Publications 2014

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Adam Antebi

  • Adams P, Antebi A, Cuervo AM, Kennedy B, Sedivy J (2014). Aging Cell: open access to all. Aging Cell. 13, 1
  • Denzel MS, Storm NJ, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, Sommer T, Hoppe T, Antebi A (2014). Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell. 156, 1167-1178
  • Fernandes de Abreu DA, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, Lopez-Moyado IF, Vaggi F, et al. (2014). An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genetics. 10, e1004225
  • Horn M, Geisen C, Cermak L, Becker B, Nakamura S, Klein C, Pagano M, Antebi A (2014). DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation. Developmental Cell. 28, 697-710
  • Judkins JC, Mahanti P, Hoffman JB, Yim I, Antebi A, Schroeder FC (2014). A photocleavable masked nuclear-receptor ligand enables temporal control of C. elegans development. Angew Chem Int Ed Engl. 53, 2110-2113
  • Mahanti P, Bose N, Bethke A, Judkins JC, Wollam J, Dumas KJ, Zimmerman AM, Campbell SL, Hu PJ, Antebi A, et al. (2014). Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metabolism. 19, 73-83

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Hisham Bazzi

  • Bazzi H, Anderson KV (2014). Centrioles in the mouse: cilia and beyond. Cell Cycle. 13(18), 2809
  • Bazzi H, Anderson KV (2014). Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A.111 (15), E1491-500
  • Insolera R, Bazzi H, Shao W, Shi SH, Anderson KV (2014). Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 17 (11), 1528-35

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Thomas Benzing

  • Borgal L, Rinschen M, Dafinger C, Hoff S, Reinert M, Lamkemeyer T, Lienkamp S, Benzing T, Schermer B (2014). Casein kinase 1 ? phosphorylates the Wnt regulator Jade-1 and modulates its activity. J Biol Chem. 289: 26344–56
  • Gravemann S, Brinkkoetter P, Vehreschild J, Franke B, Ehren K, Bünemann E, Orbach H, Weiß V, Hellmich M, Benzing T, Fätkenheuer G (2014). Low-grade proteinuria is highly prevalent in HIV-positive patients on antiretroviral treatment. AIDS. 28: 1783–9
  • Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke S, Dryer S, Schermer B, Benzing T, Brinkkoetter P (2014). Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J. 28: 1769–79
  • Hagmann H, Bossung V, Belaidi A, Fridman A, Karumanchi S, Thadhani R, Schermer B, Mallmann P, Schwarz G, Benzing T, Brinkkoetter P (2014). Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination. PLoS ONE. 9: e85258
  • Kohli P, Bartram M, Habbig S, Pahmeyer C, Lamkemeyer T, Benzing T, Schermer B, Rinschen M (2014). Label-free quantitative proteomic analysis of the YAP/TAZ interactome. Am J Physiol Cell Physiol. 306: C805-18
  • Kurschat C, Müller R, Franke M, Maintz D, Schermer B, Benzing T (2014). An approach to cystic kidney diseases: the clinician’s view. Nat Rev Nephrol. 10: 687–99
  • Mueller M, Castells-Roca L, Babu V, Ermolaeva M, Müller R, Frommolt P, Williams A, Greiss S, Schneider J, Benzing T, Schermer B, Schumacher B (2014). DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 16: 1168–79
  • Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks B, Beltrao P, Krueger M, Brinkkoetter P, Benzing T (2014). Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol. 25: 1509–22
  • Rinschen MM, Schermer B, Benzing T (2014). Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again. J Am Soc Nephrol. 25: 1140–7
  • Rohrig G, Klossok W, Becker I, Benzing T, Schulz R (2014). Prevalence of anemia among elderly patients in an emergency room setting. Eur Geriatr Med. 5: 3–7
  • Schurek E, Völker L, Tax J, Lamkemeyer T, Rinschen M, Ungrue D, Kratz J, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, Höhne M (2014). A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin. J Biol Chem. 289: 11262–71
  • Trachtman H, Benzing T, Sever S, Harris RC, Reiser J (2014). The grand challenge of nephrology. Front Med. 1: 28, 2014
  • Zilinski J, Zillmann R, Becker I, Benzing T, Schulz R, Roehrig G (2014). Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol. 93: 1645–54

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Matteo Bergami

  • Heinrich C, Bergami M, Gascon S, Lepier A, Vigano F, Dimou L, Sutor B, Berninger B, Götz M (2014). Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. Stem Cell Reports. 3, 1000-1014
  • Zuccaro E, Bergami M, Vignoli B, Guillame B, Pierchala BA, Santi S, Cancedda L, Canossa M (2014). Polarized expression of p75NTR specifies axons during development and adult neurogenesis. Cell Reports.7, 138-152

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Andreas Beyer

  • Clément-Ziza M, Marsellach FX, Codlin S, Papadakis MA, Reinhardt S, Rodríguez-López M, Martin S, Marguerat S, Schmidt A, Lee E Workman CT, Bähler J, Beyer A (2014). Natural genetic variation impacts expression levels of coding, non-coding, and antisense transcripts in fission yeast. Mol Syst Biol. 10:764
  • Kuhn M, Hyman AA, Beyer A (2014). Coiled-coil proteins facilitated the functional expansion of the centrosome. PLoS Comput Biol.10(6): e1003657. doi:10.1371/journal.pcbi.1003657
  • Simeone A, Marsico G, Collinet C, Galvez T, Kalaidzidis Y, Zerial M, Beyer A (2014). Revealing molecular mechanisms by integrating high-dimensional functional screens with protein interaction data. PLoS Comput Biol.10(9):e1003801 doi: 10.1371/journal.pcbi.1003801

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Susanne Brodesser

  • Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld J-W, Blüher M, Krönke M, Brüning JC (2014). Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 20(4):678-86
  • Neumann A, Brogden G, Jerjomicevaa N, Brodesser S, Naima HY, von Köckritz-Blickwede M (2014). Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps. Eur J Cell Biol. 93(8-9):347-54
  • Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke S, Dryer S, Schermer B, Benzing T, Brinkkoetter PT (2014). Breaking the chain at the membrane: Paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J. 28(4):1769-79
  • Stoffel W, Hammels I, Jenke B, Binczek E, Schmidt-Soltau I, Brodesser S, Odenthal M, Thevis M (2014). Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. EMBO Rep. 15(1):110-20
  • Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, de Angelis MH, Paulsson M, Schubert M, Wiesner RJ. (2014) Liver adapts mitochondrial function to insulin resistant and diabetic states in mice. J Hepatol 60(4):816-23

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Jens Brüning

  • Chong AC, Vogt MC, Hill AS, Brüning JC, Zeltser LM (2014). Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness. Mol Metab. Dec 10;4(2):83-92
  • Hess ME, Brüning JC (2014). Obesity: The need to eat-overruling the homeostatic control of feeding. Nat Rev Endocrinol. Jan;10(1):5-6
  • Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönnecke H, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC (2014). Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol. (15): 423–430
  • Nish SA, Schenten D, Wunderlich FT, Pope SD, Gao Y, Hoshi N, Yu S, Yan X, Lee HK, Pasman L, Brodsky I, Yordy B, Zhao H, Brüning JC, Medzhitov R (2014). T cell-intrinsic role of IL-6 signaling in primary and memory responses. Elife. May 19:e01949
  • Patti GJ, Tautenhahn R, Johannsen D, Kalisiak E, Ravussin E, Brüning JC, Dillin A, Siuzdak G (2014). Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension. Metabolomics. Aug 1;10(4):737-743
  • Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, Medzhitov R (2014). Signaling through the Adaptor Molecule MyD88 in CD4(+) T Cells Is Required to Overcome Suppression by Regulatory T Cells. Immunity. Jan 16;40(1):78-90
  • Steculorum S, Solas M, Brüning JC (2014). The paradox of neuronal insulin action and resistance in the development of aging-associated diseases. Alzheimers Dement.Feb;10(1 Suppl):S3-11
  • Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brönneke H, Collienne U, Hampel B, Wunderlich TF, Schmidt-Supprian M, Kloppenburg P, Brüning JC (2014). Distinct roles for JNK- and IKK-activation in AgRP neurons in the development of obesity and insulin resistance. Cell Rep. Nov 20;9(4):1495-506
  • Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodessor S, Hammerschmidt P, Wunderlich C, Mauer J, Xu E, Brönneke H, Trifunicnovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC (2014). Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. Oct 7;20(4):678-86
  • Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC (2014). Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding. Cell. Jan 30;156(3):495-509

