Publications 2020

Adam Antebi

  • A Coch R, Geisler F, Annibal A, Antebi A, E Leube R (2020). Identification of A Novel Link between the Intermediate Filament Organizer IFO-1 and Cholesterol Metabolism in the Caenorhabditis elegans Intestine. Int J Mol Sci. 2020 Nov 3;21(21):E8219. doi: 10.3390/ijms21218219. PMID: 33153048 
  • Gerisch B, Tharyan RG, Mak J, Denzel SI, Popkes-van Oepen T, Henn N, Antebi A (2020). HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence. Dev Cell. 2020 May 4;53(3):316-329.e5. doi: 10.1016/j.devcel.2020.03.014. Epub 2020 Apr 16. PMID: 32302543 
  • Tharyan RG, Annibal A, Schiffer I, Laboy R, Atanassov I, Weber AL, Gerisch B, Antebi A (2020). NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin. Nat Metab. 2020 May;2(5):387-396. doi: 10.1038/s42255-020-0200-2. Epub 2020 May 18. PMID: 32694663 
  • Kew C, Huang W, Fischer J, Ganesan R, Robinson N, Antebi A (2020). Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60. Elife. 2020 Jun 15;9:e57591. doi: 10.7554/eLife.57591 
  • Horn M, Denzel SI, Srinivasan B, Allmeroth K, Schiffer I, Karthikaisamy V, Miethe S, Breuer P, Antebi A, Denzel MS (2020). Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response. iScience. 2020 Mar 27; 23(3): 100887. Published online 2020 Feb 5. doi: 10.1016/j.isci.2020.100887 
  • Dabrowski R, Ripa R, Latza C, Annibal A, Antebi A (2020). Optimization of mass spectrometry settings for steroidomic analysis in young and old killifish. Anal Bioanal Chem. 2020 Jul;412(17):4089-4099. doi: 10.1007/s00216-020-02640-6. Epub 2020 Apr 24 
  • Chamoli M, Goyala A, Tabrez SS, Siddiqui AA, Singh A, Antebi A, Lithgow GJ, Watts JL, Mukhopadhyay A (2020). Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction. Nat Commun. 2020 Sep 25;11(1):4865. doi: 10.1038/s41467-020-18690-4

Miguel A. Alejandre Alcazar

  • Kuiper-Makris C, Zanetti D, Vohlen C, Fahle L, Müller M, Odenthal M, Felderhoff-Müser U, Dötsch J, Alejandre Alcazar MA (2020). Mendelian randomization and experimental IUGR reveal the adverse effect of low birth weight on lung structure and function. Sci Rep. 2020 Dec 28;10(1):22395. doi: 10.1038/s41598-020-79245-7. PMID: 33372189
  • Ubags N, Alejandre Alcazar MA, Kallapur SG, Knapp S, Lanone S, Lloyd CM, Morty RE, Pattaroni C, Reynaert NL, Rottier RJ,  Smits H, de Steenhuijsen Piters W, Strickland, DH, Collins JP. Early origins of lung disease: Towards an interdisciplinary approach. European Respiratory Journal. 2020 Oct 1;29(157):200191. doi: 10.1183/16000617.0191-2020
  • Wagner DE, Ubags ND, Troosters T, Alejandre Alcázar MA. Fostering the integration of basic respiratory science and translational pulmonary medicine for the future.  Am J Physiol Lung Cell Mol Physiol. 2020 Aug 5. doi: 10.1152/ajplung.00361.2020. Online ahead of print. 
  • Körner RW, Majjouti M, Alcazar MAA, Mahabir E (2020). Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2.   Viruses. 2020 Aug 12;12(8):E880. doi: 10.3390/v12080880.
  • Litzenburger T, Huber EK, Dinger K, Wilke R, Vohlen C, Kadah M, Persigehl T, Heneweer C, Doetsch J, Alejandre Alcazar MA( 2020).Maternal high-fat diet induces long-term obesity with sexdependent metabolic programming of adipocyte differentiation, hypertrophy and dysfunction in the offspring. Clinical Science. doi: 10.1042/CS20191229.
  • Mohr, J., Kesler, H., Hirani, D., Odenthal, M., Dötsch, J., and Alcazar, M.A.A. (2020). Loss of IL-6 promotes alveolar progenitor cells and lung growth in newborn mice exposed to mechanical ventilation. Eur Respir J56. 10.1183/13993003.congress-2020.5243.
  • Dinger K, v. Koningsbruggen-Rietschel S., Dötsch J, Alejandre Alcazar MA (2020). Identification of critical windows of metabolic programming of metabolism and lung function in male offspring of obese dams. Clinical and Translational Science. doi: 10.1111/cts.12811. Epub 2020
  • Fischer, J., Balleisen, J., Holzki, J., Cernaianu, G., Alcázar, M.A., and Dübbers, M. (2020). Tracheoscopic Findings and Their Impact on Respiratory Symptoms in Children with Esophageal Atresia. Eur J Pediatr Surg30, 371-377. 10.1055/s-0039-1683871.
  • Hirani, D., Koch, M., Mohr, J., Vohlen, C., Nayakanti, S., Grimm, C., Schweiger, M.R., Georgomanolis, T., Pullamsetti, S., Dötsch, J., and Alcazar, M.A.A. (2020). Novel KLF4-FOXO1 Interactome in Lung Fibroblasts:Regulator of Myofibroblasts in Hyperoxia-Induced Lung Injury. Eur Respir J56. 10.1183/13993003.congress-2020.5244.
  • Polanyi L, Niessen CM, Vohlen C, Stinn J, Kretschmer T, Jentgen V, Hirani D, Koningsbruggen-Rietschel SV, Dotsch J, Alejandre Alcazar MA. Intrauterine growth restriction induces skin inflammation, increases TSLP and impairs epidermal barrier function. J Mol Med (Berl) 2020. doi: 10.1007/s00109-019-01867-w.
  • Selle, J., Dinger, K., Kesler, H., Georgomanolis, T., Vohlen, C., Wilke, R., Dötsch, J., and Alcazar, M.A.A. (2020). Maternal and perinatal obesity arrests alveolarization and reduces alveolar progenitor cells in offspring. Eur Respir J56. 10.1183/13993003.congress-2020.5241.

Hisham Bazzi

  • Tamzalit F, Tran D, Jin W, Boyko V, Bazzi H, Kepecs A, Kam LC, Anderson KV, Huse M (2020). Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing. Proc Natl Acad Sci USA. 2020 Feb 25;117(8):431ß-4319. doi: 10.1073/pnas.1913220117

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Thomas Benzing

  • Schermer B, Fabretti F, Damagnez M, Di Cristanziano V, Heger E, Arjune S, Tanner NA, Imhof T, Koch M, Ladha A, Joung J, Gootenberg JS, Abudayyeh OO, Burst V, Zhang F, Klein F, Benzing T, Müller RU (2020). Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay. PLoS One. 2020 Nov 2;15(11):e0238612. doi: 10.1371/journal.pone.0238612. eCollection 2020. PMID: 33137122
  • Rarek MP, Meyer AM, Pickert L, Pilotto A, Benzing T, Burst V, Polidori MC (2020). The prognostic signature of health-related quality of life in older patients admitted to the emergency department: a 6-month follow-up study. Aging Clin Exp Res. 2020 Nov 1. doi: 10.1007/s40520-020-01732-8. Online ahead of print. PMID: 33135133 
  • Koehler S, Kuczkowski A, Kuehne L, Jüngst C, Hoehne M, Grahammer F, Eddy S, Kretzler M, Beck BB, Höhfeld J, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM (2020). Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis. J Am Soc Nephrol. 2020 Mar;31(3):544-559. doi: 10.1681/ASN.2019030312. Epub 2020 Feb 11. PMID: 32047005  
  • Binz-Lotter J, Jüngst C, Rinschen MM, Koehler S, Zentis P, Schauss A, Schermer B, Benzing T, Hackl MJ (2020). Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling. J Am Soc Nephrol. 2020 Mar;31(3):532-542. doi: 10.1681/ASN.2019020109. Epub 2020 Jan 10. PMID: 31924670 
  • Noetzel N, Meyer AM, Siri G, Pickert L, Heeß A, Verleysdonk J, Benzing T, Pilotto A, Barbe AG, Polidori MC (2020). The impact of oral health on prognosis of older multimorbid inpatients: the 6-month follow up MPI oral health study (MPIOH). Eur Geriatr Med. 2020 Nov 18. doi: 10.1007/s41999-020-00427-7. Online ahead of print. PMID: 33206351 
  • Bruno T, De Nicola F, Corleone G, Catena V, Goeman F, Pallocca M, Sorino C, Bossi G, Amadio B, Cigliana G, Ricciardi MR, Petrucci MT, Spugnini EP, Baldi A, Cioce M, Cortese G, Mattei E, Merola R, Gianelli U, Baldini L, Pisani F, Gumenyuk S, Mengarelli A, Höpker K, Benzing T, Vincenzi B, Floridi A, Passananti C, Blandino G, Iezzi S, Fanciulli M (2020). Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma. Blood Adv. 2020 Nov 24;4(22):5616-5630. doi: 10.1182/bloodadvances.2020002566. PMID: 33186461 
  • Unnersjö-Jess D, Butt L, Höhne M, Witasp A, Kühne L, Hoyer PF, Patrakka J, Brinkkötter PT, Wernerson A, Schermer B, Benzing T, Scott L, Brismar H, Blom H (2020). A Fast and Simple Clearing and Swelling Protocol for 3D In-Situ Imaging of the Kidney across Scales. Kidney Int. 2020 Dec 4:S0085-2538(20)31409-5. doi: 10.1016/j.kint.2020.10.039. Online ahead of print. PMID: 33285146 
  • Braun F, Rinschen M, Buchner D, Bohl K, Plagmann I, Bachurski D, Richard Späth M, Antczak P, Göbel H, Klein C, Lackmann JW, Kretz O, Puelles VG, Wahba R, Hallek M, Schermer B, Benzing T, Huber TB, Beyer A, Stippel D, Kurschat CE, Müller RU (2020). The proteomic landscape of small urinary extracellular vesicles during kidney transplantation. J Extracell Vesicles. 2020 Oct;10(1):e12026. doi: 10.1002/jev2.12026. Epub 2020 Nov 19. PMID: 33304478
  • Butt L, Unnersjö-Jess D, Höhne M, Edwards A, Binz-Lotter J, Reilly D, Hahnfeldt R, Ziegler V, Fremter K, Rinschen MM, Helmstädter M, Ebert LK, Castrop H, Hackl MJ, Walz G, Brinkkoetter PT, Liebau MC, Tory K, Hoyer PF, Beck BB, Brismar H, Blom H, Schermer B, Benzing T (2020). A molecular mechanism explaining albuminuria in kidney disease. Nat Metab. 2020 May;2(5):461-474. doi: 10.1038/s42255-020-0204-y. Epub 2020 May 11. PMID: 32694662 
  • Grundmann F, Müller RU, Hoyer-Allo KJR, Späth MR, Passmann E, Becker I, Pfister R, Baldus S, Benzing T, Burst V (2020). Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial. Sci Rep. 2020 Mar 23;10(1):5202. doi: 10.1038/s41598-020-61895-2. PMID: 32251303 
  • Benzing T (2020). Molecular Design of the Kidney Filtration Barrier. Trans Am Clin Climatol Assoc. 2020; 131: 125–139
  • Dafinger, C., Mandel, A.M., Braun, A., Gobel, H., Burgmaier, K., Massella, L., Mastrangelo, A., Dotsch, J., Benzing, T., Weimbs, T., Schermer, B., and Liebau, M.C. (2020). The carboxy-terminus of the human ARPKD protein fibrocystin can control STAT3 signalling by regulating SRC-activation. J Cell Mol Med24, 14633-14638. 10.1111/jcmm.16014.
  • Himmerkus, N., Svendsen, S.L., Quintanova, C., Bleich, M., Von Schwerdtner, O., Benzing, T., Welling, P.A., Leipziger, J., and Rinschen, M.M. (2020). Viewing Cortical Collecting Duct Function Through Phenotype-guided Single-Tubule Proteomics. Function (Oxf)1, zqaa007. 10.1093/function/zqaa007.
  • Johnsen, M., Kubacki, T., Yeroslaviz, A., Spath, M.R., Morsdorf, J., Gobel, H., Bohl, K., Ignarski, M., Meharg, C., Habermann, B., Altmuller, J., Beyer, A., Benzing, T., Schermer, B., Burst, V., and Muller, R.U. (2020). The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury. J Am Soc Nephrol31, 716-730. 10.1681/ASN.2019050534.
  • Matin, M., Morgelin, M., Stetefeld, J., Schermer, B., Brinkkoetter, P.T., Benzing, T., Koch, M., and Hagmann, H. (2020). Affinity-Enhanced Multimeric VEGF (Vascular Endothelial Growth Factor) and PlGF (Placental Growth Factor) Variants for Specific Adsorption of sFlt-1 to Restore Angiogenic Balance in Preeclampsia. Hypertension76, 1176-1184. 10.1161/HYPERTENSIONAHA.120.14974.
  • Meyer, A.M., Becker, I., Siri, G., Brinkkotter, P.T., Benzing, T., Pilotto, A., and Polidori, M.C. (2020). The prognostic significance of geriatric syndromes and resources. Aging Clin Exp Res32, 115-124. 10.1007/s40520-019-01168-9.

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Matteo Bergami

  • Gӧbel J, Engelhardt E, Pelzer P, Sakthivelu V, Jahn HM, Jevtic M, Folz-Donahue K, Kukat C, Schauss A, Frese CK, Giavalisco P, Ghanem A, Conzelmann KK, Motori E, Bergami M (2020). Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. Cell Metab. 2020 Apr 7; 31(4): 791–808.e8.doi: 10.1016/j.cmet.2020.03.005   
  • Ricke KM, Paß T, Kimoloi S, Fährmann K, Jüngst C, Schauss A, Baris OR, Aradjanski M, Trifunovic A, Eriksson Faelker TM, Bergami M, Wiesner RJ (2020). Mitochondrial dysfunction combined with high calcium load leads to impaired antioxidant defense underlying the selective loss of nigral dopaminergic neurons. J Neurosci. 2020 Jan 29. pii: 1345-19. doi: 10.1523/JNEUROSCI.1345-19.2019. [Epub ahead of print] 
  • Bergami M, Motori E (2020). Reweaving the Fabric of Mitochondrial Contact Sites in Astrocytes. Front Cell Dev Biol. 2020 Oct 23;8:592651. doi: 10.3389/fcell.2020.592651. eCollection 2020. PMID: 33195262

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Andreas Beyer

  • Charmpi K, Guo T, Zhong Q, Wagner U, Sun R, Toussaint NC, Fritz CE, Yuan C, Chen H, Rupp NJ, Christiansen A, Rutishauser D, Rüschoff JH, Fankhauser C, Saba K, Poyet C, Hermanns T, Oehl K, Moore AL, Beisel C, Calzone L, Martignetti L, Zhang Q, Zhu Y, Martínez MR, Manica M, Haffner MC, Aebersold R, Wild PJ, Beyer A (2020). Convergent network effects along the axis of gene expression during prostate cancer progression. Genome Biol. 2020 Dec 14;21(1):302. doi: 10.1186/s13059-020-02188-9. PMID: 33317623  
  • Braun F, Rinschen M, Buchner D, Bohl K, Plagmann I, Bachurski D, Richard Späth M, Antczak P, Göbel H, Klein C, Lackmann JW, Kretz O, Puelles VG, Wahba R, Hallek M, Schermer B, Benzing T, Huber TB, Beyer A, Stippel D, Kurschat CE, Müller RU (2020). The proteomic landscape of small urinary extracellular vesicles during kidney transplantation. J Extracell Vesicles. 2020 Oct;10(1):e12026. doi: 10.1002/jev2.12026. Epub 2020 Nov 19. PMID: 33304478
  • Kamrad S, Grossbach J, Rodríguez-López M, Mülleder M, Townsend S, Cappelletti V, Stojanovski G, Correia-Melo C, Picotti P, Beyer A, Ralser M, Bähler J (2020). Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance. Mol Syst Biol. 2020 Apr;16(4):e9270. doi: 10.15252/msb.20199270. PMID: 32319721  
  • Johnsen M, Kubacki T, Yeroslaviz A, Späth MR, Mörsdorf J, Göbel H, Bohl K, Ignarski M, Meharg C, Habermann B, Altmüller J, Beyer A, Benzing T, Schermer B, Burst V, Müller RU (2020). The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury. J Am Soc Nephrol. 31(4):716-730. doi: 10.1681/ASN.2019050534 
  • Benzing, T., Huber, T.B., Beyer, A., Stippel, D., Kurschat, C.E., and Müller, R.U. (2020). The proteomic landscape of small urinary extracellular vesicles during kidney transplantation. Journal of Extracellular Vesicles 10. ARTN e12026. 10.1002/jev2.12026.

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Susanne Brodesser

  • Schütter M, Giavalisco P, Brodesser S, Graef M (2020). Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy. Cell. 2020 Jan 9;180(1):135-149.e14. doi: 10.1016/j.cell.2019.12.005 . Epub 2019 Dec 26

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Jens Brüning  

  • Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA (2020). Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol. 2020 Jan;145(1):283-300.e8. doi: 10.1016/j.jaci.2019.07.033. Epub 2019 Aug 8  
  • Engström Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC (2020). NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons. Nat Commun. 2020 Jan 23;11(1):442. doi: 10.1038/s41467-020-14291-3  
  • Turpin-Nolan SM, Brüning JC (2020). The role of ceramides in metabolic disorders: when size and localization matters. Nat Rev Endocrinol. 2020 Feb 14. doi: 10.1038/s41574-020-0320-5. [Epub ahead of print] Review 
  • Mittenbühler MJ, Saedler K, Nolte H, Kern L, Zhou J, Qian SB, Meder L, Ullrich RT, Brüning JC, Wunderlich FT (2020). Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Mol Metab. 2020 Sep 18:101085. doi: 10.1016/j.molmet.2020.101085. Online ahead of print. PMID: 32956847 
  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532
  • DiToro D, Harbour SN, Bando JK, Benavides G, Witte S, Laufer VA, Moseley C, Singer JR, Frey B, Turner H, Brüning J, Darley-Usmar V, Gao M, Conover C, Hatton RD, Frank S, Colonna M, Weaver CT (2020). Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity. Immunity. 2020 Apr 14;52(4):650-667.e10. doi: 10.1016/j.immuni.2020.03.013. PMID: 32294406  
  • Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC (2020). MCH Neurons Regulate Permeability of the Median Eminence Barrier. Neuron. 2020 Jul 22;107(2):306-319.e9. doi: 10.1016/j.neuron.2020.04.020. Epub 2020 May 13. PMID: 32407670 
  • Lippert RN, Hess S, Klemm P, Burgeno LM, Jahans-Price T, Walton ME, Kloppenburg P, Brüning JC (2020). Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. J Clin Invest. 2020 Jul 1;130(7):3761-3776. doi: 10.1172/JCI134412. PMID: 32510473
  • Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC (2020). GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab. Jun 2;31(6):1189-1205.e13. doi: 10.1016/j.cmet.2020.05.001.
  • Fischer K, Fenzl A, Liu D, Dyar KA, Kleinert M, Brielmeier M, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Huang J, Keipert S, Klingenspor M, Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD (2020). The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nat Commun. May 8;11(1):2306. doi: 10.1038/s41467-020-16230-8.
  • Chowdhury S, Schulz L, Palmisano B, Singh P, Berger JM, Yadav VK, Mera P, Ellingsgaard H, Hidalgo J, Brüning J, Karsenty G (2020). Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts. J Clin Invest. Apr 27:133572. doi: 10.1172/JCI133572.
  • Koch, C.E., Begemann, K., Kiehn, J.T., Griewahn, L., Mauer, J., Hess, M.E., Moser, A., Schmid, S.M., Brüning, J.C., and Oster, H. (2020). Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA. Nat Commun11, 3071. 10.1038/s41467-020-16882-6.

