Publikationen 2021

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Adam Antebi

  • Schiffer I, Gerisch B, Kawamura K, Laboy R, Hewitt J, Denzel MS, Mori MA, Vanapalli S, Shen Y, Symmons O, Antebi A(2021). miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging. Elife. 2021 Jul 27;10:e66768. doi: 10.7554/eLife.66768. PMID: 34311841; PMCID: PMC8315803. 
  • Ellwood RA, Hewitt JE, Torregrossa R, Philp AM, Hardee JP, Hughes S, van de Klashorst D, Gharahdaghi N, Anupom T, Slade L, Deane CS, Cooke M, Etheridge T, Piasecki M, Antebi A, Lynch GS, Philp A, Vanapalli SA, Whiteman M, Szewczyk NJ (2021). Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2018342118. doi: 10.1073/pnas.2018342118. PMID: 33627403
  • Allmeroth K, Kim CS, Annibal A, Pouikli A, Koester J, Derisbourg MJ, Andrés Chacón-Martínez C, Latza C, Antebi A, Tessarz P, Wickström SA, Denzel MS. N1-acetylspermidine is a determinant of hair follicle stem cell fate. J Cell Sci. 2021 May 1;134(9):jcs252767. doi: 10.1242/jcs.252767. Epub 2021 May 11. PMID: 33973637. 
  • Annibal A, Tharyan RG, Schonewolff MF, Tam H, Latza C, Auler MMK, Grönke S, Partridge L, Antebi A(2021). Author Correction: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity. Nat Commun. 2021 Aug 12;12(1):5025. doi: 10.1038/s41467-021-24840-z. Erratum for: Nat Commun. 2021 Jun 9;12(1):3486. PMID: 34385439; PMCID: PMC8361093. 
  • Antebi, A. (2021). NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin. Febs Open Bio11, 59-59.
  • Dolfi L, Suen TK, Ripa R, Antebi A (2021). Sperm cryopreservation and in vitro fertilization techniques for the African turquoise killifish Nothobranchius furzeri. Sci Rep. 2021 Aug 25;11(1):17145. doi: 10.1038/s41598-021-96383-8. PMID: 34433853.
  • Annibal A, Ripa R, Ballhysa E, Latza C, Hochhard N, Antebi A (2021). Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo. Anal Bioanal Chem. 2021 Sep 2:1-12. doi: 10.1007/s00216-021-03628-6. Online ahead of print. PMID: 34476522
  • Klionsky, D.J., Abdel-Aziz, A.K., Abdelfatah, S., […], Antas, P., Antebi, A., Anton, Z., […] , W., Brand-Saberi, B., Dong, X.C., Kenchappa, C.S., Li, Z., Lin, Y., Oshima, S., Rong, Y., Sluimer, J.C., Stallings, C.L., and Tong, C.K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy17, 1-382. 10.1080/15548627.2020.1797280.
  • Lengefeld J, Cheng CW, Maretich P, Blair M, Hagen H, McReynolds MR, Sullivan E, Majors K, Roberts C, Kang JH, Steiner JD, Miettinen TP, Manalis SR, Antebi A, Morrison SJ, Lees JA, Boyer LA, Yilmaz ÖH, Amon A (2021). Cell size is a determinant of stem cell potential during aging.Sci Adv. 2021 Nov 12;7(46):eabk0271. doi: 10.1126/sciadv.abk0271. Epub 2021 Nov 12. PMID: 34767451 

Miguel A. Alejandre Alcazar

  • Voggel, J., Lubomirov, L., Lechner, F., Fink, G., Nüsken, E., Wohlfarth, M., Pfitzer, G., Shah-Hosseini, K., Hellmich, M., Alcázar, M.A.A., Dötsch, J., and Nüsken, K.D. (2021). Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction. Am J Physiol-Renal321, F93-F105. 10.1152/ajprenal.00653.2020.
  • Kuiper-Makris C, Selle J, Nüsken E, Dötsch J, Alejandre Alcazar MA. Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases. Front Med (Lausanne). 2021 Jun 15;8:667315. doi: 10.3389/fmed.2021.667315. PMID: 34211985; PMCID: PMC8239134.
  • Vohlen C, Mohr J, Fomenko A, Kuiper-Makris C, Grzembke T, Aydogmus R, Wilke R, Hirani D, Dötsch J, Alejandre Alcazar MA (2021). Dynamic Regulation of GH-IGF1 Signaling in Injury and Recovery in Hyperoxia-Induced Neonatal Lung Injury. Cells. 2021 Oct 29;10(11):2947. doi: 10.3390/cells10112947.PMID: 34831169
  • Thomassen JC, Trojan T, Lippach G, Rietschel E, Alejandre Alcázar MA*, van Koningsbruggen-Rietschel S* (2021). Inflammatory markers in sputum - P. aeruginosa is an important trigger of airway inflammation in cystic fibrosis. European Respiratory Journal (ERJ) Open Res. 2021 Jul 19;7(3):00636-2020. doi: 10.1183/23120541.00636-2020.  *shared last authorship. PMID: 34291109
  • Berghausen E, Janssen W, Vantler M, Behringer B, Joseph C, Zierden M, ten Freyhaus H, Klinke A, Baldus S, Alejandre Alcázar M.A., Savai R, Pullamsetti S, Zhao J, Schermuly R, Rosenkranz S (2021). p110α is a Central Target in Pulmonary Hypertension. Journal of Clinical Investigation (JCI). 2021 Oct 1;131(19):e136939. doi: 10.1172/JCI136939. PMID: 34596056

Hisham Bazzi

  • Phan TP, Maryniak AL, Boatwright CA, Lee J, Atkins A, Tijhuis A, Spierings DC, Bazzi H, Foijer F, Jordan PW, Stracker TH, Holland AJ (2021). Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway. EMBO J. 2021 Jan 4;40(1):e106118. doi: 10.15252/embj.2020106118. Epub 2020 Nov 23   
  • Xiao C, Grzonka M, Meyer-Gerards C, Mack M, Figge R, Bazzi H (2021). Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development. EMBO Rep. 2021 Jan 7:e51127. doi: 10.15252/embr.202051127. Online ahead of print. PMID: 33410253 
  • Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD, Bazzi H (2021). High proliferation and delamination during skin epidermal stratification. Nat Commun. 2021 May 28;12(1):3227. doi: 10.1038/s41467-021-23386-4. PMID: 34050161; PMCID: PMC8163813. 
  • Damen, M., Wirtz, L., Soroka, E., Khatif, H., Kukat, C., Simons, B., and Bazzi, H. (2021). A two-phase model of epidermal stratification: Lessons from centrosomes. J Invest Dermatol141, S26-S26.
  • Khatif, H., and Bazzi, H. (2021). Generation of Dkk4-Cre knock-in mice to study morphogenesis of ectodermal appendages. J Invest Dermatol141, S105-S105.
  • Khatif, H., and Bazzi, H. (2021). The Wnt-inhibitor is required for primary hair follicle induction and patterning. J Invest Dermatol141, S204-S204.
  • Crispatzu G, Rehimi R, Pachano T, Bleckwehl T, Cruz-Molina S, Xiao C, Mahabir E, Bazzi H, Rada-Iglesias A (2021). The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo. Nat Commun. 2021 Jul 16;12(1):4344. doi: 10.1038/s41467-021-24641-4. PMID: 34272393; PMCID: PMC8285398.
  • Wirtz, L., and Bazzi, H. (2021). A burst of progenitor proliferation drives epidermal stratification. J Invest Dermatol141, S165-S165.

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Thomas Benzing

  • Pickert L, Meyer AM, Becker I, Heeß A, Noetzel N, Brinkkötter P, Pilotto A, Benzing T, Polidori MC (2021). Role of a multidimensional prognosis in-hospital monitoring for older patients with prolonged stay. Int J Clin Pract. 2021 Jan 6:e13989. doi: 10.1111/ijcp.13989. Online ahead of print. PMID: 33406298 
  • Polidori MC, Sies H, Ferrucci L, Benzing T (2021). COVID-19 mortality as a fingerprint of biological age. Ageing Res Rev. 2021 May;67:101308. doi: 10.1016/j.arr.2021.101308. Epub 2021 Feb 20. PMID: 33621704; PMCID: PMC7896489. 
  • Benzing T, Salant D (2021). Insights into Glomerular Filtration and Albuminuria. N Engl J Med. 2021 Apr 15;384(15):1437-1446. doi: 10.1056/NEJMra1808786. PMID: 33852781.
  • Talyan S, Filipów S, Ignarski M, Smieszek M, Chen H, Kühne L, Butt L, Göbel H, Hoyer-Allo KJR, Koehler FC, Altmüller J, Brinkkötter P, Schermer B, Benzing T, Kann M, Müller RU, Dieterich C. CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease. Cells. 2021 Mar 20;10(3):692. doi: 10.3390/cells10030692. PMID: 33804736; PMCID: PMC8003990.
  • He B, Chen P, Zambrano S, Dabaghie D, Hu Y, Möller-Hackbarth K, Unnersjö-Jess D, Korkut GG, Charrin E, Jeansson M, Bintanel-Morcillo M, Witasp A, Wennberg L, Wernerson A, Schermer B, Benzing T, Ernfors P, Betsholtz C, Lal M, Sandberg R, Patrakka J. Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes. Nat Commun. 2021 Apr 9;12(1):2141. doi: 10.1038/s41467-021-22331-9. PMID: 33837218; PMCID: PMC8035407. 
  • Hoyer-Allo KJR, Späth MR, Hanssen R, Johnsen M, Brodesser S, Kaufmann K, Kiefer K, Koehler FC, Göbel H, Kubacki T, Grundmann F, Schermer B, Brüning J, Benzing T, Burst V, Müller RU (2021). Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. Int J Mol Sci. 2021 May 22;22(11):5485. doi: 10.3390/ijms22115485. PMID: 34067475; PMCID: PMC8196977. 
  • Lagolio E, Demurtas J, Buzzetti R, Cortassa G, Bottone S, Spadafora L, Cocino C, Smith L, Benzing T, Polidori MC (2021). A rapid and feasible tool for clinical decision making in community-dwelling patients with COVID-19 and those admitted to emergency departments: the Braden-LDH-HorowITZ Assessment-BLITZ. Intern Emerg Med. 2021 Jul 28:1–6. doi: 10.1007/s11739-021-02805-w. Epub ahead of print. PMID: 34322832; PMCID: PMC8318055.
  • Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B (2021). Maintaining proteostasis under mechanical stress. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. PMID: 34309183. 
  • Butt L, Unnersjö-Jess D, Höhne M, Schermer B, Edwards A, Benzing T (2021). A mathematical estimation of the physical forces driving podocyte detachment. Kidney Int. 2021 Jul 29:S0085-2538(21)00728-6. doi: 10.1016/j.kint.2021.06.040. Epub ahead of print. PMID: 34332959.
  • Mangold N, Pippin J, Unnersjoe-Jess D, Koehler S, Shankland S, Brähler S, Schermer B, Benzing T,Brinkkoetter PT, Hagmann H (2021). The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development. Cells. 2021 Sep 18;10(9):2464. doi: 10.3390/cells10092464. PMID: 34572114.
  • Kühne L, Völker LA, Hagmann H, Hägele H, Osterholt T, Eichenauer DA, Thomas A, Breuer J, Grüttner B, Gottschalk I, Kann M, Benzing T, Thevis M, Müller AM, Brinkkoetter PT (2021). First use of the anti-VWF nanobody caplacizumab to treat iTTP in pregnancy. Br J Haematol. 2021 Sep 29. doi: 10.1111/bjh.17833. Online ahead of print. PMID: 34585743 
  • Heeß A, Meyer AM, Becker I, Noetzel N, Verleysdonk J, Rarek M, Benzing T, Polidori MC (2021). The prognostic fingerprint of quality of life in older inpatients : Relationship to geriatric syndromes' and resources' profile. Z Gerontol Geriatr. 2021 Oct 6. doi: 10.1007/s00391-021-01978-5. Online ahead of print. PMID: 34617144 
  • Noetzel N, Meyer AM, Siri G, Pickert L, Heeß A, Verleysdonk J, Benzing T, Pilotto A, Barbe AG, Polidori MC (2021). The impact of oral health on prognosis of older multimorbid inpatients: the 6-month follow up MPI oral health study (MPIOH). Eur Geriatr Med. 2021 Apr;12(2):263-273. doi: 10.1007/s41999-020-00427-7. Epub 2020 Nov 18. PMID: 33206351
  • Seufert L, Benzing T, Ignarski M, Müller RU (2021). RNA-binding proteins and their role in kidney disease.Nat Rev Nephrol. 2021 Nov 3. doi: 10.1038/s41581-021-00497-1. Online ahead of print. PMID: 34732838
  • Reusch B, Bartram MP, Dafinger C, Palacio-Escat N, Wenzel A, Fenton RA, Saez-Rodriguez J, Schermer B, Benzing T, Altmüller J, Beck BB, Rinschen MM (2021). MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells. J Proteomics. 2021 Nov 11:104424. doi: 10.1016/j.jprot.2021.104424. Online ahead of print. PMID: 34775100
  • Höhfeld J., Benzing T., Bloch, W. Fürst D.O., Gehlert S., Hesse M., Hoffmann B., Hoppe T., Huesgen P.F., Köhn M., Kolanus W., Merkel R., NIessen C.M., Pokrzywa W., Rinschen M.M., Wachten D., Warscheid B. (2021). Maintaining proteostasis under mechanical stress. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507.Epub 2021 Jul 26.
  • Affeldt P, Koehler FC, Brensing KA, Adam V, Burian J, Butt L, Gies M, Grundmann F, Hinrichs S, Johannis W, Kalisch N, Meyer-Delpho M, Oehm S, Platen E, Schöler C, Heger E, Steger G, Stippel D, Ziegelhöfer A, Benzing T, Klein F, Kurschat C, Müller R-U*, Cristanziano VD(2021). Immune Responses to SARS-CoV-2 Infection and Vaccination in Dialysis Patients and Kidney Transplant Recipients. Microorganisms. 2022; 10(1):4. https://doi.org/10.3390/microorganisms10010004
  • Koehler S, Odenthal J, Ludwig V, Jess DU, Höhne M, Jüngst C, Grawe F, Helmstädter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HHH, Walz G, Bloch W, Niessen C, Schermer B, Wodarz A, Denholm B, Benzing T,Iden S, Brinkkoetter PT(2021). Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier. Kidney Int. 2021 Dec 17:S0085-2538(21)01150-9. doi: 10.1016/j.kint.2021.11.030. Epub ahead of print. PMID: 34929254.
  • Affeldt, P., Di Cristanziano, V., Grundmann, F., Wirtz, M., Kaiser, R., Benzing, T., Stippel, D., Kann, M., and Kurschat, C. (2021). Monitoring of hepatitis E virus RNA during treatment for chronic hepatitis E virus infection after renal transplantation. Immun Inflamm Dis9, 513-520. 10.1002/iid3.411.
  • Dafinger, C., Benzing, T., Dotsch, J., Schermer, B., and Liebau, M.C. (2021). Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality. Mol Cell Pediatr8, 1. 10.1186/s40348-021-00111-1.
  • Di Cristanziano, V., Affeldt, P., Burkert, K., Dieplinger, G., Kann, M., Grundmann, F., Benzing, T., Ortwin, A., Kaiser, R., Stippel, D., Kurschat, C., Klein, F., and Müller, R.U. (2021). Monitoring of Antiviral Immune Response as an Indicator of Immunosuppression Intensity and Outcome after Kidney Transplantation: The Vireno Study. Transpl Int34, 63-63.
  • Edwards, A., Salant, D., and Benzing, T. (2021). Insights into Glomerular Filtration and Albuminuria. Reply. N Engl J Med385, 478. 10.1056/NEJMc2108129.
  • Kann, M., and Benzing, T. (2021). Update 2021: COVID-19 from a Nephrology Perspective. Deut Med Wochenschr146, 915-917. 10.1055/a-1449-5068.
  • Rarek, M.P., Meyer, A.M., Pickert, L., Pilotto, A., Benzing, T., Burst, V., and Polidori, M.C. (2021). The prognostic signature of health-related quality of life in older patients admitted to the emergency department: a 6-month follow-up study. Aging Clin Exp Res33, 2203-2211. 10.1007/s40520-020-01732-8.
  • Unnersjo-Jess, D., Butt, L., Hohne, M., Witasp, A., Kuhne, L., Hoyer, P.F., Patrakka, J., Brinkkotter, P.T., Wernerson, A., Schermer, B., Benzing, T., Scott, L., Brismar, H., and Blom, H. (2021). A fast and simple clearing and swelling protocol for 3D in-situ imaging of the kidney across scales. Kidney Int99, 1010-1020. 10.1016/j.kint.2020.10.039.

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Matteo Bergami

  • Bergami, M. (2021). Mitochondrial network dynamics in reactive astrocytes. Glia69, E73-E74.
  • Klionsky, D.J., Abdel-Aziz, A.K., […], Bergami, M., Bergmann, A., […], W., Brand-Saberi, B., Dong, X.C., Kenchappa, C.S., Li, Z., Lin, Y., Oshima, S., Rong, Y., Sluimer, J.C., Stallings, C.L., and Tong, C.K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy17, 1-382. 10.1080/15548627.2020.1797280.
  • Malo, M.C., Göbel, J., Jahn, H., Schilasky, E., Motori, E., Jevtic, M., and Bergami, M. (2021). Deciphering the role of mitochondria-ER contactsin reactive astrocytes. Glia69, E160-E160.
  • Schilasky, E., Göbel, J., Müller, S., Altmüller, J., and Bergami, M. (2021). NEMO differentially affects astrocytes and microglia by NF-κB-dependent and -independent functions following brain injury. Glia69, E485-E486.

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Andreas Beyer

  • Lackner A, Sehlke R, Garmhausen M, Giuseppe Stirparo G, Huth M, Titz-Teixeira F, van der Lelij P, Ramesmayer J, Thomas HF, Ralser M, Santini L, Galimberti E, Sarov M, Stewart AF, Smith A, Beyer A, Leeb M (2021). Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency. EMBO J. 2021 Mar 9:e105776. doi: 10.15252/embj.2020105776. Online ahead of print. PMID: 33687089
  • Tain LS, Sehlke R, Meilenbrock RL, Leech T, Paulitz J, Chokkalingam M, Nagaraj N, Grönke S, Fröhlich J, Atanassov I, Mann M, Beyer A, Partridge L. Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. Elife. 2021 Apr 21;10:e67275. doi: 10.7554/eLife.67275. PMID: 33879316; PMCID: PMC8060030.
  • Tognetti M, Gabor A, Yang M, Cappelletti V, Windhager J, Rueda OM, Charmpi K, Esmaeilishirazifard E, Bruna A, de Souza N, Caldas C, Beyer A, Picotti P, Saez-Rodriguez J, Bodenmiller B. Deciphering the signaling network of breast cancer improves drug sensitivity prediction. Cell Syst. 2021 Apr 27:S2405-4712(21)00111-3. doi: 10.1016/j.cels.2021.04.002. Epub ahead of print. PMID: 33932331.
  • He F, Steige KA, Kovacova V, Göbel U, Bouzid M, Keightley PD, Beyer A, de Meaux J (2021). Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity. Nat Commun. 2021 Jun 7;12(1):3376. doi: 10.1038/s41467-021-23558-2. PMID: 34099660; PMCID: PMC8184852. 
  • Santini L, Halbritter F, Titz-Teixeira F, Suzuki T, Asami M, Ma X, Ramesmayer J, Lackner A, Warr N, Pauler F, Hippenmeyer S, Laue E, Farlik M, Bock C, Beyer A, Perry ACF, Leeb M (2021). Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3. Nat Commun. 2021 Jun 21;12(1):3804. doi: 10.1038/s41467-021-23510-4. PMID: 34155196.
  • Charmpi K, Chokkalingam M, Johnen R, Beyer A (2021). Optimizing network propagation for multi-omics data integration. PLoS Comput Biol. 2021 Nov 11;17(11):e1009161. doi: 10.1371/journal.pcbi.1009161. Online ahead of print. PMID: 34762640
  • Cappelletti V, Hauser T, Piazza I, Pepelnjak M, Malinovska L, Fuhrer T, Li Y, Dörig C, Boersema P, Gillet L, Grossbach J, Dugourd A, Saez-Rodriguez J, Beyer A, Zamboni N, Caflisch A, de Souza N, Picotti P (2021). Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ. Cell (20)31691-3. doi: 10.1016/j.cell.2020.12.021. PMID: 33357446

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Jens Brüning  

  • Porniece Kumar M, Cremer AL, Klemm P, Steuernagel L, Sundaram S, Jais A, Hausen AC, Tao J, Secher A, Pedersen TÅ, Schwaninger M, Wunderlich FT, Lowell BB, Backes H, Brüning JC (2021).Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab. 2021 Dec;3(12):1662-1679. doi: 10.1038/s42255-021-00499-0. Epub 2021 Dec 20. PMID: 34931084 
  • Borgmann D, Ciglieri E, Biglari N, Brandt C, Cremer AL, Backes H, Tittgemeyer M, Wunderlich FT, Brüning JC, Fenselau H (2021). Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab. 2021 May 21:S1550-4131(21)00219-9. doi: 10.1016/j.cmet.2021.05.002. Epub ahead of print. PMID: 34043943.
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hövelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Büttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2021). Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood. 2021 Feb 4;137(5):646-660. doi: 10.1182/blood.2020005734. PMID: 33538798
  • Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC(2021). Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 May 17. doi: 10.1038/s41593-021-00854-0. Epub ahead of print. PMID: 34002087.
  • Aravamudhan S, Türk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, König T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E, Trifunovic A, Brüning JC, Langer T, Braun T, Krüger M (2021).Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. J Mol Cell Cardiol. Feb 5;154:41-59. doi: 10.1016/j.yjmcc.2021.01.010.Online ahead of print.
  • Hanssen, R, Kretschmer AC, Rigoux L, Albus K, Edwin Thanarajah S, Sitnikow T, Melzer C, Cornely OA, Brüning JC, Tittgemeyer M (2021). GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans. Mol Metab. Jan 14;45:101163. doi: 10.1016/j.molmet.2021.101163. Online ahead of print 
  • Dodd GT, Kim SJ, Méquinion M, Xirouchaki CE, Brüning JC, Andrews ZB, Tiganis T (2021). Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance. Sci Adv. 2021 Feb 26;7(9):eabf4100. doi: 10.1126/sciadv.abf4100. Print 2021 Feb. PMID: 33637536 
  • Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschöp MH, Diano S, Brüning JC, Cota D (2021). POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat Metab. 2021 Feb 25. doi: 10.1038/s42255-021-00345-3. Online ahead of print. PMID: 33633406 Review. 
  • Hoyer-Allo KJR, Späth MR, Hanssen R, Johnsen M, Brodesser S, Kaufmann K, Kiefer K, Koehler FC, Göbel H, Kubacki T, Grundmann F, Schermer B, Brüning J, Benzing T, Burst V, Müller RU (2021). Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. Int J Mol Sci. 2021 May 22;22(11):5485. doi: 10.3390/ijms22115485. PMID: 34067475; PMCID: PMC8196977.
  • Jais A, Brüning JC (2021). Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus. Endocr Rev. 2021 Sep 7: bnab025. doi: 10.1210/endrev/bnab025. Online ahead of print. PMID: 34490882
  • Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC (2021). Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun. 2021 Sep 2;12(1):5249. doi: 10.1038/s41467-021-25380-2. PMID: 34475397
  • Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021 Oct 25:S1550-4131(21)00482-4. doi: 10.1016/j.cmet.2021.10.004. Online ahead of print. PMID: 34715039
  • Matsushita M, Awazawa M, Kobayashi N, Ikushima YM, Soeda K, Tamura-Nakano M, Muratani M, Kobayashi K, Blüher M, Brüning JC, Ueki K (2021). An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. Cell Chem Biol. 2021 Dec 21:S2451-9456(21)00522-5. doi: 10.1016/j.chembiol.2021.12.008. Epub ahead of print. PMID: 34986326.
  • Welcker, D., Stein, C., Feitosa, N.M., Armistead, J., Zhang, J.L., Lütke, S., Kleinridders, A., Brüning, J.C., Eming, S.A., Sengle, G., Niehoff, A., Bloch, W., and Hammerschmidt, M. (2021). Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions. Sci Rep-Uk11. ARTN 17926. 10.1038/s41598-021-96824-4.

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Filipe Cabreiro

  • Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, Hövelmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, Sévin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR (2021). Bioaccumulation of therapeutic drugs by human gut bacteria. Nature. 2021 Sep 8. doi: 10.1038/s41586-021-03891-8. Online ahead of print. PMID: 34497420
  • Martinez-Miguel VE, Lujan C, Espie-Caullet T, Martinez-Martinez D, Moore S, Backes C, Gonzalez S, Galimov ER, Brown AEX, Halic M, Tomita K, Rallis C, von der Haar T, Cabreiro F, Bjedov I (2021). Increased fidelity of protein synthesis extends lifespan. Cell Metab. 2021 Sep 8: S1550-4131(21)00417-4. doi: 10.1016/j.cmet.2021.08.017. Online ahead of print. PMID: 34525330