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Oliver A. Cornely

  • Arenz D, Hero B, Eichhorst B, Langer M, Pester L, von Tresckow J, et al (2014). Estimating site costs prior to conducting clinical trials. Clin Invest. 2014;4(3):227-34
  • Bacher P, Kniemeyer O, Schonbrunn A, Sawitzki B, Assenmacher M, Rietschel E, et al (2014). Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi. Mucosal Immunology. 2014;7(4):916-28
  • Biehl LM, Schmidt-Hieber M, Liss B, Cornely OA, Vehreschild MJ (2014). Colonization and infection with extended spectrum beta-lactamase producing Enterobacteriaceae in high-risk patients - Review of the literature from a clinical perspective. Crit Rev Microbiol. Epub 2014 Feb 4
  • Buchheidt D, Spiess B, Cornely OA, Vehreschild MJ, Hamprecht A, Rath PM, et al (2014). Azole resistance in Aspergillus fumigatus - epidemiology and detection in immunocompromised patients in Germany. Dtsch Med Wochenschr. 2014;139(25-26):1373-6
  • Chowdhary A, Meis JF, Guarro J, de Hoog GS, Kathuria S, Arendrup MC, Arikan-Akdagli S, Akova M, Boekhout T, Caira M, Guinea J, Chakrabarti A, Dannaoui E, van Diepeningen A, Freiberger T, Groll AH, Hope WW, Johnson E, Lackner M, Lagrou K, Lanternier F, Lass-Flörl C, Lortholary O, Meletiadis J, Muñoz P, Pagano L, Petrikkos G, Richardson MD, Roilides E, Skiada A, Tortorano AM, Ullmann AJ, Verweij PE, Cornely OA, Cuenca-Estrella M (2014). ESCMID/ECMM Joint Clinical Guidelines for the Diagnosis and Management of Systemic Phaeohyphomycosis: Diseases Caused by Black Fungi. Clin Microbiol Infect. 2014 Jan 31
  • Cornely OA, Nathwani D, Ivanescu C, Odufowora-Sita O, Retsa P, Odeyemi IA (2014). Clinical efficacy of fidaxomicin compared with vancomycin and metronidazole in Clostridium difficile infections: a meta-analysis and indirect treatment comparison. J Antimicrob Chemother. 2014;69(11):2892-900
  • Cornely OA (2014). Invasive Pilzinfektionen: Aspergillose, Candidose, Mucormykose. Drug Res. 2014;64(Suppl 1):S14-5
  • Cornely OA, Vazquez J, De Waele J, Betts R, Rotstein C, Nucci M, Pappas PG, Ullmann AJ (2014). Efficacy of micafungin in invasive candidiasis caused by common Candida species with special emphasis on non-albicans Candida species. Mycoses. 2014 Feb;57(2):79-89
  • Cornely OA, Arikan-Akdagli S, Dannaoui E, Groll AH, Lagrou K, Chakrabarti A, Lanternier F, Pagano L, Skiada A, Akova M, Arendrup MC, Boekhout T, Chowdhary A, Cuenca-Estrella M, Freiberger T, Guinea J, Guarro J, de Hoog S, Hope W, Johnson E, Kathuria S, Lackner M, Lass-Flörl C, Lortholary O, Meis JF, Meletiadis J, Muñoz P, Richardson M, Roilides E, Tortorano AM, Ullmann AJ, van Diepeningen A, Verweij P, Petrikkos G (2014). ESCMID and ECMM Joint Clinical Guidelines for the Diagnosis and Management of Mucormycosis 2013. Clin Microbiol Infect. 2014 Jan 30
  • Duarte RF, Lopez-Jimenez J, Cornely OA, Laverdiere M, Helfgott D, Haider S, et al (2014). Phase 1b study of new posaconazole tablet for prevention of invasive fungal infections in high-risk patients with neutropenia. Antimicrobial Agents and Chemotherapy. 2014;58(10):5758-65
  • Ehren K, Hertenstein C, Kummerle T, Vehreschild JJ, Fischer J, Gillor D, et al (2014). Causes of death in HIV-infected patients from the Cologne-Bonn cohort. Infection. 2014;42(1):135-40
  • Heimann SM, Vehreschild MJ, Meintker L, Heinz W, Schroeder T, von Bergwelt-Baildon M, et al (2014). Different doses of micafungin for prophylaxis of invasive fungal diseases in hemato- oncological high-risk patients: a web-based non-interventional trial in four large university hospitals in Germany. Transplant infectious disease: an official journal of the Transplantation Society. 2014 Dec;16(6):968-74. doi: 10.1111/tid.12305. Epub 2014 Nov 5 
  • Heimann SM, Cornely OA, Vehreschild MJ, Glossmann J, Kochanek M, Kreuzer KA, Hallek M, Vehreschild JJ (2014). Treatment cost development of patients undergoing remission induction chemotherapy: a pharmacoeconomic analysis before and after introduction of posaconazole prophylaxis. Mycoses. 2014 Feb;57(2):90-7
  • Johnson S, Louie TJ, Gerding DN, Cornely OA, Chasan-Taber S, Fitts D, et al (2014). Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials. Clin Infect Dis. 2014;59(3):345-54
  • Koehler P, Tacke D, Cornely OA (2014). Aspergillosis of bones and joints - a review from 2002 until today. Mycoses. 2014 Jan 8. doi: 10.1111/myc.12165. Epub 2014 Jan 8
  • Maertens J, Cornely OA, Ullmann AJ, Heinz WJ, Krishna G, Patino H, et al (2014). Phase 1B Study of the Pharmacokinetics and Safety of Posaconazole Intravenous Solution in Patients at Risk for Invasive Fungal Disease. Antimicrobial Agents and Chemotherapy. 2014;58(7):3610-7
  • Mousset S, Buchheidt D, Heinz W, Ruhnke M, Cornely OA, Egerer G, Krüger W, Link H, Neumann S, Ostermann H, Panse J, Penack O, Rieger C, Schmidt-Hieber M, Silling G, Südhoff T, Ullmann AJ, Wolf HH, Maschmeyer G, Böhme A (2014). Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol. 2014 Jan;93(1):13-32
  • Nathwani D, Cornely OA, Van Engen AK, Odufowora-Sita O, Retsa P, Odeyemi IA (2014). Cost- effectiveness analysis of fidaxomicin versus vancomycin in Clostridium difficile infection. J Antimicrob Chemother. 2014;69(11):2901-12
  • Nucci M, Marr KA, Vehreschild MJ, de Souza CA, Velasco E, Cappellano P, et al (2014). Improvement in the outcome of invasive fusariosis in the last decade. Clin Microbiol Infect. 2014;20(6):580-5
  • Platten M, Linnemann R, Kummerle T, Jung N, Wyen C, Ehren K, et al (2014). Clinical course and quality of care in ART-naive patients newly presenting in a HIV outpatient clinic. Infection. 2014;42(5):849-57
  • Schweer KE, Wittersheim M, Bangard C, Frank KF, Cornely OA (2014). Chronic pulmonary Aspergillosis. Four exemplary clinical cases and literature overview. Dtsch Med Wochenschr. 2014;139(44):2242-7
  • Schweer KE, Bangard C, Hekmat K, Cornely OA (2014). Chronic pulmonary aspergillosis. Mycoses. 2014;57(5):257-70
  • Spiess B, Postina P, Reinwald M, Cornely OA, Hamprecht A, Hoenigl M, et al (2014). Incidence of Cyp51 A key mutations in Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995-2013. PloS One. 2014;9(7):e103113
  • Tacke D, Buchheidt D, Karthaus M, Krause SW, Maschmeyer G, Neumann S, et al (2014). Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Ann Hematol. 2014;93(9):1449-56
  • Tortorano AM, Richardson M, Roilides E, van Diepeningen A, Caira M, Munoz P, Johnson E, Meletiadis J, Pana ZD, Lackner M, Verweij P, Freiberger T, Cornely OA, Arikan-Akdagli S, Dannaoui E, Groll AH, Lagrou K, Chakrabarti A, Lanternier F, Pagano L, Skiada A, Akova M, Arendrup MC, Boekhout T, Chowdhary A, Cuenca-Estrella M, Guinea J, Guarro J, de Hoog S, Hope W, Kathuria S, Lortholary O, Meis JF, Ullmann AJ, Petrikkos G, Lass-Flörl C (2014). ESCMID & ECMM Joint Guidelines on Diagnosis and Management of Hyalohyphomycosis: Fusarium spp, Scedosporium spp, and others. Clin Microbiol Infect. 2014 Mar 9
  • Vehreschild MJ, Weitershagen D, Biehl LM, Tacke D, Waldschmidt D, Tox U, et al (2014). Clostridium difficile infection in patients with acute myelogenous leukemia and in patients undergoing allogeneic stem cell transplantation: epidemiology and risk factor analysis. Biol Blood Marrow Tr. 2014;20(6):823-8
  • Vehreschild MJ, von Bergwelt-Baildon M, Tran L, Shimabukuro-Vornhagen A, Wisplinghoff H, Bangard C, et al (2014). Feasibility and effectiveness of posaconazole prophylaxis in combination with micafungin bridging for patients undergoing allogeneic stem cell transplantation: A 6-yr analysis from the cologne cohort for neutropenic patients. Eur J Haematol. 2014 Nov;93(5):400-6. doi: 10.1111/ejh.12368. Epub 2014 May 26
  • Vehreschild MJ, Hamprecht A, Peterson L, Schubert S, Hantschel M, Peter S, et al (2014). A multicentre cohort study on colonization and infection with ESBL-producing Enterobacteriaceae in high-risk patients with haematological malignancies. J Antimicrob Chemother. 2014;69(12):3387-92
  • Walsh TJ, Skiada A, Cornely OA, Roilides E, Ibrahim A, Zaoutis T, et al (2014). Development of new strategies for early diagnosis of mucormycosis from bench to bedside. Mycoses. 2014;57 Suppl 3:2-7
  • Wille S, Tenholte D, Cornely OA, Muthen N, Engelmann UH, Mehner J, et al (2014). Prediction of overactive bladder treatment outcome by using long-term urodynamics. Der Urologe Ausg A. 2014 Dec;53(12):1812-4. doi: 10.1007/s00120-014-3629-7
  • Wille S, Schumacher P, Paas J, Tenholte D, Eminaga O, Muller U, et al (2014). Catheterless long-term ambulatory urodynamic measurement using a novel three-device system. PloS One. 2014;9(5):e96280

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Constantinos Demetriades 

  • Demetriades C, Doumpas N, Teleman AA (2014). Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell. 2014 February; 156(4):786-99

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Martin Denzel

  • Denzel MS, Storm NJ, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, Sommer T, Hoppe T, Antebi A (2014). Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell. 156 (6), 1167-1178  
  • Denzel MS, Antebi A (2014). Hexosamine pathway and (ER) protein quality control. Curr Opin Cell Biol. Apr;33:14-8

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Sabine Eming

  • Augustin M, and the German Konsensus conference (2014). The German national consensus on wound documentation and outcomes: Rationale, working programme and current status. Wound Medicine. 7:8-13
  • Brown A, Augustin M, Jünger M, Zutt M, Dissemond J, Rabe E, Kaufmann R, Simon M, Stücker M, Karrer S, Koenen W, Vanscheidt W, Scharfetter-Kochanek K, Wollina U, Krieg T, Eming SA (2014). Multicenter, randomized standard-of-care-controlled trial of a Silica gel fibre wound dressing in the treatment of chronic venous leg ulcers. Eur J Dermatol. 24:210-216
  • Brown A Neumayer D, Rafieé-Tari Z, Krieg T, Eming SA (2014). Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus. Hautarzt. 65:553-555
  • Brown A, Tantcheva-Poor I, Eming SA (2014). Parallelen zwischen Wundheilung, chronisch entzündlichen Dermatosen und Neoplasien – Wissenswertes für die Praxis. Der Hautarzt. 65:934-43
  • Coutelle O, Hornig-Do H, Schiffmann L, Brunold M, Liwschitz M, Brinkmann K, Seeger JM, Piekarek M, Andree M, Hallek M, Krönke M, Eming SA, Wiesner R, Hacker U, Kashkar H (2014). Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med. 6:624-639
  • Dissemond J, Augustin M, Eming SA, Görge T, Horn T, Karrer S, Schumann H, Stücker M für die Arbeitsgemeinschaft Wundheilung (AGW) der DDG (2014). Modern wound care - practical aspects of non-interventional topical treatment of patients with chronic wounds. J Dtsch Dermatol Ges. 12:541-54
  • Doerler M, Eming SA, Dissemond J, Wolter A, Stoffels-Weindorf M, Reich-Schupke S, Altmeyer P, Stücker M (2014). A Novel Epidermal Growth Factor-Containing Wound Dressing for the Treatment of Hard-to-Heal Venous Leg Ulcers. Adv Skin Wound Care. 27(10):456-60
  • Eming SA, Dissemond J, Jünger M (2014). Editorial Leitthemenheft, Schlecht heilende Wunden – Von der Behandlung verzauberter Geschwüre zur Etablierung strukturierter Behandlungsverfahren. Der Hautarzt. 65:926-7
  • Eming SA (2014). Editorial speciall issue: Evolution of immune pathways in regeneration and repair: novel concepts and biomedical perspectives. Seminars in Immunology. 26:275-6
  • Eming SA, Martin P, Tomic-Canic M (2014). Wound Repair and Regeneration: Mechanisms, signaling, and translation. Sci Transl Med. 6(265):265sr6
  • Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P; the CLEANSITE study group (2014). Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers – a randomized controlled trial. J Eur Acad Dermatol. 28:1742-50
  • Lettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R (2014). Col6a1 Null Mice as a Model to Study Skin Phenotypes in Patients with Collagen VI Related Myopathies: Expression of Classical and Novel Collagen VI Variants during Wound Healing. PLoS One. 26;9(8):e105686
  • Marcuzzi GP, Awerkiew S, Hufbauer M, Schädlich L, Gissmann L, Eming SA, Pfister H (2014). Tumor prevention in HPV8 transgenic mice by HPV8-E6 DNA vaccination. Med Micribiol Immunol. 203:155-163
  • Sallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H (2014). Tropism-modified AAV Vectors Overcome barriers to successful cutaneous therapy. Molecular Therapy. 22:929-939
  • Willenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartman K, Roers A, Eming SA (2014). Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis. J Invest Dermatol. 134:2005-2015
  • Willenborg S, Eming SA (2014). Macrophages – sensors and effectors coordinating skin damage and repair. J Dtsch Dermatol Ges. 12:214-221

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Lukas P. Frenzel

  • Pallasch CP, Leskov I, Braun CJ, Vorholt D, Drake A, Soto-Feliciano YM, Bent EH, Schwamb J, Iliopoulou B, Kutsch N, van Rooijen N, Frenzel LP, Wendtner CM, Heukamp L, Kreuzer KA, Hallek M, Chen J, Hemann MT (2014). Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell. 2014 Jan 30;156(3):590-602. doi: 10.1016/j.cell.2013.12.041

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Martin Graef

  • Vlahakis A, Graef M, Nunnari J, Powers T (2014). TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy. Proc Natl Acad Sci USA. 111, 10586-10591.1 

