MA, Hoenigl M (2020). Clinical characteristics and outcomes of invasive Lomentospora prolificans infections: Analysis of patients in the FungiScope® registry. Mycoses. 2020 May;63(5):437-442. doi: 10.1111/myc.13067. Epub 2020 Apr 15. PMID: 32080902

Martin Denzel

  • Sawarkar R, Scherz-Shouval R, Denzel MS, Saarikangas J (2020). Chaperoning junior faculty: Institutional support and guidance can relieve challenges for early-career group leaders and improve academic performance. EMBO Rep. 2019 Jan;20(1). pii: e47163. doi: 10.15252/embr.201847163. Epub 2018 Nov 23    

Alexander Dilthey

  • Walker A, Houwaart T, Wienemann T, Vasconcelos MK, Strelow D, Senff T, Hulse L, Adams O, Andree M, Hauka S, Feldt T, Jensen BE, Keitel V, Kindgen-Milles D, Timm J, Pfeffer K, Dilthey AT (2020). Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020. Euro Surveill. 2020 Jun 4; 25(22): 2000746
  • Dilthey AT, Meyer SA, Kaasch AJ (2020). Ultraplexing: increasing the efficiency of long-read sequencing for hybrid assembly with k-mer-based multiplexing. Genome Biol. 2020; 21: 68.  

Sabine Eming

  • Kakanj P, Eming SA, Partridge L, Leptin M (2020). Long-term in vivo imaging of Drosophila larvae. Nat Protoc. 2020 Feb 10. doi: 10.1038/s41596-019-0282-z. [Epub ahead of print]

Mafalda Escobar-Henriques 

  • Kuwana T, King LE, Cosentino K, Suess J, García-Sáez AJ, Gilmore AP, Newmeyer DD (2020). Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization. J Biol Chem. 2020 Jan 3. pii: jbc.RA119.011635. doi: 10.1074/jbc.RA119.011635. [Epub ahead of print]
  • Schuster R, Anton V, SimoesT, Altin S, den Brave F, Hermanns T, Hospenthal M, Komander D, Dittmar G, Dohmen RJ, Escobar-Henriques M (2020). Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation. Life Sci Alliance. 2020 Jan; 3(1): e201900476. Published online 2019 Dec 19 
  • Escobar-Henriques M, Anton V (2020). Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion. Int J Mol Sci. 2020 Sep 18;21(18):E6841. doi: 10.3390/ijms21186841. PMID: 32961852 Review.

Lukas P. Frenzel

  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hoevelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling CD, Hartmann E, Rosenwald A, Klapper W, Buettner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt C, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2020). -Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood. 2020 Nov 2:blood.2020005734. doi: 10.1182/blood.2020005734. Online ahead of print. PMID: 33140819

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Henning Fenselau

  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532 Free PMC article.

 

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Ana J. Garcia-Saez

  • Peña-Blanco A, Haschka MD, Jenner A, Zuleger T, Proikas-Cezanne T, Villunger A, García-Sáez AJ (2020). Drp1 modulates mitochondrial stress responses to mitotic arrest. Cell Death Differ. 2020 Mar 19. doi: 10.1038/s41418-020-0527-y . [Epub ahead of print]  
  • Kuwana T, King LE, Cosentino K, Suess J, Garcia-Saez AJ, Gilmore AP, Newmeyer DD (2020). Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization. J Biol Chem. 2020 Feb 7;295(6):1623-1636. doi: 10.1074/jbc.RA119.011635. Epub 2020 Jan 3
  • Flores-Romero H, Ros U, García-Sáez AJ (2020). A lipid perspective on regulated cell death. Int Rev Cell Mol Biol. 2020;351:197-236. doi:10.1016/bs.ircmb.2019.11.004. Epub 2019 Dec 18 
  • García-Sáez AJ (2020). The BCL-2 family saga. Nat Rev Mol Cell Biol. 2020 Jul 22. doi: 10.1038/s41580-020-0276-2. Online ahead of print  
  • Diestelkoetter-Bachert P, Beck R, Reckmann I, Hellwig A, Garcia-Saez A, Zelman-Hopf M, Hanke A, Nunes Alves A, Wade RC, Mayer MP, Wieland F (2020). Structural characterization of an Arf dimer interface: molecular mechanism of Arf-dependent membrane scission. FEBS Lett. 2020 Jul;594(14):2240-2253. PMID: 32394429 DOI: 10.1002/1873-3468.13808  
  • Ros U, Pedrera L, Garcia-Saez AJ (2020). Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis. Int J Mol Sci. 2020 Mar 31;21(7):2412. PMID: 32244433 PMCID: PMC7177786 DOI: 10.3390/ijms21072412  
  • Flores-Romero H, García-Sáez AJ (2020). Lipids glue BAK dimers together. Nat Struct Mol Biol. 2020 Sep 29. doi: 10.1038/s41594-020-00516-y.Online ahead of print. PMID: 32994578 No abstract available 
  • Lindenboim L, Grozki D, Amsalem-Zafran AR, Peña-Blanco A, Gundersen GG, Borner C, Hodzic D, Garcia-Sáez AJ, Worman HJ, Stein R (2020). Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins. Cell Death Discov. 2020 Sep 18;6:90. doi: 10.1038/s41420-020-00327-6. eCollection 2020. PMID: 33024575 Free PMC article 
  • Flores-Romero H, Ros U, Garcia-Saez AJ (2020). Pore formation in regulated cell death. EMBO J. 2020 Oct 30:e105753. doi: 10.15252/embj.2020105753. Online ahead of print. PMID: 33124082 Review.