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Oliver Cornely

  • Koehler P, Mellinghoff SC, Stemler J, Otte F, Berkhoff A, Beste N, Budin S, Cornely FB, Evans JM, Fuchs F, Pesch L, Rebholz AW, Reiner O, Schmitt M, Schuckelt J, Spiertz A, Salmanton-García J, Kron F, Cornely OA (2020). Quantifying guideline adherence in mucormycosis management using the EQUAL score. Mycoses. 2020 Apr;63(4):343-351. doi: 10.1111/myc.13047. Epub 2020 Jan 20. PMID: 31876327  
  • Aguilar RC, Salmanton-García J, Carney J, Böll B, Kochanek M, Jazmati N, Cornely OA, Vehreschild MJGT (2020). Clostridioides difficile infections in the intensive care unit: a monocentric cohort study. Infection. 2020 Jun;48(3):421-427. doi: 10.1007/s15010-020-01413-8. Epub 2020 Mar 24. PMID: 32212102
  • Steenwyk JL, Mead ME, de Castro PA, Valero C, Damasio A, Dos Santos RAC, Labella AL, Li Y, Knowles SL, Raja HA, Oberlies NH, Zhou X, Cornely OA, Fuchs F, Koehler P, Goldman GH, Rokas A (2020). Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus. bioRxiv. 2020 Nov 6:2020.11.06.371971. doi: 10.1101/2020.11.06.371971. Preprint. PMID: 33173866
  • Lanternier F, Seidel D, Pagano L, Styczynski J, Mikulska M, Pulcini C, Maertens J, Munoz P, Garcia-Vidal C, Rijnders B, Arendrup MC, Sabino R, Verissimo C, Gaustad P, Klimko N, Arikan-Akdagli S, Arsic V, Barac A, Skiada A, Klingspor L, Herbrecht R, Donnelly P, Cornely OA, Lass-Flörl C, Lortholary O (2020). Invasive pulmonary aspergillosis treatment duration in haematology patients in Europe: An EFISG, IDWP-EBMT, EORTC-IDG and SEIFEM survey. Mycoses. 2020 May;63(5):420-429. doi: 10.1111/myc.13056. Epub 2020 Mar 4. PMID: 32009262 
  • Jenks JD, Seidel D, Cornely OA, Chen S, van Hal S, Kauffman C, Miceli MH, Heinemann M, Christner M, Jover Sáenz A, Burchardt A, Kemmerling B, Herbrecht R, Steinmann J, Shoham S, Gräber S, Pagano L, Deeren D, Slavin MA, Hoenigl M (2020). Clinical characteristics and outcomes of invasive Lomentospora prolificans infections: Analysis of patients in the FungiScope® registry. Mycoses. 2020 May;63(5):437-442. doi: 10.1111/myc.13067. Epub 2020 Apr 15. PMID: 32080902  
  • Stemler J, Salmanton-García J, Seidel D, Alexander BD, Bertz H, Hoenigl M, Herbrecht R, Meintker L, Meißner A, Mellinghoff SC, Sal E, Zarrouk M, Koehler P, Cornely OA (2020). Risk factors and mortality in invasive Rasamsonia spp. infection: Analysis of cases in the FungiScope® registry and from the literature. Mycoses. 2020 Mar;63(3):265-274. doi: 10.1111/myc.13039. Epub 2019 Dec 10. PMID: 31769549 
  • Oladele RO, Akase IE, Fahal AH, Govender NP, Hoenigl M, Gangneux JP, Chiller TM, Denning DW, Cornely OA, Chakrabarti A (2020). Bridging the knowledge gap on mycoses in Africa: Setting up a Pan-African Mycology Working Group. Mycoses. 2020 Mar;63(3):244-249. doi: 10.1111/myc.13044. Epub 2019 Dec 30. PMID: 31829454 Review  
  • Bacher P, Rosati E, Esser D, Martini GR, Saggau C, Schiminsky E, Dargvainiene J, Schröder I, Wieters I, Khodamoradi Y, Eberhardt F, Vehreschild MJGT, Neb H, Sonntagbauer M, Conrad C, Tran F, Rosenstiel P, Markewitz R, Wandinger KP, Augustin M, Rybniker J, Kochanek M, Leypoldt F, Cornely OA, Koehler P, Franke A, Scheffold A (2020). Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19. Immunity. 2020 Nov 26:S1074-7613(20)30503-3. doi: 10.1016/j.immuni.2020.11.016. Online ahead of print. PMID: 33296686
  • Giesen N, Sprute R, Rüthrich M, Khodamoradi Y, Mellinghoff SC, Beutel G, Lueck C, Koldehoff M, Hentrich M, Sandherr M, von Bergwelt-Baildon M, Wolf HH, Hirsch HH, Wörmann B, Cornely OA, Köhler P, Schalk E, von Lilienfeld-Toal M (2020). Evidence-based management of COVID-19 in cancer patients: Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO). Eur J Cancer. 2020 Nov;140:86-104. doi: 10.1016/j.ejca.2020.09.009. Epub 2020 Sep 21. PMID: 33068941
  • Koehler P, Reimer R, Wahba R, Schömig-Markiefka B, Cornely OA (2020). Transdiaphragmatic Mucormycosis. Clin Infect Dis. 2020 Feb 14;70(5):940-942. doi: 10.1093/cid/ciz533. PMID: 31222210  
  • Schwartz S, Cornely OA, Hamed K, Marty FM, Maertens J, Rahav G, Herbrecht R, Heinz WJ (2020). Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system. Med Mycol. 2020 Jun 1;58(4):417-424. doi: 10.1093/mmy/myz103. PMID: 31613363  
  • Koehler P, Denis B, Denning DW, Gangneux JP, Hoenigl M, Kontoyiannis DP, Krause R, Lagrou K, Lass-Flörl C, Maertens J, Mareković I, Meis JF, Molina JM, Pleško S, Prattes J, Rath PM, Rautemaa-Richardson R, Richardson M, Segal E, Seidel D, Spriet I, Steinmann J, Verweij PE, Cornely OA; European Confederation of Medical Mycology (ECMM) (2020). European confederation of medical mycology expert consult-An ECMM excellence center initiative. Mycoses. 2020 Jun;63(6):566-572. doi: 10.1111/myc.13076. Epub 2020 Apr 13. PMID: 32181546 
  • Jenks JD, Seidel D, Cornely OA, Chen S, van Hal S, Kauffman C, Miceli MH, Heinemann M, Christner M, Jover Sáenz A, Burchardt A, Kemmerling B, Herbrecht R, Steinmann J, Shoham S, Gräber S, Pagano L, Deeren D, Aslam S, Taplitz R, Revankar SG, Baddley J, Mehta SR, Reed S, Slavin MA, Hoenigl M (2020). Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope® registry 2008-2019. Clin Microbiol Infect. 2020 Jun;26(6):784.e1-784.e5. doi: 10.1016/j.cmi.2020.01.012. Epub 2020 Jan 20. PMID: 31972317 
  • Verweij PE, Gangneux JP, Bassetti M, Brüggemann RJM, Cornely OA, Koehler P, Lass-Flörl C, van de Veerdonk FL, Chakrabarti A, Hoenigl M (2020). Diagnosing COVID-19-associated pulmonary aspergillosis. Lancet Microbe. 2020 Jun; 1(2): e53–e55. Published online 2020 May 10. doi: 10.1016/S2666-5247(20)30027-6 
  • Thompson Iii GR, Cornely OA, Pappas PG, Patterson TF, Hoenigl M, Jenks JD, Clancy CJ, Nguyen MH (2020). Invasive Aspergillosis as an Under-recognized Superinfection in COVID-19. Open Forum Infect Dis. 2020 Jun 19;7(7):ofaa242. doi:10.1093/ofid/ofaa242. eCollection 2020 Jul  
  • Stemler J, Koehler P, Maurer C, Müller C, Cornely OA (2020). Antifungal prophylaxis and novel drugs in acute myeloid leukemia: the midostaurin and posaconazole dilemma. Ann Hematol. 2020 Jul;99(7):1429-1440. doi: 10.1007/s00277-020-04107-1. Epub 2020 Jun 8 
  • Stemler J, Hamed K, Salmanton-García J, Rezaei-Matehkolaei A, Gräfe SK, Sal E, Zarrouk M, Seidel D, Abdelaziz Khedr R, Ben-Ami R, Ben-Chetrit E, Roth Y, Cornely OA (2020). Mucormycosis in the Middle East and North Africa: Analysis of the FungiScope® registry and cases from the literature. Mycoses. 2020 Oct;63(10):1060-1068. doi: 10.1111/myc.13123. Epub 2020 Aug 29 
  • Stemler J, Bruns C, Mellinghoff SC, Alakel N, Akan H, Ananda-Rajah M, Auberger J, Bojko P, Chandrasekar PH, Chayakulkeeree M, Cozzi JA, de Kort EA, Groll AH, Heath CH, Henze L, Hernandez Jimenez M, Kanj SS, Khanna N, Koldehoff M, Lee DG, Mager A, Marchesi F, Martino-Bufarull R, Nucci M, Oksi J, Pagano L, Phillips B, Prattes J, Pyrpasopoulou A, Rabitsch W, Schalk E, Schmidt-Hieber M, Sidharthan N, Soler-Palacín P, Stern A, Weinbergerová B, El Zakhem A, Cornely OA, Koehler P (2020). Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients. J Fungi (Basel). 2020 Mar; 6(1): 36. Published online 2020 Mar 13. doi: 10.3390/jof6010036 
  • Seidel D, Hassler A, Salmanton-García J, Koehler P, Mellinghoff SC, Carlesse F, Cheng MP, Falces-Romero I, Herbrecht R, Jover Sáenz A, Klimko N, Mareş M, Lass-Flörl C, Soler-Palacín P, Wisplinghoff H, Cornely OA, Pana Z, Lehrnbecher T (2020). Invasive Scedosporium spp. and Lomentospora prolificans infections in pediatric patients: Analysis of 55 cases from FungiScope® and the literature. Int J Infect Dis. 2020 Mar;92:114-122. doi: 10.1016/j.ijid.2019.12.017. Epub 2019 Dec 19
  • Schwartz S, Cornely OA, Hamed K, Marty FM, Maertens J, Rahav G, Herbrecht R, Heinz WJ (2020). Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system. Med Mycol. 2020 Jun 1;58(4):417-424. doi: 10.1093/mmy/myz103
  • Schommers P, Gruell H, Abernathy ME, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F (2020). Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell. 2020 Feb 6;180(3):471-489.e22. doi: 10.1016/j.cell.2020.01.010. Epub 2020 Jan 30
  • Salmanton-García J, Koehler P, Kindo A, Falces-Romero I, García-Rodríguez J, Ráčil Z, Chen SC, Klimko N, Desoubeaux G, Thompson Gr, III, Benítez-Peñuela M, Rodríguez JY, Sheppard DC, Hoenigl M, Le Govic Y, Badali H, Baddley JW, Chander J, Ingram PR, Pakstis DL, Mellinghoff SC, Atıcı S, Cesaro S, Chakrabarti A, Dupont D, González GM, Hatvani L, Herbrecht R, Klyasova G, Lass-Flörl C, Mareș M, Mullane K, Vinh DC, Wisplinghoff H, Lackner M, Cornely OA, Seidel D (2020). Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope(Ⓡ)-Global Registry for Emerging Fungal Infections. J Infect. 2020 Nov;81(5):802-815. doi: 10.1016/j.jinf.2020.08.015. Epub 2020 Aug 13
  • Laursen CB, Davidsen JR, Van Acker L, Salzer HJF, Seidel D, Cornely OA, Hoenigl M, Alastruey- Izquierdo A, Hennequin C, Godet C, Barac A, Flick H, Munteanu O, Van Braeckel E (2020). CPAnet Registry-An International Chronic Pulmonary Aspergillosis Registry. J Fungi (Basel). 2020 Jun 29;6(3):96. doi: 10.3390/jof6030096
  • Koehler P, Denis B, Denning DW, Gangneux JP, Hoenigl M, Kontoyiannis DP, Krause R, Lagrou K, Lass-Flörl C, Maertens J, Mareković I, Meis JF, Molina JM, Pleško S, Prattes J, Rath PM, Rautemaa-Richardson R, Richardson M, Segal E, Seidel D, Spriet I, Steinmann J, Verweij PE, Cornely OA (2020). European confederation of medical mycology expert consult-An ECMM excellence center initiative. Mycoses. 2020 Jun;63(6):566-572. doi: 10.1111/myc.13076. Epub 2020 Apr 13
  • Koehler P, Cornely OA, Böttiger BW, Dusse F, Eichenauer DA, Fuchs F, Hallek M, Jung N, Klein F, Persigehl T, Rybniker J, Kochanek M, Böll B, Shimabukuro-Vornhagen A (2020). COVID-19 associated pulmonary aspergillosis. Mycoses. 2020 Jun;63(6):528-534. doi: 10.1111/myc.13096. Epub 2020 May 15
  • Jakob CEM, Stecher M, Classen AY, Hamprecht A, Cornely OA, Vehreschild JJ (2020). Association Between Prescribed Opioids and Infections in Patients Neutropenia and Cancer. JAMA Intern Med. 2019 Nov 4. doi: 10.1001/jamainternmed.2019.4714. [Epub ahead of print]
  • Hanssen R, Kohlenbach L, Albus K, Edwin Thanarajah S, Cornely OA, Tittgemeyer M, Faust M (2020). Erfolgreiche Lebensstiländerung für schwer adipöse Patienten - Eine kontrollierte Studie zur Evaluation eines Patientenschulungsprogramms. Diabetologie und Stoffwechsel 2020; 15(02): 157-64
  • Guery B, Georgopali A, Karas A, Kazeem G, Michon I, Wilcox MH, Cornely OA (2020). Pharmacokinetic analysis of an extended-pulsed fidaxomicin regimen for the treatment of Clostridioides (Clostridium) difficile infection in patients aged 60 years and older in the EXTEND randomized controlled trial. J Antimicrob Chemother. 2020 Apr 1;75(4):1014-1018. doi: 10.1093/jac/dkz549
  • Fürstenau M, Simon F, Cornely OA, Hicketier T, Eichhorst B, Hallek M, Mellinghoff SC (2020). Invasive Aspergillosis in Patients Treated With Ibrutinib. Hemasphere. 2020 Apr; 4(2): e309. Published online 2020 Feb 13. doi: 10.1097/HS9.0000000000000309
  • Davies K, Lawrence J, Berry C, Davis G, Yu H, Cai B, Gonzalez E, Prantner I, Kurcz A, Macovei I, Pituch H, Nováková E, Nyč O, Gärtner B, Berger FK, Oleastro M, Cornely OA, Vehreschild M, Pedneault L, Wilcox M (2020). Risk Factors for Primary Clostridium difficile Infection; Results From the Observational Study of Risk Factors for Clostridium difficile Infection in Hospitalized Patients With Infective Diarrhea (ORCHID). Front Public Health. 2020 Jul 17;8:293. doi: 10.3389/fpubh.2020.00293. eCollection 2020
  • Cornely OA, Mullane KM, Birch T, Hazan-Steinberg S, Nathan R, Bouza E, Calfee DP, Ellison MC, Wong MT, Dorr MB (2020). Exploratory Evaluation of Bezlotoxumab on Outcomes Associated With Clostridioides difficile Infection in MODIFY I/II Participants With Cancer. Open Forum Infect Dis. 2020 Feb; 7(2): ofaa038. Published online 2020 Jan 31. doi: 10.1093/ofid/ofaa038
  • Cornely OA, Cisneros JM, Torre-Cisneros J, Rodríguez-Hernández MJ, Tallón-Aguilar L, Calbo E, Horcajada JP, Queckenberg C, Zettelmeyer U, Arenz D, Rosso-Fernández CM, Jiménez-Jorge S, Turner G, Raber S, O'Brien S, Luckey A (2020). Pharmacokinetics and safety of aztreonam/avibactam for the treatment of complicated intra-abdominal infections in hospitalized adults: results from the REJUVENATE study. J Antimicrob Chemother. 2020 Mar 1;75(3):618-627. doi: 10.1093/jac/dkz497
  • Cornely FB, Cornely OA, Salmanton-García J, Koehler FC, Koehler P, Seifert H, Wingen-Heimann S, Mellinghoff SC (2020). Attributable mortality of candidemia after introduction of echinocandins. Mycoses. 2020 Dec;63(12):1373-1381. doi: 10.1111/myc.13177. Epub 2020 Sep 27
  • Bouza E, Cornely OA, Ramos-Martinez A, Plesniak R, Ellison MC, Hanson ME, Dorr MB (2020). Analysis of C. difficile infection-related outcomes in European participants in the bezlotoxumab MODIFY I and II trials. Eur J Clin Microbiol Infect Dis. 2020 Oct;39(10):1933-1939. doi: 10.1007/s10096-020-03935-3. Epub 2020 Jun 6
  • Augustin M, Schommers P, Suárez I, Koehler P, Gruell H, Klein F, Maurer C, Langerbeins P, Priesner V, Schmidt-Hellerau K, Malin JJ, Stecher M, Jung N, Wiesmüller G, Meissner A, Zweigner J, Langebartels G, Kolibay F, Suárez V, Burst V, Valentin P, Schedler D, Cornely OA, Hallek M, Fätkenheuer G, Rybniker J, Lehmann C (2020). Rapid response infrastructure for pandemic preparedness in a tertiary care hospital: lessons learned from the COVID-19 outbreak in Cologne, Germany, February to March 2020. Euro Surveill. 2020 May 28; 25(21): 2000531. doi: 10.2807/1560-7917.ES.2020.25.21.2000531
  • Arastehfar A, Carvalho A, van de Veerdonk FL, Jenks JD, Koehler P, Krause R, Cornely OA, D SP, Lass-Flörl C, Hoenigl M (2020). COVID-19 Associated Pulmonary Aspergillosis (CAPA)-From Immunology to Treatment. J Fungi (Basel). 2020 Jun; 6(2): 91.Published online 2020 Jun 24. doi: 10.3390/jof6020091
  • Koehler P, Adam M, Cornely OA (2020). Aspergillus endocarditis. MSG ERC Doctor Fungus, 2020 Feb 2020
  • Johnson MD, Lewis RE, Dodds Ashley ES, Ostrosky-Zeichner L, Zaoutis T, Thompson GR, Andes DR, Walsh TJ, Pappas PG, Cornely OA, Perfect JR, Kontoyiannis DP (2020). Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium. J Infect Dis. 2020 Aug 5;222(Supplement_3):S175-S198. doi: 10.1093/infdis/jiaa394
  • Jenks JD, Cornely OA, Chen SC, Thompson GR, 3rd, Hoenigl M (2020). Breakthrough invasive fungal infections: Who is at risk? Mycoses. 2020 Oct;63(10):1021-1032. doi: 10.1111/myc.13148. Epub 2020 Sep 4
  • Chakrabarti A, Meis JF, Cornely OA (2020). International Society for Human and Animal Mycology (ISHAM)-New Initiatives. J Fungi (Basel). 2020 Jun 30;6(3):97. doi: 10.3390/jof6030097
  • von Lilienfeld-Toal M, Vehreschild JJ, Cornely O, Pagano L, Compagno F, Hirsch HH (2020). Frequently asked questions regarding SARS-CoV-2 in cancer patients-recommendations for clinicians caring for patients with malignant diseases. Leukemia. 2020 Jun;34(6):1487-1494. doi: 10.1038/s41375-020-0832-y. Epub 2020 May 1.
  • Ruhnke M, Cornely OA, Schmidt-Hieber M, Alakel N, Boell B, Buchheidt D, Christopeit M, Hasenkamp J, Heinz WJ, Hentrich M, Karthaus M, Koldehoff M, Maschmeyer G, Panse J, Penack O, Schleicher J, Teschner D, Ullmann AJ, Vehreschild M, von Lilienfeld-Toal M, Weissinger F, Schwartz S (2020). Treatment of invasive fungal diseases in cancer patients-Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Mycoses. 2020 Jul;63(7):653-682. doi: 10.1111/myc.13082. Epub 2020 May 12
  • Schommers, P., Gruell, H., Abernathy, M.E., Tran, M.K., Dingens, A.S., Gristick, H.B., Barnes, C.O., Schoofs, T., Schlotz, M., Vanshylla, K., Kreer, C., Weiland, D., Holtick, U., Scheid, C., Valter, M.M., van Gils, M.J., Sanders, R.W., Vehreschild, J.J., Cornely, O.A., Lehmann, C., Fatkenheuer, G., Seaman, M.S., Bloom, J.D., Bjorkman, P.J., and Klein, F. (2020). Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell180, 471-489 e422. 10.1016/j.cell.2020.01.010.
  • Stemler, J., Bruns, C., Mellinghoff, S.C., Alakel, N., Akan, H., Ananda-Rajah, M., Auberger, J., Bojko, P., Chandrasekar, P.H., Chayakulkeeree, M., Cozzi, J.A., de Kort, E.A., Groll, A.H., Heath, C.H., Henze, L., Hernandez Jimenez, M., Kanj, S.S., Khanna, N., Koldehoff, M., Lee, D.G., Mager, A., Marchesi, F., Martino-Bufarull, R., Nucci, M., Oksi, J., Pagano, L., Phillips, B., Prattes, J., Pyrpasopoulou, A., Rabitsch, W., Schalk, E., Schmidt-Hieber, M., Sidharthan, N., Soler-Palacin, P., Stern, A., Weinbergerova, B., El Zakhem, A., Cornely, O.A., and Koehler, P. (2020). Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients. J Fungi (Basel)6. 10.3390/jof6010036.
  • Verweij, P.E., Rijnders, B.J.A., Bruggemann, R.J.M., Azoulay, E., Bassetti, M., Blot, S., Calandra, T., Clancy, C.J., Cornely, O.A., Chiller, T., Depuydt, P., Giacobbe, D.R., Janssen, N.A.F., Kullberg, B.J., Lagrou, K., Lass-Florl, C., Lewis, R.E., Liu, P.W., Lortholary, O., Maertens, J., Martin-Loeches, I., Nguyen, M.H., Patterson, T.F., Rogers, T.R., Schouten, J.A., Spriet, I., Vanderbeke, L., Wauters, J., and van de Veerdonk, F.L. (2020). Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion. Intensive Care Med46, 1524-1535. 10.1007/s00134-020-06091-6.

Joris Deelen

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  • Deelen J (2020). Searching for the genetic key to a long and healthy life. Elife. 2020 Apr 24;9:e57242. doi: 10.7554/eLife.57242 
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  • Li C, Stoma S, Lotta LA, Warner S, Albrecht E, Allione A, Arp PP, Broer L, Buxton JL, Da Salva Couto Alves A, Deelen J, Fedko IO, Gordon SD, Jiang T, Karlsson R, Kerrison N, Loe TK, Mangino M, Milaneschi Y, Miraglio B, Perviakova N, Russo A, Surakka I, van der Spek A, Verhoeven IE, Amin N, Beekman M, Blakemore AI, Canzian F, Hamby SE, Hottenga JJ, Jones PD, Jousilahti P, Mägi R, Medland SE, Montgomery GW, Nyholt DR, Perola M, Pietiläinen KH, Salomaa V, Sillanpää E, Suchiman HE, van Heemst D, Willemsen G, Agudo A, Boeing H, Boomsma DI, CHirlaque MD, Fagherazzi G, Ferrari P, Franks P, Gieger C, Eriksson JG, Gunter M, Hägg S, Hovatta J, Imaz L, Kaprio J, Kaaks R, Key T, Krogh V, Martin NG, Melander O, Metspalu A, Moreno C, Onland-Moret NC, Nilsson P, Ong KK, Overvad K, Palli D, Panico S, Pedersen NL, Penninx BWJH, Quiros JR, Jarvelin MR, Rodriguez-Barranco M, Scott RA, Severi G, Slagboom PE, Spector TD, Tionneland A, Trichopoulou A, Tumino R, Uitterlinden AG, van der Schouw YT, van Dujin CM, Weiderpass E, Denchi EL, Matullo G, Butterworth AS, Danesh J, Samani NJ, Wareham NJ, Nelson CP, Langenberg C, Codd V (2020). Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet. 2020 Mar 5;106(3):389-404.  doi: 10.1016/j.ajhg.2020.02.006. Epub 2020 Feb 27 
  • Van den Akker EB, Trompet S, Wolf JJHB, Beekman M, Suchiman HED, Deelen J, Asselbergs FW, Boersma E, Cats D, Elders PM, Gelejnse JM, Ikram MA, Kloppenburg M, Mei H, Meulenbelt I, Mooijaart SP, Nelissen RGHH, Netea MG, Penninx BWJH, Slofstra M, Stehouwer CDA, Swertz MA, Teunissen CE, Terwindt GM, Hart LM, van den Maagdenberg AMJM, van der Harst P, van der Horst ICC, van der Kallen CJH, van Greevenbroek MMJ, van Spil WE, Wijmenga C, Zhernakova A, Zwinderman AH, Sattar N, Jukema JW, van Dujin CM, Boomsma DI, Reinders MJT, Slagboom E (2020). Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circ Genom Precis Med. 2020 Oct;13(5):541-547.  doi: 10.1161/CIRCGEN.119.002610. Epub 2020 Aug 14
  • Hagenbeek, F.A., Pool, R., van Dongen, J., Draisma, H.H.M., Hottenga, J.J., Willemsen, G., Abdellaoui, A., Fedko, I.O., den Braber, A., Visser, P.J., de Geus, E.J.C.N., van Dijk, K.W., Verhoeven, A., Suchiman, H.E., Beekman, M., Slagboom, P.E., van Duijn, C.M., Harms, A.C., Hankemeier, T., Bartels, M., Nivard, M.G., Boomsma, D.I., Wolf, J.J.H.B., Cats, D., Amin, N., Beulens, J.W., van der Bom, J.A., Bomer, N., Demirkan, A., van Hilten, J.A., Meessen, J.M.T.A., Moed, M.H., Fu, J., Onderwater, G.L.J., Rutters, F., So-Osman, C., van der Flier, W.M., van der Heijden, A.A.W.A., van der Spek, A., Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Teunissen, C.E., Terwindt, G.M., 't Hart, L.M., van den Maagdenberg, A.M.J.M., van der Harst, P., van der Horst, I.C.C., van der Kallen, C.J.H., van Greevenbroek, M.M.J., van Spil, W.E., Wijmenga, C., Zwinderman, A.H., Zhernikova, A., Jukema, J.W., Mei, H., Slofstra, M., Swertz, M., van den Akker, E.B., Deelen, J., Reinders, M.J.T., and Consortium, B.M. (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nat Commun11. ARTN 39. 10.1038/s41467-019-13770-6.
  • Pool, R., Hagenbeek, F.A., Hendriks, A.M., van Dongen, J., Willemsen, G., de Geus, E., van Dijk, K.W., Verhoeven, A., Suchiman, H.E., Beekman, M., Slagboom, P.E., Harms, A.C., Hankemeier, T., Boomsma, D.I., Beekman, M., Suchiman, H.E.D., Amin, N., Beulens, J.W., van der Bom, J.A., Bomer, N., Demirkan, A., van Hilten, J.A., Meessen, J.M.T.A., Pool, R., Moed, M.H., Fu, J., Onderwater, G.L.J., Rutters, F., So-Osman, C., van der Flier, W.M., van der Heijden, A.A.W.A., van der Spek, A., Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Teunissen, C.E., Terwindt, G.M., 't Hart, L.M., van den Maagdenberg, A.M.J.M., van der Harst, P., van der Horst, I.C.C., van der Kallen, C.J.H., van Greevenbroek, M.M.J., van Spil, W.E., Wijmenga, C., Zwinderman, A.H., Zhernikova, A., Jukema, J.W., Wolf, J.J.H.B., Cats, D., Mei, H., Slofstra, M., Swertz, M., van den Akker, E.B., Deelen, J., Reinders, M.J.T., Boomsma, D.I., van Duijn, C.M., Slagboom, P.E., and Consortium, B.M. (2020). Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data. Twin Res Hum Genet23, 145-155. PII S1832427420000535. 10.1017/thg.2020.53.
  • Timmers, P., Wilson, J., Joshi, P., and Deelen, J. (2020). Multivariate Genomic Scan of Human Ageing Traits Reveals Novel Loci and Identifies Haem Metabolism as a Human Ageing Pathway. Hum Hered84, 226-226.

Martin Denzel

  • Horn M, Denzel SI, Srinivasan B, Allmeroth K, Schiffer I, Karthikaisamy V, Miethe S, Breuer P, Antebi A, Denzel MS (2020). Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response. iScience. 2020 Mar 27; 23(3): 100887. Published online 2020 Feb 5. doi: 10.1016/j.isci.2020.100887 
  • Ruegenberg S, Horn M, Pichlo C, Allmeroth K, Baumann U, Denzel MS (2020). Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun. 2020 Feb 4;11(1):687. doi: 10.1038/s41467-020-14524-5 
  • Allmeroth K, Horn M, Kroef V, Miethe S, Müller RU, Denzel MS (2020). Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma. Leukemia. doi.org/10.1038/s41375-020-0989-4 
  • Kim CS, Ding X, Allmeroth K, Biggs LC, Kolenc OI, L’Hoest N, Chacón-Martínez CA, Edlich-Muth C, Giavalisco P,Quinn KP, Denzel MS, Eming SA, Wickström SA (2020). Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. Cell Metab. 2020 Oct 6;32(4):629-642.e8.  doi: 10.1016/j.cmet.2020.08.011. Epub 2020 Sep 8  
  • Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG (2020). Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716.  doi: 10.1038/s41586-020-03048-z. Epub 2020 Dec 16
  • Saez, I., Gerbracht, J.V., Koyuncu, S., Lee, H.J., Horn, M., Kroef, V., Denzel, M.S., Dieterich, C., Gehring, N.H., and Vilchez, D. (2020). The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. Febs Lett594, 175-188. 10.1002/1873-3468.13559.

Alexander Dilthey

  • Walker A, Houwaart T, Wienemann T, Vasconcelos MK, Strelow D, Senff T, Hulse L, Adams O, Andree M, Hauka S, Feldt T, Jensen BE, Keitel V, Kindgen-Milles D, Timm J, Pfeffer K, Dilthey AT (2020). Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020. Euro Surveill. 2020 Jun 4; 25(22): 2000746
  • Dilthey AT, Meyer SA, Kaasch AJ (2020). Ultraplexing: increasing the efficiency of long-read sequencing for hybrid assembly with k-mer-based multiplexing. Genome Biol. 2020; 21: 68
  • Henrich B, Hammerlage S, Scharf S, Haberhausen D, Fürnkranz U, Köhrer K, Peitzmann L, Fiori PL, Spergser J, Pfeffer K, Dilthey AT (2020). Characterisation of mobile genetic elements in Mycoplasma hominis with the description of ICEHo-II, a variant mycoplasma integrative and conjugative element. Mob DNA. 2020 Nov 7;11(1):30. doi: 10.1186/s13100-020-00225-9. PMID: 33292499
  • Chin CS, Wagner J, Zeng Q, Garrison E, Garg S, Fungtammasan A, Rautiainen M, Aganezov S, Kirsche M, Zarate S, Schatz MC, Xiao C, Rowell WJ, Markello C, Farek J, Sedlazeck FJ, Bansal V, Yoo B, Miller N, Zhou X, Carroll A, Barrio AM, Salit M, Marschall T, Dilthey AT, Zook JM (2020). A diploid assembly-based benchmark for variants in the major histocompatibility complex. Nat Commun. 2020 Sep 22;11(1):4794. doi: 10.1038/s41467-020-18564-9. PMID: 32963235; PMCID: PMC7508831.
  • Ramani A, Müller L, Ostermann PN, Gabriel E, Abida-Islam P, Müller-Schiffmann A, Mariappan A, Goureau O, Gruell H, Walker A, Andrée M, Hauka S, Houwaart T, Dilthey AT, Wohlgemuth K, Omran H, Klein F, Wieczorek D, Adams O, Timm J, Korth C, Schaal H, Gopalakrishnan J (2020). SARS-CoV-2 targets neurons of 3D human brain organoids. EMBO J.2020 Oct 15;39(20):e106230. doi: 10.15252/embj.2020106230. Epub 2020 Sep 23. PMID: 32876341; PMCID: PMC7560208.
  • Gleadall NS, Veldhuisen B, Gollub J, Butterworth AS, Ord J, Penkett CJ, Timmer TC, Sauer CM, van der Bolt N, Brown C, Brugger K, Dilthey AT, Duarte D, Grimsley S, van den Hurk K, Jongerius JM, Luken J, Megy K, Miflin G, Nelson CS, Prinsze FJ, Sambrook J, Simeoni I, Sweeting M, Thornton N, Trompeter S, Tuna S, Varma R, Walker MR; NIHR BioResource, Danesh J, Roberts DJ, Ouwehand WH, Stirrups KE, Rendon A, Westhoff CM, Di Angelantonio E, van der Schoot CE, Astle WJ, Watkins NA, Lane WJ. Development and validation of a universal blood donor genotyping platform: a multinational prospective study. Blood Adv. 2020 Aug 11;4(15):3495-3506. doi: 10.1182/bloodadvances.2020001894. PMID: 32750130; PMCID: PMC7422129.
  • Sallah N, Miley W, Labo N, Carstensen T, Fatumo S, Gurdasani D, Pollard MO, Dilthey AT, Mentzer AJ, Marshall V, Cornejo Castro EM, Pomilla C, Young EH, Asiki G, Hibberd ML, Sandhu M, Kellam P, Newton R, Whitby D, Barroso I. Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections. Nat Commun.2020 Jul 31;11(1):3849. doi: 10.1038/s41467-020-17696-2. PMID: 32737300; PMCID: PMC7395761.

Sabine Eming

  • Kakanj P, Eming SA, Partridge L, Leptin M (2020). Long-term in vivo imaging of Drosophila larvae. Nat Protoc. 2020 Feb 10. doi: 10.1038/s41596-019-0282-z. [Epub ahead of print] 
  • Kim CS#, Ding X#, Allmeroth K, Biggs LC, Kolenc OI, L’HoestN, Chacón-MartínezCA, Edlich-MuthC, GiavaliscoP, QuinnKP, Denzel, EmingSA* and Wickström SA*. (2020). Glutamine metabolism controls stem cell fate reversibility and long-term maintenance in the hair follicle. Cell Metab. 32:629-642.e8 doi: 10.1016/j.cmet.2020.08.011. Epub 2020 Sep 8. PMID: 32905798. # shared first authorship; * corresponding authors 
  • Ding X, Willenborg, S, Bloch W, Wickström S, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg M, Eming SA (2020). Epidermal mTORC2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol. 2020 Jan;145(1):283-300.e8. doi: 10.1016/j.jaci.2019.07.033  
  • Schiffmann LM, Werthenbach JP, Heintges-Kleinhofer F, Seeger JM, Fritsch M, Günther SD, Willenborg S, Brodesser S, Lucas C, Jüngst C,Albert MC, SchornF, Witt A, Moraes CT, Bruns CJ, Pasparakis M, Krönke M, Eming SA, Coutelle O, Kashkar H (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumor growth. Nat Commun. 2020 Jul 21;11(1):3653. doi: 10.1038/s41467-020-17472-2  
  • Schönborn K, Willenborg S, Schulz JN, Imhof T, Eming SA, Quondamatteo F, Brinckmann J, Niehoff A, Paulsson M, Koch M, Eckes B, Krieg T (2020). Role of collagen XII in skin homeostasis and repair. Matrix Biol. 94:57-76. doi: 10.1016/j.matbio.2020.08.002  
  • Rongisch R, Koll P, Eming SA (2020). Targeted therapies in Pyoderma gangrenosum: deciphering pathophysiology and improving disease management. Hautarzt. 71:880-886. doi: 10.1007/s00105-020-04697-x  
  • Peltonen S, Eming SA, Griffiths CEM, Széll M, Kelsell D, De Rie MA (2020). Celebrating the 50th Anniversary of ESDR. J Invest Dermatol. 140(9S):S145-S146. doi: 10.1016/j.jid.2020.02.043. * corresponding authors
  • Satzinger, S., Voehringer, D., Roers, A., and Eming, S.A. (2020). The Role of Type 2 Immunity in Skin Regenerative Responses. Wound Repair Regen 28, A13-A13.

Mafalda Escobar-Henriques 

  • Joaquim M, Escobar-Henriques M (2020). Role of Mitofusins and  Mitophagy in Life or Death Decisions. Front Cell Dev Biol. 2020 Sep 22;8:572182. doi: 10.3389/fcell.2020.572182. eCollection 2020. PMID: 33072754 Review
  • Schuster R, Anton V, SimoesT, Altin S, den Brave F, Hermanns T, Hospenthal M, Komander D, Dittmar G, Dohmen RJ, Escobar-Henriques M (2020). Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation. Life Sci Alliance. 2020 Jan; 3(1): e201900476. Published online 2019 Dec 19 
  • Escobar-Henriques M, Anton V (2020). Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion. Int J Mol Sci. 2020 Sep 18;21(18):E6841. doi: 10.3390/ijms21186841. PMID: 32961852 Review.
  • Escobar-Henriques, M., Altin, S., and den Brave, F. (2020). Interplay between the Ubiquitin Proteasome System and Mitochondria for Protein Homeostasis. Curr Issues Mol Biol35, 35-58. 10.21775/cimb.035.035.