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Michael Hallek

  • Cramer P, Bahlo J, Eichhorst B, Fischer K, Hallek M (2014). Extramedullary manifestations of chronic lymphocytic leukaemia are not unusual. Leuk Res. 2014 Mar;38(3):284-5. doi:10.1016/j.leukres.2013.11.015
  • Furman RR, Sharman JP, Coutre SE, Cheson BD, Pagel JM, Hillmen P, Barrientos JC, Zelenetz AD, Kipps TJ, Flinn I, Ghia P, Eradat H, Ervin T, Lamanna N, Coiffier B, Pettitt AR, Ma S, Stilgenbauer S, Cramer P, Aiello M, Johnson DM, Miller LL, Li D, Jahn TM, Dansey RD, Hallek M, O'Brien SM (2014). Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia. N Engl J Med. 2014 Jan 22
  • Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM, Chagorova T, de la Serna J, Dilhuydy MS, Illmer T, Opat S, Owen CJ, Samoylova O, Kreuzer KA, Stilgenbauer S, Döhner H, Langerak AW, Ritgen M, Kneba M, Asikanius E, Humphrey K, Wenger M, Hallek M (2014). Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions. N Engl J Med. 2014 Mar 20;370(12):1101-10. doi: 10.1056/NEJMoa1313984. Epub 2014 Jan 8
  • Goede V, Cramer P, Busch R, Bergmann M, Stauch M, Hopfinger G, Stilgenbauer S, Doehner H, Westermann A, Wendtner CM, Eichhorst B, Hallek M (2014). Interactions between comorbidity and treatment of chronic lymphocytic leukemia: trial results of the German CLL Study Group. Haematologica. 2014 Jun;99(6):1095-100. doi: 10.3324/haematol.2013.096792. Epub 2014 Feb 28
  • Heimann SM, Cornely OA, Vehreschild MJ, Glossmann J, Kochanek M, Kreuzer KA, Hallek M, Vehreschild JJ (2014). Treatment cost development of patients undergoing remission induction chemotherapy: a pharmacoeconomic analysis before and after introduction of posaconazole prophylaxis. Mycoses. 2014 Feb;57(2):90-7. doi: 10.1111/myc.12105. Epub 2013 Jun 24
  • Pallasch CP, Leskov I, Braun CJ, Vorholt D, Drake A, Soto-Feliciano YM, Bent EH, Schwamb J, Iliopoulou B, Kutsch N, van Rooijen N, Frenzel LP, Wendtner CM, Heukamp L, Kreuzer KA, Hallek M, Chen J, Hemann MT (2014). Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell. 2014 Jan 30;156(3):590-602. doi: 10.1016/j.cell.2013.12.041
  • Sallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H (2014). Tropism-modified AAV Vectors Overcome Barriers to Successful Cutaneous Therapy. Mol Ther. 014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28
  • Tresckow B von, Boell B, Eichenauer D, Beschorner D, Knop S, Goebeler ME, Chemnitz JM, Hallek M, Engert A, Huebel K (2014). Anti-epidermal growth factor receptor antibody cetuximab in refractory or relapsed multiple myeloma: a phase II prospective clinical trial. Leuk Lymphoma. Mar;55(3):695-7. doi: 10.3109/10428194.2013.809074
  • Vyas M, Koehl U, Hallek M, Strandmann EP (2014). Natural ligands and antibody-based fusion proteins: harnessing the immune system against cancer. Trends Mol Med. Feb;20(2):72-82. doi: 10.1016/j.molmed.2013.10.006. Epub 2013 Nov 19

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Matthias Hammerschmidt

  • Fischer B, Metzger M, Richardson R, Knyphausen P, Ramezani T, Franzen R, Schmelzer E, Bloch W, Carney TJ, Hammerschmidt M (2014). p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genet. 10, e1004048
  • Keupp K, Li Y, Vargel I, Hoischen A, Richardson R, Neveling K, Alanay Y, Uz E, Elcioğlu N, Rachwalski M, Kamaci S, Tunçbilek G, Akin B, Grötzinger J, Konas E, Mavili E, Müller-Newen G, Collmann H, Roscioli T, Buckley MF, Yigit G, Gilissen C, Kress W, Veltman J, Hammerschmidt M, Akarsu NA, Wollnik B (2014). Mutations in the interleukin receptor IL11RA cause autosomal Crouzon-like craniosynostosi. Mol Genet Genomic Med. 1, 223-237
  • Richardson R, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlson KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R (2014). AMACO is a novel component of the basement membrane associated Fraser complex. J Invest Dermatol. 134, 1313-1322
  • Wishart TM, Mutsaers CA, Riessland M, Reimer MM, Hunter G, Hannam ML, Eaton SL, Fuller HR, Roche SL, Somers E, Morse R, Young PJ, Lamont DJ, Hammerschmidt M, Joshi A, Hohenstein P, Morris GE, Parson SH, Skehel PA, Becker T, Robinson IM, Becker CG, Wirth B, Gillingwater TH (2014). Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote muscular atrophy. J Clin Invest. 124, 1821-1834

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Hans Christian Hennies

  • Alnasif N, Zoschke C, Fleige E, Brodwolf R, Boreham A, Rühl E, Eckl KM, Merk HF, Hennies HC, Alexiev U, Haag R, Küchler S, Schäfer-Korting M (2014). Penetration of normal, damaged and diseased skin – An in vitro study on dendritic core-multishell nanotransporters. J Control Release. 185:45-50 
  • Eckl KM, Weindl G, Ackermann K, Küchler S, Casper R, Radowski MR, Haag R, Hennies HC, Schäfer-Korting M (2014). Increased cutaneous absorption reflects impaired barrier function of reconstructed skin models mimicking keratinisation disorders. Exp Dermatol. 23:286-288 
  • Schiller S, Seebode C, Hennies HC, Giehl K, Emmert S (2014). Palmoplantar keratoderma (PPK): Genetic causes of a not so rare disease. JDDG. 12(9):781-788 

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Marco Herling

  • Hopfinger G, Herling M (2014). Therapie der Prolymphozytenleukämie der T-Zell Reihe (T-PLL). In: Hallek M and Emmerich B eds., Chronische lymphatische Leukämie. (chapter 6.5, in German), 5th edition 2014, UNI-MED Science (ISBN: 978-3-8374-2263-4)
  • Kiel MJ, Velusamy T, Rolland D, Sahasrabuddhe AA, Chung F, Bailey NG, Schrader A, Li B, Jun Z. Li JZ, Ozel AB, Betz BL, Miranda RN, Medeiros LJ, Zhao L, Herling M, Lim MS, Elenitoba-Johnson KJS (2014). Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia. Blood. 2014, Aug 28;124(9):1460-72
  • Schrader A, Popal W, Lilienthal N, Crispatzu G, Mayer P, Jones D, Hallek M, Herling M (2014). AKT-pathway inhibition in chronic lymphocytic leukemia reveals response relationships defined by TCL1. Curr Cancer Drug Targets. 2014;14(8):700-12

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Thorsten Hoppe

  • Bonizec M, Herissant L, Pokrzywa W, Geng F, Wenzel S, Howard GC, Rodriguez P, Krause S, Tansey WP, Hoppe T, Dargemont C (2014).The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B. Nucleic Acids Res. 42, 10975-86
  • Denzel MS, Storm NJ, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, Sommer T, Hoppe T, Antebi A (2014). Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell. 156, 1167-78
  • Finger F, Hoppe T (2014). MicroRNAs meet calcium: Joint venture in ER proteostasis. Sci Signal. 7, re11
  • Franz A, Ackermann L, Hoppe T (2014). Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP. Biochim Biophys Acta. 1843, 205-15
  • Frumkin A, Dror S, Pokrzywa W, Bar-Lavan Y, Karady I, Hoppe T, Ben-Zvi A (2014). Challenging muscle homeostasis uncovers novel chaperone interactions in C. elegans. Front Mol Bio. 6, 1:21
  • Hoppe T (2014). Limited Proteolysis: DisRUPting Proteasomal Inhibition. Curr Biol. 24, R693-5
  • Hou NS, Gutschmidt A, Choi DY, Pather K, Shi X, Watts JL, Hoppe T, Taubert S (2014).Activation of the ER unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Proc Natl Acad Sci. 111, E2271-80
  • Kevei E, Hoppe T (2014). Ubiquitin sets the timer: impacts on aging and longevity. Nat Struct Mol Biol. 21, 290-2
  • Livnat-Levanon N, Kevei E, Kleifeld O, Krutauz D, Segref A, Rinaldi T, Erpapazoglou Z, Cohen M, Reis N, Hoppe T, Glickman MH (2014). Reversible 26S Proteasome disassembly upon mitochondrial stress. Cell Rep. 7, 1371-80
  • Segref A, Kevei E, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T (2014). Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab. 19, 642-52

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Sandra Iden 

  • Mescher M, Iden S (2014). Function of mammalian cell polarity regulators in skin cancer. Cell News. Issue 04
  • Schlereth SL, Refaian N, Iden S, Cursiefen C, Heindl LM (2014). Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis. Biomed Res Int. Epub 2014 Sep 1. Review

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    Hamid Kashkar

    • Albert MC, Brinkmann K, Kashkar H (2014). Noxa in cancer therapy; Tuning up the mitochondrial death machinery in response to chemotherapy. Mol Cell Oncol. 1:e29906
    • Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich C, Brinkmann K, Broxtermann PN, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Koch A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer T, Utermöhlen O, Kashkar H (2014). BID-mediated release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 2014,33:2171-2187
    • Bielig H, Lautz K, Braun PR, Menning M, Machuy N, Brügmann C, Barisic S, Eisler SA, Andree M, Kashkar H, Zurek B, Hausser A, Sansonetti PJ, Meyer TF, Kufer TA (2014). The cofilin phosphatase Slingshot Homolog 1 (SSH1) links NOD1 signalling to actin remodeling. PLoS Pathog. 2014, 10:e1004351
    • Brinkmann K, Hombach A, Seeger JM, Wagner-Stippich D, Klubertz D, Krönke M, Abken H, Kashkar H (2014). Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing. Leuk Lymphoma. 55:645-651
    • Brinkmann K, Kashkar H (2014). Targeting the Mitochondrial Apoptotic Pathway; A Preferred Approach in Hematologic Malignancies? Cell Death Dis. 5: e1098
    • Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Liwschitz M, Seeger JM, Piekarek M, Brinkmann K, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H (2014). Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med. 6:624-639
    • Fröhlich M, Dejanovic B, Kashkar H, Schwarz G, Nussberger S (2014). S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Cell Death Dis. 5:e1057

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    Peter Kloppenburg

    • Kloppenburg P, Nawrot MP (2014). Neural coding: sparse but on time. Curr Biol. 2014 Oct 6;24(19):R957-9. doi: 10.1016/j.cub.2014.08.041
    • Neuhaus JF, Baris OR, Hess S, Moser N, Schröder H, Chinta SJ, Andersen JK, Kloppenburg P, Wiesner RJ (2014). Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons. Brain. 2014 Feb;137(Pt 2):354-65. doi: 10.1093/brain/awt291
    • Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brönneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brüning JC (2014). Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. Cell Rep. 2014 Nov 20;9(4):1495-506. doi: 10.1016/j.celrep.2014.10.045
    • Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC (2014). Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell. 2014 Jan 30;156(3):495-509. doi: 10.1016/j.cell.2014.01.008
    • Warren B, Kloppenburg P (2014). Rapid and slow chemical synaptic interactions of cholinergic projection neurons and GABAergic local interneurons in the insect antennal lobe. J Neurosci. 2014 Sep 24;34(39):13039-46. doi: 10.1523/JNEUROSCI.0765-14.2014

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    Natalia Kononenko

    • Kononenko NL, Puchkov D, Classen GA, Walter AM, Pechstein A, Sawade L, Kaempf N, Trimbuch T, Lorenz D, Rosenmund C, Maritzen T, Haucke V (2014).Clathrin/AP-2 Mediate Synaptic Vesicle Reformation from Endosome-like Vacuoles but Are Not Essential for Membrane Retrieval at Central Synapses. Neuron. 82, 981-988, doi:10.1016/j.neuron.2014.05.007

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    Jan-Wilhelm Kornfeld

    • Kornfeld JW, Brüning JC (2014). Regulation of metabolism by long, noncoding RNAs. Front Genet. 2014 Mar 25;5:57. doi: 10.3389/fgene.2014.00057
    • Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC (2014). Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance. Cell Metab. 2014 Oct 7;20(4):678-86. doi: 10.1016/j.cmet.2014.08.002