Oliver Cornely

  • Koehler P, Cornely OA, Kochanek M (2021). Bronchoscopy safety precautions for diagnosing COVID-19 associated pulmonary aspergillosis-A simulation study. Mycoses. 2021 Jan;64(1):55-59. doi: 10.1111/myc.13183. Epub 2020 Sep 26. PMID: 32918497
  • Budin S, Salmanton-García J, Koehler P, Stemler J, Cornely OA, Mellinghoff SC (2021). Validation of the EQUAL Aspergillosis Score by analysing guideline-adherent management of invasive pulmonary aspergillosis.J Antimicrob Chemother. 2021 Jan 4:dkaa518. doi: 10.1093/jac/dkaa518. Online ahead of print. PMID: 33394007
  • Chen SC, Halliday CL, Hoenigl M, Cornely OA, Meyer W (2021). Scedosporium and LomentosporaInfections: Contemporary Microbiological Tools for the Diagnosis of Invasive Disease. J Fungi (Basel).2021 Jan 4;7(1):E23. doi: 10.3390/jof7010023. PMID: 33406673 Review.
  • van Werkhoven CH, Ducher A, Berkell M, Mysara M, Lammens C, Torre-Cisneros J, Rodríguez-Baño J, Herghea D, Cornely OA, Biehl LM, Bernard L, Dominguez-Luzon MA, Maraki S, Barraud O, Nica M, Jazmati N, Sablier-Gallis F, de Gunzburg J, Mentré F, Malhotra-Kumar S, Bonten MJM, Vehreschild MJGT; ANTICIPATE Study Group. Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics. Nat Commun. 2021 Apr 14;12(1):2240. doi: 10.1038/s41467-021-22269-y. PMID: 33854064.
  • Hanssen R, Kretschmer AC, Rigoux L, Albus K, Thanarajah SE, Sitnikow T, Melzer C, Cornely OA, Brüning JC, Tittgemeyer M (2021). GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans. Mol Metab.2021 Jan 13:101163. doi: 10.1016/j.molmet.2021.101163. Online ahead of print. PMID: 33453418
  • Christopeit M, Schmidt-Hieber M, Sprute R, Buchheidt D, Hentrich M, Karthaus M, Penack O, Ruhnke M, Weissinger F, Cornely OA, Maschmeyer G (2021). Prophylaxis, diagnosis and therapy of infections in patients undergoing high-dose chemotherapy and autologous haematopoietic stem cell transplantation. 2020 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol.2021 Feb;100(2):321-336. doi: 10.1007/s00277-020-04297-8. Epub 2020 Oct 20. PMID: 33079221
  • Wunsch S, Zurl C, Strohmaier H, Meinitzer A, Rabensteiner J, Posch W, Lass-Flörl C, Cornely O, Pregartner G, König E, Feierl G, Hoenigl M, Prattes J, Zollner-Schwetz I, Valentin T, Krause R (2021). Longitudinal Evaluation of Plasma Cytokine Levels in Patients with Invasive Candidiasis. J Fungi (Basel).2021 Feb 1;7(2):101. doi: 10.3390/jof7020101. PMID: 33535593
  • Banck JC, Mueller N, Mellinghoff SC, Thelen M, Fraccaroli A, Blumenberg V, Koehler P, Kunz WG, Rudelius M, Schrötzlmair F, Subklewe M, Schlößer HA, Tischer J, Cornely OA, Lindner LH, von Bergwelt-Baildon M (2021). Immune Checkpoint Blockade for Aspergillosis and Mucormycosis Coinfection. Hemasphere. 2021 Feb 10;5(3):e530. doi: 10.1097/HS9.0000000000000530. eCollection 2021 Mar. PMID: 33604513
  • Hoenigl M, Levitz SM, Schuetz AN, Zhang SX, Cornely OA (2021). All You Need to Know and More about the Diagnosis and Management of Rare Mold Infections. mBio. 2021 Feb 23;12(1):e02920-20. doi: 10.1128/mBio.02920-20. PMID: 33622731
  • Sprute R, Seidel D, Cornely OA, Hoenigl M (2021). EHA Endorsement of the Global Guideline for the Diagnosis and Management of Rare Mold Infection: An Initiative of the European Confederation of Medical Mycology in Cooperation With International Society for Human and Animal Mycology and American Society for Microbiology. Hemasphere. 2021 Feb 23;5(3):e519. doi: 10.1097/HS9.0000000000000519. eCollection 2021 Mar. PMID: 33644696 No abstract available
  • Giesen N, Sprute R, Rüthrich M, Khodamoradi Y, Mellinghoff SC, Beutel G, Lueck C, Koldehoff M, Hentrich M, Sandherr M, von Bergwelt-Baildon M, Wolf HH, Hirsch HH, Wörmann B, Cornely OA, Köhler P, Schalk E, von Lilienfeld-Toal M; COVID-19 guideline panel of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) (2021). 2021 update of the AGIHO guideline on evidence-based management of COVID-19 in patients with cancer regarding diagnostics, viral shedding, vaccination and therapy. Eur J Cancer.2021 Feb 10;147:154-160. doi: 10.1016/j.ejca.2021.01.033. Online ahead of print. PMID: 33676266
  • Meinberger D, Koch M, Roth A, Hermes G, Stemler J, Cornely OA, Streichert T, Klatt AR. Analysis of IgM, IgA, and IgG isotype antibodies Directed against SARS-CoV-2 spike glycoprotein and ORF8 in the course of COVID-19. Sci Rep. 2021 Apr 26;11(1):8920. doi: 10.1038/s41598-021-88356-8. PMID: 33903660; PMCID: PMC8076237. 
  • Classen AY, Henze L, von Lilienfeld-Toal M, Maschmeyer G, Sandherr M, Graeff LD, Alakel N, Christopeit M, Krause SW, Mayer K, Neumann S, Cornely OA, Penack O, Weißinger F, Wolf HH, Vehreschild JJ (2021).Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors: 2020 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO/DGHO). Ann Hematol. 2021 Jun;100(6):1603-1620. doi: 10.1007/s00277-021-04452-9. Epub 2021 Apr 13. PMID: 33846857; PMCID: PMC8116237. 
  • Stemler J, Cornely OA, Noack-Schönborn T, Fohrholz C, Schumacher S, Poluschkin L, Binder B, Lehmann C, Langebartels G (2021). Web-based, rapid and contactless management of ambulatory patients for SARS-CoV-2-testing. BMC Infect Dis. 2021 Jun 7;21(1):535. doi: 10.1186/s12879-021-06249-7. PMID: 34098882; PMCID: PMC8182346.
  • Rudramurthy SM, Hoenigl M, Meis JF, Cornely OA, Muthu V, Gangneux JP, Perfect J, Chakrabarti A; ECMM and ISHAM (2021). ECMM/ISHAM recommendations for clinical management of COVID -19 associated mucormycosis in low- and middle-income countries. Mycoses.2021 Jun 16. doi: 10.1111/myc.13335. Epub ahead of print. PMID: 34133816. 
  • Verweij PE, Brüggemann RJM, Azoulay E, Bassetti M, Blot S, Buil JB, Calandra T, Chiller T, Clancy CJ, Cornely OA, Depuydt P, Koehler P, Lagrou K, de Lange D, Lass-Flörl C, Lewis RE, Lortholary O, Liu PL, Maertens J, Nguyen MH, Patterson TF, Rijnders BJA, Rodriguez A, Rogers TR, Schouten JA, Wauters J, van de Veerdonk FL, Martin-Loeches I (2021). Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis. Intensive Care Med. 2021 Jun 23:1–16. doi: 10.1007/s00134-021-06449-4. Epub ahead of print. PMID: 34160631; PMCID: PMC8220883. 
  • Koehler P, Bassetti M, Chakrabarti A, Chen SCA, Colombo AL, Hoenigl M, Klimko N, Lass-Flörl C, Oladele RO, Vinh DC, Zhu LP, Böll B, Brüggemann R, Gangneux JP, Perfect JR, Patterson TF, Persigehl T, Meis JF, Ostrosky-Zeichner L, White PL, Verweij PE, Cornely OA; European Confederation of Medical Mycology; International Society for Human Animal Mycology; Asia Fungal Working Group; INFOCUS LATAM/ISHAM Working Group; ISHAM Pan Africa Mycology Working Group; European Society for Clinical Microbiology; Infectious Diseases Fungal Infection Study Group; ESCMID Study Group for Infections in Critically Ill Patients; Interregional Association of Clinical Microbiology and Antimicrobial Chemotherapy; Medical Mycology Society of Nigeria; Medical Mycology Society of China Medicine Education Association; Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology; Association of Medical Microbiology; Infectious Disease Canada (2021). Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance. Lancet Infect Dis. 2021 Jun;21(6):e149-e162. doi: 10.1016/S1473-3099(20)30847-1. Epub 2020 Dec 14. PMID: 33333012; PMCID: PMC7833078. 
  • Groll AH, Gordon K, Buchheidt D, Willinger B, Heinz WJ, Kurzai O, Rickerts V, Cornely OA; Medical Mycology at German Academic Medical Centers (MMGAMC) Study Group (2021). State of Medical Mycology at German Academic Medical Centres: A Survey of the German-Speaking Mycological Society (DMYKG) and the Paul-Ehrlich-Society for Chemotherapy (PEG). Mycoses.2021 Jun 27. doi: 10.1111/myc.13346. Epub ahead of print. PMID: 34180098. 
  • Salmanton-García J, Busca A, Cornely OA, Corradini P, Hoenigl M, Klimko N, Marchesi F, Pagliuca A, Passamonti F, Koehler P, Pagano L (2021). EPICOVIDEHA: A Ready to Use Platform for Epidemiological Studies in Hematological Patients With COVID-19. Hemasphere. 2021 Jun 25;5(7):e612. doi: 10.1097/HS9.0000000000000612. PMID: 34235404; PMCID: PMC8232068.
  • Sprute R, Salmanton-García J, Sal E, Malaj X, Ráčil Z, Ruiz de Alegría Puig C, Falces-Romero I, Barać A, Desoubeaux G, Kindo AJ, Morris AJ, Pelletier R, Steinmann J, Thompson GR, Cornely OA, Seidel D, Stemler J; FungiScope® ECMM/ISHAM Working Group. Invasive infections with Purpureocillium lilacinum: clinical characteristics and outcome of 101 cases from FungiScope® and the literature. J Antimicrob Chemother.2021 May 12;76(6):1593-1603. doi: 10.1093/jac/dkab039. PMID: 33599275; PMCID: PMC8120338. 
  • Stern A, Alonso CD, Garcia-Vidal C, Cardozo C, Slavin M, Yong MK, Ho SA, Mehta Steinke S, Avery RK, Koehler P, Scheid C, Cornely OA, Maertens J, Abi Aad Y, Epstein DJ, Papanicolaou GA, Neofytos D. Safety and efficacy of intravenously administered cidofovir in adult haematopoietic cell transplant recipients: a retrospective multicentre cohort study. J Antimicrob Chemother.2021 Jul 29:dkab259. doi: 10.1093/jac/dkab259. Epub ahead of print. PMID: 34324678. 
  • Sprute R, Schumacher S, Pauls M, Pauls W, Cornely OA (2021). Delayed Cutaneous Hypersensitivity Reaction to Vaxzevria (ChAdOx1-S) Vaccine against SARS-CoV-2. Drugs R D. 2021 Aug 5:1–4. doi: 10.1007/s40268-021-00358-z. Epub ahead of print. PMID: 34351606; PMCID: PMC8339386. 
  • Jakob CEM, Classen AY, Stecher M, Engert A, Freund M, Hamprecht A, Jazmati N, Wisplinghoff H, Hallek M, Cornely OA, Vehreschild JJ (2021). Association between the dietary regimen and infection-related complications in neutropenic high-risk patients with cancer. Eur J Cancer.2021 Aug 13;155:281-290. doi: 10.1016/j.ejca.2021.06.054. Epub ahead of print. PMID: 34399112. 
  • Rudramurthy SM, Hoenigl M, Meis JF, Cornely OA, Muthu V, Gangneux JP, Perfect J, Chakrabarti A; ECMM and ISHAM (2021). ECMM/ISHAM recommendations for clinical management of COVID-19 associated mucormycosis in low- and middle-income countries. Mycoses. 2021 Sep;64(9):1028-1037. doi: 10.1111/myc.13335. Epub 2021 Jul 26. PMID: 34133816. 
  • Theobald SJ, Simonis A, Georgomanolis T, Kreer C, Zehner M, Eisfeld HS, Albert MC, Chhen J, Motameny S, Erger F, Fischer J, Malin JJ, Gräb J, Winter S, Pouikli A, David F, Böll B, Koehler P, Vanshylla K, Gruell H, Suárez I, Hallek M, Fätkenheuer G, Jung N, Cornely OA, Lehmann C, Tessarz P, Altmüller J, Nürnberg P, Kashkar H, Klein F, Koch M, Rybniker J (2021). Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med. 2021 Aug 9;13(8):e14150. doi: 10.15252/emmm.202114150. Epub 2021 Jun 16. PMID: 34133077; PMCID: PMC8350892. 
  • Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA (2021). Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology.Lancet Infect Dis.2021 Aug;21(8):e246-e257. doi: 10.1016/S1473-3099(20)30784-2. Epub 2021 Feb 16. Erratum in: Lancet Infect Dis. 2021 Apr;21(4):e81. PMID: 33606997. 
  • Joachim A, Dewald F, Suárez I, Zemlin M, Lang I, Stutz R, Marthaler A, Bosse HM, Lübke N, Münch J, Bernard MA, Jeltsch K, Tönshoff B, Weidner N, Kräusslich HG, Birzele L, Hübner J, Schmied P, Meyer-Bühn M, Horemheb-Rubio G, Cornely OA, Haverkamp H, Wiesmüller G, Fätkenheuer G, Hero B, Kaiser R, Dötsch J, Rybniker J; B-FAST study group (2021). Pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools - a cluster randomised trial. EClinicalMedicine.2021 Sep; 39:101082. doi: 10.1016/j.eclinm.2021.101082. Epub 2021 Aug 25. PMID: 34458708 
  • Wingen-Heimann SM, Cornely OA, J G T Vehreschild M, Wisplinghoff H, Franke B, Schons M, von Bergwelt-Baildon M, Scheid C, Vehreschild JJ (2021). Clinical and pharmacoeconomic evaluation of antifungal prophylaxis with continuous micafungin in patients undergoing allogeneic stem cell transplantation: A six-year cohort analysis. Mycoses. 2021 Apr;64(4):437-444. doi: 10.1111/myc.13232. Epub 2021 Jan 6. PMID: 33354800
  • Zhang J, Zhang Y, Wu D, Cao G, Hamed K, Desai A, Aram JA, Guo X, Fayyad R, Cornely OA (2021). Clinical experience with isavuconazole in healthy volunteers and patients with invasive aspergillosis in China, and the results from an exposure-response analysis. Mycoses. 2021 Apr;64(4):445-456. doi: 10.1111/myc.13233. Epub 2021 Jan 31.PMID: 33355949 
  • Prattes J, Koehler P, Hoenigl M; ECMM-CAPA Study Group (2021). COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges. Intensive Care Med.2021 Sep 1:1-2. doi: 10.1007/s00134-021-06510-2. Online ahead of print. PMID: 34468820
  • Jakobs F, Wingen-Heimann SM, Jeck J, Kron A, Cornely OA, Kron F (2021). A budget impact analysis of bezlotoxumab versus standard of care antibiotics only in patients at high risk of CDI recurrence from a hospital management perspective in Germany. BMC Health Serv Res.2021 Sep 9;21(1):939. doi: 10.1186/s12913-021-06970-8. PMID: 34496836
  • Steenwyk JL, Mead ME, de Castro PA, Valero C, Damasio A, Dos Santos RAC, Labella AL, Li Y, Knowles SL, Raja HA, Oberlies NH, Zhou X, Cornely OA, Fuchs F, Koehler P, Goldman GH, Rokas A (2021). Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus. Microbiol Spectr.2021 Sep 3;9(1):e0001021. doi: 10.1128/Spectrum.00010-21. Epub 2021 Jun 9. PMID: 34106569
  • Hoenigl M, Sprute R, Egger M, Arastehfar A, Cornely OA, Krause R, Lass-Flörl C, Prattes J, Spec A, Thompson GR 3rd, Wiederhold N, Jenks JD (2021). The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin. Drugs. 2021 Oct 9:1-27. doi: 10.1007/s40265-021-01611-0. Online ahead of print. PMID: 34626339 
  • Giacobbe DR, Magnasco L, Sepulcri C, Mikulska M, Koehler P, Cornely OA, Bassetti M (2021). Recent advances and future perspectives in the pharmacological treatment of Candida auris infections. Expert Rev Clin Pharmacol.2021 Oct;14(10):1205-1220. doi:10.1080/17512433.2021.1949285. Epub 2021 Jul 15. PMID: 34176393
  • Pagano L, Salmanton-García J, Marchesi F, Busca A, Corradini P, Hoenigl M, Klimko N, Koehler P, Pagliuca A, Passamonti F, Verga L, Víšek B, Ilhan O, Nadali G, Weinbergerová B, Córdoba-Mascuñano R, Marchetti M, Collins GP, Farina F, Cattaneo C, Cabirta A, Gomes-Silva M, Itri F, van Doesum J, Ledoux MP, Čerňan M, Jakšić O, Duarte RF, Magliano G, Omrani AS, Fracchiolla NS, Kulasekararaj A, Valković T, Poulsen CB, Machado M, Glenthøj A, Stoma I, Ráčil Z, Piukovics K, Navrátil M, Emarah Z, Sili U, Maertens J, Blennow O, Bergantim R, García-Vidal C, Prezioso L, Guidetti A, Del Principe MI, Popova M, de Jonge N, Ormazabal-Vélez I, Fernández N, Falces-Romero I, Cuccaro A, Meers S, Buquicchio C, Antić D, Al-Khabori M, García-Sanz R, Biernat MM, Tisi MC, Sal E, Rahimli L, Čolović N, Schönlein M, Calbacho M, Tascini C, Miranda-Castillo C, Khanna N, Méndez GA, Petzer V, Novák J, Besson C, Duléry R, Lamure S, Nucci M, Zambrotta G, Žák P, Seval GC, Bonuomo V, Mayer J, López-García A, Sacchi MV, Booth S, Ciceri F, Oberti M, Salvini M, Izuzquiza M, Nunes-Rodrigues R, Ammatuna E, Obr A, Herbrecht R, Núñez-Martín-Buitrago L, Mancini V, Shwaylia H, Sciumè M, Essame J, Nygaard M, Batinić J, Gonzaga Y, Regalado-Artamendi I, Karlsson LK, Shapetska M, Hanakova M, El-Ashwah S, Borbényi Z, Çolak GM, Nordlander A, Dragonetti G, Maraglino AME, Rinaldi A, De Ramón-Sánchez C, Cornely OA; EPICOVIDEHA working group (2021). COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). J Hematol Oncol. 2021 Oct 14;14(1):168. doi: 10.1186/s13045-021-01177-0. PMID: 34649563
  • Podda M, Kovacs M, Hellmich M, Roth R, Zarrouk M, Kraus D, Prinz-Langenohl R, Cornely OA (2021). A randomised controlled multicentre investigator-blinded clinical trial comparing efficacy and safety of surgery versus complex physical decongestive therapy for lipedema (LIPLEG).Trials. 2021 Oct 30;22(1):758. doi: 10.1186/s13063-021-05727-2. PMID: 34717741 
  • Koehler FC, Blomberg L, Brehm TT, Büttner S, Cornely OA, Degen O, Di Cristanziano V, Dolff S, Eberwein L, Hoxha E, Hoyer-Allo KJR, Rudolf S, Späth MR, Wanken M, Müller RU, Burst V (2021). Development and design of the Hantavirus registry - HantaReg - for epidemiological studies, outbreaks and clinical studies on hantavirus disease. Clin Kidney J.2021 Mar 5;14(11):2365-2370. doi: 10.1093/ckj/sfab053. eCollection 2021 Nov. PMID: 34754431 
  • Busca A, Salmanton-García J, Corradini P, Marchesi F, Cabirta A, Di Blasi R, Dulery R, Lamure S, Farina F, Weinbergerová B, Batinić J, Nordlander A, Lopez-Garcia A, Drgona L, Espigado I, Falces-Romero I, Garcia-Sanz R, Garcia-Vidal C, Guidetti A, Khanna N, Kulesekararaj A, Maertens J, Hoenigl M, Klimko N, Koehler P, Pagliuca A, Passamonti F, Cornely O, Pagano L. COVID-19 and CAR-T cells: current challenges and future directions-a report from the EPICOVIDEHA survey by EHA-IDWP. Blood Adv. 2021 Nov 8:bloodadvances.2021005616. doi: 10.1182/bloodadvances.2021005616. Online ahead of print. PMID: 34749396 
  • Cornely OA, Gow N, Hoenigl M, Warris A (2021). 10th Trends in Medical Mycology Held on 8 to 11 October 2021, Aberdeen, Scotland, Organized by the European Confederation of Medical Mycology (ECMM). J Fungi (Basel). 2021 Oct 28;7(11):916. doi: 10.3390/jof7110916. PMID: 34829205
  • Brockhoff RA, Hicks SR, Salmanton-García J, Dušek D, Stahl JP, Beeching NJ, Cornely OA(2021). Training in infectious diseases across Europe in 2021 - a survey on training delivery, content and assessment. Clin Microbiol Infect. 2021 Nov;27(11):1693.e1-1693.e8. doi: 10.1016/j.cmi.2021.07.033. Epub 2021 Aug 8. PMID: 34371206.
  • Mellinghoff SC, Thelen M, Bruns C, Garcia-Marquez M, Hartmann P, Lammertz T, Lehmann J, Nowag A, Stemler J, Wennhold K, Cornely OA, von Bergwelt-Baildon MS, Schlößer HA(2021). T-cells of invasive candidiasis patients show patterns of T-cell-exhaustion suggesting checkpoint blockade as treatment option. J Infect. 2021 Dec 15:S0163-4453(21)00606-X. doi: 10.1016/j.jinf.2021.12.009. Epub ahead of print. PMID: 34921845.
  • Sprute R, Cornely OA, Chen SC, Seidel D, Schuetz AN, Zhang SX(2021). All You Need To Know and More about the Diagnosis and Management of Rare Yeast Infections. mBio.2021 Aug 31;12(4):e0159421. doi: 10.1128/mBio.01594-21. Epub 2021 Aug 24. PMID: 34425700; PMCID: PMC8406212.
  • Berkell, M., Mysara, M., Xavier, B.B., van Werkhoven, C.H., Monsieurs, P., Lammens, C., Ducher, A., Vehreschild, M.J.G.T., Goossens, H., de Gunzburg, J., Bonten, M.J.M., Malhotra-Kumar, S., Engbers, A., de Regt, M., Biehl, L.M., Cornely, O.A., Jazmati, N., Bouverne, M.N., Sablier-Gallis, F., Mentre, F., Merle, U., Stallmach, A., Rupp, J., Bogner, J., Lubbert, C., Silling, G., Witzke, O., Gikas, A., Maraki, S., Daikos, G., Tsiodras, S., Skoutelis, A., Sambatakou, H., Pujol, M., Dominguez-Luzon, M.A., Aguado, J.M., Bouza, E., Cobo, J., Rodriguez-Bano, J., Almirante, B., Cisneros, J.D., Florescu, S.A., Nica, M., Vata, A., Hristea, A., Lupse, M., Herghea, D., Postil, D., Barraud, O., Molina, J.M., De Lastours, V., Guimard, T., Talarmin, J.P., Duval, X., Bernard, L., Launay, O., and Grp, A.S. (2021). Microbiota-based markers predictive of development of infection. Nat Commun 12. ARTN 2241.10.1038/s41467-021-22302-0.
  • Chen, S.C.A., Perfect, J., Colombo, A.L., Cornely, O.A., Groll, A.H., Seidel, D., Albus, K., de Almedia, J.N., Garcia-Effron, G., Gilroy, N., Lass-Flörl, C., Ostrosky-Zeichner, L., Pagano, L., Papp, T., Rautemaa-Richardson, R., Salmanton-García, J., Spec, A., Steinmann, J., Arikan-Akdagli, S., Arenz, D.E., Sprute, R., Duran-Graeff, L., Freiberger, T., Girmenia, C., Harris, M., Kanj, S.S., Roudbary, M., Lortholary, O., Meletiadis, J., Segal, E., Tuon, F.F., Wiederhold, N., Bicanic, T., Chander, J., Chen, Y.C., Hsueh, P.R., Ip, M., Munoz, P., Spriet, I., Temfack, E., Thompson, L., Tortorano, A.M., Velegraki, A., and Govender, N.P. (2021). Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis21, E375-E386. 10.1016/S1473-3099(21)00203-6.
  • Cornely, M.E., and Hettenhausen, C. (2021). The Addition of Hyaluronidase to Tumescent Local Anesthesia Supports Lymphological Liposculpture of Secondary Lymphedema. Prs-Glob Open9. ARTN e3995. 10.1097/GOX.0000000000003995.
  • Cornely, O.A., File, T.M., Jr., Garrity-Ryan, L., Chitra, S., Noble, R., and McGovern, P.C. (2021). Safety and efficacy of omadacycline for treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections in patients with mild-to-moderate renal impairment. Int J Antimicrob Agents57, 106263. 10.1016/j.ijantimicag.2020.106263.
  • Del Principe, M.I., Criscuolo, M., Seidel, D., Dargenio, M., Racil, Z., Piedimonte, M., Marchesi, F., Nadali, G., Koehler, P., Fracchiolla, N., Cattaneo, C., Klimko, N., Spolzino, A., Karapinar, D.Y., Demiraslan, H., Duarte, R., Demeter, J., Stanziani, M., Melillo, L., Basilico, C.M., Cesaro, S., Paterno, G., Cornely, O.A., Califano, C., Delia, M., Busca, A., Pagano, L., and Epidemiologica, S. (2021). Clinical Characteristics and Outcome of Invasive Infections Due to Saprochaete Species in Patients Affected by Hematological Malignancies. A Multi-Center Study on Behalf of Seifem/Fungiscope Registry. Haematologica106, 120-120.
  • Jeck, J., Wingen-Heimann, S.M., Thielscher, C., Kron, A., Bonn, J., Jakobs, F., Grau, S., Enoch, D.A., Micallef, C., Cornely, O.A., and Kron, F. (2021). Reimbursement of innovative pharmaceuticals in English and Spanish hospitals-The example of isavuconazole. Mycoses64, 1213-1222. 10.1111/myc.13336.
  • Koehler, P., White, P.L., Verweij, P.E., and Cornely, O.A. (2021). Diagnostic dilemma in COVID-19-associated pulmonary aspergillosis reply. Lancet Infect Dis21, 767-769.
  • Marchesi, F., Salmanton-García, J., Lopez-Garcia, A., Dragonetti, G., Sili, U., Glenthoej, A., Buquicchio, C., Mikulska, M., Weinbergerova, B., Busca, A., Corradini, P., Hoenigl, M., Klimko, N.N., Pagliuca, A., Passamonti, F., Köhler, P., Cornely, O., and Pagano, L. (2021). COVID-19 Infection in Vaccinated Adult Patients with Hematological Malignancies. Preliminary Results from Epicovideha (Epidemiology of COVID-19 infection in patients with hematological malignancies: A European Haematology Association Survey). Blood138, 3733-+. 10.1182/blood-2021-147295.
  • Mellinghoff, S.C., Vanshylla, K., Dahlke, C., Addo, M.M., Cornely, O.A., Klein, F., Persigehl, T., Rybniker, J., Gruell, H., and Bröckelmann, P.J. (2021). Case Report: Clinical Management of a Patient With Metastatic Non-Small Cell Lung Cancer Newly Receiving Immune Checkpoint Inhibition During Symptomatic COVID-19. Frontiers in Immunology12. ARTN 798276. 10.3389/fimmu.2021.798276.
  • Papon, N., Nevez, G., Le Gal, S., Vigneau, C., Robert-Gangneux, F., Bouchara, J.P., Cornely, O.A., Denning, D.W., and Gangneux, J.P. (2021). Fungal infections in transplant recipients: pros and cons of immunosuppressive and antimicrobial treatment Comment. Lancet Microbe2, E6-E8.
  • Salmanton-García, J., Busca, A., Cornely, O.A., Corradini, P., Hoenigl, M., Klimko, N., Marchesi, F., Pagliuca, A., Passamonti, F., Koehler, P., and Pagano, L. (2021). EPICOVIDEHA: A Ready to Use Platform for Epidemiological Studies in Hematological Patients With COVID-19. Hemasphere5. ARTN e612. 10.1097/HS9.0000000000000612.
  • Schumacher, S., Salmanton-Garcia, J., Cornely, O.A., and Mellinghoff, S.C. (2021). Increasing influenza vaccination coverage in healthcare workers: a review on campaign strategies and their effect. Infection49, 387-399. 10.1007/s15010-020-01555-9.
  • Stemler, J., Skoetz, N., de Jonge, N., Bruggemann, R., Sinkó, J., Busca, A., Ben Ami, R., Rácil, Z., Piechotta, V., Lewis, R., and Cornely, O.A. (2021). EHA guideline: antifungal prophylaxis in acute myeloid leukemia treated with novel agents. Mycoses64, 3-4.
  • Tenbusch, M., Schumacher, S., Vogel, E., Priller, A., Held, J., Steininger, P., Beileke, S., Irrgang, P., Brockhoff, R., Salmanton-García, J., Tinnefeld, K., Mijocevic, H., Schober, K., Bogdan, C., Yazici, S., Knolle, P., Cornely, O.A., Überla, K., Protzer, U., and tea, D.-V.-C.s. (2021). Heterologous prime-boost vaccination with ChAdOx1 nCoV-19 and BNT162b2. Lancet Infect Dis21, 1212-1213. 10.1016/S1473-3099(21)00420-5.
  • Thompson, G.R., Le, T., Chindamporn, A., Kauffman, C.A., Alastruey-Izquierdo, A., Ampel, N.M., Andes, D.R., Armstrong-James, D., Ayanlowo, O., Baddley, J.W., Barker, B.M., Bezerra, L.L., Buitrago, M.J., Chamani-Tabriz, L., Chan, J.F.W., Chayakulkeeree, M., Cornely, O.A., Cunwei, C., Gangneux, J.P., Govender, N.P., Hagen, F., Hedayati, M.T., Hohl, T.M., Jouvion, G., Kenyon, C., Kibbler, C.C., Klimko, N., Kong, D.C.M., Krause, R., Lee, L.L., Meintjes, G., Miceli, M.H., Rath, P.M., Spec, A., Queiroz-Telles, F., Variava, E., Verweij, P.E., Schwartz, I.S., and Pasqualotto, A.C. (2021). Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. Lancet Infect Dis21, E364-E374. 10.1016/S1473-3099(21)00191-2.
  • Vehreschild, M., van Werkhoven, C.H., Biehl, L., Dane, A., de Kraker, M.E., Mentré, F., Burdet, C., Glupczynski, G., Timbermont, L., Pfender, E., Sablier-Gallis, F., Andremont, A., de Gunzburg, J., Buffet, R., Wilcox, M., Cornely, O., Bonten, M., and Vitry, F. (2021). A Phase 3 Randomized Controlled Trial (MICROCARE) to Evaluate the Efficacy of DAV132 in Preventing Clostridioides Difficile Infection in Patients with Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome and Treated with Intensive Chemotherapy. Blood138. 10.1182/blood-2021-146501.

Mauro Corrado

  • Fabri M, Villa M, Stanczak MA, Edwards-Hicks J, Corrado M, Pearce EL (2021). Research Techniques Made Simple: Profiling Cellular Energy Metabolism. J Invest Dermatol. 2021 Dec;141(12):2767-2774.e2. doi: 10.1016/j.jid.2021.09.004. PMID: 3480254
  • Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kamiński MM, Stanckzak M, Weiss HJ, Grzes KM, Piletic K, Field CS, Corrado M, Haessler F, Wang C, Musa Y, Schimmelpfennig L, Flachsmann L, Mittler G, Yosef N, Kuchroo VK, Buescher JM, Balabanov S, Pearce EJ, Green DR, Pearce EL (2021). Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell. 2021 Aug 5;184(16):4186-4202.e20. doi: 10.1016/j.cell.2021.06.007. Epub 2021 Jul 2. PMID: 34216540; PMCID: PMC8358979.
  • O'Sullivan D, Stanczak MA, Villa M, Uhl FM, Corrado M, Klein Geltink RI, Sanin DE, Apostolova P, Rana N, Edwards-Hicks J, Grzes KM, Kabat AM, Kyle RL, Fabri M, Curtis JD, Buck MD, Patterson AE, Regina A, Field CS, Baixauli F, Puleston DJ, Pearce EJ, Zeiser R, Pearce EL(2021).  Fever supports CD8+ effector T cell responses by promoting mitochondrial translation. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2023752118. doi: 10.1073/pnas.2023752118. Epub 2021 Jun 14. PMID: 34161266; PMCID: PMC8237659.
  • Quintana-Cabrera R, Manjarrés-Raza I, Vicente-Gutiérrez C, Corrado M, Bolaños JP, Scorrano L(2021). Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria. Redox Biol. 2021 May;41:101944. doi: 10.1016/j.redox.2021.101944. Epub 2021 Mar 19. PMID: 33780775; PMCID: PMC8039725.
  • Corrado M, Samardžić D, Giacomello M, Rana N, Pearce EL, Scorrano L(2021). Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism. Cell Death Differ. 2021 Jul;28(7):2194-2206. doi: 10.1038/s41418-021-00747-6. Epub 2021 Mar 1. PMID: 33649469; PMCID: PMC8257785.

Joris Deelen

  • Deelen J (2021). Targeting multimorbidity: Using healthspan and lifespan to identify biomarkers of ageing that pinpoint shared disease mechanisms. EBioMedicine. 2021 May;67:103364. doi: 10.1016/j.ebiom.2021.103364. Epub 2021 May 6. PMID: 33965870; PMCID: PMC8114127.
  • H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circ-Genom Precis Me13, 541-547. ARTN e002610. 10.1161/CIRCGEN.119.002610.
  • Ahluwalia, T.S., Prins, B.P., Abdollahi, M., Armstrong, N.J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-Shlomo, Y., Bis, J.C., Mitchell, B.D., de Geus, E., Delgado, G.E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J.P., Lu, C., Marioni, R.E., McLachlan, S., Milaneschi, Y., Nolte, I.M., Petrelis, A.M., Porcu, E., Sabater-Lleal, M., Naderi, E., Seppala, I., Shah, T., Singhal, G., Standl, M., Teumer, A., Thalamuthu, A., Thiering, E., Trompet, S., Ballantyne, C.M., Benjamin, E.J., Casas, J.P., Toben, C., Dedoussis, G., Deelen, J., Durda, P., Engmann, J., Feitosa, M.F., Grallert, H., Hammarstedt, A., Harris, S.E., Homuth, G., Hottenga, J.J., Jalkanen, S., Jamshidi, Y., Jawahar, M.C., Jess, T., Kivimaki, M., Kleber, M.E., Lahti, J., Liu, Y., Marques-Vidal, P., Mellstrom, D., Mooijaart, S.P., Muller-Nurasyid, M., Penninx, B., Revez, J.A., Rossing, P., Raikkonen, K., Sattar, N., Scharnagl, H., Sennblad, B., Silveira, A., Pourcain, B.S., Timpson, N.J., Trollor, J., Group, C.I.W., van Dongen, J., Van Heemst, D., Visvikis-Siest, S., Vollenweider, P., Volker, U., Waldenberger, M., Willemsen, G., Zabaneh, D., Morris, R.W., Arnett, D.K., Baune, B.T., Boomsma, D.I., Chang, Y.C., Deary, I.J., Deloukas, P., Eriksson, J.G., Evans, D.M., Ferreira, M.A., Gaunt, T., Gudnason, V., Hamsten, A., Heinrich, J., Hingorani, A., Humphries, S.E., Jukema, J.W., Koenig, W., Kumari, M., Kutalik, Z., Lawlor, D.A., Lehtimaki, T., Marz, W., Mather, K.A., Naitza, S., Nauck, M., Ohlsson, C., Price, J.F., Raitakari, O., Rice, K., Sachdev, P.S., Slagboom, E., Sorensen, T.I.A., Spector, T., Stacey, D., Stathopoulou, M.G., Tanaka, T., Wannamethee, S.G., Whincup, P., Rotter, J.I., Dehghan, A., Boerwinkle, E., Psaty, B.M., Snieder, H., and Alizadeh, B.Z. (2021). Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Hum Mol Genet30, 393-409. 10.1093/hmg/ddab023.
  • Deelen, J., Evans, D.S., Arking, D.E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M.K., Biggs, M.L., van der Spek, A., Atzmon, G., Ware, E.B., Sarnowski, C., Smith, A.V., Seppala, I., Cordell, H.J., Dose, J., Amin, N., Arnold, A.M., Ayers, K.L., Barzilai, N., Becker, E.J., Beekman, M., Blanche, H., Christensen, K., Christiansen, L., Collerton, J.C., Cubaynes, S., Cummings, S.R., Davies, K., Debrabant, B., Deleuze, J.F., Duncan, R., Faul, J.D., Franceschi, C., Galan, P., Gudnason, V., Harris, T.B., Huisman, M., Hurme, M.A., Jagger, C., Jansen, I., Jylha, M., Kahonen, M., Karasik, D., Kardia, S.L.R., Kingston, A., Kirkwood, T.B.L., Launer, L.J., Lehtimaki, T., Lieb, W., Lyytikainen, L.P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A.B., Nie, C., Nohr, E.A., Orwoll, E.S., Perls, T.T., Province, M.A., Psaty, B.M., Raitakari, O.T., Reinders, M.J.T., Robine, J.M., Rotter, J.I., Sebastiani, P., Smith, J., Sorensen, T.I.A., Taylor, K.D., Uitterlinden, A.G., van der Flier, W., van der Lee, S.J., van Duijn, C.M., van Heemst, D., Vaupel, J.W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D.P., Lunetta, K.L., Slagboom, P.E., and Murabito, J.M. (2021). Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun12, 2463. 10.1038/s41467-021-22613-2.
  • Timmers, P., Tiys, E., Sakaue, S., Akiyama, M., Kiiskinen, T., Zhou, W., Hwang, S.J., Yao, C., Deelen, J., Levy, D., Ganna, A., Kamatani, Y., Okada, Y., Joshi, P., Wilson, J.F., and Tsepilov, Y. (2021). Genetically independent Phenotype Analysis Identifies LPA and VCAM1 as Drug Targets for Human Ageing. Hum Hered85, 95-95.

 

Constantinos Demetriades

  • Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, Genomics England Research Consortium, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K (2021). G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell. 2021 Jan 18:S0092-8674(20)31694-9. doi: 10.1016/j.cell.2020.12.024. Online ahead of print. PMID: 33497611
  • Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D. TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol Cell. 2021 Apr 30:S1097-2765(21)00324-5. doi: 10.1016/j.molcel.2021.04.019. Epub ahead of print. PMID: 33974911. 
  • Nüchel J, Tauber M, Nolte JL, Mörgelin M, Türk C, Eckes B, Demetriades C, Plomann M (2021). An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Mol Cell.2021 Jul 5:S1097-2765(21)00497-4. doi: 10.1016/j.molcel.2021.06.017. Epub ahead of print. PMID: 34245671.
  • Demetriades C,Nuüchel J, Plomann M (2021). GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome. Cell Stress. 2021 Oct 15;5(11):173-175. doi: 10.15698/cst2021.11.259. eCollection 2021 Nov. PMID: 34782889 
  • Fernandes SA, Demetriades C. The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging. Front Aging. 2021 Aug 27;2:707372. doi: 10.3389/fragi.2021.707372. PMID: 35822019; PMCID: PMC9261424.
  • Cheret, J., Suzuki, T., Scala, F., O'Sullivan, J., Nicu, C., Gherardini, J., Epstein-Kuka, G., Bauman, A., Demetriades, C., and Paus, R. (2021). mTORC1 activity controls human scalp hair follicle pigmentation and growth. J Invest Dermatol141, S104-S104.