Lukas P. Frenzel

  • Althoff, K., Leitzke, S., Herling, C., Frenzel, L., Herling, M., Holtick, U., Scheid, C., von Bergwelt-Baildon, M., and Theurich, S. (2020). Metabolic Status and Immune Activation Influence Clinical Outcomes in Patients after Allogeneic Hematopoietic Stem Cell Transplantation. Journal for Immunotherapy of Cancer8, A17-A17. 10.1136/jitc-2020-ITOC7.31.
  • Holtick, U., Herling, M., Frenzel, L.P., Herling, C., Schiller, J., Aguilar, M.R.C., Theurich, S., Hallek, M., and Scheid, C. (2020). A Phase II Study to Investigate the Efficacy of shortterm Everolimus in Addition to post-transplant Cyclophosphamide as graft-versus-host-prophylaxis after Allogeneic Stem Cell Transplantation (Octet-ever). Bone Marrow Transpl55, 290-291.
  • Riabinska, A., Lehrman, D., Jachimowicz, R.D., Knitter, G., Fritz, C., Schmitt, A., Geyer, A., Heneweer, C., Wittersheim, M., Frenzel, L.P., Torgovnick, A., Wiederstein, J.L., Wunderlich, C.M., Ortmann, M., Paillard, A., Wössmann, W., Borkhardt, A., Burdach, S., Hansmann, M.L., Rosenwald, A., Perner, S., Mall, G., Klapper, W., Merseburg, A., Krüger, M., Grüll, H., Persigehl, T., Wunderlich, F.T., Peifer, M., Utermöhlen, O., Büttner, R., Beleggia, F., and Reinhardt, H.C. (2020). ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia34, 771-786. 10.1038/s41375-019-0618-2.
  • Rieger, C., and Frenzel, L. (2020). Certified and scientifically appraised Online Advanced Training AbbVie CME Academy: Time and spatially flexible Advanced Training in the Hemato-oncology. Oncol Res Treat43, 637-637.

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Christan Frezza

  • Ko JH, Olona A, Papathanassiu AE, Buang N, Park KS, Costa ASH, Mauro C, Frezza C, Behmoaras J (2020). BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages. J Cell Sci. 2020 Nov 27;133(22):jcs247957. doi: 10.1242/jcs.247957. PMID: 33148611; PMCID: PMC7116427. 
  • Fendt SM, Frezza C, Erez A (2020). Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy. Cancer Discov. 2020 Dec;10(12):1797-1807. doi: 10.1158/2159-8290.CD-20-0844. Epub 2020 Nov 2. PMID: 33139243; PMCID: PMC7710573. 
  • Forte D, García-Fernández M, Sánchez-Aguilera A, Stavropoulou V, Fielding C, Martín-Pérez D, López JA, Costa ASH, Tronci L, Nikitopoulou E, Barber M, Gallipoli P, Marando L, Fernández de Castillejo CL, Tzankov A, Dietmann S, Cavo M, Catani L, Curti A, Vázquez J, Frezza C, Huntly BJ, Schwaller J, Méndez-Ferrer S (2020). Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metab. 2020 Nov 3;32(5):829-843.e9. doi: 10.1016/j.cmet.2020.09.001. Epub 2020 Sep 22. PMID: 32966766; PMCID: PMC7658808. 
  • O' Neill JS, Hoyle NP, Robertson JB, Edgar RS, Beale AD, Peak-Chew SY, Day J, Costa ASH, Frezza C, Causton HC (2020). Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis. Nat Commun. 2020 Sep 17;11(1):4706. doi: 10.1038/s41467-020-18330-x. PMID: 32943618; PMCID: PMC7499178. 
  • Bailey PSJ, Ortmann BM, Martinelli AW, Houghton JW, Costa ASH, Burr SP, Antrobus R, Frezza C, Nathan JA (2020). ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex. Nat Commun. 2020 Aug 13;11(1):4046. doi: 10.1038/s41467-020-17862-6. PMID: 32792488; PMCID: PMC7426941. 
  • Xu R, Jones W, Wilcz-Villega E, Costa AS, Rajeeve V, Bentham RB, Bryson K, Nagano A, Yaman B, Olendo Barasa S, Wang Y, Chelala C, Cutillas P, Szabadkai G, Frezza C, Bianchi K (2020). The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism. EMBO Rep. 2020 Sep 3;21(9):e48260. doi: 10.15252/embr.201948260. Epub 2020 Aug 11. PMID: 32783398; PMCID: PMC7116048. 
  • Frezza C (2020). A BAD portion of glucose can be good for inflamed beta cells. Nat Metab. 2020 May;2(5):383-384. doi: 10.1038/s42255-020-0198-5. Erratum in: Nat Metab. 2020 Jul;2(7):649. PMID: 32694661. 
  • Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker AM, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Balkwill FR, Sosabowski J, Cutillas PR, Frezza C, Sancho P, Hodivala-Dilke K (2020). Cancer associated fibroblast FAK regulates malignant cell metabolism. Nat Commun. 2020 Mar 10;11(1):1290. doi: 10.1038/s41467-020-15104-3. PMID: 32157087; PMCID: PMC7064590. 
  • Schmidt C, Sciacovelli M, Frezza C (2020). Fumarate hydratase in cancer: A multifaceted tumour suppressor. Semin Cell Dev Biol. 2020 Feb;98:15-25. doi: 10.1016/j.semcdb.2019.05.002. Epub 2019 May 22. PMID: 31085323; PMCID: PMC6974395. 
  • Frezza C (2020). Metabolism and cancer: the future is now. Br J Cancer. 2020 Jan;122(2):133-135. doi: 10.1038/s41416-019-0667-3. Epub 2019 Dec 10. PMID: 31819199; PMCID: PMC6978144. 
  • Lord SR, Collins JM, Cheng WC, Haider S, Wigfield S, Gaude E, Fielding BA, Pinnick KE, Harjes U, Segaran A, Jha P, Hoefler G, Pollak MN, Thompson AM, Roy PG, English R, Adams RF, Frezza C, Buffa FM, Karpe F, Harris AL (2020). Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin. Br J Cancer. 2020 Jan;122(2):258-265. doi: 10.1038/s41416-019-0665-5. Epub 2019 Dec 10. PMID: 31819193; PMCID: PMC6986920.

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Henning Fenselau

  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532 
  • Reinoß P, Ciglieri E, Minére M, Bremser S, Klein A, Löhr H, Fuller PM, Büschges A, Kloppenburg P, Fenselau H, Hammerschmidt M (2020). Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits.  Curr Biol. 2020 Dec 7;30(23):4579-4593.e7. doi: 10.1016/j.cub.2020.08.103. Epub 2020 Sep 24. PMID: 32976803 
  • Engström Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC (2020). NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.  Nat Commun. 2020 Jan 23;11(1):442. doi: 10.1038/s41467-020-14291-3. PMID: 31974377

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Ana J. Garcia-Saez

  • Peña-Blanco A, Haschka MD, Jenner A, Zuleger T, Proikas-Cezanne T, Villunger A, García-Sáez AJ (2020). Drp1 modulates mitochondrial stress responses to mitotic arrest. Cell Death Differ. 2020 Mar 19. doi: 10.1038/s41418-020-0527-y . [Epub ahead of print]  
  • Kuwana T, King LE, Cosentino K, Suess J, Garcia-Saez AJ, Gilmore AP, Newmeyer DD (2020). Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization. J Biol Chem. 2020 Feb 7;295(6):1623-1636. doi: 10.1074/jbc.RA119.011635. Epub 2020 Jan 3
  • Flores-Romero H, Ros U, García-Sáez AJ (2020). A lipid perspective on regulated cell death. Int Rev Cell Mol Biol. 2020;351:197-236. doi:10.1016/bs.ircmb.2019.11.004. Epub 2019 Dec 18 
  • García-Sáez AJ (2020). The BCL-2 family saga. Nat Rev Mol Cell Biol. 2020 Jul 22. doi: 10.1038/s41580-020-0276-2. Online ahead of print  
  • Diestelkoetter-Bachert P, Beck R, Reckmann I, Hellwig A, Garcia-Saez A, Zelman-Hopf M, Hanke A, Nunes Alves A, Wade RC, Mayer MP, Wieland F (2020). Structural characterization of an Arf dimer interface: molecular mechanism of Arf-dependent membrane scission. FEBS Lett. 2020 Jul;594(14):2240-2253. PMID: 32394429 DOI: 10.1002/1873-3468.13808  
  • Ros U, Pedrera L, Garcia-Saez AJ (2020). Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis. Int J Mol Sci. 2020 Mar 31;21(7):2412. PMID: 32244433 PMCID: PMC7177786 DOI: 10.3390/ijms21072412  
  • Flores-Romero H, García-Sáez AJ (2020). Lipids glue BAK dimers together. Nat Struct Mol Biol. 2020 Sep 29. doi: 10.1038/s41594-020-00516-y.Online ahead of print. PMID: 32994578
  • Lindenboim L, Grozki D, Amsalem-Zafran AR, Peña-Blanco A, Gundersen GG, Borner C, Hodzic D, Garcia-Sáez AJ, Worman HJ, Stein R (2020). Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins. Cell Death Discov. 2020 Sep 18;6:90. doi: 10.1038/s41420-020-00327-6. eCollection 2020. PMID: 33024575
  • Flores-Romero H, Ros U, Garcia-Saez AJ (2020). Pore formation in regulated cell death. EMBO J. 2020 Oct 30:e105753. doi: 10.15252/embj.2020105753. Online ahead of print. PMID: 33124082 Review
  • Serulla M, Ichim G, Stojceski F, Grasso G, Afonin S, Heulot M, Schober T, Roth R, Godefroy C, Milhiet PE, Das K, García-Sáez AJ, Danani A, Widmann C (2020). TAT-RasGAP_317-326 kills cells by targeting inner-leaflet-enriched phospholipids. Proc Natl Acad Sci U S A. 2020 Nov 30:202014108. doi:10.1073/pnas.2014108117. Online ahead of print. PMID: 33257567
  • Shalaby R, Flores-Romero H, García-Sáez AJ (2020). The Mysteries around the BCL-2 Family Member BOK. Biomolecules. 2020 Dec 4;10(12):E1638. doi: 10.3390/biom10121638. PMID: 33291826 Review 

Martin Graef

  • Schütter M, Giavalisco P, Brodesser S, Graef M (2020). Local fatty acid channeling into phospholipid synthesis drives phagophore expansion during autophagy. Cell. 2020 Jan 9;180(1):135-149.e14. doi: 10.1016/j.cell.2019.12.005. Epub 2019 Dec 26  
  • Gross A, Graef M (2020). Mechanisms of autophagy in metabolic stress response. J Mol Biol. 2020 Jan 3;432(1):28-52. doi: 10.1016/j.jmb.2019.09.005. Epub 2019 Oct 15
  • Sawa-Makarska J, Baumann V, Coudevylle N, von Bülow S, Nogellova V, Abert C, Schuschnig M, Graef M, Hummer G, Martens S (2020). Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation. Science. 2020 Sep 4; 369(6508):eaaz7714. doi:10.1126/science.aaz7714
  • Gross AS, Graef M. (2020). Stress eating: Autophagy targets nuclear pore complexes. J Cell Biol. 2020 Jul 6;219(7):e202006007. doi: 10.1083/jcb.202006007.
  • Graef M. (2020). Recent advances in the understanding of autophagosome biogenesis. F1000Res. 2020 Mar 26;9:F1000 Faculty Rev-212. doi: 10.12688/f1000research.22111.1. eCollection2020.
  • Schütter M, Graef M. (2020). Localized de novo phospholipid synthesis drives autophagosome biogenesis. Autophagy. 2020 Apr;16(4):770-771. doi: 10.1080/15548627.2020.1725379. Epub 2020 Feb 6.

Michael Hallek

  • Abruzzo, L., Herling, C., Coombes, K., Benner, A., Bloehdorn, J., Barron, L.L., Abrams, Z., Majewski, T., Bondaruk, J., Bahlo, J., Fischer, K., Hallek, M., Stilgenbauer, S., Czerniak, B., Oakes, C., Ferrajoli, A., and Keating, M. (2020). Gene expression signatures predict time-to-progression after front-line chemoimmunotherapy for CLL. Leukemia Lymphoma61, 7-8.
  • Agius, R., Brieghel, C., Andersen, M.A., Pearson, A.T., Ledergerber, B., Cozzi-Lepri, A., Louzoun, Y., Andersen, C.L., Bergstedt, J., von Stemann, J.H., Jorgensen, M., Tang, M.H.E., Fontes, M., Bahlo, J., Herling, C.D., Hallek, M., Lundgren, J., MacPherson, C.R., Larsen, J., and Niemann, C.U. (2020). Machine learning can identify newly diagnosed patients with CLL at high risk of infection. Nat Commun11. ARTN 363. 10.1038/s41467-019-14225-8.
  • Al-Sawaf, O., Eichhorst, B., and Hallek, M. (2020). Chronic lymphocytic leukemia. Onkologe26, 465-476. 10.1007/s00761-020-00769-8.
  • Al-Sawaf, O., Lilienweiss, E., Bahlo, J., Robrecht, S., Fink, A.M., Patz, M., Tandon, M., Jiang, Y.W., Schary, W., Ritgen, M., Tausch, E., Stilgenbauer, S., Eichhorst, B., Fischer, K., Hallek, M., and Kreuzer, K.A. (2020). High efficacy of venetoclax plus obinutuzumab in patients with complex karyotype and chronic lymphocytic leukemia. Blood135, 866-870. 10.1182/blood.2019003451.
  • Al-Sawaf, O., Robrecht, S., Bahlo, J., Fink, A.M., Cramer, P., von Tresckow, J., Lange, E., Kiehl, M., Dreyling, M., Rittgen, M., Dürig, J., Fischer, K., Stilgenbauer, S., Wendtner, C., Goede, V., Hallek, M., and Eichhorst, B. (2020). Richter transformation in CLL: a meta-analysis of GCLLSG trials. Leukemia Lymphoma61, 98-100.
  • Al-Sawaf, O., Robrecht, S., Fink, A., Ritgen, M., Johansson, P., Staber, P., Jäger, U., Niemann, C., Pallasch, C., Kreuzer, K., Stilgenbauer, S., Fischer, K., Wendtner, C., Hallek, M., and Eichhorst, B. (2020). The CLL-RT1 trial: A multi-center phase-2 trial to evaluate the efficacy and safety of zanubrutinib, a BTK inhibitor, plus tislelizumab, a PD-1 inhibitor, for treatment of patients with Richter Transformation. Oncol Res Treat43, 73-73.
  • Al-Sawaf, O., Zhang, C., Tandon, M., Sinha, A., Fink, A.M., Robrecht, S., Samoylova, O., Liberati, A.M., Pinilla-Ibarz, J., Opat, S., Sivcheva, L., Le Dû, K., Fogliatto, L.M., Niemann, C.U., Weinkove, R., Robinson, S., Kipps, T.J., Tausch, E., Schary, W., Ritgen, M., Wendtner, C.M., Kreuzer, K.A., Eichhorst, B., Stilgenbauer, S., Hallek, M., and Fischer, K. (2020). Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (CLL14): follow-up results from a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol21, 1188-1200.
  • Al-Sawaf, O., Zhang, C., Tandon, M., Sinha, A., Fink, A.M., Robrecht, S., Tausch, E., Schary, W.L., Ritgen, M., Wendtner, C.M., Kreuzer, K.A., Eichhorst, B., Stilgenbauer, S., Hallek, M.J., Fischer, K., and Investigators, C.S. (2020). Fixed-duration venetoclax-obinutuzumab for previously untreated patients with chronic lymphocytic leukemia: Follow-up of efficacy and safety results from the multicenter, open-label, randomized, phase III CLL14 trial. J Clin Oncol38.
  • Augustin, M., and Hallek, M. (2020). Current study results underline cautious commenting. Internist61, 646-646. 10.1007/s00108-020-00810-3.
  • Augustin, M., Hallek, M., and Nitschmann, S. (2020). Morphological and molecular Changes in the Lungs of COVID-19 Patients. Internist61, 1304-1307. 10.1007/s00108-020-00897-8.
  • Augustin, M., Hallek, M., and Nitschmann, S. (2020). Remdesivir for patients with severe COVID-19. Internist61, 644-645. 10.1007/s00108-020-00800-5.
  • Augustin, M., Schommers, P., Suárez, I., Koehler, P., Gruell, H., Klein, F., Maurer, C., Langerbeins, P., Priesner, V., Schmidt-Hellerau, K., Malin, J.J., Stecher, M., Jung, N., Wiesmüller, G., Meissner, A., Zweigner, J., Langebartels, G., Kolibay, F., Suárez, V., Burst, V., Valentin, P., Schedler, D., Cornely, O.A., Hallek, M., Fätkenheuer, G., Rybniker, J., and Lehmann, C. (2020). Rapid response infrastructure for pandemic preparedness in a tertiary care hospital: lessons learned from the COVID-19 outbreak in Cologne, Germany, February to March 2020. Eurosurveillance25, 6-12. 10.2807/1560-7917.Es.2020.25.21.2000531.
  • Barbarino, V., Henschke, S., Blakemore, S.J., Izquierdo, E., Michalik, M., Nickel, N., Möllenkotte, I., Vorholt, D., Müller, L., Brinker, R., Fedorchenko, O., Mikhael, N., Seeger-Nukpezah, T., Hallek, M., and Pallasch, C.P. (2020). Macrophage-Mediated Antibody Dependent Effector Function in Aggressive B-Cell Lymphoma Treatment is Enhanced by Ibrutinib via Inhibition of JAK2. Cancers12. ARTN 2303. 10.3390/cancers12082303.
  • Barthel, R., Fedorchenko, O., Velmans, T., Rosen, N., Nguyen, P.H., Reinart, N., Florin, A., Herling, M., Hallek, M., and Fingerle-Rowson, G. (2020). CD74 is dispensable for development of chronic lymphocytic leukemia in Eµ-TCL1 transgenic mice. Leukemia Lymphoma61, 2799-2810. 10.1080/10428194.2020.1791851.
  • Borchmann, P., Jühling, A., Gödel, P., Balke-Want, H., Schmid, C., Ayuk, F., Holtkamp, S., Preussner, L., Zadoyan, G., Hanssens, L., Kaiser, A., Jurk, M., Burger, I., Schneider, D., Dropulic, B., Overstijns, T., Holtick, U., Scheid, C., Miltenyi, S., and Hallek, M. (2020). Phase I trial of MB-CART2019.1, a novel CD20 and CD19 targeting tandem chimeric antigen receptor, in patients with relapsed or refractory B-cell Non-Hodgkin Lymphoma. Oncol Res Treat43, 56-56.
  • Borchmann, P., Kobe, C., Plütschow, A., Greil, R., Meissner, J., Topp, M.S., Ostermann, H., Dierlamm, J., Mohm, J., Thiemer, J., Sökler, M., Kerkhoff, A., Ahlborn, M., Halbsguth, T., Martin, S., Keller, U., Balabanov, S., Pabst, T., Vogelhuber, M., Hüttmann, A., Wilhem, M., Zijlstra, J.M., Moccia, A., Bröckelmann, P.J., von Tresckow, B., Fuchs, M., Eich, H., Baues, C., Hallek, M., Diehl, V., Dietlein, M., and Engert, A. (2020). Positron emission tomography guided omission of radiotherapy in early-stage unfavorable Hodgkin Lymphoma: Final results of the international, randomized Phase III HD17 trial by the German Hodgkin Study Group. Oncol Res Treat43, 32-32.
  • Braun, F., Rinschen, M., Buchner, D., Bohl, K., Plagmann, I., Bachurski, D., Späth, M., Antczak, P., Göbel, H., Klein, C., Lackmann, J.W., Kretz, O., Puelles, V.G., Wahba, R., Hallek, M., Schermer, B., Benzing, T., Huber, T.B., Beyer, A., Stippel, D., Kurschat, C.E., and Müller, R.U. (2020). The proteomic landscape of small urinary extracellular vesicles during kidney transplantation. Journal of Extracellular Vesicles10. ARTN e12026. 10.1002/jev2.12026.
  • Condoluci, A., di Bergamo, L.T., Langerbeins, P., Hoechstetter, M.A., Herling, C.D., De Paoli, L., Delgado, J., Rabe, K.G., Gentile, M., Doubek, M., Mauro, F.R., Chiodin, G., Mattsson, M., Bahlo, J., Cutrona, G., Kotaskova, J., Deambrogi, C., Smedby, K.E., Spina, V., Bruscaggin, A., Wu, W., Moia, R., Bianchi, E., Gerber, B., Zucca, E., Gillessen, S., Ghielmini, M., Cavalli, F., Stussi, G., Hess, M.A., Baumann, T.S., Neri, A., Ferrarini, M., Rosenquist, R., Forconi, F., Foà, R., Pospisilova, S., Morabito, F., Stilgenbauer, S., Döhner, H., Parikh, S.A., Wierda, W.G., Montserrat, E., Gaidano, G., Hallek, M., and Rossi, D. (2020). International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia. Blood135, 1859-1869. DOI 10.1182/blood.2019003453.
  • Cramer, P., von Tresckow, J., Eichhorst, B., and Hallek, M. (2020). Current Diagnosis and Treatment of Chronic Lymphocytic Leukaemia. Deut Med Wochenschr145, 1139-1144. 10.1055/a-1039-8472.
  • Edelmann, J., Holzmann, K., Tausch, E., Saunderson, E.A., Jebaraj, B.M.C., Steinbrecher, D., Dolnik, A., Blätte, T.J., Landau, D.A., Saub, J., Estenfelder, S., Ibach, S., Cymbalista, F., Leblond, V., Delmer, A., Bahlo, J., Robrecht, S., Fischer, K., Goede, V., Bullinger, L., Wu, C.J., Mertens, D., Ficz, G., Gribben, J.G., Hallek, M., Döhner, H., and Stilgenbauer, S. (2020). Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription. Haematologica105, 1379-1390. 10.3324/haematol.2019.217307.
  • Fink, A.M., Robrecht, S., Bahlo, J., Fürstenau, M., Aldaoud, A., Hebart, H., Jentsch-Ullrich, K., Dörfel, S., Fischer, K., Wendtner, C.M., Nösslinger, T., Ghia, P., Kater, A., Kreuzer, K.A., Tausch, E., Stilgenbauer, S., Rittgen, M., Boettcher, S., Eichhorst, B., and Hallek, M. (2020). Long-term efficacy and safety of maintenance with lenalidomide in patients with chronic lymphocytic leukaemia and a high risk of progression after first-line immunochemotherapy. Leukemia Lymphoma61, 272-273.
  • Fischer, K., Al-Sawaf, O., and Hallek, M. (2020). Preventing and monitoring for tumor lysis syndrome and other toxicities of venetoclax during treatment of chronic lymphocytic leukemia. Hematol-Am Soc Hemat, 357-362. 10.1182/hematology.2020000120.
  • Fraser, G., Chanan-Khan, A., Demirkan, F., Silva, R.S., Grosicki, S., Janssens, A., Mayer, J., Bartlett, N., Dilhuydy, M.S., Loscertales, J., Avigdor, A., Rule, S., Samoilova, O., Pavlosky, M., Hallek, M., Salman, M., Tamegnon, M., Sun, S., Connor, A., Nottage, K., Balasubramanian, S., Howes, A., and Cramer, P. (2020). Final 5-year updated results from a phase 3 study (HELIOS) of ibrutinib plus bendamustine and rituximab (BR) in patients with relapsed/refractory chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Leukemia Lymphoma61, 106-108.
  • Fraser, G.A.M., Chanan-Khan, A., Demirkan, F., Silva, R.S., Grosicki, S., Janssens, A., Mayer, J., Bartlett, N.L., Dilhuydy, M.S., Loscertales, J., Avigdor, A., Rule, S., Samoilova, O., Pavlovsky, M.A., Goy, A., Mato, A., Hallek, M., Salman, M., Tamegnon, M., Sun, S., Connor, A., Nottage, K., Schuier, N., Balasubramanian, S., Howes, A., and Cramer, P. (2020). Final 5-year findings from the phase 3 HELIOS study of ibrutinib plus bendamustine and rituximab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma. Leukemia Lymphoma61, 3188-3197. 10.1080/10428194.2020.1795159.
  • Fuerstenau, M., Hopfinger, G., Robrecht, S., Fink, A.M., Al-Sawaf, O., Langerbeins, P., Cramer, P., Von Tresckow, J., Maurer, C., Kutsch, N., Hoechstetter, M., Dreyling, M., Lange, E., Kneba, M., Stilgenbauer, S., Doehner, H., Hensel, M., Kiehl, M.G., Jaeger, U., Wendtner, C.M., Goede, V., Fischer, K., von Bergwelt-Baildon, M., Eichhorst, B., Hallek, M., and Theurich, S. (2020). Influence of obesity and gender on treatment outcomes in patients with chronic lymphocytic leukemia (CLL) undergoing rituximab-based chemoimmunotherapy. Leukemia34, 1177-1181. 10.1038/s41375-019-0630-6.
  • Fürstenau, M., Bahlo, J., Fink, A.M., Lange, E., Dreger, P., Dreyling, M., Hess, G., Ritgen, M., Kneba, M., Döhner, H., Stilgenbauer, S., Wendtner, C.M., Goede, V., Fischer, K., Böttcher, S., Hallek, M., and Eichhorst, B. (2020). Residual abdominal lymphadenopathy after intensive frontline chemoimmunotherapy is associated with inferior outcome independently of minimal residual disease status in chronic lymphocytic leukemia. Leukemia34, 924-928. 10.1038/s41375-019-0597-3.
  • Fürstenau, M., Langerbeins, P., De Silva, N., Fink, A.M., Robrecht, S., von Tresckow, J., Simon, F., Hohloch, K., Droogendijk, J., van der Klift, M., van der Spek, E., Illmer, T., Schöttker, B., Fischer, K., Wendtner, C.M., Tausch, E., Stilgenbauer, S., Niemann, C.U., Gregor, M., Kater, A.P., Hallek, M., and Eichhorst, B. (2020). COVID-19 among fit patients with CLL treated with venetoclax-based combinations. Leukemia34, 2225-2229. 10.1038/s41375-020-0941-7.
  • Fürstenau, M., Simon, F., Cornely, O.A., Hicketier, T., Eichhorst, B., Hallek, M., and Mellinghoff, S.C. (2020). Invasive Aspergillosis in Patients Treated With Ibrutinib. Hemasphere4. ARTN e309. 10.1097/HS9.0000000000000309.
  • Ghia, P., Coutre, S.E., Cheson, B.D., Barrientos, J.C., Hillmen, P., Pettitt, A.R., Zelenetz, A.D., Shreay, S., Hallek, M., and Furman, R.R. (2020). Impact of idelalisib on health-related quality of life in patients with relapsed chronic lymphocytic leukemia in a phase III randomized trial. Haematologica105, E519-E522. 10.3324/haematol.2019.238808.
  • Grossek, A., Oberste, M., Bloch, W., Wolf, F., Hallek, M., Elter, T., and Zimmer, P. (2020). Evaluating The Suitability Of A Graded Exercise Test In Patients With Acute Leukemia Or Lymphoma. Med Sci Sport Exer52, 332-332.
  • Hallek, M. (2020). Non-cellular immunotherapy in oncology. Internist61, 651-651. 10.1007/s00108-020-00817-w.
  • Hansen, H.P., Leme, A.F.P., and Hallek, M. (2020). Role of ADAM10 as a CD30 Sheddase in Classical Hodgkin Lymphoma. Frontiers in Immunology11. ARTN 398. 10.3389/fimmu.2020.00398.
  • Herling, C.D., Cymbalista, F., Gross-Ophoff-Müller, C., Bahlo, J., Robrecht, S., Langerbeins, P., Fink, A.M., Al-Sawaf, O., Busch, R., Porcher, R., Cazin, B., Dreyfus, B., Ibach, S., Leprêtre, S., Fischer, K., Kaiser, F., Eichhorst, B., Wentner, C.M., Hoechstetter, M.A., Döhner, H., Leblond, V., Kneba, M., Letestu, R., Böttcher, S., Stilgenbauer, S., Hallek, M., and Levy, V. (2020). Early treatment with FCR versus watch and wait in patients with stage Binet A high-risk chronic lymphocytic leukemia (CLL): a randomized phase 3 trial. Leukemia34, 2038-2050. 10.1038/s41375-020-0747-7.
  • Hoechstetter, M.A., Busch, R., Eichhorst, B., Buhler, A., Winkler, D., Bahlo, J., Robrecht, S., Eckart, M.J., Vehling-Kaiser, U., Jacobs, G., Jäger, U., Hurtz, H.J., Hopfinger, G., Hartmann, F., Fuss, H., Abenhardt, W., Blau, I., Freier, W., Müller, L., Goebeler, M., Wendtner, C., Fischer, K., Herling, C.D., Starck, M., Bentz, M., Emmerich, B., Döhner, H., Stilgenbauer, S., and Hallek, M. (2020). Prognostic model for newly diagnosed CLL patients in Binet stage A: results of the multicenter, prospective CLL1 trial of the German CLL study group. Leukemia34, 1038-1051. 10.1038/s41375-020-0727-y.
  • Holtick, U., Herling, M., Frenzel, L.P., Herling, C., Schiller, J., Aguilar, M.R.C., Theurich, S., Hallek, M., and Scheid, C. (2020). A Phase II Study to Investigate the Efficacy of shortterm Everolimus in Addition to post-transplant Cyclophosphamide as graft-versus-host-prophylaxis after Allogeneic Stem Cell Transplantation (Octet-ever). Bone Marrow Transpl55, 290-291.
  • Jakobs, F., Drost, R.M.W.A., Kron, A., Heinen, J., Hallek, M., Reinhardt, H.C., Zander, T., and Kron, F. (2020). Economic Impact of the Introduction of Outpatient Medical Specialist Care (ASV) of Gastrointestinal Cancer Patients from a German Hospital Management Perspective. Oncol Res Treat43, 498-504. 10.1159/000509618.
  • Jaramillo, S., Agathangelidis, A., Schneider, C., Bahlo, J., Robrecht, S., Tausch, E., Bloehdorn, J., Hoechstetter, M., Fischer, K., Eichhorst, B., Goede, V., Hallek, M., Döhner, H., Rosenquist, R., Ghia, P., Stamatopoulos, K., and Stilgenbauer, S. (2020). Prognostic impact of prevalent chronic lymphocytic leukemia stereotyped subsets: analysis within prospective clinical trials of the German CLL Study Group. Haematologica105, 2598-2607. 10.3324/haematol.2019.231027.
  • Jenniches, I., Lemmen, C., Cwik, J.C., Kusch, M., Labouvie, H., Scholten, N., Gerlach, A., Stock, S., Samel, C., Hagemeier, A., Hellmich, M., Haas, P., Hallek, M., Pfaff, H., and Dresen, A. (2020). Evaluation of a complex integrated, cross-sectoral psycho-oncological care program (isPO): a mixed-methods study protocol. Bmj Open10. ARTN e034141. 10.1136/bmjopen-2019-034141.
  • Knuever, J., Weiss, J., Persa, O.D., Kreuzer, K., Mauch, C., Hallek, M., and Schlaak, M. (2020). The use of circulating cell-free tumor DNA in routine diagnostics of metastatic melanoma patients. Sci Rep-Uk10. ARTN 4940. 10.1038/s41598-020-61818-1.
  • Koch, M., Hallek, M., and Nguyen, P.H. (2020). Significant sex differences in CLL progression in the Em-TCL1 transgenic mouse model. Leukemia Lymphoma61, 237-238.
  • Koch, M., Reinartz, S., Saggau, J., Knittel, G., Rosen, N., Fedorchenko, O., Thelen, L., Barthel, R., Reinart, N., Seeger-Nukpezah, T., Reinhardt, H.C., Hallek, M., and Nguyen, P.H. (2020). Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Eµ-TCL1 Transgenic Mouse Model. Cancers12. ARTN 1980. 10.3390/cancers12071980.
  • Koehler, P., Cornely, O.A., Bottiger, B.W., Dusse, F., Eichenauer, D.A., Fuchs, F., Hallek, M., Jung, N., Klein, F., Persigehl, T., Rybniker, J., Kochanek, M., Boll, B., and Shimabukuro-Vornhagen, A. (2020). COVID-19 associated pulmonary aspergillosis. Mycoses63, 528-534. 10.1111/myc.13096.
  • Kohlhas, V., Hallek, M., and Nguyen, P.H. (2020). Constitutive activation of Lyn kinase enhances BCR responsiveness, but not the development of CLL in Eµ-TCL1 mice. Blood Adv4, 6106-6116. 10.1182/bloodadvances.2020002584.
  • Krause, G., Hassenrück, F., and Hallek, M. (2020). Relevant Cytokines in the B Cell Lymphoma Micro-Environment. Cancers12. ARTN 2525. 10.3390/cancers12092525.
  • Krause, G., Hassenrück, F., and Hallek, M. (2020). Cell line-based assessment of BTK inhibitors. Brit J Pharmacol177, 2163-2165. 10.1111/bph.14948.
  • Kreuzer, K.A., Furman, R.R., Stilgenbauer, S., Dubowy, R.L., Kim, Y., Munugalavadla, V., Lilienweiss, E., Reinhardt, H.C., Cramer, P., Eichhorst, B., Hillmen, P., O'Brien, S.M., Pettitt, A.R., and Hallek, M. (2020). The impact of complex karyotype on the overall survival of patients with relapsed chronic lymphocytic leukemia treated with idelalisib plus rituximab. Leukemia34, 296-300. 10.1038/s41375-019-0533-6.
  • Kutsch, N., Bahlo, J., Robrecht, S., Franklin, J., Zhang, C., Maurer, C., De Silva, N., Lange, E., Weide, R., Kiehl, M.G., Sökler, M., Schlag, R., Vehling-Kaiser, U., Köchling, G., Köchling, C., Gregor, M., Plesner, T., Herling, M., Fischer, K., Döhner, H., Kneba, M., Wendtner, C.M., Klapper, W., Kreuzer, K.A., Böttcher, S., Stilgenbauer, S., Fink, A.M., Hallek, M., and Eichhorst, B. (2020). Long Term Follow-up Data and Health-Related Quality of Life in Frontline Therapy of Fit Patients Treated With FCR Versus BR (CLL10 Trial of the GCLLSG). Hemasphere4. ARTN e336. 10.1097/HS9.0000000000000336.
  • Langerbeins, P., Bahlo, J., Rhein, C., Gerwin, H., Cramer, P., Fürstenau, M., Al-Sawaf, O., von Tresckow, J., Fink, A.M., Kreuzer, K.A., Vehling-Kaiser, U., Tausch, E., Müller, L., Eckart, M.J., Schlag, R., Freier, W., Gaska, T., Balser, C., Reiser, M., Stauch, M., Wendtner, C.M., Reiser, M., Stauch, M., Fischer, K., Stilgenbauer, S., Eichhorst, B., and Hallek, M. (2020). Ibrutinib versus placebo in patients with asymptomatic, treatment-naive early stage chronic lymphocytic leukemia (CLL): primary endpoint results of the phase 3 double-blind randomized CLL12 trial. Leukemia Lymphoma61, 18-20.
  • Langerbeins, P., Fürstenau, M., Gruell, H., Klein, F., Persigehl, T., Rybniker, J., Seeger-Nukpezah, T., Kochanek, M., Hallek, M., Eichhorst, B., Koehler, P., and Böll, B. (2020). COVID-19 complicated by parainfluenza co-infection in a patient with chronic lymphocytic leukemia. Eur J Haematol105, 508-511. 10.1111/ejh.13475.
  • Montesinos-Rongen, M., Brunn, A., Tuchscherer, A., Borchmann, P., Schorb, E., Kasenda, B., Altmüller, J., Illerhaus, G., Ruge, M.I., Maarouf, M., Büttner, R., Hansmann, M.L., Hallek, M., Prinz, M., Siebert, R., and Deckert, M. (2020). Analysis of Driver Mutational Hot Spots in Blood-Derived Cell-Free DNA of Patients with Primary Central Nervous System Lymphoma Obtained before Intracerebral Biopsy. J Mol Diagn22, 1300-1307. 10.1016/j.jmoldx.2020.07.002.
  • Oberbeck, S., Schrader, A., Warner, K., Jungherz, D., Crispatzu, G., von Jan, J., Chmielewski, M., Ianevski, A., Diebner, H.H., Mayer, P., Ados, A.K., Wahnschaffe, L., Braun, T., Müller, T.A., Wagle, P., Bouska, A., Neumann, T., Pützer, S., Varghese, L., Pflug, N., Thelen, M., Makalowski, J., Riet, N., Göx, H.J.M., Rappl, G., Altmüller, J., Kotrová, M., Persigehl, T., Hopfinger, G., Hansmann, M.L., Schlöer, H., Stilgenbauer, S., Dürig, J., Mougiakakos, D., Von Bergwelt-Baildon, M., Roeder, I., Hartmann, S., Hallek, M., Moriggl, R., Brüggemann, M., Aittokallio, T., Iqbal, J., Newrzela, S., Abken, H., and Herling, M. (2020). Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling. Blood136, 2786-2802. 10.1182/blood.2019003348.
  • Rassaf, T., Totzeck, M., Backs, J., Bokemeyer, C., Hallek, M., Hilfiker-Kleiner, D., Hochhaus, A., Lüftner, D., Müller, O.J., Neudorf, U., Pfister, R., von Haehling, S., Lehmann, L.H., Bauersachs, J., and Me, K.K.K. (2020). Onco-Cardiology Consensus Paper of the German Cardiac Society, the German Society for Pediatric Cardiology and Congenital Heart Defects and the German Society for Hematology and Medical Oncology. Kardiologe14, 267-293. 10.1007/s12181-020-00395-z.
  • Rossi, D., Shadman, M., Condoluci, A., Brown, J.R., Byrd, J.C., Gaidano, G., Hallek, M., Hillmen, P., Mato, A., Montserrat, E., and Ghia, P. (2020). How We Manage Patients With Chronic Lymphocytic Leukemia During the SARS-CoV-2 Pandemic. Hemasphere4. ARTN e432. 10.1097/HS9.0000000000000432.
  • Rothe, A., Classen, A., Carney, J., Hallek, M., Mellinghoff, S.C., Scheid, C., Holtick, U., and von Bergwelt-Baildon, M. (2020). Bridging antifungal prophylaxis with 50 mg or 100 mg micafungin in allogeneic stem cell transplantation: A retrospective analysis. Eur J Haematol104, 291-298. 10.1111/ejh.13372.
  • Segura, S.J., Agathangelidis, A., Schneider, C., Bahlo, J., Robrecht, S., Tausch, E., Bloehdorn, J., Hoechstetter, M., Fischer, K., Eichhorst, B., Goede, V., Hallek, M., Döhner, H., Brandell, R.R., Ghia, P., Stamatopoulos, K., and Stilgenbauer, S. (2020). Prognostic impact of common chronic lymphocytic leukemia stereotyped subsets: analysis within prospective clinical trials of the German CLL Study Group (GCLLSG). Leukemia Lymphoma61, 135-136.
  • Tausch, E., Schneider, C., Robrecht, S., Zhang, C., Dolnik, A., Bloehdorn, J., Bahlo, J., Al-Sawaf, O., Ritgen, M., Fink, A.M., Eichhorst, B., Kreuzer, K.A., Tandon, M., Humphrey, K., Jiang, Y.W., Schary, W., Bullinger, L., Mertens, D., Lurà, M.P., Kneba, M., Döhner, H., Fischer, K., Hallek, M., and Stilgenbauer, S. (2020). Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax. Blood135, 2402-2412. 10.1182/blood.2019004492.
  • Tzaridis, T., Weller, J., Bachurski, D., Schäfer, N., Schaub, C., Hallek, M., Scheffler, B., Glas, M., Hartmann, G., Herrlinger, U., Wild, S., Coch, C., and Reiners, K. (2020). Analysis of Serum Mirna in Glioblastoma Patients: Targeted Enrichment of Extracellular Vesicles Enhances Specificity for Prognostic Signature. Neuro-Oncology22, 10-10.
  • Volz, C., Breid, S., Selenz, C., Zaplatina, A., Golfmann, K., Meder, L., Dietlein, F., Borchmann, S., Chatterjee, S., Siobal, M., Schöttle, J., Florin, A., Koker, M., Nill, M., Ozretic, L., Uhlenbrock, N., Smith, S., Büttner, R., Miao, H., Wang, B.C., Reinhardt, H.C., Rauh, D., Hallek, M., Acker-Palmer, A., Heukamp, L.C., and Ullrich, R.T. (2020). Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC. Cell Rep31. ARTN 107568. 10.1016/j.celrep.2020.107568.