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    Thomas Krieg

    • Brown A, Augustin M, Junger M, Zutt M, Dissemond J, Rabe E, Kaufmann R, Simon M, Stucker M, Karrer S, Koenen W, Vanscheidt W, Scharfetter-Kochanek K, Wollina U, Krieg T, Eming SA (2014). Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. Eur J Dermatol. 24, 210-216
    • Brown A, Neumayer D, Rafiee-Tari Z, Krieg T, Eming SA (2014). Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus. Hautarzt. 65, 553-555
    • Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, Krieg T (2014). Molecular and cellular basis of scleroderma. J Mol Med (Berl). 92, 913-924
    • Eckes B, Krieg T, Wickstrom SA (2014). Role of integrin signalling through integrin-linked kinase in skin physiology and Pathologe. Exp Dermatol. 2014, 23, 453-456
    • Kumari S, Herzberg B, Pofahl R, Krieg T, Haase I (2014). Epidermal ReiA specifically restricts contact allergen-induced inflammation and apoptosis in skin. J Invest Dermatol. 134, 2541-2550
    • Logan A, Cochemé HM, Li Pun PB, Apostolova N, Smith RA, Larsen L, Larsen DS, James AM, Fearnley IM, Rogatti S, Prime TA, Finichiu PG, Dare A, Chouchani ET, Pell VR, Methner C, Quin C, McQuaker SJ, Krieg T, Hartley RC, Murphy MP (2014). Using exomarkers to assess mitochondrial reactive species in vivo. Biochim Biophys Acta. 2014 Feb;1840(2):923-30. doi: 10.1016/j.bbagen.2013.05.026. Epub 2013 May 30
    • Moinzadeh P, Aberer E, Ahmadi-Simab K, Blank N, Distler JH, Fierlbeck G, Genth E, Guenther C, Hein R, Henes J, Herich L, Herrgott I, Koetter I, Kreuter A, Krieg T, Kuhr K, Lorenz HM, Meier F, Melchers I, Mensing H, Mueller-Ladner U, Pfeiffer C, Riemekasten G, Sárdy M, Schmalzing M, Sunderkoetter C, Susok L, Tarner IH, Vaith P, Worm M, Wozel G, Zeidler G, Hunzelmann N, all participating DNSS centers (2014). Disease progression in systemic sclerosis-overlap syndrome is significantly different from limited and diffuse cutaneous systemic sclerosis. Ann Rheum Dis. Jan 3. doi: 10.1136/annrheumdis-2013-204487. Epub 2014 Jan 3
    • Niessen CM, Krieg T (2014). Clinician scientists and PhDs: the need to connect basic research to translational medicine-a personal experience. J Invest Dermatol. Feb;134(2):295-8. doi: 10.1038/jid.2013.466
    • Pun PB, Logan A, Darley-Usmar V, Chacko B, Johnson MS, Huang GW, Rogatti S, Prime TA, Methner C, Krieg T, Fearnley IM, Larsen L, Larsen DS, Menger KE, Collins Y, James AM, Kumar GD, Hartley RC, Smith RA, Murphy MP (2014). A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radic Biol Med. Feb;67:437-50. doi: 10.1016/j.freeradbiomed.2013.11.025. Epub 2013 Dec 4
    • Willenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartmann K, Roers A, Eming SA (2014). Genetic Ablation of Mast Cells Redefines the Role of Mast Cells in Skin Wound Healing and Bleomycin-Induced Fibrosis. J Invest Dermatol. Jan 9. doi: 10.1038/jid.2014.12. Epub 2014 Jan 9

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    Martin Krönke

    • Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H (2014). BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 2171-87
    • Brinkmann K, Hombach A, Seeger JM, Wagner-Stippich D, Klubertz D, Krönke M, Abken H, Kashkar H (2014). Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing.Leuk Lymphoma. Mar 55: 645-51
    • Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H (2014). Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med. 6: 624-39
    • Fischer J, van Koningsbruggen-Rietschel S, Rietschel E, Vehreschild MJ, Wisplinghoff H, Krönke M, Hamprecht A (2014). Prevalence and molecular characterization of azole resistance in Aspergillus spp. isolates from German cystic fibrosis patients. J Antimicrob Chemother. 69: 1533-6
    • Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC (2014). Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance. Cell Metab. 20: 678-86
    • Schramm M, Wiegmann K, Schramm S, Gluschko A, Herb M, Utermöhlen O, Krönke M (2014). Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes.Eur J Immunol. Mar 44: 728-41
    • Zituni D, Schütt-Gerowitt H, Kopp M, Krönke M, Addicks K, Hoffmann C, Hellmich M, Faber F, Niedermeier W (2014). The growth of Staphylococcus aureus and Escherichia coli in low-direct current electric fields. Int J Oral Sci. Mar 6: 7-14

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    Marcus Krüger

    • Al-Furoukh N, Kardon JR, Krüger M, Szibor M, Baker TA, Braun T (2014). NOA1, a Novel ClpXP Substrate, Takes an Unexpected Nuclear Detour Prior to Mitochondrial Import. PLoS One. 2014 Jul 29;9(7):e103141
    • Biesemann N, Mendler L, Wietelmann A, Hermann S, Schäfers M, Krüger M, Boettger T, Borchardt T, Braun T (2014). Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure. Circ Res. Jul 7; 115(2):296-310
    • Bohla D, Herold M, Panzer I, Buxa MK, Ali T, Demmers J, Krüger M, Scharfe M, Jarek M, Bartkuhn M, Renkawitz R (2014). A Functional Insulator Screen Identifies NURF and dREAM Components to Be Required for Enhancer-Blocking. PLoS One. 2014 Sep 23;9(9)
    • Hölper S, Ruhs A, Krüger M (2014). Stable isotope labeling for proteomic analysis of tissues in mouse. Methods Mol Biol. 1188:95-106
    • Nolte H, Konzer A, Ruhs A, Jungblut B, Braun T, Krüger M (2014). Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. J Proteome Res. Apr 4; 13(4):2162-74 
    • Nolte H, Hölper S, Selbach M, Braun T, KrügerM (2014). Native SILAC flooding dose approach for serum protein dynamics (SILflood). Analytical Chemistry. 86 (22), 11033-11037
    • Sheean ME, McShane E, Cheret C, Walcher J, Müller T, Wulf-Goldenberg A, Hoelper S, Garratt AN, Krüger M, Rajewsky K, Meijer D, Birchmeier W, Lewin GR, Selbach M, Birchmeier C (2014). Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination. Genes Dev. Feb 1;28(3):290-303
    • Singh S, Aravamudhan S, Armant O, Krüger M, Grabher C (2014). Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation Fish & Shellfish. Immunology. Sep; 40(1):217-24
    • Zaglia T, Milan G, Ruhs A, Franzoso M, Bertaggia E, Pianca N, Carpi A, Carullo P, Pesce P, Sacerdoti D, Sarais C, Catalucci D, Krüger M, Mongillo M, Sandri M (2014). Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy. J Clin Invest. 124(6):2410-24

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    Leo Kurian

    • Aguirre A, Montserrat N, Zacchigna S, Nivet E, Hishida T, Krause MN, Kurian L, Ocampo A, Vazquez-Ferrer E, Rodriguez-Esteban C, Kumar S, Moresco JJ, Yates JR, Campistol JM, Sancho-Martinez I, Giacca M, Izpisua Belmonte JC (2014). In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell. Nov 6;15(5):589-604
    • Pulecio J, Nivet E, Sancho-Martinez I, Vitaloni M, Guenechea G, Xia Y, Kurian L, Dubova I, Bueren J, Laricchia-Robbio L, Izpisua Belmonte JC (2014). Conversion of human fibroblasts into monocyte-like progenitor cells. Stem Cells. Nov ;32(11):2923-38

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    Thomas Langer

    • Almontashiri NA, Chen HH, Mailloux RJ, Tatsuta T, Teng AC, Mahmoud AB, Ho T, Stewart NA, Rippstein P, Harper ME, Roberts R, Willenborg C, Erdmann J, for the CARDIoGRAM Consortium, Pastore A, McBride HM, Langer T, Stewart AF (2014). SPG7 variant excapes phosphorylation-regu­lated processing by AFG3L2, elevates mitochondrial ROS, and is associated with mul­tiple clinical phenotypes. Cell Rep. 7, 834-847. doi: 10.1016/j.celrep.2014.03.051
    • Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T (2014). The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol. 204, 919-929. doi: 10.1083/jcb.201308006
    • Bahat A, Perlberg S, Melamed-Book N, Lauria I, Langer T, Orly J (2014). StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation. Mol Endocrinol. 28, 208-224. doi: 10.1210/me.2013-1275
    • Baker MJ, Lampe PA, Stojanovski D, Korwitz A, Anand R, Tatsuta T, Langer T (2014). Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. EMBO J. 33, 578-593. doi 10.1002/embj. 201386474
    • Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H (2014). The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Parente. EMBO Rep. 15, 7-11. doi: 10.1002/embr.201338230
    • Escobar-Henriques M, Langer T (2014). Dynamic survey of mitochondria by ubiquitin. EMBO Rep. 15, 231-243. doi: 10.1002/embr.201338225
    • Kondadi AK, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, Herholz D, Baker MJ, Schauss AC, Langer T, Rugarli EI (2014). Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphor­ylation. EMBO J. 33, 1011-1026. doi: 10.1002/embj.201387009
    • Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker MJ, Decker T, Lamkemeyer T, Rugarli EI, Langer T (2014). DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Cell Metabol. 20, 158-171. doi: 10.1016/j.cmet.2014.04.016
    • Sepulveda-Falla D, Barrera-Ocampo A, Hagel C, Korwitz A, Vinueza-Veloz MF, Zhou K, Schonewille M, Zhou H, Velazquez-Perez L, Rodriguez-Labrada R, Villegas A, Ferrer I, Lopera F, Langer T, De Zeeuw CL, Glatzel M (2014). Familial Alzheimer’s disease-associated presenilin-1 alters cerebellar activity and cal­cium homeostasis. J Clin Invest. 124, 1552-1567. doi 10.1172/JCl66407

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    Nils-Göran Larsson

    • Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG (2014). Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. Nucleic Acids Res. Dec 16;42(22):13920-38. Epub 2014 Nov 26
    • Baines HL, Stewart JB, Stamp C, Zupanic A, Kirkwood TB, Larsson NG, Turnbull DM, Greaves LC (2014). Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans. Mech Ageing Dev. 139:22-30
    • Hagström E, Freyer C, Battersby BJ, Stewart JB, Larsson NG (2014). No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal Germaine. Nucleic Acids Res. Jan 1;42(2):1111-6. doi: 10.1093/nar/gkt969. Epub 2013 Oct 25
    • Hällberg BM, Larsson NG (2014). Making proteins in the powerhouse. Cell Metab. 20:226-240
    • Kühl I, Kukat C, Ruzzenente B, Milenkovic D, Mourier A, Miranda M, Koolmeister C, Falkenberg M, Larsson NG (2014). POLRMT does not transcribe nuclear genes (Brief Communications Arising). Nature. 514:E7-E11
    • Li L, Trifunovic A, Köhhler M, Wang Y, Petrovic Berglund J, Illies C, Juntti-Berggren L, Larsson NG, Berggren PO (2014). Defects in β-Cell Ca2+ Dynamics in Age-Induced Diabetes. Diabetes. Dec;63(12):4100-14. Epub 2014 Jul 1
    • Metodiev MD, Spåhr H, Loguercio Polosa P, Meharg C, Becker C, Altmueller J, Habermann B, Larsson NG, Ruzzenente B (2014). NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly. PLoS Genet. Feb 6;10(2):e1004110. doi: 10.1371/journal.pgen.1004110. eCollection 2014 Feb
    • Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG (2014). Loss of LRPPRC causes ATP synthase deficiency. Hum Mol Genet. Jan 8. :23:2580-2592
    • Mourier A, Matic S, Ruzzenente B, Larsson NG, Milenkovic D (2014). The Respiratory Chain Supercomplex Organization Is Independent of COX7a2l Isoforms. Cell Metab. Dec 2;20(6):1069-75
    • Posse V, Hoberg E, Dierckx A, Shahzad S, Koolmeister C, Larsson NG, Wilhelmsson LM, Hällberg BM, Gustafsson CM (2014). The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation. Nucleic Acids Res. Jan 20. :42:3638-3647
    • Sharoyko VV, Abels M, Sun J, Nicholas LM, Mollet IG, Stamenkovic JA, Göhring I, Malmgren S, Storm P, Fadista J, Spégel P, Metodiev MD, Larsson NG, Eliasson L, Wierup N, Mulder H (2014). Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. Hum Mol Genet. Nov 1;23(21):5733-49. Epub 2014 Jun 10
    • Stewart JB, Larsson NG (2014). Keeping mtDNA in shape between generations. PLoS Genet. Oct 9;10(10):e1004670
    • Uhler JP, Spåhr H, Farge G, Clavel S, Larsson NG, Falkenberg M, Samuelsson T, Gustafsson CM (2014). The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. Biochem Biophys Res Commun. 2014 Jan 3;443(1):7-12. doi: 10.1016/j.bbrc.2013.10.137. Epub 2013 Nov 6
    • Vernochet C, Damilano F, Mourier A , Bezy O, Mori MA, Smith G, Rosenzweig, Larsson NG, Kahn CR (2014). Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis and cardiovascular complications. FASEB J. Oct;28(10):4408-19. Epub 2014 Jul 8
    • Wilson WC, Hornig-Do HT, Bruni F, Chang JH, Jourdain AA, Martinou JC, Falkenberg M, Spåhr H, Larsson NG, Lewis RJ, Hewitt L, Baslé A, Cross HE, Tong L, Lebel RR, Crosby AH, Chrzanowska-Lightowlers ZM, Lightowlers RN (2014). A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Hum Mol Genet. Epub 2014 Jul 9