Martin Graef

  • Schütter M, Giavalisco P, Brodesser S, Graef M (2020). Local fatty acid channeling into phospholipid synthesis drives phagophore expansion during autophagy. Cell. 2020 Jan 9;180(1):135-149.e14. doi: 10.1016/j.cell.2019.12.005. Epub 2019 Dec 26  
  • Gross A, Graef M (2020). Mechanisms of autophagy in metabolic stress response. J Mol Biol. 2020 Jan 3;432(1):28-52. doi: 10.1016/j.jmb.2019.09.005. Epub 2019 Oct 15

Michael Hallek

  • Tzaridis T, Reiners KS, Weller J, Bachurski D, Schäfer N, Schaub C, Hallek M, Scheffler B, Glas M, Herrlinger U, Wild S, Coch C, Hartmann G (2020). Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature. Int J Mol Sci. 2020 Sep 29;21(19):E7211. doi: 10.3390/ijms21197211. PMID: 33003586 
  • Herling CD, Cymbalista F, Groß-Ophoff-Müller C, Bahlo J, Robrecht S, Langerbeins P, Fink AM, Al-Sawaf O, Busch R, Porcher R, Cazin B, Dreyfus B, Ibach S, Leprêtre S, Fischer K, Kaiser F, Eichhorst B, Wentner CM, Hoechstetter MA, Döhner H, Leblond V, Kneba M, Letestu R, Böttcher S, Stilgenbauer S, Hallek M, Levy V (2020). Early treatment with FCR versus watch and wait in patients with stage Binet A high-risk chronic lymphocytic leukemia (CLL): a randomized phase 3 trial. Leukemia. 2020 Aug;34(8):2038-2050. doi: 10.1038/s41375-020-0747-7. Epub 2020 Feb 18. PMID: 32071431 Free PMC article
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hoevelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling CD, Hartmann E, Rosenwald A, Klapper W, Buettner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt C, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2020). -Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood. 2020 Nov 2:blood.2020005734. doi: 10.1182/blood.2020005734. Online ahead of print. PMID: 33140819

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Thorsten Hoppe    

  • Herzog LK, Kevei É, Marchante R, Böttcher C, Bindesbøll C, Lystad AH, Pfeiffer A, Gierisch ME, Salomons FA, Simonsen A, Hoppe T, Dantuma NP (2020). The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy. Aging Cell e13051.
  • Fatima A, Irmak D, Noormohammadi A, Rinschen MM, Das A, Leidecker O, Schindler C, Sánchez-Gaya V, Wagle P, Pokrzywa W, Hoppe T, Rada-Iglesias A, Vilchez D (2020). The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Commun Biol. 3: 262.
  • Ravanelli S, den Brave F, and Hoppe T (2020). Mitochondrial quality control governed by ubiquitin. Front Cell Dev Biol. 8: 270.
  • Balaji V, Hoppe T (2020). Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly. F1000 Biol Rep 9: 88
  • Bayer EA, Stecky RC, Neal L, Katsamba PS, Ahlsen G, Balaji V, Hoppe T, Shapiro L, Oren-Suissa M, Hobert O (2020). Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior. Elife. 2020 Oct 6;9:e59614. doi: 10.7554/eLife.59614. PMID: 33021200 Free PMC article  