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Robert Hänsel-Hertsch

  • Hansel-Hertsch, R., Simeone, A., Shea, A., Hui, W.W.I., Zyner, K.G., Marsico, G., Rueda, O.M., Bruna, A., Martin, A., Zhang, X., Adhikari, S., Tannahill, D., Caldas, C., and Balasubramanian, S. (2020). Landscape of G-quadruplex DNA structural regions in breast cancer. Nat Genet52, 878-883. 10.1038/s41588-020-0672-8.

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Jan Hoeijmakers

 

  • Bautista-Niño, P.K., Portilla-Fernandez, E., Rubio-Beltrán, E., van der Linden, J.J., de Vries, R., van Veghel, R., de Boer, M., Durik, M., Ridwan, Y., Brandt, R., Essers, J., Menzies, R.I., Thomas, R., de Bruin, A., Duncker, D.J., van Beusekom, H.M.M., Ghanbari, M., Hoeijmakers, J.H.J., Sedlacek, R., Touyz, R.M., Montezano, A.C., van der Pluijm, I., Danser, A.H.J., Haanes, K.A., and Roks, A.J.M. (2020). Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction. Clin Sci134, 727-746. 10.1042/Cs20190124.
  • Kim, D.E., Dollé, M.E.T., Vermeij, W.P., Gyenis, A., Vogel, K., Hoeijmakers, J.H.J., Wiley, C.D., Davalos, A.R., Hasty, P., Desprez, P.Y., and Campisi, J. (2020). Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. Aging Cell19. ARTN e13072. 10.1111/acel.13072.
  • Mkrtchyan, G.V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., de Cabo, R., Campisi, J., Cuervo, A.M., Demaria, M., Ewald, C.Y., Fang, E.F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C.G., Georgievskaya, A., Gladyshev, V.N., Glass, D.J., Gorbunova, V., de Grey, A., He, W.W., Hoeijmakers, J., Hoffmann, E., Horvath, S., Houtkooper, R.H., Jensen, M.K., Jensen, M.B., Kane, A., Kassem, M., de Keizer, P., Kennedy, B., Karsenty, G., Lamming, D.W., Lee, K.F., MacAulay, N., Mamoshina, P., Mellon, J., Molenaars, M., Moskalev, A., Mund, A., Niedernhofer, L., Osborne, B., Pak, H.H., Parkhitko, A., Raimundo, N., Rando, T.A., Rasmussen, L.J., Reis, C., Riedel, C.G., Franco-Romero, A., Schumacher, B., Sinclair, D.A., Suh, Y., Taub, P.R., Toiber, D., Treebak, J.T., Valenzano, D.R., Verdin, E., Vijg, J., Young, S., Zhang, L., Bakula, D., Zhavoronkov, A., and Scheibye-Knudsen, M. (2020). ARDD 2020: from aging mechanisms to interventions. Aging-Us12, 24484-24503. DOI 10.18632/aging.202454.
  • Van den Boogaard, W., Smit, K., Brandt, R., Barnhoorn, S., Rijksen, Y., Tissing, W., Van den Heuvel-Eibrink, M.M., Hoeijmakers, J., and Vermeij, W. (2020). Pre-Treatment Fasting as a Means to Prevent Chemotherapy-Induced Side Effects. Pediatr Blood Cancer67, S29-S29.

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Thorsten Hoppe    

  • Herzog LK, Kevei É, Marchante R, Böttcher C, Bindesbøll C, Lystad AH, Pfeiffer A, Gierisch ME, Salomons FA, Simonsen A, Hoppe T, Dantuma NP (2020). The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy. Aging Cell e13051
  • Fatima A, Irmak D, Noormohammadi A, Rinschen MM, Das A, Leidecker O, Schindler C, Sánchez-Gaya V, Wagle P, Pokrzywa W, Hoppe T, Rada-Iglesias A, Vilchez D (2020). The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Commun Biol. 3: 262
  • Ravanelli S, den Brave F, and Hoppe T (2020). Mitochondrial quality control governed by ubiquitin. Front Cell Dev Biol. 8: 270
  • Balaji V, Hoppe T (2020). Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly. F1000 Biol Rep 9: 88
  • Bayer EA, Stecky RC, Neal L, Katsamba PS, Ahlsen G, Balaji V, Hoppe T, Shapiro L, Oren-Suissa M, Hobert O (2020). Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior. Elife. 2020 Oct 6;9:e59614. doi: 10.7554/eLife.59614. PMID: 33021200
  • Dantuma NP, Hoppe T, Herzog LK (2020). The price of longevity. Aging (Albany NY). 2020 Nov 28. doi: 10.18632/aging.104215. PMID: 33253121
  • Donkervoort S, Kutzner CE, Hu Y, Lornage X, Rendu J, Stojkovic T, Baets J, Neuhaus SB, Tanboon J, Maroofian R, Bolduc V, Mroczek M, Conijn S, Kuntz NL, Töpf A, Monges S, Lubieniecki F, McCarty RM, Chao KR, Governali S, Böhm J, Boonyapisit K, Malfatti E, Sangruchi T, Horkayne-Szakaly I, Hedberg-Oldfors C, Efthymiou S, Noguchi S, Djeddi S, Iida A, di Rosa G, Fiorillo C, Salpietro V, Darin N, Fauré J, Houlden H, Oldfors A, Nishino I, de Ridder W, Straub V, Pokrzywa W, Laporte J, Foley AR, Romero NB, Ottenheijm C, Hoppe T, Bönnemann CG (2020). Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores. Am J Hum Genet. 2020 Nov 17;S0002-9297(20)30399-2. doi: 10.1016/j.ajhg.2020.11.002 
  • Albert MC, Brinkmann K, Pokrzywa W, Günther SD, Krönke M, Hoppe T, Kashkar H (2020). CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis. 2020 Sep 10;11(9):740.  doi: 10.1038/s41419-020-02923-x 
  • Hoppe T, Cohen E (2020). Organismal protein homeostasis mechanisms. Genetics. 2020 Aug; 215(4): 889–901.  Published online 2020 Jun 24. doi: 10.1534/genetics.120.301283
  • Finger, F., Ottens, F., Springhorn, A., Drexel, T., Proksch, L., Metz, S., Cochella, L., and Hoppe, T. (2020). Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling. Nat Metab2, 126. 10.1038/s42255-019-0167-z.
  • Koyuncu, S., Saez, I., Lee, H.J., Gutierrez-Garcia, R., Pokrzywa, W., Fatima, A., Hoppe, T., and Vilchez, D. (2020). Author Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat Commun11, 985. 10.1038/s41467-020-14726-x.

Tamas Horvath      

  • Timper, K., Del Rio-Martin, A., Cremer, A.L., Bremser, S., Alber, J., Giavalisco, P., Varela, L., Heilinger, C., Nolte, H., Trifunovic, A., Horvath, T.L., Kloppenburg, P., Backes, H., and Bruning, J.C. (2020). GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab31, 1189-1205 e1113. 10.1016/j.cmet.2020.05.001.

Pitter Huesgen

  • Hofsetz E, Demir F, Szczepanowska K, Kukat A, Kizhakkedathu JN, Trifunovic A, Huesgen PF (2020). The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis. Mol Cell Proteomics. 2020 Aug;19(8):1330-1345. doi: 10.1074/mcp.RA120.002082. Epub 2020 Nov 23. PMID: 33451507
  • Dall E, Zauner FB, Soh WT, Demir F, Dahms SO, Cabrele C, Huesgen PF, Brandstetter H (2020). Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition. J Biol Chem. 2020 Sep 11;295(37):13047-13064. doi: 10.1074/jbc.RA120.014478. Epub 2020 Jul 21. PMID: 32719006
  • Niedermaier S, Schneider T, Bahl MO, Matsubara S, Huesgen PF (2020). Photoprotective acclimation of the Arabidopsis thaliana leaf proteome to fluctuating light. Front Genet. 2020 Mar 5;11:154. doi: 10.3389/fgene.2020.00154. eCollection 2020. PMID: 32194630
  • Soh WT, Demir F, Dall E, Perrar A, Dahms SO, Kuppusamy M, Brandstetter H, Huesgen PF (2020). ExteNDing proteome coverage with legumain as highly specific digestion protease. Anal Chem. 2020 Feb 18;92(4):2961-2971. doi: 10.1021/acs.analchem.9b03604. Epub 2020 Jan 31. PMID: 31951383

Sandra Iden 

  • Li M, Knapp SK, Iden S (2020). Mechanisms of melanocyte polarity and differentiation: What can we learn from other neuroectoderm-derived lineages? Curr Opin Cell Biol. 2020; 67:99-108. Published online 2020 Oct 21. doi: 10.1016/j.ceb.2020.09.001

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Ron Jachimowicz

  • Bröckelmann PJ, de Jong MRW, Jachimowicz RD (2020). Targeting DNA Repair, Cell Cycle, and Tumor Microenvironment in B Cell Lymphoma. Cells. 2020 Oct 14;9(10):2287. doi: 10.3390/cells9102287. PMID: 33066395 
  • Riabinska A, Lehrmann D, Jachimowicz RD, Knittel G, Fritz C, Schmitt A, Geyer A, Heneweer C, Wittersheim M, Frenzel LP, Torgovnick A, Wiederstein JL, Wunderlich CM, Ortmann M, Paillard A, Wößmann W, Borkhardt A, Burdach S, Hansmann ML, Rosenwald A, Perner S, Mall G, Klapper W, Merseburg A, Krüger M, Grüll H, Persigehl T, Wunderlich FT, Peifer M, Utermöhlen O, Büttner R, Beleggia F, Reinhardt HC (2020). ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia. 2020 Mar;34(3):771-786. doi: 10.1038/s41375-019-0618-2. Epub 2019 Nov 5. PMID: 31690822

Frank Jessen

  • Wang X, Huang W, Su L, Xing Y, Jessen F, Sun Y, Shu N, Han Y (2020). Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease. Mol Neurodegener. 2020 Sep 22;15(1):55. doi: 10.1186/s13024-020-00395-3. PMID: 32962744 Review
  • Jessen F, Kleineidam L, Wolfsgruber S, Bickel H, Brettschneider C, Fuchs A, Kaduszkiewicz H, König HH, Mallon T, Mamone S, Pabst A, Pentzek M, Roehr S, Weeg D, Jochen W, Weyerer S, Wiese B, Maier W, Scherer M, Riedel-Heller S, Wagner M (2020). Prediction of dementia of Alzheimer type by different types of subjective cognitive decline. Alzheimers Dement. 2020 Nov 2. doi: 10.1002/alz.12163. Online ahead of print. PMID: 33140565 
  • Maier F, Spottke A, Bach JP, Bartels C, Buerger K, Dodel R, Fellgiebel A, Fliessbach K, Frölich L, Hausner L, Hellmich M, Klöppel S, Klostermann A, Kornhuber J, Laske C, Peters O, Priller J, Richter-Schmidinger T, Schneider A, Shah-Hosseini K, Teipel S, von Arnim CAF, Wiltfang J, Jessen F (2020). Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020 May 1;3(5):e206027. doi: 10.1001/jamanetworkopen.2020.6027. PMID: 32463470
  • Sannemann L, Schild AK, Altenstein S, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Freiesleben SD, Glanz W, Heneka MT, Janowitz D, Kilimann I, Kobeleva X, Laske C, Metzger CD, Munk MHJ, Perneczky R, Peters O, Polcher A, Priller J, Rauchmann B, Rösch C, Rudolph J, Schneider A, Spottke A, Spruth EJ, Teipel S, Vukovich R, Wagner M, Wiltfang J, Wolfsgruber S, Duezel E, Jessen F; DELCODE Study Group (2020). Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers-results from the DELCODE study. Alzheimers Res Ther. 2020 Oct 16;12(1):131. doi: 10.1186/s13195-020-00701-7. PMID: 33066827
  • Herdick M, Dyrba M, Fritz HJ, Altenstein S, Ballarini T, Brosseron F, Buerger K, Can Cetindag A, Dechent P, Dobisch L, Duezel E, Ertl-Wagner B, Fliessbach K, Dawn Freiesleben S, Frommann I, Glanz W, Dylan Haynes J, Heneka MT, Janowitz D, Kilimann I, Laske C, Metzger CD, Munk MH, Peters O, Priller J, Roy N, Scheffler K, Schneider A, Spottke A, Jakob Spruth E, Tscheuschler M, Vukovich R, Wiltfang J, Jessen F, Teipel S, Grothe MJ (2020). Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer's disease spectrum. Neuroimage Clin. 2020;28:102495. doi: 10.1016/j.nicl.2020.102495. Epub 2020 Nov 11. PMID: 33395986
  • Dafsari, F.S., and Jessen, F. (2020). Depression-an underrecognized target for prevention of dementia in Alzheimer's disease. Transl Psychiatry10, 160. 10.1038/s41398-020-0839-1.
  • Finsterwalder, S., Vlegels, N., Gesierich, B., Araque Caballero, M.A., Weaver, N.A., Franzmeier, N., Georgakis, M.K., Konieczny, M.J., Koek, H.L., Dominantly Inherited Alzheimer, N., Karch, C.M., Graff-Radford, N.R., Salloway, S., Oh, H., Allegri, R.F., Chhatwal, J.P., group, D.s., Jessen, F., Duzel, E., Dobisch, L., Metzger, C., Peters, O., Incesoy, E.I., Priller, J., Spruth, E.J., Schneider, A., Fliessbach, K., Buerger, K., Janowitz, D., Teipel, S.J., Kilimann, I., Laske, C., Buchmann, M., Heneka, M.T., Brosseron, F., Spottke, A., Roy, N., Ertl-Wagner, B., Scheffler, K., Alzheimer's Disease Neuroimaging, I., Utrecht, V.C.I.s.g., Seo, S.W., Kim, Y., Na, D.L., Kim, H.J., Jang, H., Ewers, M., Levin, J., Schmidt, R., Pasternak, O., Dichgans, M., Biessels, G.J., and Duering, M. (2020). Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients. Alzheimers Dement16, 1504-1514. 10.1002/alz.12150.
  • Frisoni, G.B., Molinuevo, J.L., Altomare, D., Carrera, E., Barkhof, F., Berkhof, J., Delrieu, J., Dubois, B., Kivipelto, M., Nordberg, A., Schott, J.M., van der Flier, W.M., Vellas, B., Jessen, F., Scheltens, P., and Ritchie, C. (2020). Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies. Alzheimers Dement16, 1457-1468. 10.1002/alz.12132.
  • Fuentes, M., Klostermann, A., Kleineidam, L., Bauer, C., Schuchhardt, J., Maier, W., Jessen, F., Frolich, L., Wiltfang, J., Kornhuber, J., Kloppel, S., Schieting, V., Teipel, S.J., Wagner, M., and Peters, O. (2020). Identification of a Cascade of Changes in Activities of Daily Living Preceding Short-Term Clinical Deterioration in Mild Alzheimer's Disease Dementia via Lead-Lag Analysis. J Alzheimers Dis76, 1005-1015. 10.3233/JAD-200230.
  • Gaebel, W., Zaske, H., Hesse, K., Klingberg, S., Ohmann, C., Grebe, J., Kolbe, H., Icks, A., Schneider, F., Backes, V., Wolff-Menzler, C., Guse, B., Gallinat, J., Bock, T., Jockers-Scherubl, M.C., Kruger, T., Jessen, F., Bechdolf, A., Kircher, T., Konrad, C., Falkai, P., Schaub, A., Rudolph, M., Kollner, V., Schmid-Ott, G., Linden, M., Lieberei, B., Stuhlinger, M., Sommerfeld, S., Schumacher, A., Krenge, S., Gereke, S., Monter, N., Navarro-Urena, A., Frosch, G., Kuhlbusch, F.J., Cleveland, H., and Riesbeck, M. (2020). Promoting stigma coping and empowerment in patients with schizophrenia and depression: results of a cluster-RCT. Eur Arch Psychiatry Clin Neurosci270, 501-511. 10.1007/s00406-019-01064-3.
  • Jessen, F. (2020). Attention in subjective cognitive decline - Authors' reply. Lancet Neurol19, 566-567. 10.1016/S1474-4422(20)30177-0.
  • Jessen, F., Amariglio, R.E., Buckley, R.F., van der Flier, W.M., Han, Y., Molinuevo, J.L., Rabin, L., Rentz, D.M., Rodriguez-Gomez, O., Saykin, A.J., Sikkes, S.A.M., Smart, C.M., Wolfsgruber, S., and Wagner, M. (2020). The characterisation of subjective cognitive decline. Lancet Neurol19, 271-278. 10.1016/S1474-4422(19)30368-0.
  • Karsak, M., Glebov, K., Scheffold, M., Bajaj, T., Kawalia, A., Karaca, I., Rading, S., Kornhuber, J., Peters, O., Diez-Fairen, M., Frolich, L., Hull, M., Wiltfang, J., Scherer, M., Riedel-Heller, S., Schneider, A., Heneka, M.T., Fliessbach, K., Sharaf, A., Thiele, H., Lennarz, M., Jessen, F., Maier, W., Kubisch, C., Ignatova, Z., Nurnberg, P., Pastor, P., Walter, J., and Ramirez, A. (2020). A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2. Hum Mutat41, 169-181. 10.1002/humu.23904.
  • Kleineidam, L., Chouraki, V., Prochnicki, T., van der Lee, S.J., Madrid-Marquez, L., Wagner-Thelen, H., Karaca, I., Weinhold, L., Wolfsgruber, S., Boland, A., Martino Adami, P.V., Lewczuk, P., Popp, J., Brosseron, F., Jansen, I.E., Hulsman, M., Kornhuber, J., Peters, O., Berr, C., Heun, R., Frolich, L., Tzourio, C., Dartigues, J.F., Hull, M., Espinosa, A., Hernandez, I., de Rojas, I., Orellana, A., Valero, S., Stringa, N., van Schoor, N.M., Huisman, M., Scheltens, P., Alzheimer's Disease Neuroimaging, I., Ruther, E., Deleuze, J.F., Wiltfang, J., Tarraga, L., Schmid, M., Scherer, M., Riedel-Heller, S., Heneka, M.T., Amouyel, P., Jessen, F., Boada, M., Maier, W., Schneider, A., Gonzalez-Perez, A., van der Flier, W.M., Wagner, M., Lambert, J.C., Holstege, H., Saez, M.E., Latz, E., Ruiz, A., and Ramirez, A. (2020). PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. Acta Neuropathol139, 1025-1044. 10.1007/s00401-020-02138-6.
  • Lohrs, L., Handrack, M., Kopp, I., Jessen, F., Wagner, E., Falkai, P., Roh, A., Strube, W., and Hasan, A. (2020). Evaluation of evidence grades in psychiatry and psychotherapy guidelines. BMC Psychiatry20, 503. 10.1186/s12888-020-02897-2.
  • Lopes Alves, I., Collij, L.E., Altomare, D., Frisoni, G.B., Saint-Aubert, L., Payoux, P., Kivipelto, M., Jessen, F., Drzezga, A., Leeuwis, A., Wink, A.M., Visser, P.J., van Berckel, B.N.M., Scheltens, P., Gray, K.R., Wolz, R., Stephens, A., Gismondi, R., Buckely, C., Gispert, J.D., Schmidt, M., Ford, L., Ritchie, C., Farrar, G., Barkhof, F., Molinuevo, J.L., and Consortium, A. (2020). Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study. Alzheimers Dement16, 750-758. 10.1002/alz.12069.
  • Muller, T., Payton, N.M., Kalpouzos, G., Jessen, F., Grande, G., Backman, L., and Laukka, E.J. (2020). Cognitive, Genetic, Brain Volume, and Diffusion Tensor Imaging Markers as Early Indicators of Dementia. J Alzheimers Dis77, 1443-1453. 10.3233/JAD-200445.
  • Rhein, C., Muhle, C., Lenz, B., Richter-Schmidinger, T., Kogias, G., Boix, F., Lourdusamy, A., Dorfler, A., Peters, O., Ramirez, A., Jessen, F., Maier, W., Hull, M., Frolich, L., Teipel, S., Wiltfang, J., Kornhuber, J., and Muller, C.P. (2020). Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly. Brain Res Bull161, 13-20. 10.1016/j.brainresbull.2020.05.001.
  • Rohr, S., Pabst, A., Riedel-Heller, S.G., Jessen, F., Turana, Y., Handajani, Y.S., Brayne, C., Matthews, F.E., Stephan, B.C.M., Lipton, R.B., Katz, M.J., Wang, C., Guerchet, M., Preux, P.M., Mbelesso, P., Ritchie, K., Ancelin, M.L., Carriere, I., Guaita, A., Davin, A., Vaccaro, R., Kim, K.W., Han, J.W., Suh, S.W., Shahar, S., Din, N.C., Vanoh, D., van Boxtel, M., Kohler, S., Ganguli, M., Jacobsen, E.P., Snitz, B.E., Anstey, K.J., Cherbuin, N., Kumagai, S., Chen, S., Narazaki, K., Ng, T.P., Gao, Q., Gwee, X., Brodaty, H., Kochan, N.A., Trollor, J., Lobo, A., Lopez-Anton, R., Santabarbara, J., Crawford, J.D., Lipnicki, D.M., Sachdev, P.S., and for Cohort Studies of Memory in an International, C. (2020). Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimers Res Ther12, 167. 10.1186/s13195-020-00734-y.
  • Rostamzadeh, A., Stapels, J., Genske, A., Haidl, T., Junger, S., Seves, M., Woopen, C., and Jessen, F. (2020). Health Literacy in Individuals at Risk for Alzheimer's Dementia: A Systematic Review. J Prev Alzheimers Dis7, 47-55. 10.14283/jpad.2019.34.
  • Vennedey, V., Peltzer, S., Shukri, A., Muller, H., Jessen, F., Albus, C., and Stock, S. (2020). Comparison of Patient and Proxy Assessment of Patient-Centeredness in the Care of Coronary Heart Disease: A Cross Sectional Survey Using the PACIC-S11.1. J Prim Care Community Health11, 2150132720976235. 10.1177/2150132720976235.
  • Wesselman, L.M.P., Schild, A.K., Hooghiemstra, A.M., Meiberth, D., Drijver, A.J., Leeuwenstijn-Koopman, M.V., Prins, N.D., Brennan, S., Scheltens, P., Jessen, F., van der Flier, W.M., and Sikkes, S.A.M. (2020). Targeting Lifestyle Behavior to Improve Brain Health: User-Experiences of an Online Program for Individuals with Subjective Cognitive Decline. J Prev Alzheimers Dis7, 184-194. 10.14283/jpad.2020.9.
  • Wolfsgruber, S., Kleineidam, L., Guski, J., Polcher, A., Frommann, I., Roeske, S., Spruth, E.J., Franke, C., Priller, J., Kilimann, I., Teipel, S., Buerger, K., Janowitz, D., Laske, C., Buchmann, M., Peters, O., Menne, F., Fuentes Casan, M., Wiltfang, J., Bartels, C., Duzel, E., Metzger, C., Glanz, W., Thelen, M., Spottke, A., Ramirez, A., Kofler, B., Fliessbach, K., Schneider, A., Heneka, M.T., Brosseron, F., Meiberth, D., Jessen, F., Wagner, M., and Group, D.S. (2020). Minor neuropsychological deficits in patients with subjective cognitive decline. Neurology95, e1134-e1143. 10.1212/WNL.0000000000010142.