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    Ivan Matic

    • Tammsalu T, Matic I, Jaffray EG, Ibrahim AF, Tatham MH, Hay RT (2014). Proteome-Wide Identification of SUMO2 Modification Sites. Science Signaling. 2014 Apr 29
    • Vyas S, Matic I, Uchima L, Rood J, Zaja R, Hay RT, Ahel I, Chang P (2014). Family-wide analysis of poly (ADP-ribose) polymerase activity. Nat Commun. 2014 Jul 21

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    Roman-Ulrich Müller

    • Kurschat CE, Müller RU, Franke M, Maintz D, Schermer B, Benzing T (2014). An approach to cystic kidney diseases: the clinician’s view. Nat Rev Nephrol. 2014 Dec;10(12):687-99. doi: 10.1038/nrneph.2014.173. Epub 2014 Sep 30
    • Mueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B (2014). DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 2014 Dec;16(12):1168-79. doi: 10.1038/ncb3071. Epub 2014 Nov 24
    • Stippel DL, Cingöz T, Wahba R, Müller RU, Bauerfeind U, Dieplinger G (2014). 25 Years of Kidney Transplantation--A Period of Change. Clin Transpl. 2014:69-76

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    Carien Niessen

    • Niessen CM, Krieg T (2014). Clinician Scientists and PhDs: The Need to Connect Basic Research to Translational Medicine-A Personal Experience. J Invest Dermatol. 134: 295-298
    • Sallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H (2014). Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy. Mol Ther. 22(5):929-39
    • Tellkamp F, Vorhagen S, Niessen CM (2014). Epidermal Polarity Genes in Health and Disease. Cold Spring Harbor Perspectives Med. 1;4(12):a015255. doi: 10.1101/cshperspect.a015255
    • Vorhagen S, Niessen CM (2014). Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate. Exp Cell Research. 328:296-302

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    Angelika A. Noegel

    • Burgute BD, Peche VS, Steckelberg AL, Glöckner G, Gaßen B, Gehring NH, Noegel AA (2014). NKAP is a novel RS related protein that interacts with RNA and RNA binding proteins. Nucleic Acids Res. 42, 3177-3193
    • Glöckner G, Hülsmann N, Schleicher M, Noegel AA, Eichinger L, Gallinger C, Pawlowski J, Sierra R, Euteneuer U, Pillet L, Moustafa A, Platzer M, Groth M, Szafranski K, Schliwa M (2014). The genome of the foraminiferan Reticulomyxa filosa. Curr Biol. 2014 Jan 6;24(1):11-8. doi: 10.1016/j.cub.2013.11.027. Epub 2013 Dec 12
    • Hussain MS, Battaglia A, Szczepanski S, Kaygusuz E, Toliat MR, Sakakibara SI, Altmüller J, Thiele H, Nürnberg G, Moosa S, Yigit G, Beleggia F, Tinschert S, Clayton-Smith J, Vasudevan P, Urquhart JE, Donnai D, Fryer A, Percin F, Brancati F, Dobbie A, Śmigiel R, Gillessen-Kaesbach G, Wollnik B, Noegel AA, Newman WG, Nürnberg P (2014). Mutations in CKAP2L, the Human Ortholog of the Mouse Radmis Gene, Cause Filippi Syndrome. Am J Hum Genet. 95, 622-632
    • Li P, Meinke P, Thanh Huong LT, Wehnert M, Noegel AA (2014). Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies. Hum Mut. 35, 452-461
    • Liggett JS, Choi CK, Donnell RL, Kihm KD, Kim JS, Min KW, Noegel AA, Baek SJ (2014). Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein Nesprin-2 expression in colorectal cancer cells. Biochem Biophys Acta (general subjects). 1840, 322-331
    • Martin CA, Ahmad I, Klingseisen A, Hussain MS, Bicknell LS, Leitch A, Nürnberg G, Toliat MR, Murray JE, Hunt D, Khan F, Ali Z, Tinschert S, Ding J, Keith C, Harley ME, Heyn P, Müller R, Hoffman I, Daire VC, Dollfus H, Dupuis L, Bashamboo A, McElreavey K, Kariminejad A, Mendoza-Londono R, Moore AT, Saggar A, Schlechter C, Weleber R, Thiele H, Altmüller J, Höhne W, Hurles ME, Noegel AA, Baig SM, Nürnberg P, Jackson AP (2014). Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet. 46, 1283-1292
    • Neumann S, Noegel AA (2014). Nesprins in cell stability and migration. Adv Exp Med Biol. 2014;773:491-504. doi: 10.1007/978-1-4899-8032-8_22
    • Omosigho NN, Swaminathan K, Plomann M, Müller-Taubenberger A, Noegel AA, Riyahi TY (2014). The Dictyostelium discoideum RACK1 orthologue has roles in growth and development. Cell Commun Signal. 12:37
    • Sur I, Neumann S, Noegel AA (2014). Nesprin-1 role in DNA damage response. Nucleus. 5, 173-191
    • Swaminathan K, Müller-Taubenberger A, Faix J, Rivero F, Noegel AA (2014). A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E25-33. doi: 10.1073/pnas.1315368111. Epub 2013 Dec 17
    • Voelkl J, Alesutan I, Pakladok T, Viereck R, Feger M, Mia S, Schönberger T, Noegel AA, Gawaz M, Lang F (2014). Annexin A7 deficiency potentiates cardiac NFAT activity promoting hypertrophic signaling. Biochem Biophys Res Commun. 2014 Feb 28;445(1):244-9. doi: 10.1016/j.bbrc.2014.01.186. Epub 2014 Feb 6