Frank Jessen

  • Wang X, Huang W, Su L, Xing Y, Jessen F, Sun Y, Shu N, Han Y (2020). Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease. Mol Neurodegener. 2020 Sep 22;15(1):55. doi: 10.1186/s13024-020-00395-3. PMID: 32962744 Review
  • Jessen F, Kleineidam L, Wolfsgruber S, Bickel H, Brettschneider C, Fuchs A, Kaduszkiewicz H, König HH, Mallon T, Mamone S, Pabst A, Pentzek M, Roehr S, Weeg D, Jochen W, Weyerer S, Wiese B, Maier W, Scherer M, Riedel-Heller S, Wagner M (2020). Prediction of dementia of Alzheimer type by different types of subjective cognitive decline. Alzheimers Dement. 2020 Nov 2. doi: 10.1002/alz.12163. Online ahead of print. PMID: 33140565 
  • Maier F, Spottke A, Bach JP, Bartels C, Buerger K, Dodel R, Fellgiebel A, Fliessbach K, Frölich L, Hausner L, Hellmich M, Klöppel S, Klostermann A, Kornhuber J, Laske C, Peters O, Priller J, Richter-Schmidinger T, Schneider A, Shah-Hosseini K, Teipel S, von Arnim CAF, Wiltfang J, Jessen F (2020). Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020 May 1;3(5):e206027. doi: 10.1001/jamanetworkopen.2020.6027. PMID: 32463470 Free PMC article. Clinical Trial  
  • Sannemann L, Schild AK, Altenstein S, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Freiesleben SD, Glanz W, Heneka MT, Janowitz D, Kilimann I, Kobeleva X, Laske C, Metzger CD, Munk MHJ, Perneczky R, Peters O, Polcher A, Priller J, Rauchmann B, Rösch C, Rudolph J, Schneider A, Spottke A, Spruth EJ, Teipel S, Vukovich R, Wagner M, Wiltfang J, Wolfsgruber S, Duezel E, Jessen F; DELCODE Study Group (2020). Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers-results from the DELCODE study. Alzheimers Res Ther. 2020 Oct 16;12(1):131. doi: 10.1186/s13195-020-00701-7. PMID: 33066827 Free PMC article.

Hamid Kashkar      

  • Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H (2020). Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat Microbiol. 2020 Feb;5(2):354-367. doi: 10.1038/s41564-019-0620-5 . Epub 2019 Dec 23

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Peter Kloppenburg

  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532 Free PMC article.

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Natalia Kononenko

  • Negrete-Hurtado A, Overhoff M, Bera S, De Bruyckere E, Schätzmüller K, Kye MJ, Qin C, Lammers M, Kondylis V, Neundorf I, Kononenko N (2020). Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons. Nat Commun. 2020; 11: 1535. Published online 2020 Mar 24. doi: 10.1038/s41467-020-15287-9  
  • Overhoff M, De Bruyckere E, Kononenko NL (2020). Mechanisms of neuronal survival safeguarded by endocytosis and autophagy. J Neurochem. 2020 Sep 22. doi: 10.1111/jnc.15194. Online ahead of print. PMID: 32964462

Tatiana Korotkova

  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532 Free PMC article

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Martin Krönke

  • Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H (2020). Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat Microbiol. 2020 Feb;5(2):354-367. doi: 10.1038/s41564-019-0620-5 . Epub 2019 Dec 23  
  • Hos NJ, Fischer J, Hos D, Hejazi Z, Calabrese C, Ganesan R, Murthy AMV, Rybniker J, Kumar S, Krönke M, Robinson N (2020). TRIM21 Is Targeted for Chaperone-Mediated Autophagy during SalmonellaTyphimurium Infection.  J Immunol. 2020 Sep 18:ji2000048. doi: 10.4049/jimmunol.2000048. Online ahead of print. PMID: 32948684

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Marcus Krüger

  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hoevelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling CD, Hartmann E, Rosenwald A, Klapper W, Buettner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt C, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2020). -Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood. 2020 Nov 2:blood.2020005734. doi: 10.1182/blood.2020005734. Online ahead of print. PMID: 33140819

Michael Lammers 

  • Negrete-Hurtado A, Overhoff M, Bera S, De Bruyckere E, Schätzmüller K, Kye MJ, Qin C, Lammers M, Kondylis V, Neundorf I, Kononenko N (2020). Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons. Nat Commun. 2020; 11: 1535. Published online 2020 Mar 24. doi: 10.1038/s41467-020-15287-9 

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Maria Leptin

  • Kakanj P, Eming SA, Partridge L, Leptin M (2020). Long-term in vivo imaging of Drosophila larvae. Nat Protoc. 2020 Feb 10. doi: 10.1038/s41596-019-0282-z. [Epub ahead of print]
  • de Medeiros G, Rauzi M, Kromm D, Balazs B, Norlin N, Günther S, Izquierdo E, Ronchi P, Komoto S, Schwab Y, Peri F, de Renzis S, Leptin M, Hufnagel L (2020). Cell and tissue manipulation with  ultrashort infrared laser pulses in light-sheet microscopy. Sci Rep. 2020 Feb 6;10(1):1942. doi: 10.1038/s41598-019-54349-x.