Hamid Kashkar      

  • Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H (2020). Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat Microbiol. 2020 Feb;5(2):354-367. doi: 10.1038/s41564-019-0620-5 . Epub 2019 Dec 23
  • Haumann S, Boix J, Knuever J, Bieling A, Vila Sanjurjo A, Elson JL, Blakely EL, Taylor RW, Riet N, Abken H, Kashkar H, Hornig-Do HT, Wiesner RJ (2020). Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells. Carcinogenesis. 2020 Dec 31;41(12):1735-1745. doi: 10.1093/carcin/bgaa032
  • Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmidt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D (2020). Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNFR signaling in virus-infected hepatocytes. J Hepatol. 2020 Dec;73(6):1347-1359. doi: 10.1016/j.jhep.2020.06.026. Epub 2020 Jun 26.
  • Schiffmann LM, Werthenbach JP, Heintges-Kleinhofer F, Seeger JM, Fritsch M, Günther SD, Willenborg S, Brodesser S, Lucas C, Jüngst C, Albert MC, Schorn F, Witt A, Moraes CT, Bruns C, Pasparakis M, Krönke M, Eming SA, Coutelle O, Kashkar H (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat Commun. 2020 Jul 21;11(1):3653. doi: 10.1038/s41467-020-17472-2
  • Albert MC, Brinkmann K, Pokrzywa W, Günther SD, Krönke M, Hoppe T, Kashkar H (2020). CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis. 2020 Sep 10;11(9):740. doi: 10.1038/s41419-020-02923-x
  • Mayer CT, Nieke JP, Gazumyan A, Cipolla M, Wang Q, Oliveira YT, Ramos V, Monette S, Li QZ, Gershwin ME, Kashkar H, Nussenzweig MC (2020). An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells. Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24957-24963. doi: 10.1073/pnas.2015372117. Epub 2020 Sep 22
  • Kirschberg M, Heuser S, Marcuzzi GP, Hufbauer M, Seeger JM, Dukic A, Tomaic V, Majewski S, Wagner S, Wittekindt C, Würdemann N, Klussmann JP, Quaas A, Kashkar H, Akgül B (2020). ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers. Sci Rep. 2020 Oct 15;10(1):17339.  doi: 10.1038/s41598-020-74311-6.

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Martin Krönke

  • Albert, M.C., Brinkmann, K., Pokrzywa, W., Günther, S.D., Krönke, M., Hoppe, T., and Kashkar, H. (2020). CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis11. ARTN 740. 10.1038/s41419-020-02923-x.
  • El-Hindi, K., Brachtendorf, S., Hartel, J.C., Oertel, S., Birod, K., Trautmann, S., Thomas, D., Ulshöfer, T., Weigert, A., Utermöhlen, O., Krönke, M., and Grösch, S. (2020). Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation. Cancers12. ARTN 1753. 10.3390/cancers12071753.
  • Günther, S.D., Fritsch, M., Seeger, J.M., Schiffmann, L.M., Snipas, S.J., Coutelle, M., Kufer, T.A., Higgins, P.G., Hornung, V., Bernardini, M.L., Höning, S., Krönke, M., Salvesen, G.S., and Kashkar, H. (2020). Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nature Microbiology5, 354-+. 10.1038/s41564-019-0620-5.
  • Hos, N.J., Fischer, J., Hos, D., Hejazi, Z., Calabrese, C., Ganesan, R., Murthy, A.M.V., Rybniker, J., Kumar, S., Krönke, M., and Robinson, N. (2020). TRIM21 Is Targeted for Chaperone-Mediated Autophagy during SalmonellaTyphimurium Infection. J Immunol205, 2456-+. 10.4049/jimmunol.2000048.
  • Lampl, S., Janas, M.K., Donakonda, S., Brugger, M., Lohr, K., Schneider, A., Manske, K., Sperl, L.E., Kläger, S., Küster, B., Wettmarshausen, J., Müller, C., Laschinger, M., Hartmann, D., Hüser, N., Perocchi, F., Schmitt-Kopplin, P., Hagn, F., Zender, L., Hornung, V., Borner, C., Pichlmair, A., Kashkar, H., Klingenspor, M., Prinz, M., Schreiner, S., Conrad, M., Jost, P.J., Zischka, H., Steiger, K., Krönke, M., Zehn, D., Protzer, U., Heikenwälder, M., Knolle, P.A., and Wohlleber, D. (2020). Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. Journal of Hepatology73, 1347-1359. 10.1016/j.jhep.2020.06.026.
  • Peters, F., Tellkamp, F., Brodesser, S., Wachsmuth, E., Tosetti, B., Karow, U., Bloch, W., Utermöhlen, O., Krönke, M., and Niessen, C.M. (2020). Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis. J Invest Dermatol140, 1927-+. 10.1016/j.jid.2020.02.006.
  • Schiffmann, L.M., Werthenbach, J.P., Heintges-Kleinhofer, F., Seeger, J.M., Fritsch, M., Günther, S.D., Willenborg, S., Brodesser, S., Lucas, C., Jüngst, C., Albert, M.C., Schorn, F., Witt, A., Moraes, C.T., Bruns, C.J., Pasparakis, M., Krönke, M., Eming, S.A., Coutelle, O., and Kashkar, H. (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat Commun11. ARTN 3653. 10.1038/s41467-020-17472-2.
  • Tosetti, B., Brodesser, S., Brunn, A., Deckert, M., Blüher, M., Doehner, W., Anker, S.D., Wenzel, D., Fleischmann, B., Pongratz, C., Peters, F., Utermöhlen, O., and Krönke, M. (2020). A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle. Aging Cell19. ARTN e13049. 10.1111/acel.13049.

Peter Kloppenburg

  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532 
  • Lippert RN, Hess S, Klemm P, Burgeno LM, Jahans-Price T, Walton ME, Kloppenburg P, Brüning JC (2020). Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. J Clin Invest. 2020 Jul 1;130(7):3761-3776. doi: 10.1172/JCI134412. PMID: 32510473 
  • Reinoß P, Ciglieri E, Minére M, Bremser S,  Klein A, Löhr H, Fuller PM, Büschges A, Kloppenburg P, Fenselau H, Hammerschmidt M (2020). Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits. Curr Biol. 2020 Dec 7;30(23):4579-4593.e7. doi: 10.1016/j.cub.2020.08.103. Epub 2020 Sep 24 
  • Minassian A, Green C, Diedenhofen M, Vogel S, Hess S, Stoeber M, Radmilovic MD, Wiedermann D, Kloppenburg P, Hoehn M (2020) Human Neural Stem Cell Induced Functional Network Stabilization After Cortical Stroke: A Longitudinal Resting-State fMRI Study in Mice. Front Cell Neurosci. 2020 Apr 7;14:86. doi: 10.3389/fncel.2020.00086. eCollection 2020 
  • Timper K, del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC (2020). GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab. 2020 Jun 2;31(6):1189-1205.e13. doi: 10.1016/j.cmet.2020.05.001. Epub 2020 May 19

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Natalia Kononenko

  • Bera, S., Camblor-Perujo, S., Barca, E.C., Negrete-Hurtado, A., Racho, J., De Bruyckere, E., Wittich, C., Ellrich, N., Martins, S., Adjaye, J., and Kononenko, N.L. (2020). AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons. Embo Rep21. ARTN e47954. 10.15252/embr.201947954.
  • Negrete-Hurtado A, Overhoff M, Bera S, De Bruyckere E, Schätzmüller K, Kye MJ, Qin C, Lammers M, Kondylis V, Neundorf I, Kononenko N (2020). Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons. Nat Commun. 2020; 11: 1535. Published online 2020 Mar 24. doi: 10.1038/s41467-020-15287-9  
  • Sanchez-Mendoza, E.H., Camblor-Perujo, S., Nascentes-Melo, L.M., Dzyubenko, E., Fleischer, M., de Carvalho, T.S., Schmitt, L.I., Leo, M., Hagenacker, T., Herring, A., Keyvani, K., Bera, S., Kononenko, N., Kleinschnitz, C., and Hermann, D.M. (2020). Compromised Hippocampal Neuroplasticity in the Interferon-α and Toll-like Receptor-3 Activation-Induced Mouse Depression Model. Molecular Neurobiology57, 3171-3182. 10.1007/s12035-020-01927-0.

Tatiana Korotkova

  • Heikenfeld, C., Mederos, S., Chen, C.W., Korotkova, T., Schnitzler, A., and Ponomarenko, A. (2020). Prefrontal - subthalamic pathway supports action selection in a spatial working memory task. Sci Rep-Uk10. ARTN 10497. 10.1038/s41598-020-67185-1.
  • Jais, A., Paeger, L., Sotelo-Hitschfeld, T., Bremser, S., Prinzensteiner, M., Klemm, P., Mykytiuk, V., Widdershooven, P.J.M., Vesting, A.J., Grzelka, K., Minere, M., Cremer, A.L., Xu, J., Korotkova, T., Lowell, B.B., Zeilhofer, H.U., Backes, H., Fenselau, H., Wunderlich, F.T., Kloppenburg, P., and Bruning, J.C. (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron106, 1009-1025 e1010. 10.1016/j.neuron.2020.03.022.

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Thomas Krieg

  • Juche, A., Siegert, E., Mueller-Ladner, U., Riemekasten, G., Günther, C., Kotter, I., Henes, J., Blank, N., Voll, R.E., Ehrchen, J., Schmalzing, M., Susok, L., Schmeiser, T., Sunderkoetter, C., Distler, J., Worm, M., Kreuter, A., Horváth, N., Schön, M.P., Korsten, P., Zeidler, G., Pfeiffer, C., Krieg, T., Hunzelmann, N., and Moinzadeh, P. (2020). Reality of inpatient vasoactive treatment with prostacyclin derivatives in patients with acral circulation disorders due to systemic sclerosis in Germany. Z Rheumatol79, 1057-1066. 10.1007/s00393-019-00743-9.
  • Kreuter, M., Bonella, F., Blank, N., Siegert, E., Henes, J., Worm, M., Sunderkoetter, C., Schmalzing, M., Kreuter, A., Guenther, C., Susok, L., Zeidler, G., Koetter, I., Mueller-Ladner, U., Krieg, T., Juche, A., Schmeiser, T., Riemekasten, G., Aberer, E., Gaebelein-Wissing, N., Distler, J.H.W., Sárdy, M., Pfeiffer, C., Kuhr, K., Lorenz, H.M., Moinzadeh, P., and Hunzelmann, N. (2020). Long term outcomes of immunmodulatory drugs in SSc-ILD - data rom the German SSc network. Pneumologie74, S55-S55. 10.1055/s-0039-3403182.
  • Kreuter, M., Bonella, F., Blank, N., Siegert, E., Henes, J., Worm, M., Sunderkoetter, C., Schmalzing, M., Kreuter, A., Guenther, C., Susok, L., Zeidler, G., Koetter, I., Mueller-Ladner, U., Krieg, T., Juche, A., Schmeiser, T., Riemekasten, G., Aberer, E., Gaebelein-Wissing, N., Distler, J.H.W., Sárdy, M., Pfeiffer, C., Kuhr, K., Lorenz, H.M., Moinzadeh, P., and Hunzelmann, N. (2020). Does anti-acid treatment influence disease progression in SSc-ILD? Data form the German SSc-network. Pneumologie74, S55-S55. 10.1055/s-0039-3403181.
  • Matucci-Cerinic, M., Bruni, C., Allanore, Y., Clementi, M., Dagna, L., Damjanov, N.S., de Paulis, A., Denton, C.P., Distler, O., Fox, D., Furst, D.E., Khanna, D., Krieg, T., Kuwana, M., Lee, E.B., Li, M.T., Pillai, S., Wang, Y.K., Zeng, X.F., and Taliani, G. (2020). Systemic sclerosis and the COVID-19 pandemic: World Scleroderma Foundation preliminary advice for patient management. Ann Rheum Dis79, 724-726. 10.1136/annrheumdis-2020-217407.
  • Moinzadeh P, Frommolt P, Franitza M, Toliat MR, Becker K, Nürnberg P, Nihtyanova SI, Ahrazoglu M, Belz D, Hunzelmann N, Abraham D, Ong VH, Mouthon L, Hesselstrand R, Denton CP, Krieg T (2020). Whole blood gene expression profiling distinguishes systemic sclerosis-overlap syndromes from other subsets. J Eur Acad Dermatol Venereol. 2020 May;34(5):e236-e238. doi: 10.1111/jdv.16198. Epub 2020 Feb 19. PMID: 31945216
  • Moinzadeh, P., Kuhr, K., Siegert, E., Blank, N., Sunderkoetter, C., Henes, J., Krusche, M., Schmalzing, M., Worm, M., Schmeiser, T., Günther, C., Aberer, E., Susok, L., Riemekasten, G., Kreuter, A., Zeidler, G., Juche, A., Hadjiski, D., Müller-Ladner, U., Gaebelein-Wissing, N., Distler, J.H.W., Sárdy, M., Krieg, T., and Hunzelmann, N. (2020). Scleroderma Renal Crisis: Risk Factors for an Increasingly Rare Organ Complication. J Rheumatol47, 241-248. 10.3899/jrheum.180582.
  • Moinzadeh, P., Kuhr, K., Siegert, E., Mueller-Ladner, U., Riemekasten, G., Günther, C., Koetter, I., Henes, J., Blank, N., Zeidler, G., Pfeiffer, C., Juche, A., Jandova, I., Ehrchen, J., Schmalzing, M., Susok, L., Schmeiser, T., Sunderkoetter, C., Distler, J.H.W., Worm, M., Kreuter, A., Krieg, T., Hunzelman, N., and Syst, R.G.N. (2020). Older age onset of systemic sclerosis - accelerated disease progression in all disease subsets. Rheumatology59, 3380-3389. 10.1093/rheumatology/keaa127.
  • Schönborn K, Willenborg S, Schulz JN, Imhof T, Eming SA, Quondamatteo F, Brinckmann J, Niehoff A, Paulsson M, Koch M, Eckes B, Krieg T (2020). Role of Collagen XII in skin homeostasis and repair. Matrix Biol. 2020 Sep 2:S0945-053X(20)30087-1. doi: 10.1016/j.matbio.2020.08.002.
  • Zheng, B.Y., Wang, M.B., McKenna, K., Shapiro, L., Spiera, R., Silver, R., Csuka, M.E., van den Hoogen, F., Robinson, D., Hummers, L., Krieg, T., Del Galdo, F., Jones, N., Khalidi, N., Vacca, A., Gordon, J., Pauling, J., and Baron, M. (2020). Agreement Between Physician Evaluation and the Composite Response Index in Diffuse Cutaneous Systemic Sclerosis (CRISS). Arthritis Rheumatol72.

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Martin Krönke

  • Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H (2020). Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat Microbiol. 2020 Feb;5(2):354-367. doi: 10.1038/s41564-019-0620-5 . Epub 2019 Dec 23  
  • Hos NJ, Fischer J, Hos D, Hejazi Z, Calabrese C, Ganesan R, Murthy AMV, Rybniker J, Kumar S, Krönke M, Robinson N (2020). TRIM21 Is Targeted for Chaperone-Mediated Autophagy during SalmonellaTyphimurium Infection.  J Immunol. 2020 Sep 18:ji2000048. doi: 10.4049/jimmunol.2000048. Online ahead of print. PMID: 32948684 
  • Tosetti B, Brodesser S, Brunn A, Deckert M, Blüher M, Doehner W, Anker SD, Wenzel D, Fleischmann B, Pongratz C, Peters F, Utermöhlen O, Krönke M (2020). A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle. Aging Cell. 2020 Jan;19(1):e13049. doi: 10.1111/acel.13049. Epub 2019 Nov 6. PMID: 31692231
  • Schiffmann LM, Werthenbach JP, Heintges-Kleinhofer F, Seeger JM, Fritsch M, Günther SD, Willenborg S, Brodesser S, Lucas C, Jüngst C, Albert MC, Schorn F, Witt A, Moraes CT, Bruns CJ, Pasparakis M, Krönke M, Eming SA, Coutelle O, Kashkar H (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat Commun. 2020 Jul 21;11(1):3653.  doi: 10.1038/s41467-020-17472-2 
  • Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Utermöhlen O, Krönke M, Niessen CM (2020). Murine epidermal ceramide synthase 4 is a key regulator of skin barriere homeostasis. J Invest Dermatol. 2020 Oct;140(10):1927-1937.e5. doi: 10.1016/j.jid.2020.02.006. Epub 2020 Feb 22
  • Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D (2020). Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. J Hepatol. 2020 Dec;73(6):1347-1359. doi: 10.1016/j.jhep.2020.06.026. Epub 2020 Jun 26  
  • El-Hindi K, Brachtendorf S, Hartel JC, Oertel S, Birod K, Trautmann S, Thomas D, Ulshöfer T, Weigert A, Utermöhlen O, Krönke M, Grösch S. Cancers (2020). Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation. Cancers (Basel). 2020 Jul 1;12(7):1753. doi: 10.3390/cancers12071753

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Marcus Krüger

  • Pla-Martín D, Schatton D, Wiederstein JL, Marx MC, Khiati S, Krüger M, Rugarli EI (2020). CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy. EMBO J. 2020 May 4;39(9):e102731. doi: 10.15252/embj.2019102731. Epub 2020 Mar 9. PMID: 32149416 
  • Tellkamp F, Lang F, Ibáñez A, Abraham L, Quezada G, Günther S, Looso M, Tann FJ, Müller D, Cemic F, Hemberger J, Steinfartz S, Krüger M (2020). Proteomics of Galápagos Marine Iguanas Links Function of Femoral Gland Proteins to the Immune System. Mol Cell Proteomics. 2020 Sep;19(9):1523-1532. doi: 10.1074/mcp.RA120.001947. Epub 2020 Nov 25. PMID: 33451733
  • Loescher CM, Breitkreuz M, Li Y, Nickel A, Unger A, Dietl A, Schmidt A, Mohamed BA, Kötter S, Schmitt JP,Krüger M, Krüger M, Toischer K, Maack C, Leichert LI, Hamdani N, Linke WA (2020). Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx). Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24545-24556. doi: 10.1073/pnas.2004900117. Epub 2020 Sep 14
  • Gerbracht JV, Boehm V, Britto-Borges T, Kallabis S, Wiederstein JL, Ciriello S, Aschemeier DU, Krüger M, Frese CK, Altmüller J, Dieterich C, Gehring NH (2020). CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex. Nucleic Acids Res. 2020 Sep 4; 48(15): 8626–8644. Published online 2020 Jul 4. doi: 10.1093/nar/gkaa564
  • Solagna F, Nogara L, Dyar KA, Greulich F, Mir AA, Türk C, Bock T, Geremia A, Baraldo M, Sartori R, Farup J, Uhlenhaut H, Vissing K, Krüger M, Blaauw B (2020). Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling. Acta Physiol (Oxf). 2020 Sep;230(1):e13496. doi: 10.1111/apha.13496. Epub 2020 May 30
  • Herwig M, Kolijn D, Lódi M, Hölper S, Kovács Á, Papp Z, Jaquet K, Haldenwang P, Dos Remedios C, Reusch PH, Mügge A, Krüger M, Fielitz J, Linke WA, Hamdani N (2020). Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D. Front Physiol. 2020; 11: 240. Published online 2020 Apr 15. doi: 10.3389/fphys.2020.00240
  • Sreenivasan K, Ianni A, Künne C, Strilic B, Günther S, Perdiguero E, Krüger M, Spuler S, Offermanns S, Gómez-del Arco P, Redondo JM, Munoz-Canoves P, Kim J, Braun T (2020). Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles. Cell Rep. 2020 May 19;31(7):107652. doi: 10.1016/j.celrep.2020.107652
  • Kallabis S, Abraham L, Müller S, Dzialas V, Türk C, Wiederstein JL, Bock T, Nolte H, Nogara L, Blaauw B, Braun T, Krüger M (2020). High-throughput proteomics fiber typing (ProFiT) for comprehensive characterization of single skeletal muscle fibers. Skelet Muscle. 2020 Mar 23;10(1):7. doi: 10.1186/s13395-020-00226-5
  • Laurien L, Nagata M, Schünke H, Delanghe T, Wiederstein JL, Kumari S, Schwarzer R, Corona T, Krüger M, Bertrand MJM, Kondylis V, Pasparakis M(2020).Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nat Commun. 2020 Apr 8;11(1):1747. doi: 10.1038/s41467-020-15466-8
  • Li M, Nishio SY, Naruse C, Riddell M, Sapski S, Katsuno T, Hikita T, Mizapourshafiyi F, Smith FM, Cooper LT, Lee MG, Asano M, Boettger T, Krüger M, Wietelmann A, Graumann J, Day BW, Boyd AW, Offermanns S, Kitajiri SI, Usami SI, Nakayama M (2020). Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome. Nat Commun. 2020 Mar 12;11(1):1343. doi: 10.1038/s41467-020-15198-9
  • Troidl K, Hammerschick T, Albarrán-Juárez J, Jung G, Schierling W, Tonack S, Krüger M, Matuschke B, Troidl C, Schaper W, Schmitz-Rixen T, Preissner KT, Fischer S (2020). Shear Stress-Induced miR-143-3p in Collateral Arteries Contributes to Outward Vessel Growth by Targeting Collagen V-α2. Arterioscler Thromb Vasc Biol. 2020 May;40(5):e126-e137. doi: 10.1161/ATVBAHA.120.313316. Epub 2020 Mar 19
  • Baraldo M, Geremia A, Pirazzini M, Nogara L, Solagna F, Türk C, Nolte H, Romanello V, Megighian A, Boncompagni S, Krüger M, Sandri M, Blaauw B (2020). Skeletal muscle mTORC1 regulates neuromuscular junction stability. J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):208-225. doi: 10.1002/jcsm.12496. Epub 2019 Oct 25
  • Riabinska A, Lehrmann D, Jachimowicz RD, Knittel G, Fritz C, Schmitt A, Geyer A, Heneweer C, Wittersheim M, Frenzel LP, Torgovnick A, Wiederstein JL, Wunderlich CM, Ortmann M, Paillard A, Wößmann W, Borkhardt A, Burdach S, Hansmann ML, Rosenwald A, Perner S, Mall G, Klapper W, Merseburg A, Krüger M, Grüll H, Persigehl T, Wunderlich FT, Peifer M, Utermöhlen O, Büttner R, Beleggia F, Reinhardt HC (2020). ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia. 2020 Mar;34(3):771-786. doi: 10.1038/s41375-019-0618-2. Epub 2019 Nov 5

Leo Kurian

  • Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon HB, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA (2020). Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. Commun Biol. 2020 May 26;3(1):265. doi: 10.1038/s42003-020-0987-0

Michael Lammers 

  • Negrete-Hurtado A, Overhoff M, Bera S, De Bruyckere E, Schätzmüller K, Kye MJ, Qin C, Lammers M, Kondylis V, Neundorf I, Kononenko N (2020). Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons. Nat Commun. 2020; 11: 1535. Published online 2020 Mar 24. doi: 10.1038/s41467-020-15287-9 

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Thomas Langer

  • Deshwal, S., Fiedler, K.U., and Langer, T.  (2020). Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity. Annu Rev Biochem89, 501-528. 10.1146/annurev-biochem-062917-012739.
  • Murschall LM, Gerhards A, MacVicar T, Peker E, Hasberg L, Wawra S, Langer T, Riemer J (2020). The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import. BMC Biol. 18, 96. https://doi.org/10.1186/s12915-020-00824-1.
  • Ohba, Y., MacVicar, T., and Langer, T.  (2020). Regulation of mitochondrial plasticity by the i-AAA protease YME1L. Biol Chem401, 877-890. 10.1515/hsz-2020-0120.