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    Peter Nürnberg

    • Altmüller J, Budde BS, Nürnberg P (2014). Enrichment of target sequences for next-generation sequencing applications in research and diagnostics. Biol Chem. 395, 231-237
    • Anney RJL, Avbersek A, Balding D, Baum L, Becker F, Berkovic SF, Bradfield JP, Brody LC, Buono RJ, Catarino CB, Cavalleri GL, Cherny SS, Chinthapalli K, Coffey AJ, Compston A, Cossette P, de Haan GJ, De Jonghe P, de Kovel CGF, Delanty N, Depondt C, Dlugos DJ, Doherty CP, Elger CE, Ferraro TN, Feucht M, Franke A, French J, Gaus V, Goldstein DB, Gui HS, Guo YL, Hakonarson H, Hallmann K, Heinzen EL, Helbig I, Hjalgrim H, Jackson M, Jamnadas-Khoda J, Janz D, Johnson MR, Kalviainen R, Kantanen AM, Kasperaviciute D, Trenite DKN, Koeleman BPC, Kunz WS, Kwan P, Lau YL, Lehesjoki AE, Lerche H, Leu C, Lieb W, Lindhout D, Lo W, Lowenstein DH, Malovini A, Marson AG, McCormack M, Mills JL, Moerzinger M, Moller RS, Molloy AM, Muhle H, Newton M, Ng PW, Nothen MM, Nürnberg P, Obrien TJ, Oliver KL, Palotie A, Pangilinan F, Pernhorst K, Petrovski S, Privitera M, Radtke R, Reif PS, Rosenow F, Ruppert AK, Sander T, Scattergood T, Schachter S, Schankin C, Scheffer IE, Schmitz B, Schoch S, Sham PC, Sisodiya S, Smith DF, Smith PE, Speed D, Sperling MR, Steffens M, Stephani U, Striano P, Stroink H, Surges R, Tan KM, Thomas GN, Todaro M, Tostevin A, Tozzi R, Trucks H, Visscher F, von Spiczak S, Walley NM, Weber YG, Wei Z, Whelan C, Yang WL, Zara F, Zimprich F, Int League Epilepsy Consortium C, Grp KS (2014). Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. Lancet Neurol. 13, 893-903
    • Basmanav FB, Oprisoreanu AM, Pasternack SM, Thiele H, Fritz G, Wenzel J, Größer L, Wehner M, Wolf S, Fagerberg C, Bygum A, Altmüller J, Rütten A, Parmentier L, El Shabrawi-Caelen L, Hafner C, Nürnberg P, Kruse R, Schoch S, Hanneken S, Betz RC (2014). Mutations in POGLUT1, encoding protein O-glucosyltransferase 1, cause autosomal-dominant Dowling-Degos disease. Am J Hum Genet. 94, 135-143
    • Beck BB, Phillips JB, Bartram MP, Wegner J, Thoenes M, Pannes A, Sampson J, Heller R, Göbel H, Koerber F, Neugebauer A, Hedergott A, Nürnberg G, Nürnberg P, Thiele H, Altmüller J, Toliat MR, Staubach S, Boycott KM, Valente EM, Janecke AR, Eisenberger T, Bergmann C, Tebbe L, Wang Y, Wu Y, Fry AM, Westerfield M, Wolfrum U, Bolz HJ (2014). Mutation of POC1B in a severe syndromic retinal ciliopathy. Hum Mutat. 35, 1153-1162
    • Borck G, de Vries L, Wu HJ, Smirin-Yosef P, Nürnberg G, Lagovsky I, Ishida LH, Thierry P, Wieczorek D, Nürnberg P, Foley J, Kubisch C, Basel-Vanagaite L (2014). Homozygous truncating PTPRF mutation causes athelia. Hum Genet. 133, 1041-1047
    • Breitenkamp AF, Matthes J, Nass RD, Sinzig J, Lehmkuhl G, Nürnberg P, Herzig S (2014). Rare mutations of CACNB2 found in autism spectrum disease-affected families alter calcium channel function. PLoS ONE. 9, e95579
    • Cunha DL, Eckl KM, Rauch M, Casper R, Gupta M, Nürnberg P, Schmuth M, Zschocke J, Saric T, Hennies HC (2014). Generation and characterization of induced Pluripotent Stem (iPS) cells from Autosomal Recessive Congenital Ichthyosis patients - a new model system to study rare keratinization disorders. J Invest Dermatol. 134, S34-S34
    • Dejanovic B, Lal D, Catarino CB, Arjune S, Belaidi AA, Trucks H, Vollmar C, Surges R, Kunz WS, Motameny S, Altmüller J, Köhler A, Neubauer BA, Epicure C, Nürnberg P, Noachtar S, Schwarz G, Sander T (2014). Exonic microdeletions of the gephyrin gene impair GABAergic synaptic inhibition in patients with idiopathic generalized epilepsy. Neurobiol Dis. 67, 88-96
    • Doss S, Lohmann K, Seibler P, Arns B, Klopstock T, Zühlke C, Freimann K, Winkler S, Lohnau T, Drungowski M, Nürnberg P, Wiegers K, Lohmann E, Naz S, Kasten M, Bohner G, Ramirez A, Endres M, Klein C (2014). Recessive dystonia-ataxia syndrome in a Turkish family caused by a COX20 (FAM36A) mutation. J Neurol. 261, 207-212
    • Ehmke N, Caliebe A, Koenig R, Kant SG, Stark Z, Cormier-Daire V, Wieczorek D, Gillessen-Kaesbach G, Hoff K, Kawalia A, Thiele H, Altmüller J, Fischer-Zirnsak B, Knaus A, Zhu N, Heinrich V, Huber C, Harabula I, Spielmann M, Horn D, Kornak U, Hecht J, Krawitz PM, Nürnberg P, Siebert R, Manzke H, Mundlos S (2014). Homozygous and compound-heterozygous mutations in TGDS cause Catel-Manzke syndrome. Am J Hum Genet. 95, 763-770
    • Elsayed SM, Heller R, Thoenes M, Zaki MS, Swan D, Elsobky E, Zühlke C, Ebermann I, Nürnberg G, Nürnberg P, Bolz HJ (2014). Autosomal dominant SCA5 and autosomal recessive infantile SCA are allelic conditions resulting from SPTBN2 mutations. Eur J Hum Genet. 22, 286-288
    • Fernandez-Cuesta L, Peifer M, Lu X, Sun R, Ozreti L, Seidel D, Zander T, Leenders F, George J, Müller C, Dahmen I, Pinther B, Bosco G, Konrad K, Altmüller J, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soltermann A, Brustugun OT, Helland Å, Solberg S, Lund-Iversen M, Ansén S, Stoelben E, Wright GM, Russell P, Wainer Z, Solomon B, Field JK, Hyde R, Davies MP, Heukamp LC, Petersen I, Perner S, Lovly CM, Cappuzzo F, Travis WD, Wolf J, Vingron M, Brambilla E, Haas SA, Buettner R, Thomas RK (2014). Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nat Commun. 5, 3518
    • Fernandez-Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, Daßler J, Malchers F, Schöttle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, Brambilla E, Nagy-Mignotte H, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Altmüller J, Becker C, Nürnberg P, Heuckmann JM, Stoelben E, Petersen I, Clement JH, Sänger J, Muscarella LA, la Torre A, Fazio VM, Lahortiga I, Perera T, Ogata S, Parade M, Brehmer D, Vingron M, Heukamp LC, Buettner R, Zander T, Wolf J, Perner S, Ansén S, Haas SA, Yatabe Y, Thomas RK (2014). CD74-NRG1 Fusions in Lung Adenocarcinoma. Cancer Discov. 4, 415-422
    • Gee HY, Otto EA, Hurd TW, Ashraf S, Chaki M, Cluckey A, Vega-Warner V, Saisawat P, Diaz KA, Fang H, Kohl S, Allen SJ, Airik R, Zhou W, Ramaswami G, Janssen S, Fu C, Innis JL, Weber S, Vester U, Davis EE, Katsanis N, Fathy HM, Jeck N, Klaus G, Nayir A, Rahim KA, Al Attrach I, Al Hassoun I, Ozturk S, Drozdz D, Helmchen U, O'Toole JF, Attanasio M, Lewis RA, Nürnberg G, Nürnberg P, Washburn J, MacDonald J, Innis JW, Levy S, Hildebrandt F (2014). Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies. Kidney Int. 85, 880-887
    • Haghighi A, Tiwari A, Piri N, Nürnberg G, Saleh-Gohari N, Neidhardt J, Nürnberg P, Berger W (2014). Homozygosity mapping and whole exome sequencing reveal a novel homozygous COL18A1 mutation causing Knobloch syndrome. PLoS ONE. 9, e112747
    • Hallmann K, Zsurka G, Moskau-Hartmann S, Kirschner J, Korinthenberg R, Ruppert AK, Ozdemir O, Weber Y, Becker F, Lerche H, Elger CE, Thiele H, Nürnberg P, Sander T, Kunz WS (2014). A homozygous splice-site mutation in CARS2 is associated with progressive myoclonic epilepsy. Neurology. 83, 2183-2187
    • Hussain MS, Battaglia A, Szczepanski S, Kaygusuz E, Toliat MR, Sakakibara S, Altmüller J, Thiele H, Nürnberg G, Moosa S, Yigit G, Beleggia F, Tinschert S, Clayton-Smith J, Vasudevan P, Urquhart JE, Donnai D, Fryer A, Percin F, Brancati F, Dobbie A, Smigiel R, Gillessen-Kaesbach G, Wollnik B, Noegel AA, Newman WG, Nürnberg P (2014). Mutations in CKAP2L, the human homolog of the mouse Radmis gene, cause Filippi syndrome. Am J Hum Genet. 95, 622-632
    • Ikram F, Ackermann S, Roels E, Volland R, Hero B, Hertwig F, Kocak H, Dreidax D, Henrich KO, Berthold F, Nürnberg P, Westermann F, Fischer M (2014). Transcription factor activating protein 2 beta (TFAP2B) mediates neuronal differentiation in neuroblastoma. Eur J Cancer. 50 6, 130-131
    • Khan MA, Rupp VM, Orpinell M, Hussain MS, Altmüller J, Steinmetz MO, Enzinger C, Thiele H, Höhne W, Nürnberg G, Baig SM, Ansar M, Nürnberg P, Vincent JB, Speicher MR, Gönczy P, Windpassinger C (2014). A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family. Hum Mol Genet. 23, 5940-5949
    • Lal D, Reinthaler EM, Schubert J, Muhle H, Riesch E, Kluger G, Jabbari K, Kawalia A, Bäumel C, Holthausen H, Hahn A, Feucht M, Neophytou B, Haberlandt E, Becker F, Altmüller J, Thiele H, Lemke JR, Lerche H, Nürnberg P, Sander T, Weber Y, Zimprich F, Neubauer BA (2014). DEPDC5 mutations in genetic focal epilepsies of childhood. Ann Neurol. 75, 788-792
    • Lessel D, Saha B, Hisama F, Kaymakamzade B, Nurlu G, Gursoy-Özdemir Y, Thiele H, Nürnberg P, Martin GM, Kubisch C, Oshima J (2014). Atypical Aicardi-Goutieres syndrome: is the WRN locus a modifier? Am J Med Genet A. 164A, 2510-2513
    • Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, Altmüller J, Nürnberg G, Nürnberg P, Bahlo M, Martin GM, Aalfs CM, Oshima J, Terzic J, Amor DJ, Dikic I, Ramadan K, Kubisch C (2014). Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat Genet. 46, 1239-1244
    • Mansfield C, Buyandelger B, Kostin S, Knoell G, Toliat MR, Perrot A, Haverkamp W, Milting H, Nürnberg P, Knoell R (2014). The role of MIP1 in cardiac myocyte hypertrophy and survival. Cardiovasc Res. 103 1
    • Martin CA, Ahmad I, Klingseisen A, Hussain MS, Bicknell LS, Leitch A, Nürnberg G, Toliat MR, Murray JE, Hunt D, Khan F, Ali Z, Tinschert S, Ding J, Keith C, Harley ME, Heyn P, Müller R, Hoffmann I, Daire VC, Dollfus H, Dupuis L, Bashamboo A, McElreavey K, Kariminejad A, Mendoza-Londono R, Moore AT, Saggar A, Schlechter C, Weleber R, Thiele H, Altmüller J, Höhne W, Hurles ME, Noegel AA, Baig SM, Nürnberg P, Jackson AP (2014). Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet. 46, 1283-1292
    • Morin G, Bruechle NO, Singh AR, Knopp C, Jedraszak G, Elbracht M, Brémond-Gignac D, Hartmann K, Sevestre H, Deutz P, Hérent D, Nürnberg P, Roméo B, Konrad K, Mathieu-Dramard M, Oldenburg J, Bourges-Petit E, Shen Y, Zerres K, Ouadid-Ahidouch H, Rochette J (2014). Gain-of-Function Mutation in STIM1 (P.R304W) Is Associated with Stormorken Syndrome. Hum Mutat. 35, 1221-1232
    • Murray JE, Bicknell LS, Yigit G, Duker AL, van Kogelenberg M, Haghayegh S, Wieczorek D, Kayserili H, Albert MH, Wise CA, Brandon J, Kleefstra T, Warris A, van der Flier M, Bamforth JS, Doonanco K, Adès L, Ma A, Field M, Johnson D, Shackley F, Firth H, Woods CG, Nürnberg P, Gatti RA, Hurles M, Bober MB, Wollnik B, Jackson AP (2014). Extreme growth failure is a common presentation of ligase IV deficiency. Hum Mutat. 35, 76-85
    • Portelli MA, Siedlinski M, Stewart CE, Postma DS, Nieuwenhuis MA, Vonk JM, Nürnberg P, Altmuller J, Moffatt MF, Wardlaw AJ, Parker SG, Connolly MJ, Koppelman GH, Sayers I (2014). Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels. FASEB J. 28, 923-934
    • Quednow BB, Ramirez A, Nürnberg P, Waha A, Maier W, Winterer G, Wagner M (2014). Is the Interaction of Smoking with TCF4 Schizophrenia Risk Alleles on the Disruption of Sensory Gating Explained by Epigenetic Mechanisms? Biol Psychiatry. 75 S, 294S-294S
    • Reinthaler EM, Lal D, Jurkowski W, Feucht M, Steinböck H, Gruber-Sedlmayr U, Ronen GM, Geldner J, Haberlandt E, Neophytou B, Hahn A, Altmüller J, Thiele H, Toliat MR, Euro EC, Lerche H, Nürnberg P, Sander T, Neubauer BA, Zimprich F (2014). Analysis of ELP4, SRPX2, and interacting genes in typical and atypical rolandic epilepsy. Epilepsia. 55, e89-93
    • Reinthaler EM, Lal D, Lebon S, Hildebrand MS, Dahl HH, Regan BM, Feucht M, Steinböck H, Neophytou B, Ronen GM, Roche L, Gruber-Sedlmayr U, Geldner J, Haberlandt E, Hoffmann P, Herms S, Gieger C, Waldenberger M, Franke A, Wittig M, Schoch S, Becker AJ, Hahn A, Männik K, Toliat MR, Winterer G, p11.2 European C, Lerche H, Nürnberg P, Mefford H, Scheffer IE, Berkovic SF, Beckmann JS, Consortium E, Euro EC, Sander T, Jacquemont S, Reymond A, Zimprich F, Neubauer BA, Neubauer B, Mörzinger M, Suls A, Weckhuysen S, Claes L, Deprez L, Smets K, Van Dyck T, Deconinck T, De Jonghe P, Møller RS, Klitten LL, Hjalgrim H, Campus K, Helbig I, Muhle H, Ostertag P, von Spiczak S, Stephani U, Trucks H, Elger CE, Kleefuß-Lie AA, Kunz WS, Surges R, Gaus V, Janz D, Schmitz B, Rosenow F, Klein KM, Reif PS, Oertel WH, Hamer HM, Becker F, Weber Y, Koeleman BP, de Kovel C, Lindhout D, Ameil A, Andrieux J, Bouquillon S, Boute O, Cordier MP, Cuisset JM, Cuvellier JC, David A, de Vries B, Delrue MA, Doco-Fenzy M, Fernandez BA, Heron D, Keren B, Lebel R, Leheup B, Lewis S, Mencarelli MA, Mignot C, Minet JC, Moerman A, Morice-Picard F, Mucciolo M, Ounap K, Pasquier L, Petit F, Ragona F, Rajcan-Separovic E, Renieri A, Rieubland C, Sanlaville D, Sarrazin E, Shen Y, van Haelst M, Vulto-van Silfhout A (2014). 16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy. Hum Mol Genet. 23, 6069-6080
    • Schreml J, Durmaz B, Cogulu O, Keupp K, Beleggia F, Pohl E, Milz E, Coker M, Ucar SK, Nürnberg G, Nürnberg P, Kuhn J, Ozkinay F (2014). The missing "link": an autosomal recessive short stature syndrome caused by a hypofunctional XYLT1 mutation. Hum Genet. 133, 29-39
    • Schubert J, Siekierska A, Langlois M, May P, Huneau C, Becker F, Muhle H, Suls A, Lemke JR, de Kovel CG, Thiele H, Konrad K, Kawalia A, Toliat MR, Sander T, Rüschendorf F, Caliebe A, Nagel I, Kohl B, Kecskés A, Jacmin M, Hardies K, Weckhuysen S, Riesch E, Dorn T, Brilstra EH, Baulac S, Møller RS, Hjalgrim H, Koeleman BP, Euro ERESC, Jurkat-Rott K, Lehman-Horn F, Roach JC, Glusman G, Hood L, Galas DJ, Martin B, de Witte PA, Biskup S, De Jonghe P, Helbig I, Balling R, Nürnberg P, Crawford AD, Esguerra CV, Weber YG, Lerche H (2014). Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes. Nat Genet. 46, 1327-1332
    • Smolonska J, Koppelman GH, Wijmenga C, Vonk JM, Zanen P, Bruinenberg M, Curjuric I, Imboden M, Thun GA, Franke L, Probst-Hensch NM, Nürnberg P, Riemersma RA, van Schayck CP, Loth DW, Brusselle GG, Stricker BH, Hofman A, Uitterlinden AG, Lahousse L, London SJ, Loehr LR, Manichaikul A, Barr RG, Donohue KM, Rich SS, Pare P, Bossé Y, Hao K, van den Berge M, Groen HJ, Lammers JW, Mali W, Boezen HM, Postma DS (2014). Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis. Eur Respir J. 44, 860-872

