Translational Infrastructure

The CECAD Translational Platform is led by Prof. Dr. Oliver Cornely, Dr. Ruth Hanssen, and Prof. Dr. Roman-Ulrich Müller, who are experts in clinical trial design, age-associated diseases, intervention and prevention studies in obesity and metabolic diseases and bench-to-bedside studies in aging kidney diseases. The CECAD Research Center located in the heart of the Cologne University Hospital campus, strongly supports the collaboration between CECAD basic researchers and clinicians, making Cologne a leading hub for translational research studies in Europe. The infrastructure and services of CECAD Translational Research Platform RP-B consist of:

The CECAD Institute of Translation (CIT) together with the Clinical Trials Center Cologne (CTCC) provide CECAD researchers with the expertise and tools needed to perform observational cohorts, and interventional clinical trials, including the use of human biosamples and registries.

In the CECAD Clinical Study Design Lab, as part of the CIT, 17 professionals support basic researchers and clinician scientists to co-develop translational concepts into clinical studies by offering comprehensive assistance from project design to publication. The lab provides expertise in drug and medical device development, clinical trial setup, and execution, increasing the likelihood of obtaining funding and regulatory approval. This lab works with clinical and academic sites in 95 countries and engages with industry partners. Contact: StudyDesignLab[at]ucgn.de

The CECAD biobank is supported by the UoC’s central biobank and adheres to national and international standards. New pipelines for mass spectrometry and clinical sample analysis enhance the capability to handle complex biosamples efficiently.

 

What else?

RP-B benefits also from strong partnerships with biotech companies, which play a crucial role in advancing clinical studies, improving patient diagnosis, and treatment. These cooperations ensure that our research efforts are aligned with industry standards and – most importantly – patient needs. Finally, the platform benefits from additional nationally and EU funded projects, raised by the platform leaders. Several awarded patents and pending applications stemming from translational projects demonstrate the success of our translational research.


Industrial Partners

  • Abcam - Joint efforts in antibody development against small metabolites. Collaborating with Prof. Christian Frezza.
  • Basilea - Strategic study design and comparator groups for licensing purposes in specific indications. Collaborating with Prof. Oliver A. Cornely.
  • Centogene - Strategic partnership for large-scale biosampling initiatives. Collaborating with Prof. Roman-Ulrich Müller.
  • F2G (UK) - Collaborative efforts in antifungal research and development. Collaborating with Prof. Oliver A. Cornely.
  • GSK (UK) - Partnership in clinical trials and therapeutic development. Collaborating with Prof. Oliver A. Cornely.
  • Melinta (US) - Collaboration on antimicrobial therapies and clinical trials. Collaborating with Prof. Oliver A. Cornely.
  • Mundipharma (UK) - Joint initiatives in pharmaceutical research and development. Collaborating with Prof. Oliver A. Cornely.
  • Novo Nordisk - Collaboration on therapeutic translation in diabetes and metabolic disorders. Collaborating with Prof. Jens C. Brüning.
  • Pfizer (US) - Collaboration on clinical trials and therapeutic innovations. Collaborating with Prof. Oliver A. Cornely.
  • Roche Pharma AG - Partnership on Value-based Healthcare initiatives in memory disorders. Collaborating with Prof. Frank Jessen.
  • Sanofi - Participation in an international multicenter study on respiratory infectious diseases. Collaborating with Prof. Cristina M. Polidori.
  • Scynexis (US) - Partnership in clinical trials and antifungal drug development. Collaborating with Prof. Oliver A. Cornely.
  • Shionogi (JPN) - European partner for strategic study design and clinical trials. Collaborating with Prof. Oliver A. Cornely.
  • UCB Pharma - Collaborative research on autophagy in neurodegenerative disorders. Collaborating with Prof. Natalia Kononenko.
Networks and Partner Centers
  • CESEK (Center for Rare Diseases) - an interdisciplinary institution which aims to improve the medical care of people with rare diseases by connecting patients, practitioners, and scientists.
  • CIM(Centre for Infection Medicine) - Located at the University Hospital of Cologne, involved in infectious disease research and collaborating with CECAD on various clinical trials and infection-related studies.
  • CTC (Clinical Trial Center Cologne) - Provides comprehensive support for conducting clinical trials at the University of Cologne. Collaborates with CECAD on various clinical trials and research projects.
  • DZIF (German Centre for Infection Research) - Clinical Trial Office and counseling for clinical trial projects. Spokesperson for the Product Development Unit for new compounds, devices, diagnostics, and treatment strategies is Prof. Oliver A. Cornely.
  • VACCELERATE Consortium - European Commission's pandemic readiness initiative, coordinated by Prof. Oliver A. Cornely. Engages with multiple European bodies including the Trial Coordination Board/CoMeCT and EMA/ETF.