Roman-Ulrich Müller

  • Schermer B, Fabretti F, Damagnez M, Di Cristanziano V, Heger E, Arjune S, Tanner NA, Imhof T, Koch M, Ladha A, Joung J, Gootenberg JS, Abudayyeh OO, Burst V, Zhang F, Klein F, Benzing T, Müller RU (2020). Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay. PLoS One. 2020 Nov 2;15(11):e0238612. doi: 10.1371/journal.pone.0238612. eCollection 2020. PMID: 33137122 Free PMC article 
  • Johnsen M, Kubacki T, Yeroslaviz A, Späth MR, Mörsdorf J, Göbel H, Bohl K, Ignarski M, Meharg C, Habermann B, Altmüller J, Beyer A, Benzing T, Schermer B, Burst V, Müller RU (2020). The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury. J Am Soc Nephrol. 31 (2020), 716–730. doi.org/10.1681/ASN.2019050534
  • Wahba R, Vitinius F, Walczuch B, Dieplinger G, Buchner D, Datta R, Lürssen N, Schlößer HA, Thomas M, Müller RU, Kann M, Hellmich M, Kurschat C, Stippel DL (2020). Hand-Assisted Retroperitoneoscopic Donor Nephrectomy Compared to Anterior Approach Open Donor Nephrectomy: Improved Long-Term Physical Component Score in Health-Related Quality of Life in Living Kidney Donors. Transplant Proc. (2020) doi.org/10.1016/j.transproceed.2020.08.026
  • Grundmann F, Müller RU, Hoyer-Allo KJR, Späth MR, Passmann E, Becker I, Pfister R, Baldus S, Benzing T, Burst V (2020). Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial. Sci Rep 10 (2020), 5202. doi.org/10.1038/s41598-020-61895-2
  • Janssens P, Jouret F, Bammens B, Liebau MC, Schaefer F, Dandurand A, Perrone RD, Müller RU, Pao CS, Mekahli D (2020). Implications of early diagnosis of autosomal dominant polycystic kidney disease: A post hoc analysis of the TEMPO 3:4 trial. Sci Rep. 10 (2020), 4294. doi.org/10.1038/s41598-020-61303-9
  • Siedek F, Grundmann F, Weiss K, Pinto Dos Santos D, Arjune S, Haneder S, Persigehl T, Müller RU, Baessler B (2020). Magnetic Resonance Kidney Parenchyma-T2 as a Novel Imaging Biomarker for Autosomal Dominant Polycystic Kidney Disease. Invest Radiol. (2020) doi.org/10.1097/RLI.0000000000000633

 

Carien Niessen

  • Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA (2020). Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020 Apr 9. pii: S0092-8674(20)30345-7. doi: 10.1016/j.cell.2020.03.052 . [Epub ahead of print]
  • Green KJ, Roth-Carter Q, Niessen CM, Nichols SA (2020). Tracing the Evolutionary Origin of Desmosomes. Curr Biol. 2020 May 18;30(10):R535-R543. doi: 10.1016/j.cub.2020.03.047. PMID: 3242849
  • Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA (2020). Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052. Epub 2020 Apr 16. PMID: 32302590 Free article.
  • Sahu P, Sussman DM, Rübsam M, Mertz AF, Horsley V, Dufresne ER, Niessen CM, Marchetti MC, Manning ML, Schwarz JM (2020). Small-scale demixing in confluent biological tissues. Soft Matter. 2020 Apr 1;16(13):3325-3337. doi: 10.1039/c9sm01084j. PMID: 32196025
  • Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Utermöhlen O, Krönke M, Niessen CM (2020). Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis. J Invest Dermatol. 2020 Feb 22:S0022-202X(20)30160-3. doi: 10.1016/j.jid.2020.02.006. Online ahead of print. PMID: 32092351
  • Bayliss R, Wheeldon J, Caucheteux SM, Niessen CM, Piguet V (2020). Identification of Host Trafficking Genes Required for HIV-1 Virological Synapse Formation in Dendritic Cells. J Virol. 2020 Apr 16;94(9):e01597-19. doi: 10.1128/JVI.01597-19. Print 2020 Apr 16. PMID: 32075937 Free PMC article.
  • Polányi L, Niessen CM, Vohlen C, Stinn J, Kretschmer T, Jentgen V, Hirani D, Koningsbruggen-Rietschel SV, Dötsch J, Alejandre Alcazar MA (2020). Intrauterine growth restriction induces skin inflammation, increases TSLP and impairs epidermal barrier function. J Mol Med (Berl). 2020 Feb;98(2):279-289. doi: 10.1007/s00109-019-01867-w. Epub 2020 Jan 7. PMID: 31912169

 

Linda Partridge

  • Kakanj P, Eming SA, Partridge L, Leptin M (2020). Long-term in vivo imaging of Drosophila larvae. Nat Protoc. 2020 Feb 10. doi: 10.1038/s41596-019-0282-z. [Epub ahead of print]