Martin Denzel

  • Schiffer I, Gerisch B, Kawamura K, Laboy R, Hewitt J, Denzel MS, Mori MA, Vanapalli S, Shen Y, Symmons O, Antebi A (2021). miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging. Elife. 2021 Jul 27;10:e66768. doi: 10.7554/eLife.66768. PMID: 34311841; PMCID: PMC8315803.
  • Allmeroth K, Horn M, Kroef V, Miethe S, Müller RU, Denzel MS (2021). Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma. Leukemia.2021 Mar;35(3):887-892. doi: 10.1038/s41375-020-0989-4. Epub 2020 Jul 20. PMID: 32690882 
  • Allmeroth K, Kim CS, Annibal A, Pouikli A, Koester J, Derisbourg MJ, Andrés Chacón-Martínez C, Latza C, Antebi A,Tessarz P, Wickström SA, Denzel MS. N1-acetylspermidine is a determinant of hair follicle stem cell fate. J Cell Sci. 2021 May 1;134(9):jcs252767. doi: 10.1242/jcs.252767. Epub 2021 May 11. PMID: 33973637.
  • Derisbourg MJ, Wester LE, Baddi R, Denzel MS. Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation. Nat Commun. 2021 Mar 15;12(1):1678. doi: 10.1038/s41467-021-21743-x. PMID: 33723245; PMCID: PMC7960713.
  • Ruegenberg S, Mayr FAMC, Atanassov I, Baumann U, Denzel MS. Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1. Nat Commun. 2021 Apr 12;12(1):2176. doi: 10.1038/s41467-021-22320-y. PMID: 33846315.
  • Allmeroth K, Denzel MS (2021). The RATIOnal Role of Polyamines in Epidermal Differentiation. J Invest Dermatol. 2021 Sep;141(9):2105-2107. doi: 10.1016/j.jid.2021.02.011. PMID: 34420674
  • Guerrero GA, Derisbourg MJ, Mayr FA, Wester LE, Giorda M, Dinort JE, Hartman MD, Schilling K, Alonso-De Gennaro MJ, Lu RJ, Benayoun BA, Denzel MS (2021). NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants. Elife. 2021 Aug 27;10:e53174. doi: 10.7554/eLife.53174. PMID: 34448454
  • Derisbourg, M.J., Hartman, M.D. & Denzel, M.S(2021). Modulating the integrated stress response to slow aging and ameliorate age-related pathology. Nat Aging 1, 760–768 (2021). doi.org/10.1038/s43587-021-00112-9

Alexander Dilthey

  • Dilthey, A.T. (2021). State-of-the-art genome inference in the human MHC. Int J Biochem Cell B131. ARTN 105882. 10.1016/j.biocel.2020.105882.
  • Nodari, C.S., Fuchs, S.A., Xanthopoulou, K., Cayô, R., Seifert, H., Gales, A.C., Dilthey, A., and Higgins, P.G. (2021). pmrCAB Recombination Events among Colistin-Susceptible and -Resistant Acinetobacter baumannii Clinical Isolates Belonging to International Clone 7. Msphere6. ARTN e00746-21. 10.1128/msphere.00746-21.
  • Persa, O.D., Vorhagen, S., Goebel, U., Stinn, J., Dilthey, A., and Niessen, C. (2021). Epidermal aPKC polarity signaling suppresses field cancerization upon loss of p53. J Invest Dermatol141, S191-S191.
  • Ptok, J., Müller, L., Ostermann, P.N., Ritchie, A., Dilthey, A.T., Theiss, S., and Schaal, H. (2021). Modifying splice site usage with ModCon: Maintaining the genetic code while changing the underlying mRNP code. Comput Struct Biotec19, 3069-3076. 10.1016/j.csbj.2021.05.033.

Dominik Pesta

  • Strasser B, Pesta D, Rittweger J, Burtscher J, Burtscher M (2021). Nutrition for Older Athletes: Focus on Sex-Differences. Nutrients. 2021 Apr 22;13(5):1409. doi: 10.3390/nu13051409. PMID: 33922108; PMCID: PMC8143537.
  • Gratl A, Wipper S, Frese JP, Raude B, Greiner A, Pesta D. (2021). The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies. Int J Mol Sci. 2021 Aug 6;22(16):8478. doi: 10.3390/ijms22168478. PMID: 34445191
  • Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D,Calabria E (2021). Human Platelet Mitochondrial Function Reflects Systemic Mitochondrial Alterations: A Protocol for Application in Field Studies. Cells. 2021 Aug 14;10(8):2088. doi: 10.3390/cells10082088. PMID: 34440857

Sabine Eming

  • Ding X, Kakanj P, Leptin M, Eming SA (2021).. Regulation of the wound healing response during aging. J Invest Dermatol. 2021 Feb 5;S0022-202X(20)32360-5. doi: 10.1016/j.jid.2020.11.014. Online ahead of print 
  • Ding, X., Willenborg, S., Bloch, W., Brodesser, S., Roers, A., and Eming, S.A. (2021). Dysfunctional mTORC2 signalling as potential risk factor for inflammatory skin diseases. J Invest Dermatol 141, S166-S166.
  • Hadrian K, Willenborg S, Bock F, Cursiefen C, Eming SA, Hos D. Macrophage-Mediated Tissue Vascularization: Similarities and Differences Between Cornea and Skin. Front Immunol. 2021 Apr 7;12:667830. doi: 10.3389/fimmu.2021.667830. PMID: 33897716; PMCID: PMC8058454. 
  • Eming SA, Murray PJ, Pearce EJ (2021). Metabolic orchestration of the wound healing response. Cell Metab. 2021 Aug 9:S1550-4131(21)00362-4. doi: 10.1016/j.cmet.2021.07.017. Epub ahead of print. PMID: 34384520.
  • Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021 Oct 25:S1550-4131(21)00482-4. doi: 10.1016/j.cmet.2021.10.004. Online ahead of print. PMID: 34715039
  • Welcker, D., Stein, C., Feitosa, N.M., Armistead, J., Zhang, J.L., Lütke, S., Kleinridders, A., Brüning, J.C., Eming, S.A., Sengle, G., Niehoff, A., Bloch, W., and Hammerschmidt, M. (2021). Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions. Sci Rep-Uk 11. ARTN 17926. 10.1038/s41598-021-96824-4.
  • Willenborg, S., Sanin, D.E., Jais, A., Ding, X., Ulas, T., Nuchel, J., Popovic, M., MacVicar, T., Langer, T., Schultze, J.L., Gerbaulet, A., Roers, A., Pearce, E.J., Bruning, J.C., Trifunovic, A., and Eming, S.A. (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab 33, 2398-2414 e2399. 10.1016/j.cmet.2021.10.004.

Mafalda Escobar-Henriques 

  • Buntenbroich, I., Simões, T. Escobar-Henriques, M (2021). Analysis of Protein Stability by Synthesis Shutoff. Bio-protocol. 2021 Nov 20;11(22):e4225. doi:10.21769/BioProtoc.4225. PMID: 34909446
  • Klionsky, D.J., Abdel-Aziz, A.K., Abdelfatah, S., […] Escobar-Henriques, M., […] Brand-Saberi, B., Dong, X.C., Kenchappa, C.S., Li, Z., Lin, Y., Oshima, S., Rong, Y., Sluimer, J.C., Stallings, C.L., and Tong, C.K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy17, 1-382. 10.1080/15548627.2020.1797280.

Lukas P. Frenzel

  • Flümann R, Rehkämper T, Nieper P, Pfeiffer P, Holzem A, Klein S, Bhatia S, Kochanek M, Kisis I, Pelzer BW, Ahlert H, Hauer J, da Palma Guerreiro A, Ryan JA, Reimann M, Riabinska A, Wiederstein J, Krüger M, Deckert M, Altmüller J, Klatt AR, Frenzel LP, Pasqualucci L, Béguelin W, Melnick AM, Sander S, Montesinos-Rongen M, Brunn A, Lohneis P, Büttner R, Kashkar H, Borkhardt A, Letai A, Persigehl T, Peifer M, Schmitt CA, Reinhardt HC, Knittel G (2021). An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discov. 2021 Jan;2(1):70-91. doi: 10.1158/2643-3230.BCD-19-0059. PMID: 33447829 
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hövelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Büttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2021). Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood. 2021 Feb 4;137(5):646-660. doi: 10.1182/blood.2020005734. PMID: 33538798 
  • Neuendorff NR, Frenzel LP, Leuschner F, Fremd C (2021). Integrating clonal haematopoiesis into geriatric oncology: The ARCH between aging, cardiovascular disease and malignancy. J Geriatr Oncol. 2021 Apr;12(3):479-482. doi: 10.1016/j.jgo.2020.09.006. Epub 2020 Sep 23. PMID: 32978103.
  • Beckmann L, Berg V, Dickhut C, Sun C, Merkel O, Bloehdorn J, Robrecht S, Seifert M, da Palma Guerreiro A, Claasen J, Loroch S, Oliverio M, Underbayev C, Vaughn L, Thomalla D, Hülsemann MF, Tausch E, Fischer K, Fink AM, Eichhorst B, Sickmann A, Wendtner CM, Stilgenbauer S, Hallek M, Wiestner A, Zahedi RP, Frenzel LP (2021). MARCKS affects cell motility and response to BTK inhibitors in CLL. Blood. 2021 Aug 19;138(7):544-556. doi: 10.1182/blood.2020009165. PMID: 33735912; PMCID: PMC8377477. 
  • Frenzel LP (2021). PI3K/BCL2: illusion or promise for RS? Blood. 2021 Jun 17;137(24):3319-3321. doi: 10.1182/blood.2021011854. PMID: 34137851.
  • Richardson, T., Herling, M., Cruz-Aguilar, M.R., Frenzel, L.P., Hallek, M., Scheid, C., and Holtick, U. (2021). High-Dose Melphalan And Autologous Stem Cell Transplantation in Elderly Patients ≥ 70 Years is Safe And Effective - A Retrospective Analysis. Bone Marrow Transpl56, 286-286.

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Christian Frezza

  • Hajaj E, Sciacovelli M, Frezza C, Erez A (2021). The context-specific roles of urea cycle enzymes in tumorigenesis. Mol Cell Accepted for publication. 
  • Sant'Anna-Silva ACB, Perez-Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021). Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells. Cancers (Basel). 2021 Apr 6;13(7):1727. doi: 10.3390/cancers13071727. PMID: 33917317; PMCID: PMC8038717. 
  • Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel Á, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021). Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol. 2021 Apr 7;19(4):e3001166. doi: 10.1371/journal.pbio.3001166. PMID: 33826607; PMCID: PMC8055036. 
  • Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M (2021). Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021 Apr;23(4):413-423. doi: 10.1038/s41556-021-00637-6. Epub 2021 Apr 1. PMID: 33795871; PMCID: PMC8032556. 
  • Ryan DG, Frezza C, O'Neill LA (2021). TCA cycle signalling and the evolution of eukaryotes. Curr Opin Biotechnol. 2021 Apr;68:72-88. doi: 10.1016/j.copbio.2020.09.014. Epub 2020 Nov 1. PMID: 33137653; PMCID: PMC7116391. 
  • Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, Krieg T, Murphy MP, Aksentijević D (2021). Mechanism of succinate efflux upon reperfusion of the ischaemic heart. Cardiovasc Res. 2021 Mar 21;117(4):1188-1201. doi: 10.1093/cvr/cvaa148. PMID: 32766828; PMCID: PMC7983001. 
  • Dugourd A, Kuppe C, Sciacovelli M, Gjerga E, Gabor A, Emdal KB, Vieira V, Bekker-Jensen DB, Kranz J, Bindels EMJ, Costa ASH, Sousa A, Beltrao P, Rocha M, Olsen JV, Frezza C*, Kramann R*, Saez-Rodriguez J* (2021). Causal integration of multi- omics data with prior knowledge to generate mechanistic hypotheses. Mol Syst Biol. 2021 Jan;17(1):e9730. doi: 10.15252/msb.20209730. PMID: 33502086; PMCID: PMC7838823. *: co-senior author 
  • Romani P, Valcarcel-Jimenez L, Frezza C, Dupont S (2021). Crosstalk between mechanotransduction and metabolism. Nat Rev Mol Cell Biol. 2021 Jan;22(1):22-38. doi: 10.1038/s41580-020-00306-w. Epub 2020 Nov 13. PMID: 33188273.

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Henning Fenselau

  • Bozadjieva-Kramer N, Ross RA, Johnson DQ, Fenselau H, Haggerty DL, Atwood B, Lowell B, Flak JN (2021). The Role of Mediobasal Hypothalamic PACAP in the Control of Body Weight and Metabolism. Endocrinology. 2021 Jan 18:bqab012. doi: 10.1210/endocr/bqab012. Online ahead of print. PMID: 33460433.
  • Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC (2021). Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 May 17. doi: 10.1038/s41593-021-00854-0. Epub ahead of print. PMID: 34002087.
  • Borgmann D, Ciglieri E, Biglari N, Brandt C, Cremer AL, Backes H, Tittgemeyer M, Wunderlich FT, Brüning JC, Fenselau H (2021). Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab. 2021 May 21:S1550-4131(21)00219-9. doi: 10.1016/j.cmet.2021.05.002. Epub ahead of print. PMID: 34043943.
  • Borgmann D, Rigoux L, Kuzmanovic B, Edwin Thanarajah S, Münte TF, Fenselau H, Tittgemeyer M (2021). Technical Note: Modulation of fMRI brainstem responses by transcutaneous vagus nerve stimulation. Neuroimage. 2021 Sep 10; 244:118566. doi: 10.1016/j.neuroimage.2021.118566. Online ahead of print. PMID: 34509623

 

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Ana J. Garcia-Saez

  • Dadsena S, Jenner A, García-Sáez AJ (2021). Mitochondrial outer membrane permeabilization at the single molecule level. Cell Mol Life Sci. 2021 Feb 12. doi: 10.1007/s00018-021-03771-4. Online ahead of print. PMID: 33576840 Review
  • Ros U, Pedrera L, Garcia-Saez AJ (2021). Techniques for studying membrane pores. Curr Opin Struct Biol. 2021 May 1;69:108-116. doi: 10.1016/j.sbi.2021.03.012. Epub ahead of print. PMID: 33945958
  • Danial JSH, Shalaby R, Cosentino K, Mahmoud MM, Medhat F, Klenerman D, Garcia Saez AJ (2021). DeepSinse: deep learning based detection of single molecules. Bioinformatics. 2021 May 8:btab352. doi: 10.1093/bioinformatics/btab352. Online ahead of print. PMID: 33964131 
  • Peña-Blanco A, Haschka MD, Jenner A, Zuleger T, Proikas-Cezanne T,Villunger A, García-Sáez AJ (2021). Correction: Drp1 modulates mitochondrial stress responses to mitotic arrest. Cell Death Differ. 2021 Jul 23. doi: 10.1038/s41418-021-00831-x. Epub ahead of print. Erratum for: Cell Death Differ. 2020 Sep;27(9):2620-2634. PMID: 34302122. 
  • Dadsena S, King LE, García-Sáez AJ (2021). Apoptosis regulation at the mitochondria membrane level. Biochim Biophys Acta Biomembr. 2021 Jul 31:183716. doi: 10.1016/j.bbamem.2021.183716. Epub ahead of print. PMID: 34343535.
  • Flores-Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L, Szabo T, Hertlein V, Luo X, Villunger A, Frenzel LP, Kashkar H, Garcia-Saez AJ(2021). BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. EMBO J. 2021 Dec 21:e108690. doi: 10.15252/embj.2021108690. Epub ahead of print. PMID: 34931711.
  • Cosentino K, Hermann E, von Kügelgen N, Unsay JD, Ros U, García-Sáez AJ (2021). Force Mapping Study of Actinoporin Effect in Membranes Presenting Phase Domains. Toxins (Basel). 2021 Sep 18;13(9):669. doi: 10.3390/toxins13090669. PMID: 34564674; PMCID: PMC8473010.
  • Murad F, Garcia-Saez AJ (2021). Bcl-xL inhibits tBid and Bax via distinct mechanisms. Faraday Discuss.2021 Dec 24;232(0):86-102. doi: 10.1039/d0fd00045k. PMID: 34528939.
  • Dadsena, S., Zollo, C., and García-Sáez, A.J. (2021). Mechanisms of mitochondrial cell death. Biochem Soc T49, 663-674. 10.1042/Bst20200522.
  • Wang, X., Ros, U., Agrawal, D., Keller, E.C., Slotta-Huspenina, J., Dill, V., Shen, B., Shi, R., Herold, T., Belka, C., Misra, R., Bassermann, F., Garcia-Saez, A.J., and Jost, P.J. (2021). MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF. Cell Death Differ28, 3235-3250. 10.1038/s41418-021-00811-1.

Martin Graef

  • 15.       Klionsky, D.J., Abdel-Aziz, A.K., […], Graef, M., […], Brand-Saberi, B., Dong, X.C., Kenchappa, C.S., Li, Z., Lin, Y., Oshima, S., Rong, Y., Sluimer, J.C., Stallings, C.L., and Tong, C.K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy17, 1-382. 10.1080/15548627.2020.1797280.
  • Kochan, D.Z., Mawer, J.S.P., Massen, J., Tishinov, K., Parekh, S., Graef, M., Spang, A., and Tessarz, P. (2021). The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription. Journal of Cell Science134. ARTN jcs259051. 10.1242/jcs.259051.

Michael Hallek

  • Agathangelidis, A., Chatzidimitriou, A., Gemenetzi, K., Giudicelli, V., Karypidou, M., Plevova, K., Davis, Z., Yan, X.J., Jeromin, S., Schneider, C., Pedersen, L.B., Tschumper, R.C., Sutton, L.A., Baliakas, P., Scarfò, L., van Gastel, E.J., Armand, M., Tausch, E., Biderman, B., Baer, C., Bagnara, D., Navarro, A., de Septenville, A.L., Guido, V., Mitterbauer-Hohendanner, G., Dimovski, A., Brieghel, C., Lawless, S., Meggendorfer, M., Brazdilova, K., Ritgen, M., Facco, M., Tresoldi, C., Visentin, A., Patriarca, A., Catherwood, M., Bonello, L., Sudarikov, A., Vanura, K., Roumelioti, M., Francova, H.S., Moysiadis, T., Veronese, S., Giannopoulos, K., Mansouri, L., Karan-Djurasevic, T., Sandaltzopoulos, R., Bödör, C., Fais, F., Kater, A., Panovska, I., Rossi, D., Alshemmari, S., Panagiotidis, P., Costeas, P., Espinet, B., Antic, D., Foroni, L., Montillo, M., Trentin, L., Stavroyianni, N., Gaidano, G., di Celle, P.F., Niemann, C., Campo, E., Anagnostopoulos, A., Pott, C., Fischer, K., Hallek, M., Oscier, D., Stilgenbauer, S., Haferlach, C., Jelinek, D., Chiorazzi, N., Pospisilova, S., Lefranc, M.P., Kossida, S., Langerak, A.W., Belessi, C., Davi, F., Rosenquist, R., Ghia, P., Stamatopoulos, K., and CLL, E.E.R.I. (2021). Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL. Blood137, 1365-1376. 10.1182/blood.2020007039.
  • Al-Sawaf, O., Gentile, B., Devine, J., Zhang, C., Sail, K., Tandon, M., Fink, A.M., Kutsch, N., Wendtner, C.M., Eichhorst, B., Hallek, M., and Fischer, K. (2021). Health-related quality of life with fixed-duration venetoclax-obinutuzumab for previously untreated chronic lymphocytic leukemia: Results from the randomized, phase 3 CLL14 trial. Am J Hematol96, 1112-1119. 10.1002/ajh.26260.
  • Al-Sawaf, O., Zhang, C., Lu, T., Liao, M.Z., Panchal, A., Robrecht, S., Ching, T., Tandon, M., Fink, A.M., Tausch, E., Schneider, C., Ritgen, M., Böttcher, S., Kreuzer, K.A., Chyla, B., Miles, D., Wendtner, C.M., Eichhorst, B., Stilgenbauer, S., Jiang, Y.W., Hallek, M., and Fischer, K. (2021). Minimal Residual Disease Dynamics after Venetoclax-Obinutuzumab Treatment: Extended Off-Treatment Follow-up From the Randomized CLL14 Study. J Clin Oncol39, 4049-+. 10.1200/Jco.21.01181.
  • Arshad, U., Taubert, M., Seeger-Nukpezah, T., Ullah, S., Spindeldreier, K.C., Jaehde, U., Hallek, M., Fuhr, U., Vehreschild, J.J., and Jakob, C. (2021). Evaluation of body-surface-area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients. Bmc Cancer21. ARTN 719. 10.1186/s12885-021-08443-x.
  • Arshad, U., Taubert, M., Seeger-Nukpezah, T., Ullah, S., Spindeldreier, K.C., Jaehde, U., Hallek, M., Fuhr, U., Vehreschild, J.J., and Jakob, C. (2021). Evaluation of body surface area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients. Eur J Clin Pharmacol77, 13-13.
  • Augustin, M., Hallek, M., and Nitschmann, S. (2021). Development of vaccines for prevention of COVID-19: part 3. Internist62, 690-693. 10.1007/s00108-021-01058-1.
  • Augustin, M., Hallek, M., and Nitschmann, S. (2021). Antibody therapy in patients with COVID-19. Internist62, 572-576. 10.1007/s00108-021-01022-z.
  • Augustin, M., Hallek, M., and Nitschmann, S. (2021). Development of Vaccines for the Prevention of COVID-19-Part 2. Internist62, 337-340. 10.1007/s00108-021-00985-3.
  • Augustin, M., Hallek, M., and Nitschmann, S. (2021). Vaccine Development for Prevention of COVID-19. Internist62, 106-109. 10.1007/s00108-020-00937-3.
  • Augustin, M., Schommers, P., Stecher, M., Dewald, F., Gieselmann, L., Gruell, H., Horn, C., Vanshylla, K., Di Cristanziano, V., Osebold, L., Roventa, M., Riaz, T., Tschernoster, N., Altmueller, J., Rose, L., Salomon, S., Priesner, V., Luers, J.C., Albus, C., Rosenkranz, S., Gathof, B., Fätkenheuer, G., Hallek, M., Klein, F., Suárez, I., and Lehmann, C. (2021). Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg Health-Eu6. ARTN 100122. 10.1016/j.lanepe.2021.100122.
  • Bamidis, A.D., Koehler, P., di Cristanziano, V., Rasche, K., Demirel, B., Bacher, P., Hallek, M., Kochanek, M., Klein, F., Hofmann, S.C., Wesselmann, U., and Kofler, D.M. (2021). First manifestation of adult-onset Still's disease after COVID-19. Lancet Rheumatol3, E319-E321. 10.1016/S2665-9913(21)00072-2.
  • Beckmann, L., Berg, V., Dickhut, C., Sun, C., Merkel, O., Bloehdorn, J., Robrecht, S., Seifert, M., Guerreiro, A.D., Claasen, J., Loroch, S., Oliverio, M., Underbayev, C., Vaughn, L., Thomalla, D., Hülsemann, M.F., Tausch, E., Fischer, K., Fink, A.M., Eichhorst, B., Sickmann, A., Wendtner, C.M., Stilgenbauer, S., Hallek, M., Wiestner, A., Zahedi, R.P., and Frenzel, L.P. (2021). MARCKS affects cell motility and response to BTK inhibitors in CLL. Blood138, 544-556. 10.1182/blood.2020009165.
  • Bloehdorn, J., Braun, A., Taylor-Weiner, A., Jebaraj, B.M.C., Robrecht, S., Krzykalla, J., Pan, H., Giza, A., Akylzhanova, G., Holzmann, K., Scheffold, A., Johnston, H.E., Yeh, R.F., Klymenko, T., Tausch, E., Eichhorst, B., Bullinger, L., Fischer, K., Weisser, M., Robak, T., Schneider, C., Gribben, J., Dahal, L.N., Carter, M.J., Elemento, O., Landau, D.A., Neuberg, D.S., Cragg, M.S., Benner, A., Hallek, M., Wu, C.J., Döhner, H., Stilgenbauer, S., and Mertens, D. (2021). Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia. Nat Commun12. ARTN 5395. 10.1038/s41467-021-25403-y.
  • Borchmann, P., Plütschow, A., Kobe, C., Greil, R., Meissner, J., Topp, M.S., Ostermann, H., Dierlamm, J., Mohm, J., Thiemer, J., Sökler, M., Kerkhoff, A., Ahlborn, M., Halbsguth, T.V., Martin, S., Keller, U., Balabanov, S., Pabst, T., Vogelhuber, M., Hüttmann, A., Wilhelm, M., Zijlstra, J.M., Moccia, A., Kuhnert, G., Bröckelmann, P.J., von Tresckow, B., Fuchs, M., Klimm, B., Rosenwald, A., Eich, H., Baues, C., Marnitz, S., Hallek, M., Diehl, V., Dietlein, M., and Engert, A. (2021). PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17) : a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol22, 223-234.
  • Borrega, J.G., Heger, J.M., Köhler, P., Holtick, U., Hallek, M., Scheid, C., Kochanek, M., Böll, B., Shimabukuro-Vornhagen, A., and Eichenauer, D. (2021). Characteristics and outcomes of allogeneic stem cell transplant recipients admitted to the intensive care unit within 30 days from transplantation - A retrospective analysis from a German University Hospital. Med Klin-Intensivmed116, 69-69.
  • Cramer, P., Tausch, E., von Tresckow, J., Giza, A., Robrecht, S., Schneider, C., Fürstenau, M., Langerbeins, P., Al-Sawaf, O., Pelzer, B.W., Fink, A.M., Fischer, K., Wendtner, C.M., Eichhorst, B., Kneba, M., Stilgenbauer, S., and Hallek, M. (2021). Durable remissions following combined targeted therapy in patients with CLL harboring TP53 deletions and/or mutations. Blood138, 1805-1816. 10.1182/blood.2020010484.
  • Cramer, P., von Tresckow, J., Robrecht, S., Bahlo, J., Furstenau, M., Langerbeins, P., Pflug, N., Al-Sawaf, O., Heinz, W.J., Vehling-Kaiser, U., Dürig, J., Tausch, E., Hensel, M., Sasse, S., Fink, A.M., Fischer, K., Kreuzer, K.A., Böttcher, S., Ritgen, M., Kneba, M., Wendtner, C.M., Stilgenbauer, S., Eichhorst, B., and Hallek, M. (2021). Bendamustine followed by ofatumumab and ibrutinib in chronic lymphocytic leukemia: primary endpoint analysis of a multicenter, open-label, phase II trial (CLL2-BIO). Haematologica106, 543-554. 10.3324/haematol.2019.223693.
  • Davids, M.S., Fischer, K., Robrecht, S., Zhang, C., Ahn, I.E., Lurà, M.P., Sinai, W., Chyla, B., Sail, K., Pesko, J., Pai, M., Komlosi, V., Hallek, M., Brown, J.R., and Al-Sawaf, O. (2021). ReVenG: A Phase 2 Study of Venetoclax Plus Obinutuzumab Retreatment in Patients with Relapsed Chronic Lymphocytic Leukemia. Blood138. 10.1182/blood-2021-153033.
  • Di Cristanziano, V., Meyer-Schwickerath, C., Eberhardt, K.A., Rybniker, J., Heger, E., Knops, E., Hallek, M., Klein, F., Holtick, U., and Jung, N. (2021). Detection of SARS-CoV-2 viremia before onset of COVID-19 symptoms in an allo-transplanted patient with acute leukemia. Bone Marrow Transpl56, 716-719. 10.1038/s41409-020-01059-y.
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Marco Herling

  • Böttcher M, Bruns H, Völkl S, Lu J, Chartomatsidou E, Papakonstantinou N, Mentz K, Büttner-Herold M, Zenz T, Herling M, Huber W, Ghia P, Stamatopoulos K, Mackensen A, Mougiakakos D. Control of PD-L1 expression in CLL-cells by stromal triggering of the Notch-c-Myc-EZH2 oncogenic signaling axis. J Immunother Cancer. 2021 Apr;9(4):e001889. doi: 10.1136/jitc-2020-001889. PMID: 33931470. 
  • Wahnschaffe L, Herling M (2021). Hijacking the Pathway: Perspectives in the Treatment of Mature T-cell Leukemias. Hemasphere.2021 Jun 1;5(6):e573. doi: 10.1097/HS9.0000000000000573. PMID: 34095757; PMCID: PMC8171373.
  • Braun T, Dechow A, Friedrich G, Seifert M, Stachelscheid J, Herling M(2021). Advanced Pathogenetic Concepts in T-Cell Prolymphocytic Leukemia and Their Translational Impact. Front Oncol. 2021 Nov 19;11:775363. doi: 10.3389/fonc.2021.775363. PMID: 34869023; PMCID: PMC8639578.

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Jan Hoeijmakers

  • Birkisdóttir MB, Jaarsma D, Brandt RMC, Barnhoorn S, van Vliet N, Imholz S, van Oostrom CT, Nagarajah B, Portilla Fernández E, Roks AJM, Elgersma Y, van Steeg H, Ferreira JA, Pennings JLA, Hoeijmakers JHJ, Vermeij WP, Dollé MET (2021). Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice. Aging Cell. 2021 Jan 23:e13302. doi: 10.1111/acel.13302. Online ahead of print.PMID: 33484480
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  • Van't Sant LJ, White JJ, Hoeijmakers JHJ, Vermeij WP, Jaarsma D (2021). In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21;9(1):94. doi: 10.1186/s40478-021-01200-y. PMID: 34020718; PMCID: PMC8139001.
  • Vermeij WP, Hoeijmakers JHJ (2021). Base editor repairs mutation found in the premature-ageing syndrome progeria. Nature. 2021 Jan;589(7843):522-524. Doi: 10.1038/d41586-020-03573-x. PMID:33408358
  • Schumacher B, Pothof J, Vijg J, Hoeijmakers JHJ (2021). The central role of DNA damage in the ageing process. Nature. 2021 Apr;592(7856):695-703. doi: 10.1038/s41586-021-03307-7. Epub 2021 Apr 28. PMID: 33911272.
  • van den Boogaard WMC, van den Heuvel-Eibrink MM, Hoeijmakers JHJ, Vermeij WP Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging. Annu Rev Cancer Biol. 2021 Mar;5:161-179. doi: 10.1146/annurev-cancerbio-060820-090737. Epub 2020 Dec 2.PMID: 35474917
  • Van Den Boogaard, W., Smit, K., Brandt, R., Barnhoorn, S., Rijksen, Y., Komninos, D., Van Den Heuvel-Eibrink, M., Hoeijmakers, J., and Vermeij, W. (2021). Pre-Therapy Fasting Reduces Acute and Late-Life Cisplatin Toxicities. Pediatr Blood Cancer68, S353-S353.

Thorsten Hoppe    

  • Ottens F, Franz A, Hoppe T (2021). Build-UPS and break-downs: metabolism impacts on proteostasis and aging. Cell Death Differ. 2021 Jan 4. doi: 10.1038/s41418-020-00682-y. Online ahead of print. PMID: 33398091 Review 
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  • Finger F, Ottens F, Hoppe T (2021). The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis. MicroPubl Biol. 2021 Oct 14;2021:10.17912/micropub.biology.000457. doi: 10.17912/micropub.biology.000457. eCollection 2021.PMID: 34723149
  • Höhfeld J., Benzing T., Bloch, W. Fürst D.O., Gehlert S., Hesse M., Hoffmann B., Hoppe T., Huesgen P.F., Köhn M., Kolanus W., Merkel R., NIessen C.M., Pokrzywa W., Rinschen M.M., Wachten D., Warscheid B. (2021). Maintaining proteostasis under mechanical stress. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507.Epub 2021 Jul 26.
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Tamas Horvath      

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  • Jin S, Yoon NA, Liu ZW, Song JE, Horvath TL, Kim JD, Diano S (2021). Drp1 is required for AgRP neuronal activity and feeding. Elife. 2021 Mar 9;10:e64351. doi: 10.7554/eLife.64351. PMID: 33689681; PMCID: PMC7946429.
  • Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB (2021). Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. PLoS Biol. 2021 Mar 17;19(3):e3001143. doi: 10.1371/journal.pbio.3001143. PMID: 33730024; PMCID: PMC8007021.
  • Zhang Y, Varela L, Szigeti-Buck K, Williams A, Stoiljkovic M, Šestan-Peša M, Henao-Mejia J, D'Acunzo P, Levy E, Flavell RA, Horvath TL, Kaczmarek LK (2021). Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1. Nat Commun. 2021 Mar 19;12(1):1731. doi: 10.1038/s41467-021-22003-8. PMID: 33741962; PMCID: PMC7979925.
  • Varela L, Stutz B, Song JE, Kim JG, Liu ZW, Gao XB, Horvath TL (2021). Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice. J Clin Invest. 2021 May 17;131(10):e144239. doi: 10.1172/JCI144239. PMID: 33848272; PMCID: PMC8121506.
  • Datta D, Leslie SN, Wang M, Morozov YM, Yang S, Mentone S, Zeiss C, Duque A, Rakic P, Horvath TL, van Dyck CH, Nairn AC, Arnsten AFT (2021). Age-related calcium dysregulation linked with tau pathology and impaired cognition in non-human primates. Alzheimers Dement. 2021 Jun;17(6):920-932. doi: 10.1002/alz.12325. Epub 2021 Apr 7. PMID: 33829643; PMCID: PMC8195842.
  • Yasumoto Y, Stoiljkovic M, Kim JD, Sestan-Pesa M, Gao XB, Diano S, Horvath TL (2021). Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior. Mol Psychiatry. 2021 Jul;26(7):2740-2752. doi: 10.1038/s41380-021-01105-1. Epub 2021 Apr 20. PMID: 33879866; PMCID: PMC8056795.
  • Li N, Zhao S, Zhang Z, Zhu Y, Gliniak CM, Vishvanath L, An YA, Wang MY, Deng Y, Zhu Q, Shan B, Sherwood A, Onodera T, Oz OK, Gordillo R, Gupta RK, Liu M, Horvath TL, Dixit VD, Scherer PE (2021). Adiponectin preserves metabolic fitness during aging. Elife. 2021 Apr 27;10:e65108. doi: 10.7554/eLife.65108. PMID: 33904399; PMCID: PMC8099426.
  • Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C (2021). Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metab. 2021 Jun 1;33(6):1155-1170.e10. doi: 10.1016/j.cmet.2021.04.007. Epub 2021 May 4. PMID: 33951475; PMCID: PMC8183500.
  • Stoiljkovic M, Gutierrez KO, Kelley C, Horvath TL, Hajós M (2021). TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice. J Alzheimers Dis. 2021 Jun 8. doi: 10.3233/JAD-210041. Epub ahead of print. PMID: 34120899.
  • Ryu S, Shchukina I, Youm YH, Qing H, Hilliard BK, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna KM, Horvath TL, Dietrich MO, Artyomov MN, Wang A, Dixit VD (2021). Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model. bioRxiv [Preprint]. 2020 Sep 12:2020.09.11.294363. doi: 10.1101/2020.09.11.294363. Update in: Elife. 2021 Jun 21;10: PMID: 33236006; PMCID: PMC7685240.
  • Song JE, Alves TC, Stutz B, Šestan-Peša M, Kilian N, Jin S, Diano S, Kibbey RG, Horvath TL (2021). Mitochondrial Fission Governed by Drp1 Regulates Exogenous Fatty Acid Usage and Storage in Hela Cells. Metabolites. 2021 May 18;11(5):322. doi: 10.3390/metabo11050322. PMID: 34069800; PMCID: PMC8157282.
  • Singh AK, Chaube B, Zhang X, Sun J, Citrin KM, Canfrán-Duque A, Aryal B, Rotllan N, Varela L, Lee RG, Horvath TL, Price N, Suárez Y, Fernandez-Hernando C (2021). Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice. J Clin Invest. 2021 Jul 13;131(17):e140989. doi: 10.1172/JCI140989. Epub ahead of print. PMID: 34255741; PMCID: PMC8409581.
  • Nedel WL, Kopczynski A, Rodolphi MS, Strogulski NR, De Bastiani M, Montes THM, Abruzzi J Jr, Galina A, Horvath TL, Portela LV (2021). Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study. Intensive Care Med Exp. 2021 Jul 24;9(1):39. doi: 10.1186/s40635-021-00404-9. PMID: 34304333; PMCID: PMC8310546.
  • Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M (2021). Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis. Cell Metab. 2021 Sep 7;33(9):1820-1835.e9. doi: 10.1016/j.cmet.2021.07.008. Epub 2021 Aug 2. PMID: 34343501; PMCID: PMC8432968.

