Marcus Buschbeck, JCLRI: "Histone variants link metabolism and 3D chromatin architecture"

Time:    Thursday, May 9th, 2019, 3.00pm

Venue:  MPI for Biology of Ageing, Joseph-Stelzmann-Str. 9b, auditorium, ground floor

Host:    Peter Tessarz, MPI Age

Further information:
Marcus Buschbeck’s research focuses on the link between metabolism and epigenetic regulation and the regulation and molecular function of histone variants. Recently, his group identified  macroH2A1.1 an isoform of the histone variant macroH2A to be part of a molecular mechanism allowing cells to couple metabolic requirements of nucleus and mitochondria. They showed that macroH2A1.1 binds nuclear PARP1 and dampens its NAD+ consumption creating a buffer of NAD+ precursors facilitating NAD+ dependent reactions in mitochondria.