Manolis Pasparakis  

  • Naito MG, Xu D, Amin P, Lee J, Wang H, Li W, Kelliher M, Pasparakis M, Yuan J (2020). Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proc Natl Acad Sci U S A. 2020 Feb 18. pii: 201916427. doi: 10.1073/pnas.1916427117. [Epub ahead of print]   
  • Schwarzer R, Laurien L, Pasparakis M (2020). New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8. Curr Opin Cell Biol. 2020 Mar 9;63:186-193. doi: 10.1016/j.ceb.2020.02.004 . [Epub ahead of print]   
  • Jiao H, Wachsmuth L, Kumari S, Schwarzer R, Lin J, Eren RO, Fisher A, Lane R, Young GR, Kassiotis G, Kaiser WJ, Pasparakis M (2020). Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature. 2020 Apr;580(7803):391-395. doi: 10.1038/s41586-020-2129-8 . Epub 2020 Mar 25  
  • Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, Bongiovanni L, de Bruin A, Scott CL, Saeys Y, Pasparakis M, Bertrand MJM, van Loo G (2020). OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis. Cell Rep. 2020 Feb 18;30(7):2237-2247.e6. doi: 10.1016/j.celrep.2020.01.028 
  • Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M (2020). FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity. 2020 Apr 22. pii: S1074-7613(20)30160-6. doi: 10.1016/j.immuni.2020.04.002. [Epub ahead of print]
  • Laurien L, Nagata M, Schünke H, Delanghe T, Wiederstein JL, Kumari S, Schwarzer R, Corona T, Krüger M, Bertrand MJM, Kondylis V, Pasparakis M (2020). Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nat Commun. 2020 Apr 8;11(1):1747. doi: 10.1038/s41467-020-15466-8 
  • Priem D, Devos M, Druwé S, Martens A, Slowicka K, Ting AT, Pasparakis M, Declercq W, Vandenabeele P, van Loo G, Bertrand MJM (2020). A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and –independent mechanisms. Cell Death Dis. 2019 Sep 18;10(10):692. doi: 10.1038/s41419-019-1937 y.PMID: 31534131 Free PMC article 
  • Priem D, Devos M, Druwé S, Martens A, Slowicka K, Ting AT, Pasparakis M, Declercq W, Vandenabeele P, van Loo G, Bertrand MJM (2020). A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms.  Cell Death Dis. 2019 Sep 18;10(10):692. doi: 10.1038/s41419-019-1937-y. PMID: 31534131 Free PMC article 
  • Krishna-Subramanian S, Singer S, Armaka M, Banales JM, Holzer K, Schirmacher P, Walczak H, Kollias G, Pasparakis M, Kondylis V (2020). RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death Differ. 2019 Dec;26(12):2710-2726. doi: 10.1038/s41418-019-0330-9. Epub 2019 Apr 15. PMID: 30988397 Free PMC article.