Pitter Huesgen

  • Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M. (2021) Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy. Nat Commun. 12:3575.
  • Dall E, Stanojlovic V, Demir F, Briza P, Dahms SO, Huesgen PF, Cabrele C, Brandstetter H. (2021) The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities. ACS Catal. 11:11885-11896.
  • Passarge A, Demir F, Green K, Depotter JRL, Scott B, Huesgen PF, Doehlemann G, Misas Villamil JC (2021). Host apoplastic cysteine protease activity is supressed during the mutualistic association of Lolium perenne and Epichloë festucae. J Exp Bot. 2021 Feb 25:erab088. doi: 10.1093/jxb/erab088. Online ahead of print. PMID: 33630999 
  • Mooney BC, Mantz M, Graciet E, Huesgen PF (2021). Cutting the line: manipulation of plant immunity by bacterial type III effector proteases. J Exp Bot. 2021 Feb 26:erab095. doi: 10.1093/jxb/erab095. Online ahead of print. PMID: 33640987
  • Demir F, Kizhakkedathu JN, Rinschen MM, Huesgen PF (2021). MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets. Anal Chem. 2021 Mar 17. doi: 10.1021/acs.analchem.1c00310. Online ahead of print. PMID: 33729755 
  • Hofsetz E., Huesgen P.F.,Trifunovic A.(2021) Identification of Putative Mitochondrial Protease Substrates. In: Minczuk M., Rorbach J.. Mitochondrial Gene Expression. Methods in Molecular Biology, vol 2192. Humana, New York, NY. doi: 10.1007/978-1-0716-0834-0_21. 
  • Demir F, Troldborg A, Thiel S, Lassé M, Huesgen PF, Tomas NM, Wiech T, Rinschen MM. Proteolysis and inflammation of the kidney glomerulus. Cell Tissue Res. 2021 Apr 17:1–12. doi: 10.1007/s00441-021-03433-8. Epub ahead of print. PMID: 33864499; PMCID: PMC8052535. 
  • Drexelius M, Reinhardt A, Grabeck J, Cronenberg T, Nitsche F, Huesgen PF, Maier B, Neundorf I. Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. Biochem J. 2021 Jan 15;478(1):63-78. doi: 10.1042/BCJ20200698. PMID: 33313751. 
  • Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B (2021). Maintaining proteostasis under mechanical stress. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. PMID: 34309183.
  • Alcaraz LB, Mallavialle A, David T, Derocq D, Delolme F, Dieryckx C, Mollevi C, BoissieÃÄre-Michot F, Simony-Lafontaine J, Du Manoir S, Huesgen PF, Overall CM, Tartare-Deckert S, Jacot W, Chardes T, Guiu S, Roger P, Reinheckel T, Moali C, Liaudet-Coopman E (2021). A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment. Theranostics. 11(13):6173-6192. doi: 10.7150/thno.58254.
  • Mielke, K., Wagner, R., Mishra, L.S., Demir, F., Perrar, A., Huesgen, P.F., and Funk, C. (2021). Abundance of metalloprotease FtsH12 modulates chloroplast development in. J Exp Bot72, 3455-3473. 10.1093/jxb/eraa550.

Sandra Iden 

  • Li M, Iden S (2021) Emerging Laminin-332‒Dependent and ‒Independent Roles for Integrin α3 in Protumorigenic Signaling. J Invest Dermatol. 2021 Apr;141(4):713-716. doi: 10.1016/j.jid.2020.08.017. PMID: 33752808
  • Dias Gomes M, Iden S (2021). Orchestration of tissue-scale mechanics and fate decisions by polarity signalling. EMBO J. 2021 Jun 15;40(12):e106787. doi: 10.15252/embj.2020106787. Epub 2021 May 17. PMID: 33998017

Nach oben

Ron Jachimowicz

  • Jachimowicz RD, Pieper L, Reinke S, Gontarewicz A, Plütschow A, Haverkamp H, Frauenfeld L, Fend F, Overkamp M, Jochims F, Thorns C, Leo Hansmann M, Möller P, Rosenwald A, Stein H, Reinhardt HC, Borchmann P, von Tresckow B, Engert A, Klapper W (2021). Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP. Haematologica. 2021 Jun 1;106(6):1684-1692. doi: 10.3324/haematol.2019.243287. PMID: 32381573; PMCID: PMC8168506.
  • Schmidt J, Goergens J, Pochechueva T, Kotter A, Schwenzer N, Sitte M, Werner G, Altmüller J, Thiele H, Nürnberg P, Isensee J, Li Y, Müller C, Leube B, Reinhardt HC, Hucho T, Salinas G, Helm M, Jachimowicz RD, Wieczorek D, Kohl T, Lehnart SE, Yigit G, Wollnik B (2021). Biallelic variants in YRDC cause a developmental disorder with progeroid features. Hum Genet. 2021 Dec;140(12):1679-1693. doi: 10.1007/s00439-021-02347-3. Epub 2021 Sep 20. PMID: 34545459
  • Jachimowicz RD, Klapper W, Glehr G, Müller H, Haverkamp H, Thorns C, Hansmann ML, Möller P, Stein H, Rehberg T, von Tresckow B, Reinhardt HC, Borchmann P, Chan FC, Spang R, Scott DW, Engert A, Steidl C, Altenbuchinger M, Rosenwald A (2021). Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP. Leukemia. 2021 Dec;35(12):3589-3593. doi: 10.1038/s41375-021-01314-1. Epub 2021 Jun 10. PMID: 34112956
  • Murakami T, Shoji Y, Nishi T, Chang SC, Jachimowicz RD, Hoshimoto S, Ono S, Shiloh Y, Takeuchi H, Kitagawa Y, Hoon DSB, Bustos MA. Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma. Mol Oncol. 2021 Apr;15(4):1069-1087. doi: 10.1002/1878-0261.12929. Epub 2021 Mar 8. PMID: 33605536
  • Mitra, S., Muralidharan, S.V., Di Marco, M., Juvvuna, P.K., Kosalai, S.T., Reischl, S., Jachimowicz, D., Subhash, S., Raimondi, I., Kurian, L., Huarte, M., Kogner, P., Fischer, M., Johnsen, J.I., Mondal, T., and Kanduri, C. (2021). Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma. Cancer Res81, 1457-1471. 10.1158/0008-5472.Can-19-3499.
  • Murakami, T., Shoji, Y., Nishi, T., Chang, S.C., Jachimowicz, R.D., Shiloh, Y., Takeuchi, H., Kitagawa, Y., Hoon, D.S., and Bustos, M.A. (2021). MRE11A expression regulated by UBQLN4 is related to cisplatin-resistance and survival in patients with esophageal squamous cell carcinoma. Cancer Res81.

Frank Jessen

  • Sannemann L, Müller T, Waterink L, Zwan M, Wimo A, Stomrud E, Pinó S, Arrufat J, Rodríguez-Gomez O, Benaque A, Bon J, Ferreira D, Johansson G, Dron A, Dumas A, Georges J, Kramberger MG, Visser PJ, Winblad B, Campo L, Boada M, Jessen F; MOPEAD consortium (2021). General practitioners' attitude toward early and pre-dementia diagnosis of AD in five European countries-A MOPEAD project survey.  Alzheimers Dement (Amst). 2021 Feb 23;13(1):e12130. doi: 10.1002/dad2.12130. eCollection 2021. PMID: 33665337  
  • Hammes J, Bischof GN, Bohn KP, Onur Ö, Schneider A, Fliessbach K, Hönig MC, Jessen F, Neumaier B, Drzezga A, van Eimeren T (2021). One-Stop Shop: 18F-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases. J Nucl Med. 2021 Feb;62(2):240-246. doi: 10.2967/jnumed.120.244061. Epub 2020 Jul 3. PMID: 32620704.
  • Ballarini T, Melo van Lent D, Brunner J, Schröder A, Wolfsgruber S, Altenstein S, Brosseron F, Buerger K, Dechent P, Dobisch L, Duzel E, Ertl-Wagner B, Fliessbach K, Freiesleben SD, Frommann I, Glanz W, Hauser D, Haynes JD, Heneka MT, Janowitz D, Kilimann I, Laske C, Maier F, Metzger CD, Munk M, Perneczky R, Peters O, Priller J, Ramirez A, Rauchmann B, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel SJ, Vukovich R, Wiltfang J, Jessen F, Wagner M; DELCODE study group. Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age. Neurology. 2021 May 5:10.1212/WNL.0000000000012067. doi: 10.1212/WNL.0000000000012067. Epub ahead of print. PMID: 33952652.
  • Hansen N, Singh A, Bartels C, Brosseron F, Buerger K, Cetindag AC, Dobisch L, Dechent P, Ertl-Wagner BB, Fliessbach K, Haynes JD, Heneka MT, Janowitz D, Kilimann I, Laske C, Metzger CD, Munk MH, Peters O, Priller J, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Vukovich R, Wiltfang J, Duezel E, Jessen F, Goya-Maldonado R. Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline. Front Aging Neurosci. 2021 Apr 21;13:626974. doi: 10.3389/fnagi.2021.626974. PMID: 33967736; PMCID: PMC8097178. 
  • Schild AK, Volk J, Scharfenberg D, Schuermann K, Meiberth D, Onur OA, Jessen F, Maier F (2021). Social Cognition in Patients with Amnestic Mild Cognitive Impairment and Mild Dementia of the Alzheimer Type. J Alzheimers Dis. 2021 Aug 13. doi: 10.3233/JAD-201126. Epub ahead of print. PMID: 34397409. 
  • Wimo A, Belger M, Bon J, Jessen F, Dumas A, Kramberger MG, Jamilis L, Johansson G, Rodrigo Salas A, Rodríguez Gómez O, Sannemann L, Stoekenbroek M, Gurruchaga Telleria M, Valero S, Vermunt L, Waterink L, Winblad B, Visser PJ, Zwan M, Boada M; Collaborators and members of the MOPEAD consortium (2021). A Cost-Consequence Analysis of Different Screening Procedures in Alzheimer's Disease: Results from the MOPEAD Project. J Alzheimers Dis. 2021 Aug 16. doi: 10.3233/JAD-210303. Epub ahead of print. PMID: 34420954.
  • Rostamzadeh A, Schwegler C, Gil-Navarro S, Rosende-Roca M, Romotzky V, Ortega G, Canabate P, Moreno M, Schmitz-Luhn B, Boada M, Jessen F, Woopen C (2021). Biomarker-Based Risk Prediction of Alzheimer's Disease Dementia in Mild Cognitive Impairment: Psychosocial, Ethical, and Legal Aspects. J Alzheimers Dis.  2021;80(2):601-617. doi: 10.3233/JAD-200484. PMID: 33554900
  • Frisoni GB, Molinuevo JL, Altomare D, Carrera E, Barkhof F, Berkhof J, Delrieu J, Dubois B, Kivipelto M, Nordberg A, Schott JM, van der Flier WM, Vellas B, Jessen F, Scheltens P, Ritchie C (2021). Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies.Alzheimers Dement. 2020 Oct;16(10):1457-1468. doi: 10.1002/alz.12132. Epub 2020 Aug 20. PMID: 32815289
  • Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimolgu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka MT, Janowitz D, Kilimann I, Kleinedam L, Laske C, Metzger CD, Munk MH, Perneczky R, Peters O, Priller J, Rauchmann BS, Roy N, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Wagner M, Wiltfang J, Düzel E, Jessen F; Delcode Study Group, Rizzoli SO, Zimmermann WH, Schulze TG, Falkai P, Sananbenesi F, Fischer A (2021). A microRNA signature that correlates with cognition and is a target against cognitive decline. EMBO Mol Med.2021 Oct 11:e13659. doi: 10.15252/emmm.202013659. Online ahead of print. PMID: 34633146
  • Marchant NL, Barnhofer T, Coueron R, Wirth M, Lutz A, Arenaza-Urquijo EM, Collette F, Poisnel G, Demnitz-King H, Schild AK, Coll-Padros N, Delphin-Combe F, Whitfield T, Schlosser M, Gonneaud J, Asselineau J, Walker Z, Krolak-Salmon P, Molinuevo JL, Frison E, Chételat G, Jessen F, Klimecki OM; The Medit-Ageing Research Group (2021). Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial. Psychother Psychosom. 2021;90(5):341-350. doi: 10.1159/000515669. Epub 2021 Apr 19. PMID: 33873195 
  • Dyrba M, Hanzig M, Altenstein S, Bader S, Ballarini T, Brosseron F, Buerger K, Cantré D, Dechent P, Dobisch L, Düzel E, Ewers M, Fliessbach K, Glanz W, Haynes JD, Heneka MT, Janowitz D, Keles DB, Kilimann I, Laske C, Maier F, Metzger CD, Munk MH, Perneczky R, Peters O, Preis L, Priller J, Rauchmann B, Roy N, Scheffler K, Schneider A, Schott BH, Spottke A, Spruth EJ, Weber MA, Ertl-Wagner B, Wa gner M, Wiltfang J,Jessen F, Teipel SJ; ADNI, AIBL, DELCODE study groups (2021). Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer's disease.Alzheimers Res Ther. 2021 Nov 23;13(1):191. doi: 10.1186/s13195-021-00924-2.PMID: 34814936
  • Ourry V, Marchant NL, Schild AK, Coll-Padros N, Klimecki OM, Krolak-Salmon P, Goldet K, Reyrolle L, Bachelet R, Sannemann L, Meiberth D, Demnitz-King H, Whitfield T, Botton M, Lebahar J, Gonneaud J, de Flores R, Molinuevo JL, Jessen F, Vivien D, de la Sayette V, Valenzuela MJ, Rauchs G, Wirth M, Chételat G, Arenaza-Urquijo EM; Medit-Ageing Research Group (2021). Harmonisation and Between-Country Differences of the Lifetime of Experiences Questionnaire in Older Adults. Front Aging Neurosci. 2021 Oct 14;13:740005. doi:10.3389/fnagi.2021.740005. PMID: 34720992; PMCID: PMC8551756.
  • Altomare D, Molinuevo JL, Ritchie C, Ribaldi F, Carrera E, Dubois B, JessenF, McWhirter L, Scheltens P, van der Flier WM, Vellas B, Démonet JF, Frisoni GB; European Task Force for Brain Health Services (2021). Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services-part 1 of 6. Alzheimers Res Ther. 2021 Oct 11;13(1):168. doi: 10.1186/s13195-021-00827-2. PMID: 34635163; PMCID: PMC8507194. 
  • Ranson JM, Rittman T, Hayat S, Brayne C, Jessen F, Blennow K, van Duijn C, Barkhof F, Tang E, Mummery CJ, Stephan BCM, Altomare D, Frisoni GB, Ribaldi F, Molinuevo JL, Scheltens P, Llewellyn DJ; European Task Force for Brain Health Services (2021). Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6. Alzheimers Res Ther. 2021 Oct 11;13(1):169. doi: 10.1186/s13195-021-00895-4. PMID: 34635138; PMCID: PMC8507172.
  • Jiang J, Han Y, Jessen F (2021). Editorial: Exploring Reliable Markers and Prediction Indexes for the Progression From Subjective Cognitive Decline to Cognitive Impairment. Front Aging Neurosci. 2021 Sep 20;13:760920. doi: 10.3389/fnagi.2021.760920. PMID: 34616290; PMCID: PMC8488088.
  • Rauchmann BS, Ersoezlue E, Stoecklein S, Keeser D, Brosseron F, Buerger K, Dechent P, Dobisch L, Ertl-Wagner B, Fliessbach K, Haynes JD, Heneka MT, Incesoy EI, Janowitz D, Kilimann I, Laske C, Metzger CD, Munk MH, Peters O, Priller J, Ramirez A, Roeske S, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Vukovich R, Wagner M, Wiltfang J, Yakupov R, Duezel E, Jessen F, Perneczky R; DELCODE study group and the Alzheimer's Disease Neuroimaging Initiative (ADNI) (2021). Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes. Cereb Cortex. 2021 Oct 1;31(11):4901-4915. doi: 10.1093/cercor/bhab130. PMID: 34080613; PMCID: PMC8491689.
  • Song M, Scheifele M, Barthel H, van Eimeren T, Beyer L, Marek K, Eckenweber F, Palleis C, Kaiser L, Finze A, Kern M, Nitschmann A, Biechele G, Katzdobler S, Bischof G, Hammes J, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Stephens AW, Rauchmann BS, Perneczky R, Levin J, Classen J, Höglinger GU, Bartenstein P, Boening G, Ziegler S, Villemagne V, Drzezga A, Seibyl J, Sabri O, Brendel M; German Imaging Initiative for Tauopathies (GII4T) (2021). Feasibility of short imaging protocols for [<sup>18</sup>F]PI-2620 tau-PET in progressive supranuclear palsy. Eur J Nucl Med Mol Imaging. 2021 Nov;48(12):3872-3885. doi: 10.1007/s00259-021-05391-3. Epub 2021 May 22. PMID: 34021393; PMCID: PMC8484138.
  • Rostamzadeh A, Jessen F (2021). Prädiktive Diagnostik der Alzheimer-Demenz [Predictive Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2021 May;89(5):254-266. German. doi: 10.1055/a-1370-3142. Epub 2021 May 18. PMID: 34005829.
  • Rodrigo A, Trigueros P, Jamilis L, Alegret M, Rodríguez O, Tárraga L,González-Pérez A, Kramberger M, Winblad B, Visser PJ, Jessen F, Campo L, Boada M; MOPEAD consortium (2021). Identification of undiagnosed dementia cases using a web-based pre-screening tool: The MOPEAD project. Alzheimers Dement. 2021 Aug;17(8):1307-1316. doi: 10.1002/alz.12297. Epub 2021 Apr 15. PMID: 33860599; PMCID: PMC8453736.
  • Melo van Lent D, Egert S, Wolfsgruber S, Kleineidam L, Weinhold L, Wagner-Thelen H, Maier W, Jessen F, Ramirez A, Schmid M, Scherer M, Riedel-Heller SG, Wagner M (2021). Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old. Nutrients. 2021 Jan 30;13(2):461. doi: 10.3390/nu13020461. PMID: 33573174; PMCID: PMC7912244.
  • Li S, Daamen M, Scheef L, Gaertner FC, Buchert R, Buchmann M, Buerger K, Catak C, Dobisch L, Drzezga A, Ertl-Wagner B, Essler M, Fliessbach K, Haynes JD, Incesoy EI, Kilimann I, Krause BJ, Lange C, Laske C, Priller J, Ramirez A, Reimold M, Rominger A, Roy N, Scheffler K, Maurer A, Schneider A, Spottke A, Spruth EJ, Teipel SJ, Tscheuschler M, Wagner M, Wolfsgruber S, Düzel E, Jessen F, Peters O, Boecker H; DELCODE Study Group (2021). Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status. J Alzheimers Dis. 2021;79(2):493-509. doi: 10.3233/JAD-200472. PMID: 33337359.
  • Hausner L, Frölich L, von Arnim CAF, Bohlken J, Dodel R, Otto M, Rapp M, Schulz J, Supprian T, Wollmer MA, Jessen F; Deutsches Netzwerk Gedächtnisambulanzen (2021). Gedächtnisambulanzen in Deutschland – strukturell-organisatorische Voraussetzungen und Aufgabenfelder [Memory clinics in Germany- structural requirements and areas of responsibility]. Nervenarzt. 2021 Jul;92(7):708-715. German. doi: 10.1007/s00115-020-01007-7. Epub 2020 Oct 6. PMID: 33025072; PMCID: PMC8257515.
  • Brosseron F, Kleemann K, Kolbe CC, Santarelli F, Castro-Gomez S, Tacik P, Latz E, Jessen F, Heneka MT (2021). Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation. J Neurochem. 2021 Jun;157(6):2210-2224. doi: 10.1111/jnc.15175. Epub 2020 Sep 18. PMID: 32894885.
  • Wesselman LMP, van Lent DM, Schröder A, van de Rest O, Peters O, Menne F, Fuentes M, Priller J, Spruth EJ, Altenstein S, Schneider A, Fließbach K, Roeske S, Wolfsgruber S, Kleineidam L, Spottke A, Pross V, Wiltfang J, Vukovich R, Schild AK, Düzel E, Metzger CD, Glanz W, Buerger K, Janowitz D, Perneczky R, Tatò M, Teipel S, Kilimann I, Laske C, Buchmann M, Ramirez A, Sikkes SAM, Jessen F, van der Flier WM, Wagner M (2021). Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease. Eur J Nutr. 2021 Mar;60(2):849-860. doi:10.1007/s00394-020-02257-6. Epub 2020 May 29. PMID: 32472387; PMCID: PMC7900077.
  • Amaefule, C.O., Dyrba, M., Wolfsgruber, S., Polcher, A., Schneider, A., Fliessbach, K., Spottke, A., Meiberth, D., Preis, L., Peters, O., Incesoy, E.I., Spruth, E.J., Priller, J., Altenstein, S., Bartels, C., Wiltfang, J., Janowitz, D., Burger, K., Laske, C., Munk, M., Rudolph, J., Glanz, W., Dobisch, L., Haynes, J.D., Dechent, P., Ertl-Wagner, B., Scheffler, K., Kilimann, I., Duzel, E., Metzger, C.D., Wagner, M., Jessen, F., and Teipel, S.J. (2021). Association between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer's disease spectrum. Neuroimage Clin29, 102533. 10.1016/j.nicl.2020.102533.
  • de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I.E., Pedersen, N.L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R.M., Bis, J.C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., Calero, M., Franco-Macías, E., Macías, J., Blesa, R., Cervera-Carles, L., Menéndez-González, M., Frank-García, A., Royo, J.L., Moreno, F., Vilas, R.H., Baquero, M., Diez-Fairen, M., Lage, C., García-Madrona, S., García-González, P., Alarcón-Martín, E., Valero, S., Sotolongo-Grau, O., Ullgren, A., Naj, A.C., Lemstra, A.W., Benaque, A., Pérez-Cordón, A., Benussi, A., Rábano, A., Padovani, A., Squassina, A., de Mendonça, A., Pastor, A.A., Kok, A.A.L., Meggy, A., Pastor, A.B., Espinosa, A., Corma-Gómez, A., Martín Montes, A., Sanabria, A., DeStefano, A.L., Schneider, A., Haapasalo, A., Ståhlbom, A.K., Tybjærg-Hansen, A., Hartmann, A.M., Spottke, A., Corbatón-Anchuelo, A., Rongve, A., Borroni, B., Arosio, B., Nacmias, B., Nordestgaard, B.G., Kunkle, B.W., Charbonnier, C., Abdelnour, C., Masullo, C., Martínez Rodríguez, C., Muñoz-Fernandez, C., Dufouil, C., Graff, C., Ferreira, C.B., Chillotti, C., Reynolds, C.A., Fenoglio, C., Van Broeckhoven, C., Clark, C., Pisanu, C., Satizabal, C.L., Holmes, C., Buiza-Rueda, D., Aarsland, D., Rujescu, D., Alcolea, D., Galimberti, D., Wallon, D., Seripa, D., Grünblatt, E., Dardiotis, E., Düzel, E., Scarpini, E., Conti, E., Rubino, E., Gelpi, E., Rodriguez-Rodriguez, E., Duron, E., Boerwinkle, E., Ferri, E., Tagliavini, F., Küçükali, F., Pasquier, F., Sanchez-Garcia, F., Mangialasche, F., Jessen, F., Nicolas, G., Selbæk, G., Ortega, G., Chêne, G., Hadjigeorgiou, G., Rossi, G., Spalletta, G., Giaccone, G., Grande, G., Binetti, G., Papenberg, G., Hampel, H., Bailly, H., Zetterberg, H., Soininen, H., Karlsson, I.K., Alvarez, I., Appollonio, I., Giegling, I., Skoog, I., Saltvedt, I., Rainero, I., Allende, I.R., Hort, J., Diehl-Schmid, J., Van Dongen, J., Vidal, J.S., Lehtisalo, J., Wiltfang, J., Thomassen, J.Q., Kornhuber, J., Haines, J.L., Vogelgsang, J., Pineda, J.A., Fortea, J., Popp, J., Deckert, J., Buerger, K., Morgan, K., Fliessbach, K., Sleegers, K., Molina-Porcel, L., Kilander, L., Weinhold, L., Farrer, L.A., Wang, L.S., Kleineidam, L., Farotti, L., Parnetti, L., Tremolizzo, L., Hausner, L., Benussi, L., Froelich, L., Ikram, M.A., Deniz-Naranjo, M.C., Tsolaki, M., Rosende-Roca, M., Löwenmark, M., Hulsman, M., Spallazzi, M., Pericak-Vance, M.A., Esiri, M., Sánchez-Arjona, M.B., Dalmasso, M.C., Martínez-Larrad, M.T., Arcaro, M., Nöthen, M.M., Fernández-Fuertes, M., Dichgans, M., Ingelsson, M., Herrmann, M.J., Scherer, M., Vyhnalek, M., Kosmidis, M.H., Yannakoulia, M., Schmid, M., Ewers, M., Heneka, M.T., Wagner, M., Scamosci, M., Kivipelto, M., Hiltunen, M., Zulaica, M., Alegret, M., Fornage, M., Roberto, N., van Schoor, N.M., Seidu, N.M., Banaj, N., Armstrong, N.J., Scarmeas, N., Scherbaum, N., Goldhardt, O., Hanon, O., Peters, O., Skrobot, O.A., Quenez, O., Lerch, O., Bossù, P., Caffarra, P., Rossi, P.D., Sakka, P., Hoffmann, P., Holmans, P.A., Fischer, P., Riederer, P., Yang, Q., Marshall, R., Kalaria, R.N., Mayeux, R., Vandenberghe, R., Cecchetti, R., Ghidoni, R., Frikke-Schmidt, R., Sorbi, S., Hägg, S., Engelborghs, S., Helisalmi, S., Sando, S.B., Kern, S., Archetti, S., Boschi, S., Fostinelli, S., Gil, S., Mendoza, S., Mead, S., Ciccone, S., Djurovic, S., Heilmann-Heimbach, S., Riedel-Heller, S., Kuulasmaa, T., del Ser, T., Lebouvier, T., Polak, T., Ngandu, T., Grimmer, T., Bessi, V., Escott-Price, V., Giedraitis, V., Deramecourt, V., Maier, W., Jian, X.Q., Pijnenburg, Y.A.L., Smith, A.D., Abdelnour, C., Adarmes-Gómez, A.D., Macleod, C., Jansen, I.E., Kehoe, P.G., Garcia-Ribas, G., Sánchez-Juan, P., Pastor, P., Pérez-Tur, J., Piñol-Ripoll, G., de Munain, A.L., García-Alberca, J.M., Bullido, M.J., Alvarez, V., Lleó, A., Real, L.M., Mir, P., Medina, M., Scheltens, P., Holstege, H., Marquié, M., Sáez, M.E., Carracedo, A., Amouyel, P., Schellenberg, G.D., Williams, J., Seshadri, S., van Duijn, C.M., Mather, K.A., Sánchez-Valle, R., Serrano-Ríos, M., Orellana, A., Tárraga, L., Blennow, K., Huisman, M., Andreassen, O.A., Posthuma, D., Clarimón, J., Boada, M., van der Flier, W.M., Ramirez, A., Lambert, J.C., van der Lee, S.J., Ruiz, A., Contributors, E., Grp, G.S., Consortium, D., IGAP, and Consortia, P.-A. (2021). Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun12. ARTN 3417. 10.1038/s41467-021-22491-8.
  • Franzmeier, N., Ren, J., Damm, A., Monte-Rubio, G., Boada, M., Ruiz, A., Ramirez, A., Jessen, F., Duzel, E., Rodriguez Gomez, O., Benzinger, T., Goate, A., Karch, C.M., Fagan, A.M., McDade, E., Buerger, K., Levin, J., Duering, M., Dichgans, M., Suarez-Calvet, M., Haass, C., Gordon, B.A., Lim, Y.Y., Masters, C.L., Janowitz, D., Catak, C., Wolfsgruber, S., Wagner, M., Milz, E., Moreno-Grau, S., Teipel, S., Grothe, M.J., Kilimann, I., Rossor, M., Fox, N., Laske, C., Chhatwal, J., Falkai, P., Perneczky, R., Lee, J.H., Spottke, A., Boecker, H., Brosseron, F., Fliessbach, K., Heneka, M.T., Nestor, P., Peters, O., Fuentes, M., Menne, F., Priller, J., Spruth, E.J., Franke, C., Schneider, A., Westerteicher, C., Speck, O., Wiltfang, J., Bartels, C., Araque Caballero, M.A., Metzger, C., Bittner, D., Salloway, S., Danek, A., Hassenstab, J., Yakushev, I., Schofield, P.R., Morris, J.C., Bateman, R.J., and Ewers, M. (2021). The BDNF(Val66Met) SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Mol Psychiatry26, 614-628. 10.1038/s41380-019-0404-6.
  • Ophey, A., Wolfsgruber, S., Roeske, S., Polcher, A., Spottke, A., Frolich, L., Hull, M., Jessen, F., Kornhuber, J., Maier, W., Peters, O., Ramirez, A., Wiltfang, J., Liepelt-Scarfone, I., Becker, S., Berg, D., Schulz, J.B., Reetz, K., Wojtala, J., Kassubek, J., Storch, A., Balzer-Geldsetzer, M., Hilker-Roggendorf, R., Witt, K., Mollenhauer, B., Trenkwalder, C., Wittchen, H.U., Riedel, O., Dodel, R., Wagner, M., and Kalbe, E. (2021). Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments. Alzheimers Dement (Amst)13, e12223. 10.1002/dad2.12223.
  • van Lent, D.M., Egert, S., Wolfsgruber, S., Kleineidam, L., Weinhold, L., Wagner-Thelen, H., Maier, W., Jessen, F., Ramirez, A., Schmid, M., Scherer, M., Riedel-Heller, S.G., and Wagner, M. (2021). Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old. Nutrients13. ARTN 461. 10.3390/nu13020461.