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    Linda Partridge

    • Alic N, Tullet JM, Niccoli T, Broughton S, Hoddinott MP, Slack C, Gems D, Partridge L (2014). Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging. Cell Rep. 2014 Feb 27;6(4):608-16. doi: 10.1016/j.celrep.2014.01.015. Epub 2014 Feb 6
    • Alic N, Giannakou ME, Papatheodorou I, Hoddinott MP, Andrews TD, Bolukbasi E, Partridge L (2014). Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster. PLoS Genetics. 10, e1004619
    • Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG (2014). Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.  Nucleic Acids Res. 42, 13920-13938
    • Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC (2014). Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nature Immunol. 15, 423-430
    • Metaxakis A, Tain LS, Grönke S, Hendrich O, Hinze Y, Birmas U, Partridge L (2014). Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila. PLoS Biol. 12, e1001824
    • Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IO, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EM, Partridge L, Isaacs AM (2014). C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science. 345, 1192-1194
    • Partridge L (2014). Intervening in ageing to prevent the diseases of ageing. Trends Endocrinol Metab. 25, 555-557
    • Partridge L (2014). Editorial 2014. Philos Trans R Soc Lond B Biol Sci. 369, 20130496
    • Piper MD, Blanc E, Leitão-Gonçalves R, Yang M, He X, Linford NJ, Hoddinott MP, Hopfen C, Soultoukis GA, Niemeyer C, Kerr F, Pletcher SD, Ribeiro C, Partridge L (2014). A holidic medium for Drosophila melanogaster. Nat Methods. 2014 Jan;11(1):100-5. doi: 10.1038/nmeth.2731. Epub 2013 Nov 17
    • Piper MD, Selman C, Speakman JR, Partridge L (2014). Using doubly-labeled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster. J Genet Genomics.41, 505-512
    • Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J, Partridge L (2014). Lithium suppresses Abeta pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease. Front Aging Neurosci.6, 190

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    Manolis Pasparakis                                               

    • Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jöckel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers MA, Trumpp A (2014). Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J Exp Med. 211(5):769-79
    • Dan HC, Ebbs A, Pasparakis M, Van Dyke T, Basseres DS, Baldwin AS (2014). Akt-Dependent Activation of mTORC1 Involves Phosphorylation of mTOR by IKKalpha. J Biol Chem. 289(36):25227-40
    • Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M (2014). RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 513(7516):90-4
    • Eguether T, Ermolaeva MA, Zhao Y, Bonnet MC, Jain A, Pasparakis M, Courtois G, Tassen AM (2014). The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nat Commun. 5:4585
    • Ehlken H, Krishna-Subramanian S, Ochoa-Callejero L, Kondylis V, Nadi NE, Straub BK, Schirmacher P, Walczak H, Kollias G, Pasparakis M (2014). Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO Knockout. Cell Death Differ. 21(11):1721-32
    • Heise N, De Silva NS, Silva K, Carette A, Simonetti G, Pasparakis M, Klein U (2104). Germinal center B cell maintenance and differentiation are controlled by distinct NF-kB transcription factor subunits. J Exp Med. 211(10):2103-18  
    • Kim C, Pasparakis M (2014). Epidermal p65/NF-kB signalling is essential for skin carcinogenesis. EMBO Mol Med. 6(7):970-83
    • Kim C, Pasparakis M (2014). RIP kinase 3 in necroptosis: does it take two or more to kill? Cell Death Differ. 21: 1505-7    
    • Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikea F (2014). Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. elife. 2014 Dec 2;3
    • Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S (2014). Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A. 111(47):16836-41
    • Liu Y, Liu X, Hao W, Decker Y, Schomburg R, Fülöp L, Pasparakis M, Menger MD, Fassbender K (2014). IKKß deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology. J Neurosci. 34(39):12982-99   
    • Lu H, Lu Q, Gaddipati S, Kasetti RB, Wang W, Pasparakis M, Kaplan HJ, Li Q (2014). IKK2 inhibition attenuates laser-induced choroidal neovascularization. PLoS One. 9(1):e87530
    • Pasparakis M, Haase I, Nestle FO (2014). Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol. 14(5):289-301 
    • Polykratis A, Hermance N, Zelic M, Roderick J, Kim C, Van TM, Lee TH, Chan FK, Pasparakis M, Kelliher MA (2014). Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo. J Immunol. 193(4):1539-43
    • Roderick JE, Hermance N, Zelic M, Simmons MJ, Polykratis A, Pasparakis M, Kelliher MA (2014). Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis. Proc Natl Acad Sci U S A. 111(40):14436-41
    • Saliba DG, Heger A, Eames HL, Oikonomopoulos S, Teixeira A, Blazek K, Androulidaki A, Wong D, Goh FG, Weiss M, Byrne A, Pasparakis M, Ragoussis J, Udalova IA (2014). IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages. Cell Rep. 8(5):1308-17
    • Srivastava K, Hu J, Korn C, Savant S, Teichert M, Kapel SS, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG (2014). Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell. 26(6):880-95 

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    Mats Paulsson

    • Becker AK, Mikolajek H, Paulsson M, Wagener R, Werner JM (2014). A Structure of a Collagen VI VWA Domain Displays N and C Termini at Opposite Sides of the Protein. Structure. 2014 Feb 4;22(2):199-208. doi: 10.1016/j.str.2013.06.028. Epub 2013 Dec 12
    • Bognar P, Nemeth I, Mayer B, Haluszka D, Wikonkal N, Ostorhazi E, John S, Paulsson M, Smyth N, Pasztoi M, Buzas EI, Szipocs R, Kolonics A, Temesvari E, Karpati S (2014). Reduced inflammatory threshold indicates skin barrier defect in transglutaminase 3 knockout mice. J Invest Dermatol. 2014 Jan;134(1):105-11. doi: 10.1038/jid.2013.307. Epub 2013 Jul 24
    • Franko A, Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, Angelis MH, Paulsson M, Schubert M, Wiesner RJ (2014). Liver adapts mitochondrial function to insulin resistant and diabetic states in mice. J Hepatol. 60, 816-823
    • Lettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R (2014). Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies. Expression of classical and novel collagen VI variants during wound healing. PLoS One. 9, e105686
    • Neacsu CD, Ko YP, Tagariello A, Røkenes Karlsen K, Neiss WF, Paulsson M, Wagener R (2014). Matrilin-1 is essential for zebrafish development by facilitating collagen II secretion. J Biol Chem. 2014 Jan 17;289(3):1505-18. doi: 10.1074/jbc.M113.529933. Epub 2013 Nov 29
    • Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Rökenes Karlsen K, Richetti S, Wohl A, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R (2014). AMACO is a component of the basement membrane associated Fraser complex. J Invest Dermatol. 134, 1313-1322
    • Semkova I, Kociok N, Karagiannis D, Nischt R, Smyth N, Paulsson M, Strauß O, Joussen AM (2014). Anti-angiogenic effect of the basement membrane protein nidogen-1 in a mouse model of choroidal neovascularization. Exp Eye Res. 2014 Jan;118:80-8. doi: 10.1016/j.exer.2013.11.006. Epub 2013 Nov 23
    • Tagliavini F, Pellegrini C, Sardone F, Suarzoni S, Paulsson M, Wagener R, Gualandi F, Ferlini A, Merlini L, Santi S, Maraldi NM, Faldini C, Sabatelli P (2014). Defective collagen VI a6 chain expression in the skeletal muscle of patients with collagen VI-related myopathies. BBA-Mol Basis Dis. 1842, 1604-1612 

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    Alvaro Rada-Iglesias

    • Rada-Iglesias A (2014). Genetic variation within transcriptional regulatory elements and its implications for human disease. Biol Chem. 2014 Dec 1;395(12):1453-60. PMID:25205712

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    Hans Christian Reinhardt

    • Dietlein F, Thelen L, Jokic M, Jachimowicz RD, Ivan L, Knittel G, Leeser U, van Oers J, Edelmann W, Heukamp LC, Reinhardt HC (2014). A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC. Cancer Discovery. 2014 May;4(5):592-605
    • Dietlein F, Reinhardt HC (2014). Molecular Pathways: Exploiting cancer-specific defects in homology-mediated DNA repair for personalized therapy. Clin Canc Res. 2014 Dec 1;20(23):5882-7
    • Dietlein F, Thelen L, Reinhardt HC (2014). Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches. TRENDS in Genetics. 2014 Jul 10. 2014 Aug;30(8):326-39
    • Franke M, Reinhardt HC, von Bergwelt-Baildon M, Bangard C (2014). Massive air embolism following lung biopsy. Circulation. 2014 Mar 4;129(9):1046-7

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    Nirmal Robinson

    • Persa OD, Jazmati N, Robinson N, Wolke M, Kremer K, Schweer K, Plum G, Schlaak M (2014). A pregnant woman with chronic meningococcaemia from Neisseria meningitidis with lpxL1-mutations. Lancet. 384(9957). Epub Nov 21

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    Elena I. Rugarli

    • Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T (2014). The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol. 2014, 204:919-29
    • Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli E, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H (2014). BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 33:2171-87. doi: 10.15252/embj.201387244
    • Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli E, Trifunovic A (2014). Tissue-specific loss of Dars2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab. 19(3):458-69
    • Gao J, Schatton D, Martinelli P, Hansen H, Pla-Martin D, Barth E, Becker C, Altmueller J, Frommolt P, Sardiello M, Rugarli E (2014). CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins. J Cell Biol. 207(2):213-23. doi: 10.1083/jcb.201403129
    • Kondadi AK, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, Herholz D, Baker MJ, Schauss AC, Langer T, Rugarli E (2014). Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 33(9):1011-26
    • Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli E, Langer T (2014). DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling. Cell Metab. 20:158-71. doi: 10.1016/j.cmet.2014.04.016
    • Smets K, Deconinck T, Baets J, Sieben A, Martin JJ, Smouts I, Wang S, Taroni F, Di Bella D, Van Hecke W, Parizel PM, Jadoul C, De Potter R, Couvreur F, Rugarli E, De Jonghe P (2014). A partial deletion of AFG3L2 causing spinocerebellar ataxia type 28. Neurology. 82: 2092-100. doi: 10.1212/WNL.0000000000000491

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      Bernhard Schermer

      • Borgal L, Rinschen M, Dafinger C, Hoff S, Reinert M, Lamkemeyer T, Lienkamp S, Benzing T, Schermer B (2014). Casein kinase 1 ? phosphorylates the Wnt regulator Jade-1 and modulates its activity. J Biol Chem. 289: 26344–56
      • Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke S, Dryer S, Schermer B, Benzing T, Benzing T, Brinkkoetter P (2014). Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J. 28: 1769–79
      • Hagmann H, Bossung V, Belaidi A, Fridman A, Karumanchi S, Thadhani R, Schermer B, Mallmann P, Schwarz G, Benzing T, Brinkkoetter P (2014). Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination. PLoS ONE. 9: e85258
      • Kohli P, Bartram M, Habbig S, Pahmeyer C, Lamkemeyer T, Benzing T, Schermer B, Rinschen M (2014). Label-free quantitative proteomic analysis of the YAP/TAZ interactome. Am J Physiol Cell Physiol. 306: C805-18
      • Kurschat C, Müller R, Franke M, Maintz D, Schermer B, Benzing T (2014). An approach to cystic kidney diseases: the clinician’s view. Nat Rev Nephrol. 10: 687–99
      • Mueller M, Castells-Roca L, Babu V, Ermolaeva M, Müller R, Frommolt P, Williams A, Greiss S, Schneider J, Benzing T, Schermer B, Schumacher B, Schumacher B (2014). DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 16: 1168–79
      • Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks B, Beltrao P, Krueger M, Brinkkoetter P, Benzing T (2014). Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol. 25: 1509–22
      • Rinschen MM, Schermer B, Benzing T (2014). Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again. J Am Soc Nephrol. 25: 1140–7
      • Schurek E, Völker L, Tax J, Lamkemeyer T, Rinschen M, Ungrue D, Kratz J, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, Höhne M (2014). A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin. J Biol Chem. 289: 11262–71
      • Talbot J, Song X, Wang X, Rinschen M, Doerr N, LaRiviere W, Schermer B, Pei Y, Torres V, Weibs T (2014). The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol. 25: 1737–48, 2014