Maria Leptin

  • Kakanj P, Eming SA, Partridge L, Leptin M (2020). Long-term in vivo imaging of Drosophila larvae. Nat Protoc. 2020 Feb 10. doi: 10.1038/s41596-019-0282-z. [Epub ahead of print]
  • Mathew, R., Rios-Barrera, L.D., Machado, P., Schwab, Y., and Leptin, M. (2020). Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism. Embo J39. ARTN e105332. DOI 10.15252/embj.2020105332.
  • Suurväli, J., Whiteley, A.R., Zheng, Y.C., Gharbi, K., Leptin, M., and Wiehe, T. (2020). The Laboratory Domestication of Zebrafish: From Diverse Populations to Inbred Substrains. Mol Biol Evol37, 1056-1069. 10.1093/molbev/msz289.

Ivan Matic

  • Bonfiglio JJ, Leidecker O, Dauben H, Longarini EJ, Colby T, Segundo-Acosta PS, Perez KS, Matic I (2020). An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation. Cell. 2020 Nov 12;183(4):1086-1102.e23.  doi: 10.1016/j.cell.2020.09.055.

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Roman-Ulrich Müller

  • Schermer B, Fabretti F, Damagnez M, Di Cristanziano V, Heger E, Arjune S, Tanner NA, Imhof T, Koch M, Ladha A, Joung J, Gootenberg JS, Abudayyeh OO, Burst V, Zhang F, Klein F, Benzing T, Müller RU (2020). Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay. PLoS One. 2020 Nov 2;15(11):e0238612. doi: 10.1371/journal.pone.0238612. eCollection 2020. PMID: 33137122
  • Johnsen M, Kubacki T, Yeroslaviz A, Späth MR, Mörsdorf J, Göbel H, Bohl K, Ignarski M, Meharg C, Habermann B, Altmüller J, Beyer A, Benzing T, Schermer B, Burst V, Müller RU (2020). The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury. J Am Soc Nephrol. 31 (2020), 716–730. doi.org/10.1681/ASN.2019050534
  • Grundmann F, Müller RU, Hoyer-Allo KJR, Späth MR, Passmann E, Becker I, Pfister R, Baldus S, Benzing T, Burst V (2020). Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial. Sci Rep 10 (2020), 5202. doi.org/10.1038/s41598-020-61895-2
  • Janssens P, Jouret F, Bammens B, Liebau MC, Schaefer F, Dandurand A, Perrone RD, Müller RU, Pao CS, Mekahli D (2020). Implications of early diagnosis of autosomal dominant polycystic kidney disease: A post hoc analysis of the TEMPO 3:4 trial. Sci Rep. 10 (2020), 4294. doi.org/10.1038/s41598-020-61303-9
  • Siedek F, Grundmann F, Weiss K, Pinto Dos Santos D, Arjune S, Haneder S, Persigehl T, Müller RU, Baessler B (2020). Magnetic Resonance Kidney Parenchyma-T2 as a Novel Imaging Biomarker for Autosomal Dominant Polycystic Kidney Disease. Invest Radiol. (2020) doi.org/10.1097/RLI.0000000000000633 
  • Braun F, Rinschen M, Buchner D, Bohl K, Plagmann I, Bachurski D, Richard Späth M, Antczak P, Göbel H, Klein C, Lackmann JW, Kretz O, Puelles VG, Wahba R, Hallek M, Schermer B, Benzing T, Huber TB, Beyer A, Stippel D, Kurschat CE, Müller RU (2020). The proteomic landscape of small urinary extracellular vesicles during kidney transplantation. J Extracell Vesicles. 2020 Oct;10(1):e12026. doi: 10.1002/jev2.12026. Epub 2020 Nov 19. PMID: 33304478 
  • Kaiser RWJ, Erber J, Höpker K, Fabretti F, MuellerRU (2020). AATF/Che-1 - an RNA binding protein at the nexus of DNA damage response and ribosome biogenesis. Front Oncol. 2020; 10: 919. Published online 2020 Jun 10. doi: 10.3389/fonc.2020.00919 
  • Muller, R.U., and Schermer, B. (2020). Hippo signaling-a central player in cystic kidney disease? Pediatr Nephrol35, 1143-1152. 10.1007/s00467-019-04299-3.

Carien Niessen

  • Rübsam M, Niessen CM (2020). Stretch exercises for stem cells expand the skin. Nature. Aug 584(7820): 196-198. doi: 10.1038/d41586-020-02158-y.
  • Green KJ, Roth-Carter Q, Niessen CM, Nichols SA (2020). Tracing the Evolutionary Origin of Desmosomes. Curr Biol. 2020 May 18;30(10):R535-R543. doi: 10.1016/j.cub.2020.03.047. PMID: 3242849
  • Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA (2020). Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052. Epub 2020 Apr 16. PMID: 32302590
  • Sahu P, Sussman DM, Rübsam M, Mertz AF, Horsley V, Dufresne ER, Niessen CM, Marchetti MC, Manning ML, Schwarz JM (2020). Small-scale demixing in confluent biological tissues. Soft Matter. 2020 Apr 1;16(13):3325-3337. doi: 10.1039/c9sm01084j. PMID: 32196025
  • Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Utermöhlen O, Krönke M, Niessen CM (2020). Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis. J Invest Dermatol. 2020 Feb 22:S0022-202X(20)30160-3. doi: 10.1016/j.jid.2020.02.006. Online ahead of print. PMID: 32092351
  • Bayliss R, Wheeldon J, Caucheteux SM, Niessen CM, Piguet V (2020). Identification of Host Trafficking Genes Required for HIV-1 Virological Synapse Formation in Dendritic Cells. J Virol. 2020 Apr 16;94(9):e01597-19. doi: 10.1128/JVI.01597-19. Print 2020 Apr 16. PMID: 32075937
  • Polányi L, Niessen CM, Vohlen C, Stinn J, Kretschmer T, Jentgen V, Hirani D, Koningsbruggen-Rietschel SV, Dötsch J, Alejandre Alcazar MA (2020). Intrauterine growth restriction induces skin inflammation, increases TSLP and impairs epidermal barrier function. J Mol Med (Berl). 2020 Feb;98(2):279-289. doi: 10.1007/s00109-019-01867-w. Epub 2020 Jan 7. PMID: 31912169 
  • Niessen CM, Plachta N (2020).  Emerging mechanisms driving cell differentiation in vivo. Curr Opin Cell Biol. 2020 Nov 10:S0955-0674(20)30138-1. doi: 10.1016/j.ceb.2020.10.003. Online ahead of print. PMID: 33187809

Linda Partridge

  • Kakanj P, Eming SA, Partridge L, Leptin M (2020). Long-term in vivo imaging of Drosophila larvae. Nat Protoc. 2020 Mar;15(3):1158-1187. doi: 10.1038/s41596-019-0282-z. Epub 2020 Feb 10. PMID: 32042177
  • Cox LS, Bellantuono I, Lord JM, Sapey E, Mannick JB, Partridge L, Gordon AL, Steves CJ, Witham MD (2020). Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults. Lancet Healthy Longev. 2020 Nov;1(2):e55-e57. doi: 10.1016/S2666-7568(20)30011-8. Epub 2020 Nov 9. PMID: 33521768
  • Bjedov I, Cochemé HM, Foley A, Wieser D, Woodling NS, Castillo-Quan JI, Norvaisas P, Lujan C, Regan JC, Toivonen JM, Murphy MP, Thornton J, Kinghorn KJ, Neufeld TP, Cabreiro F, Partridge L (2020). Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. PLoS Genet. 2020 Nov 30;16(11):e1009083. doi: 10.1371/journal.pgen.1009083. eCollection 2020 Nov. PMID: 33253201
  • Scholes HM, Cryar A, Kerr F, Sutherland D, Gethings LA, Vissers JPC, Lees JG, Orengo CA, Partridge L, Thalassinos K (2020). Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Sci Rep. 2020 Oct 28;10(1):18517. doi: 10.1038/s41598-020-74748-9. PMID: 33116184
  • Ivanov DK, Bostelmann G, Lan-Leung B, Williams J, Partridge L, Escott-Price V, Thornton JM (2020). A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data. PLoS One. 2020 Oct 26;15(10):e0240824. doi: 10.1371/journal.pone.0240824. eCollection 2020. PMID: 33104720
  • Woodling NS, Rajasingam A, Minkley LJ, Rizzo A, Partridge L (2020). Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling. BMC Biol. 2020 Sep 14;18(1):124. doi: 10.1186/s12915-020-00854-9. PMID: 32928209
  • Weigelt CM, Sehgal R, Tain LS, Cheng J, Eßer J, Pahl A, Dieterich C, Grönke S, Partridge L (2020). An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila. Mol Cell. 2020 Jul 16;79(2):268-279.e5. doi: 10.1016/j.molcel.2020.06.011. Epub 2020 Jun 26. PMID: 32592682
  • Yu Y, Niccoli T, Ren Z, Woodling NS, Aleyakpo B, Szabadkai G, Partridge L (2020). PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity. Hum Mol Genet. 2020 Aug 11;29(14):2420-2434. doi: 10.1093/hmg/ddaa125. PMID: 32592479
  • Partridge L, Fuentealba M, Kennedy BK (2020). The quest to slow ageing through drug discovery. Nat Rev Drug Discov. 2020 Aug;19(8):513-532. doi: 10.1038/s41573-020-0067-7. Epub 2020 May 28. PMID: 32467649 Review.
  • Woodling NS, Aleyakpo B, Dyson MC, Minkley LJ, Rajasingam A, Dobson AJ, Leung KHC, Pomposova S, Fuentealba M, Alic N, Partridge L (2020). The neuronal receptor tyrosine kinase Alk is a target for longevity. Aging Cell. 2020 May;19(5):e13137. doi: 10.1111/acel.13137. Epub 2020 Apr 15. PMID: 32291952
  • Juricic, P., Grönke, S., and Partridge, L. (2020). Branched-Chain Amino Acids Have Equivalent Effects to Other Essential Amino Acids on Lifespan and Aging-Related Traits in. J Gerontol a-Biol75, 24-31. 10.1093/gerona/glz080.
  • Tain, L.S., Jain, C., Nespital, T., Froehlich, J., Hinze, Y., Grönke, S., and Partridge, L. (2020). Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. Aging Cell19. ARTN e13043. 10.1111/acel.13043.

Manolis Pasparakis  

  • Naito MG, Xu D, Amin P, Lee J, Wang H, Li W, Kelliher M, Pasparakis M, Yuan J (2020). Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proc Natl Acad Sci U S A. 2020 Feb 18. pii: 201916427. doi: 10.1073/pnas.1916427117. [Epub ahead of print]   
  • Schwarzer R, Laurien L, Pasparakis M (2020). New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8. Curr Opin Cell Biol. 2020 Mar 9;63:186-193. doi: 10.1016/j.ceb.2020.02.004 . [Epub ahead of print]   
  • Jiao H, Wachsmuth L, Kumari S, Schwarzer R, Lin J, Eren RO, Fisher A, Lane R, Young GR, Kassiotis G, Kaiser WJ, Pasparakis M (2020). Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature. 2020 Apr;580(7803):391-395. doi: 10.1038/s41586-020-2129-8 . Epub 2020 Mar 25  
  • Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, Bongiovanni L, de Bruin A, Scott CL, Saeys Y, Pasparakis M, Bertrand MJM, van Loo G (2020). OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis. Cell Rep. 2020 Feb 18;30(7):2237-2247.e6. doi: 10.1016/j.celrep.2020.01.028 
  • Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M (2020). FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity. 2020 Apr 22. pii: S1074-7613(20)30160-6. doi: 10.1016/j.immuni.2020.04.002. [Epub ahead of print]
  • Laurien L, Nagata M, Schünke H, Delanghe T, Wiederstein JL, Kumari S, Schwarzer R, Corona T, Krüger M, Bertrand MJM, Kondylis V, Pasparakis M (2020). Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nat Commun. 2020 Apr 8;11(1):1747. doi: 10.1038/s41467-020-15466-8 
  • Pedragosa J, Miró-Mur F, Otxoa-de-Amezaga A, Justicia C, Ruíz-Jaén F, Ponsaerts P, Pasparakis M, Planas AM (2020). CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice. J Cereb Blood Flow Metab. 2020 Dec;40(1_suppl):S98-S116. doi: 10.1177/0271678X20909055. Epub 2020 Mar 9. PMID: 32151226
  • Schiffmann LM, Werthenbach JP, Heintges-Kleinhofer F, Seeger JM, Fritsch M, Günther SD, Willenborg S, Brodesser S, Lucas C, Jüngst C, Albert MC, Schorn F, Witt A, Moraes CT, Bruns CJ, Pasparakis M, Krönke M, Eming SA, Coutelle O, Kashkar H (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat Commun. 11, 3653., doi: 10.1038/s41467-020-17472-2. PMID: 32694534
  • Lalaoui, N., Boyden, S.E., Oda, H., Wood, G.M., Stone, D.L., Chau, D., Liu, L., Stoffels, M., Kratina, T., Lawlor, K.E., Zaal, K.J.M., Hoffmann, P.M., Etemadi, N., Shield-Artin, K., Biben, C., Tsai, W.L., Blake, M.D., Kuehn, H.S., Yang, D., Anderton, H., Silke, N., Wachsmuth, L., Zheng, L., Moura, N.S., Beck, D.B., Gutierrez-Cruz, G., Ombrello, A.K., Pinto-Patarroyo, G.P., Kueh, A.J., Herold, M.J., Hall, C., Wang, H.Y., Chae, J.J., Dmitrieva, N.I., McKenzie, M., Light, A., Barham, B.K., Jones, A., Romeo, T.M., Zhou, Q., Aksentijevich, I., Mullikin, J.C., Gross, A.J., Shum, A.K., Hawkins, E.D., Masters, S.L., Lenardo, M.J., Boehm, M., Rosenzweig, S.D., Pasparakis, M., Voss, A.K., Gadina, M., Kastner, D.L., and Silke, J. (2020). Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature577, 103-+. 10.1038/s41586-019-1828-5.
  • Wong, J., Garcia-Carbonell, R., Zelic, M., Ho, S.B., Boland, B.S., Yao, S.J., Desai, S.A., Das, S., Planell, N., Harris, P.A., Font-Burgada, J., Taniguchi, K., Bertin, J., Salas, A., Pasparakis, M., Gough, P.J., Kelliher, M., Karin, M., and Guma, M. (2020). RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation. Cell Mol Gastroenter9, 295-312. 10.1016/j.jcmgh.2019.10.002.

Lena Pernas

  • Machado TS, Carvalho DF, Garcia BM, Zangirolamo AF, Macabelli CH, Sugiyama FHC, Grejo MP, Neto JDA, Ribeiro FKS, Sarapião FD, Meirelle FV, Guimarães FEG, Pernas L, Seneda MM, Chiaratti MR (2020).Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells. FASEB J. doi: 10.1096/fj.201901761R. PMID: 32281181 

Christina Polidori

  • La Colla L, Polidori MC, Di Saverio G, Preziosi G, Mantovani L, Caobelli F (2020). The impact of health worker gap in Italy on the COVID-19 pandemic. A good time to improve the quality of the Italian National Health System (NHS)? J Infect Public Health. 2020 Sep;13(9):1253-1254. doi: 10.1016/j.jiph.2020.06.010. Epub 2020 Jun 15. PMID: 32586683
  • Meyer AM, Wiebe L, Faust M, Chiapponi C, Brinkkötter PT, Polidori MC, Bartram MP (2020). [Cognitive disorder, depression and gait disturbance in an internal medicine patient-geriatric syndromes in an acute care hospital]. Z Gerontol Geriatr. 2020 Nov 13. doi: 10.1007/s00391-020-01811-5. Online ahead of print. PMID: 33185719 German.
  • Meyer AM, Becker I, Siri G, Brinkkötter PT, Benzing T, Pilotto A, Polidori MC (2020). The prognostic significance of geriatric syndromes and resources. Aging Clin Exp Res. 2020; 32(1):115-124
  • Pilotto A, Custodero C, Cella A, Polidori MC, Maggi S, Ferrucci L (2020). A multidimensional approach to frailty in older people. Ageing Res Rev. 2020 Mar 21;60:101047
  • Dias I, Polidori MC, Griffiths HR (2020). Inflammation, lipid peroxidation and redox regulation. Antioxidants and Redox Signaling, Forum Issue “Inflammation”. Inflammation and related diseases: redox-based mechanisms and energy management. Antioxid Redox Signal. 2020 Feb 28
  • Meyer AM, Podolski N, Pickert L, Polidori MC (2020). Strategies to prevent age-related cognitive decline.Dtsch Med Wochenschr. 2020 Feb;145(3):146-150
  • Cruz-Jentoft AJ, Daragjati J, Fratiglioni L, Maggi S, Mangoni AA, Mattace-Raso F, Paccalin M, Polidori MC, Topinkova E, Ferrucci L, Pilotto A on behalf of the MPI_AGE Investigators (2020). New Horizons in Comprehensive Geriatric Assessment: the Multidimensional Prognostic Index (MPI). Results and Recommendations from the MPI_AGE Project. Aging Clin Exp Res. 2020 Mar 16
  • Ungar A, Rivasi G, Petrovic M, Schönenberger A, Martínez-Sellés M, Gasowski J, Bahat-Ozturk G, Bo M, Dallmaier D, Fumagalli S, Grodzicki T, Kotovskaya Y, Maggi S, Raso FM, Polidori MC, Rajkumar R, Strandberg T, Werner N, Benetos A; From the EuGMS Special Interest Group on Cardiovascular Medicine (2020). Toward a geriatric approach to patients with advanced age and cardiovascular diseases: position statement of the EuGMS Special Interest Group on Cardiovascular Medicine.Eur Geriatr Med. 2020 Feb;11(1):179-184
  • Polidori MC, Maggi S, Mattace Raso F, Pilotto A (2020). The unavoidable costs of frailty: a geriatric perspective in the time of COVID-19. Geriatric Care. 2020; 6: 8989
  • Custodero C, Cella A, Veronese N, Azzini M, Fimognari F, Mattace-Raso F, Polidori MC, Sabbà C, Pilotto A. (2020). The Multidimensional Prognostic Index (MPI) for the prognostic stratification of hospitalized older patients with COVID-19: a prospective multicenter observational cohort study. Objectives, study design and expected outcomes (MPI_COVID-19). Geriatric Care.doi.org/10.4081/gc.2020.9038
  • Jacobs AH, Emmert K, Baron R, Bartsch T, Bauer J, Becker C, Berg D, Bergmann P, Boetzel K, Bollheimer C, Deuschl G, Djukic M, Drey M,  Durwen H, Ebersbach G, Elshehabi M, Geritz J, Gisinger C, Guennewig T,  Hauptmann B, Heppner HJ, Hobert MA, Hofmann W, Huellemann P, Jahn K, Klucken J, Kurth R, Lindner R, Lingor P, Lukas A, Maetzold S, Mokrusch T, Mollenhauer B, Nau R, Plate A, Polidori MC, Prell T, Schellinger P, Schuetze S, Spira D, Stephani U, Studt S, Trenkwalder C, Unger HL, Urban P, von Arnim C, Warnecke T, Weiss M, Wiedemann A, Wirth R, Witt K, Dodel R, Maetzler W (2020). Neurogeriatrics – a vision for improved care and research for geriatric patients with leading neurological disabilities. Z Gerontol Geriatr. 2020 (53) 340-346
  • Falkenreck JM, Roheger M,Weigert H,Friese A,Jahr P, Becker I,Nelles G,Kalbe E,Polidori MC (2020). BrainProtect® - a cognitive training program with nutritional and physical counseling components: a retrospective analysis of its effects in healthy individuals. Geriatric Care. doi.org/10.4081/gc.2020.9328
  • Polidori MC Section Editor. Ageing Medicine and Geriatrics. In: Encyclopedia of Gerontology and Population Aging. Gu D and Dupre M Eds. Springer 2020
  • Senin U, Polidori MC, Cherubini A, Mecocci P (2020). Paziente Anziano Paziente Geriatrico Medicina della Complessitá. Fondamenti di Gerontologia e Geriatria. Eds. 4th Edition, Edises, Napoli 2020

Simon Pöpsel

  • Finogenova K, Bonnet J, Poepsel S, Schäfer IB, Finkl K, Schmid K, Litz C, Strauss M, Benda C, Müller J (2020). Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3. Elife. 2020 Nov 19;9:e61964. doi: 10.7554/eLife.61964. 

Alvaro Rada-Iglesias

  • Bastida, M.F., Pérez-Gómez, R., Trofka, A., Zhu, J.J., Rada-Iglesias, A., Sheth, R., Stadler, H.S., Mackem, S., and Ros, M.A. (2020). The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. P Natl Acad Sci USA117, 1090-1096. 10.1073/pnas.1919470117.
  • Boles, N.C., Fernandes, M., Swigut, T., Srinivasan, R., Schiff, L., Rada-Iglesias, A., Wang, Q.J., Saini, J.S., Kiehl, T., Stern, J.H., Wysocka, J., Blenkinsop, T.A., and Temple, S. (2020). Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide. Stem Cell Reports14, 631-647. 10.1016/j.stemcr.2020.03.009.
  • Fatima, A., Irmak, D., Noormohammadi, A., Rinschen, M.M., Das, A., Leidecker, O., Schindler, C., Sánchez-Gaya, V., Wagle, P., Pokrzywa, W., Hoppe, T., Rada-Iglesias, A., and Vilchez, D. (2020). The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Communications Biology3. ARTN 262.10.1038/s42003-020-0984-3.
  • Hollstein, R., Schröder, J., Welzenbach, J., Bartusel, M., Rada-Iglesias, A., and Ludwig, K.U. (2020). Unraveling genomic interactions at nsCL/P associated GWAS loci using Circular Chromosome Conformation Capture (4C). Eur J Hum Genet28, 569-570.
  • Sánchez-Gaya, V., Mariner-Faulí, M., and Rada-Iglesias, A. (2020). Rare or Overlooked? Structural Disruption of Regulatory Domains in Human Neurocristopathies. Frontiers in Genetics11. ARTN 688. 10.3389/fgene.2020.00688.

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Hans Christian Reinhardt

  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hoevelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling CD, Hartmann E, Rosenwald A, Klapper W, Buettner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt C, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2020). -Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood. 2020 Nov 2:blood.2020005734. doi: 10.1182/blood.2020005734. Online ahead of print. PMID: 33140819 
  • Reimann M, Schrezenmeier JF, Richter-Pechanska P, Dolnik A, Hick TP, Schleich K, Cai X, Fan DNY, Lohneis P, Masswig S, Denker S, Busse A, Knittel G, Flümann R, Childs D, Childs L, Gätjens-Sanchez AM, Bullinger L, Rosenwald A, Reinhardt HC, Schmitt CA (2020). Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas. Blood. 2020 Nov 24:blood.2020005244. doi: 10.1182/blood.2020005244. Online ahead of print. PMID: 33232972  
  • Zimmer Y, Reinhardt HC, Medová M (2020). Editorial: Exploiting DNA Damage Response in the Era of Precision Oncology. Front Oncol. 2020 Oct 15;10:611127. doi: 10.3389/fonc.2020.611127. eCollection 2020. PMID: 33178619  
  • Chen Y, Hoffmeister LM, Zaun Y, Arnold L, Schmid KW, Giebel B, Klein-Hitpass L, Hanenberg H, Squire A, Reinhardt HC, Dührsen U, Bertram S, Hanoun M (2020). Acute myeloid leukemia-induced remodeling of the human bone marrow niche predicts clinical outcome. Blood Adv. 2020 Oct 27;4(20):5257-5268. doi: 10.1182/bloodadvances.2020001808. PMID: 33108453 
  • Jakobs F, Drost RMWA, Kron A, Heinen J, Hallek M, Reinhardt HC, Zander T, Kron F (2020). Economic Impact of the Introduction of Outpatient Medical Specialist Care (ASV) of Gastrointestinal Cancer Patients from a German Hospital Management Perspective. Oncol Res Treat. 2020;43(10):498-505. doi: 10.1159/000509618. Epub 2020 Sep 21. PMID: 32957103 
  • Gremke N, Polo P, Dort A, Schneikert J, Elmshäuser S, Brehm C, Klingmüller U, Schmitt A, Reinhardt HC, Timofeev O, Wanzel M, Stiewe T (2020). mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Nat Commun. 2020 Sep 17;11(1):4684. doi: 10.1038/s41467-020-18504-7. PMID: 32943635  
  • Johansson P, Klein-Hitpass L, Röth A, Möllmann M, Reinhardt HC, Dührsen U, Dürig J (2020). Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype complicating alemtuzumab treatment in T-cell prolymphocytic leukemia. Eur J Haematol. 2020 Dec;105(6):786-796. doi: 10.1111/ejh.13511. Epub 2020 Sep 28. PMID: 32875608 
  • Schödel P, Jünger ST, Wittersheim M, Reinhardt HC, Schmidt NO, Goldbrunner R, Proescholdt M, Grau S (2020). Surgical resection of symptomatic brain metastases improves the clinical status and facilitates further treatment. Cancer Med. 2020 Oct;9(20):7503-7510. doi: 10.1002/cam4.3402. Epub 2020 Aug 28. PMID: 32858763  
  • Klein S, Quaas A, Noh KW, Cartolano M, Abedpour N, Mauch C, Quantius J, Reinhardt HC, Buettner R, Peifer M, Helbig D (2020). Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy. Clin Cancer Res. 2020 Nov 1;26(21):5638-5645. doi: 10.1158/1078-0432.CCR-20-1899. Epub 2020 Aug 17. PMID: 32817080 
  • Kong YW, Dreaden EC, Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz ÖH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB (2020). Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Nat Commun. 2020 Aug 17;11(1):4124. doi: 10.1038/s41467-020-17958-z. PMID: 32807787 
  • Koch M, Reinartz S, Saggau J, Knittel G, Rosen N, Fedorchenko O, Thelen L, Barthel R, Reinart N, Seeger-Nukpezah T, Reinhardt HC, Hallek M, Nguyen PH (2020). Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Eµ-TCL1Transgenic Mouse Model. Cancers (Basel). 2020 Jul 20;12(7):1980. doi: 10.3390/cancers12071980. PMID: 32698538
  • Spiro JE, Rinneburger M, Hedderich DM, Jokic M, Reinhardt HC, Maintz D, Palmowski M, Persigehl T (2020). Monitoring treatment effects in lung cancer-bearing mice: clinical CT and clinical MRI compared to micro-CT. Eur Radiol Exp. 2020 May 13;4(1):31. doi: 10.1186/s41747-020-00160-7. PMID: 32399584  
  • Jachimowicz RD, Pieper L, Reinke S, Gontarewicz A, Plütschow A, Haverkamp H, Frauenfeld L, Fend F, Overkamp M, Jochims F, Thorns C, Hansmann ML, Möller P, Rosenwald A, Stein H, Reinhardt HC, Borchmann P, von Tresckow B, Engert A, Klapper W (2020). Analysis of the tumor microenvironment by whole-slide image analysis identifies low B cell content as a predictor of adverse outcome in advanced-stage classical Hodgkin lymphoma treated with BEACOPP. Haematologica. 2020 May 7. doi: 10.3324/haematol.2019.243287. Online ahead of print. PMID: 32381573  
  • Volz C, Breid S, Selenz C, Zaplatina A, Golfmann K, Meder L, Dietlein F, Borchmann S, Chatterjee S, Siobal M, Schöttle J, Florin A, Koker M, Nill M, Ozretić L, Uhlenbrock N, Smith S, Büttner R, Miao H, Wang B, Reinhardt HC, Rauh D, Hallek M, Acker-Palmer A, Heukamp LC, Ullrich RT (2020). Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC. Cell Rep. 2020 Apr 28;31(4):107568. doi: 10.1016/j.celrep.2020.107568. PMID: 32348765 
  • Flümann R, Nieper P, Reinhardt HC, Knittel G (2020). New murine models of aggressive lymphoma. Leuk Lymphoma. 2020 Apr;61(4):788-798. doi: 10.1080/10428194.2019.1691200. Epub 2019 Nov 22. PMID: 31752573
  • Bendell JC, Bischoff HG, Hwang J, Reinhardt HC, Zander T, Wang X, Hynes S, Pitou C, Campbell R, Iversen P, Farrington DL, Bell-McGuinn K, Thomas M (2020). A phase 1 dose-escalation study of checkpoint kinase 1 (CHK1) inhibitor prexasertib in combination with p38 mitogen-activated protein kinase (p38 MAPK) inhibitor ralimetinib in patients with advanced or metastatic cancer. Invest New Drugs. 2020 Aug;38(4):1145-1155. doi: 10.1007/s10637-019-00873-6. Epub 2019 Nov 9. PMID: 31707688 
  • Riabinska A, Lehrmann D, Jachimowicz RD, Knittel G, Fritz C, Schmitt A, Geyer A, Heneweer C, Wittersheim M, Frenzel LP, Torgovnick A, Wiederstein JL, Wunderlich CM, Ortmann M, Paillard A, Wößmann W, Borkhardt A, Burdach S, Hansmann ML, Rosenwald A, Perner S, Mall G, Klapper W, Merseburg A, Krüger M, Grüll H, Persigehl T, Wunderlich FT, Peifer M, Utermöhlen O, Büttner R, Beleggia F, Reinhardt HC (2020). ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia. 2020 Mar;34(3):771-786. doi: 10.1038/s41375-019-0618-2. Epub 2019 Nov 5. PMID: 31690822 
  • Kreuzer KA, Furman RR, Stilgenbauer S, Dubowy RL, Kim Y, Munugalavadla V, Lilienweiss E, Reinhardt HC, Cramer P, Eichhorst B, Hillmen P, O'Brien SM, Pettitt AR, Hallek M (2020). The impact of complex karyotype on the overall survival of patients with relapsed chronic lymphocytic leukemia treated with idelalisib plus rituximab. Leukemia. 2020 Jan;34(1):296-300. doi: 10.1038/s41375-019-0533-6. Epub 2019 Aug 19. PMID: 31427720 