Hamid Kashkar      

  • Flümann R, Rehkämper T, Nieper P, Pfeiffer P, Holzem A, Klein S, Bhatia S, Kochanek M, Kisis I, Pelzer BW, Ahlert H, Hauer J, da Palma Guerreiro A, Ryan JA, Reimann M, Riabinska A, Wiederstein J, Krüger M, Deckert M, Altmüller J, Klatt AR, Frenzel LP, Pasqualucci L, Béguelin W, Melnick AM, Sander S, Montesinos-Rongen M, Brunn A, Lohneis P, Büttner R, Kashkar H, Borkhardt A, Letai A, Persigehl T, Peifer M, Schmitt CA, Reinhardt HC, Knittel G (2021). An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discov. 2021 Jan;2(1):70-91. doi: 10.1158/2643-3230.BCD-19-0059. PMID: 33447829 
  • He L, Sehrawat TS, Verma VK, Navarro-Corcuera A, Sidhu G, Mauer A, Luo X, Katsumi T, Chen J, Shah S, Arab JP, Cao S, Kashkar H, Gores GJ, Malhi H, Shah VH (2021). XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivoPhenotypes Owing to a Potential Zonal Inhibitory Role of SMAC. Front Physiol. 2021 May 7;12:664222. doi: 10.3389/fphys.2021.664222. PMID: 34025452; PMCID: PMC8138467. 
  • Geueke A, Mantellato G, Kuester F, Schettina P, Nelles M, Seeger JM, Kashkar H, Niemann C (2021). The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function. EMBO Rep. 2021 Aug 2:e52301. doi: 10.15252/embr.202052301. Epub ahead of print. PMID: 34342114. 
  • Theobald SJ, Simonis A, Georgomanolis T, Kreer C, Zehner M, Eisfeld HS, Albert MC, Chhen J, Motameny S, Erger F, Fischer J, Malin JJ, Gräb J, Winter S, Pouikli A, David F, Böll B, Koehler P, Vanshylla K, Gruell H, Suárez I, Hallek M, Fätkenheuer G, Jung N, Cornely OA, Lehmann C, Tessarz P, Altmüller J, Nürnberg P, Kashkar H, Klein F, Koch M, Rybniker J (2021). Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med. 2021 Aug 9;13(8):e14150. doi: 10.15252/emmm.202114150. Epub 2021 Jun 16. PMID: 34133077; PMCID: PMC8350892.
  • Theobald SJ, Gräb J, Fritsch M, Suárez I, Eisfeld HS, Winter S, Koch M, Hölscher C, Pasparakis M, Kashkar H, Rybniker J (2021). Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages. Cell Death Discov. 2021 Oct 30;7(1):327. doi: 10.1038/s41420-021-00716-5. PMID: 34718331

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Peter Kloppenburg

  • Fuscà D, Kloppenburg P (2021). Odor processing in the cockroach antennal lobe-the network components. Cell Tissue Res. 2021 Jan 23. doi: 10.1007/s00441-020-03387-3. Online ahead of print. PMID: 33486607 Review. 
  • Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC (2021). Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 May 17. doi: 10.1038/s41593-021-00854-0. Epub ahead of print. PMID: 34002087. 
  • Hess S, Pouzat C, Paeger L, Pippow A, Kloppenburg P (2021). Analysis of neuronal Ca2+handling properties by combining perforated patch clamp recordings and the added buffer approach. Cell Calcium. 2021 May 10;97:102411. doi: 10.1016/j.ceca.2021.102411. Epub ahead of print. PMID: 34082340.
  • Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC,Hausen AC (2021). Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun. 2021 Sep 2;12(1):5249. doi: 10.1038/s41467-021-25380-2. PMID: 34475397
  • Fusca D, Kloppenburg P (2021). Task-specific roles of local interneurons for inter- and intraglomerular signaling in the insect antennal lobe.Elife. 2021 Sep 23;10: e65217. doi: 10.7554/eLife.65217. PMID: 34554087
  • Hess S, Pouzat C, Kloppenburg P (2021). Datasets for calcium dynamics comparison between the whole-cell and a β-escin based perforated patch configuration in brain slices from adult mice. Data Brief. 2021 Oct 17;39:107494. doi: 10.1016/j.dib.2021.107494. eCollection 2021 Dec. PMID: 34754890
  • Hess S, Pouzat C, Kloppenburg P (2021). A simple method for getting standard error on the ratiometric calcium estimator. MethodsX. 2021 Oct 22;8:101548. doi: 10.1016/j.mex.2021.101548. eCollection 2021. PMID: 34754816 

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Natalia Kononenko

  • Overhoff, M., De Bruyckere, E., and Kononenko, N.L. (2021). Mechanisms of neuronal survival safeguarded by endocytosis and autophagy. Journal of Neurochemistry157, 263-296. 10.1111/jnc.15194.

Tatiana Korotkova

  • Gao, X.J., Bender, F., Soh, H., Chen, C.W., Altafi, M., Schütze, S., Heidenreich, M., Gorbati, M., Corbu, M.A., Carus-Cadavieco, M., Korotkova, T., Tzingounis, A.V., Jentsch, T.J., and Ponomarenko, A. (2021). Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts. Nat Commun12. ARTN 4801. 10.1038/s41467-021-24805-2.

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Thomas Krieg

  • Schumacher B, Krieg TM (2021). The Aging Skin: From Basic Mechanisms to Clinical Applications. J Invest Dermatol. 2021 Apr;141(4S):949-950. doi: 10.1016/j.jid.2020.12.002. PMID: 33752815
  • Sawant M, Hinz B, Schönborn K, Zeinert I, Eckes B, Krieg T, Schuster R (2021). A story of fibers and stress: Matrix-embedded signals for fibroblast activation in the skin. Wound Repair Regen. Jul;29(4):515-530. doi: 10.1111/wrr.12950. Epub 2021 Jun 17. PMID: 34081361.
  • Sawant, M., Wang, F., Koester, J., Nava, M., Wickström, S., Eckes, B., and Krieg, T. (2021). Collagen-binding integrins are important for orchestrating tissue architecture and fibrotic responses. J Invest Dermatol141, S209-S209.
  • Hughes M, Allanore Y, El Aoufy K, Denton CP, Khanna D, Krieg T, Matucci-Cerinic M. (2021). A Practical Approach to the Management of Digital Ulcers in Patients With Systemic Sclerosis: A Narrative Review. JAMA Dermatol. Jul 1;157(7):851-858. doi: 10.1001/jamadermatol.2021.1463. PMID: 34037677.
  • Talarico R, Aguilera S, Alexander T, Amoura Z, Antunes AM, Arnaud L, Avcin T, Beretta L, Bombardieri S, Burmester GR, Cannizzo S, Cavagna L, Chaigne B, Cornet A, Costedoat-Chalumeau N, Doria A, Ferraris A, Fischer-Betz R, Fonseca JE, Frank C, Gaglioti A, Galetti I, Grunert J, Guimarães V, Hachulla E, Houssiau F, Iaccarino L, Krieg T, Limper M, Malfait F, Mariette X, Marinello D, Martin T, Matthews L, Matucci-Cerinic M, Meyer A, Montecucco C, Mouthon L, Müller-Ladner U, Rednic S, Romão VC, Schneider M, Smith V, Sulli A, Tamirou F, Taruscio D, Taulaigo AV, Terol E, Tincani A, Ticciati S, Turchetti G, van Hagen PM, van Laar JM, Vieira A, de Vries-Bouwstra JK, Cutolo M, Mosca M. (2021). The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET. Nat Rev Rheumatol.  Mar;17(3):177-184. doi: 10.1038/s41584-020-00565-z. Epub 2021 Jan 6. PMID: 33408338; PMCID: PMC7786339.
  • Plikus MV, Krieg T (2021). More than just bricks and mortar: Fibroblasts and ECM in skin health and disease. Exp Dermatol.  Jan;30(1):4-9. doi: 10.1111/exd.14257. PMID: 33349992.

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Martin Krönke

  • Klimka A, Mertins S, Nicolai AK, Rummler LM, Higgins PG, Günther SD, Tosetti B, Krut O, Krönke M (2021). Epitope-specific immunity against Staphylococcus aureus coproporphyrinogen III oxidase. NPJ Vaccines. 2021 Jan 18;6(1):11. doi: 10.1038/s41541-020-00268-2. PMID: 33462229 
  • Tosetti B, Ward B, Grumme D, Herb M, Schramm M, Utermöhlen O, Heukamp LC, Krönke M, Krut O. NOX2 Deficiency Permits Sustained Survival of S. aureus in Macrophages and Contributes to Severity of Infection. Front Immunol. 2021 Mar 22;12:633629. doi: 10.3389/fimmu.2021.633629. PMID: 33868252; PMCID: PMC8044967.

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Marcus Krüger

  • Flümann R, Rehkämper T, Nieper P, Pfeiffer P, Holzem A, Klein S, Bhatia S, Kochanek M, Kisis I, Pelzer BW, Ahlert H, Hauer J, da Palma Guerreiro A, Ryan JA, Reimann M, Riabinska A, Wiederstein J, Krüger M, Deckert M, Altmüller J, Klatt AR, Frenzel LP, Pasqualucci L, Béguelin W, Melnick AM, Sander S, Montesinos-Rongen M, Brunn A, Lohneis P, Büttner R, Kashkar H, Borkhardt A, Letai A, Persigehl T, Peifer M, Schmitt CA, Reinhardt HC, Knittel G (2021). An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discov. 2021 Jan;2(1):70-91. doi: 10.1158/2643-3230.BCD-19-0059. PMID: 33447829 
  • Ianni A, Kumari P, Tarighi S, Simonet NG, Popescu D, Guenther S, Hölper S, Schmidt A, Smolka C, Yue S, Krüger M, Fiorillo C, Vaquero A, Bober E, Braun T (2021). SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2015339118. doi: 10.1073/pnas.2015339118. PMID: 33495326  
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hövelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Büttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2021). Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood. 2021 Feb 4;137(5):646-660. doi: 10.1182/blood.2020005734. PMID: 33538798
  • Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt JK, Voglhuber J, Pricolo MR, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer SJ, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani CN, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer PP, von Maltzahn J, Mühlfeld C, Krüger M, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira AF, Lourenço AP, Alegre-Cebollada J, Kiechl S, Linke WA, Kroemer G, Sedej S (2021). Nicotinamide for the treatment of heart failure with preserved ejection fraction. Sci Transl Med. 2021 Feb 10;13(580):eabd7064. doi: 10.1126/scitranslmed.abd7064
  • Aravamudhan S, Türk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, König T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E, Trifunovic A, Brüning J, Langer T, Braun T, Krüger M (2021). Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. J Mol Cell Cardiol. 2021 Feb 5;154:41-59. doi: 10.1016/j.yjmcc.2021.01.010. Online ahead of print. 
  • Leone M, Cazorla-Vázquez S, Ferrazzi F, Wiederstein JL, Gründl M, Weinstock G, Vergarajauregui S, Eckstein M, Krüger M, Gaubatz S, Engel FB (2021). IQGAP3, a YAP target, is required for proper cell cycle progression and genome stability. Mol Cancer Res. 2021 Jun 28:molcanres.MCR-20-0639-E.2020. doi: 10.1158/1541-7786.MCR-20-0639. Epub ahead of print. PMID: 34183451.  
  • Bock T, Türk C, Aravamudhan S, Keufgens L, Bloch W, Rozsivalova DH, Romanello V, Nogara L, Blaauw B, Trifunovic A, Braun T, Krüger M (2021). PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B. Nat Commun. 2021 Aug 12;12(1):4900. doi: 10.1038/s41467-021-25185-3. PMID: 34385433
  • Koyuncu S, Loureiro R, Lee HJ, Wagle P, Krueger M, Vilchez D (2021). Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Nature. 2021 Aug;596(7871):285-290. doi: 10.1038/s41586-021-03781-z. Epub 2021 Jul 28. PMID: 34321666; PMCID: PMC8357631.
  • Bubb K, Holzer T, Nolte JL, Krüger M, Wilson R, Schlötzer-Schrehardt U, Brinckmann J, Altmüller J, Aszodi A, Fleischhauer L, Clausen-Schaumann H, Probst K, Brachvogel B (2021). Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage. J Biol Chem. 2021 Sep 21:101224. doi: 10.1016/j.jbc.2021.101224. Online ahead of print. PMID: 34560099
  • Klapproth S, Richter K, Türk C, Bock T, Bromberger T, Dominik J, Huck K, Pfaller K, Hess MW, Reichel CA, Krüger M, Nakchbandi IA, Moser M (2021). Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones. J Cell Sci. 2021 Oct 27:jcs.259040. doi: 10.1242/jcs.259040. Online ahead of print. PMID: 34704600
  • Hallenborg P, Jensen BAH, Fjære E, Petersen RK, Belmaâti MS, Rasmussen SS, Gunnarsson JP, Lauritzen P, Cheng KKY, Hermansson M, Sonne SB, Ejsing CS, Xu A, Kratchmarova I, Krüger M, Madsen L, Kristiansen K, Blagoev B (2021). Adipose MDM2 regulates systemic insulin sensitivity. Sci Rep. 2021 Nov 8;11(1):21839. doi: 10.1038/s41598-021-01240-3. PMID: 34750429 
  • Baraldo M, Nogara L, Dumitras GA, Tchampda Dondjang AH, Geremia A, Scalabrin M, Türk C, Telkamp F, Zentilin L, Giacca M, Krüger M, Blaauw B (2021). Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy. FASEB J. 2021 Dec;35(12):e22031. doi: 10.1096/fj.202101054RR.PMID: 34767636
  • Altman T, Ionescu A, Ibraheem A, Priesmann D, Gradus-Pery T, Farberov L, Alexandra G, Shelestovich N, Dafinca R, Shomron N, Rage F, Talbot K, Ward ME, Dori A, Krüger M, Perlson E (2021). Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins. Nat Commun. 2021 Nov 25;12(1):6914. doi: 10.1038/s41467-021-27221-8. PMID: 34824257
  • Boehm V, Kueckelmann S, Gerbracht JV, Kallabis S, Britto-Borges T, Altmüller J, Krüger M, Dieterich C, Gehring NH (2021). SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity. Nat Commun. 2021 Jun 25;12(1):3965. doi: 10.1038/s41467-021-24046-3. PMID: 34172724; PMCID: PMC8233366.
  • Klimpel, A., Stillger, K., Wiederstein, J.L., Kruger, M., and Neundorf, I. (2021). Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells. FEBS J288, 2911-2929. 10.1111/febs.15612.
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Leo Kurian

  • Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, Papantonis A (2021). Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology. Nat Commun. 2021 May 21;12(1):3014. doi: 10.1038/s41467-021-23327-1. PMID: 34021162; PMCID: PMC8140133.
  • Mitra, S., Muralidharan, S.V., Di Marco, M., Juvvuna, P.K., Kosalai, S.T., Reischl, S., Jachimowicz, D., Subhash, S., Raimondi, I., Kurian, L., Huarte, M., Kogner, P., Fischer, M., Johnsen, J.I., Mondal, T., and Kanduri, C. (2021). Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma. Cancer Res81, 1457-1471. 10.1158/0008-5472.Can-19-3499.

Thomas Langer

  • Eiyama A, Aaltonen MJ, Nolte H, Tatsuta T, Langer T (2021). Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling. J Biol Chem. 2021 Jan 23:100335. doi: 10.1016/j.jbc.2021.100335. PMID: 33497623 
  • Sprenger HG, MacVicar T, Bahat A, Fiedler KU, Hermans S, Ehrentraut D, Ried K, Milenkovic D, Bonekamp N, Larsson NG, Nolte H, Giavalisco P, Langer T (2021). Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity. Nat Metab. 2021 Apr 26. doi: 10.1038/s42255-021-00385-9. Epub ahead of print. PMID: 33903774. 
  • Nolte H, Langer T. ComplexFinder: A software package for the analysis of native protein complex fractionation experiments. Biochim Biophys Acta Bioenerg. 2021 Apr 30:148444. doi: 10.1016/j.bbabio.2021.148444. Epub ahead of print. PMID: 33940038. 
  • Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu-Wai-Man P, Reynier P, Wai T (2021).High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med. 2021 May 20:e13579. doi: 10.15252/emmm.202013579. Epub ahead of print. PMID: 34014035.
  • Murschall LM, Peker E, MacVicar T, Langer T, Riemer J (2021). Protein Import Assay into Mitochondria Isolated from Human Cells. Bio Protoc. 2021 Jun 20;11(12):e4057. doi: 10.21769/BioProtoc.4057. PMID: 34263000; PMCID: PMC8260258.
  • Bahat A, MacVicar T, Langer T (2021). Metabolism and Innate Immunity Meet at the Mitochondria. Front Cell Dev Biol. 2021 Jul 27;9:720490. doi: 10.3389/fcell.2021.720490. PMID: 34386501; PMCID: PMC8353256.
  • Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021 Oct 25:S1550-4131(21)00482-4. doi: 10.1016/j.cmet.2021.10.004. Online ahead of print. PMID: 34715039
  • Aravamudhan S, Türk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, König T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E, Trifunovic A, Brüning J, Langer T, Braun T, Krüger M (2021). Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein.  J Mol Cell Cardiol. 2021 May;154:41-59. doi: 10.1016/j.yjmcc.2021.01.010. Epub 2021 Feb 5. PMID: 33549681
  • König T, Nolte H, Aaltonen MJ, Tatsuta T, Krohls M, Stroh T, Langer T and McBride H(2021). MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control. Nat Cell Biol 2021. doi: 10.1038/s41556-021-00798-4. PMID: 34873283
  • Laborenz, J., Bykov, Y. S., Knöringer, K., Räschle, M., Filker, S., Prescianotto-Baschong, C., Spang, A., Tatsuta, T., Langer, T., Storchová, Z., Schuldiner, M., & Herrmann, J. M. (2021). The ER protein Ema19 facilitates the degradation of nonimported mitochondrial precursor proteins. Molecular biology of the cell. doi.org/10.1091/mbc.E20-11-0748. PMID: 33596095.
  • Dennerlein, S., Poerschke, S., Oeljeklaus, S., Wang, C., Richter-Dennerlein, R., Sattmann, J., Bauermeister, D., Hanitsch, E., Stoldt, S., Langer, T., Jakobs, S., Warscheid, B., & Rehling, P. (2021).   Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. eLife.doi.org/10.7554/eLife.68213. PMID: 34969438.
  • MacVicar, T., and Langer, T.  (2021). Mechanometabolism: Mitochondria promote resilience under pressure. Current Biology31, R859-R861. 10.1016/j.cub.2021.05.065.

Marius Lemberg

  • Dederer, V., and Lemberg, M.K. (2021). Transmembrane dislocases: a second chance for protein targeting. Trends in Cell Biology31, 898-911. 10.1016/j.tcb.2021.05.007.
  • Lemberg, M.K., and Strisovsky, K. (2021). Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms. Mol Cell81, 2507-2519. 10.1016/j.molcel.2021.05.004.

Maria Leptin

  • Ding X, Kakanj P, Leptin M, Eming SA (2021). Regulation of the Wound Healing Response during Aging. J Invest Dermatol. 2021 Feb 5;S0022-202X(20)32360-5. doi: 10.1016/j.jid.2020.11.014. Online ahead of print.
  • Parisa Kakanj,Sourabh Bhide, Bernard Moussian,Maria Leptin (2021). Autophagy suppression by TORC1 maintains epithelial plasma membrane integrity and inhibits syncytium formation. bioRxiv. doi: https://doi.org/10.1101/2021.08.05.455228 the EMBO Journal, in press

Ivan Matic

  • Michael Adams , Rahul Sharma , Thomas Colby , Felix Weis , Ivan Matic , Sagar Bhogaraju (2021). Structural basis for protein glutamylation by the Legionella pseudokinase SidJ. Nat Commun. 2021 Oct 26;12(1):6174.  doi: 10.1038/s41467-021-26429-y. PMID: 34702826
  • Gorbunova, V., Buschbeck, M., Cambronne, X.A., Chellappa, K., Corda, D., Du, J., Freichel, M., Gigas, J., Green, A.E., Gu, F., Guberovic, I., Jayabalan, A., Khansahib, I., Mukherjee, S., Seluanov, A., Simon, M.A., Sverkeli, L.J., Kory, N., Levine, D.C., Matic, I., Nikiforov, A., Rack, J.G.M., Imai, S.I., Sinclair, D.A., Toiber, D., Zhao, Y.J., Mostoslavsky, R., Kraus, L., and Guse, A.H. (2021). Meeting Report The 2021 FASEB science research conference on NAD metabolism and signaling. Aging-Us13, 24924-24930.
  • Yaobin Liu , Rukmini Mukherjee , Florian Bonn , Thomas Colby , Ivan Matic , Marius Glogger, Mike Heilemann, Ivan Dikic (2021). Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection.Cell Death Differ. 2021 Oct;28(10):2957-2969. doi: 10.1038/s41418-021-00830-y. Epub 2021 Jul 20.

 

 

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Roman-Ulrich Müller

  • Allmeroth K, Horn M, Kroef V, Miethe S, Müller RU, Denzel MS (2021). Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma. Leukemia.2021 Mar;35(3):887-892. doi: 10.1038/s41375-020-0989-4. Epub 2020 Jul 20. PMID: 32690882 
  • Talyan S, Filipów S, Ignarski M, Smieszek M, Chen H, Kühne L, Butt L, Göbel H, Hoyer-Allo KJR, Koehler FC, Altmüller J, Brinkkötter P, Schermer B, Benzing T, Kann M, Müller RU*, Dieterich C. CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease. Cells. 2021 Mar 20;10(3):692. doi: 10.3390/cells10030692. PMID: 33804736; PMCID: PMC8003990. 
  • Hoyer-Allo KJR, Späth MR, Hanssen R, Johnsen M, Brodesser S, Kaufmann K, Kiefer K, Koehler FC, Göbel H, Kubacki T, Grundmann F, Schermer B, Brüning J, Benzing T, Burst V, Müller RU (2021). Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. Int J Mol Sci. 2021 May 22;22(11):5485. doi: 10.3390/ijms22115485. PMID: 34067475; PMCID: PMC8196977.
  • Pilgram L, Eberwein L, Wille K, Koehler FC, Stecher M, Rieg S, Kielstein JT, Jakob CEM, Rüthrich M, Burst V, Prasser F, Borgmann S, Müller RU, Lanznaster J, Isberner N, Tometten L, Dolff S; LEOSS Study group (2021). Clinical course and predictive risk factors for fatal outcome of SARS-CoV-2 infection in patients with chronic kidney disease. Infection. 2021 Aug;49(4):725-737. doi: 10.1007/s15010-021-01597-7. Epub 2021 Apr 13. PMID: 33851328; PMCID: PMC8043429.
  • Di Cristanziano V, Affeldt P, Trappe M, Wirtz M, Heger E, Knops E, Kaiser R, Stippel D, Müller RU, Holtick U, Scheid C, Kann M, Kurschat CE, Grundmann F (2021). Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients. Microorganisms. 2021 Aug 4;9(8):1666. doi: 10.3390/microorganisms9081666. PMID: 34442744 
  • Koehler FC, Blomberg L, Brehm TT, Büttner S, Cornely OA,Degen O, Di Cristanziano V, Dolff S, Eberwein L, Hoxha E, Hoyer-Allo KJR, Rudolf S, Späth MR, Wanken M, Müller RU, Burst V (2021). Development and design of the Hantavirus registry - HantaReg - for epidemiological studies, outbreaks and clinical studies on hantavirus disease. Clin Kidney J. 2021 Mar 5;14(11):2365-2370. doi: 10.1093/ckj/sfab053. eCollection 2021 Nov. PMID: 34754431 
  • Affeldt P, Koehler FC, Brensing KA, Adam V, Burian J, Butt L, Gies M, Grundmann F, Hinrichs S, Johannis W, Kalisch N, Meyer-Delpho M, Oehm S, Platen E, Schöler C, Heger E, Steger G, Stippel D, Ziegelhöfer A, Benzing T, Klein F, Kurschat C, Müller R-U*, Cristanziano VD(2021). Immune Responses to SARS-CoV-2 Infection and Vaccination in Dialysis Patients and Kidney Transplant Recipients. Microorganisms. 2022; 10(1):4. https://doi.org/10.3390/microorganisms10010004
  • Di Cristanziano, V., Affeldt, P., Burkert, K., Dieplinger, G., Kann, M., Grundmann, F., Benzing, T., Ortwin, A., Kaiser, R., Stippel, D., Kurschat, C., Klein, F., and Müller, R.U. (2021). Monitoring of Antiviral Immune Response as an Indicator of Immunosuppression Intensity and Outcome after Kidney Transplantation: The Vireno Study. Transpl Int34, 63-63.
  • Wahba, R., Vitinius, F., Walczuch, B., Dieplinger, G., Buchner, D., Datta, R., Lurssen, N., Schlosser, H.A., Thomas, M., Muller, R., Kann, M., Hellmich, M., Kurschat, C., and Stippel, D.L. (2021). Hand-Assisted Retroperitoneoscopic Donor Nephrectomy Compared to Anterior Approach Open Donor Nephrectomy: Improved Long-Term Physical Component Score in Health-Related Quality of Life in Living Kidney Donors. Transplant Proc53, 786-792. 10.1016/j.transproceed.2020.08.026.

Carien Niessen

  • Persa OD, Koester J, Niessen CM (2021). Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer. J Invest Dermatol. 2021 Jan 30:S0022-202X(20)32410-6. doi: 10.1016/j.jid.2020.12.012. Online ahead of print. PMID: 33531135 
  • Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Gröne HJ, Graumann PL, Niessen CM, Offermanns S, Wickström SA, Worzfeld T (2021). Mechanochemical control of epidermal stem cell divisions by B-plexins. Nat Commun. 2021 Feb 26;12(1):1308. doi: 10.1038/s41467-021-21513-9. PMID: 33637728 
  • Tayem R, Niemann C, Pesch M, Morgner J, Niessen CM, Wickström SA, Aumailley M (2021). LAMININ 332 IS INDISPENSABLE FOR HOMEOSTATIC EPIDERMAL DIFFERENTIATION PROGRAMS. J Invest Dermatol. 2021 May 6:S0022-202X(21)01215-X. doi: 10.1016/j.jid.2021.04.008. Epub ahead of print. PMID: 33965403. 
  • Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B (2021). Maintaining proteostasis under mechanical stress. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. PMID: 34309183. 
  • Koester J, Miroshnikova YA, Ghatak S, Chacón-Martínez CA, Morgner J, Li X, Atanassov I, Altmüller J, Birk DE, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, Wickström SA (2021). Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nat Cell Biol. 2021 Jul;23(7):771-781. doi: 10.1038/s41556-021-00705-x. Epub 2021 Jul 8. PMID: 34239060.
  • Göbel, K., Wachsmuth, E., Stinn, J., Lim, X., van Steensel, M., and Niessen, C. (2021). Metabolic Signalling in Sebaceous Gland Development and Homeostasis. J Invest Dermatol141, S205-S205.
  • Persa, O.D., Vorhagen, S., Goebel, U., Stinn, J., Dilthey, A., and Niessen, C. (2021). Epidermal aPKC polarity signaling suppresses field cancerization upon loss of p53. J Invest Dermatol141, S191-S191.

Maria Notara

  • Meshko, B., Domday, M., Brosig, S., Cursiefen, C., and Notara, M. (2021). Epithelial-mesenchymal transition markers upregulation in corneal epithelial cells after UV-B irradiation which is irreversible with Resveratrol. Invest Ophth Vis Sci62.
  • Schlereth, S.L., Hos, D., Matthaei, M., Hamrah, P., Schmetterer, L., O'Leary, O., Ullmer, C., Horstmann, J., Bock, F., Wacker, K., Schröder, H., Notara, M., Haagdorens, M., Nuijts, R.M.M.A., Dunker, S., Dickman, M., Fauser, S., Scholl, H.P.N., Wheeler-Schilling, T., and Cursiefen, C. (2021). New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency: Review from the European Vision Institute Special Interest Focus Group Meeting. Ophthalmic Res64, 145-167. 10.1159/000509954.
  • Volatier, T., Cursiefen, C., and Notara, M. (2021). Autophagy in the limbal epithelium during UV-induced stem cell damage. Invest Ophth Vis Sci62.

Stephanie Panier

  • Klaric JA, Wüst S, Panier S (2021). New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response. Front Mol Biosci. 2021 May 7;8:668821. doi: 10.3389/fmolb.2021.668821. PMID: 34026839; PMCID: PMC8138124.

Linda Partridge

  • Fuentealba M, Fabian DK, Dönertaş HM, Thornton JM, Partridge L (2021). Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice. Mech Ageing Dev. 2021 Mar;194:111437. doi: 10.1016/j.mad.2021.111437. Epub 2021 Jan 14. PMID: 33454277
  • Bolukbasi E, Woodling NS, Ivanov DK, Adcott J, Foley A, Rajasingam A, Gittings LM, Aleyakpo B, Niccoli T, Thornton JM, Partridge L (2021). Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2011491118. doi: 10.1073/pnas.2011491118. PMID: 33593901
  • Fabian DK, Melike Dönertaş H, Fuentealba M, Partridge L, Thornton JM (2021). Transposable element landscape in Drosophila populations selected for longevity. Genome Biol Evol. 2021 Feb 17:evab031. doi: 10.1093/gbe/evab031. Online ahead of print. PMID: 33595657
  • Kuan V, Fraser HC, Hingorani M, Denaxas S, Gonzalez-Izquierdo A, Direk K, Nitsch D, Mathur R, Parisinos CA, Lumbers RT, Sofat R, Wong ICK, Casas JP, Thornton JM, Hemingway H, Partridge L, Hingorani AD (2021). Data-driven identification of ageing-related diseases from electronic health records. Sci Rep. 2021 Feb 3;11(1):2938. doi: 10.1038/s41598-021-82459-y. PMID: 33536532 
  • Tain LS, Sehlke R, Meilenbrock RL, Leech T, Paulitz J, Chokkalingam M, Nagaraj N, Grönke S, Fröhlich J, Atanassov I, Mann M, Beyer A, Partridge L. Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. Elife. 2021 Apr 21;10:e67275. doi: 10.7554/eLife.67275. PMID: 33879316; PMCID: PMC8060030. 
  • Annibal A, Tharyan RG, Schonewolff MF, Tam H, Latza C, Auler MMK, Grönke S, Partridge L, Antebi A (2021). Author Correction: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity. Nat Commun. 2021 Aug 12;12(1):5025. doi: 10.1038/s41467-021-24840-z. Erratum for: Nat Commun. 2021 Jun 9;12(1):3486. PMID: 34385439; PMCID: PMC8361093.
  • Nespital T, Neuhaus B, Mesaros A, Pahl A, Partridge L(2021). Lithium can mildly increase health during ageing but not lifespan in mice. Aging Cell. 2021 Oct;20(10):e13479. doi: 10.1111/acel.13479. Epub 2021 Sep 17. PMID: 34532960; PMCID: PMC8520709.
  • Li L, Conradson DM, Bharat V, Kim MJ, Hsieh CH, Minhas PS, Papakyrikos AM, Durairaj AS, Ludlam A, Andreasson KI, Partridge L, Cianfrocco MA, Wang X.(2021). A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation. Nat Metab. 2021 Sep;3(9):1242-1258. doi: 10.1038/s42255-021-00443-2. Epub 2021 Sep 9. PMID: 34504353; PMCID: PMC8460615.
  • Pouikli, A, Parekh, S, Maleszewska, M, Nikopoulou, C, Baghdadi, M, Tripodi, I, Folz-Donahue, K, Hinze, Y, Mesaros, A., Hoey, D, Giavalisco, P, Dowell, R, Partridge, L. & Tessarz, P. (2021). Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature Aging. 1, 810-825.
  • Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF(2021). Autophagy in healthy aging and disease. Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12. PMID: 34901876; PMCID: PMC8659158.
  • Fabian DK, Fuentealba M, Dönertaş HM, Partridge L, Thornton JM(2021). Functional conservation in genes and pathways linking ageing and immunity. Immun Ageing. 2021 May 14;18(1):23. doi: 10.1186/s12979-021-00232-1. PMID: 33990202; PMCID: PMC8120713.
  • Lu YX, Regan JC, Eßer J, Drews LF, Weinseis T, Stinn J, Hahn O, Miller RA, Grönke S, Partridge L(2021). A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Elife. 2021 May 14;10:e62233. doi: 10.7554/eLife.62233. PMID: 33988501; PMCID: PMC8186904.
  • Dzankic PJ, Partridge L(2021). Clinical trials of mTOR inhibitors to boost immunity to viral infection in older adults. Lancet Healthy Longev. 2021 May;2(5):e232-e233. doi: 10.1016/S2666-7568(21)00090-8. Epub 2021 May 6. PMID: 33977282; PMCID: PMC8102037.
  • Niccoli T, Kerr F, Snoeren I, Fabian D, Aleyakpo B, Ivanov D, Sofola-Adesakin O, Cryar A, Adcott J, Thornton J, Partridge L(2021). Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. Brain Commun. 2021 Mar 26;3(2):fcab053. doi: 10.1093/braincomms/fcab053. PMID: 33977265; PMCID: PMC8093921.
  • Dönertaş HM, Fabian DK, Valenzuela MF, Partridge L, Thornton JM(2021): Common genetic associations between age-related diseases. Nat Aging. 2021 Apr;1(4):400-412. doi: 10.1038/s43587-021-00051-5. Epub 2021 Apr 8. PMID: 33959723; PMCID: PMC7610725.
  • Atilano ML, Grönke S, Niccoli T, Kempthorne L, Hahn O, Morón-Oset J, Hendrich O, Dyson M, Adams ML, Hull A, Salcher-Konrad MT, Monaghan A, Bictash M, Glaria I, Isaacs AM, Partridge L(2021). Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila. Elife. 2021 Mar 19;10:e58565. doi: 10.7554/eLife.58565. PMID: 33739284; PMCID: PMC8007214.
  • Kapetanou M, Nespital T, Tain LS, Pahl A, Partridge L, Gonos ES(2021). FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity. Front Cell Dev Biol. 2021 Feb 5;9:625715. doi: 10.3389/fcell.2021.625715. PMID: 33634126; PMCID: PMC7901890.
  • Kaeser, S.A, Lehallier, B, Thinggaard, M, Häsler, L.M, Apel, A, Bergmann, C, Berdnik, D, Jeune, B, Christensen, K, Grönke, S, Partridge, Li, Wyss-Coray, T, Mengel-From, J & Jucker, M. (2021). A neuronal blood marker is associated with mortality in old age. Nature Aging1, 218-225.
  • Catterson, J.H., Minkley, L., Aspe, S., Judd-Mole, S., Moura, A.S., Dyson, M.C., Rajasingam, A., Woodling, N.S., Atilano, M.L., Ahmad, M., Spires-Jones, T.L., and Partridge, L. (2021). Aβ toxicity rescued by ER retention of laminin monomers. Int J Exp Pathol102, 129-130.
  • Lu, J.M., Temp, U., Müller-Hartmann, A., Esser, J., Grönke, S., and Partridge, L. (2021). Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature Aging1, 60-+. 10.1038/s43587-020-00001-7.