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      Björn Schumacher

      • Babu V, Hofmann K, Schumacher B (2014). A C. elegans homolog of the Cockayne syndrome complementation group A gene. DNA Repair. 2014 Dec:24:57-62. doi: 10.1016/j.dnarep.2014.09.012
      • Behrens A, van Deursen J, Rudolph KL, Schumacher B (2014). Impact of genomic damage and ageing on stem cell function. Nat Cell Biol. 2014 Feb 28;16(3):201-7. doi: 10.1038/ncb2928
      • Ermolaeva MA, Schumacher B (2014). Insights from the worm: The C. elegans model for innate immunity. Semin Immunol. 2014 May 20. pii: S1044-5323(14)00051-7. doi: 10.1016/j.smim.2014.04.005
      • Ermolaeva M, Schumacher B (2014). Systemic DNA damage responses: Organismal adaptations to genome instability. Trends Genet. 2014 Mar;30(3):95-102. doi: 10.1016/j.tig.2013.12.001
      • Mueller M, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B (2014). DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 2014 Nov 24:16(12):1168–1179. doi: 10.1038/ncb3071
      • Nkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P, Schumacher B (2014). Proteome analysis in the assessment of ageing. Ageing Res Rev. 2014 Sep 22. pii: S1568-1637(14)00105-6. doi:10.1016/j.arr.2014.09.002
      • Wolters S, Ermolaeva M, Bickel J, Fingerhut J, Khanikar J, Chan R, Schumacher B (2014). Loss of C. elegans BRCA1 promotes genome stability during replication in smc-5 mutants.Genetics. 2014 Apr;196(4):985-99. doi: 10.1534/genetics.113.158295

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      Günter Schwarz

      • Dejanovic B, Lal D, Catarino CB, Arjune S, Belaidi AA, Trucks H, Vollmar C, Surges R, Kunz WS, Motameny S, Altmüller J, Köhler A, Neubauer BA, Epicure Consortium, Nürnberg P, Noachtar S, Schwarz G, Sander T (2014). Exonic microdeletions of the gephyrin gene impair GABAergic synaptic inhibition in patients with idiopathic generalized epilepsy. Neurobiol Dis. Feb 19. pii: S0969-9961(14)00036-9. doi: 10.1016/j.nbd.2014.02.001. Epub 2014 Feb 19
      • Dejanovic B, Semtner M, Ebert S, Lamkemeyer T, Neuser F, Lüscher B, Meier JC, Schwarz G (2014). Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. PLoS Biol. 2014 Jul 15;12(7):e1001908. doi: 10.1371/journal.pbio.1001908
      • Dejanovic B, Schwarz G (2014). Neuronal nitric oxide synthase-dependent S-nitrosylation of gephyrin regulates gephyrin. J Neurosci. 2014 Jun 4;34(23):7763-8. doi: 10.1523/JNEUROSCI.0531-14.2014
      • Fröhlich M, Dejanovic B, Kashkar H, Schwarz G, Nussberger S (2014). S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Cell Death Dis. 5, e1057
      • Hagmann H, Bossung V, Belaidi AA, Fridman A, Karumanchi SA, Thadhani R, Schermer B, Mallmann P, Schwarz G, Benzing T, Brinkkoetter PT (2014). Low-Molecular Weight Heparin Increases Circulating sFlt-1 Levels and Enhances Urinary Elimination. PLoS One. 9: e85258
      • Havarushka N, Fischer-Schrader K, Lamkemeyer T, Schwarz G (2014). Structural Basis of Thermal Stability of the Tungsten Cofactor Synthesis Protein MoaB from Pyrococcus furiosus. PLoS One. 9:e86030
      • Kalimuthu P, Fischer-Schrader K, Schwarz G, Bernhardt PV (2014). A sensitive and stable amperometric nitrate biosensor employing Arabidopsis thaliana nitrate reductase. J Biol Inorg Chem. 20: 385. Epub 2014 Jul 2
      • Keusekotten K, Bade VN, Meyer-Teschendorf K, Sriramachandran AM, Fischer-Schrader K, Krause A, Horst C, Schwarz G, Hofmann K, Dohmen RJ, Praefcke GJ (2014). Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO. Biochem J. Jan 1;457(1):207-14. doi: 10.1042/BJ20130753
      • Klein EL, Belaidi AA, Raitsimring AM, Davis AC, Krämer T, Astashkin AV, Neese F, Schwarz G, Enemark JH (2014). Pulsed electron paramagnetic resonance spectroscopy of (33)S-labeled molybdenum cofactor in catalytically active bioengineered sulfite oxidase. Inorg Chem. Jan 21;53(2):961-71. doi: 10.1021/ic4023954. Epub 2014 Jan 3
      • Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Häussler U, Jüttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC (2014). Changes in neural network homeostasis trigger neuropsychiatric symptoms. J Clin Invest. Feb 3;124(2):696-711. doi: 10.1172/JCI71472. Epub 2014 Jan 16

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      Wilhelm Stoffel

      • Stoffel W, Hammels I, Jenke B, Binczek E, Schmidt-Soltau I, Brodesser S, Odenthal M, Thevis M (2014). Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. EMBO Rep. 2014 Jan;15(1):110-20. doi: 10.1002/embr.201338041. Epub 2013 Dec 30

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      Peter Tessarz

      • Tessarz P, Kouzarides T (2014). Histone core modifications regulating nucleosome structure and dynamics. Nature Rev Mol Cell Biol. (15): 703-708
      • Tessarz P, Santos-Rosa H, Robson SC, Sylvestersen KB, Nelson CJ, Nielsen ML, Kouzarides T (2014). Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature. 505, 564–568

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      Aleksandra Trifunovic

      • Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H (2014).Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med. 2014 May 1;6(5):624-39
      • Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A (2014). Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab. 2014 Mar 4;19(3):458-69
      • Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A (2014). Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity. PLoS Genet. 2014 Jun 19;10(6):e1004385
      • Li L, Trifunovic A, Köhler M, Wang Y, Berglund JP, Illies C, Juntti-Berggren L, Larsson NG, Berggren PO (2014). Defects in β-Cell Ca2+ Dynamics in Age-Induced Diabetes. Diabetes. 2014 Jul 1. pii: DB_131855
      • Trifunovic A, Ventura N (2014). Mitochondria and metabolic control of the aging process. Exp Gerontol. 2014 Aug;56:1-2
      • Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC (2014). Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance. Cell Metab. 2014 Oct 7;20(4):678-86

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      Mirka Uhlirova

      • Claudius A, Romani P, Lamkemeyer T, Jindra M, Uhlirova M (2014). Unexpected Role of the Steroid-Deficiency Protein Ecdysoneless in Pre-mRNA Splicing. PLOS Genet. 10: e1004287

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      Dario Valenzano

      • Ciocca G, Limoncin E, Cellerino A, Fisher AD, Gravina GL, Carosa E, Mollaioli D, Valenzano DR, Mennucci A, Bandini E, Di Stasi S, Maggi M, Lenzi A, Jannini E (2014). Gender identity rather than sexual orientation impacts on facial preferences. The Journal of Sexual Medicine. 11 (10), 2500-2507

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      David Vilchez

      • Saez I, Vilchez D (2014).The mechanistic links between proteasome activity, aging and age-related diseases. Current Genomics. 15(1): 38-51
      • Vilchez D, SimicM, Dillin A (2014). Proteostasis and aging of stem cells. Trends in Cell Biology. 24(3): 161-170
      • Vilchez D, Saez I, Dillin A (2014).The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nature Communications. 5: 5659

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      Sara Wickström

      • Eckes B, Krieg T, Wickström SA (2014). Role of integrin signaling through Integrin-linked kinase (ILK) in skin physiology and pathology. Exp Dermatol. 23, 453-456
      • Schiefermeier N, Scheffler J, de Araujo MEG, Stasyk T, Teis D, Li Z, Ebner HL, Offterdinger M, Munck S, Hess MW, Wickström SA, Lange A, Wunderlich W, Sacks DB, Fassler R, Huber LA (2014). The late endosomal p14/MP1 (Lamtor2/3) complex regulates focal adhesion dynamics during cell migration. J Cell Biol. 205, 525-540

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      Rudolf J. Wiesner

      • Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H (2014). Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med. 6, 624-39
      • Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stöhr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, Hrabĕ de Angelis M, PaulssonM, Schubert M, Wiesner RJ (2014). Liver adapts mitochondrial function to insulin resistant and diabetic states in mice. J Hepatol. 60, 816-823
      • Kozieł R, Ruckenstuhl C, Albertini E, Neuhaus M, Netzberger C, Bust M, Madeo F, Wiesner RJ, Jansen-Dürr P (2014). Methionine restriction slows down senescence in human diploid fibroblasts. Aging Cell. 13, 1038-48
      • Neuhaus JFG, Baris OR, Hess S, Moser N, Schröder HJ, Chinta SJ, Andersen JK, Kloppenburg P, Wiesner RJ (2014). Catecholamine Metabolism Drives the Generation of Mitochondrial DNA Deletions in Dopaminergic Neurons. Brain. 137:354-65

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      Andreas Wodarz

      • Linnemannstöns K, Ripp C, Honemann-Capito M, Brechtel-Curth K, Hedderich M, Wodarz A (2014). The PTK7-related transmembrane proteins Off-track and Off-track2 are co-receptors for Drosophila Wnt2 required for male fertility. PLoS Genetics. 10, e1004443

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      Bernd Wollnik

      • Murray JE, Bicknell LS, Yigit G, Duker AL, van Kogelenberg M, Haghayegh S, Wieczorek D, Kayserili H, Albert MH, Wise CA, Brandon J, Kleefstra T, Warris A, van der Flier M, Bamforth JS, Doonanco K, Adès L, Ma A, Field M, Johnson D, Shackley F, Firth H, Woods CG, Nürnberg P, Gatti RA, Hurles M, Bober MB, Wollnik B, Jackson AP (2014). Extreme growth failure is a common presentation of ligase IV deficiency. Hum Mutat. 2014 Jan;35(1):76-85. doi: 10.1002/humu.22461. Epub 2013 Nov 8

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      Thomas Wunderlich

      • Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H (2014). BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 2014 Oct 1;33(19):2171-87
      • Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A (2014). IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions. J Invest Dermatol. 2014 Mar;134(3):728-35
      • Geibel M, Badurek S, Horn JM, Vatanashevanopakorn C, Koudelka J, Wunderlich CM, Brönneke HS, Wunderlich FT, Minichiello L (2014). Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity. Nat Commun. 2014 Mar 12;5:3427
      • Lepperhof V, Polchynski O, Kruttwig K, Brüggemann C, Neef K, Drey F, Zheng Y, Ackermann JP, Choi YH, Wunderlich TF, Hoehn M, Hescheler J, Sarić T (2014). Bioluminescent imaging of genetically selected induced pluripotent stem cell-derived cardiomyocytes after transplantation into infarcted heart of syngeneic recipients. PLoS One. 2014 Sep 16;9(9):e107363
      • Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC (2014). Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol. 2014 May;15(5):423-30
      • Nish SA, Schenten D, Wunderlich FT, Pope SD, Gao Y, Hoshi N, Yu S, Yan X, Lee HK, Pasman L, Brodsky I, Yordy B, Zhao H, Brüning J, Medzhitov R (2014). T cell-intrinsic role of IL-6 signaling in primary and memory responses. Elife. 2014 May 19;3:e01949
      • Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, Medzhitov R (2014). Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Immunity. 2014 Jan 16;40(1):78-90
      • Sommer D, Peters A, Wirtz T, Mai M, Ackermann J, Thabet Y, Schmidt J, Weighardt H, Wunderlich FT, Degen J, Schultze JL, Beyer M (2014). Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nat Commun. 2014;5:3045
      • Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brönneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brüning JC (2014). Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. Cell Rep. 2014 Nov 20;9(4):1495-506
      • Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC (2014). Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 2014 Oct 7;20(4):678-86

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      Branko Zevnik

      • Zevnik B, Uyttersprot NC, Perez AV, Bothe GWM, Kern H, Kauselmann G (2014). C57BL/6N Albino/Agouti Mutant Mice as Embryo Donors for Efficient Germline Transmission of C57BL/6 ES Cells. PLoS ONE. 9(3): e90570. doi: 10.1371/journal.pone.0090570

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