Christina Polidori

  • La Colla L, Polidori MC, Di Saverio G, Preziosi G, Mantovani L, Caobelli F (2020). The impact of health worker gap in Italy on the COVID-19 pandemic. A good time to improve the quality of the Italian National Health System (NHS)? J Infect Public Health. 2020 Sep;13(9):1253-1254. doi: 10.1016/j.jiph.2020.06.010. Epub 2020 Jun 15. PMID: 32586683 Free PMC article. No abstract available 
  • Rarek MP, Meyer AM, Pickert L, Pilotto A, Benzing T, Burst V, Polidori MC (2020). The prognostic signature of health-related quality of life in older patients admitted to the emergency department: a 6-month follow-up study. Aging Clin Exp Res. 2020 Nov 1. doi: 10.1007/s40520-020-01732-8. Online ahead of print. PMID: 33135133 
  • Noetzel N, Meyer AM, Siri G, Pickert L, Heeß A, Verleysdonk J, Benzing T, Pilotto A, Barbe AG, Polidori MC (2020). The impact of oral health on prognosis of older multimorbid inpatients: the 6-month follow up MPI oral health study (MPIOH). Eur Geriatr Med. 2020 Nov 18. doi: 10.1007/s41999-020-00427-7. Online ahead of print. PMID: 33206351 
  • Meyer AM, Wiebe L, Faust M, Chiapponi C, Brinkkötter PT, Polidori MC, Bartram MP (2020). [Cognitive disorder, depression and gait disturbance in an internal medicine patient-geriatric syndromes in an acute care hospital]. Z Gerontol Geriatr. 2020 Nov 13. doi: 10.1007/s00391-020-01811-5. Online ahead of print. PMID: 33185719 German. No abstract available
  • Meyer AM, Becker I, Siri G, Brinkkötter PT, Benzing T, Pilotto A, Polidori MC (2020). The prognostic significance of geriatric syndromes and resources. Aging Clin Exp Res. 2020; 32(1):115-124
  • Pilotto A, Custodero C, Cella A, Polidori MC, Maggi S, Ferrucci L (2020). A multidimensional approach to frailty in older people. Ageing Res Rev. 2020 Mar 21;60:101047
  • Dias I, Polidori MC, Griffiths HR (2020). Inflammation, lipid peroxidation and redox regulation. Antioxidants and Redox Signaling, Forum Issue “Inflammation”. Inflammation and related diseases: redox-based mechanisms and energy management. Antioxid Redox Signal. 2020 Feb 28
  • Meyer AM, Podolski N, Pickert L, Polidori MC (2020). Strategies to prevent age-related cognitive decline.Dtsch Med Wochenschr. 2020 Feb;145(3):146-150
  • Cruz-Jentoft AJ, Daragjati J, Fratiglioni L, Maggi S, Mangoni AA, Mattace-Raso F, Paccalin M, Polidori MC, Topinkova E, Ferrucci L, Pilotto A on behalf of the MPI_AGE Investigators (2020). New Horizons in Comprehensive Geriatric Assessment: the Multidimensional Prognostic Index (MPI). Results and Recommendations from the MPI_AGE Project. Aging Clin Exp Res. 2020 Mar 16
  • Ungar A, Rivasi G, Petrovic M, Schönenberger A, Martínez-Sellés M, Gasowski J, Bahat-Ozturk G, Bo M, Dallmaier D, Fumagalli S, Grodzicki T, Kotovskaya Y, Maggi S, Raso FM, Polidori MC, Rajkumar R, Strandberg T, Werner N, Benetos A; From the EuGMS Special Interest Group on Cardiovascular Medicine (2020). Toward a geriatric approach to patients with advanced age and cardiovascular diseases: position statement of the EuGMS Special Interest Group on Cardiovascular Medicine.Eur Geriatr Med. 2020 Feb;11(1):179-184
  • Polidori MC, Maggi S, Mattace Raso F, Pilotto A (2020). The unavoidable costs of frailty: a geriatric perspective in the time of COVID-19. Geriatric Care. 2020; 6: 8989
  • Custodero C, Cella A, Veronese N, Azzini M, Fimognari F, Mattace-Raso F, Polidori MC, Sabbà C, Pilotto A. (2020). The Multidimensional Prognostic Index (MPI) for the prognostic stratification of hospitalized older patients with COVID-19: a prospective multicenter observational cohort study. Objectives, study design and expected outcomes (MPI_COVID-19). Geriatric Care.doi.org/10.4081/gc.2020.9038
  • Jacobs AH, Emmert K, Baron R, Bartsch T, Bauer J, Becker C, Berg D, Bergmann P, Boetzel K, Bollheimer C, Deuschl G, Djukic M, Drey M,  Durwen H, Ebersbach G, Elshehabi M, Geritz J, Gisinger C, Guennewig T,  Hauptmann B, Heppner HJ, Hobert MA, Hofmann W, Huellemann P, Jahn K, Klucken J, Kurth R, Lindner R, Lingor P, Lukas A, Maetzold S, Mokrusch T, Mollenhauer B, Nau R, Plate A, Polidori MC, Prell T, Schellinger P, Schuetze S, Spira D, Stephani U, Studt S, Trenkwalder C, Unger HL, Urban P, von Arnim C, Warnecke T, Weiss M, Wiedemann A, Wirth R, Witt K, Dodel R, Maetzler W (2020). Neurogeriatrics – a vision for improved care and research for geriatric patients with leading neurological disabilities. Z Gerontol Geriatr. 2020 (53) 340-346
  • Falkenreck JM, Roheger M,Weigert H,Friese A,Jahr P, Becker I,Nelles G,Kalbe E,Polidori MC (2020). BrainProtect® - a cognitive training program with nutritional and physical counseling components: a retrospective analysis of its effects in healthy individuals. Geriatric Care. doi.org/10.4081/gc.2020.9328
  • Polidori MC Section Editor. Ageing Medicine and Geriatrics. In: Encyclopedia of Gerontology and Population Aging. Gu D and Dupre M Eds. Springer 2020
  • Senin U, Polidori MC, Cherubini A, Mecocci P (2020). Paziente Anziano Paziente Geriatrico Medicina della Complessitá. Fondamenti di Gerontologia e Geriatria. Eds. 4th Edition, Edises, Napoli 2020

Hans Christian Reinhardt

  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hoevelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling CD, Hartmann E, Rosenwald A, Klapper W, Buettner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt C, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2020). -Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood. 2020 Nov 2:blood.2020005734. doi: 10.1182/blood.2020005734. Online ahead of print. PMID: 33140819