Manolis Pasparakis  

  • Kumari S, Van TM, Preukschat D, Schuenke H, Basic M, Bleich A, Klein U, Pasparakis M (2021).NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation. Life Sci Alliance. 2021 Apr 15;4(6):e202000956. doi: 10.26508/lsa.202000956. PMID: 33858959. 
  • Oikonomou N, Schuijs MJ, Chatzigiagkos A, Androulidaki A, Aidinis V, Hammad H, Lambrecht BN, Pasparakis M(2021). Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation. Mucosal Immunol. 2021 May 27. doi: 10.1038/s41385-021-00415-5. Epub ahead of print. PMID: 34045680.
  • Schünke H, Göbel U, Dikic I, Pasparakis M (2021). OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun. 2021 Oct 8;12(1):5912. doi: 10.1038/s41467-021-25945-1. PMID: 34625557
  • Theobald SJ, Gräb J, Fritsch M, Suárez I, Eisfeld HS, Winter S, Koch M, Hölscher C, Pasparakis M, Kashkar H, Rybniker J (2021). Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages. Cell Death Discov. 2021 Oct 30;7(1):327. doi: 10.1038/s41420-021-00716-5. PMID: 34718331
  • Cabeza-Cabrerizo M, Minutti CM, da Costa MP, Cardoso A, Jenkins RP, Kulikauskaite J, Buck MD, Piot C, Rogers N, Crotta S, Whittaker L, Encabo HH, McCauley JW, Allen JE, Pasparakis M, Wack A, Sahai E, Reis E Sousa C (2021). Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity. Sci Immunol. 2021 Nov 5;6(65):eabi9331. doi: 10.1126/sciimmunol.abi9331. Epub 2021 Nov 5. PMID: 34739343
  • Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M(2021). The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. PMID: 34675436 Free PMC article.
  • Hausmann A, Felmy B, Kunz L, Kroon S, Berthold DL, Ganz G, Sandu I, Nakamura T, Zangger NS, Zhang Y, Dolowschiak T, Fattinger SA, Furter M, Müller-Hauser AA, Barthel M, Vlantis K, Wachsmuth L, Kisielow J, Tortola L, Heide D, Heikenwälder M, Oxenius A, Kopf M, Schroeder T, Pasparakis M, Sellin ME, Hardt WD (2021). Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF. J Exp Med. 2021 Nov 1;218(11):e20210862. doi: 10.1084/jem.20210862. Epub 2021 Sep 16. PMID: 34529751 Free PMC article.
  • Herbert A, Wang AH, Jovin TM, Mocarski ES, Pasparakis M, Vasquez KM (2021). Concern over use of the term Z-DNA. Nature. 2021 Jun;594(7863):333. doi: 10.1038/d41586-021-01595-7. PMID: 34131341 No abstract available.

Lena Pernas

  • Pernas L (2021). Cellular Metabolism in the Defense Against Microbes. J Cell Science. 134(5)jcs252023. doi: 10.1242/jcs.252023.PMID: 33558420. 
  • Mehra C, Pernas L (2021). Move it to lose it: Mitocytosis expels damaged mitochondria. Dev Cell. 2021 Jul 26;56(14):2014-2015. doi: 10.1016/j.devcel.2021.07.001. PMID: 34314697. 
  • Medeiros TC, Mehra C, Pernas L (2021). Contact and competition between mitochondria and microbes. Curr Opin Microbiol. 2021 Aug 16;63:189-194. doi: 10.1016/j.mib.2021.07.014. Epub ahead of print. PMID: 34411806.
  • Bean C, Audano M, Varanita T, Favaretto F, Medaglia M, Gerdol M, Pernas L, Stasi F, Giacomello M, Herkenne S, Muniandy M, Heinonen S, Cazaly E, Ollikainen M, Milan G, Pallavicini A, Pietiläinen KH, Vettor R, Mitro N, Scorrano L(2021).  The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites. Nat Metab. 2021 Dec 6. doi: 10.1038/s42255-021-00497-2. Epub ahead of print. PMID: 34873337.

Dominik Pesta

  • Strasser B, Pesta D, Rittweger J, Burtscher J, Burtscher M (2021). Nutrition for Older Athletes: Focus on Sex-Differences. Nutrients. 2021 Apr 22;13(5):1409. doi: 10.3390/nu13051409. PMID: 33922108; PMCID: PMC8143537.
  • Gratl A, Wipper S, Frese JP, Raude B, Greiner A, Pesta D. (2021). The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies. Int J Mol Sci. 2021 Aug 6;22(16):8478. doi: 10.3390/ijms22168478. PMID: 34445191
  • Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D,Calabria E (2021). Human Platelet Mitochondrial Function Reflects Systemic Mitochondrial Alterations: A Protocol for Application in Field Studies. Cells. 2021 Aug 14;10(8):2088. doi: 10.3390/cells10082088. PMID: 34440857
  • Pesta D, Jelenik T, Zaharia OP, Bobrov P, Görgens S, Bódis K, Karusheva Y, Krako Jakovljevic N, Lalic NM, Markgraf DF, Burkart V, Müssig K, Knebel B, Kotzka J, Eckel J, Strassburger K, Szendroedi J, Roden M (2021). NDUFB6 Polymorphism Is Associated With Physical Activity-Mediated Metabolic Changes in Type 2 Diabetes. Front Endocrinol (Lausanne). 2021 Sep 24;12:693683. doi: 10.3389/fendo.2021.693683. eCollection 2021. PMID: 34659107
  • Gratl, A., Pesta, D., Gruber, L., Speichinger, F., Raude, B., Omran, S., Greiner, A., and Frese, J.P. (2021). The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study. J Transl Med19. ARTN 244. 10.1186/s12967-021-02908-0.
  • Hoppel, F., Calabria, E., Pesta, D.H., Kantner-Rumplmair, W., Gnaiger, E., and Burtscher, M. (2021). Effects of Ultramarathon Running on Mitochondrial Function of Platelets and Oxidative Stress Parameters: A Pilot Study. Frontiers in Physiology12. ARTN 632664. 10.3389/fphys.2021.632664.
  • Pafili, K., Kahl, S., Pesta, D., Strassburger, K., Mastrototaro, L., Pützer, J., Dewidar, B., Sarabhai, T., Esposito, I., Schlensak, M., and Roden, M. (2021). Visceral adipose tissue mitochondrial function is reduced in humans with non-alcoholic fatty liver disease and correlates with insulin resistance. Diabetologia64, 49-50.
  • Saatmann, N., Zaharia, O.P., Loenneke, J.P., Roden, M., and Pesta, D.H. (2021). Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes. Trends Endocrin Met32, 106-117. 10.1016/j.tem.2020.11.010.
  • Schumann, T., König, J., von Loeffelholz, C., Vatner, D.F., Zhang, D.Y., Perry, R.J., Bernier, M., Chami, J., Henke, C., Kurzbach, A., El-Agroudy, N.N., Willmes, D.M., Pesta, D., de Cabo, R., Sullivan, J.F.O., Simon, E., Shulman, G.I., Hamilton, B.S., and Birkenfeld, A.L. (2021). Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Communications Biology4. ARTN 826. 10.1038/s42003-021-02279-8.

Boris Pfander

  • Chacin E, Bansal P, Reusswig KU, Diaz-Santin LM, Ortega P, Vizjak P, Gomez-Gonzales B, Müller-Planitz F, Aguilera A, Pfander B, Cheung ACM, Kurat CF*(2021). A CDK-regulated chromatin segregase involved in chromosome replication. Nature Communications. 12, doi: 10.1038/s41467-021-25424-7                                                                                                                                                
  • Capella M, Mandemaker IK, , Caballero LM, den Brave F, Pfander B, Ladurner AG, Jentsch S, Braun S* (2021). Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase. Nature Communications. 12, doi: 10.1038/s41467-021-25205-2                                                                                                                                                            
  • Peritore M, Reusswig KU, Bantele S, Straub T, Pfander B* (2021). Strand-specific ChIP-seq at DNA breaks distinguishes single versus double-stranded DNA binding and refutes single-stranded nucleosomes. Mol Cell, 81(1), 1-13 doi: 10.1016/j.molcel.2021.02.005 
  • Ferreira P, Höfer V, Kronshage N, Marko A, Reusswig KU, Tetik B, Köhler K, Tschernoster N, Altmüller J, Schulze N, Pfander B, Boos D*. (2021) MTBP phosphroylation controls DNA replication origin firing. Scientific Reports, 11(1), 1-14 doi:10.1038/s41598-021-83287

Christina Polidori

  • Rarek MP, Meyer AM, Pickert L, Pilotto A, Benzing T, Burst V, Polidori MC (2021). The prognostic signature of health-related quality of life in older patients admitted to the emergency department: a 6-month follow-up study. Aging Clin Exp Res. 2021 Aug;33(8):2203-2211. doi: 10.1007/s40520-020-01732-8. Epub 2020 Nov 1.PMID: 33135133
  • Pickert L, Meyer AM, Becker I, Heeß A, Noetzel N, Brinkkötter P, Pilotto A, Benzing T, Polidori MC (2021). Role of a multidimensional prognosis in-hospital monitoring for older patients with prolonged stay. Int J Clin Pract. 2021 Jan 6:e13989. doi: 10.1111/ijcp.13989. Online ahead of print. PMID: 33406298 
  • Polidori MC, Sies H, Ferrucci L, Benzing T(2021). COVID-19 mortality as a fingerprint of biological age. Ageing Res Rev. 2021 May;67:101308. doi: 10.1016/j.arr.2021.101308. Epub 2021 Feb 20. PMID: 33621704; PMCID: PMC7896489
  • Meyer AM, Wiebe L, Faust M, Chiapponi C, Brinkkoetter PT, Polidori MC, Bartram MP (2021). Cognitive disorder, depression and gait disturbance in an internal medicine patient-geriatric syndromes in an acute care hospital. Z Gerontol Geriatr. 2021 Feb;54(1):77-80. doi: 10.1007/s00391-020-01811-5. Epub 2020 Nov 13.
  • Kasdorf A, Dust G, Vennedey V, Rietz C, Polidori MC, Voltz R, Strupp J, CoRe Net (2021). What are the risk factors for avoidable transitions in the last year of life? A qualitative exploration of professionals' perspectives for improving care in Germany. BMC Health Serv Res. 2021 Feb 15;21(1):147. doi: 10.1186/s12913-021-06138-4. PMID: 33588851; PMCID: PMC7885553. 
  • Polidori MC, Stahl W, Griffiths HR (2021). Nutritional cognitive neuroscience of aging: Focus on carotenoids and cognitive frailty. Redox Biol. 2021 Aug;44:101996. doi: 10.1016/j.redox.2021.101996. Epub 2021 May 8. PMID: 34090844. 
  • Schäfer M, Körber MI, Vimalathasan R, Mauri V, Iliadis C, Metze C, Ten Freyhaus H, Baldus S, Polidori MC,Pfister R (2021). Risk Stratification of Patients Undergoing Percutaneous Repair of Mitral and Tricuspid Valves Using a Multidimensional Geriatric Assessment. Circ Cardiovasc Qual Outcomes. 2021 Aug;14(8):e007624. doi: 10.1161/CIRCOUTCOMES.120.007624. Epub 2021 Jul 30. PMID: 34325515
  • Stuckenschneider T, Abeln V, Foitschik T, Abel T, Polidori MC, Strüder HK (2021). Disease-inclusive exercise classes improve physical fitness and reduce depressive symptoms in individuals with and without Parkinson's disease-A feasibility study. Brain Behav. 2021 Sep 2:e2352. doi: 10.1002/brb3.2352. Epub ahead of print. PMID: 34472722.
  • Polidori MC, Singler K (2021). [75/f-apathy, nocturnal restlessness and mild disorientation : Preparation for the medical specialist examination: part 70]. Internist (Berl). 2021 Sep 3. doi: 10.1007/s00108-021-01091-0. Online ahead of print. PMID: 34477893.
  • von Gersdorff G, von Korn P, Duvinage A, Ihorst G, Josef A, Kaufmann M, Baer T, Fellerhoff T, Fuhrmann I, Koesel E, Zeissler S, Bobka L, Heinrich M, Schindler A, Weber R, Breuer C, Meyer AM, Polidori MC, Dinges SMT, Schoenfeld J, Siebenbuerger M, Degenhardt S, Anding-Rost K, Halle M (2021). Cluster Randomized Controlled Trial on the Effects of 12 Months of Combined Exercise Training during Hemodialysis in Patients with Chronic Kidney Disease-Study Protocol of the Dialysis Training Therapy (DiaTT) Trial. Methods Protoc. 2021 Aug 31;4(3):60. doi: 10.3390/mps4030060. PMID: 34564306.
  • Noetzel N, Meyer AM, Siri G, Pickert L, Heeß A, Verleysdonk J, Benzing T, Pilotto A, Barbe AG, Polidori MC (2021). The impact of oral health on prognosis of older multimorbid inpatients: the 6-month follow up MPI oral health study (MPIOH). Eur Geriatr Med. 2021 Apr;12(2):263-273. doi: 10.1007/s41999-020-00427-7. Epub 2020 Nov 18. PMID: 33206351
  • Polidori MC, Friedrich C(2021).  [79/f-Fall in the bathroom without serious sequelae : Preparation for the medical specialist examination: part 90]. Internist (Berl). 2021 Nov;62(Suppl 5):580-584. German. doi: 10.1007/s00108-021-01125-7. Epub 2021 Oct 13. PMID: 34643750.

Simon Pöpsel

  • Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E (2021). JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science. 2021 Jan 22;371(6527):eabc3393. doi: 10.1126/science.abc3393. PMID: 33479123

Alvaro Rada-Iglesias

  • Thues C, Valadas JS, Deaulmerie L, Geens A, Chouhan AK, Duran-Romaña R, Schymkowitz J, Rousseau F, Bartusel M, Rehimi R, Rada-Iglesias A, Verstreken P, Van Esch H (2021). MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome. Sci Rep. 2021 Mar 2;11(1):4976. doi: 10.1038/s41598-021-83771-3. PMID: 33654163 
  • Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, Papantonis A (2021). Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology. Nat Commun. 2021 May 21;12(1):3014. doi: 10.1038/s41467-021-23327-1. PMID: 34021162; PMCID: PMC8140133. 
  • Koester J, Miroshnikova YA, Ghatak S, Chacón-Martínez CA, Morgner J, Li X, Atanassov I, Altmüller J, Birk DE, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, Wickström SA. Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nat Cell Biol. 2021 Jul;23(7):771-781. doi: 10.1038/s41556-021-00705-x. Epub 2021 Jul 8. PMID: 34239060.
  • Crispatzu G, Rehimi R, Pachano T, Bleckwehl T, Cruz-Molina S, Xiao C, Mahabir E, Bazzi H, Rada-Iglesias A (2021). The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo. Nat Commun. 2021 Jul 16;12(1):4344. doi: 10.1038/s41467-021-24641-4. PMID: 34272393; PMCID: PMC8285398.
  • Pachano T, Sánchez-Gaya V, Ealo T, Mariner-Faulí M, Bleckwehl T, Asenjo HG, Respuela P, Cruz-Molina S, Muñoz-San Martín M, Haro E, van IJcken WFJ, Landeira D, Rada-Iglesias A(2021). Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness. Nat Genet. 2021 Jul;53(7):1036-1049. doi: 10.1038/s41588-021-00888-x. Epub 2021 Jun 28. PMID: 34183853
  • Bleckwehl T, Crispatzu G, Schaaf K, Respuela P, Bartusel M, Benson L, Clark SJ, Dorighi KM, Barral A, Laugsch M, van IJcken WFJ, Manzanares M, Wysocka J, Reik W, Rada-Iglesias Á (2021). Enhancer-associated H3K4 methylation safeguards in vitro germline competence. Nat Commun. 2021 Oct 1;12(1):5771. doi: 10.1038/s41467-021-26065-6.PMID: 34599190
  • Welzenbach, J., Hammond, N.L., Nikolic, M., Thieme, F., Ishorst, N., Leslie, E.J., Weinberg, S.M., Beaty, T.H., Marazita, M.L., Mangold, E., Knapp, M., Cotney, J., Rada-Iglesias, A., Dixon, M.J., and Ludwig, K.U. (2021). Integrative approaches generate insights into the architecture of non-syndromic cleft lip with or without cleft palate. Hum Genet Genom Adv2. ARTN 100038. 10.1016/j.xhgg.2021.100038.

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Alfredo Ramirez

  • Heinzel S, Kaufmann C, Grützmann R, Klawohn J, Riesel A, Bey K, Heilmann-Heimbach S, Weinhold L, Ramirez A, Wagner M, Kathmann N (2021). Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls. Sci Rep. 2021 Sep 23;11(1):18914. doi: 10.1038/s41598-021-98333-w. PMID: 34556731
  • Schönknecht YB, Crommen S, Stoffel-Wagner B, Coenen M, Fimmers R, Stehle P, Ramirez A, Egert S (2021). APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits. Nutrients. 2021 Nov 2;13(11):3924. doi: 10.3390/nu13113924. PMID: 34836179 
  • Ballarini, T., Melo van Lent, D., Brunner, J., Schroder, A., Wolfsgruber, S., Altenstein, S., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Duzel, E., Ertl-Wagner, B., Fliessbach, K., Freiesleben, S.D., Frommann, I., Glanz, W., Hauser, D., Haynes, J.D., Heneka, M.T., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Metzger, C.D., Munk, M., Perneczky, R., Peters, O., Priller, J., Ramirez, A., Rauchmann, B., Roy, N., Scheffler, K., Schneider, A., Spottke, A., Spruth, E.J., Teipel, S.J., Vukovich, R., Wiltfang, J., Jessen, F., Wagner, M., and group, D.s. (2021). Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age. Neurology96, e2920-e2932. 10.1212/WNL.0000000000012067.
  • Ballarini, T., van Lent, D.M., Brunner, J., Schröder, A., Wolfsgruber, S., Altenstein, S., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Düzel, E., Ertl-Wagner, B., Fliessbach, K., Freiesleben, S.D., Frommann, I., Glanz, W., Hauser, D., Haynes, J.D., Heneka, M.T., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Metzger, C.D., Munk, M., Perneczky, R., Peters, O., Priller, J., Ramirez, A., Rauchmann, B., Roy, N., Scheffler, K., Schneider, A., Spottke, A., Spruth, E.J., Teipel, S.J., Vukovich, R., Wiltfang, J., Jessen, F., Wagner, M., and Grp, D.S. (2021). Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age. Neurology96, E2920-E2932. 10.1212/Wnl.0000000000012067.
  • Bey, K., Campos-Martin, R., Klawohn, J., Reuter, B., Grützmann, R., Riesel, A., Wagner, M., Ramirez, A., and Kathmann, N. (2021). Hypermethylation of the Oxytocin Receptor Gene in Obsessive-Compulsive Disorder: Further Evidence for a Biomarker of Disease and Treatment Response. Eur Neuropsychopharm51, E224-E224. 10.1016/j.euroneuro.2021.08.228.
  • de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I.E., Pedersen, N.L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R.M., Bis, J.C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., Calero, M., Franco-Macías, E., Macías, J., Blesa, R., Cervera-Carles, L., Menéndez-González, M., Frank-García, A., Royo, J.L., Moreno, F., Vilas, R.H., Baquero, M., Diez-Fairen, M., Lage, C., García-Madrona, S., García-González, P., Alarcón-Martín, E., Valero, S., Sotolongo-Grau, O., Ullgren, A., Naj, A.C., Lemstra, A.W., Benaque, A., Pérez-Cordón, A., Benussi, A., Rábano, A., Padovani, A., Squassina, A., de Mendonça, A., Pastor, A.A., Kok, A.A.L., Meggy, A., Pastor, A.B., Espinosa, A., Corma-Gómez, A., Martín Montes, A., Sanabria, A., DeStefano, A.L., Schneider, A., Haapasalo, A., Ståhlbom, A.K., Tybjærg-Hansen, A., Hartmann, A.M., Spottke, A., Corbatón-Anchuelo, A., Rongve, A., Borroni, B., Arosio, B., Nacmias, B., Nordestgaard, B.G., Kunkle, B.W., Charbonnier, C., Abdelnour, C., Masullo, C., Martínez Rodríguez, C., Muñoz-Fernandez, C., Dufouil, C., Graff, C., Ferreira, C.B., Chillotti, C., Reynolds, C.A., Fenoglio, C., Van Broeckhoven, C., Clark, C., Pisanu, C., Satizabal, C.L., Holmes, C., Buiza-Rueda, D., Aarsland, D., Rujescu, D., Alcolea, D., Galimberti, D., Wallon, D., Seripa, D., Grünblatt, E., Dardiotis, E., Düzel, E., Scarpini, E., Conti, E., Rubino, E., Gelpi, E., Rodriguez-Rodriguez, E., Duron, E., Boerwinkle, E., Ferri, E., Tagliavini, F., Küçükali, F., Pasquier, F., Sanchez-Garcia, F., Mangialasche, F., Jessen, F., Nicolas, G., Selbæk, G., Ortega, G., Chêne, G., Hadjigeorgiou, G., Rossi, G., Spalletta, G., Giaccone, G., Grande, G., Binetti, G., Papenberg, G., Hampel, H., Bailly, H., Zetterberg, H., Soininen, H., Karlsson, I.K., Alvarez, I., Appollonio, I., Giegling, I., Skoog, I., Saltvedt, I., Rainero, I., Allende, I.R., Hort, J., Diehl-Schmid, J., Van Dongen, J., Vidal, J.S., Lehtisalo, J., Wiltfang, J., Thomassen, J.Q., Kornhuber, J., Haines, J.L., Vogelgsang, J., Pineda, J.A., Fortea, J., Popp, J., Deckert, J., Buerger, K., Morgan, K., Fliessbach, K., Sleegers, K., Molina-Porcel, L., Kilander, L., Weinhold, L., Farrer, L.A., Wang, L.S., Kleineidam, L., Farotti, L., Parnetti, L., Tremolizzo, L., Hausner, L., Benussi, L., Froelich, L., Ikram, M.A., Deniz-Naranjo, M.C., Tsolaki, M., Rosende-Roca, M., Löwenmark, M., Hulsman, M., Spallazzi, M., Pericak-Vance, M.A., Esiri, M., Sánchez-Arjona, M.B., Dalmasso, M.C., Martínez-Larrad, M.T., Arcaro, M., Nöthen, M.M., Fernández-Fuertes, M., Dichgans, M., Ingelsson, M., Herrmann, M.J., Scherer, M., Vyhnalek, M., Kosmidis, M.H., Yannakoulia, M., Schmid, M., Ewers, M., Heneka, M.T., Wagner, M., Scamosci, M., Kivipelto, M., Hiltunen, M., Zulaica, M., Alegret, M., Fornage, M., Roberto, N., van Schoor, N.M., Seidu, N.M., Banaj, N., Armstrong, N.J., Scarmeas, N., Scherbaum, N., Goldhardt, O., Hanon, O., Peters, O., Skrobot, O.A., Quenez, O., Lerch, O., Bossù, P., Caffarra, P., Rossi, P.D., Sakka, P., Hoffmann, P., Holmans, P.A., Fischer, P., Riederer, P., Yang, Q., Marshall, R., Kalaria, R.N., Mayeux, R., Vandenberghe, R., Cecchetti, R., Ghidoni, R., Frikke-Schmidt, R., Sorbi, S., Hägg, S., Engelborghs, S., Helisalmi, S., Sando, S.B., Kern, S., Archetti, S., Boschi, S., Fostinelli, S., Gil, S., Mendoza, S., Mead, S., Ciccone, S., Djurovic, S., Heilmann-Heimbach, S., Riedel-Heller, S., Kuulasmaa, T., del Ser, T., Lebouvier, T., Polak, T., Ngandu, T., Grimmer, T., Bessi, V., Escott-Price, V., Giedraitis, V., Deramecourt, V., Maier, W., Jian, X.Q., Pijnenburg, Y.A.L., Smith, A.D., Abdelnour, C., Adarmes-Gómez, A.D., Macleod, C., Jansen, I.E., Kehoe, P.G., Garcia-Ribas, G., Sánchez-Juan, P., Pastor, P., Pérez-Tur, J., Piñol-Ripoll, G., de Munain, A.L., García-Alberca, J.M., Bullido, M.J., Alvarez, V., Lleó, A., Real, L.M., Mir, P., Medina, M., Scheltens, P., Holstege, H., Marquié, M., Sáez, M.E., Carracedo, A., Amouyel, P., Schellenberg, G.D., Williams, J., Seshadri, S., van Duijn, C.M., Mather, K.A., Sánchez-Valle, R., Serrano-Ríos, M., Orellana, A., Tárraga, L., Blennow, K., Huisman, M., Andreassen, O.A., Posthuma, D., Clarimón, J., Boada, M., van der Flier, W.M., Ramirez, A., Lambert, J.C., van der Lee, S.J., Ruiz, A., Contributors, E., Grp, G.S., Consortium, D., IGAP, and Consortia, P.-A. (2021). Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun12. ARTN 3417. 10.1038/s41467-021-22491-8.
  • Franzmeier, N., Ren, J., Damm, A., Monte-Rubio, G., Boada, M., Ruiz, A., Ramirez, A., Jessen, F., Duzel, E., Rodriguez Gomez, O., Benzinger, T., Goate, A., Karch, C.M., Fagan, A.M., McDade, E., Buerger, K., Levin, J., Duering, M., Dichgans, M., Suarez-Calvet, M., Haass, C., Gordon, B.A., Lim, Y.Y., Masters, C.L., Janowitz, D., Catak, C., Wolfsgruber, S., Wagner, M., Milz, E., Moreno-Grau, S., Teipel, S., Grothe, M.J., Kilimann, I., Rossor, M., Fox, N., Laske, C., Chhatwal, J., Falkai, P., Perneczky, R., Lee, J.H., Spottke, A., Boecker, H., Brosseron, F., Fliessbach, K., Heneka, M.T., Nestor, P., Peters, O., Fuentes, M., Menne, F., Priller, J., Spruth, E.J., Franke, C., Schneider, A., Westerteicher, C., Speck, O., Wiltfang, J., Bartels, C., Araque Caballero, M.A., Metzger, C., Bittner, D., Salloway, S., Danek, A., Hassenstab, J., Yakushev, I., Schofield, P.R., Morris, J.C., Bateman, R.J., and Ewers, M. (2021). The BDNF(Val66Met) SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Mol Psychiatry26, 614-628. 10.1038/s41380-019-0404-6.
  • Li, S.M., Daamen, M., Scheef, L., Gaertner, F.C., Buchert, R., Buchmann, M., Buerger, K., Catak, C., Dobisch, L., Drzezga, A., Ertl-Wagner, B., Essler, M., Fliessbach, K., Haynes, J.D., Incesoy, E.I., Kilimann, I., Krause, B.J., Lange, C., Laske, C., Priller, J., Ramirez, A., Reimold, M., Rominger, A., Roy, N., Scheffler, K., Maurer, A., Schneider, A., Spottke, A., Spruth, E.J., Teipel, S.J., Tscheuschler, M., Wagner, M., Wolfsgruber, S., Düzel, E., Jessen, F., Peters, O., Boecker, H., and Grp, D.S. (2021). Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status. J Alzheimers Dis79, 493-509. 10.3233/Jad-200472.
  • Madrid, L., Moreno-Grau, S., Ahmad, S., González-Pérez, A., de Rojas, I., Xia, R., Adami, P.V.M., Garcia-González, P., Kleineidam, L., Yang, Q., Damotte, V., Bis, J.C., Noguera-Perea, F., Bellenguez, C., Jian, X.Q., Marin-Muñoz, J., Grenier-Boley, B., Orellana, A., Ikram, M.A., Amouyel, P., Satizabal, C.L., Real, L.M., Antúnez-Almagro, C., DeStefano, A., Cabrera-Socorro, A., Sims, R., Van Duijn, C.M., Boerwinkle, E., Ramírez, A., Fornage, M., Lambert, J.C., Williams, J., Seshadri, S., Ried, J.S., Ruiz, A., Saez, M.E., Initi, A.s.D.N., consortium, E., consortium, C., consortium, G., consortium, G.D., and consortium, A. (2021). Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis. Aging-Us13, 9277-9329.
  • Maraki, M.I., Hatzimanolis, A., Mourtzi, N., Stefanis, L., Yannakoulia, M., Kosmidis, M.H., Dardiotis, E., Hadjigeorgiou, G.M., Sakka, P., Ramirez, A., Grenier-Boley, B., Lambert, J.C., Heilmann-Heimbach, S., Stamelou, M., Scarmeas, N., and Xiromerisiou, G. (2021). Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson's Disease in Older Adults. Frontiers in Molecular Neuroscience14. ARTN 739571.10.3389/fnmol.2021.739571.
  • Melo van Lent, D., Egert, S., Wolfsgruber, S., Kleineidam, L., Weinhold, L., Wagner-Thelen, H., Maier, W., Jessen, F., Ramirez, A., Schmid, M., Scherer, M., Riedel-Heller, S.G., and Wagner, M. (2021). Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old. Nutrients13. 10.3390/nu13020461.
  • Ophey, A., Wolfsgruber, S., Roeske, S., Polcher, A., Spottke, A., Frolich, L., Hull, M., Jessen, F., Kornhuber, J., Maier, W., Peters, O., Ramirez, A., Wiltfang, J., Liepelt-Scarfone, I., Becker, S., Berg, D., Schulz, J.B., Reetz, K., Wojtala, J., Kassubek, J., Storch, A., Balzer-Geldsetzer, M., Hilker-Roggendorf, R., Witt, K., Mollenhauer, B., Trenkwalder, C., Wittchen, H.U., Riedel, O., Dodel, R., Wagner, M., and Kalbe, E. (2021). Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments. Alzheimers Dement (Amst)13, e12223. 10.1002/dad2.12223.
  • Rauchmann, B.S., Ersoezlue, E., Stoecklein, S., Keeser, D., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., Ertl-Wagner, B., Fliessbach, K., Haynes, J.D., Heneka, M.T., Incesoy, E.I., Janowitz, D., Kilimann, I., Laske, C., Metzger, C.D., Munk, M.H., Peters, O., Priller, J., Ramirez, A., Roeske, S., Roy, N., Scheffler, K., Schneider, A., Spottke, A., Spruth, E.J., Teipel, S., Tscheuschler, M., Vukovich, R., Wagner, M., Wiltfang, J., Yakupov, R., Duezel, E., Jessen, F., Perneczky, R., group, D.s., and the Alzheimer's Disease Neuroimaging, I. (2021). Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes. Cereb Cortex31, 4901-4915. 10.1093/cercor/bhab130.
  • Schmid, B., Holst, B., Clausen, C., Bahnassawy, L., Reinhardt, P., Bakker, M.H.M., Díaz-Guerra, E., Vicario, C., Martino-Adami, P.V., Thoenes, M., Ramirez, A., Flissbach, K., Grezella, C., Brüstle, O., Peitz, M., Ebneth, A., and Cabrera-Socorro, A. (2021). Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (ε2/ε3/ε4) and knock-out for the study of APOE biology in health and disease. Stem Cell Research52. ARTN 102180. 10.1016/j.scr.2021.102180.
  • van Lent, D.M., Egert, S., Wolfsgruber, S., Kleineidam, L., Weinhold, L., Wagner-Thelen, H., Maier, W., Jessen, F., Ramirez, A., Schmid, M., Scherer, M., Riedel-Heller, S.G., and Wagner, M. (2021). Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old. Nutrients13. ARTN 461. 10.3390/nu13020461.
  • Wesselman, L.M.P., van Lent, D.M., Schroder, A., van de Rest, O., Peters, O., Menne, F., Fuentes, M., Priller, J., Spruth, E.J., Altenstein, S., Schneider, A., Fliessbach, K., Roeske, S., Wolfsgruber, S., Kleineidam, L., Spottke, A., Pross, V., Wiltfang, J., Vukovich, R., Schild, A.K., Duzel, E., Metzger, C.D., Glanz, W., Buerger, K., Janowitz, D., Perneczky, R., Tato, M., Teipel, S., Kilimann, I., Laske, C., Buchmann, M., Ramirez, A., Sikkes, S.A.M., Jessen, F., van der Flier, W.M., and Wagner, M. (2021). Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease. Eur J Nutr60, 849-860. 10.1007/s00394-020-02257-6.

