The Research Areas at CECAD
CECAD aims to reveal the mechanisms that underlie the aging process and its associated diseases. Aging affects a large variety of physiological processes ranging from molecular and cellular signaling mechanisms to systemic adaptations of the aging organism.

The overarching long-term scientific mission of CECAD is to develop effective, evidence-based prevention strategies for major aging-associated diseases, with the aim to extend the healthy lifespan and to mantain quality of life during aging.
Based on breakthrough discoveries of CECAD scientists in the previous funding periods, CECAD has expanded its scope beyond the analysis of cell-autonomous stress signaling pathways to the investigation of the role of inter-organ communication and the integration of internal signals and external environmental cues in the aging process. CECAD scientists are exploring the key mechanisms of aging in three defined research areas.
Supporting these three research areas, CECAD has successfully established three research platforms:
- Technology and technology development, comprising the CECAD facilities that implement state-of-the-art methodologies
- Translational research
- Education and Career Development, Diversity, Gender Equality and Family Programs, and Public Outreach and Visibility
CECAD 4.0 focuses on aging as a process shaped by molecular systems, stress responses, and the environment. The three Research Areas work closely together to understand the mechanisms that determine resilience, healthspan, and disease vulnerability.
Current Research Areas (CECAD 4.0)

Research Area 1
Molecular, cellular, and inter-tissue networks in organismal aging
RA1 investigates how cells maintain protein and organelle quality throughout life. By uncovering how cellular balance breaks down with age, RA1 identifies molecular targets to preserve function and delay decline.

Research Area 2
Beneficial and maladaptive stress signaling in aging and aging-associated diseases
RA2 studies how cells and tissues respond to stress. The aim is to understand when stress responses support repair and adaptation, and when they drive inflammation and degeneration.

Research Area 3
Environmental factors, sexual dimorphism, and transgeneration in organismal aging trajectories
RA3 explores how diet, microbiome, sex-specific biology, and parental factors shape individual aging trajectories. This research identifies modifiable factors that influence health across the lifespan and across generations.
RA-1 Head Principal Investigators

Prof. Dr. Aleksandra Trifunovic
Principal Investigator
Head of Research Area 1
Telefon+49 221 478 842 91
E-Mailaleksandra.trifunovic[at]uk-koeln.de
CECAD Research Center
Universität zu Köln
Joseph-Stelzmann-Str. 26
50931 Köln

Prof. Dr. David Vilchez
Principal Investigator
Head of Research Area 1
Telefon+49 221 478 84172
E-Maildvilchez[at]uni-koeln.de
RA-2 Head Principal Investigators

Prof. Dr. Christian Frezza
Principal Investigator
Alexander von Humboldt Professor of Metabolomics in Aging
Head of Research Area 2
Telefon+49 221 478 84308
E-Mailchristian.frezza[at]uni-koeln.de
Metabolomics in aging
Room: 4.068
CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Köln

Dr. Anne Schaefer
Principal Investigator
Director of MPI for Biology of Ageing
Head of Research Area 2
Telefon+49 221 37970 702
RA-3 Head Principal Investigators

Prof. Dr. Filipe Gomes Cabreiro
Principal Investigator
Head of Research Area 3
Telefon+49 221 478 84390

Prof. Dr. Tatiana Korotkova
Principal Investigator
Institute Director
Head of Research Area 3
Telefon+49 221 4786950