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Jan Riemer

  • Finger Y, Habich M, Gerlich S, Urbanczyk S, Logt E, Koch J, Schu L, Lapacz KJ, Ali M, Petrungaro C, Salscheider SL, Pichlo C, Baumann U, Mielenz D, Brachvogel B, Hofmaann K, Riemer J (2020). Proteasomal degradation induced by DPP9‐mediated processing competes with mitochondrial protein import. EMBO J. 2020 Oct 1; 39(19): e103889. 2020 Aug 20. doi: 10.15252/embj.2019103889  
  • Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A (2020). A salvage pathway maintains highly functional respiratory complex I. Nat Commun. 2020 Apr 2;11(1):1643. doi: 10.1038/s41467-020-15467-7 
  • Murschall LM, Gerhards A, MacVicar T, Peker E, Hasberg L, Wawra S, Langer T, Riemer J (2020). The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import. BMC Biol. 2020 Aug 6;18(1):96. doi.org/10.1186/s12915-020-00824-1 
  • Finger Y, Riemer J (2020). Protein import by the mitochondrial disulfide relay in higher eukaryotes. Biol Chem. 2020 May 26;401(6-7):749-763. doi: 10.1515/hsz-2020-0108  
  • Stavru F, Riemer J, Jex A, Sassera D (2020). When bacteria meet mitochondria: The strange case of the tick symbiont Midichloria mitochondrii. Cell Microbiol. 2020 Apr;22(4):e13189. doi: 10.1111/cmi.13189

Nirmal Robinson

  • Hos NJ, Fischer J, Hos D, Hejazi Z, Calabrese C, Ganesan R, Murthy AMV, Rybniker J, Kumar S, Krönke M, Robinson N (2020). TRIM21 Is Targeted for Chaperone-Mediated Autophagy during SalmonellaTyphimurium Infection.  J Immunol. 2020 Sep 18:ji2000048. doi: 10.4049/jimmunol.2000048. Online ahead of print. PMID: 32948684 
  • Kew C, Huang W, Fischer J, Ganesan R, Robinson N, Antebi A (2020). Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60. Elife. 2020 Jun 15;9:e57591. doi: 10.7554/eLife.57591

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Elena Rugarli

  • Pla-Martín D, Schatton D, Wiederstein JL, Marx MC, Khiati S, Krüger M, Rugarli EI (2020). CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy. EMBO J. 2020 May 4;39(9):e102731. doi: 10.15252/embj.2019102731. Epub 2020 Mar 9. PMID: 32149416 
  • Tadepalle N, Robers L, Veronese M, Zentis P, Babatz F, Brodesser S, Gruszczyk AV, Schauss A, Hoening S, Rugarli EI (2020). Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.Life Sci Alliance. 2020 Apr 22;3(6):e202000715.  doi: 10.26508/lsa.202000715. Print 2020 Jun

Björn Schumacher

  • Lopes AFC, Bozek K, Herholz M, Trifunovic A, Rieckher M, Schumacher B (2020). A C. elegans model for neurodegeneration in Cockayne syndrome. Nucleic Acids Res. 2020, gkaa795, doi.org/10.1093/nar/gkaa795
  • Umansky C, Morellato A, Scheidegger M, Rieckher M, Martinefski MR, Fernandez GA, Kolesnikova K, Vesting AJ, Karakasilioti I, Reingruber H, Wei Y, He R, Bollini M, Monge ME, Schumacher B, Pontel LB (2020). Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption. BioRxiv 2020; dio doi.org/10.1101/2020.05.14.090738    
  • Bansal A, Neuhaus R, Izquierdo-Alvarez E, Vorholt D, Feldkötter H, Nolte H, Lohneis P, Büttner R, Krüger M, Pallasch CP, Schumacher B (2020). ATM-mediated DNA damage response in macrophages primes phagocytosis and immune checkpoint regulation. BioRxiv 2020; doi: doi.org/10.1101/2020.03.14.987438   
  • Chatzidoukaki O, Goulielmaki E, Schumacher B, Garinis GA (2020). DNA Damage Response and Metabolic Reprogramming in Health and Disease. Trends Genet. 2020 Jul 16:S0168-9525(20)30166-9- doi.org/10.1016/j.tig.2020.06.018  
  • Wang S, Meyer DH, Schumacher B (2020). H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Nat Struct Mol Biol. (2020). doi.org/10.1038/s41594-020-00513-1   
  • Gebel J, Tuppi M, Sänger N, Schumacher B, Dötsch V (2020). DNA Damaged Induced Cell Death in Oocytes. Molecules. 2020 Dec 3;25(23):E5714. doi: 10.3390/molecules25235714Gebel J, Tuppi M, Sänger N, Schumacher B, Dötsch V (2020). DNA Damaged Induced Cell Death in Oocytes. Molecules. 2020 Dec 3;25(23):E5714. doi: 10.3390/molecules25235714
  • Mkrtchyan, G.V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., de Cabo, R., Campisi, J., Cuervo, A.M., Demaria, M., Ewald, C.Y., Fang, E.F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C.G., Georgievskaya, A., Gladyshev, V.N., Glass, D.J., Gorbunova, V., de Grey, A., He, W.W., Hoeijmakers, J., Hoffmann, E., Horvath, S., Houtkooper, R.H., Jensen, M.K., Jensen, M.B., Kane, A., Kassem, M., de Keizer, P., Kennedy, B., Karsenty, G., Lamming, D.W., Lee, K.F., MacAulay, N., Mamoshina, P., Mellon, J., Molenaars, M., Moskalev, A., Mund, A., Niedernhofer, L., Osborne, B., Pak, H.H., Parkhitko, A., Raimundo, N., Rando, T.A., Rasmussen, L.J., Reis, C., Riedel, C.G., Franco-Romero, A., Schumacher, B., Sinclair, D.A., Suh, Y., Taub, P.R., Toiber, D., Treebak, J.T., Valenzano, D.R., Verdin, E., Vijg, J., Young, S., Zhang, L., Bakula, D., Zhavoronkov, A., and Scheibye-Knudsen, M. (2020). ARDD 2020: from aging mechanisms to interventions. Aging-Us12, 24484-24503. DOI 10.18632/aging.202454.

Eline Slagboom

  • van den Akker EB, Trompet S, Barkey Wolf JJH, Beekman M, Suchiman HED, Deelen J, Asselbergs FW, Boersma E, Cats D, Elders PM, Geleijnse JM, Ikram MA, Kloppenburg M, Mei H, Meulenbelt I, Mooijaart SP, Nelissen RGHH, Netea MG, Penninx BWJH, Slofstra M, Stehouwer CDA, Swertz MA, Teunissen CE, Terwindt GM, 't Hart LM, van den Maagdenberg AMJM, van der Harst P, van der Horst ICC, van der Kallen CJH, van Greevenbroek MMJ, van Spil WE, Wijmenga C, Zhernakova A, Zwinderman AH, Sattar N, Jukema JW, van Duijn CM, Boomsma DI, Reinders MJT, Slagboom PE (2020). Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circ Genom Precis Med. 2020 Oct;13(5):541-547. doi: 10.1161/CIRCGEN.119.002610.
  • Beekman M, Schutte BAM, Akker EBVD, Noordam R, Dibbets-Schneider P, de Geus- Oei LF, Deelen J, Rest OV, Heemst DV, Feskens EJM, Slagboom PE (2020). Lifestyle- Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter. Mol Nutr Food Res. 2020 May;64(10):e1900818. doi: 10.1002/mnfr.201900818. PMID: 32271991; PMCID: PMC7317364.
  • Beenakker KGM, Westendorp RGJ, de Craen AJM, Chen S, Raz Y, Ballieux BEPB, Nelissen RGHH, Later AFL, Huizinga TW, Slagboom PE, Boomsma DI, Maier AB (2020). Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations. J Innate Immun. 2020;12(2):142-153. doi: 10.1159/000499840. PMID: 31230049; PMCID: PMC7098282.
  • Benedetti E, Gerstner N, Pučić-Baković M, Keser T, Reiding KR, Ruhaak LR, Štambuk T, Selman MHJ, Rudan I, Polašek O, Hayward C, Beekman M, Slagboom E, Wuhrer M, Dunlop MG, Lauc G, Krumsiek J (2020). Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference. Metabolites. 2020 Jul 2;10(7). pii: E271. doi: 10.3390/metabo10070271. PMID: 32630764; PMCID: PMC7408386.
  • van den Berg N, Rodríguez-Girondo M, Mandemakers K, Janssens AAPO, Beekman M, Slagboom PE (2020). Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies. Aging Cell. 2020 Jun;19(6):e13139. doi: 10.1111/acel.13139. PMID: 32352215; PMCID: PMC7294789.
  • Bos MM, Noordam R, Bennett K, Beekman M, Mook-Kanamori DO, Willems van Dijk K, Slagboom PE, Lundstedt T, Surowiec I, van Heemst D (2020). Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity. Metabolomics. 2020 Mar 2;16(3):35. doi: 10.1007/s11306-020-01653-7. PMID: 32124065; PMCID: PMC7051926.
  • Bot M, Milaneschi Y, Al-Shehri T, Amin N, Garmaeva S, Onderwater GLJ, Pool R, Thesing CS, Vijfhuizen LS, Vogelzangs N, Arts ICW, Demirkan A, van Duijn C, van Greevenbroek M, van der Kallen CJH, Köhler S, Ligthart L, van den Maagdenberg AMJM, Mook-Kanamori DO, de Mutsert R, Tiemeier H, Schram MT, Stehouwer CDA, Terwindt GM, Willems van Dijk K, Fu J, Zhernakova A, Beekman M, Slagboom PE, Boomsma DI, Penninx BWJH; BBMRI-NL Metabolomics Consortium (2020). Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls. Biol Psychiatry. 2020 Mar 1;87(5):409-418. doi: 10.1016/j.biopsych.2019.08.016. PMID: 31635762.
  • Chen S, Pawelec G, Trompet S, Goldeck D, Mortensen LH, Slagboom PE, Christensen K, Gussekloo J, Kearney P, Buckley BM, Ford I, Jukema JW, Westendorp RGJ, Maier AB (2020). Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. J Infect Dis. 2020 Sep 10:jiaa480. doi: 10.1093/infdis/jiaa480.
  • Giacconi R, Malavolta M, Bürkle A, Moreno-Villanueva M, Franceschi C, Capri M, Slagboom PE, Jansen EHJM, Dollé MET, Grune T, Weber D, Hervonen A, Stuetz W, Breusing N, Ciccarone F, Zampieri M, Aversano V, Caiafa P, Formentini L, Piacenza F, Pierpaoli E, Basso A, Provinciali M, Cardelli M (2020). Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians. Nutrients. 2019 Dec 6;11(12). pii: E2986. doi: 10.3390/nu11122986.
  • Giacconi R, Maggi F, Macera L, Spezia PG, Pistello M, Provinciali M, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Stuetz W, Gonos ES, Schön C, Bernhardt J, Grubeck-Loebenstein B, Sikora E, Dudkowska M, Janiszewska D, Toussaint O, Debacq-Chainiaux F, Franceschi C, Capri M, Hervonen A, Hurme M, Slagboom E, Breusing N, Mocchegiani E, Malavolta M (2020). Prevalence and Loads of Torquetenovirus in the European MARK-AGE Study Population. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1838-1845. doi: 10.1093/gerona/glz293. PMID: 31838498.
  • van der Graaf A, Claringbould A, Rimbert A; BIOS Consortium, Westra HJ, Li Y, Wijmenga C, Sanna S (2020). Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids. Nat Commun. 2020 Oct 1;11(1):4930. doi: 10.1038/s41467-020-18716-x.
  • Hagenbeek FA, Pool R, van Dongen J, Draisma HHM, Jan Hottenga J, Willemsen G, Abdellaoui A, Fedko IO, den Braber A, Visser PJ, de Geus EJCN, Willems van Dijk K, Verhoeven A, Suchiman HE, Beekman M, Slagboom PE, van Duijn CM; BBMRI Metabolomics Consortium, Harms AC, Hankemeier T, Bartels M, Nivard MG, Boomsma DI (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nat Commun. 2020 Jan 7;11(1):39. doi: 10.1038/s41467-019-13770-6. Erratum in: Nat Commun. 2020 Mar 31;11(1):1702. PMID: 31911595; PMCID: PMC6946682.
  • Hammerschlag AR, Byrne EM; eQTLGen Consortium; BIOS Consortium, Bartels M, Wray NR, Middeldorp CM (2020). Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies. Biol Psychiatry. 2020 Sep 15;88(6):470-479. doi: 10.1016/j.biopsych.2020.05.002. PMID: 32684367.
  • Hop PJ, Luijk R, Daxinger L, van Iterson M, Dekkers KF, Jansen R; BIOS Consortium, van Meurs JBJ, 't Hoen PAC, Ikram MA, van Greevenbroek MMJ, Boomsma DI, Slagboom PE, Veldink JH, van Zwet EW, Heijmans BT (2020). Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference. Genome Biol. 2020 Aug 28;21(1):220. doi: 10.1186/s13059-020-02114-z. PMID: 32859263; PMCID: PMC7453518.
  • Klarić L, Tsepilov YA, Stanton CM, Mangino M, Sikka TT, Esko T, Pakhomov E, Salo P, Deelen J, McGurnaghan SJ, Keser T, Vučković F, Ugrina I, Krištić J, Gudelj I, Štambuk J, Plomp R, Pučić-Baković M, Pavić T, Vilaj M, Trbojević- Akmačić I, Drake C, Dobrinić P, Mlinarec J, Jelušić B, Richmond A, Timofeeva M, Grishchenko AK, Dmitrieva J, Bermingham ML, Sharapov SZ, Farrington SM, Theodoratou E, Uh HW, Beekman M, Slagboom EP, Louis E, Georges M, Wuhrer M, Colhoun HM, Dunlop MG, Perola M, Fischer K, Polasek O, Campbell H, Rudan I, Wilson JF, Zoldoš V, Vitart V, Spector T, Aulchenko YS, Lauc G, Hayward C (2020). Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Sci Adv. 2020 Feb 19;6(8):eaax0301. doi: 10.1126/sciadv.aax0301. PMID: 32128391; PMCID: PMC7030929.
  • Knol MJ, Lu D, Traylor M, Adams HHH, Romero JRJ, Smith AV, Fornage M, Hofer E, Liu J, Hostettler IC, Luciano M, Trompet S, Giese AK, Hilal S, van den Akker EB, Vojinovic D, Li S, Sigurdsson S, van der Lee SJ, Jack CR Jr, Wilson D, Yilmaz P, Satizabal CL, Liewald DCM, van der Grond J, Chen C, Saba Y, van der Lugt A, Bastin ME, Windham BG, Cheng CY, Pirpamer L, Kantarci K, Himali JJ, Yang Q, Morris Z, Beiser AS, Tozer DJ, Vernooij MW, Amin N, Beekman M, Koh JY, Stott DJ, Houlden H, Schmidt R, Gottesman RF, MacKinnon AD, DeCarli C, Gudnason V, Deary IJ, van Duijn CM, Slagboom PE, Wong TY, Rost NS, Jukema JW, Mosley TH, Werring DJ, Schmidt H, Wardlaw JM, Ikram MA, Seshadri S, Launer LJ, Markus HS; Alzheimer's Disease Neuroimaging Initiative (2020). Association of common genetic variants with brain microbleeds: A genome-wide association study. Neurology. 2020 Dec 15;95(24):e3331-e3343. doi: 10.1212/WNL.0000000000010852. PMID: 32913026; PMCID: PMC7836652.
  • Van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto- Temporal Dementia); Netherlands Brain Bank (NBB), Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff- Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D; GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H (2020). Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathol. 2020 May;139(5):959-962. doi: 10.1007/s00401-019-02107-8. Erratum for: Acta Neuropathol. 2019 Aug;138(2):237-250. PMID: 31955222; PMCID: PMC7181435.
  • Li C, Stoma S, Lotta LA, Warner S, Albrecht E, Allione A, Arp PP, Broer L, Buxton JL, Da Silva Couto Alves A, Deelen J, Fedko IO, Gordon SD, Jiang T, Karlsson R, Kerrison N, Loe TK, Mangino M, Milaneschi Y, Miraglio B, Pervjakova N, Russo A, Surakka I, van der Spek A, Verhoeven JE, Amin N, Beekman M, Blakemore AI, Canzian F, Hamby SE, Hottenga JJ, Jones PD, Jousilahti P, Mägi R, Medland SE, Montgomery GW, Nyholt DR, Perola M, Pietiläinen KH, Salomaa V, Sillanpää E, Suchiman HE, van Heemst D, Willemsen G, Agudo A, Boeing H, Boomsma DI, Chirlaque MD, Fagherazzi G, Ferrari P, Franks P, Gieger C, Eriksson JG, Gunter M, Hägg S, Hovatta I, Imaz L, Kaprio J, Kaaks R, Key T, Krogh V, Martin NG, Melander O, Metspalu A, Moreno C, Onland-Moret NC, Nilsson P, Ong KK, Overvad K, Palli D, Panico S, Pedersen NL, Penninx BWJH, Quirós JR, Jarvelin MR, Rodríguez-Barranco M, Scott RA, Severi G, Slagboom PE, Spector TD, Tjonneland A, Trichopoulou A, Tumino R, Uitterlinden AG, van der Schouw YT, van Duijn CM, Weiderpass E, Denchi EL, Matullo G, Butterworth AS, Danesh J, Samani NJ, Wareham NJ, Nelson CP, Langenberg C, Codd V (2020). Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet. 2020 Mar 5;106(3):389-404. doi: 10.1016/j.ajhg.2020.02.006. PMID: 32109421; PMCID: PMC7058826.
  • Liu J, Lahousse L, Nivard MG, Bot M, Chen L, van Klinken JB, Thesing CS, Beekman M, van den Akker EB, Slieker RC, Waterham E, van der Kallen CJH, de Boer I, Li-Gao R, Vojinovic D, Amin N, Radjabzadeh D, Kraaij R, Alferink LJM, Murad SD, Uitterlinden AG, Willemsen G, Pool R, Milaneschi Y, van Heemst D, Suchiman HED, Rutters F, Elders PJM, Beulens JWJ, van der Heijden AAWA, van Greevenbroek MMJ, Arts ICW, Onderwater GLJ, van den Maagdenberg AMJM, Mook-Kanamori DO, Hankemeier T, Terwindt GM, Stehouwer CDA, Geleijnse JM, 't Hart LM, Slagboom PE, van Dijk KW, Zhernakova A, Fu J, Penninx BWJH, Boomsma DI, Demirkan A, Stricker BHC, van Duijn CM (2020). Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas. Nat Med. 2020 Jan;26(1):110-117. doi: 10.1038/s41591-019-0722-x. PMID: 31932804.
  • Maas SCE, Vidaki A, Wilson R, Teumer A, Liu F, van Meurs JBJ, Uitterlinden AG, Boomsma DI, de Geus EJC, Willemsen G, van Dongen J, van der Kallen CJH, Slagboom PE, Beekman M, van Heemst D, van den Berg LH; BIOS Consortium, Duijts L, Jaddoe VWV, Ladwig KH, Kunze S, Peters A, Ikram MA, Grabe HJ, Felix JF, Waldenberger M, Franco OH, Ghanbari M, Kayser M (2020). Validated inference of smoking habits from blood with a finite DNA methylation marker set. Eur J Epidemiol. 2019 Nov;34(11):1055-1074. doi: 10.1007/s10654-019-00555-w. PMID: 31494793; PMCID: PMC6861351.
  • Mandaviya PR, Joehanes R, Brody J, Castillo-Fernandez JE, Dekkers KF, Do AN, Graff M, Hänninen IK, Tanaka T, de Jonge EAL, Kiefte-de Jong JC, Absher DM, Aslibekyan S, de Rijke YB, Fornage M, Hernandez DG, Hurme MA, Ikram MA, Jacques PF, Justice AE, Kiel DP, Lemaitre RN, Mendelson MM, Mikkilä V, Moore AZ, Pallister T, Raitakari OT, Schalkwijk CG, Sha J, Slagboom EPE, Smith CE, Stehouwer CDA, Tsai PC, Uitterlinden AG, van der Kallen CJH, van Heemst D, Arnett DK, Bandinelli S, Bell JT, Heijmans BT, Lehtimäki T, Levy D, North KE, Sotoodehnia N, van Greevenbroek MMJ, van Meurs JBJ, Heil SG (2020). Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals. Am J Clin Nutr. 2019 Aug 1;110(2):437-450. doi: 10.1093/ajcn/nqz031.
  • Meessen JMTA, Fiocco M, Tordoir RL, Sjer A, Verdegaal SHM, Slagboom PE, Vliet Vlieland TPM, Nelissen RGHH (2020). Association of handgrip strength with patient-reported outcome measures after total hip and knee arthroplasty. Rheumatol Int. 2020 Apr;40(4):565-571. doi: 10.1007/s00296-020-04532-5. PMID: 32072233.
  • Meessen JMTA, Saberi-Hosnijeh F, Bomer N, den Hollander W, van der Bom JG, van Hilten JA, van Spil WE, So-Osman C, Uitterlinden AG, Kloppenburg M, Nelissen RGHH, van Duijn CM, Slagboom PE, van Meurs JBJ, Meulenbelt I (2020). Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI. Sci Rep. 2020 Sep 22;10(1):15459. doi: 10.1038/s41598-020-71811-3. PMID: 32963331; PMCID: PMC7508826.
  • Ouwens KG, Jansen R, Nivard MG, van Dongen J, Frieser MJ, Hottenga JJ, Arindrarto W, Claringbould A, van Iterson M, Mei H, Franke L, Heijmans BT, A C 't Hoen P, van Meurs J, Brooks AI; BIOS Consortium, Penninx BWJH, Boomsma DI (2020). A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. Eur J Hum Genet. 2020 Feb;28(2):253-263. doi: 10.1038/s41431-019-0511-5. PMID: 31558840; PMCID: PMC6974598.
  • Pelsma ICM, Claessen KMJA, Slagboom PE, van Heemst D, Pereira AM, Kroon HM, Ramos YFM, Kloppenburg M, Biermasz NR, Meulenbelt IM (2020). Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis. Eur J Endocrinol. 2021 Jan;184(1):29-39. doi: 10.1530/EJE-20-0904. PMID: 33112260.
  • Pool R, Hagenbeek FA, Hendriks AM, van Dongen J, Willemsen G, de Geus E; BBMRI Metabolomics Consortium, Willems van Dijk K, Verhoeven A, Suchiman HE, Beekman M, Slagboom PE, Harms AC, Hankemeier T, Boomsma DI (2020). Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data. Twin Res Hum Genet. 2020 Jun;23(3):145-155. doi: 10.1017/thg.2020.53. PMID: 32635965.
  • van der Poort EKJ, Gunn DA, Beekman M, Griffiths CEM, Slagboom PE, van Heemst D, Noordam R (2020). Basal cell carcinoma genetic susceptibility increases the rate of skin ageing: a Mendelian randomization study. J Eur Acad Dermatol Venereol. 2020 Jan;34(1):97-100. doi: 10.1111/jdv.15880. PMID: 31419349.
  • Raz Y, van den Akker EB, Roest T, Riaz M, van de Rest O, Suchiman HED, Lakenberg N, Stassen SA, van Putten M, Feskens EJM, Reinders MJT, Goeman J, Beekman M, Raz V, Slagboom PE (2020). A data-driven methodology reveals novel myofiber clusters in older human muscles. FASEB J. 2020 Apr;34(4):5525-5537. doi: 10.1096/fj.201902350R. PMID: 32141137.
  • Rutten JW, Hack RJ, Duering M, Gravesteijn G, Dauwerse JG, Overzier M, van den Akker EB, Slagboom E, Holstege H, Nho K, Saykin A, Dichgans M, Malik R, Lesnik Oberstein SAJ (2020). Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank: CADASIL to nonpenetrance. Neurology. 2020 Sep 29;95(13):e1835-e1843. doi: 10.1212/WNL.0000000000010525. Epub 2020 Jul 30. PMID: 32732295; PMCID: PMC7682826.
  • Salgado C, Gruis N; BIOS Consortium, Heijmans BT, Oosting J, van Doorn R (2020). Genome-wide analysis of constitutional DNA methylation in familial melanoma. Clin Epigenetics. 2020 Mar 6;12(1):43. doi: 10.1186/s13148-020-00831-7. PMID: 32143689; PMCID: PMC7060565.
  • Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, Kumar RB, van den Akker EB, McWhirter RE, Trompet S, Mishra A, Saba Y, Satizabal CL, Beaudet G, Petit L, Tsuchida A, Zago L, Schilling S, Sigurdsson S, Gottesman RF, Lewis CE, Aggarwal NT, Lopez OL, Smith JA, Valdés Hernández MC, van der Grond J, Wright MJ, Knol MJ, Dörr M, Thomson RJ, Bordes C, Le Grand Q, Duperron MG, Smith AV, Knopman DS, Schreiner PJ, Evans DA, Rotter JI, Beiser AS, Maniega SM, Beekman M, Trollor J, Stott DJ, Vernooij MW, Wittfeld K, Niessen WJ, Soumaré A, Boerwinkle E, Sidney S, Turner ST, Davies G, Thalamuthu A, Völker U, van Buchem MA, Bryan RN, Dupuis J, Bastin ME, Ames D, Teumer A, Amouyel P, Kwok JB, Bülow R, Deary IJ, Schofield PR, Brodaty H, Jiang J, Tabara Y, Setoh K, Miyamoto S, Yoshida K, Nagata M, Kamatani Y, Matsuda F, Psaty BM, Bennett DA, De Jager PL, Mosley TH, Sachdev PS, Schmidt R, Warren HR, Evangelou E, Trégouët DA; International Network against Thrombosis (INVENT) Consortium; International Headache Genomics Consortium (IHGC), Ikram MA, Wen W, DeCarli C, Srikanth VK, Jukema JW, Slagboom EP, Kardia SLR, Okada Y, Mazoyer B, Wardlaw JM, Nyquist PA, Mather KA, Grabe HJ, Schmidt H, Van Duijn CM, Gudnason V, Longstreth WT Jr, Launer LJ, Lathrop M, Seshadri S, Tzourio C, Adams HH, Matthews PM, Fornage M, Debette S (2020). Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun. 2020 Dec 8;11(1):6285. doi: 10.1038/s41467-020-19111-2. PMID: 33293549; PMCID: PMC7722866.
  • van der Sijp MPL, Suchiman HED, Eijk M, Vojinovic D, Niggebrugge AHP, Blauw GJ, Achterberg WP, Slagboom PE (2020). The Prognostic Value of Metabolic Profiling in Older Patients With a Proximal Femoral Fracture. Geriatr Orthop Surg Rehabil. 2020 Oct 29;11:2151459320960091. doi: 10.1177/2151459320960091. PMID: 33194255; PMCID: PMC7607756.
  • van der Spoel E, Roelfsema F, Akintola AA, Jansen SW, Slagboom PE, Westendorp RGJ, Blauw GJ, Pijl H, van Heemst D (2020). Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects. J Clin Endocrinol Metab. 2020 Apr 1;105(4):e1201–14. doi: 10.1210/clinem/dgz253. PMID: 31853555; PMCID: PMC7065845.
  • Tilburg J, Slieker RC, Suchiman HED, Heath A, Heemst DV, Slagboom PE, de Gruijl FR, Gunn DA, Heijmans BT (2020). Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response. Epigenomics. 2020 Apr;12(7):563-573. doi: 10.2217/epi-2019-0251. PMID: 32516006.