Hans Christian Reinhardt

  • Flümann R, Rehkämper T, Nieper P, Pfeiffer P, Holzem A, Klein S, Bhatia S, Kochanek M, Kisis I, Pelzer BW, Ahlert H, Hauer J, da Palma Guerreiro A, Ryan JA, Reimann M, Riabinska A, Wiederstein J, Krüger M, Deckert M, Altmüller J, Klatt AR, Frenzel LP, Pasqualucci L, Béguelin W, Melnick AM, Sander S, Montesinos-Rongen M, Brunn A, Lohneis P, Büttner R, Kashkar H, Borkhardt A, Letai A, Persigehl T, Peifer M, Schmitt CA, Reinhardt HC, Knittel G (2021). An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discov. 2021 Jan;2(1):70-91. doi: 10.1158/2643-3230.BCD-19-0059. PMID: 33447829 
  • Lennartz S, Mager A, Große Hokamp N, Schäfer S, Zopfs D, Maintz D, Reinhardt HC, Thomas RK, Caldeira L, Persigehl T (2021). Texture analysis of iodine maps and conventional images for k-nearest neighbor classification of benign and metastatic lung nodules. Cancer Imaging. 2021 Jan 26;21(1):17. doi: 10.1186/s40644-020-00374-3. PMID: 33499939 
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hövelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Büttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2021). Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood. 2021 Feb 4;137(5):646-660. doi: 10.1182/blood.2020005734. PMID: 33538798 
  • Klein S, Quaas A, Quantius J, Löser H, Meinel J, Peifer M, Wagner S, Gattenlöhner S, Wittekindt C, Doeberitz MVK, Prigge ES, Langer C, Noh KW, Maltseva M, Reinhardt HC, Büttner R, Klussmann JP, Wuerdemann N (2021). Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains. Clin Cancer Res. 2021 Feb 15;27(4):1131-1138.  doi: 10.1158/1078-0432.CCR-20-3596. Epub 2020 Dec 1
  • Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Höhne MN, Stüker L, de Pádua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J,  George J, Brodesser S, Thomas RK, Reinhardt HC, von Karstedt S (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021 Apr 6;12(1):2048. doi: 10.1038/s41467-021-22336-4 
  • Jachimowicz RD, Pieper L, Reinke S, Gontarewicz A, Plütschow A, Haverkamp H, Frauenfeld L, Fend F, Overkamp M, Jochims F, Thorns C, Leo Hansmann M, Möller P, Rosenwald A, Stein H, Reinhardt HC, Borchmann P, von Tresckow B, Engert A, Klapper W (2021). Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP. Haematologica. 2021 Jun 1;106(6):1684-1692. doi: 10.3324/haematol.2019.243287. PMID: 32381573; PMCID: PMC8168506.
  • Farber M, Chen Y, Arnold L, Möllmann M, Boog-Whiteside E, Lin YA, Reinhardt HC,Dührsen U, Hanoun M (2021). Targeting CD38 in acute myeloid leukemia interferes with leukemia trafficking and induces phagocytosis. Sci Rep. 2021 Nov 11;11(1):22062. doi: 10.1038/s41598-021-01300-8. PMID: 34764342; PMCID: PMC8586007.
  • Leypoldt LB, Besemer B, Asemissen AM, Hänel M, Blau IW, Görner M, Ko YD, Reinhardt HC, Staib P, Mann C, Lutz R, Munder M, Graeven U, Peceny R, Salwender H, Jauch A, Zago M, Benner A, Tichy D, Bokemeyer C, Goldschmidt H, Weisel KC (2021). Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma: interim analysis of the GMMG-CONCEPT trial. Leukemia. 2021 Nov 3. doi: 10.1038/s41375-021-01431-x. Epub ahead of print. PMID: 34732857.
  • Lindemann M, Klisanin V, Thümmler L, Fisenkci N, Tsachakis-Mück N, Ditschkowski M, Schwarzkopf S, Klump H, Reinhardt HC, Horn PA, Koldehoff M (2021). Humoral and Cellular Vaccination Responses against SARS-CoV-2 in Hematopoietic Stem Cell Transplant Recipients. Vaccines (Basel). 2021 Sep 25;9(10):1075. doi: 10.3390/vaccines9101075. PMID: 34696183; PMCID: PMC8537291.
  • Kordelas L, Buttkereit U, Heinemann FM, Horn PA, Giebel B, Beelen DW, Reinhardt HC,Rebmann V (2021). Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival. Front Immunol. 2021 Sep 24;12:694843. doi: 10.3389/fimmu.2021.694843. PMID: 34630383; PMCID: PMC8498033.
  • Proske P, Distelmaier L, Aramayo-Singelmann C, Koliastas N, Iannaccone A, Papathanasiou M, Temme C, Klump H, Lenz V, Koldehoff M, Carpinteiro A, Reinhardt HC, Köninger A, Röth A, Yamamoto R, Dührsen U, Alashkar F(2021). Pregnancies and Neonatal Outcomes in Patients with Sickle Cell Disease (SCD): Still a (High-)Risk Constellation? J Pers Med. 2021 Aug 30;11(9):870. doi: 10.3390/jpm11090870. PMID: 34575647; PMCID: PMC8464744.
  • Schmidt J, Goergens J, Pochechueva T, Kotter A, Schwenzer N, Sitte M, Werner G, Altmüller J, Thiele H, Nürnberg P, Isensee J, Li Y, Müller C, Leube B, Reinhardt HC, Hucho T, Salinas G, Helm M, Jachimowicz RD, Wieczorek D, Kohl T, Lehnart SE, Yigit G, Wollnik B (2021). Biallelic variants in YRDC cause a developmental disorder with progeroid features. Hum Genet. 2021 Dec;140(12):1679-1693. doi: 10.1007/s00439-021-02347-3. Epub 2021 Sep 20. PMID: 34545459; PMCID: PMC8553732.
  • Pacholewska A, Grimm C, Herling CD, Lienhard M, Königs A, Timmermann B, Altmüller J, Mücke O, Reinhardt HC, Plass C, Herwig R, Hallek M, Schweiger MR.(2021). Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients. Int J Mol Sci. 2021 Aug 28;22(17):9337. doi: 10.3390/ijms22179337. PMID: 34502260; PMCID: PMC8431484.
  • von Tresckow J, von Tresckow B, Reinhardt HC, Herrmann K, Berliner C(2021). Thymic hyperplasia after mRNA based Covid-19 vaccination. Radiol Case Rep. 2021 Dec;16(12):3744-3745. doi: 10.1016/j.radcr.2021.08.050. Epub 2021 Aug 26. PMID: 34462647; PMCID: PMC8387216.
  • Baron F, Ngoya M, Labopin M, Cornelissen JJ, Ganser A, Forcade E, Sengeloev H, Socié G, Blaise D, Bornhäuser M, Valerius T, Reinhardt HC, Kröger N, Ruggeri A, Nagler A, Mohty M (2021).  Comparison of long-term outcome for AML patients alive free of disease 2 years after allogeneic hematopoietic cell transplantation with umbilical cord blood versus unrelated donor: a study from the ALWP of the EBMT. Bone Marrow Transplant. 2021 Nov;56(11):2742-2748. doi: 10.1038/s41409-021-01387-7. Epub 2021 Jul 10. PMID: 34247199.
  • Mülling N, Rosery V, Reinhardt HC, Hanoun M(2021).  Factor IX p.A37V mutation causes severe bleeding in a patient with phenprocoumon therapy. Eur J Med Res. 2021 Jun 29;26(1):63. doi: 10.1186/s40001-021-00533-7. PMID: 34187575; PMCID: PMC8243751.
  • Oubari S, Naser E, Papathanasiou M, Luedike P, Hagenacker T, Thimm A, Rischpler C, Kessler L, Kimmich C, Hegenbart U, Schönland S, Rassaf T, Reinhardt HC, Jöckel KH, Dürig J, Dührsen U, Carpinteiro A (2021). Impact of time to diagnosis on Mayo stages, treatment outcome, and survival in patients with AL amyloidosis and cardiac involvement. Eur J Haematol. 2021 Oct;107(4):449-457. doi: 10.1111/ejh.13681. Epub 2021 Jul 9. PMID: 34185342.
  • Kanne J, Hussong M, Isensee J, Muñoz-López Á, Wolffgramm J, Heß F, Grimm C, Bessonov S, Meder L, Wang J, Reinhardt HC, Odenthal M, Hucho T, Büttner R, Summerer D, Schweiger MR (2021).  Pericentromeric Satellite III transcripts induce etoposide resistance. Cell Death Dis. 2021 May 24;12(6):530. doi: 10.1038/s41419-021-03810-9. PMID: 34031359; PMCID: PMC8144429.
  • McLornan D, Eikema DJ, Czerw T, Kröger N, Koster L, Reinhardt HC, Angelucci E, Robin M, Bornhäuser M, Passweg J, Clark A, Vydra J, Blau IE, Niittyvuopio R, Platzbecker U, Cornelissen JJ, Chevallier P, Srour M, Stamatovic D, Martinez-Lopez J, de Wreede L, Hayden P, Hernández-Boluda JC, Yakoub-Agha I (2021). Trends in allogeneic haematopoietic cell transplantation for myelofibrosis in Europe between 1995 and 2018: a CMWP of EBMT retrospective analysis. Bone Marrow Transplant. 2021 Sep;56(9):2160-2172. doi: 10.1038/s41409-021-01305-x. Epub 2021 Apr 28. PMID: 33911203.
  • Subramaniam N, Bottek J, Thiebes S, Zec K, Kudla M, Soun C, de Dios Panal E, Lill JK, Pfennig A, Herrmann R, Bruderek K, Rahmann S, Brandau S, Johansson P, Reinhardt HC, Dürig J, Seiffert M, Bracht T, Sitek B, Engel DR(2021). Proteomic and bioinformatic profiling of neutrophils in CLL reveals functional defects that predispose to bacterial infections. Blood Adv. 2021 Mar 9;5(5):1259-1272. doi: 10.1182/bloodadvances.2020002949. PMID: 33651101; PMCID: PMC7948268.
  • Reimann M, Schrezenmeier J, Richter-Pechanska P, Dolnik A, Hick TP, Schleich K, Cai X, Fan DNY, Lohneis P, Maßwig S, Denker S, Busse A, Knittel G, Flümann R, Childs D, Childs L, Gätjens-Sanchez AM, Bullinger L, Rosenwald A, Reinhardt HC, Schmitt CA(2021). Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas. Blood. 2021 May 20;137(20):2785-2799. doi: 10.1182/blood.2020005244. PMID: 33232972.
  • Jachimowicz RD, Klapper W, Glehr G, Müller H, Haverkamp H, Thorns C, Hansmann ML, Möller P, Stein H, Rehberg T, von Tresckow B, Reinhardt HC, Borchmann P, Chan FC, Spang R, Scott DW, Engert A, Steidl C, Altenbuchinger M, Rosenwald A (2021). Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP. Leukemia. 2021 Dec;35(12):3589-3593. doi: 10.1038/s41375-021-01314-1. Epub 2021 Jun 10. PMID: 34112956; PMCID: PMC8632672.
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Jane Reznick

  • Reznick J, Park TJ, Lewin GR (2021). A Sweet Story of Metabolic Innovation in the Naked Mole-Rat. Adv Exp Med Biol. 2021;1319:271-286. doi: 10.1007/978-3-030-65943-1_10. PMID: 34424520. 
  • Park TJ, Smith ESJ, Reznick J, Bennett NC, Applegate DT, Larson J, Lewin GR (2021). African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia. Adv Exp Med Biol. . 2021;1319:255-269. doi: 10.1007/978-3-030-65943-1_9. PMID: 34424519.  
  • Lewin GR, Smith ESJ, Reznick J, Debus K, Barker AJ, Park TJ (2021). The Somatosensory World of the African Naked Mole-Rat. Adv Exp Med Biol. 2021;1319:197-220. doi: 10.1007/978-3-030-65943-1_7. PMID: 34424517.

Jan Riemer

  • Peker E, Erdogan AJ, Volkov AN, Riemer J (2021). Erv1 and Cytochrome c Mediate Rapid Electron Transfer via A Collision-Type Interaction. J Mol Biol. 2021 May 8;433(15):167045. doi: 10.1016/j.jmb.2021.167045. Epub ahead of print. PMID: 33971209.
  • Murschall LM, Peker E, MacVicar T, Langer T, Riemer J (2021). Protein Import Assay into Mitochondria Isolated from Human Cells. Bio Protoc. 2021 Jun 20;11(12):e4057. doi: 10.21769/BioProtoc.4057. PMID: 34263000; PMCID: PMC8260258.
  • Schlagowski AM, Knöringer K, Morlot S, Sánchez Vicente A, Flohr T, Krämer L, Boos F, Khalid N, Ahmed S, Schramm J, Murschall LM, Haberkant P, Stein F, Riemer J, Westermann B, Braun RJ, Winklhofer KF, Charvin G, Herrmann JM (2021). Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol.EMBO J. 2021 Aug 16;40(16):e107913. doi: 10.15252/embj.2021107913. Epub 2021 Jun 30. PMID: 34191328; PMCID: PMC8365258.
  • Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Höhne MN, Stüker L, de Pádua Alves C,Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J,George J, Brodesser S, Thomas RK, Reinhardt HC, von Karstedt S (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021 Apr 6;12(1):2048. doi: 10.1038/s41467-021-22336-4. PMID: 33824345; PMCID: PMC8024350.
  • Herrmann, J.M., and Riemer, J. (2021). Apoptosis inducing factor and mitochondrial NADH dehydrogenases: redox-controlled gear boxes to switch between mitochondrial biogenesis and cell death. Biol Chem402, 289-297. 10.1515/hsz-2020-0254.

Elena Rugarli

  • Aravamudhan S, Türk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, König T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E, Trifunovic A, Brüning J, Langer T, Braun T, Krüger M (2021). Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. J Mol Cell Cardiol. 2021 Feb 5;154:41-59.  doi: 10.1016/j.yjmcc.2021.01.010. Online ahead of print.
  • Tadepalle N, Rugarli E (2021).  Lipid Droplets in the Pathogenesis of Hereditary Spastic Paraplegia. Front Mol Biosci. 2021 May 10;8:673977. doi: 10.3389/fmolb.2021.673977. eCollection 2021.

Bernhard Schermer

  • Fabretti F, Tschernoster N, Erger F, Hedergott A, Buescher AK, Dafinger C, Reusch B, Köntges VK, Kohl S, Bartram MP, Weber LT, Thiele H, Altmueller J, Schermer B, Beck BB, Habbig S (2021). Expanding the Spectrum of FAT1 Nephropathies by Novel Mutations That Affect Hippo Signaling. Kidney Int Rep. 2021 Jan 29;6(5):1368-1378. doi: 10.1016/j.ekir.2021.01.023. PMID: 34013115; PMCID: PMC8116753.
  • Hoyer-Allo KJR, Späth MR, Hanssen R, Johnsen M, Brodesser S, Kaufmann K, Kiefer K, Koehler FC, Göbel H, Kubacki T, Grundmann F, Schermer B, Brüning J, Benzing T, Burst V, Müller RU (2021). Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. Int J Mol Sci. 2021 May 22;22(11):5485. doi: 10.3390/ijms22115485. PMID: 34067475; PMCID: PMC8196977. 
  • Butt L, Unnersjö-Jess D, Höhne M, Schermer B, Edwards A, Benzing T (2021). A mathematical estimation of the physical forces driving podocyte detachment. Kidney Int. 2021 Jul 29:S0085-2538(21)00728-6. doi: 10.1016/j.kint.2021.06.040. Epub ahead of print. PMID: 34332959.
  • Mangold N, Pippin J, Unnersjoe-Jess D, Koehler S, Shankland S, Brähler S, Schermer B, Benzing T, Brinkkoetter PT, Hagmann H (2021). The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development. Cells. 2021 Sep 18;10(9):2464. doi: 10.3390/cells10092464. PMID: 34572114.
  • Unnersjö-Jess D, Butt L, Höhne M, Witasp A, Kühne L, Hoyer PF, Patrakka J, Brinkkötter PT, Wernerson A, Schermer B, Benzing T, Scott L, Brismar H, Blom H (2021). A fast and simple clearing and swelling protocol for 3D in-situ imaging of the kidney across scales. Kidney Int. 2021 Apr;99(4):1010-1020. doi: 10.1016/j.kint.2020.10.039. Epub 2020 Dec 5. PMID: 33285146.
  • Talyan S, Filipów S, Ignarski M, Smieszek M, Chen H, Kühne L, Butt L, Göbel H, Hoyer-Allo KJR, Koehler FC, Altmüller J, Brinkkötter P, Schermer B, Benzing T, Kann M, Müller RU, Dieterich C (2021). CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease. Cells. 2021 Mar 20;10(3):692. doi: 10.3390/cells10030692. PMID: 33804736; PMCID: PMC8003990.
  • Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleinerüschkamp F, Oh J, Godefroid N, Eltan M, Güran T, Burtey S, Parotte MC, König J, Braun A, Bos C, Ibars Serra M, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altmüller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF (2021). mTOR-Activating Mutations in <i>RRAGD</i> Are Causative for Kidney Tubulopathy and Cardiomyopathy. J Am Soc Nephrol. 2021 Nov;32(11):2885-2899. doi: 10.1681/ASN.2021030333. Epub 2021 Oct 4. PMID: 34607910.
  • He B, Chen P, Zambrano S, Dabaghie D, Hu Y, Möller-Hackbarth K, Unnersjö-Jess D, Korkut GG, Charrin E, Jeansson M, Bintanel-Morcillo M, Witasp A, Wennberg L, Wernerson A, Schermer B, Benzing T, Ernfors P, Betsholtz C, Lal M, Sandberg R, Patrakka J (2021). Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes. Nat Commun. 2021 Apr 9;12(1):2141. doi: 10.1038/s41467-021-22331-9. PMID: 33837218; PMCID: PMC8035407.
  • Dafinger C, Benzing T, Dötsch J, Schermer B, Liebau MC (2021). Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality. Mol Cell Pediatr. 2021 Feb 12;8(1):1. doi: 10.1186/s40348-021-00111-1. PMID: 33580312; PMCID: PMC7881068.

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Björn Schumacher

  • da Silva PFL, Schumacher B (2021). Principles of the Molecular and Cellular Mechanisms of Aging. J Invest Dermatol. 2021 Jan 28:S0022-202X(20)32364-2. doi: 10.1016/j.jid.2020.11.018. Online ahead of print. PMID: 33518357 
  • Meyer DH, Schumacher B (2021). BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy. Aging Cell. 2021 Mar;20(3):e13320. doi: 10.1111/acel.13320. Epub 2021 Mar 3
  • Schumacher B, Pothof J, Vijg J, Hoeijmakers JHJ (2021). The central role of DNA damage in the ageing process. Nature. 2021 Apr;592(7856):695-703. doi: 10.1038/s41586-021-03307-7. Epub 2021 Apr 28. PMID: 33911272.
  • Ou HL, Schumacher B (2021). Evaluating DNA damage response through immunofluorescence staining of primordial germ cells in Caenorhabditis elegans L1 larva. STAR Protoc. 2021 Apr 5;2(2):100441. doi: 10.1016/j.xpro.2021.100441. PMID: 33899022; PMCID: PMC8056264
  • Rieckher M, Garinis  GA, Schumacher B (2021). Molecular pathology of rare progeroid diseases. Trends Mol Med. 2021 Jul 13;S1471-4914(21)00178-7. doi: 10.1016/j.molmed.2021.06.011. Online ahead of print.
  • Schumacher B, Krieg TM (2021). The Aging Skin: From Basic Mechanisms to Clinical Applications. J Invest Dermatol. 2021 Apr;141(4S):949-950. doi: 10.1016/j.jid.2020.12.002. PMID: 33752815.
  • Dighe, S.G., Chen, J.H., Yan, L., He, Q.C., Gharahkhani, P., Onstad, L., Levine, D.M., Palles, C., Ye, W.M., Gammon, M.D., Iyer, P.G., Anderson, L.A., Liu, G., Wu, A.H., Dai, J.Y., Chow, W.H., Risch, H.A., Lagergren, J., Shaheen, N.J., Bernstein, L., Corley, D.A., Prenen, H., DeCaestecker, J., MacDonald, D., Moayyedi, P., Barr, H., Love, S.B., Chegwidden, L., Attwood, S., Watson, P., Harrison, R., Ott, K., Moebus, S., Venerito, M., Lang, H.K., Mayershofer, R., Knapp, M., Veits, L., Gerges, C., Weismüller, J., Gockel, I., Vashist, Y., Nöthen, M.M., Izbicki, J.R., Manner, H., Neuhaus, H., Rösch, T., Böhmer, A.C., Hölscher, A.H., Anders, M., Pech, O., Schumacher, B., Schmidt, C., Schmidt, T., Noder, T., Lorenz, D., Vieth, M., May, A., Hess, T., Kreuser, N., Becker, J., Ell, C., Ambrosone, C.B., Moysich, K.B., MacGregor, S., Tomlinson, I., Whiteman, D.C., Jankowski, J., Schumacher, J., Vaughan, T.L., Madeleine, M.M., Hardie, L.J., and Buas, M.F. (2021). Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. Carcinogenesis42, 369-377. 10.1093/carcin/bgaa132.

Eline Slagboom

  • Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben-Shlomo Y, Bis JC, Mitchell BD, de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater-Lleal M, Naderi E, Seppälä I, Shah T, Singhal G, Standl M, Teumer A, Thalamuthu A, Thiering E, Trompet S, Ballantyne CM, Benjamin EJ, Casas JP, Toben C, Dedoussis G, Deelen J, Durda P, Engmann J, Feitosa MF, Grallert H, Hammarstedt A, Harris SE, Homuth G, Hottenga JJ, Jalkanen S, Jamshidi Y, Jawahar MC, Jess T, Kivimaki M, Kleber ME, Lahti J, Liu Y, Marques-Vidal P, Mellström D, Mooijaart SP, Müller-Nurasyid M, Penninx B, Revez JA, Rossing P, Räikkönen K, Sattar N, Scharnagl H, Sennblad B, Silveira A, Pourcain BS, Timpson NJ, Trollor J; CHARGE Inflammation Working Group, van Dongen J, Van Heemst D, Visvikis-Siest S, Vollenweider P, Völker U, Waldenberger M, Willemsen G, Zabaneh D, Morris RW, Arnett DK, Baune BT, Boomsma DI, Chang YC, Deary IJ, Deloukas P, Eriksson JG, Evans DM, Ferreira MA, Gaunt T, Gudnason V, Hamsten A, Heinrich J, Hingorani A, Humphries SE, Jukema JW, Koenig W, Kumari M, Kutalik Z, Lawlor DA, Lehtimäki T, März W, Mather KA, Naitza S, Nauck M, Ohlsson C, Price JF, Raitakari O, Rice K, Sachdev PS, Slagboom E, Sørensen TIA, Spector T, Stacey D, Stathopoulou MG, Tanaka T, Wannamethee SG, Whincup P, Rotter JI, Dehghan A, Boerwinkle E, Psaty BM, Snieder H, Alizadeh BZ (2021). Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Hum Mol Genet. 2021 Apr 27;30(5):393-409. doi: 10.1093/hmg/ddab023. PMID: 33517400; PMCID: PMC8098112.
  • van den Akker EB, Makrodimitris S, Hulsman M, Brugman MH, Nikolic T, Bradley T, Waisfisz Q, Baas F, Jakobs ME, de Jong D, Slagboom PE, Staal FJT, Reinders MJT, Holstege H (2021). Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian. Leukemia. 2021 Jul;35(7):2125-2129. doi: 10.1038/s41375-020-01086-0. PMID: 33184493; PMCID: PMC8257492
  • Bacalini MG, Reale A, Malavolta M, Ciccarone F, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Gonos ES, Schön C, Bernhardt J, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Capri M, Hervonen A, Hurme M, Slagboom PE, Breusing N, Aversano V, Tagliatesta S, Franceschi C, Blasco MA, Bürkle A, Caiafa P, Zampieri M (2021). Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study. Geroscience. 2021 Jun;43(3):1283-1302. doi: 10.1007/s11357-021-00347-9. PMID: 33870444; PMCID: PMC8190237.
  • Beenakker KGM, Westendorp RGJ, de Craen AJM, Chen S, Raz Y, Ballieux BEPB, Nelissen RGHH, Later AFL, Huizinga TW, Slagboom PE, Boomsma DI, Maier AB (2022). Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations. J Innate Immun. 2020;12(2):142-153. doi: 10.1159/000499840. PMID: 31230049.
  • Boer CG, Hatzikotoulas K, Southam L, Stefánsdóttir L, Zhang Y, Coutinho de Almeida R, Wu TT, Zheng J, Hartley A, Teder-Laving M, Skogholt AH, Terao C, Zengini E, Alexiadis G, Barysenka A, Bjornsdottir G, Gabrielsen ME, Gilly A, Ingvarsson T, Johnsen MB, Jonsson H, Kloppenburg M, Luetge A, Lund SH, Mägi R, Mangino M, Nelissen RRGHH, Shivakumar M, Steinberg J, Takuwa H, Thomas LF, Tuerlings M; arcOGEN Consortium; HUNT All-In Pain; ARGO Consortium; Regeneron Genetics Center, Babis GC, Cheung JPY, Kang JH, Kraft P, Lietman SA, Samartzis D, Slagboom PE, Stefansson K, Thorsteinsdottir U, Tobias JH, Uitterlinden AG, Winsvold B, Zwart JA, Davey Smith G, Sham PC, Thorleifsson G, Gaunt TR, Morris AP, Valdes AM, Tsezou A, Cheah KSE, Ikegawa S, Hveem K, Esko T, Wilkinson JM, Meulenbelt I, Lee MTM, van Meurs JBJ, Styrkársdóttir U, Zeggini E (2021). Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell. 2021 Sep 2;184(18):4784-4818.e17. doi: 10.1016/j.cell.2021.07.038. Erratum in: Cell. 2021 Nov 24;184(24):6003-6005. PMID: 34450027; PMCID: PMC8459317.
  • van den Berg N, van Dijk IK, Mourits RJ, Slagboom PE, Janssens AAPO, Mandemakers K (2021). Families in comparison: An individual-level comparison of life- course and family reconstructions between population and vital event registers. Popul Stud (Camb). 2021 Mar;75(1):91-110. doi: 10.1080/00324728.2020.1718186. PMID: 32056500.
  • Bos MM, Goulding NJ, Lee MA, Hofman A, Bot M, Pool R, Vijfhuizen LS, Zhang X, Li C, Mustafa R, Neville MJ, Li-Gao R, Trompet S, Beekman M, Biermasz NR, Boomsma DI, de Boer I, Christodoulides C, Dehghan A, van Dijk KW, Ford I, Ghanbari M, Heijmans BT, Ikram MA, Jukema JW, Mook-Kanamori DO, Karpe F, Luik AI, Lumey LH, van den Maagdenberg AMJM, Mooijaart SP, de Mutsert R, Penninx BWJH, Rensen PCN, Richmond RC, Rosendaal FR, Sattar N, Schoevers RA, Slagboom PE, Terwindt GM, Thesing CS, Wade KH, Wijsman CA, Willemsen G, Zwinderman AH, van Heemst D, Noordam R, Lawlor DA (2021). Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses. BMC Med. 2021 Mar 18;19(1):69. doi: 10.1186/s12916-021-01939-0. PMID: 33731105;PMCID: PMC7971964.
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  • van Vliet NA, van Heemst D, Almeida OP, Åsvold BO, Aubert CE, Bae JB, Barnes LE, Bauer DC, Blauw GJ, Brayne C, Cappola AR, Ceresini G, Comijs HC, Dartigues JF, Degryse JM, Dullaart RPF, van Eersel MEA, den Elzen WPJ, Ferrucci L, Fink HA, Flicker L, Grabe HJ, Han JW, Helmer C, Huisman M, Ikram MA, Imaizumi M, de Jongh RT, Jukema JW, Kim KW, Kuller LH, Lopez OL, Mooijaart SP, Moon JH, Moutzouri E, Nauck M, Parle J, Peeters RP, Samuels MH, Schmidt CO, Schminke U, Slagboom PE, Stordal E, Vaes B, Völzke H, Westendorp RGJ, Yamada M, Yeap BB, Rodondi N, Gussekloo J, Trompet S; Thyroid Studies Collaboration (2021). Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis. JAMA Intern Med. 2021 Nov 1;181(11):1440-1450. doi: 10.1001/jamainternmed.2021.5078. PMID: 34491268; PMCID: PMC8424529.
  • Võsa U, Claringbould A, Westra HJ, Bonder MJ, Deelen P, Zeng B, Kirsten H, Saha A, Kreuzhuber R, Yazar S, Brugge H, Oelen R, de Vries DH, van der Wijst MGP, Kasela S, Pervjakova N, Alves I, Favé MJ, Agbessi M, Christiansen MW, Jansen R, Seppälä I, Tong L, Teumer A, Schramm K, Hemani G, Verlouw J, Yaghootkar H, Sönmez Flitman R, Brown A, Kukushkina V, Kalnapenkis A, Rüeger S, Porcu E, Kronberg J, Kettunen J, Lee B, Zhang F, Qi T, Hernandez JA, Arindrarto W, Beutner F; BIOS Consortium; i2QTL Consortium, Dmitrieva J, Elansary M, Fairfax BP, Georges M, Heijmans BT, Hewitt AW, Kähönen M, Kim Y, Knight JC, Kovacs P, Krohn K, Li S, Loeffler M, Marigorta UM, Mei H, Momozawa Y, Müller- Nurasyid M, Nauck M, Nivard MG, Penninx BWJH, Pritchard JK, Raitakari OT, Rotzschke O, Slagboom EP, Stehouwer CDA, Stumvoll M, Sullivan P, 't Hoen PAC, Thiery J, Tönjes A, van Dongen J, van Iterson M, Veldink JH, Völker U, Warmerdam R, Wijmenga C, Swertz M, Andiappan A, Montgomery GW, Ripatti S, Perola M, Kutalik Z, Dermitzakis E, Bergmann S, Frayling T, van Meurs J, Prokisch H, Ahsan H, Pierce BL, Lehtimäki T, Boomsma DI, Psaty BM, Gharib SA, Awadalla P, Milani L, Ouwehand WH, Downes K, Stegle O, Battle A, Visscher PM, Yang J, Scholz M, Powell J, Gibson G, Esko T, Franke L (2021). Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat Genet. 2021 Sep;53(9):1300-1310. doi: 10.1038/s41588-021-00913-z. PMID: 34475573; PMCID: PMC8432599.
  • Wang W, van Dijk KW, Wijsman CA, Rozing MP, Mooijaart SP, Beekman M, Slagboom PE, Jukema JW, Noordam R, van Heemst D (2021). Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study. Metabolomics. 2021 Jun 9;17(6):57. doi: 10.1007/s11306-021-01806-2. PMID: 34106350; PMCID: PMC8190027.

Alessandra Stangherlin 

  • Hayter, E.A., Wehrens, S.M.T., Van Dongen, H.P.A., Stangherlin, A., Gaddameedhi, S., Crooks, E., Barron, N.J., Venetucci, L.A., O'Neill, J.S., Brown, T.M., Skene, D.J., Trafford, A.W., and Bechtold, D.A. (2021). Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia. Nat Commun12, 2472. 10.1038/s41467-021-22788-8.
  • Kay, H., Grunewald, E., Feord, H.K., Gil, S., Peak-Chew, S.Y., Stangherlin, A., O'Neill, J.S., and van Ooijen, G. (2021). Deep-coverage spatiotemporal proteome of the picoeukaryote Ostreococcus tauri reveals differential effects of environmental and endogenous 24-hour rhythms. Commun Biol4, 1147. 10.1038/s42003-021-02680-3.
  • Ray, S., Valekunja, U.K., Stangherlin, A., Howell, S.A., Snijders, A.P., Damodaran, G., and Reddy, A.B. (2021). Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1". Science372. 10.1126/science.abf1941.
  • Ray, S., Valekunja, U.K., Stangherlin, A., Howell, S.A., Snijders, A.P., Damodaran, G., and Reddy, A.B. (2021). Erratum for the Report Circadian rhythms in the absence of the clock gene Bmal1. (vol 367, pg 800, 2020). Science371. ARTN eabg5409. 10.1126/science.abg5409.
  • Stangherlin, A., Day, J., and O'Neill, J. (2021). Inductively Coupled Plasma Mass Spectrometry for Elemental Analysis in Circadian Biology. Methods Mol Biol2130, 19-27. 10.1007/978-1-0716-0381-9_2.
  • Stangherlin, A., Seinkmane, E., and O'Neill, J.S. (2021). Understanding circadian regulation of mammalian cell function, protein homeostasis, and metabolism. Curr Opin Syst Biol28, None. 10.1016/j.coisb.2021.100391.
  • Stangherlin, A., Watson, J.L., Wong, D.C.S., Barbiero, S., Zeng, A., Seinkmane, E., Chew, S.P., Beale, A.D., Hayter, E.A., Guna, A., Inglis, A.J., Putker, M., Bartolami, E., Matile, S., Lequeux, N., Pons, T., Day, J., van Ooijen, G., Voorhees, R.M., Bechtold, D.A., Derivery, E., Edgar, R.S., Newham, P., and O'Neill, J.S. (2021). Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology. Nat Commun12, 6035. 10.1038/s41467-021-25942-4.