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Nirmal Robinson

  • Hos NJ, Fischer J, Hos D, Hejazi Z, Calabrese C, Ganesan R, Murthy AMV, Rybniker J, Kumar S, Krönke M, Robinson N (2020). TRIM21 Is Targeted for Chaperone-Mediated Autophagy during SalmonellaTyphimurium Infection.  J Immunol. 2020 Sep 18:ji2000048. doi: 10.4049/jimmunol.2000048. Online ahead of print. PMID: 32948684

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Björn Schumacher

  • Lopes AFC, Bozek K, Herholz M, Trifunovic A, Rieckher M, Schumacher B (2020). A C. elegans model for neurodegeneration in Cockayne syndrome. Nucleic Acids Res. 2020, gkaa795, doi.org/10.1093/nar/gkaa795  
  • Meyer DH, Schumacher B (2020). A transcriptome based aging clock near the theoretical limit of accuracy. BioRxiv 2020; doi: doi.org/10.1101/2020.05.29.123430   
  • Umansky C, Morellato A, Scheidegger M, Rieckher M, Martinefski MR, Fernandez GA, Kolesnikova K, Vesting AJ, Karakasilioti I, Reingruber H, Wei Y, He R, Bollini M, Monge ME, Schumacher B, Pontel LB (2020). Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption. BioRxiv 2020; dio doi.org/10.1101/2020.05.14.090738    
  • Bansal A, Neuhaus R, Izquierdo-Alvarez E, Vorholt D, Feldkötter H, Nolte H, Lohneis P, Büttner R, Krüger M, Pallasch CP, Schumacher B (2020). ATM-mediated DNA damage response in macrophages primes phagocytosis and immune checkpoint regulation. BioRxiv 2020; doi: doi.org/10.1101/2020.03.14.987438   
  • Chatzidoukaki O, Goulielmaki E, Schumacher B, Garinis GA (2020). DNA Damage Response and Metabolic Reprogramming in Health and Disease. Trends Genet. 2020 Jul 16:S0168-9525(20)30166-9- doi.org/10.1016/j.tig.2020.06.018  
  • Wang S, Meyer DH, Schumacher B (2020). H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Nat Struct Mol Biol. (2020). doi.org/10.1038/s41594-020-00513-1 

Alexandra Trifunovic

  • Ricke KM, Paß T, Kimoloi S, Fährmann K, Jüngst C, Schauss A, Baris OR, Aradjanski M, Trifunovic A, Eriksson Faelker TM, Bergami M, Wiesner RJ (2020). Mitochondrial dysfunction combined with high calcium load leads to impaired antioxidant defense underlying the selective loss of nigral dopaminergic neurons. J Neurosci. 2020 Jan 29. pii: 1345-19. doi: 10.1523/JNEUROSCI.1345-19.2019. [Epub ahead of print] PMID:32005765 
  • Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A (2020). A salvage pathway maintains highly functional respiratory complex I. Nat Commun. 2020 Apr 2;11(1):1643. doi: 10.1038/s41467-020-15467-7 
  • Nemeth CL, Tomlinson SN, Rosen M, O'Brien BM, Larraza O, Jain M, Murray CF, Marx JS, Delannoy M, Fine AS, Wu D, Trifunovic A, Fatemi A (2020). Neuronal ablation of mt-AspRS in mice induces immune pathway activation prior to severe and progressive cortical and behavioral disruption. Exp Neurol. 2020 Apr;326:113164. doi: 10.1016/j.expneurol.2019.113164. Epub 2019 Dec 27. PMID:31887305 
  • Shytaj IL, Lucic B, Forcato M, Penzo C, Billingsley J, Laketa V, Bosinger S, Stanic M, Gregoretti F, Antonelli L, Oliva G, Frese CK, Trifunovic A, Galy B, Eibl C, Silvestri G, Bicciato S, Savarino A, Lusic M (2020). Alterations of redox and iron metabolism accompany the development of HIV latency. EMBO J. 2020 May 4;39(9):e102209. doi: 10.15252/embj.2019102209. Epub 2020 Mar 11. PMID:32157726; PMCID: PMC7196916 
  • Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC (2020). GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab. 2020 Jun 2;31(6):1189-1205.e13. doi: 10.1016/j.cmet.2020.05.001. Epub 2020 May 19. PMID:32433922; PMCID: PMC7272126  
  • Hofsetz E, Demir F, Szczepanowska K, Kukat A, Kizhakkedathu JN, Trifunovic A, Huesgen PF (2020). The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis. Mol Cell Proteomics. 2020 Aug;19(8):1330-1345. doi:10.1074/mcp.RA120.002082. Epub 2020 May 28. PMID: 32467259 
  • Lopes AFC, Bozek K, Herholz M, Trifunovic A, Rieckher M, Schumacher B (2020). A C. elegans model for neurodegeneration in Cockayne syndrome. Nucleic Acids Res. 2020 Oct 6:gkaa795. doi: 10.1093/nar/gkaa795. Online ahead of print. PMID: 33021672