Philipp Steven

  • Osae EA, Ablordeppey RK, Horstmann J, Kumah DB, Steven P (2020). Clinical Dry Eye and Meibomian Gland Features Among Dry Eye Patients in Rural and Urban Ghana. Clin Ophthalmol. 2020;14:4055-4063. doi: 10.2147/OPTH.S275584. eCollection 2020. PubMed PMID: 33262570; PubMed Central PMCID: PMC7699986.
  • Osae EA, Bullock T, Chintapalati M, Brodesser S, Hanlon S, Redfern R, Steven P, Smith CW, Rumbaut RE, Burns AR. Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production.Int J Mol Sci. 2020 Nov 20;21(22). doi: 10.3390/ijms21228772. PubMed PMID: 33233559; PubMed Central PMCID: PMC7699756. 
  • Steven P, Schwab S, Kiesewetter A, Saban DR, Stern ME, Gehlsen U. Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy.Int J Mol Sci. 2020 Oct 12;21(20).doi: 10.3390/ijms21207514. PubMed PMID: 33053795; PubMed Central PMCID: PMC7589149.
  • Steven P, Faust C, Holtick U, Scheid C, Tahmaz V, Stern ME, Gehlsen U. Adverse environmental conditions are a risk factor for ocular GvHD after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2020 Sep;55(9):1851-1853. doi: 10.1038/s41409-020-0824-6. Epub 2020 Feb 10. PubMed PMID: 32042103.
  • Eberwein, P., Krösser, S., and Steven, P. (2020). Semifluorinated Alkane Eye Drops in Chronic Ocular Graft-versus-Host Disease: A Prospective, Multicenter, Noninterventional Study. Ophthalmic Res63, 50-58. 10.1159/000499158.
  • Faust, C., Dietrich-Ntoukas, T., and Steven, P. (2020). Second Survey on Patient-centred Care of Ocular Graft-versus-Host Disease in Germany. Klin Monatsbl Augenh237, 1353-1357. 10.1055/a-0854-3984.
  • Osae, E., Chintalapati, M., Bullock, T., Brodesser, S., Steven, P., Smith, C.W., Rumbaut, R., and Burns, A.R. (2020). Obese mice show dyslipidemia and a changed meibum profile. Invest Ophth Vis Sci61.

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Achim Tresch

  • Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M (2020). FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity. 2020 Jun 16;52(6):978-993.e6. doi: 10.1016/j.immuni.2020.04.002. Epub 2020 May 1

Marc Tittgemeyer

  • Kostić D, Hilgetag CC, Tittgemeyer M (2020). Unifying the essential concepts of biological networks: biological insights and philosophical foundations. Philos Trans R Soc Lond B Biol Sci. 2020 Apr 13;375(1796):20190314. doi: 10.1098/rstb.2019.0314. Epub 2020 Feb 24. PMID: 32089117
  • Alicart H, Obst M, Heldmann M, Göttlich M, Tittgemeyer M, Münte T (2020). Modulation of visual processing of food by transcutaneous vagus nerve stimulation (tVNS). Brain Imaging Behav. 2020 Sep 14. doi: 10.1007/s11682-020-00382-8. Online ahead of print
  • Cole D, Diaconescu A, Pfeiffer U, Brodersen K, Mathys C, Julkowski D, Ruhrmann S, Schilbach L, Tittgemeyer M, Vogeley K, Stephan K (2020). Atypical processing of uncertainty in individuals at risk for psychosis. Neuroimage Clin. 2020;26:102239. doi: 10.1016/j.nicl.2020.102239. Epub 2020 Mar 7 
  • Edwin Thanarajah S, Tittgemeyer M (2020). Food reward and gut-brain signaling. Neuroforum. 26(1), 1-9
  • Hanssen R, Kohlenbach L, Albus K, Thanarajah S, Cornely O, Tittgemeyer M, Faust M (2020). Erfolgreiche Lebensstiländerung für schwer adipöse Patienten – Eine kontrollierte Studie zur Evaluation eines Patientenschulungsprogramms. Diabetologie und Stoffwechsel. 5: 157-164 
  • Obst MA, Heldmann M, Alicart H, Tittgemeyer M, Münte  TF (2020). Effect of short-term transcutaneous vagus nerve stimulation (tVNS) on brain processing of foodcues: An electrophysiological study. Front Hum Neurosci. 2020 Jun 18;14:206. doi: 10.3389/fnhum.2020.00206. eCollection 2020 
  • Mosley PE, Paliwal S, Robinson K, Coyne T, Silburn P, Tittgemeyer M, Stephan KE, Perry A, Breakspear M (2020). The Structural Connectivity of Subthalamic Deep Brain Stimulation Correlates with Impulsivity in Parkinson’s. Brain. 2020 Jul 1;143(7):2235-2254.  doi: 10.1093/brain/awaa148 
  • Pelzer E, Pauls K, Braun N, Tittgemeyer M, Timmermann L (2020). Probabilistic tractography in the ventrolateral thalamic nucleus: cerebellar and pallidal connections. Brain Struct Funct. 2020; 225(5): 1685–1689. Published online 2020 May 3. doi: 10.1007/s00429-020-02076-9 
  • Ruppert MC, Greuel A, Tahmasian M, Schwartz F, Stürmer S, Maier F, Hammes J, Tittgemeyer M, Timmermann L, van Eimeren T, Drzegza A, Eggers C (2020). Network degeneration in Parkinson’s: Multimodal imaging of nigro-striato- cortical dysfunction, Brain. 2020 Mar 1;143(3):944-959. doi: 10.1093/brain/awaa019
  • Greuel, A., Trezzi, J.P., Glaab, E., Ruppert, M.C., Maier, F., Jäger, C., Hodak, Z., Lohmann, K., Ma, Y.L., Eidelberg, D., Timmermann, L., Hiller, K., Tittgemeyer, M., Drzezga, A., Diederich, N., and Eggers, C. (2020). Variants in Parkinson's Disease: Clinical, Metabolomic, and Multimodal Neuroimaging Phenotypes. Movement Disord35, 2201-2210. 10.1002/mds.28225.
  • Pelzer, E.A., Dillenburger, B., Grundmann, S., Iliaev, V., Aschenberg, S., Melzer, C., Hess, M., Fink, G.R., Eggers, C., Tittgemeyer, M., and Timmermann, L. (2020). Hypomania and saccadic changes in Parkinson's disease: influence of D2 and D3 dopaminergic signalling. Npj Parkinsons Dis6. ARTN 5. 10.1038/s41531-019-0107-3.
  • Sevgi, M., Diaconescu, A.O., Henco, L., Tittgemeyer, M., and Schilbach, L. (2020). Social Bayes: Using Bayesian Modeling to Study Autistic Trait-Related Differences in Social Cognition. Biol Psychiat87, 185-193. 10.1016/j.biopsych.2019.09.032.

Aleksandra Trifunovic

  • Ricke KM, Paß T, Kimoloi S, Fährmann K, Jüngst C, Schauss A, Baris OR, Aradjanski M, Trifunovic A, Eriksson Faelker TM, Bergami M, Wiesner RJ (2020). Mitochondrial dysfunction combined with high calcium load leads to impaired antioxidant defense underlying the selective loss of nigral dopaminergic neurons. J Neurosci. 2020 Jan 29. pii: 1345-19. doi: 10.1523/JNEUROSCI.1345-19.2019. [Epub ahead of print] PMID:32005765 
  • Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A (2020). A salvage pathway maintains highly functional respiratory complex I. Nat Commun. 2020 Apr 2;11(1):1643. doi: 10.1038/s41467-020-15467-7 
  • Nemeth CL, Tomlinson SN, Rosen M, O'Brien BM, Larraza O, Jain M, Murray CF, Marx JS, Delannoy M, Fine AS, Wu D, Trifunovic A, Fatemi A (2020). Neuronal ablation of mt-AspRS in mice induces immune pathway activation prior to severe and progressive cortical and behavioral disruption. Exp Neurol. 2020 Apr;326:113164. doi: 10.1016/j.expneurol.2019.113164. Epub 2019 Dec 27. PMID:31887305 
  • Shytaj IL, Lucic B, Forcato M, Penzo C, Billingsley J, Laketa V, Bosinger S, Stanic M, Gregoretti F, Antonelli L, Oliva G, Frese CK, Trifunovic A, Galy B, Eibl C, Silvestri G, Bicciato S, Savarino A, Lusic M (2020). Alterations of redox and iron metabolism accompany the development of HIV latency. EMBO J. 2020 May 4;39(9):e102209. doi: 10.15252/embj.2019102209. Epub 2020 Mar 11. PMID:32157726; PMCID: PMC7196916 
  • Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC (2020). GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab. 2020 Jun 2;31(6):1189-1205.e13. doi: 10.1016/j.cmet.2020.05.001. Epub 2020 May 19. PMID:32433922; PMCID: PMC7272126  
  • Hofsetz E, Demir F, Szczepanowska K, Kukat A, Kizhakkedathu JN, Trifunovic A, Huesgen PF (2020). The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis. Mol Cell Proteomics. 2020 Aug;19(8):1330-1345. doi:10.1074/mcp.RA120.002082. Epub 2020 May 28. PMID: 32467259 
  • Lopes AFC, Bozek K, Herholz M, Trifunovic A, Rieckher M, Schumacher B (2020). A C. elegans model for neurodegeneration in Cockayne syndrome. Nucleic Acids Res. 2020 Oct 6:gkaa795. doi: 10.1093/nar/gkaa795. Online ahead of print. PMID: 33021672 
  • Meul T, Berschneider K, Schmitt S, Mayr CH, Mattner LF, Schiller HB, Yazgili AS, Wang X, Lukas C, Schlesser C, Prehn C, Adamski J, Graf E, Schwarzmayr T, Perocchi F, Kukat A, Trifunovic A, Kremer L, Prokisch H, Popper B, von Toerne C, Hauck SM, Zischka H, Meiners S (2020). Mitochondrial Regulation of the 26S Proteasome. Cell Rep. 2020 Aug 25;32(8):108059. PMID: 32846138   
  • Rumyantseva A, Motori E, Trifunovic A (2020). DARS2 is indispensable for Purkinje cell survival and protects against cerebellar ataxia. Hum Mol Genet. 2020 Oct 10;29(17):2845-2854. PMID: 32766765  

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Mirka Uhlirova

  • Csordás G, Grawe F, Uhlirova M (2020). Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments.Elife. 2020 Oct 7;9:e57297. doi: 10.7554/eLife.57297.PMID: 33026342  
  • Stanković D, Claudius AK, Schertel T, Bresser T, Uhlirova M (2020). A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8. Dis Model Mech. 2020 Jun 26;13(6):dmm043174. doi: 10.1242/dmm.043174

Dario Valenzano

  • Khallaf MA, Cui R, Weissflog J, Svatoš A, Dweck HKM, Valenzano DR, Hansson BS, Knaden M (2020). Large-scale characterization of sex pheromone communication systems in Drosophila. bioRxiv. 2020.09.21.305854; doi: doi.org/10.1101/2020.09.21.305854   
  • Willemsen D, Cui R, Reichard M, Valenzano DR (2020). Intra-species differences in population size shape life history and genome evolution. Elife. 2020 Sep 1;9:e55794. doi: 10.7554/eLife.55794  
  • Bradshaw WJ, Poeschla M, Placzek A, Valenzano DR (2020). Antibody repertoire sequencing reveals systemic and mucosal immunosenescence in the short-lived turquoise killifish. bioRxiv. 2020.08.21.261248; doi: doi.org/10.1101/2020.08.21.261248
  • Popkes M, Valenzano DR (2020). Microbiota–host interactions shape ageing dynamics. Philos Trans R Soc Lond B Biol Sci. 2020 Sep 28;375(1808):20190596. doi: 10.1098/rstb.2019.0596. Epub 2020 Aug 10 
  • Cui R, Tyers AM, Malubhoy ZJ, Wisotsky S, Valdesalici S, Henriette E, Kosakovsky Pond SL, Valenzano DR (2020). Genomics of a killifish from the Seychelles islands supports transoceanic island colonization and reveals relaxed selection of developmental genes. bioRxiv.doi.org/10.1101/2020.08.03.232421 
  • Cui R, Willemsen D, Valenzano DR (2020). Nothobranchius furzeri (African Turquoise Killifish). Trends Genet.doi.org/10.1016/j.tig.2020.01.012 
  • Bradshaw WJ, Valenzano DR (2020). Extreme genomic volatility characterises the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes. Proc Biol Sci. 2020 May 27;287(1927):20200489. doi: 10.1098/rspb.2020.0489. Epub 2020 May 13
  • Poeschla M, Valenzano DR (2020). The turquoise killifish: a genetically tractable model for the study of aging. J Exp Biol. 2020 Feb 7;223(Pt Suppl 1):jeb209296. doi: 10.1242/jeb.209296
  • Mkrtchyan, G.V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., de Cabo, R., Campisi, J., Cuervo, A.M., Demaria, M., Ewald, C.Y., Fang, E.F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C.G., Georgievskaya, A., Gladyshev, V.N., Glass, D.J., Gorbunova, V., de Grey, A., He, W.W., Hoeijmakers, J., Hoffmann, E., Horvath, S., Houtkooper, R.H., Jensen, M.K., Jensen, M.B., Kane, A., Kassem, M., de Keizer, P., Kennedy, B., Karsenty, G., Lamming, D.W., Lee, K.F., MacAulay, N., Mamoshina, P., Mellon, J., Molenaars, M., Moskalev, A., Mund, A., Niedernhofer, L., Osborne, B., Pak, H.H., Parkhitko, A., Raimundo, N., Rando, T.A., Rasmussen, L.J., Reis, C., Riedel, C.G., Franco-Romero, A., Schumacher, B., Sinclair, D.A., Suh, Y., Taub, P.R., Toiber, D., Treebak, J.T., Valenzano, D.R., Verdin, E., Vijg, J., Young, S., Zhang, L., Bakula, D., Zhavoronkov, A., and Scheibye-Knudsen, M. (2020). ARDD 2020: from aging mechanisms to interventions. Aging-Us12, 24484-24503. DOI 10.18632/aging.202454.

David Vilchez

  • Llamas E, Alirzayeva H, Loureiro R, Vilchez  D (2020). The intrinsic proteostasis network of stem cells. Curr Opin Cell Biol. 2020 Dec;67:46-55. doi: 10.1016/j.ceb.2020.08.005. Epub 2020 Sep 2 
  • Fatima A, Irmak D, Noormohammadi A, Rinschen MM, Das A, Leidecker O, Schindler C, Sánchez-Gaya V, Wagle P, Pokrzywa W, Hoppe T, Rada-Iglesias A, Vilchez D (2020). The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Commun Biol. 3,262 (2020). doi.org/10.1038/s42003-020-0984-3 
  • Thiruvalluvan A, de Mattos EP, Brunsting JF, Bakels R, Serlidaki D, Barazzuol L, Conforti P, Fatima A, Koyuncu S, Cattaneo E, Vilchez D, Bergink S, Boddeke EHWG, Copray S, Kampinga HH (2020). DNAJB6, a key factor in neuronal sensitivity to amyloidogenesis. Mol Cell. 2020 Apr 16;78(2):346-358.e9. doi: 10.1016/j.molcel.2020.02.022. Epub 2020 Apr 7
  • Fatima, A., Irmak, D., Noormohammadi, A., Rinschen, M.M., Das, A., Leidecker, O., Schindler, C., Sánchez-Gaya, V., Wagle, P., Pokrzywa, W., Hoppe, T., Rada-Iglesias, A., and Vilchez, D. (2020). The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Communications Biology3. ARTN 262. 10.1038/s42003-020-0984-3.
  • Koyuncu, S., Saez, I., Lee, H.J., Gutierrez-Garcia, R., Pokrzywa, W., Fatima, A., Hoppe, T., and Vilchez, D. (2020). Author Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat Commun11, 985. 10.1038/s41467-020-14726-x.
  • Musio, B., Ragone, R., Todisco, S., Rizzuti, A., Latronico, M., Mastrorilli, P., Pontrelli, S., Intini, N., Scapicchio, P., Triggiani, M., Di Noia, T., Acquotti, D., Airoldi, C., Assfalg, M., Barge, A., Bateman, L., Benevelli, F., Bertelli, D., Bertocchi, F., Bieliauskas, A., Borioni, A., Caligiani, A., Callone, E., Camra, A., Marincola, F.C., Chalasani, D., Consonni, R., Dambruoso, P., Davalli, S., David, T., Diehl, B., Donarski, J., Gil, A.M., Gobetto, R., Goldoni, L., Hamon, E., Harwood, J.S., Kobrlová, A., Longobardi, F., Luisi, R., Mallamace, D., Mammi, S., Martin-Biran, M., Mazzei, P., Meie, A., Milone, S., Vilchez, D.M., Mulder, R.J., Napoli, C., Ragno, D., Randazzo, A., Rossi, M.C., Rotondo, A., Sackus, A., Barajas, E.S., Schievano, E., Sitaram, B., Stevanato, L., Takis, P.G., Teipel, J., Thomas, F., Torregiani, E., Valensin, D., Veronesi, M., Warren, J., Wist, J., Zailer-Hafer, E., Zuccaccia, C., and Gallo, V. (2020). A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy. Talanta214. ARTN 120855. 10.1016/j.talanta.2020.120855.
  • Saez, I., Gerbracht, J.V., Koyuncu, S., Lee, H.J., Horn, M., Kroef, V., Denzel, M.S., Dieterich, C., Gehring, N.H., and Vilchez, D. (2020). The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. Febs Lett594, 175-188. 10.1002/1873-3468.13559.

Silvia von Karstedt

  • Bebber CM, Müller F, Prieto Clemente L, Weber J, von Karstedt S (2020). Ferroptosis in Cancer Cell Biology. Cancers (Basel). 2020 Jan 9;12(1):164. doi: 10.3390/cancers12010164.PMID: 31936571
  • Clemente LP, Rabenau M, Tang S, Stanka J, Cors E, Stroh J, Culmsee C, Karstedt von S (2020). Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells. 2020 Oct 9;9(10):2259. doi: 10.3390/cells9102259 
  • Allgöwer C, Kretz AL, von Karstedt S, Wittau M, Henne-Bruns D, Lemke J (2020). Friend or Foe: S100 Proteins in Cancer. Cancers (Basel). 2020 Jul 24;12(8):2037. doi: 10.3390/cancers12082037

Johannes Vogt

  • Fischer C, Endle H, Schumann L, Wilken-Schmitz A, Kaiser J, Vogt J*, Tegeder I* (equal contributed last authors) (2020). Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2. Cell Mol Life Sci. 2020 May 28. doi: 10.1007/s00018-020-03553-4

Henning Walczak

  • Müller I, Strozyk E, Schindler S, Beissert S, Oo HZ, Sauter T, Lucarelli P, Raeth S, Hausser A, Al Nakouzi N, Fazli L, Gleave ME, Liu H, Simon HU, Walczak H, Green DR, Bartek J, Daugaard M, Kulms D (2020). Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. Mol Cell. 77(5):970-984, Epub 2020  
  • Annibaldi A, Walczak H (2020). Death Receptors and Their Ligands in Inflammatory Disease and Cancer. Cold Spring Harb Perspect Biol. 2020 Sep 1;12(9):a036384. doi: 10.1101/cshperspect.a036384.
  • von Karstedt S, Walczak H (2020). An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer. Cell Death Dis. 6:14, 2020 
  • Litchfield K, Stanislaw S, Spain L, Gallegos LL, Rowan A, Schnidrig D, Rosenbaum H, Harle A, Au L, Hill SM, Tippu Z, Thomas J, Thompson L, Xu H, Horswell S, Barhoumi A, Jones C, Leith KF, Burgess DL, Watkins TBK, Lim E, Birkbak NJ, Lamy P, Nordentoft I, Dyrskjot L, Pickering L, Hazell S, Jamal-Hanjani M, PEACE Consortium; Larkin J, Swanton C, Alexander NR, Turajlic (2020). Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue. Cell Rep. 2020 May 5;31(5):107550.  doi: 10.1016/j.celrep.2020.107550.

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Sara Wickström

  • Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA (2020). Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020 Apr 9. pii: S0092-8674(20)30345-7. doi: 10.1016/j.cell.2020.03.052 . [Epub ahead of print] 
  • Kim CS, Ding X, Allmeroth K, Biggs, LC, Kolenc OI, L’Hoest N, Chacón-Martínez CA, Edlich-Muth C, Giavalisco P, Quinn KP, Denzel M, EmingSA, Wickström SA (2020). Cell Metab. 2020 Oct 6;32(4):629-642.e8. doi: 10.1016/j.cmet.2020.08.011. Epub 2020 Sep 8 
  • Dekoninck C, Hannezo E, Sifrim A, Malfait M, Miroshnikova YA, Aragona M, Gargouri, S, de Neunheuser C, Dubois C, Voet T, Wickström SA, Simons B, Blanpain C (2020). Defining the design principles of skin epidermis postnatal growth. Cell. 2020 Apr 30;181(3):604-620.e22. doi: 10.1016/j.cell.2020.03.015. Epub 2020 Apr 6 
  • Punovuori K, Wickström SA (2020). How cancer invasion takes shape. Nature. 2020 Sep;585(7825):355-356. doi: 10.1038/d41586-020-02490-3
  • Biggs, L.C., Kim, C.S., Miroshnikova, Y.A., and Wickström, S.A. (2020). Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function. J Invest Dermatol140, 284-290. 10.1016/j.jid.2019.06.137.
  • Ding, X.L., Willenborg, S., Bloch, W., Wickström, S.A., Wagle, P., Brodesser, S., Roers, A., Jais, A., Brüning, J.C., Hall, M.N., Rüegg, M.A., and Eming, S.A. (2020). Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immun145, 283-+. 10.1016/j.jaci.2019.07.033.

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Rudolf J. Wiesner

  • Ricke KM, Paß T, Kimoloi S, Fährmann K, Jüngst C, Schauss A, Baris OR, Aradjanski M, Trifunovic A, Eriksson Faelker TM, Bergami M, Wiesner RJ (2020). Mitochondrial dysfunction combined with high calcium load leads to impaired antioxidant defense underlying the selective loss of nigral dopaminergic neurons. J Neurosci. 31 January 2020,  1345-19; DOI: doi.org/10.1523/JNEUROSCI.1345-19.2019 
  • Basu S, Xie X, Uhler JP, Hedberg-Oldfors C, Milenkovic D, Baris OR, Kimoloi S, Matic S, Stewart JB, Larsson NG, Wiesner RJ, Oldfors A, Gustafsson CM, Falkenberg M, Larsson E (2020). Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing. PLoS Genet. 2020 Dec 14;16(12):e1009242. doi: 10.1371/journal.pgen.1009242. Online ahead of print. PMID: 33315859 
  • Imhof T, Rosenblatt K, Pryymachuk G, Weiland D, Noetzel N, Deschner J, Baris OR, Kimoloi S, Koch M, Wiesner RJ, Korkmaz Y (2020). Epithelial loss of mitochondrial oxidative phosphorylation leads to disturbed enamel and impaired dentin matrix formation in postnatal developed mouse incisor. Sci Rep. 2020 Dec 16;10(1):22037. doi: 10.1038/s41598-020-77954-7. PMID: 33328493  
  • Oexner R, Pla-Martin D, Paß T, Wiesen MHJ, Zentis P, Schauss A, Baris OR, Kimoloi S, Wiesner RJ (2020). Extraocular muscle reveals selective vulnerability of Type IIB fibers to respiratory chain defects induced by mitochondrial DNA alterations. Invest Ophthalmol Vis Sci. 2020 Oct; 61(12): 14. Published online 2020 Oct 15. doi: 10.1167/iovs.61.12.14 
  • Paß TM, Aßfalg M, Tolve S, Blaess M, Rothermel, Wiesner RJ, Ricke KM (2020). The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection. Mol Neurobiol. 2020 Sep;57(9):3646-3657.  doi: 10.1007/s12035-020-01947-w. Epub 2020 Jun 20 
  • Haumann S, Boix J, Knuever J, Bieling A, Vila Sanjurjo A, Elson JL, Blakely EL, Taylor RW, Riet N, Abken H, Kashkar H, Hornig-Do HT, Wiesner RJ (2020). Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells. Carcinogenesis. 2020 Dec 31;41(12):1735-1745. doi: 10.1093/carcin/bgaa032
  • Urbanczyk, S., Baris, O., Mougiakakos, D., Wiesner, R., Jäck, H.M., and Mielenz, D. (2020). Essential respiratory chain subunits encoded by mitochondrial DNA control plasma cell development. J Immunol204.

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Andreas Wodarz

  • Witte L, Linnemannstoens K, Schmidt K, Honemann-Capito M, Grawe F, Wodarz A, Gross JC (2020). Kinesin motor Klp98A mediates apical to basal Wg transport. Development. 2020 Jul 14:dev.186833. doi: 10.1242/dev.186833 
  • Linnemannstöns K, Witte L, Karuna P, Kittel J, Danieli A, Müller D, Nitsch L, Honemann-Capito M, Grawe F, Wodarz A, Gross JC (2020). Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium. Development. 2020 Jul 1:dev.185421. doi: 10.1242/dev.185421
  • Hohmann C, Pfister R, Mollenhauer M, Adler C, Kozlowski J, Wodarz A, Drebber U, Wippermann J, Michels G (2020). Inflammatory cell infiltration in left atrial appendageal tissues of patients with atrial fibrillation and sinus rhythm. Sci Rep. 2020 Feb 3;10(1):1685. doi: 10.1038/s41598-020-58797-8

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Thomas Wunderlich

  • Mittenbühler MJ, Saedler K, Nolte H, Kern L, Zhou J, Qian SB, Meder L, Ullrich RT, Brüning JC, Wunderlich FT (2020). Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Mol Metab. 2020 Sep 18:101085. doi: 10.1016/j.molmet.2020.101085. Online ahead of print. PMID: 32956847  
  • Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. PMID: 32302532
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hoevelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling CD, Hartmann E, Rosenwald A, Klapper W, Buettner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt C, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT (2020). -Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood. 2020 Nov 2:blood.2020005734. doi: 10.1182/blood.2020005734. Online ahead of print. PMID: 33140819
  • Mehrjardi, N.Z., Molcanyi, M., Hatay, F.F., Timmer, M., Shahbazi, E., Ackermann, J.P., Herms, S., Heilmann-Heimbach, S., Wunderlich, T.F., Prochnow, N., Haghikia, A., Lampert, A., Hescheler, J., Neugebauer, E.A.M., Baharvand, H., and Saric, T. (2020). Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo. Cell Proliferat53. ARTN e12892. 10.1111/cpr.12892.
  • Schwardt, M., Köhn, D., Wunderlich, T., Wilken, D., Seeliger, M., Schmidts, T., Brückner, H., Basaran, S., and Rabbel, W. (2020). Characterization of silty to fine-sandy sediments with SH waves: full waveform inversion in comparison with other geophysical methods. Near Surf Geophys18, 217-248. 10.1002/nsg.12097.

 

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Branko Zevnik

  • Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Büning H, Yang L, Cao H, Jesus DF, Kulkarni RN, Zevnik B, Troder SE, Knippschild U, Edwards PA, Lee RG, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim TQA, Kornfeld JW (2020). A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism. Nat Commun. 11(1): 644. doi: 10.1038/s41467-020-14323-y

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