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Sophie Steculorum

  • Gouveia A, de Oliveira Beleza R, Steculorum SM (2021). AgRP neuronal activity across feeding-related behaviours. Eur J Neurosci. 2021 Oct 16. doi: 10.1111/ejn.15498. Online ahead of print.PMID: 34655481.
  • Pujol C, Legrand A, Parodi L, Thomas P, Mochel F, Saracino D, Coarelli G, Croon M, Popovic M, Valet M, Villain N, Elshafie S, Issa M, Zuily S, Renaud M, Marelli-Tosi C, Legendre M, Trimouille A, Kemlin I, Mathieu S, Gleeson JG, Lamari F, Galatolo D, Alkouri R, Tse C, Rodriguez D, Ewenczyk C, Fellmann F, Kuntzer T, Blond E, El Hachimi KH, Darios F, Seyer A, Gazi AD, Giavalisco P, Perin S, Boucher JL, Le Corre L, Santorelli FM, Goizet C, Zaki MS, Picaud S, Mourier A, Steculorum SM, Mignot C, Durr A, Trifunovic A, Stevanin G. Implication of folate deficiency in CYP2U1 loss of function.J Exp Med. (2021) Nov 1;218(11):e20210846. doi: 10.1084/jem.20210846. Epub 2021 Sep 21.PMID: 34546337

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Philipp Steven

  • Gehlsen U, Stary D, Maass M, Riesner K, Musial G, Stern ME, Penack O, Steven P(2021). Ocular Graft-versus-Host Disease in a Chemotherapy-Based Minor-Mismatch Mouse Model Features Corneal (Lymph-) Angiogenesis. Int J Mol Sci. 2021 Jun 8;22(12):6191. doi: 10.3390/ijms22126191. PMID: 34201218; PMCID: PMC8228997.
  • Wolff D, Radojcic V, Lafyatis R, Cinar R, Rosenstein RK, Cowen EW, Cheng GS, Sheshadri A, Bergeron A, Williams KM, Todd JL, Teshima T, Cuvelier GDE, Holler E, McCurdy SR, Jenq RR, Hanash AM, Jacobsohn D, Santomasso BD, Jain S, Ogawa Y, Steven P, Luo ZK, Dietrich-Ntoukas T, Saban D, Bilic E, Penack O, Griffith LM, Cowden M, Martin PJ, Greinix HT, Sarantopoulos S, Socie G, Blazar BR, Pidala J, Kitko CL, Couriel DR, Cutler C, Schultz KR, Pavletic SZ, Lee SJ, Paczesny S (2021). National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report. Transplant Cell Ther. 2021 Oct;27(10):817-835. doi: 10.1016/j.jtct.2021.06.001. Epub 2021 Jun 10. PMID: 34217703; PMCID: PMC8478861.
  • Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C (2021). National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. Transplant Cell Ther. 2021 Jul;27(7):545-557. doi: 10.1016/j.jtct.2021.03.033. Epub 2021 Apr 9. PMID: 33839317; PMCID: PMC8803210.
  • Setu MAK, Horstmann J, Schmidt S, Stern ME, Steven P (2021). Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography. Sci Rep. 2021 Apr 7;11(1):7649. doi: 10.1038/s41598-021-87314-8. PMID: 33828177; PMCID: PMC8027879.
  • Appenteng Osae E, Steven P (2021). Meibomian Gland Dysfunction in Ocular Graft vs. Host Disease: A Need for Pre-Clinical Models and Deeper Insights. Int J Mol Sci. 2021 Mar 29;22(7):3516. doi: 10.3390/ijms22073516. PMID: 33805326; PMCID: PMC8036656.
  • Pinto-Fraga J, Calonge M, Enríquez-de-Salamanca A, Fernández I, González-García MJ, Steven P (2021). Development of a Questionnaire for Detecting Changes in Dry Eye Disease-Related Symptoms. Eye Contact Lens. 2021 Jan 1;47(1):8-14. doi: 10.1097/ICL.0000000000000693. PMID: 32097186.
  • Gehlsen U, Siebelmann S, Steven P (2021). Tolerance and Adherence to Cationic 0.1% Cyclosporine in Ocular Graft-versus-Host Disease. Ophthalmic Res. 2021;64(1):77-84. doi: 10.1159/000509034. Epub 2020 May 29. PMID: 32474565.
  • Tahmaz V, Wiesen MHJ, Gehlsen U, Sauerbier L, Stern ME, Holtick U, Gathof B, Scheid C, Müller C, Steven P (2021). Detection of systemic immunosuppressants in autologous serum eye drops (ASED) in patients with severe chronic ocular graft versus host disease. Graefes Arch Clin Exp Ophthalmol. 2021 Jan;259(1):121-128. doi: 10.1007/s00417-020-04865-8. Epub 2020 Aug 19. PMID: 32812133; PMCID: PMC7790777.
  • Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. Transpl Cell Ther27, 545-557. 10.1016/j.jtct.2021.03.033.
  • Osae, E.A., and Steven, P. (2021). Meibomian Gland Dysfunction in Ocular Graft vs. Host Disease: A Need for Pre-Clinical Models and Deeper Insights. International Journal of Molecular Sciences22. ARTN 3516. 10.3390/ijms22073516.
  • Setu, M.A.K., Schmidt, S., Musial, G., Tahmaz, V., Stern, M.E., and Steven, P. (2021). Deep Learning-based Segmentation and Quantification of Nerve Fibers and Dendritic cells in Confocal Microscopy of the Cornea. Invest Ophth Vis Sci62.
  • Steven, P., Maass, M., Hess, D., Tahmaz, V., Holtick, U., Scheid, C., De Paiva, C.S., Stern, M.E., and Gehlsen, U. (2021). Adverse Environmental Stress is a Risk Factor for Ocular Graft-Versus-Host Disease. Invest Ophth Vis Sci62.
  • Tran, B.N., Maass, M., Horstmann, J., Musial, G., Stern, M.E., Gehlsen, U., and Steven, P. (2021). Efficacy of topical application of cannabinoid receptor ligands in experimental dry eye disease. Invest Ophth Vis Sci62.

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Peter Tessarz

  • Pouikli A, Tessarz P (2021). Metabolism and chromatin: A dynamic duo that regulates development and ageing: Elucidating the metabolism-chromatin axis in bone-marrow mesenchymal stem cell fate decisions. Bioessays. 2021 Feb 25:e2000273. doi: 10.1002/bies.202000273. Online ahead of print. PMID: 33629755 
  • Allmeroth K, Kim CS, Annibal A, Pouikli A, Koester J, Derisbourg MJ, Andrés Chacón-Martínez C, Latza C, Antebi A,Tessarz P, Wickström SA, Denzel MS. N1-acetylspermidine is a determinant of hair follicle stem cell fate. J Cell Sci. 2021 May 1;134(9):jcs252767. doi: 10.1242/jcs.252767. Epub 2021 May 11. PMID: 33973637. 
  • Kochan DZ, Mawer JSP, Massen J, Tishinov K, Parekh S, Graef M, Spang A, Tessarz P (2021). The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription. J Cell Sci. 2021 Jul 14:jcs.259051. doi: 10.1242/jcs.259051. Epub ahead of print. PMID: 34259327.
  • Mawer JSP, Massen J, Reichert C, Grabenhorst N, Mylonas C, Tessarz P (2021). Nhp2 is a reader of H2AQ105me and part of a network integrating metabolism with rRNA synthesis. EMBO Rep. 2021 Aug 19:e52435. doi: 10.15252/embr.202152435. Epub ahead of print. PMID: 34409714. 
  • Theobald SJ, Simonis A, Georgomanolis T, Kreer C, Zehner M, Eisfeld HS, Albert MC, Chhen J, Motameny S, Erger F, Fischer J, Malin JJ, Gräb J, Winter S, Pouikli A, David F, Böll B, Koehler P, Vanshylla K, Gruell H, Suárez I, Hallek M, Fätkenheuer G, Jung N, Cornely OA, Lehmann C, Tessarz P, Altmüller J, Nürnberg P, Kashkar H, Klein F, Koch M, Rybniker J (2021). Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med. 2021 Aug 9;13(8):e14150. doi: 10.15252/emmm.202114150. Epub 2021 Jun 16. PMID: 34133077; PMCID: PMC8350892.
  • Pouikli A, Parekh S, Maleszewska M, Baghdadi M, Tripodi I, Nikopoulou C, Folz-Donahue K, Hinze Y, Mesaros A, Giavalisco P, Dowell R, Partridge L, Tessarz P (2021): Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature Aging 1, 810–825
  • Nikopoulou C, Kleinenkuhnen N, Parekh S, Schneider F, Bozukova M, Vesting AJ, Altmüller J, Wunderlich T, Kondylis V, Tresch A, Tessarz P (2021). Single cell resolution unravels spatial alterations in metabolism, transcriptome and epigenome of ageing liver. bioRxiv. Doi: 10.1101/2021.11.14.472593

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Marc Tittgemeyer

  • Ruppert MC, Greuel A, Freigang J, Tahmasian M, Maier F, Hammes J, van Eimeren T, Timmermann L, Tittgemeyer M, Drzezga A, Eggers C (2021).  The default mode network and cognition in Parkinson's disease: A multimodal resting-state network approach. Hum Brain Mapp. 2021 Feb 27. doi: 10.1002/hbm.25393. Online ahead of print. PMID: 33638213
  • Schöbi D, Homberg F, Frässle S, Endepols H, Moran RJ, Friston KJ, Tittgemeyer M, Heinzle J, Stephan KE. Model-based prediction of muscarinic receptor function from auditory mismatch negativity responses. Neuroimage. 2021 Apr 30:118096. doi: 10.1016/j.neuroimage.2021.118096. Epub ahead of print. PMID: 33940149.
  • Borgmann D, Ciglieri E, Biglari N, Brandt C, Cremer AL, Backes H, Tittgemeyer M, Wunderlich FT, Brüning JC, Fenselau H (2021). Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab. 2021 May 21:S1550-4131(21)00219-9. doi: 10.1016/j.cmet.2021.05.002. Epub ahead of print. PMID: 34043943. 
  • Loehrer PA, Nettersheim FS, Oehrn CR, Homberg F, Tittgemeyer M, Timmermann L, Weber I (2021). Increased prefrontal top-down control in older adults predicts motor performance and age-group association. Neuroimage. 2021 Jul 10;240:118383. doi: 10.1016/j.neuroimage.2021.118383. Epub ahead of print. PMID: 34252525.
  • Alicart H, Heldmann M, Göttlich M, Obst MA, Tittgemeyer M, Münte TF (2021). Modulation of visual processing of food by transcutaneous vagus nerve stimulation (tVNS). Brain Imaging Behav. 2021 Aug;15(4):1886-1897. doi: 10.1007/s11682-020-00382-8. PMID: 32926315
  • Borgmann D, Rigoux L, Kuzmanovic B, Edwin Thanarajah S, Münte TF, Fenselau H, Tittgemeyer M (2021). Technical Note: Modulation of fMRI brainstem responses by transcutaneous vagus nerve stimulation. Neuroimage. 2021 Sep 10; 244:118566. doi: 10.1016/j.neuroimage.2021.118566. Online ahead of print. PMID: 34509623
  • Hanssen, R, Kretschmer AC, Rigoux L, Albus K, Edwin Thanarajah S, Sitnikow T, Melzer C, Cornely OA, Brüning JC, Tittgemeyer M (2021). GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans. Mol Metab. 2021 Mar;45:101163. doi: 10.1016/j.molmet.2021.101163. Epub 2021 Jan 14. PMID: 33453418
  • Steidel K, Ruppert MC, Palaghia I, Greuel A, Tahmasian M, Maier F, Hammes J, van Eimeren T, Timmermann L, Tittgemeyer M, Drzezga A, Pedrosa D, Eggers C (2021). Dopaminergic pathways and resting-state functional connectivity in Parkinson's disease with freezing of gait. Neuroimage Clin. 2021;32:102899. doi: 10.1016/j.nicl.2021.102899. Epub 2021 Nov 29. PMID: 34911202; PMCID: PMC8645514.
  • Schöbi, D., Homberg, F., Frässle, S., Endepols, H., Moran, R.J., Friston, K.J., Tittgemeyer, M., Heinzle, J., and Stephan, K.E. (2021). Model-based prediction of muscarinic receptor function from auditory mismatch negativity responses. Neuroimage237. ARTN 118096. 10.1016/j.neuroimage.2021.118096.

Achim Tresch

  • Failmezger H, Zwing N, Tresch A, Korski K, Schmich F (2021). Computational Tumor Infiltration Phenotypes Enable the Spatial and Genomic Analysis of Immune Infiltration in Colorectal Cancer. Front Oncol. 2021 Mar 15;11:552331. doi: 10.3389/fonc.2021.552331. PMID: 33791196; PMCID: PMC8006941.
  • Schlusche AK, Vay SU, Kleinenkuhnen N, Sandke S, Campos-Martín R, Florio M, Huttner W, Tresch A, Roeper J, Rueger MA, Jakovcevski I, Stockebrand M, Isbrandt D (2021). Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice. Proc Natl Acad Sci U S A.2021 Aug 31;118(35):e2009393118. doi: 10.1073/pnas.2009393118. PMID: 34429357; PMCID: PMC8536352.
  • Werner DJ, Baar T, Kiesslich R, Wenzel N, AbusalimN, Tresch A, Rey JW (2021). Endoscopic hemostasis makes the difference: Angiographic treatment in patients with lower gastrointestinal bleeding. World J Gastrointest Endosc. 2021 Jul 16;13(7):221-232. doi: 10.4253/wjge.v13.i7.221. PMID: 34326943; PMCID: PMC8311471.

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Aleksandra Trifunovic

  • Hofsetz E, Huesgen PF, Trifunovic A (2021). Identification of Putative Mitochondrial Protease Substrates. Methods Mol Biol. 2021;2192:313-329. doi: 10.1007/978-1-0716-0834-0_21. PMID: 33230781 
  • Szczepanowska K, Trifunovic A (2021). Tune instead of destroy: How proteolysis keeps OXPHOS in shape. Biochim Biophys Acta Bioenerg. 2021 Jan 5:148365. doi: 10.1016/j.bbabio.2020.148365. Online ahead of print. PMID: 33417924 Review 
  • Aravamudhan S, Türk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, König T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E, Trifunovic A, Brüning J, Langer T, Braun T, Krüger M (2021). Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. J Mol Cell Cardiol. 2021 Feb 4:S0022-2828(21)00025-0.PMID: 33549681
  • Silva-Pinheiro P, Pardo-Hernández C, Reyes A, Tilokani L, Mishra A, Cerutti R, Li S, Rozsivalova DH, Valenzuela S, Dogan SA, Peter B, Fernández-Silva P, Trifunovic A, Prudent J, Minczuk M, Bindoff L, Macao B, Zeviani M, Falkenberg M, Viscomi C. DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion. Nucleic Acids Res. 2021 May 6:gkab282. doi: 10.1093/nar/gkab282. Epub ahead of print. PMID: 33956154. 
  • Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A (2021). Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv. 2021 May 26;7(22):eabf0971. doi: 10.1126/sciadv.abf0971. PMID: 34039602. 
  • Bock T, Türk C, Aravamudhan S, Keufgens L, Bloch W, Rozsivalova DH, Romanello V, Nogara L, Blaauw B, Trifunovic A, Braun T, Krüger M (2021). PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B. Nat Commun. 2021 Aug 12;12(1):4900. doi: 10.1038/s41467-021-25185-3. PMID: 34385433; PMCID: PMC8361071.
  • Calculli, G., Lee, H.J., Shen, K.N., Pham, U., Herholz, M., Trifunovic, A., Dillin, A., and Vilchez, D. (2021). Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of. Sci Adv7. ARTN eabg3012. 10.1126/sciadv.abg3012.
  • Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M (2021). Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress. Mol Cell. 2021 Oct 21;81(20):4191-4208.e8. doi: 10.1016/j.molcel.2021.09.029. PMID: 34686314
  • Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021 Oct 25:S1550-4131(21)00482-4. doi: 10.1016/j.cmet.2021.10.004. Online ahead of print. PMID: 34715039
  • Pujol C, Legrand A, Parodi L, Thomas P, Mochel F, Saracino D, Coarelli G, Croon M, Popovic M, Valet M, Villain N, Elshafie S, Issa M, Zuily S, Renaud M, Marelli-Tosi C, Legendre M, Trimouille A, Kemlin I, Mathieu S, Gleeson JG, Lamari F, Galatolo D, Alkouri R, Tse C, Rodriguez D, Ewenczyk C, Fellmann F, Kuntzer T, Blond E, El Hachimi KH, Darios F, Seyer A, Gazi AD, Giavalisco P, Perin S, Boucher JL, Le Corre L, Santorelli FM, Goizet C, Zaki MS, Picaud S, Mourier A, Steculorum SM, Mignot C, Durr A, Trifunovic A, Stevanin G(2021). Implication of folate deficiency in CYP2U1 loss of function. J Exp Med. 2021 Nov 1;218(11):e20210846. doi: 10.1084/jem.20210846. Epub 2021 Sep 21. PMID: 34546337; PMCID: PMC8480666.
  • Dinić M, Herholz M, Kačarević U, Radojević D, Novović K, Đokić J, Trifunović A, Golić N. (2021) Host-commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy. Aging (Albany NY). 2021 Mar 26;13(6):8040-8054. doi: 10.18632/aging.202885. Epub 2021 Mar 26. PMID: 33770762; PMCID: PMC8034897.

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Achim Tresch

  • Failmezger H, Zwing N, Tresch A, Korski K, Schmich F. Computational Tumor Infiltration Phenotypes Enable the Spatial and Genomic Analysis of Immune Infiltration in Colorectal Cancer. Front Oncol. 2021 Mar 15;11:552331. doi: 10.3389/fonc.2021.552331. PMID: 33791196; PMCID: PMC8006941.
  • Schlusche AK, Vay SU, Kleinenkuhnen N, Sandke S, Campos-Martín R, Florio M, Huttner W, Tresch A, Roeper J, Rueger MA, Jakovcevski I, Stockebrand M, Isbrandt D (2021). Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice. Proc Natl Acad Sci U S A.2021 Aug 31;118(35):e2009393118. doi: 10.1073/pnas.2009393118. PMID: 34429357; PMCID: PMC8536352.
  • Werner DJ, Baar T, Kiesslich R, Wenzel N, AbusalimN, Tresch A, Rey JW (2021). Endoscopic hemostasis makes the difference: Angiographic treatment in patients with lower gastrointestinal bleeding. World J Gastrointest Endosc. 2021 Jul 16;13(7):221-232. doi: 10.4253/wjge.v13.i7.221. PMID: 34326943; PMCID: PMC8311471.

Mirka Uhlirova

  • Erkelenz S, Stankovic D, Mundorf J, Bresser T, Claudius A-K, Boehm V, Gehring NH, Uhlirova M (2021). Ecd promotes U5 snRNP maturation and Prp8 stability. Nucleic Acids Res. gkaa1274

Dario Valenzano

  • Cui R, Tyers AM, Malubhoy ZJ, Wisotsky S, Valdesalici S, Henriette E, Kosakovsky Pond SL, Valenzano DR(2021). Ancestral transoceanic colonization and recent population reduction in a non-annual killifish from the Seychelles archipelago. Mol Ecol. 2021 May 16. doi: 10.1111/mec.15982. Epub ahead of print. PMID: 33998095.
  • Khallaf MA, Cui R, Weißflog J, Erdogmus M, Svatoš A, Dweck HKM, Valenzano DR, Hansson BS, Knaden M. Large-scale characterization of sex pheromone communication systems in Drosophila. Nat Commun. 2021 Jul 6;12(1):4165. doi: 10.1038/s41467-021-24395-z. PMID: 34230464.

David Vilchez

  • Llamas E, Torres-Montilla S, Lee HJ, Barja MV, Schlimgen E, Dunken N, Wagle P, Werr W, Zuccaro A, Rodríguez-Concepción M, Vilchez D (2021). The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress. Aging Cell. 2021 Aug;20(8):e13446. doi: 10.1111/acel.13446. Epub ahead of print Jul 30.PMID: 34327811; PMCID: PMC8373342
  • Koyuncu S, Loureiro R, Lee HJ, Wagle P,Krueger M, Vilchez D(2021). Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Nature. 2021 Aug;596(7871):285-290. doi: 10.1038/s41586-021-03781-z. Epub 2021 Jul 28. PMID: 34321666; PMCID: PMC8357631.
  • Calculli, G., Lee, H.J., Shen, K.N., Pham, U., Herholz, M., Trifunovic, A., Dillin, A., and Vilchez, D. (2021). Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of. Sci Adv7. ARTN eabg3012. 10.1126/sciadv.abg3012.
  • Sarroca, S., Gatius, A., Rodríguez-Farré, E., Vilchez, D., Pallàs, M., Griñán-Ferré, C., Sanfeliu, C., and Corpas, R. (2021). Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms. J Nutr Biochem89. 10.1016/j.jnutbio.2020.108569.

Silvia von Karstedt

  • Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Höhne MN, Stüker L, de Pádua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J,  George J, Brodesser S, Thomas RK, Reinhardt C, von Karstedt S (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021 Apr 6;12(1):2048. doi: 10.1038/s41467-021-22336-4 
  • Willms A, Schupp H, Poelker M, Adawy A, Debus JF, Hartwig T, Krichel T, Fritsch J, Singh S, Walczak H, von Karstedt S, Schäfer H, Trauzold A (2021). TRAIL-receptor 2-a novel negative regulator of p53. Cell Death Dis. 2021 Jul 31;12(8):757. doi: 10.1038/s41419-021-04048-1. PMID: 34333527.
  • Brägelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, Lohneis P, Gu J, Godfrey LK, Forster J, Trajkovic-Arsic M, Zillinger T, Haarmann M, Quaas A, Lennartz S, Schmiel M, D'Rozario J, Thomas ES, Li H, Schmitt CA, George J, Thomas RK, von Karstedt S, Hartmann G, Büttner R, Ullrich RT, Siveke JT, Ohashi K, Schlee M, Sos ML (2021). MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Nat Commun. 2021 Sep 17;12(1):5505. doi: 10.1038/s41467-021-25728-8. PMID: 34535668
  • Bebber CM, von Karstedt S (2021). Non-neuroendocrine differentiation generates a ferroptosis-prone lipidome in small cell lung cancer (SCLC). Mol Cell Oncol. 2021 Jul 5;8(4):1933871. doi: 10.1080/23723556.2021.1933871. eCollection 2021. PMID: 34616869
  • von Karstedt, S., and Walczak, H. (2020). An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer. Cell Death Discovery6. ARTN 14. 10.1038/s41420-020-0249-4.
  • Pedrera, L., Espiritu, R.A., Ros, U., Weber, J., Schmitt, A., Stroh, J., Hailfinger, S., von Karstedt, S., and Garcia-Saez, A.J. (2021). Ferroptotic pores induce Ca(2+) fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ28, 1644-1657. 10.1038/s41418-020-00691-x.

Johannes Vogt

  • Ye L, Ji H, Liu J, Tu CH, Kappl M, Koynov K, Vogt J*#, Butt HJ (2021). Carbon Nanotube-Hydrogel Composites Facilitate Neuronal Differentiation While Maintaining Homeostasis of Network Activity. Adv Mater. 2021 Aug 27:e2102981. doi: 10.1002/adma.202102981. Online ahead of print. PMID: 34453367
  • Fischer C, Endle H, Schumann L, Wilken-Schmitz A, Kaiser J, Gerber S, Vogelaar CF, Schmidt MHH, Nitsch R, Snodgrass I, Thomas D, Vogt J*, Tegeder I*(2021). Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2. Cell Mol Life Sci. 2021 Feb;78(3):1029-1050. doi: 10.1007/s00018-020-03553-4. Epub 2020 May 28.
  • Iwama T, Kano K, Saigusa D, Ekroos K, van Echten-Deckert G, Vogt J, Aoki J(2021). Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag. Anal Chem. 2021 Mar 2;93(8):3867-3875. doi: 10.1021/acs.analchem.0c04479. Epub 2021 Feb 12. PMID: 33577289
  • Le Provost, G., Thiele, J., Westphal, C., Penone, C., Allan, E., Neyret, M., van der Plas, F., Ayasse, M., Bardgett, R.D., Birkhofer, K., Boch, S., Bonkowski, M., Buscot, F., Feldhaar, H., Gaulton, R., Goldmann, K., Gossner, M.M., Klaus, V.H., Kleinebecker, T., Krauss, J., Renner, S., Scherreiks, P., Sikorski, J., Baulechner, D., Blüthgen, N., Bolliger, R., Börschig, C., Busch, V., Chisté, M., Fiore-Donno, A.M., Fischer, M., Arndt, H., Hoelzel, N., John, K., Jung, K., Lange, M., Marzini, C., Overmann, J., Pasalic, E., Perovic, D.J., Prati, D., Schäfer, D., Schöning, I., Schrumpf, M., Sonnemann, I., Steffan-Dewenter, I., Tschapka, M., Türke, M., Vogt, J., Wehner, K., Weiner, C., Weisser, W., Wells, K., Werner, M., Wolters, V., Wubet, T., Wurst, S., Zaitsev, A.S., and Manning, P. (2021). Contrasting responses of above- and belowground diversity to multiple components of land-use intensity. Nat Commun12. ARTN 3918. 10.1038/s41467-021-23931-1.

Henning Walczak

  • Willms A, Schupp H, Poelker M, Adawy A, Debus JF, Hartwig T, Krichel T, Fritsch J, Singh S, Walczak H, von Karstedt S, Schäfer H, Trauzold A (2021). TRAIL-receptor 2-a novel negative regulator of p53. Cell Death Dis.2021 Jul 31;12(8):757. doi: 10.1038/s41419-021-04048-1. PMID: 34333527.
  • Jain R, Zhao K, Sheridan JM, Heinlein M, Kupresanin F, Abeysekera W, Hall C, Rickard J, Bouillet P, Walczak H, Strasser A, Silke J, Gray DHD (2021). Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell Death Differ. 2021 Oct;28(10):2946-2956. doi: 10.1038/s41418-021-00850-8. Epub. 2021 Aug 11. PMID: 34381167; PMCID: PMC8481470.
  • Bolik, J., Krause, F., Stevanovic, M., Gandrass, M., Thomsen, I., Schacht, S.S., Rieser, E., Mueller, M., Schumacher, N., Fritsch, J., Wichert, R., Galun, E., Bergmann, J., Roeder, C., Schafmayer, C., Egberts, J.H., Becker-Pauly, C., Saftig, P., Lucius, R., Schneider-Brachert, W., Barikbin, R., Adam, D., Voss, M., Hitzl, W., Krueger, A., Strilic, B., Sagi, I., Walczak, H., Rose-John, S., and Schmidt-Arras, D. (2021). Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis. Journal of Experimental Medicine219. ARTN e20201039. 10.1084/jem.20201039.

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Sara Wickström

  • Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Gröne HJ, Graumann PL, Niessen CM, Offermanns S, Wickström SA, Worzfeld T (2021). Mechanochemical control of epidermal stem cell divisions by B-plexins. Nat Commun. 2021 Feb 26;12(1):1308. doi: 10.1038/s41467-021-21513-9. PMID: 33637728
  • Allmeroth K, Kim CS, Annibal A, Pouikli A, Koester J, Derisbourg MJ, Andrés Chacón-Martínez C, Latza C, Antebi A, Tessarz P, Wickström SA, Denzel MS (2021). N1-acetylspermidine is a determinant of hair follicle stem cell fate. J Cell Sci. 2021 May 1;134(9):jcs252767. doi: 10.1242/jcs.252767. Epub 2021 May 11. PMID: 33973637.
  • Tayem R, Niemann C, Pesch M, Morgner J, Niessen CM, Wickström SA, Aumailley M (2021). LAMININ 332 IS INDISPENSABLE FOR HOMEOSTATIC EPIDERMAL DIFFERENTIATION PROGRAMS. J Invest Dermatol. 2021 May 6:S0022-202X(21)01215-X. doi: 10.1016/j.jid.2021.04.008. Epub ahead of print. PMID: 33965403. 
  • Koester J, Miroshnikova YA, Ghatak S, Chacón-Martínez CA, Morgner J, Li X, Atanassov I, Altmüller J, Birk DE, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, Wickström SA (2021). Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nat Cell Biol. 2021 Jul;23(7):771-781. doi: 10.1038/s41556-021-00705-x. Epub 2021 Jul 8. PMID: 34239060. 
  • Maki K, Nava MM, Villeneuve C, Chang M, Furukawa KS, Ushida T, Wickström SA (2021). Hydrostatic pressure prevents chondrocyte differentiation through heterochromatin remodeling. J Cell Sci. 2021 Jan 15;134(2):jcs247643. doi: 10.1242/jcs.247643. Epub 2021 Jan 27. PMID: 34432033.
  • Peters F, Wickström SA(2021). What doesn't kill you makes you differentiate. Dev Cell. 2021 Dec 20;56(24):3303-3304. doi: 10.1016/j.devcel.2021.12.002. PMID: 34932945.
  • Trela E, Lan Q, Myllymäki S, Villeneuve C, Lindström R, Kumar V, Wickström SA, Mikkola ML (2021). Cell influx and contractile actomyosin force drive mammary bud growth and invagination. J Cell Biol. Aug 2;220(8):e202008062. doi: 10.1083/jcb.202008062. Epub 2021 May 27. PMID: 34042944
  • Miroshnikova YA, Manet S, Li X, Wickström SA, Faurobert E, Albiges-Rizo C (2021). Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch. Mol Biol Cell. Aug 19;32(18):1724-1736. doi: 10.1091/mbc.E21-03-0106. Epub 2021 Jun 3. PMID: 34081532
  • Wickström, S.A. (2021). Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nature Cell Biology 23, 771-+. 10.1038/s41556-021-00705-x.
  • Sawant, M., Wang, F., Koester, J., Nava, M., Wickström, S., Eckes, B., and Krieg, T. (2021). Collagen-binding integrins are important for orchestrating tissue architecture and fibrotic responses. J Invest Dermatol141, S209-S209.

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Rudolf J. Wiesner

  • Kimoloi S, Pla-Martín D, Oexner RR, Baris OR, Wiesner RJ (2021). Author Response: K320E-Twinkleskm Mice Are Genetically Heterogeneous for Secondary mtDNA Deletions Impairing Comparison With Controls. Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):13. doi: 10.1167/iovs.62.1.13. PMID: 33427853 
  • Paß T, Wiesner RJ, Pla-Martín D (2021). Selective Neuron Vulnerability in Common and Rare Diseases-Mitochondria in the Focus. Front Mol Biosci. 2021 Jun 30;8:676187. doi: 10.3389/fmolb.2021.676187. PMID: 34295920; PMCID: PMC8290884.
  • Imhof T, Rosenblatt K, Pryymachuk G, Weiland D, Noetzel N, Deschner J, Baris OR, Kimoloi S, Koch M, Wiesner RJ,Korkmaz Y (2021). Epithelial loss of mitochondrial oxidative phosphorylation leads to disturbed enamel and impaired dentin matrix formation in postnatal developed mouse incisor. Sci Rep. 2020 Dec 16;10(1):22037. doi: 10.1038/s41598-020-77954-7. PMID: 33328493 

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Andreas Wodarz

  • Rust K, Wodarz A (2021). Transcriptional Control of Apical-Basal Polarity Regulators. Int J Mol Sci. 2021 Nov 15;22(22):12340. doi: 10.3390/ijms222212340. PMID: 34830224

 

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Thomas Wunderlich

  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hövelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Büttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2021). Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood. 2021 Feb 4;137(5):646-660. doi: 10.1182/blood.2020005734. PMID: 33538798 
  • Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC (2021). Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 May 17. doi: 10.1038/s41593-021-00854-0. Epub ahead of print. PMID: 34002087. 
  • Borgmann D, Ciglieri E, Biglari N, Brandt C, Cremer AL, Backes H, Tittgemeyer M, Wunderlich FT, Brüning JC, Fenselau H (2021). Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab. 2021 May 21:S1550-4131(21)00219-9. doi: 10.1016/j.cmet.2021.05.002. Epub ahead of print. PMID: 34043943.
  • Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC,Hausen AC (2021). Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun. 2021 Sep 2;12(1):5249. doi: 10.1038/s41467-021-25380-2. PMID: 34475397
  • Porniece Kumar M, Cremer AL, Klemm P, Steuernagel L, Sundaram S, Jais A, Hausen AC, Tao J, Secher A, Pedersen TÅ, Schwaninger M, Wunderlich FT, Lowell BB, Backes H, Brüning JC (2021). Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab. 2021 Dec;3(12):1662-1679. doi: 10.1038/s42255-021-00499-0. 
  • Peters F, Rahn S, Mengel M, Scharfenberg F, Otte A, Koudelka T, Wagner EF, Wunderlich FT, Haase M, Naumann R, Tholey A, Becker-Pauly C (2021). Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis. Matrix Biol. 2021 Aug;102:37-69. doi: 10.1016/j.matbio.2021.08.002. 
  • Knopp, T., Lagrange, J., Jung, R., Wild, J., Rossmann, H., Spronk, H.M.H., Wunderlich, T., Hoevelmeyer, N., Münzel, T., Lämmle, B., Ruf, W., Wenzel, P., Waisman, A., and Karbach, S.H. (2021). Chronically Elevated Interleukin-6 Disturbs the Coagulation Cascade in Mice. Blood138. 10.1182/blood-2021-149628.
  • Schumacher, N., Yan, K., Gandrass, M., Müller, M., Krisp, C., Häsler, R., Carambia, A., Nofer, J.R., Bernardes, J.P., Khouja, M., Thomsen, I., Chalupsky, K., Bolik, J., Hölscher, C., Wunderlich, T., Herkel, J., Rosenstiel, P., Schramm, C., Schlüter, H., Renné, T., Mittrücker, H.W., Rose-John, S., and Schmidt-Arras, D. (2021). Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice. Journal of Hepatology74. 10.1016/j.jhep.2020.09.021.

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Branko Zevnik

  • Wigger M, Tröder SE, Zevnik B(2021). A simple and economic protocol for efficient in vitro fertilization using cryopreserved mouse sperm. PLoS One. 2021 Oct 28;16(10):e0259202. doi: 10.1371/journal.pone.0259202. PMID: 34710162; PMCID: PMC8553151.
  • Tröder SE, Zevnik B (2021). History of genome editing: From meganucleases to CRISPR. Lab Anim. 2021 Feb 23:23677221994613. doi: 10.1177/0023677221994613. Epub ahead of print. PMID: 33622064

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