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Mirka Uhlirova

  • Csordás G, Grawe F, Uhlirova M (2020). Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments. Elife. 2020 Oct 7;9:e57297. doi: 10.7554/eLife.57297.PMID: 33026342  
  • Stanković D, Claudius AK, Schertel T, Bresser T, Uhlirova M (2020). A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8. Dis Model Mech. 2020 Jun 26;13(6):dmm043174. doi: 10.1242/dmm.043174

Silvia von Karstedt

  • Bebber CM, Müller F, Prieto Clemente L, Weber J, von Karstedt S (2020). Ferroptosis in Cancer Cell Biology. Cancers (Basel). 2020 Jan 9;12(1):164. doi: 10.3390/cancers12010164.PMID: 31936571
  • von Karstedt S, Walczak H (2020). An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer. Cell Death Dis. 2020 Mar 17;6:14. doi: 10.1038/s41420-020-0249-4. eCollection 2020.PMID: 32194994

Henning Walczak

  • Müller I, Strozyk E, Schindler S, Beissert S, Oo HZ, Sauter T, Lucarelli P, Raeth S, Hausser A, Al Nakouzi N, Fazli L, Gleave ME, Liu H, Simon HU, Walczak H, Green DR, Bartek J, Daugaard M, Kulms D (2020). Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. Mol Cell. 77(5):970-984, Epub 2020  
  • Annibaldi A, Walczak H (2020). Death Receptors and Their Ligands in Inflammatory Disease and Cancer. CSH PERSPECT BIOL. a036384 [Epub ahead of print], 2020 
  • von Karstedt S, Walczak H (2020). An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer. Cell Death Dis. 6:14, 2020

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Sara Wickström

  • Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA (2020). Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020 Apr 9. pii: S0092-8674(20)30345-7. doi: 10.1016/j.cell.2020.03.052 . [Epub ahead of print]

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Rudolf J. Wiesner

  • Ricke KM, Paß T, Kimoloi S, Fährmann K, Jüngst C, Schauss A, Baris OR, Aradjanski M, Trifunovic A, Eriksson Faelker TM, Bergami M, Wiesner RJ (2020). Mitochondrial dysfunction combined with high calcium load leads to impaired antioxidant defense underlying the selective loss of nigral dopaminergic neurons. J Neurosci. 31 January 2020,  1345-19; DOI: doi.org/10.1523/JNEUROSCI.1345-19.2019

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Andreas Wodarz

  • Witte L, Linnemannstoens K, Schmidt K, Honemann-Capito M, Grawe F, Wodarz A, Gross JC (2020). Kinesin motor Klp98A mediates apical to basal Wg transport. Development. 2020 Jul 14:dev.186833. doi: 10.1242/dev.186833 
  • Linnemannstöns K, Witte L, Karuna P, Kittel J, Danieli A, Müller D, Nitsch L, Honemann-Capito M, Grawe F, Wodarz A, Gross JC (2020). Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium. Development. 2020 Jul 1:dev.185421. doi: 10.1242/dev.185421
  • Hohmann C, Pfister R, Mollenhauer M, Adler C, Kozlowski J, Wodarz A, Drebber U, Wippermann J, Michels G (2020). Inflammatory cell infiltration in left atrial appendageal tissues of patients with atrial fibrillation and sinus rhythm. Sci Rep. 2020 Feb 3;10(1):1685. doi: 10.1038/s41598-020-58797-8

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Thomas Wunderlich

  • Mittenbühler MJ, Saedler K, Nolte H, Kern L, Zhou J, Qian SB, Meder L, Ullrich RT, Brüning JC, Wunderlich FT (2020). Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Mol Metab. 2020 Sep 18:101085. doi: 10.1016/j.molmet.2020.101085. Online ahead of print. PMID: 32956847  
  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532 Free PMC article 
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hoevelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling CD, Hartmann E, Rosenwald A, Klapper W, Buettner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt C, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2020). -Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood. 2020 Nov 2:blood.2020005734. doi: 10.1182/blood.2020005734. Online ahead of print. PMID: 33140819

 

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Branko Zevnik

  • Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Büning H, Yang L, Cao H, Jesus DF, Kulkarni RN, Zevnik B, Troder SE, Knippschild U, Edwards PA, Lee RG, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim TQA, Kornfeld JW (2020). A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism. Nat Commun. 11(1): 644. doi: 10.1038/s41467-020-14323-y

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